L3MBTL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. Members of this family function as methyl-lysine readers, which recognize methylated lysine residues on histone protein tails, and are associated with the repression of gene expression. The encoded protein may regulate hematopoiesis. Homozygous deletion of this gene has been observed in human patients with medulloblastoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.06183723
2DNA double-strand break processing (GO:0000729)5.12598119
3negative regulation of calcium ion-dependent exocytosis (GO:0045955)5.01429361
4negative regulation of leukocyte chemotaxis (GO:0002689)4.91187372
5central nervous system projection neuron axonogenesis (GO:0021952)4.83169989
6nucleobase catabolic process (GO:0046113)4.61184473
7cell fate commitment involved in formation of primary germ layer (GO:0060795)4.56582446
8regulation of telomere maintenance via telomerase (GO:0032210)4.56358914
9pre-miRNA processing (GO:0031054)4.38009950
10negative regulation of DNA-dependent DNA replication (GO:2000104)4.32470979
11response to nitrosative stress (GO:0051409)4.21209564
12establishment of nucleus localization (GO:0040023)4.21193084
13positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)4.15977050
14negative regulation of catenin import into nucleus (GO:0035414)4.07346193
15nuclear pore complex assembly (GO:0051292)4.06153669
16chromatin remodeling at centromere (GO:0031055)4.05277267
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.04596047
18negative regulation of cell killing (GO:0031342)4.04596047
19regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.97997921
20regulation of mitotic spindle checkpoint (GO:1903504)3.97997921
21regulation of macrophage chemotaxis (GO:0010758)3.94584408
22V(D)J recombination (GO:0033151)3.91583596
23CENP-A containing nucleosome assembly (GO:0034080)3.90591417
24limb bud formation (GO:0060174)3.90353449
25histone H2A acetylation (GO:0043968)3.85928313
26histone mRNA catabolic process (GO:0071044)3.82594511
27phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.79156489
28RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.71548017
29positive regulation of mRNA 3-end processing (GO:0031442)3.69756340
30monoubiquitinated protein deubiquitination (GO:0035520)3.66291802
31histone exchange (GO:0043486)3.65580993
32dendritic spine morphogenesis (GO:0060997)3.62971733
33pore complex assembly (GO:0046931)3.61210190
34replication fork processing (GO:0031297)3.61198729
35regulation of mRNA 3-end processing (GO:0031440)3.59802264
36clathrin coat assembly (GO:0048268)3.59203986
37regulation of translation, ncRNA-mediated (GO:0045974)3.57463408
38negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.57463408
39negative regulation of translation, ncRNA-mediated (GO:0040033)3.57463408
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.56866283
41mitotic G2/M transition checkpoint (GO:0044818)3.54894648
42central nervous system neuron axonogenesis (GO:0021955)3.50894073
43histone H2B ubiquitination (GO:0033523)3.50406906
44DNA ligation (GO:0006266)3.50129486
45histone mRNA metabolic process (GO:0008334)3.45254908
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.38372061
47positive regulation of mRNA processing (GO:0050685)3.31532031
48regulation of helicase activity (GO:0051095)3.31268369
49cerebellar Purkinje cell layer development (GO:0021680)3.31060408
50DNA replication-independent nucleosome assembly (GO:0006336)3.31028091
51DNA replication-independent nucleosome organization (GO:0034724)3.31028091
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30654264
53telomere maintenance via telomerase (GO:0007004)3.28027280
54regulation of meiosis I (GO:0060631)3.25802168
55cerebral cortex radially oriented cell migration (GO:0021799)3.24360379
56layer formation in cerebral cortex (GO:0021819)3.23012704
57response to X-ray (GO:0010165)3.22844839
58cell migration involved in heart development (GO:0060973)3.18550425
59artery development (GO:0060840)3.17834569
60regulation of centriole replication (GO:0046599)3.15826616
61response to xenobiotic stimulus (GO:0009410)3.12297234
62mitotic G2 DNA damage checkpoint (GO:0007095)3.11770360
63protein-DNA complex disassembly (GO:0032986)3.09466564
64nucleosome disassembly (GO:0006337)3.09466564
65ribonucleoprotein complex disassembly (GO:0032988)3.09045616
66regulation of telomere maintenance (GO:0032204)3.08763377
67estrogen biosynthetic process (GO:0006703)3.07299049
68ncRNA catabolic process (GO:0034661)3.03187706
69nucleus localization (GO:0051647)3.00646049
70DNA strand renaturation (GO:0000733)3.00253759
71interferon-gamma production (GO:0032609)2.99441513
72nuclear pore organization (GO:0006999)2.98649644
73spindle checkpoint (GO:0031577)2.98156457
74female gonad development (GO:0008585)2.98041436
75positive regulation of mRNA metabolic process (GO:1903313)2.96891658
76protein-cofactor linkage (GO:0018065)2.95817721
77negative regulation of fibroblast apoptotic process (GO:2000270)2.94085579
78mitotic spindle checkpoint (GO:0071174)2.91411159
79negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.91380171
80presynaptic membrane assembly (GO:0097105)2.85673582
81maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85646515
82negative regulation of NF-kappaB import into nucleus (GO:0042347)2.85204813
83negative regulation of DNA repair (GO:0045738)2.84906021
84regulation of DNA endoreduplication (GO:0032875)2.84840663
85organelle disassembly (GO:1903008)2.84117649
86regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.83949000
87negative regulation of DNA recombination (GO:0045910)2.82363238
88N-terminal protein amino acid acetylation (GO:0006474)2.82278350
89acrosome assembly (GO:0001675)2.80854371
90negative regulation of mitotic sister chromatid separation (GO:2000816)2.80224368
91negative regulation of sister chromatid segregation (GO:0033046)2.80224368
92negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.80224368
93negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.80224368
94negative regulation of mitotic sister chromatid segregation (GO:0033048)2.80224368
95RNA-dependent DNA replication (GO:0006278)2.78719859
96generation of neurons (GO:0048699)2.77730318
97negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.77038796
98regulation of mitotic metaphase/anaphase transition (GO:0030071)2.76285446
99regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.76285446
100centriole replication (GO:0007099)2.75731145
101head development (GO:0060322)2.75668519
102primitive streak formation (GO:0090009)2.73794545
103regulation of mesoderm development (GO:2000380)2.73508724
104DNA catabolic process, exonucleolytic (GO:0000738)2.71968587
105recombinational repair (GO:0000725)2.70618314
106dorsal/ventral axis specification (GO:0009950)2.69605307
107histamine secretion (GO:0001821)2.69509149
108germ cell migration (GO:0008354)2.67971380
109regulation of sister chromatid segregation (GO:0033045)2.66188035
110regulation of mitotic sister chromatid separation (GO:0010965)2.66188035
111regulation of mitotic sister chromatid segregation (GO:0033047)2.66188035
112replicative senescence (GO:0090399)2.65366644
113negative regulation of chromosome segregation (GO:0051985)2.63236911
114kinetochore assembly (GO:0051382)2.61454161
115regulation of non-canonical Wnt signaling pathway (GO:2000050)2.60375838
116negative regulation of mast cell activation (GO:0033004)2.59583845
117double-strand break repair via homologous recombination (GO:0000724)2.59077378
118anterior/posterior axis specification, embryo (GO:0008595)2.58559952
119DNA demethylation (GO:0080111)2.58008428
120transcription elongation from RNA polymerase I promoter (GO:0006362)2.55281524
121positive regulation of gamma-delta T cell activation (GO:0046645)2.55214568
122histone H3-K4 trimethylation (GO:0080182)2.54594293
123cytoplasmic mRNA processing body assembly (GO:0033962)2.54516373
124regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.53748227
125kinetochore organization (GO:0051383)2.52793990
126mitotic spindle assembly checkpoint (GO:0007094)2.52568392
127regulation of NFAT protein import into nucleus (GO:0051532)2.51192045
128regulation of protein heterodimerization activity (GO:0043497)2.47135647
129growth hormone secretion (GO:0030252)2.46658175
130alternative mRNA splicing, via spliceosome (GO:0000380)2.45719748
131dendrite morphogenesis (GO:0048813)2.43548321
132interkinetic nuclear migration (GO:0022027)2.41803544
133insulin-like growth factor receptor signaling pathway (GO:0048009)2.40766397
134positive regulation of CREB transcription factor activity (GO:0032793)2.38723056
135negative regulation of axon extension involved in axon guidance (GO:0048843)2.34847110
136G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.33564878
137negative regulation of axon guidance (GO:1902668)2.33206782
138cranial nerve morphogenesis (GO:0021602)2.32585790
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.31739293
140embryonic viscerocranium morphogenesis (GO:0048703)2.31438930
141regulation of B cell receptor signaling pathway (GO:0050855)2.30275583
142B cell homeostasis (GO:0001782)2.29167963
143energy homeostasis (GO:0097009)2.27964876
144facial nerve structural organization (GO:0021612)2.27554472
145axon extension involved in axon guidance (GO:0048846)2.26258907
146neuron projection extension involved in neuron projection guidance (GO:1902284)2.26258907
147positive regulation of axon extension (GO:0045773)2.25668895
148negative regulation of phagocytosis (GO:0050765)2.24047957
149B cell receptor signaling pathway (GO:0050853)2.22469704
150negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.21590818
151mRNA splice site selection (GO:0006376)2.21366760
152regulation of sister chromatid cohesion (GO:0007063)2.21150263
153B cell proliferation (GO:0042100)2.19762162
154DNA topological change (GO:0006265)2.19439850
155regulation of superoxide metabolic process (GO:0090322)2.19405873
156positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.19357955
157cardiovascular system development (GO:0072358)2.17909329
158definitive hemopoiesis (GO:0060216)2.16924398
159vocalization behavior (GO:0071625)2.16166322
160epithelial cell differentiation involved in kidney development (GO:0035850)2.15710855
161histamine transport (GO:0051608)2.14195553
162negative T cell selection (GO:0043383)2.13361953
163negative regulation of histone acetylation (GO:0035067)2.11885094
164histone H3-K36 demethylation (GO:0070544)2.10569306
165somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.08388380
166somatic cell DNA recombination (GO:0016444)2.08388380
167negative regulation of cell fate specification (GO:0009996)2.08068684
168positive regulation of erythrocyte differentiation (GO:0045648)2.03964897
169negative regulation of dendrite development (GO:2000171)2.03959442
170regulation of B cell differentiation (GO:0045577)2.01495543
171negative thymic T cell selection (GO:0045060)2.00931348
172DNA unwinding involved in DNA replication (GO:0006268)1.97897065
173axon extension (GO:0048675)1.97633881
174glucocorticoid receptor signaling pathway (GO:0042921)1.96897598
175protein localization to chromosome (GO:0034502)1.96751628
176non-recombinational repair (GO:0000726)1.95908324
177double-strand break repair via nonhomologous end joining (GO:0006303)1.95908324
178response to auditory stimulus (GO:0010996)1.94485965
179axonal fasciculation (GO:0007413)1.93561737
180base-excision repair (GO:0006284)1.93515227
181negative regulation of histone methylation (GO:0031061)1.92149477
182cell proliferation in forebrain (GO:0021846)1.92043865
183lymphocyte homeostasis (GO:0002260)1.91793756
184corticosteroid receptor signaling pathway (GO:0031958)1.91246918
185mitotic sister chromatid cohesion (GO:0007064)1.90554270
186platelet dense granule organization (GO:0060155)1.90270428
187positive regulation of synapse maturation (GO:0090129)1.89082750
188substrate-dependent cell migration (GO:0006929)1.89064572
189leukocyte aggregation (GO:0070486)1.88985671
190peptidyl-arginine N-methylation (GO:0035246)1.88471892
191peptidyl-arginine methylation (GO:0018216)1.88471892
192chondrocyte proliferation (GO:0035988)1.88032128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.38490398
2E2F7_22180533_ChIP-Seq_HELA_Human3.89803472
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.83946702
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.82612456
5EZH2_22144423_ChIP-Seq_EOC_Human3.38114115
6GBX2_23144817_ChIP-Seq_PC3_Human3.10616416
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.06335353
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.00151406
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.85163793
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.79768325
11MYC_22102868_ChIP-Seq_BL_Human2.58370463
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.56721424
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51787743
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51024105
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.45915816
16IGF1R_20145208_ChIP-Seq_DFB_Human2.44838519
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43801291
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.42557599
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.34097335
20* FUS_26573619_Chip-Seq_HEK293_Human2.31310418
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.25171992
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22648617
23POU5F1_16153702_ChIP-ChIP_HESCs_Human2.10937683
24RUNX_20019798_ChIP-Seq_JUKART_Human2.09486606
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.03719019
26ELK1_19687146_ChIP-ChIP_HELA_Human2.01871990
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97848940
28TAF15_26573619_Chip-Seq_HEK293_Human1.96631583
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.96031106
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.92599999
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89485290
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86734416
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85589483
34* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.83430837
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81999550
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76313253
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.71186493
38VDR_22108803_ChIP-Seq_LS180_Human1.70208824
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69982143
40SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67941292
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67477323
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66263080
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62985429
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62332007
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.59419366
46* EZH2_27294783_Chip-Seq_NPCs_Mouse1.58523890
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56846326
48RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.56808733
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56236393
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56028311
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.55708127
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54913687
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.53630608
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53453789
55* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.53027932
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51776074
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50912557
58ZNF274_21170338_ChIP-Seq_K562_Hela1.50851279
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.49931997
60AR_21572438_ChIP-Seq_LNCaP_Human1.49297320
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48911973
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48638522
63SMAD4_21799915_ChIP-Seq_A2780_Human1.47766003
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47056324
65* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46180065
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45322811
67TP53_18474530_ChIP-ChIP_U2OS_Human1.43990148
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43986062
69* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42733815
70* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42733815
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.42163628
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41942977
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.40116442
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38885578
75VDR_21846776_ChIP-Seq_THP-1_Human1.37118062
76IRF1_19129219_ChIP-ChIP_H3396_Human1.36993353
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36445005
78* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35766841
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35136395
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.34630033
81ER_23166858_ChIP-Seq_MCF-7_Human1.34352889
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33868555
83* EZH2_27304074_Chip-Seq_ESCs_Mouse1.33226468
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33042483
85MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32903739
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31253764
87* RNF2_27304074_Chip-Seq_ESCs_Mouse1.30562270
88VDR_24763502_ChIP-Seq_THP-1_Human1.29895135
89* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28735198
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26986390
91IRF8_21731497_ChIP-ChIP_J774_Mouse1.26538501
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26243993
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26057844
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.24913150
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24653238
96VDR_23849224_ChIP-Seq_CD4+_Human1.24217240
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24061726
98BCAT_22108803_ChIP-Seq_LS180_Human1.23619251
99TCF7_22412390_ChIP-Seq_EML_Mouse1.23170715
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22484185
101RNF2_27304074_Chip-Seq_NSC_Mouse1.21845382
102* RING1B_27294783_Chip-Seq_ESCs_Mouse1.21710644
103EWS_26573619_Chip-Seq_HEK293_Human1.21682869
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21066571
105SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19078831
106* MYB_26560356_Chip-Seq_TH2_Human1.18581537
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17912289
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17851943
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.17454148
110KDM2B_26808549_Chip-Seq_DND41_Human1.17434500
111IRF8_22096565_ChIP-ChIP_GC-B_Human1.17413515
112ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16431298
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16396935
114* FLI1_21867929_ChIP-Seq_TH2_Mouse1.15965063
115* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15841246
116CBP_20019798_ChIP-Seq_JUKART_Human1.15740076
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15740076
118ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15605525
119* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.15515230
120JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14560615
121* STAT3_23295773_ChIP-Seq_U87_Human1.14077550
122KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13407618
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13309568
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13169153
125NFE2_27457419_Chip-Seq_LIVER_Mouse1.12653446
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12089149
127BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11659633
128* TCF4_23295773_ChIP-Seq_U87_Human1.11323366
129FOXM1_23109430_ChIP-Seq_U2OS_Human1.10880240
130* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10713723
131NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10672294
132IRF8_27001747_Chip-Seq_BMDM_Mouse1.10429405
133CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10099646
134RUNX2_22187159_ChIP-Seq_PCA_Human1.09387187
135* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08899304
136* CRX_20693478_ChIP-Seq_RETINA_Mouse1.08603082
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08224147
138NANOG_18555785_Chip-Seq_ESCs_Mouse1.07127373
139P300_19829295_ChIP-Seq_ESCs_Human1.06436426
140MYC_18940864_ChIP-ChIP_HL60_Human1.06003585
141UTX_26944678_Chip-Seq_JUKART_Human1.05316145
142NANOG_16153702_ChIP-ChIP_HESCs_Human1.05281878
143* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04894634
144* RING1B_27294783_Chip-Seq_NPCs_Mouse1.04004573
145MAF_26560356_Chip-Seq_TH1_Human1.03347157
146TCF4_22108803_ChIP-Seq_LS180_Human1.03175282
147* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02638256
148* NANOG_19829295_ChIP-Seq_ESCs_Human1.02022209
149* SOX2_19829295_ChIP-Seq_ESCs_Human1.02022209
150* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01688566
151TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01526841
152POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01526841
153EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00992195
154FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00698406
155SCL_19346495_ChIP-Seq_HPC-7_Human1.00306379
156EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00168988
157TP53_16413492_ChIP-PET_HCT116_Human1.00024006
158* KDM2B_26808549_Chip-Seq_JURKAT_Human0.99853770
159DROSHA_22980978_ChIP-Seq_HELA_Human0.99240477
160* AR_25329375_ChIP-Seq_VCAP_Human0.98861415
161PRDM14_20953172_ChIP-Seq_ESCs_Human0.97918389
162* JUN_21703547_ChIP-Seq_K562_Human0.97451907
163CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96316247
164NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96065752
165FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95612619
166* EZH2_27294783_Chip-Seq_ESCs_Mouse0.94607521
167TP53_20018659_ChIP-ChIP_R1E_Mouse0.93739913
168* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.92769788
169IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91768089
170MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91150113
171* VDR_24787735_ChIP-Seq_THP-1_Human0.90439079
172SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90344098
173SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90344098
174YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89350843
175* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.85874285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.91186286
2MP0003890_abnormal_embryonic-extraembry4.13392289
3MP0006292_abnormal_olfactory_placode3.50397549
4MP0008057_abnormal_DNA_replication3.02315223
5MP0000383_abnormal_hair_follicle2.89156957
6MP0002396_abnormal_hematopoietic_system2.82036383
7MP0010030_abnormal_orbit_morphology2.69169135
8MP0008058_abnormal_DNA_repair2.68918890
9MP0005174_abnormal_tail_pigmentation2.65420738
10MP0004742_abnormal_vestibular_system2.63925798
11MP0004957_abnormal_blastocyst_morpholog2.53008907
12MP0008877_abnormal_DNA_methylation2.47318112
13MP0001293_anophthalmia2.23916009
14MP0003385_abnormal_body_wall2.20075237
15MP0000015_abnormal_ear_pigmentation2.20037366
16MP0003122_maternal_imprinting2.13815057
17MP0010678_abnormal_skin_adnexa2.13223453
18MP0000371_diluted_coat_color2.12510794
19MP0000427_abnormal_hair_cycle2.09468596
20MP0003119_abnormal_digestive_system2.05047259
21MP0003787_abnormal_imprinting2.03270055
22MP0003693_abnormal_embryo_hatching2.02136741
23MP0009278_abnormal_bone_marrow1.98877750
24MP0003121_genomic_imprinting1.95911221
25MP0005503_abnormal_tendon_morphology1.91755550
26MP0009697_abnormal_copulation1.87303978
27MP0004808_abnormal_hematopoietic_stem1.85353451
28MP0009053_abnormal_anal_canal1.70816488
29MP0001286_abnormal_eye_development1.62598600
30MP0003879_abnormal_hair_cell1.62094564
31MP0003303_peritoneal_inflammation1.58338232
32MP0008932_abnormal_embryonic_tissue1.57115869
33MP0001188_hyperpigmentation1.55167787
34MP0000778_abnormal_nervous_system1.55046041
35MP0001879_abnormal_lymphatic_vessel1.54724055
36MP0000647_abnormal_sebaceous_gland1.53520373
37MP0002751_abnormal_autonomic_nervous1.53330769
38MP0008789_abnormal_olfactory_epithelium1.53169285
39MP0005248_abnormal_Harderian_gland1.51787231
40MP0002938_white_spotting1.50490415
41MP0003937_abnormal_limbs/digits/tail_de1.50427131
42MP0002089_abnormal_postnatal_growth/wei1.48626042
43MP0000537_abnormal_urethra_morphology1.48604277
44MP0001835_abnormal_antigen_presentation1.46614124
45MP0002233_abnormal_nose_morphology1.42390245
46MP0002075_abnormal_coat/hair_pigmentati1.41247112
47MP0009250_abnormal_appendicular_skeleto1.36616548
48MP0002095_abnormal_skin_pigmentation1.36206221
49MP0003763_abnormal_thymus_physiology1.31333654
50MP0003111_abnormal_nucleus_morphology1.30572944
51MP0002102_abnormal_ear_morphology1.28430596
52MP0001545_abnormal_hematopoietic_system1.26976787
53MP0005397_hematopoietic_system_phenotyp1.26976787
54MP0004185_abnormal_adipocyte_glucose1.25258253
55MP0005623_abnormal_meninges_morphology1.24381145
56MP0004859_abnormal_synaptic_plasticity1.23759092
57MP0006054_spinal_hemorrhage1.23649531
58MP0005499_abnormal_olfactory_system1.21682908
59MP0005394_taste/olfaction_phenotype1.21682908
60MP0002452_abnormal_antigen_presenting1.20081032
61MP0003011_delayed_dark_adaptation1.18161480
62MP0003123_paternal_imprinting1.18080149
63MP0002084_abnormal_developmental_patter1.17562551
64MP0002282_abnormal_trachea_morphology1.16581180
65MP0002398_abnormal_bone_marrow1.15324939
66MP0001485_abnormal_pinna_reflex1.14102919
67MP0003943_abnormal_hepatobiliary_system1.13812713
68MP0005671_abnormal_response_to1.12509803
69MP0001800_abnormal_humoral_immune1.11028064
70MP0000703_abnormal_thymus_morphology1.10462320
71MP0001177_atelectasis1.09214796
72MP0002420_abnormal_adaptive_immunity1.09033132
73MP0001819_abnormal_immune_cell1.08966136
74MP0003221_abnormal_cardiomyocyte_apopto1.08205400
75MP0003315_abnormal_perineum_morphology1.07176571
76MP0008007_abnormal_cellular_replicative1.06899157
77MP0003279_aneurysm1.06362132
78MP0003436_decreased_susceptibility_to1.06007245
79MP0003941_abnormal_skin_development1.05366359
80MP0005075_abnormal_melanosome_morpholog1.03684710
81MP0003718_maternal_effect1.03592268
82MP0003786_premature_aging1.03537421
83MP0000613_abnormal_salivary_gland1.03173328
84MP0002932_abnormal_joint_morphology1.01794914
85MP0002085_abnormal_embryonic_tissue1.01748616
86MP0001958_emphysema1.01357948
87MP0001186_pigmentation_phenotype1.00332175
88MP0009703_decreased_birth_body1.00289666
89MP0000685_abnormal_immune_system0.99964297
90MP0003091_abnormal_cell_migration0.99861657
91MP0001727_abnormal_embryo_implantation0.99713358
92MP0002254_reproductive_system_inflammat0.99639145
93MP0005551_abnormal_eye_electrophysiolog0.98468238
94MP0001790_abnormal_immune_system0.98296210
95MP0005387_immune_system_phenotype0.98296210
96MP0000733_abnormal_muscle_development0.98157163
97MP0010094_abnormal_chromosome_stability0.97874745
98MP0001672_abnormal_embryogenesis/_devel0.97307441
99MP0005380_embryogenesis_phenotype0.97307441
100MP0004197_abnormal_fetal_growth/weight/0.96261817
101MP0001697_abnormal_embryo_size0.95384881
102MP0001730_embryonic_growth_arrest0.95250251
103MP0006072_abnormal_retinal_apoptosis0.94660094
104MP0009785_altered_susceptibility_to0.93546178
105MP0010368_abnormal_lymphatic_system0.92588463
106MP0002419_abnormal_innate_immunity0.92535497
107MP0000631_abnormal_neuroendocrine_gland0.92126802
108MP0003935_abnormal_craniofacial_develop0.91439095
109MP0010352_gastrointestinal_tract_polyps0.90813386
110MP0002723_abnormal_immune_serum0.90579302
111MP0006035_abnormal_mitochondrial_morpho0.90054799
112MP0002234_abnormal_pharynx_morphology0.88954074
113MP0000716_abnormal_immune_system0.88723862
114MP0000350_abnormal_cell_proliferation0.88704130
115MP0002113_abnormal_skeleton_development0.87067411
116MP0002210_abnormal_sex_determination0.86958214
117MP0002116_abnormal_craniofacial_bone0.86609915
118MP0003755_abnormal_palate_morphology0.86120019
119MP0005000_abnormal_immune_tolerance0.86016585
120MP0002184_abnormal_innervation0.85673269
121MP0005197_abnormal_uvea_morphology0.84699779
122MP0000516_abnormal_urinary_system0.83912505
123MP0005367_renal/urinary_system_phenotyp0.83912505
124MP0002249_abnormal_larynx_morphology0.83873919
125MP0002092_abnormal_eye_morphology0.83828992
126MP0000465_gastrointestinal_hemorrhage0.83823109
127MP0002088_abnormal_embryonic_growth/wei0.83785909
128MP0002697_abnormal_eye_size0.83213537
129MP0005310_abnormal_salivary_gland0.82816783
130MP0003984_embryonic_growth_retardation0.82128614
131MP0000462_abnormal_digestive_system0.81920502
132MP0002086_abnormal_extraembryonic_tissu0.81222519
133MP0002006_tumorigenesis0.81211816
134MP0002925_abnormal_cardiovascular_devel0.80957582
135MP0005391_vision/eye_phenotype0.80771431
136MP0003861_abnormal_nervous_system0.80167641
137MP0000372_irregular_coat_pigmentation0.79579895
138MP0005076_abnormal_cell_differentiation0.79141286
139MP0001915_intracranial_hemorrhage0.78798266
140MP0000653_abnormal_sex_gland0.78716539
141MP0008995_early_reproductive_senescence0.78693258
142MP0002098_abnormal_vibrissa_morphology0.78356976
143MP0002177_abnormal_outer_ear0.78216151
144MP0002722_abnormal_immune_system0.78159936
145MP0000767_abnormal_smooth_muscle0.77893081
146MP0003705_abnormal_hypodermis_morpholog0.77454652
147MP0002405_respiratory_system_inflammati0.76672230
148MP0000858_altered_metastatic_potential0.76497727
149MP0002998_abnormal_bone_remodeling0.76277741
150MP0002109_abnormal_limb_morphology0.75246655
151MP0001119_abnormal_female_reproductive0.73482512
152MP0000432_abnormal_head_morphology0.72471977
153MP0001145_abnormal_male_reproductive0.72290944
154MP0001324_abnormal_eye_pigmentation0.72268292
155MP0003077_abnormal_cell_cycle0.72210454
156MP0000049_abnormal_middle_ear0.71779246
157* MP0002429_abnormal_blood_cell0.71708288
158MP0002736_abnormal_nociception_after0.71048550
159MP0005508_abnormal_skeleton_morphology0.70999610
160MP0005025_abnormal_response_to0.70806896
161MP0003567_abnormal_fetal_cardiomyocyte0.69686832
162MP0009384_cardiac_valve_regurgitation0.69224090
163MP0000428_abnormal_craniofacial_morphol0.69188184
164MP0005187_abnormal_penis_morphology0.68164157

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)4.98500242
2Focal motor seizures (HP:0011153)4.59416048
3Absence seizures (HP:0002121)4.02019854
4Abnormality of the labia minora (HP:0012880)3.76930212
5Abnormality of the parathyroid morphology (HP:0011766)3.73476039
6Short 4th metacarpal (HP:0010044)3.71552853
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.71552853
8Nephroblastoma (Wilms tumor) (HP:0002667)3.70240985
9Embryonal renal neoplasm (HP:0011794)3.48913063
10Abnormal lung lobation (HP:0002101)3.39686887
11Trigonocephaly (HP:0000243)3.33641916
12Hepatoblastoma (HP:0002884)3.31345097
13Abnormal hair whorl (HP:0010721)3.27030106
14Spinal cord lesions (HP:0100561)3.23161972
15Syringomyelia (HP:0003396)3.23161972
16Volvulus (HP:0002580)3.06629691
17Autoamputation (HP:0001218)2.96199840
18Focal seizures (HP:0007359)2.93123202
19Abnormality of chromosome stability (HP:0003220)2.92417021
20Amblyopia (HP:0000646)2.85665642
21Hypochromic microcytic anemia (HP:0004840)2.83466492
22Heterochromia iridis (HP:0001100)2.81278948
23Dialeptic seizures (HP:0011146)2.80100133
24Ectopic kidney (HP:0000086)2.80060464
25Abnormality of the 4th metacarpal (HP:0010012)2.68303271
26Gonadotropin excess (HP:0000837)2.64507648
27Poor speech (HP:0002465)2.61688189
28Increased density of long bones (HP:0006392)2.51467993
29Disinhibition (HP:0000734)2.45576193
30Degeneration of anterior horn cells (HP:0002398)2.45481119
31Abnormality of the anterior horn cell (HP:0006802)2.45481119
32Progressive inability to walk (HP:0002505)2.44938049
33Stenosis of the external auditory canal (HP:0000402)2.43396525
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.42623764
35Broad-based gait (HP:0002136)2.41679565
36Methylmalonic acidemia (HP:0002912)2.38648955
37Aplasia of the musculature (HP:0100854)2.38389312
38Papilledema (HP:0001085)2.37718472
39Palpebral edema (HP:0100540)2.37168198
40Neoplasm of the adrenal cortex (HP:0100641)2.34427327
41Small hand (HP:0200055)2.34001070
42Asymmetry of the thorax (HP:0001555)2.31974562
43Amyotrophic lateral sclerosis (HP:0007354)2.31159281
44Hyperventilation (HP:0002883)2.30034139
45Subacute progressive viral hepatitis (HP:0006572)2.28225602
46Cupped ear (HP:0000378)2.24748817
47Genital tract atresia (HP:0001827)2.24516074
48Partial agenesis of the corpus callosum (HP:0001338)2.23635815
49Inappropriate behavior (HP:0000719)2.21071686
50Albinism (HP:0001022)2.20829640
51Urethral obstruction (HP:0000796)2.19709382
52Meckel diverticulum (HP:0002245)2.17739717
53Duodenal stenosis (HP:0100867)2.16205345
54Small intestinal stenosis (HP:0012848)2.16205345
55Bifid tongue (HP:0010297)2.15479347
56Shallow orbits (HP:0000586)2.15281622
57Optic nerve hypoplasia (HP:0000609)2.15280070
58Vaginal atresia (HP:0000148)2.14745496
59Increased hepatocellular lipid droplets (HP:0006565)2.14611287
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14111479
61Neoplasm of the oral cavity (HP:0100649)2.12683926
62Atrophy/Degeneration involving motor neurons (HP:0007373)2.12263107
63Bilateral microphthalmos (HP:0007633)2.12194106
64Absent frontal sinuses (HP:0002688)2.11853350
65Abnormality of the ileum (HP:0001549)2.10791956
66Large eyes (HP:0001090)2.10608879
67Abnormality of the preputium (HP:0100587)2.10114214
68Renal hypoplasia (HP:0000089)2.06608424
69Absent speech (HP:0001344)2.06362695
70Papillary thyroid carcinoma (HP:0002895)2.06256719
71Long clavicles (HP:0000890)2.05893811
72Septo-optic dysplasia (HP:0100842)2.03715704
73Mesomelia (HP:0003027)2.03565259
74Abnormality of the duodenum (HP:0002246)2.03549575
75Abnormality of the intervertebral disk (HP:0005108)2.01304382
76Triphalangeal thumb (HP:0001199)2.00833005
77Clubbing of toes (HP:0100760)2.00806920
78Abnormality of the nasal septum (HP:0000419)2.00238836
79Medial flaring of the eyebrow (HP:0010747)1.99969567
80Rhabdomyosarcoma (HP:0002859)1.98087577
81Uterine leiomyosarcoma (HP:0002891)1.95202114
82Leiomyosarcoma (HP:0100243)1.95202114
83Periorbital edema (HP:0100539)1.94327529
84Sloping forehead (HP:0000340)1.94202791
85Growth hormone deficiency (HP:0000824)1.93344649
86Colon cancer (HP:0003003)1.92485554
87Transitional cell carcinoma of the bladder (HP:0006740)1.92166199
88Congenital primary aphakia (HP:0007707)1.91490169
89Patellar dislocation (HP:0002999)1.91018921
90Stomach cancer (HP:0012126)1.90537128
91Lymphangioma (HP:0100764)1.89560645
92Advanced eruption of teeth (HP:0006288)1.89308314
93Inability to walk (HP:0002540)1.88353821
94Scrotal hypoplasia (HP:0000046)1.87887008
95Stomatitis (HP:0010280)1.87605363
96Mediastinal lymphadenopathy (HP:0100721)1.86981986
97Pancreatic fibrosis (HP:0100732)1.86874699
98Eosinophilia (HP:0001880)1.85004986
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84704411
100Osteolytic defects of the phalanges of the hand (HP:0009771)1.83873633
101Osteolytic defects of the hand bones (HP:0009699)1.83873633
102Adrenal hypoplasia (HP:0000835)1.83262108
103Facial hemangioma (HP:0000329)1.82591528
104Embryonal neoplasm (HP:0002898)1.81893086
105Abnormality of methionine metabolism (HP:0010901)1.81631330
106Chromsome breakage (HP:0040012)1.80360563
107Myelodysplasia (HP:0002863)1.79959129
108Facial edema (HP:0000282)1.79425148
109Cellulitis (HP:0100658)1.79033940
110Abnormality of homocysteine metabolism (HP:0010919)1.77936143
111Homocystinuria (HP:0002156)1.77936143
112Biliary tract neoplasm (HP:0100574)1.77289345
113Capillary hemangiomas (HP:0005306)1.76827093
114Gait imbalance (HP:0002141)1.76013460
115Renal duplication (HP:0000075)1.74570419
116Neoplasm of the adrenal gland (HP:0100631)1.73772272
117Preaxial foot polydactyly (HP:0001841)1.73311571
118Abnormality of the metopic suture (HP:0005556)1.73225095
119Granulocytopenia (HP:0001913)1.73020998
120Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72536911
121Abnormality of the astrocytes (HP:0100707)1.72434689
122Astrocytoma (HP:0009592)1.72434689
123Recurrent abscess formation (HP:0002722)1.72365321
124Mild short stature (HP:0003502)1.72320496
125Pancreatic islet-cell hyperplasia (HP:0004510)1.71060421
126Abnormality of midbrain morphology (HP:0002418)1.70471561
127Molar tooth sign on MRI (HP:0002419)1.70471561
128Pancreatic cysts (HP:0001737)1.70153302
129Dyschromatopsia (HP:0007641)1.69565068
130Abnormality of DNA repair (HP:0003254)1.69081496
131Acute myeloid leukemia (HP:0004808)1.68846849
132True hermaphroditism (HP:0010459)1.68519445
133Glioma (HP:0009733)1.67960660
134Drooling (HP:0002307)1.67811508
135Acute lymphatic leukemia (HP:0006721)1.67355231
136Eczematoid dermatitis (HP:0000976)1.67038679
137Poor head control (HP:0002421)1.66932186
138Lipid accumulation in hepatocytes (HP:0006561)1.66800527
139Abnormality of the pons (HP:0007361)1.66784398
140Preaxial hand polydactyly (HP:0001177)1.66471221
141Decreased testicular size (HP:0008734)1.66241185
142Intestinal atresia (HP:0011100)1.65385910
143Recurrent bacterial skin infections (HP:0005406)1.65283551
144Poor coordination (HP:0002370)1.65038878
145Thyroid carcinoma (HP:0002890)1.64661999
146Nephrogenic diabetes insipidus (HP:0009806)1.64160118
147Spinal muscular atrophy (HP:0007269)1.63596778
148Limited elbow extension (HP:0001377)1.63515164
149Exertional dyspnea (HP:0002875)1.63213462
150Respiratory difficulties (HP:0002880)1.62970334
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.62698230
152Micropenis (HP:0000054)1.62582043
153Hip dysplasia (HP:0001385)1.62227195
154Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.61611703
155Deviation of the thumb (HP:0009603)1.61354190
156Proximal placement of thumb (HP:0009623)1.61216886
157Bladder neoplasm (HP:0009725)1.60707581
158Bladder carcinoma (HP:0002862)1.60707581
159Long eyelashes (HP:0000527)1.60146497
160Aplasia/Hypoplasia of the sternum (HP:0006714)1.59750013
161Mutism (HP:0002300)1.58828523
162Viral hepatitis (HP:0006562)1.58435107
163Hematochezia (HP:0002573)1.58032036
164Concave nail (HP:0001598)1.57825738
165Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.57503450
166Bilateral sensorineural hearing impairment (HP:0008619)1.57485949
167Germ cell neoplasia (HP:0100728)1.57279208
168Obstructive lung disease (HP:0006536)1.56063561
169Chronic obstructive pulmonary disease (HP:0006510)1.56063561
170Pelvic girdle muscle weakness (HP:0003749)1.55920997
171Protruding tongue (HP:0010808)1.54401635
172Abnormal number of incisors (HP:0011064)1.53573346
173Exostoses (HP:0100777)1.52364586
174Increased serum pyruvate (HP:0003542)1.52298954
175Abnormality of glycolysis (HP:0004366)1.52298954
176Broad thumb (HP:0011304)1.50892561
177Arterial tortuosity (HP:0005116)1.50491681
178Abnormality of the radial head (HP:0003995)1.49814781
179Elfin facies (HP:0004428)1.49536016
180Aqueductal stenosis (HP:0002410)1.49466105
181Overgrowth (HP:0001548)1.49349372
182Hyperacusis (HP:0010780)1.48930085
183Abnormality of the fingertips (HP:0001211)1.48635691
184Neoplasm of the heart (HP:0100544)1.47428864
185Lissencephaly (HP:0001339)1.46729682
186Hypoplasia of the maxilla (HP:0000327)1.46340879
187Morphological abnormality of the middle ear (HP:0008609)1.45933285
188Patellar aplasia (HP:0006443)1.45732083
189Broad ribs (HP:0000885)1.44950207
190Meningitis (HP:0001287)1.44752112
191Malignant gastrointestinal tract tumors (HP:0006749)1.44715550
192Gastrointestinal carcinoma (HP:0002672)1.44715550
193Thick eyebrow (HP:0000574)1.44323139
194Vascular tortuosity (HP:0004948)1.43339513

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK26.54404528
2MARK14.67387659
3WEE14.63115524
4MAP3K123.97141403
5SIK33.96893132
6PBK2.96215511
7RIPK12.83500663
8ERBB32.83279440
9BRSK12.63927309
10BMPR1B2.61093690
11PNCK2.58703524
12FGFR22.48395122
13CASK2.38191356
14FGFR32.30874314
15NTRK22.17424759
16TAF12.12598097
17SIK22.09309683
18WNK32.02774888
19MST42.00320736
20FGFR41.92288495
21PLK41.92233373
22PDGFRA1.92023326
23MAP3K101.87684291
24TXK1.84542637
25LATS21.78744440
26TRIM281.74918410
27SRPK11.73759583
28KSR11.68260277
29MINK11.66213388
30ZAK1.61844170
31DYRK21.61232144
32MKNK21.55933102
33EPHB21.54911543
34TSSK61.47503885
35PLK31.45094596
36VRK21.44156833
37MAPK131.43413892
38TIE11.36141772
39MAP4K11.35003881
40EEF2K1.34337338
41PKN21.34014029
42MKNK11.32986712
43BUB11.27365252
44ACVR1B1.25110438
45YES11.22122033
46TAOK11.21805180
47FRK1.21294145
48EIF2AK31.19107382
49BRD41.17446880
50CDK81.15940987
51MAP2K71.15016700
52VRK11.11943842
53NEK91.11348017
54MAP4K21.09570618
55MAP3K51.05064061
56RIPK41.04339357
57CLK11.03200097
58ITK0.99221115
59TYRO30.98463830
60TTK0.98131212
61MAPK40.97850485
62MAP3K140.96780167
63EIF2AK20.94115834
64EPHB10.91424733
65MAP3K110.90425454
66ALK0.87793917
67DDR20.87387083
68RPS6KA20.87057202
69PLK10.86846128
70FGFR10.85095869
71STK38L0.84819391
72SYK0.81445450
73CSNK1A1L0.81409668
74NUAK10.81393096
75CAMK1G0.79809090
76MARK20.78890062
77CDK180.77278996
78CHUK0.75385664
79MAP2K40.75245957
80PDGFRB0.74534392
81SGK20.74056348
82NLK0.73920977
83MELK0.73638538
84CSNK1G10.72853130
85CDK40.71996553
86STK30.71946406
87PLK20.71779504
88CDK30.70929283
89KIT0.69834516
90MAP3K90.68822044
91MAP3K60.67731882
92NEK10.66264873
93RPS6KA40.66253826
94FGR0.65060824
95TGFBR20.64862282
96JAK30.64836066
97DYRK30.64029206
98MAP3K70.62729993
99GRK10.62386112
100EPHA30.62124275
101PRKG20.61687335
102BTK0.60617924
103CDK150.60511394
104STK240.59681011
105TGFBR10.59555493
106MAP3K40.59440577
107PINK10.58605595
108LATS10.57851321
109STK100.56627705
110PAK30.56016645
111CDK11A0.55866604
112TEC0.55452744
113STK390.55390361
114AKT20.55288578
115MAPK120.54428047
116JAK10.54055986
117MAPK70.53941173
118CSF1R0.53455688
119FER0.53281591
120EIF2AK10.53247154
121TAOK20.52759602
122CDK140.52305804
123CSNK1G20.50598092
124OXSR10.50458029
125CDK60.50220727
126ADRBK20.49779012
127PIM20.49139485
128PASK0.47990579
129PRKCI0.47645690
130DYRK1B0.47645014
131ATR0.47042417
132LYN0.46495973
133DYRK1A0.45557267
134HCK0.45512891
135PRKCH0.45407579
136AKT30.44756514
137ERBB40.44513727
138MAPK90.43147482
139ATM0.42634119
140RET0.41196133
141INSRR0.39511087
142BLK0.38988590
143BCR0.38818363
144CDK50.38805760
145CDC70.38749433
146PTK60.38583304
147TYK20.38427521
148NEK20.38260274
149CDK90.37772340
150TRPM70.37568474
151MAPK100.36617640
152TNIK0.36311070
153FLT30.30905714
154NME10.29921177
155CSNK1G30.29872607
156STK40.25943289
157EGFR0.25602393
158STK110.24700249
159CSNK1D0.24095026
160FES0.23552199
161SMG10.22252804
162IRAK20.22213161
163IRAK10.20587487
164TAOK30.19567021
165CHEK20.18618082
166CSNK1E0.17397381
167PRKCE0.17338012

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.84477793
2Regulation of autophagy_Homo sapiens_hsa041402.98549577
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.91402380
4Basal transcription factors_Homo sapiens_hsa030222.86746146
5Protein export_Homo sapiens_hsa030602.75945448
6Homologous recombination_Homo sapiens_hsa034402.67618978
7Mismatch repair_Homo sapiens_hsa034302.32945011
8RNA polymerase_Homo sapiens_hsa030202.27010842
9Propanoate metabolism_Homo sapiens_hsa006402.22885872
10Fanconi anemia pathway_Homo sapiens_hsa034602.08939539
11Proteasome_Homo sapiens_hsa030502.07416330
12Colorectal cancer_Homo sapiens_hsa052102.00593995
13Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.99042341
14Viral myocarditis_Homo sapiens_hsa054161.95321988
15Steroid biosynthesis_Homo sapiens_hsa001001.93060846
16Nucleotide excision repair_Homo sapiens_hsa034201.80012921
17Base excision repair_Homo sapiens_hsa034101.78624435
18Leishmaniasis_Homo sapiens_hsa051401.73676746
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72819146
20B cell receptor signaling pathway_Homo sapiens_hsa046621.64332977
21Axon guidance_Homo sapiens_hsa043601.60666344
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54253738
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.50582295
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48873342
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.47697654
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42949398
27Primary immunodeficiency_Homo sapiens_hsa053401.42151996
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36511368
29p53 signaling pathway_Homo sapiens_hsa041151.34639344
30Hedgehog signaling pathway_Homo sapiens_hsa043401.32717954
31Small cell lung cancer_Homo sapiens_hsa052221.32488555
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31406383
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31299384
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.29027037
35Hepatitis B_Homo sapiens_hsa051611.29014913
36Chronic myeloid leukemia_Homo sapiens_hsa052201.27504574
37Pancreatic cancer_Homo sapiens_hsa052121.27497524
38T cell receptor signaling pathway_Homo sapiens_hsa046601.23666024
39Osteoclast differentiation_Homo sapiens_hsa043801.23200504
40Selenocompound metabolism_Homo sapiens_hsa004501.22916484
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.22596860
42Endometrial cancer_Homo sapiens_hsa052131.20564832
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18911585
44HTLV-I infection_Homo sapiens_hsa051661.18103785
45TNF signaling pathway_Homo sapiens_hsa046681.17477145
46Toxoplasmosis_Homo sapiens_hsa051451.17114151
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16766141
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14944964
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12859059
50Phototransduction_Homo sapiens_hsa047441.11280622
51Chemokine signaling pathway_Homo sapiens_hsa040621.11077387
52Olfactory transduction_Homo sapiens_hsa047401.09376836
53MicroRNAs in cancer_Homo sapiens_hsa052061.09159907
54Adherens junction_Homo sapiens_hsa045201.09150405
55Acute myeloid leukemia_Homo sapiens_hsa052211.08708212
56Shigellosis_Homo sapiens_hsa051311.07714211
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06567408
58Measles_Homo sapiens_hsa051621.05464874
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04634228
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02959037
61Spliceosome_Homo sapiens_hsa030401.02611973
62Basal cell carcinoma_Homo sapiens_hsa052171.02387493
63Glioma_Homo sapiens_hsa052140.99985069
64Salmonella infection_Homo sapiens_hsa051320.97943601
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97349019
66Non-small cell lung cancer_Homo sapiens_hsa052230.96301999
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96231391
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95963169
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90768519
70Hippo signaling pathway_Homo sapiens_hsa043900.90719305
71Pathways in cancer_Homo sapiens_hsa052000.89642550
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.89448395
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89044181
74Apoptosis_Homo sapiens_hsa042100.89020788
75Herpes simplex infection_Homo sapiens_hsa051680.88881506
76MAPK signaling pathway_Homo sapiens_hsa040100.88252334
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87686119
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.87669675
79Wnt signaling pathway_Homo sapiens_hsa043100.87045735
80Proteoglycans in cancer_Homo sapiens_hsa052050.85236076
81Focal adhesion_Homo sapiens_hsa045100.84952753
82Purine metabolism_Homo sapiens_hsa002300.83578457
83TGF-beta signaling pathway_Homo sapiens_hsa043500.83566314
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83529817
85Cell cycle_Homo sapiens_hsa041100.83453957
86Epstein-Barr virus infection_Homo sapiens_hsa051690.83292785
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83077153
88Platelet activation_Homo sapiens_hsa046110.83010131
89Notch signaling pathway_Homo sapiens_hsa043300.82208044
90Tuberculosis_Homo sapiens_hsa051520.82186175
91DNA replication_Homo sapiens_hsa030300.81803582
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.81063875
93Influenza A_Homo sapiens_hsa051640.80917936
94Oocyte meiosis_Homo sapiens_hsa041140.80678368
95ErbB signaling pathway_Homo sapiens_hsa040120.80247249
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80111369
97Pertussis_Homo sapiens_hsa051330.79872995
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.79111753
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77719905
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77296688
101Cocaine addiction_Homo sapiens_hsa050300.74192987
102Rap1 signaling pathway_Homo sapiens_hsa040150.72042176
103Inositol phosphate metabolism_Homo sapiens_hsa005620.71633523
104Hematopoietic cell lineage_Homo sapiens_hsa046400.71598303
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70266740
106mRNA surveillance pathway_Homo sapiens_hsa030150.69804315
107Viral carcinogenesis_Homo sapiens_hsa052030.69698932
108Morphine addiction_Homo sapiens_hsa050320.68664788
109VEGF signaling pathway_Homo sapiens_hsa043700.68663944
110Prostate cancer_Homo sapiens_hsa052150.68228418
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68226075
112Hepatitis C_Homo sapiens_hsa051600.67597597
113Pyrimidine metabolism_Homo sapiens_hsa002400.66277364
114Prolactin signaling pathway_Homo sapiens_hsa049170.64717219
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.63590127
116Dorso-ventral axis formation_Homo sapiens_hsa043200.63240210
117Graft-versus-host disease_Homo sapiens_hsa053320.62802913
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62623737
119Cholinergic synapse_Homo sapiens_hsa047250.62608711
120Gap junction_Homo sapiens_hsa045400.61451261
121Estrogen signaling pathway_Homo sapiens_hsa049150.61414553
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61354749
123mTOR signaling pathway_Homo sapiens_hsa041500.61256694
124Asthma_Homo sapiens_hsa053100.60992486
125RNA degradation_Homo sapiens_hsa030180.60669937
126African trypanosomiasis_Homo sapiens_hsa051430.60637307
127Amoebiasis_Homo sapiens_hsa051460.60381386
128GnRH signaling pathway_Homo sapiens_hsa049120.60162914
129FoxO signaling pathway_Homo sapiens_hsa040680.59126933
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59096351
131Dopaminergic synapse_Homo sapiens_hsa047280.58877158
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.58876153
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58022945
134RNA transport_Homo sapiens_hsa030130.57561572
135Thyroid cancer_Homo sapiens_hsa052160.53884095
136Lysine degradation_Homo sapiens_hsa003100.49702700
137Butanoate metabolism_Homo sapiens_hsa006500.46889821
138Vitamin digestion and absorption_Homo sapiens_hsa049770.45681264
139ABC transporters_Homo sapiens_hsa020100.44190960
140Glycerolipid metabolism_Homo sapiens_hsa005610.40431082
141Taste transduction_Homo sapiens_hsa047420.40084641
142Fatty acid degradation_Homo sapiens_hsa000710.39961001
143Ether lipid metabolism_Homo sapiens_hsa005650.37950959
144Ras signaling pathway_Homo sapiens_hsa040140.36175551
145One carbon pool by folate_Homo sapiens_hsa006700.36132367
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36106531
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32277835
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31667499
149Caffeine metabolism_Homo sapiens_hsa002320.30502990
150PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30367666
151beta-Alanine metabolism_Homo sapiens_hsa004100.29286455
152Steroid hormone biosynthesis_Homo sapiens_hsa001400.28953972
153Legionellosis_Homo sapiens_hsa051340.27429105
154Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24537224
155Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24366369
156Glutathione metabolism_Homo sapiens_hsa004800.22176120
157Serotonergic synapse_Homo sapiens_hsa047260.20698916
158Chemical carcinogenesis_Homo sapiens_hsa052040.19427724

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