LACE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)6.95553728
2carnitine shuttle (GO:0006853)6.02608342
3lysine catabolic process (GO:0006554)5.83660953
4lysine metabolic process (GO:0006553)5.83660953
5NADH metabolic process (GO:0006734)5.77051878
6fatty acid transmembrane transport (GO:1902001)5.66753594
7regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.60951362
8fatty acid beta-oxidation (GO:0006635)5.47193879
92-oxoglutarate metabolic process (GO:0006103)5.37606742
10regulation of acyl-CoA biosynthetic process (GO:0050812)5.13139623
11tricarboxylic acid metabolic process (GO:0072350)4.91643434
12regulation of sequestering of triglyceride (GO:0010889)4.88972736
13regulation of cofactor metabolic process (GO:0051193)4.82741909
14regulation of coenzyme metabolic process (GO:0051196)4.82741909
15aspartate family amino acid catabolic process (GO:0009068)4.81819018
16fatty acid oxidation (GO:0019395)4.72737970
17fatty acid catabolic process (GO:0009062)4.72083938
18branched-chain amino acid catabolic process (GO:0009083)4.71677145
19lipid oxidation (GO:0034440)4.66302764
20RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.62777221
21tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.62777221
22carnitine transport (GO:0015879)4.60326895
23amino-acid betaine transport (GO:0015838)4.60326895
24carnitine transmembrane transport (GO:1902603)4.60106013
25biotin metabolic process (GO:0006768)4.58632162
26cellular ketone body metabolic process (GO:0046950)4.57894797
27succinate metabolic process (GO:0006105)4.55326212
28acetyl-CoA metabolic process (GO:0006084)4.54737174
29short-chain fatty acid metabolic process (GO:0046459)4.50732492
30oxaloacetate metabolic process (GO:0006107)4.45787808
31branched-chain amino acid metabolic process (GO:0009081)4.44123302
32behavioral response to nicotine (GO:0035095)4.43436813
33regulation of fatty acid oxidation (GO:0046320)4.35111283
34valine metabolic process (GO:0006573)4.29008149
35sarcomere organization (GO:0045214)4.21555238
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.13735049
37carnitine metabolic process (GO:0009437)4.11044279
38monocarboxylic acid catabolic process (GO:0072329)4.09752539
39adenosine metabolic process (GO:0046085)4.09016404
40centriole replication (GO:0007099)3.96833953
41fucose catabolic process (GO:0019317)3.95973867
42L-fucose metabolic process (GO:0042354)3.95973867
43L-fucose catabolic process (GO:0042355)3.95973867
44ketone body metabolic process (GO:1902224)3.93004498
45amino-acid betaine metabolic process (GO:0006577)3.91328487
46quaternary ammonium group transport (GO:0015697)3.87632574
47L-phenylalanine metabolic process (GO:0006558)3.87468352
48erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.87468352
49regulation of sulfur metabolic process (GO:0042762)3.85507286
50protein-cofactor linkage (GO:0018065)3.84793127
51fatty acid homeostasis (GO:0055089)3.84501748
52positive regulation of fatty acid oxidation (GO:0046321)3.83937683
53glyoxylate metabolic process (GO:0046487)3.79745217
54erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.77303953
55L-phenylalanine catabolic process (GO:0006559)3.77303953
56cardiac myofibril assembly (GO:0055003)3.76785286
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73019114
58negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.70063364
59bundle of His cell to Purkinje myocyte communication (GO:0086069)3.67983399
60mitochondrial respiratory chain complex I assembly (GO:0032981)3.62607214
61NADH dehydrogenase complex assembly (GO:0010257)3.62607214
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.62607214
63protein complex biogenesis (GO:0070271)3.61797529
64response to pheromone (GO:0019236)3.61632326
65positive regulation of fatty acid beta-oxidation (GO:0032000)3.59726874
66respiratory electron transport chain (GO:0022904)3.56196452
67alpha-linolenic acid metabolic process (GO:0036109)3.55778359
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.53629319
69oxidative phosphorylation (GO:0006119)3.52684815
70regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.52623888
71epithelial cilium movement (GO:0003351)3.51356519
72rRNA methylation (GO:0031167)3.50286707
73tryptophan catabolic process (GO:0006569)3.48887028
74indole-containing compound catabolic process (GO:0042436)3.48887028
75indolalkylamine catabolic process (GO:0046218)3.48887028
76cardiac muscle contraction (GO:0060048)3.48679781
77negative regulation of fatty acid biosynthetic process (GO:0045717)3.48074646
78negative regulation of fatty acid metabolic process (GO:0045922)3.47746461
79electron transport chain (GO:0022900)3.46191778
80positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.42058820
81negative regulation of potassium ion transmembrane transport (GO:1901380)3.40391112
82regulation of triglyceride catabolic process (GO:0010896)3.40171045
83primary amino compound metabolic process (GO:1901160)3.39324466
84detection of light stimulus involved in visual perception (GO:0050908)3.38958371
85detection of light stimulus involved in sensory perception (GO:0050962)3.38958371
86mitochondrial respiratory chain complex assembly (GO:0033108)3.33597116
87regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.31624435
88mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.28347000
89energy coupled proton transport, down electrochemical gradient (GO:0015985)3.27473590
90ATP synthesis coupled proton transport (GO:0015986)3.27473590
91indolalkylamine metabolic process (GO:0006586)3.27138996
92intracellular lipid transport (GO:0032365)3.26918704
93organic acid catabolic process (GO:0016054)3.26806347
94carboxylic acid catabolic process (GO:0046395)3.26806347
95homocysteine metabolic process (GO:0050667)3.25347255
96cilium or flagellum-dependent cell motility (GO:0001539)3.24999828
97phospholipid homeostasis (GO:0055091)3.24615646
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.22930907
99ventricular cardiac muscle cell action potential (GO:0086005)3.22481443
100behavioral response to ethanol (GO:0048149)3.22236854
101acyl-CoA biosynthetic process (GO:0071616)3.21709200
102thioester biosynthetic process (GO:0035384)3.21709200
103respiratory chain complex IV assembly (GO:0008535)3.19990030
104triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.19722494
105preassembly of GPI anchor in ER membrane (GO:0016254)3.19679133
106gluconeogenesis (GO:0006094)3.17740714
107sulfur amino acid catabolic process (GO:0000098)3.17592023
108cell communication involved in cardiac conduction (GO:0086065)3.17591356
109kynurenine metabolic process (GO:0070189)3.17363283
110myofibril assembly (GO:0030239)3.16872089
111detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15126315
112cysteine metabolic process (GO:0006534)3.11342863
113tryptophan metabolic process (GO:0006568)3.09806665
114axoneme assembly (GO:0035082)3.08980684
115rRNA modification (GO:0000154)3.08109020
116cardiac muscle cell development (GO:0055013)3.07411120
117regulation of fatty acid metabolic process (GO:0019217)3.07192278
118platelet dense granule organization (GO:0060155)3.06370289
119regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.03981026
120acyl-CoA metabolic process (GO:0006637)3.03314523
121thioester metabolic process (GO:0035383)3.03314523
122ethanol oxidation (GO:0006069)3.02603019
123regulation of fatty acid beta-oxidation (GO:0031998)3.01955675
124regulation of cilium movement (GO:0003352)3.01829145
125cellular modified amino acid catabolic process (GO:0042219)2.99574254
126cellular amino acid catabolic process (GO:0009063)2.99400977
127mitochondrial RNA metabolic process (GO:0000959)2.97660219
128folic acid-containing compound biosynthetic process (GO:0009396)2.96910008
129aromatic amino acid family catabolic process (GO:0009074)2.96762257
130microtubule nucleation (GO:0007020)2.95093205
131C-terminal protein lipidation (GO:0006501)2.94487102
132adult feeding behavior (GO:0008343)2.94311359
133hexose biosynthetic process (GO:0019319)2.93241847
134alpha-amino acid catabolic process (GO:1901606)2.93182680
135mannosylation (GO:0097502)2.92542804
136regulation of hexokinase activity (GO:1903299)2.92180720
137regulation of glucokinase activity (GO:0033131)2.92180720
138reciprocal DNA recombination (GO:0035825)2.91662540
139reciprocal meiotic recombination (GO:0007131)2.91662540
140dicarboxylic acid biosynthetic process (GO:0043650)2.91137928
141C-terminal protein amino acid modification (GO:0018410)2.90115722
142protein K11-linked deubiquitination (GO:0035871)2.87704779
143coenzyme catabolic process (GO:0009109)2.87374444
144cilium movement (GO:0003341)2.85812964
145phosphate ion transmembrane transport (GO:0035435)2.85329823
146cytochrome complex assembly (GO:0017004)2.84202131
147retinal cone cell development (GO:0046549)2.83216636
148response to mercury ion (GO:0046689)2.82968559
149adaptation of signaling pathway (GO:0023058)2.82188740
150inner mitochondrial membrane organization (GO:0007007)2.81218385
151regulation of cholesterol metabolic process (GO:0090181)2.80980651
152nonmotile primary cilium assembly (GO:0035058)2.80960020
153establishment of protein localization to Golgi (GO:0072600)2.80514360
154cilium organization (GO:0044782)2.79536456
155G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79427404
156tRNA processing (GO:0008033)2.78978406
157tachykinin receptor signaling pathway (GO:0007217)2.78415437
158cardiac cell development (GO:0055006)2.78353188
159cellular biogenic amine catabolic process (GO:0042402)2.74924126
160amine catabolic process (GO:0009310)2.74924126
161cilium assembly (GO:0042384)2.74770756
162single strand break repair (GO:0000012)2.74511252
163GPI anchor metabolic process (GO:0006505)2.73896794
164indole-containing compound metabolic process (GO:0042430)2.72758270
165L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.71894671
166signal peptide processing (GO:0006465)2.68881528
167photoreceptor cell maintenance (GO:0045494)2.68762155
168cilium morphogenesis (GO:0060271)2.65596066
169negative regulation of cytosolic calcium ion concentration (GO:0051481)2.65193656
170auditory receptor cell stereocilium organization (GO:0060088)2.63500304
171replication fork processing (GO:0031297)2.61805326
172axonemal dynein complex assembly (GO:0070286)2.57970667
173S-adenosylmethionine metabolic process (GO:0046500)2.56847649
174DNA deamination (GO:0045006)2.56235428
175photoreceptor cell development (GO:0042461)2.53735725
176centriole assembly (GO:0098534)2.53689867
177pseudouridine synthesis (GO:0001522)2.52871292
178multicellular organism reproduction (GO:0032504)2.52621424
179inner ear receptor stereocilium organization (GO:0060122)2.52471284
180gamma-aminobutyric acid transport (GO:0015812)2.51644822
181recombinational repair (GO:0000725)2.49828134
182dopamine transport (GO:0015872)2.48489285
183double-strand break repair via homologous recombination (GO:0000724)2.48051837
184neural tube formation (GO:0001841)2.47603645
185tRNA modification (GO:0006400)2.46696914
186reflex (GO:0060004)2.46311746
187positive regulation of mitochondrial fission (GO:0090141)2.44190109
188organic cation transport (GO:0015695)2.43400999
189piRNA metabolic process (GO:0034587)2.42103426
190estrogen biosynthetic process (GO:0006703)2.41994796
191protein targeting to Golgi (GO:0000042)2.41414966
192alanine transport (GO:0032328)2.41209515
193drug catabolic process (GO:0042737)2.39906202
194pteridine-containing compound biosynthetic process (GO:0042559)2.39602916
195positive regulation of histone H3-K4 methylation (GO:0051571)2.39539424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.58266760
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.19284631
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.16788797
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse5.01154443
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.92672880
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.10300685
7LXR_22158963_ChIP-Seq_LIVER_Mouse4.06647843
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.73993163
9ZNF274_21170338_ChIP-Seq_K562_Hela3.36249673
10GBX2_23144817_ChIP-Seq_PC3_Human3.28186683
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.12551086
12CLOCK_20551151_ChIP-Seq_293T_Human2.88257627
13VDR_22108803_ChIP-Seq_LS180_Human2.87686114
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67106023
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.66475862
16* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60642754
17EZH2_22144423_ChIP-Seq_EOC_Human2.56901649
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55835090
19ZNF263_19887448_ChIP-Seq_K562_Human2.54997469
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54697102
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.53790075
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.51653143
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.48492063
24FUS_26573619_Chip-Seq_HEK293_Human2.40707078
25IGF1R_20145208_ChIP-Seq_DFB_Human2.36872714
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.21410300
27EWS_26573619_Chip-Seq_HEK293_Human2.20004884
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18040644
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.17428253
30TAF15_26573619_Chip-Seq_HEK293_Human2.15263177
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.12669560
32RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12274733
33* P300_19829295_ChIP-Seq_ESCs_Human2.11452952
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09745740
35CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09267843
36EP300_21415370_ChIP-Seq_HL-1_Mouse2.07913733
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06885428
38TBX20_22328084_ChIP-Seq_HEART_Mouse2.03574431
39TBX20_22080862_ChIP-Seq_HEART_Mouse2.03574431
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.96222225
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91492627
42PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.83707492
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.82852484
44ER_23166858_ChIP-Seq_MCF-7_Human1.82339854
45GATA1_22025678_ChIP-Seq_K562_Human1.77505251
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76432352
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.75240922
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73348568
49TP53_22573176_ChIP-Seq_HFKS_Human1.70497800
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.69332883
51CBP_20019798_ChIP-Seq_JUKART_Human1.69332883
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68859867
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66252116
54* STAT3_23295773_ChIP-Seq_U87_Human1.64788523
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58951792
56TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.57513308
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55344683
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53559661
59* SMAD4_21799915_ChIP-Seq_A2780_Human1.53321691
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51514672
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51201790
62* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51131220
63KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50487857
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45905676
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45437707
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.45016296
67* TCF4_23295773_ChIP-Seq_U87_Human1.43632190
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.40467064
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39474921
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38614468
71* EST1_17652178_ChIP-ChIP_JURKAT_Human1.38598042
72* EZH2_27294783_Chip-Seq_NPCs_Mouse1.38428338
73FOXA2_19822575_ChIP-Seq_HepG2_Human1.38230246
74AR_25329375_ChIP-Seq_VCAP_Human1.37845919
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35380787
76TCF4_22108803_ChIP-Seq_LS180_Human1.34367903
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34106185
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34017045
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.32828976
80* NANOG_19829295_ChIP-Seq_ESCs_Human1.31914074
81* SOX2_19829295_ChIP-Seq_ESCs_Human1.31914074
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.31473641
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30313456
84ELK1_19687146_ChIP-ChIP_HELA_Human1.26025840
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.25822086
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25601038
87CDX2_22108803_ChIP-Seq_LS180_Human1.24507981
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.23991250
89RUNX2_22187159_ChIP-Seq_PCA_Human1.23703020
90ESR1_20079471_ChIP-ChIP_T-47D_Human1.23630004
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23615350
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22481321
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.21186180
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21078166
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.18251117
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.17474714
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17474714
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17230738
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17189763
100MYC_18940864_ChIP-ChIP_HL60_Human1.15217411
101* CRX_20693478_ChIP-Seq_RETINA_Mouse1.14559358
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14349222
103NCOR_22424771_ChIP-Seq_293T_Human1.14073560
104* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13296988
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13121232
106REST_21632747_ChIP-Seq_MESCs_Mouse1.12769581
107PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12457861
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.11691973
109* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10853017
110VDR_23849224_ChIP-Seq_CD4+_Human1.10563945
111SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09797712
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09225050
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09225050
114CBX2_27304074_Chip-Seq_ESCs_Mouse1.08759033
115* FLI1_21867929_ChIP-Seq_TH2_Mouse1.08586185
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08499669
117HOXB7_26014856_ChIP-Seq_BT474_Human1.07480089
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07181046
119GATA4_21415370_ChIP-Seq_HL-1_Mouse1.07174090
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06620966
121TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06493912
122* HNF4A_19822575_ChIP-Seq_HepG2_Human1.06357104
123P53_22387025_ChIP-Seq_ESCs_Mouse1.04952923
124GATA3_21878914_ChIP-Seq_MCF-7_Human1.03283440
125AR_20517297_ChIP-Seq_VCAP_Human1.02775014
126IRF1_19129219_ChIP-ChIP_H3396_Human1.02642225
127ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02446045
128E2F1_18555785_Chip-Seq_ESCs_Mouse1.01549354
129RNF2_27304074_Chip-Seq_NSC_Mouse1.00833599
130AR_21572438_ChIP-Seq_LNCaP_Human1.00099812
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98631670
132MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98341250
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.98123781
134RACK7_27058665_Chip-Seq_MCF-7_Human0.97196249
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97080559
136POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96083812
137PHF8_20622853_ChIP-Seq_HELA_Human0.95631641
138ATF3_27146783_Chip-Seq_COLON_Human0.95496733
139* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94650175
140* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94445156
141CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93067140
142FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91835909
143TRIM28_21343339_ChIP-Seq_HEK293_Human0.91163874
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90375007
145GATA2_21666600_ChIP-Seq_HMVEC_Human0.89887455
146PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89853962
147LXR_22292898_ChIP-Seq_THP-1_Human0.89340430
148GATA4_25053715_ChIP-Seq_YYC3_Human0.88023872
149BCAT_22108803_ChIP-Seq_LS180_Human0.87988697
150NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85084393
151GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.84095841
152CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80836309
153ESR1_21235772_ChIP-Seq_MCF-7_Human0.80572850
154HIF1A_21447827_ChIP-Seq_MCF-7_Human0.78610794
155STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78446829
156POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78274930
157PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.77643659
158TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77385042
159GATA2_19941826_ChIP-Seq_K562_Human0.77222614
160TP63_22573176_ChIP-Seq_HFKS_Human0.76965186
161CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.76420594
162BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76187778
163AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76004713
164NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.75642691
165P68_20966046_ChIP-Seq_HELA_Human0.75580112
166AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74939609
167* RUNX1_27514584_Chip-Seq_MCF-7_Human0.74329398
168CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.74246735
169NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.74097851
170KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.73957655
171ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72425930
172GATA1_19941826_ChIP-Seq_K562_Human0.70370571
173SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69976660
174SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.69553665
175NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.69001711
176SOX9_24532713_ChIP-Seq_HFSC_Mouse0.67634245
177PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.67357766
178GATA6_25053715_ChIP-Seq_YYC3_Human0.67266805
179BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66697037
180SRF_21415370_ChIP-Seq_HL-1_Mouse0.66654187
181ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.65749391
182FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.65191598
183SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.63474272
184ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62937160
185SOX2_20726797_ChIP-Seq_SW620_Human0.62196553
186* FOXH1_21741376_ChIP-Seq_ESCs_Human0.62015496
187TET1_21451524_ChIP-Seq_MESCs_Mouse0.60980221
188GATA3_24758297_ChIP-Seq_MCF-7_Human0.60265088
189* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58067967
190SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.57608869
191RXRA_24833708_ChIP-Seq_LIVER_Mouse0.57253060
192OCT4_18692474_ChIP-Seq_MEFs_Mouse0.57092932
193EGR1_19032775_ChIP-ChIP_M12_Human0.57056647
194BCOR_27268052_Chip-Seq_Bcells_Human0.56586993
195CTCF_21964334_Chip-Seq_Bcells_Human0.56167415
196SMC4_20622854_ChIP-Seq_HELA_Human0.56023524

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.02756186
2MP0003646_muscle_fatigue4.38533140
3MP0004084_abnormal_cardiac_muscle3.82739860
4MP0002139_abnormal_hepatobiliary_system3.79044178
5MP0005360_urolithiasis3.68576671
6MP0004130_abnormal_muscle_cell3.24822771
7MP0005646_abnormal_pituitary_gland3.24482549
8MP0004215_abnormal_myocardial_fiber3.20483692
9MP0005365_abnormal_bile_salt3.11530840
10MP0005085_abnormal_gallbladder_physiolo3.05501163
11MP0005670_abnormal_white_adipose2.99527226
12MP0000751_myopathy2.90701051
13MP0004036_abnormal_muscle_relaxation2.90139670
14MP0005330_cardiomyopathy2.67693797
15MP0002736_abnormal_nociception_after2.62896534
16MP0003806_abnormal_nucleotide_metabolis2.62324066
17MP0008877_abnormal_DNA_methylation2.60321100
18MP0005551_abnormal_eye_electrophysiolog2.46075156
19MP0005666_abnormal_adipose_tissue2.43009409
20MP0009840_abnormal_foam_cell2.39293233
21MP0005645_abnormal_hypothalamus_physiol2.37055815
22MP0008875_abnormal_xenobiotic_pharmacok2.35395826
23MP0006036_abnormal_mitochondrial_physio2.29859958
24MP0005332_abnormal_amino_acid2.23350329
25MP0001968_abnormal_touch/_nociception2.19385198
26MP0008775_abnormal_heart_ventricle2.17143611
27MP0000749_muscle_degeneration2.13115688
28MP0002972_abnormal_cardiac_muscle2.10716043
29MP0005253_abnormal_eye_physiology2.02938057
30MP0003191_abnormal_cellular_cholesterol1.99898127
31MP0004087_abnormal_muscle_fiber1.98806605
32MP0009046_muscle_twitch1.97276749
33MP0008995_early_reproductive_senescence1.92237968
34MP0008872_abnormal_physiological_respon1.91773972
35MP0001544_abnormal_cardiovascular_syste1.90247206
36MP0005385_cardiovascular_system_phenoty1.90247206
37MP0000372_irregular_coat_pigmentation1.89554752
38MP0010329_abnormal_lipoprotein_level1.87952281
39MP0004484_altered_response_of1.87621723
40MP0003787_abnormal_imprinting1.87241760
41MP0004885_abnormal_endolymph1.85738048
42MP0003136_yellow_coat_color1.78434973
43MP0006138_congestive_heart_failure1.77340634
44MP0005620_abnormal_muscle_contractility1.77048834
45MP0006072_abnormal_retinal_apoptosis1.76962989
46MP0002938_white_spotting1.76023863
47MP0000631_abnormal_neuroendocrine_gland1.74089652
48MP0003137_abnormal_impulse_conducting1.71927078
49MP0002118_abnormal_lipid_homeostasis1.71551135
50MP0002234_abnormal_pharynx_morphology1.71510940
51MP0006276_abnormal_autonomic_nervous1.68302345
52MP0002269_muscular_atrophy1.67376396
53MP0002102_abnormal_ear_morphology1.67031860
54MP0002272_abnormal_nervous_system1.66447411
55MP0004185_abnormal_adipocyte_glucose1.65910157
56MP0010630_abnormal_cardiac_muscle1.65263942
57MP0004142_abnormal_muscle_tone1.65123945
58MP0002971_abnormal_brown_adipose1.63912254
59MP0000569_abnormal_digit_pigmentation1.61415202
60MP0008058_abnormal_DNA_repair1.60710603
61MP0009745_abnormal_behavioral_response1.58642144
62MP0001666_abnormal_nutrient_absorption1.55773230
63MP0002822_catalepsy1.55723007
64MP0003221_abnormal_cardiomyocyte_apopto1.55649256
65MP0001486_abnormal_startle_reflex1.51791245
66MP0005375_adipose_tissue_phenotype1.50518591
67MP0003252_abnormal_bile_duct1.48934720
68MP0002735_abnormal_chemical_nociception1.48759145
69MP0004043_abnormal_pH_regulation1.48506571
70MP0005083_abnormal_biliary_tract1.42856096
71MP0009643_abnormal_urine_homeostasis1.42222107
72MP0003718_maternal_effect1.41971775
73MP0004133_heterotaxia1.41464762
74MP0003195_calcinosis1.40889557
75MP0006035_abnormal_mitochondrial_morpho1.39848530
76MP0005379_endocrine/exocrine_gland_phen1.39144507
77MP0005410_abnormal_fertilization1.38097382
78MP0002106_abnormal_muscle_physiology1.38086464
79MP0002876_abnormal_thyroid_physiology1.36978408
80MP0005584_abnormal_enzyme/coenzyme_acti1.34891146
81MP0002332_abnormal_exercise_endurance1.34549116
82MP0003011_delayed_dark_adaptation1.33686463
83MP0000609_abnormal_liver_physiology1.33044797
84MP0005319_abnormal_enzyme/_coenzyme1.32287685
85MP0000750_abnormal_muscle_regeneration1.30739813
86MP0001984_abnormal_olfaction1.30735404
87MP0004085_abnormal_heartbeat1.26309794
88MP0008961_abnormal_basal_metabolism1.24550230
89MP0005084_abnormal_gallbladder_morpholo1.23396862
90MP0001485_abnormal_pinna_reflex1.22996728
91MP0002638_abnormal_pupillary_reflex1.22986561
92MP0005535_abnormal_body_temperature1.22765368
93MP0005451_abnormal_body_composition1.19337961
94MP0002078_abnormal_glucose_homeostasis1.19049480
95MP0003283_abnormal_digestive_organ1.17931107
96MP0003828_pulmonary_edema1.16303078
97MP0000013_abnormal_adipose_tissue1.15958615
98MP0003880_abnormal_central_pattern1.15662028
99MP0000747_muscle_weakness1.15609489
100MP0003698_abnormal_male_reproductive1.13338319
101MP0005266_abnormal_metabolism1.12380865
102MP0002572_abnormal_emotion/affect_behav1.09628291
103MP0004233_abnormal_muscle_weight1.09408495
104MP0001661_extended_life_span1.08522221
105MP0001970_abnormal_pain_threshold1.08377084
106MP0001929_abnormal_gametogenesis1.06320626
107MP0003890_abnormal_embryonic-extraembry1.06131880
108MP0000230_abnormal_systemic_arterial1.05906422
109MP0002229_neurodegeneration1.05608046
110MP0002184_abnormal_innervation1.05077989
111MP0002095_abnormal_skin_pigmentation1.04991405
112MP0002733_abnormal_thermal_nociception1.04670582
113MP0001905_abnormal_dopamine_level1.04071926
114MP0001529_abnormal_vocalization1.03937373
115MP0004019_abnormal_vitamin_homeostasis1.03874378
116MP0005377_hearing/vestibular/ear_phenot1.02929266
117MP0003878_abnormal_ear_physiology1.02929266
118MP0005167_abnormal_blood-brain_barrier1.02520494
119MP0002909_abnormal_adrenal_gland1.01479511
120MP0000759_abnormal_skeletal_muscle1.01470347
121MP0004742_abnormal_vestibular_system1.00692711
122MP0002067_abnormal_sensory_capabilities0.98780422
123MP0005369_muscle_phenotype0.98375223
124MP0000647_abnormal_sebaceous_gland0.98300073
125MP0001501_abnormal_sleep_pattern0.98013497
126MP0006292_abnormal_olfactory_placode0.97954197
127MP0000343_altered_response_to0.97653124
128MP0003705_abnormal_hypodermis_morpholog0.97492473
129MP0002557_abnormal_social/conspecific_i0.96741381
130MP0000427_abnormal_hair_cycle0.95394463
131MP0010386_abnormal_urinary_bladder0.94187020
132MP0002210_abnormal_sex_determination0.93888148
133MP0000003_abnormal_adipose_tissue0.93789393
134MP0001756_abnormal_urination0.93445413
135MP0002064_seizures0.93025807
136MP0003786_premature_aging0.92577620
137MP0003300_gastrointestinal_ulcer0.92261097
138MP0005334_abnormal_fat_pad0.92126840
139MP0004924_abnormal_behavior0.90316971
140MP0005386_behavior/neurological_phenoty0.90316971
141MP0000653_abnormal_sex_gland0.89456635
142MP0002163_abnormal_gland_morphology0.89381944
143MP0002653_abnormal_ependyma_morphology0.89321838
144MP0005075_abnormal_melanosome_morpholog0.89181988
145MP0003121_genomic_imprinting0.89039670
146MP0005187_abnormal_penis_morphology0.88974559
147MP0000383_abnormal_hair_follicle0.88731470
148MP0001919_abnormal_reproductive_system0.88164816
149MP0005389_reproductive_system_phenotype0.87513310
150MP0002160_abnormal_reproductive_system0.87145227
151MP0000026_abnormal_inner_ear0.86911419
152MP0004510_myositis0.84916442
153MP0009115_abnormal_fat_cell0.84721340
154MP0004147_increased_porphyrin_level0.84534085
155MP0008789_abnormal_olfactory_epithelium0.84163193
156MP0001986_abnormal_taste_sensitivity0.84009406
157MP0003186_abnormal_redox_activity0.83403010
158MP0001963_abnormal_hearing_physiology0.83019632
159MP0005165_increased_susceptibility_to0.81778319
160MP0002127_abnormal_cardiovascular_syste0.80914365
161MP0002138_abnormal_hepatobiliary_system0.80176511
162MP0003329_amyloid_beta_deposits0.76128546
163MP0002970_abnormal_white_adipose0.75481925
164MP0004145_abnormal_muscle_electrophysio0.74893372
165MP0005448_abnormal_energy_balance0.72853594
166MP0002877_abnormal_melanocyte_morpholog0.71881796
167MP0003567_abnormal_fetal_cardiomyocyte0.71244079
168MP0001764_abnormal_homeostasis0.69247461
169MP0003868_abnormal_feces_composition0.68698318
170MP0005376_homeostasis/metabolism_phenot0.68400949
171MP0010234_abnormal_vibrissa_follicle0.68228736
172MP0001765_abnormal_ion_homeostasis0.67286700
173MP0005636_abnormal_mineral_homeostasis0.65333131
174MP0010368_abnormal_lymphatic_system0.61484802
175MP0005058_abnormal_lysosome_morphology0.61120150
176MP0003953_abnormal_hormone_level0.58557493
177MP0000266_abnormal_heart_morphology0.58435335
178MP0000598_abnormal_liver_morphology0.57793574
179MP0009642_abnormal_blood_homeostasis0.56203415

Predicted human phenotypes

RankGene SetZ-score
1Myoglobinuria (HP:0002913)4.84013032
2Hypoglycemic coma (HP:0001325)4.71084010
3Hyperglycinuria (HP:0003108)4.62753378
4Sudden death (HP:0001699)4.44331242
5Ketoacidosis (HP:0001993)4.42371414
6Abnormality of fatty-acid metabolism (HP:0004359)4.31128320
7Pancreatic cysts (HP:0001737)4.24302227
8Ketosis (HP:0001946)4.23801135
9Exercise-induced myalgia (HP:0003738)4.19974420
10Ventricular tachycardia (HP:0004756)4.14650574
11Rhabdomyolysis (HP:0003201)4.10686425
12Dicarboxylic aciduria (HP:0003215)4.02434828
13Abnormality of dicarboxylic acid metabolism (HP:0010995)4.02434828
14Chronic hepatic failure (HP:0100626)3.97166168
15Abnormality of glycine metabolism (HP:0010895)3.93733339
16Abnormality of serine family amino acid metabolism (HP:0010894)3.93733339
17Hepatic necrosis (HP:0002605)3.91112477
18Hyperammonemia (HP:0001987)3.90673472
19Generalized aminoaciduria (HP:0002909)3.77039688
20Exercise-induced muscle cramps (HP:0003710)3.76580776
21Abnormality of midbrain morphology (HP:0002418)3.76424315
22Molar tooth sign on MRI (HP:0002419)3.76424315
23Pancreatic fibrosis (HP:0100732)3.76218637
24Right ventricular cardiomyopathy (HP:0011663)3.73706587
25Palpitations (HP:0001962)3.59328664
26Attenuation of retinal blood vessels (HP:0007843)3.56814302
27Cerebral edema (HP:0002181)3.43154522
28Nephronophthisis (HP:0000090)3.39592890
29Increased muscle lipid content (HP:0009058)3.33741519
30True hermaphroditism (HP:0010459)3.32982727
31Gout (HP:0001997)3.27659509
32Acute encephalopathy (HP:0006846)3.16532318
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.13430911
34Constricted visual fields (HP:0001133)3.12858441
35Hepatocellular necrosis (HP:0001404)3.12394984
36Hyperglycinemia (HP:0002154)3.11415150
37Atrial fibrillation (HP:0005110)3.10624602
38Abnormal mitochondria in muscle tissue (HP:0008316)3.05044526
39Lipoatrophy (HP:0100578)3.04615417
40Abnormality of the renal cortex (HP:0011035)3.04331486
41Medial flaring of the eyebrow (HP:0010747)3.03637546
42Calf muscle hypertrophy (HP:0008981)2.99347823
43Congenital sensorineural hearing impairment (HP:0008527)2.98656177
44Congenital stationary night blindness (HP:0007642)2.98588001
45Bile duct proliferation (HP:0001408)2.96974458
46Abnormal biliary tract physiology (HP:0012439)2.96974458
47Proximal tubulopathy (HP:0000114)2.96470872
48Metabolic acidosis (HP:0001942)2.94505613
49Abnormality of the renal medulla (HP:0100957)2.92626547
50Muscle fiber splitting (HP:0003555)2.91170110
51Primary atrial arrhythmia (HP:0001692)2.89028079
52Hyporeflexia of lower limbs (HP:0002600)2.88187117
53Lethargy (HP:0001254)2.87040962
54Bundle branch block (HP:0011710)2.84156985
55Dilated cardiomyopathy (HP:0001644)2.82745161
56Syncope (HP:0001279)2.81837791
57Acute necrotizing encephalopathy (HP:0006965)2.79314818
58Lactic acidosis (HP:0003128)2.78094762
59Supraventricular tachycardia (HP:0004755)2.77396359
60Abolished electroretinogram (ERG) (HP:0000550)2.77065162
61Xanthomatosis (HP:0000991)2.76692278
62Supraventricular arrhythmia (HP:0005115)2.71968393
63Asymmetric septal hypertrophy (HP:0001670)2.69028612
64Hyperinsulinemic hypoglycemia (HP:0000825)2.67722976
65Type II lissencephaly (HP:0007260)2.67179737
66Hypoalphalipoproteinemia (HP:0003233)2.66970778
67Abnormal rod and cone electroretinograms (HP:0008323)2.66903971
68Muscle hypertrophy of the lower extremities (HP:0008968)2.64578612
69Increased intramyocellular lipid droplets (HP:0012240)2.63697890
70Increased CSF lactate (HP:0002490)2.62993855
71Abnormality of glycolysis (HP:0004366)2.61439644
72Increased serum pyruvate (HP:0003542)2.61439644
73Renal cortical cysts (HP:0000803)2.54940786
74Decreased electroretinogram (ERG) amplitude (HP:0000654)2.54866807
75Ventricular arrhythmia (HP:0004308)2.53614624
76Hyperuricemia (HP:0002149)2.53087985
77Increased purine levels (HP:0004368)2.53087985
78Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51370056
79Intrahepatic cholestasis (HP:0001406)2.50257391
80Mitochondrial inheritance (HP:0001427)2.49724220
81Conjunctival hamartoma (HP:0100780)2.49168495
82Ragged-red muscle fibers (HP:0003200)2.48931601
83Nausea (HP:0002018)2.47149411
84Abnormality of urine glucose concentration (HP:0011016)2.47016108
85Glycosuria (HP:0003076)2.47016108
86Atrioventricular block (HP:0001678)2.46216000
87Abnormality of purine metabolism (HP:0004352)2.45342876
88Heart block (HP:0012722)2.45079158
89Vomiting (HP:0002013)2.44911789
90Tubular atrophy (HP:0000092)2.43990628
91Abnormality of aromatic amino acid family metabolism (HP:0004338)2.43736314
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43057199
93Abnormality of alanine metabolism (HP:0010916)2.43057199
94Hyperalaninemia (HP:0003348)2.43057199
953-Methylglutaconic aciduria (HP:0003535)2.41148663
96Abnormality of the calf musculature (HP:0001430)2.38928039
97Progressive macrocephaly (HP:0004481)2.37206559
98Cystic liver disease (HP:0006706)2.36248499
99Pheochromocytoma (HP:0002666)2.31859605
100Abnormality of serum amino acid levels (HP:0003112)2.31363549
101Late onset (HP:0003584)2.30832023
102Muscle stiffness (HP:0003552)2.29920994
103Difficulty running (HP:0009046)2.29393191
104Pendular nystagmus (HP:0012043)2.28763412
105Gaze-evoked nystagmus (HP:0000640)2.28502052
106Increased connective tissue (HP:0009025)2.28341444
107Abnormal atrioventricular conduction (HP:0005150)2.27636118
108Type 2 muscle fiber atrophy (HP:0003554)2.22093673
109Hypolipoproteinemia (HP:0010981)2.22071077
110Respiratory failure (HP:0002878)2.20362865
111Gait imbalance (HP:0002141)2.16711678
112Inability to walk (HP:0002540)2.16552855
113Lipid accumulation in hepatocytes (HP:0006561)2.16501745
114Congenital primary aphakia (HP:0007707)2.16134018
115Aplasia/Hypoplasia of the tibia (HP:0005772)2.14408594
116Abnormal respiratory epithelium morphology (HP:0012253)2.14338582
117Abnormal respiratory motile cilium morphology (HP:0005938)2.14338582
118Hyperglycemia (HP:0003074)2.12665629
119Absent/shortened dynein arms (HP:0200106)2.12492815
120Dynein arm defect of respiratory motile cilia (HP:0012255)2.12492815
121Hydroxyprolinuria (HP:0003080)2.12111549
122Abnormality of proline metabolism (HP:0010907)2.12111549
123Anencephaly (HP:0002323)2.11344943
124Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09253565
125Delayed CNS myelination (HP:0002188)2.08954127
126Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08567719
127Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08567719
128Nephrogenic diabetes insipidus (HP:0009806)2.08435984
129Abnormality of the labia minora (HP:0012880)2.08255096
130Aplasia/Hypoplasia of the uvula (HP:0010293)2.06388883
131Prolonged QT interval (HP:0001657)2.05363239
132EMG: myopathic abnormalities (HP:0003458)2.03209470
133Renal Fanconi syndrome (HP:0001994)2.03105156
134Ventricular fibrillation (HP:0001663)2.02383393
135Congenital hepatic fibrosis (HP:0002612)2.02083681
136Abnormal drinking behavior (HP:0030082)2.01814246
137Polydipsia (HP:0001959)2.01814246
138Progressive inability to walk (HP:0002505)2.01166371
139CNS demyelination (HP:0007305)2.01115066
140Increased hepatocellular lipid droplets (HP:0006565)2.00547637
141Hypoglycemic seizures (HP:0002173)1.99905134
142Cholelithiasis (HP:0001081)1.99810087
143Intestinal atresia (HP:0011100)1.98660272
144Tubulointerstitial nephritis (HP:0001970)1.98074329
145Deep venous thrombosis (HP:0002625)1.96941285
146Neonatal death (HP:0003811)1.96778467
147Lissencephaly (HP:0001339)1.96616356
148Exercise intolerance (HP:0003546)1.96195237
149Hypothermia (HP:0002045)1.95659303
150Sclerocornea (HP:0000647)1.95100166
151Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.94600152
152Chorioretinal atrophy (HP:0000533)1.94301021
153Bony spicule pigmentary retinopathy (HP:0007737)1.94037290
154Progressive cerebellar ataxia (HP:0002073)1.90891619
155Hyperventilation (HP:0002883)1.90198937
156Increased corneal curvature (HP:0100692)1.89925136
157Keratoconus (HP:0000563)1.89925136
158Increased serum lactate (HP:0002151)1.89579741
159Optic disc pallor (HP:0000543)1.88933591
160Aplasia/Hypoplasia of the tongue (HP:0010295)1.88345104
161Optic nerve hypoplasia (HP:0000609)1.87957189
162Cerebellar dysplasia (HP:0007033)1.84786403
163Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83799368
164Abnormality of the ileum (HP:0001549)1.82609024
165Aplasia/Hypoplasia of the fovea (HP:0008060)1.81679312
166Hypoplasia of the fovea (HP:0007750)1.81679312
167Large for gestational age (HP:0001520)1.81437246
168Genital tract atresia (HP:0001827)1.79243575
169Meckel diverticulum (HP:0002245)1.79193264
170Abnormality of the renal collecting system (HP:0004742)1.77231663
171Abnormality of macular pigmentation (HP:0008002)1.75894780
172Decreased central vision (HP:0007663)1.75860473
173Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75164157
174Postaxial foot polydactyly (HP:0001830)1.73397327
175Methylmalonic acidemia (HP:0002912)1.70247699
176Abnormal ciliary motility (HP:0012262)1.69919809
177Polyuria (HP:0000103)1.69178218
178Duplicated collecting system (HP:0000081)1.69169461
179Astigmatism (HP:0000483)1.68964494
180Abnormality of the fovea (HP:0000493)1.68502823
181Febrile seizures (HP:0002373)1.68285605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK26.86448640
2BCKDK5.15896733
3PDK44.02716697
4PDK34.02716697
5BMPR1B3.75947155
6TTN3.17454996
7MAP4K23.11954761
8TRIB32.97226686
9NEK12.85793178
10PKN22.65657613
11ADRBK22.63021951
12ZAK2.56936978
13PDK22.51512848
14ACVR1B2.33152983
15MYLK2.25460653
16PHKG12.19617842
17PHKG22.19617842
18NUAK12.19009201
19RIPK11.93257490
20GRK11.92001159
21OBSCN1.86732769
22STK391.74883561
23NTRK31.70065859
24CASK1.69740770
25ERN11.69368882
26TIE11.58174851
27PRKG21.55621365
28CAMKK21.55301413
29MST1R1.51491505
30PINK11.50016970
31INSRR1.44519009
32TNIK1.40595339
33WNK41.30436667
34NEK91.28484841
35DMPK1.26520374
36PIK3CA1.24271985
37MAPK131.22603216
38MAPKAPK31.20423410
39TRIM281.17205181
40FRK1.17047286
41KSR21.16689875
42PLK21.15861016
43CCNB11.14516163
44PRKAA11.12370920
45PRKAA21.10966567
46DYRK21.08011080
47PRKD31.06801644
48TLK11.04353252
49SGK21.03854646
50SIK11.03835263
51CAMK1D1.03118840
52STK38L1.02719479
53PNCK1.01475919
54PLK41.01294903
55NTRK21.00458444
56CSNK1G20.99660626
57VRK10.98288853
58EIF2AK30.97877587
59MAP2K70.97444831
60PRKD10.96672501
61AKT30.94885392
62PTK60.92559625
63MKNK20.91652615
64PRKCG0.91476824
65PAK30.89672440
66MAP2K60.89593519
67LATS20.88741646
68MST40.88599831
69MAP3K70.87650966
70SGK2230.86991566
71SGK4940.86991566
72TXK0.86087808
73CSNK1G10.85725785
74CSNK1G30.85364303
75MUSK0.82155598
76VRK20.81179624
77BRSK20.79283745
78CSNK1A1L0.79136518
79TEC0.78680310
80PDPK10.77248039
81TAOK30.76244765
82FLT30.76131838
83BCR0.68461242
84MAP2K10.68116599
85GRK70.67783785
86MAP3K90.67400689
87CAMK2D0.66615114
88PDGFRA0.66057541
89STK160.65243226
90ROCK10.64509939
91MAP3K20.64423644
92ERBB30.64254309
93MAPK120.62997669
94PLK30.62344905
95FGFR40.62304224
96PRKCQ0.62247815
97STK380.61139335
98LATS10.60794579
99MAPK110.60746214
100CSNK1A10.59870236
101PDK10.59670559
102MARK10.58468442
103ILK0.56940097
104MAP2K40.56385727
105PIK3CG0.55326116
106MKNK10.54853681
107STK240.54821664
108FER0.54603024
109PRKACG0.52868343
110MAP3K50.51063306
111ERBB40.49414486
112PRKCI0.48823869
113LRRK20.48706328
114MINK10.47462152
115TGFBR20.47117835
116MET0.46285612
117CHEK20.45476122
118TAF10.45188860
119WNK30.43812146
120TRPM70.43768787
121WEE10.42998080
122PAK60.42981018
123TYK20.42891840
124CDK90.40584762
125JAK20.39923249
126SGK30.39733016
127PRKG10.38130756
128DAPK30.37792403
129TGFBR10.37489544
130PRKCH0.37294122
131NME20.36799172
132SGK10.36350450
133MAP3K30.35746993
134MAPKAPK50.35633833
135DYRK30.35607112
136IRAK10.35305029
137ATR0.35254025
138NME10.34644075
139MAP3K10.34463930
140MAP2K30.33890542
141TAOK10.33849096
142PTK2B0.33371852
143NEK20.32924390
144RPS6KA50.32170034
145PRKCA0.31926946
146JAK10.31120671
147CAMK2G0.30433196
148PRKACB0.30350418
149AKT20.30161504
150PRKACA0.29603583
151CAMK2A0.28016667
152RET0.27143919
153CAMK1G0.25647838
154CAMK40.25399741
155KDR0.24073728
156DAPK20.23942005
157MAP2K20.23852863
158MAP3K40.23257313
159CAMK10.22938153
160PRKCE0.21785384
161KSR10.21514486
162RAF10.21199802
163MTOR0.20174315
164ADRBK10.19258039
165EPHA40.18030192
166OXSR10.17530437
167BRAF0.16237232

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.07616653
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.00197899
3Propanoate metabolism_Homo sapiens_hsa006403.96537830
4Fatty acid degradation_Homo sapiens_hsa000713.55338974
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.53101254
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.13794589
7Fatty acid metabolism_Homo sapiens_hsa012122.84309654
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.76346610
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.76141962
10Carbon metabolism_Homo sapiens_hsa012002.57715851
11Butanoate metabolism_Homo sapiens_hsa006502.52410917
12Pyruvate metabolism_Homo sapiens_hsa006202.46847997
13Phototransduction_Homo sapiens_hsa047442.25596995
14One carbon pool by folate_Homo sapiens_hsa006702.18340163
15Protein export_Homo sapiens_hsa030602.14713484
16Nicotine addiction_Homo sapiens_hsa050332.12143926
17PPAR signaling pathway_Homo sapiens_hsa033202.06121382
18Tryptophan metabolism_Homo sapiens_hsa003802.05324598
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90429980
20Arginine biosynthesis_Homo sapiens_hsa002201.90224800
21RNA polymerase_Homo sapiens_hsa030201.80777529
22Oxidative phosphorylation_Homo sapiens_hsa001901.80026083
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.79123865
24Linoleic acid metabolism_Homo sapiens_hsa005911.74965615
25Basal transcription factors_Homo sapiens_hsa030221.70850476
26Fanconi anemia pathway_Homo sapiens_hsa034601.67053913
27Nitrogen metabolism_Homo sapiens_hsa009101.65893785
28Homologous recombination_Homo sapiens_hsa034401.65560984
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64823217
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64507885
31Biosynthesis of amino acids_Homo sapiens_hsa012301.63962696
32Cardiac muscle contraction_Homo sapiens_hsa042601.63234469
33Parkinsons disease_Homo sapiens_hsa050121.61615399
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60334736
35Peroxisome_Homo sapiens_hsa041461.58104303
36Sulfur metabolism_Homo sapiens_hsa009201.57432602
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56507747
38Fatty acid elongation_Homo sapiens_hsa000621.53769791
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.53575137
40beta-Alanine metabolism_Homo sapiens_hsa004101.51856707
41Taste transduction_Homo sapiens_hsa047421.50478463
42Morphine addiction_Homo sapiens_hsa050321.46588703
43Regulation of autophagy_Homo sapiens_hsa041401.41224852
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34412377
45Ether lipid metabolism_Homo sapiens_hsa005651.33002761
46Starch and sucrose metabolism_Homo sapiens_hsa005001.29693576
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28804720
48RNA degradation_Homo sapiens_hsa030181.27170713
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26753444
50GABAergic synapse_Homo sapiens_hsa047271.25736638
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21221138
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14885959
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14828964
54Serotonergic synapse_Homo sapiens_hsa047261.13500466
55Olfactory transduction_Homo sapiens_hsa047401.13223005
56Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13017496
57Alzheimers disease_Homo sapiens_hsa050101.12028119
58Proteasome_Homo sapiens_hsa030501.09143269
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08938405
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07744110
61Bile secretion_Homo sapiens_hsa049761.04146491
62Fat digestion and absorption_Homo sapiens_hsa049751.04093089
63Glycerolipid metabolism_Homo sapiens_hsa005611.02261299
64Fatty acid biosynthesis_Homo sapiens_hsa000611.02224085
65Dilated cardiomyopathy_Homo sapiens_hsa054140.99450362
66Fructose and mannose metabolism_Homo sapiens_hsa000510.94797900
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.94037660
68Sulfur relay system_Homo sapiens_hsa041220.93955580
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92516799
70Phenylalanine metabolism_Homo sapiens_hsa003600.91665398
71Huntingtons disease_Homo sapiens_hsa050160.89089271
72Glutamatergic synapse_Homo sapiens_hsa047240.88945751
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88484086
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86686697
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.83431642
76Circadian entrainment_Homo sapiens_hsa047130.82761298
77Arginine and proline metabolism_Homo sapiens_hsa003300.81974490
78Galactose metabolism_Homo sapiens_hsa000520.77403151
79Lysine degradation_Homo sapiens_hsa003100.76283620
80Glucagon signaling pathway_Homo sapiens_hsa049220.75082064
81Purine metabolism_Homo sapiens_hsa002300.74624478
82Caffeine metabolism_Homo sapiens_hsa002320.74446131
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74282013
84Pentose phosphate pathway_Homo sapiens_hsa000300.71999484
85Insulin resistance_Homo sapiens_hsa049310.71043622
86Selenocompound metabolism_Homo sapiens_hsa004500.69571415
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69385662
88Tyrosine metabolism_Homo sapiens_hsa003500.66818102
89ABC transporters_Homo sapiens_hsa020100.66246047
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.65871249
91Dopaminergic synapse_Homo sapiens_hsa047280.62590613
92Arachidonic acid metabolism_Homo sapiens_hsa005900.61562818
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59009678
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.58180889
95Chemical carcinogenesis_Homo sapiens_hsa052040.58048199
96RNA transport_Homo sapiens_hsa030130.57806817
97Histidine metabolism_Homo sapiens_hsa003400.56939264
98Folate biosynthesis_Homo sapiens_hsa007900.56751509
99AMPK signaling pathway_Homo sapiens_hsa041520.55080928
100Complement and coagulation cascades_Homo sapiens_hsa046100.53981370
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53543807
102Insulin signaling pathway_Homo sapiens_hsa049100.53412733
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52950972
104Non-homologous end-joining_Homo sapiens_hsa034500.51438072
105Metabolic pathways_Homo sapiens_hsa011000.50757167
106Salivary secretion_Homo sapiens_hsa049700.50064147
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48164965
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.48109911
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47370345
110Calcium signaling pathway_Homo sapiens_hsa040200.47114381
111Pyrimidine metabolism_Homo sapiens_hsa002400.45509221
112Steroid biosynthesis_Homo sapiens_hsa001000.42676812
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41000616
114Ovarian steroidogenesis_Homo sapiens_hsa049130.40418723
115Long-term depression_Homo sapiens_hsa047300.40411341
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40173701
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39571638
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.35281930
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35029742
120Synaptic vesicle cycle_Homo sapiens_hsa047210.33711496
121Circadian rhythm_Homo sapiens_hsa047100.33153619
122Nucleotide excision repair_Homo sapiens_hsa034200.32688441
123Glutathione metabolism_Homo sapiens_hsa004800.31651321
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31166571
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30339155
126Retinol metabolism_Homo sapiens_hsa008300.29835677
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.27946204
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27489826
129Vitamin digestion and absorption_Homo sapiens_hsa049770.21156356
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.21128909
131Type II diabetes mellitus_Homo sapiens_hsa049300.19404902
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.18889928
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15968780
134Collecting duct acid secretion_Homo sapiens_hsa049660.14528455
135Mineral absorption_Homo sapiens_hsa049780.13032732
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12527681
137HIF-1 signaling pathway_Homo sapiens_hsa040660.11760350
138Insulin secretion_Homo sapiens_hsa049110.10377991
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10007454
140Gastric acid secretion_Homo sapiens_hsa049710.08180914
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07995745
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.07520957
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07445127
144Vitamin B6 metabolism_Homo sapiens_hsa007500.06621777
145Pancreatic secretion_Homo sapiens_hsa049720.05704622

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