LACTB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.66214215
2L-phenylalanine catabolic process (GO:0006559)6.66214215
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.46105636
4L-phenylalanine metabolic process (GO:0006558)6.46105636
5aromatic amino acid family catabolic process (GO:0009074)6.38522177
6indole-containing compound catabolic process (GO:0042436)6.03639521
7indolalkylamine catabolic process (GO:0046218)6.03639521
8tryptophan catabolic process (GO:0006569)6.03639521
9kynurenine metabolic process (GO:0070189)5.73396542
10glyoxylate metabolic process (GO:0046487)5.69142700
11tryptophan metabolic process (GO:0006568)5.68519391
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.47139454
13bile acid biosynthetic process (GO:0006699)5.43346290
14cysteine metabolic process (GO:0006534)5.40013223
15negative regulation of interleukin-12 production (GO:0032695)5.32846376
16urea metabolic process (GO:0019627)5.08899774
17urea cycle (GO:0000050)5.08899774
18alpha-linolenic acid metabolic process (GO:0036109)5.04057656
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.03010655
20response to peptidoglycan (GO:0032494)4.96018771
21lysine catabolic process (GO:0006554)4.87752993
22lysine metabolic process (GO:0006553)4.87752993
23complement activation, alternative pathway (GO:0006957)4.85011916
24regulation of vitamin D biosynthetic process (GO:0060556)4.84820924
25sulfur amino acid catabolic process (GO:0000098)4.82481314
26serine family amino acid catabolic process (GO:0009071)4.79458517
27peptidyl-glutamic acid carboxylation (GO:0017187)4.79015457
28protein carboxylation (GO:0018214)4.79015457
29regulation of cholesterol esterification (GO:0010872)4.77704912
30nitrogen cycle metabolic process (GO:0071941)4.77056812
31regulation of protein activation cascade (GO:2000257)4.66755609
32aromatic amino acid family metabolic process (GO:0009072)4.64313608
33negative regulation of fibrinolysis (GO:0051918)4.63172299
34high-density lipoprotein particle remodeling (GO:0034375)4.56447597
35amino-acid betaine metabolic process (GO:0006577)4.50589403
36bile acid metabolic process (GO:0008206)4.49985735
37regulation of fibrinolysis (GO:0051917)4.46784017
38regulation of complement activation (GO:0030449)4.40057633
39homocysteine metabolic process (GO:0050667)4.31269192
40alpha-amino acid catabolic process (GO:1901606)4.28348978
41regulation of triglyceride catabolic process (GO:0010896)4.27119484
42tyrosine metabolic process (GO:0006570)4.22184425
43glycine metabolic process (GO:0006544)4.21756213
44lipopolysaccharide-mediated signaling pathway (GO:0031663)4.20928837
45indolalkylamine metabolic process (GO:0006586)4.19076301
46protein-lipid complex remodeling (GO:0034368)4.19051691
47macromolecular complex remodeling (GO:0034367)4.19051691
48plasma lipoprotein particle remodeling (GO:0034369)4.19051691
49cellular biogenic amine catabolic process (GO:0042402)4.12559504
50amine catabolic process (GO:0009310)4.12559504
51serine family amino acid metabolic process (GO:0009069)4.11910016
52aldehyde catabolic process (GO:0046185)4.10802807
53cellular ketone body metabolic process (GO:0046950)4.04066509
54urate metabolic process (GO:0046415)4.03374919
55T-helper 1 type immune response (GO:0042088)4.00674507
56reverse cholesterol transport (GO:0043691)3.99420079
57plasma lipoprotein particle clearance (GO:0034381)3.98194627
58macrophage activation involved in immune response (GO:0002281)3.98076552
59regulation of T-helper 1 cell differentiation (GO:0045625)3.97779987
60phospholipid efflux (GO:0033700)3.93622151
61cellular amino acid catabolic process (GO:0009063)3.93115222
62low-density lipoprotein particle remodeling (GO:0034374)3.92381927
63negative regulation of sterol transport (GO:0032372)3.91521878
64negative regulation of cholesterol transport (GO:0032375)3.91521878
65ethanol oxidation (GO:0006069)3.90828887
66bile acid and bile salt transport (GO:0015721)3.89377647
67regulation of vitamin metabolic process (GO:0030656)3.88589036
68cellular glucuronidation (GO:0052695)3.88318563
69coenzyme catabolic process (GO:0009109)3.86956126
70acylglycerol homeostasis (GO:0055090)3.86208049
71triglyceride homeostasis (GO:0070328)3.86208049
72glutamate metabolic process (GO:0006536)3.85754315
73regulation of interferon-alpha production (GO:0032647)3.85399377
74serine family amino acid biosynthetic process (GO:0009070)3.85116855
75benzene-containing compound metabolic process (GO:0042537)3.83503458
76regulation of mononuclear cell migration (GO:0071675)3.82768394
77positive regulation of chemokine biosynthetic process (GO:0045080)3.82047866
78neutrophil activation involved in immune response (GO:0002283)3.81941899
79drug transmembrane transport (GO:0006855)3.78458259
80dicarboxylic acid biosynthetic process (GO:0043650)3.76563883
81regulation of cytokine secretion involved in immune response (GO:0002739)3.76549147
82acetyl-CoA metabolic process (GO:0006084)3.75939522
83cellular modified amino acid catabolic process (GO:0042219)3.74943639
84imidazole-containing compound metabolic process (GO:0052803)3.69163050
852-oxoglutarate metabolic process (GO:0006103)3.67749939
86oligosaccharide catabolic process (GO:0009313)3.67412261
87modulation by symbiont of host immune response (GO:0052553)3.64552242
88positive regulation by symbiont of host defense response (GO:0052509)3.64552242
89modulation by symbiont of host defense response (GO:0052031)3.64552242
90modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.64552242
91modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.64552242
92positive regulation by organism of defense response of other organism involved in symbiotic interact3.64552242
93short-chain fatty acid metabolic process (GO:0046459)3.63094458
94positive regulation of heat generation (GO:0031652)3.62851362
95detection of molecule of bacterial origin (GO:0032490)3.61540088
96NAD biosynthetic process (GO:0009435)3.60983625
97pyridine nucleotide biosynthetic process (GO:0019363)3.60005205
98nicotinamide nucleotide biosynthetic process (GO:0019359)3.60005205
99glycosphingolipid catabolic process (GO:0046479)3.59373296
100valine metabolic process (GO:0006573)3.58268602
101glucuronate metabolic process (GO:0019585)3.57811582
102uronic acid metabolic process (GO:0006063)3.57811582
103phospholipid homeostasis (GO:0055091)3.56418450
104cofactor catabolic process (GO:0051187)3.55331903
105drug catabolic process (GO:0042737)3.55294485
106NIK/NF-kappaB signaling (GO:0038061)3.55161654
107cholesterol efflux (GO:0033344)3.53206016
108regulation of podosome assembly (GO:0071801)3.52544577
109organic acid catabolic process (GO:0016054)3.52239064
110carboxylic acid catabolic process (GO:0046395)3.52239064
111regulation of chronic inflammatory response (GO:0002676)3.51938198
112fibrinolysis (GO:0042730)3.50985487
113myeloid dendritic cell differentiation (GO:0043011)3.49726546
114ketone body metabolic process (GO:1902224)3.49155836
115arginine metabolic process (GO:0006525)3.46202142
116complement activation, classical pathway (GO:0006958)3.45413728
117positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.44852358
118blood coagulation, intrinsic pathway (GO:0007597)3.44187591
119positive regulation of gamma-delta T cell activation (GO:0046645)3.43933686
120fatty acid beta-oxidation (GO:0006635)3.43627580
121regulation of interferon-beta biosynthetic process (GO:0045357)3.43333922
122carnitine metabolic process (GO:0009437)3.43323705
123cholesterol homeostasis (GO:0042632)3.43136079
124complement activation (GO:0006956)3.41053974
125sterol homeostasis (GO:0055092)3.40503157
126aspartate family amino acid catabolic process (GO:0009068)3.39673980
127fatty acid oxidation (GO:0019395)3.39509793
128immunoglobulin mediated immune response (GO:0016064)3.38486333
129regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.38331410
130cellular response to type I interferon (GO:0071357)3.38155732
131type I interferon signaling pathway (GO:0060337)3.38155732
132positive regulation of interferon-alpha production (GO:0032727)3.37984634
133positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.37983832
134plasma lipoprotein particle assembly (GO:0034377)3.37515494
135positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.36937264
136protein activation cascade (GO:0072376)3.36751041
137positive regulation of lipid catabolic process (GO:0050996)3.35982217
138response to type I interferon (GO:0034340)3.34178595
139regulation of chemokine biosynthetic process (GO:0045073)3.33574841
140regulation of fever generation (GO:0031620)3.31351006
141positive regulation of NF-kappaB import into nucleus (GO:0042346)3.30946541
142interferon-gamma-mediated signaling pathway (GO:0060333)3.28472071
143cellular response to thyroid hormone stimulus (GO:0097067)3.23390857
144glycolipid catabolic process (GO:0019377)3.23173515
145negative regulation of cytokine production involved in immune response (GO:0002719)3.20219674
146regulation of membrane protein ectodomain proteolysis (GO:0051043)3.18888000
147regulation of interleukin-12 production (GO:0032655)3.18332341
148defense response to protozoan (GO:0042832)3.18287064
149response to protozoan (GO:0001562)3.18134962
150positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.15252414
151germinal center formation (GO:0002467)3.14929033
152negative regulation of nitric oxide biosynthetic process (GO:0045019)3.09755521
153monocyte chemotaxis (GO:0002548)3.06942517
154positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.05856298
155myeloid dendritic cell activation (GO:0001773)3.05780154
156cellular response to lipopolysaccharide (GO:0071222)3.04129043
157regulation of interleukin-8 biosynthetic process (GO:0045414)3.00581153
158negative regulation of lipid storage (GO:0010888)2.99439709
159positive regulation of type 2 immune response (GO:0002830)2.99172548
160cellular response to molecule of bacterial origin (GO:0071219)2.98665936
161negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.97156879
162negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96442031
163negative regulation of cell killing (GO:0031342)2.96442031
164positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.92344360
165granulocyte activation (GO:0036230)2.91431935
166ceramide catabolic process (GO:0046514)2.89106201
167negative regulation of myeloid cell apoptotic process (GO:0033033)2.88285079
168positive regulation of interleukin-6 production (GO:0032755)2.87815665
169positive regulation of interferon-beta production (GO:0032728)2.86783874
170response to muramyl dipeptide (GO:0032495)2.86152786
171detection of other organism (GO:0098543)2.85176634
172regulation of dendritic cell antigen processing and presentation (GO:0002604)2.84945305
173cellular extravasation (GO:0045123)2.84890588
174dendritic cell differentiation (GO:0097028)2.84034051
175detection of external biotic stimulus (GO:0098581)2.81730723
176positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.80158744
177macrophage activation (GO:0042116)2.79347623
178regulation of NF-kappaB import into nucleus (GO:0042345)2.77953869
179positive regulation of monocyte chemotaxis (GO:0090026)2.77112546
180positive regulation of toll-like receptor signaling pathway (GO:0034123)2.75240001
181positive regulation of acute inflammatory response (GO:0002675)2.74259294
182regulation of nitric oxide biosynthetic process (GO:0045428)2.73901683
183regulation of T-helper 2 cell differentiation (GO:0045628)2.73306488
184cellular response to interferon-gamma (GO:0071346)2.72175107
185regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.71686110
186negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.71378849
187regulation of heat generation (GO:0031650)2.69540848
188regulation of cholesterol storage (GO:0010885)2.69533216
189myeloid cell activation involved in immune response (GO:0002275)2.69342140
190positive regulation of nitric oxide biosynthetic process (GO:0045429)2.67294308
191amino sugar catabolic process (GO:0046348)2.65574197
192modulation of growth of symbiont involved in interaction with host (GO:0044144)2.65460890
193regulation of growth of symbiont in host (GO:0044126)2.65460890
194negative regulation of growth of symbiont in host (GO:0044130)2.65460890
195negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.65460890
196regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.65352914
197regulation of T cell tolerance induction (GO:0002664)2.64899514
198B cell mediated immunity (GO:0019724)2.64174575
199regulation of interleukin-12 biosynthetic process (GO:0045075)2.63977149
200detection of biotic stimulus (GO:0009595)2.63451059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.19629773
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.31182394
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.97123732
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.47500144
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.81074743
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.42320764
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.21687337
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.48969040
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.29465637
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.03443456
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.52432800
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.35646092
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.32625799
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19558872
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.15561017
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.3662792
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95232459
18SPI1_23127762_ChIP-Seq_K562_Human1.85082159
19* IRF8_27001747_Chip-Seq_BMDM_Mouse1.80273993
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.80037619
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77429876
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77135907
23GATA1_22025678_ChIP-Seq_K562_Human1.74974128
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69253415
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67207044
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66392814
27NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.63714861
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62852799
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61021202
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54057842
31CLOCK_20551151_ChIP-Seq_293T_Human1.54004739
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.46425115
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41812692
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41345123
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41343788
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40713723
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40257832
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37411602
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27474216
40TFEB_21752829_ChIP-Seq_HELA_Human1.26330290
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24362740
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24361675
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.20603267
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.16289768
45HNF4A_19822575_ChIP-Seq_HepG2_Human1.15283028
46* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13454055
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08450079
48JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08200231
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.06426504
50RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00914194
51HTT_18923047_ChIP-ChIP_STHdh_Human1.00430195
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99057944
53ESR2_21235772_ChIP-Seq_MCF-7_Human0.98957246
54STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97482392
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94193284
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92825230
57GATA3_27048872_Chip-Seq_THYMUS_Human0.92586690
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92252127
59ELK3_25401928_ChIP-Seq_HUVEC_Human0.91167223
60STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90190582
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89565569
62SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89565569
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89322091
64GATA1_19941826_ChIP-Seq_K562_Human0.88534263
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88331454
66GATA4_25053715_ChIP-Seq_YYC3_Human0.88316561
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87833720
68STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86895048
69EGR1_19032775_ChIP-ChIP_M12_Human0.86674478
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85629863
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85544396
72CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85433105
73SCL_19346495_ChIP-Seq_HPC-7_Human0.85248588
74STAT1_20625510_ChIP-Seq_HELA_Human0.84986590
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84936952
76* MAF_26560356_Chip-Seq_TH1_Human0.84887740
77KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83145798
78NOTCH1_21737748_ChIP-Seq_TLL_Human0.81273290
79SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81227987
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80574130
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80035878
82SOX2_20726797_ChIP-Seq_SW620_Human0.79992791
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79019873
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78969982
85PU_27001747_Chip-Seq_BMDM_Mouse0.78309368
86RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77275891
87GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77241840
88* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77118580
89* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77118580
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76463530
91MAF_26560356_Chip-Seq_TH2_Human0.76352083
92SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76297810
93GATA1_19941827_ChIP-Seq_MEL_Mouse0.76062861
94MYB_26560356_Chip-Seq_TH1_Human0.75850664
95ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.73403823
96UTX_26944678_Chip-Seq_JUKART_Human0.72583726
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71254444
98STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.70988196
99RUNX_20019798_ChIP-Seq_JUKART_Human0.70311716
100FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.69659748
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69427459
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.68975404
103* SPI1_23547873_ChIP-Seq_NB4_Human0.68425440
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67373992
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.67211082
106FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.65775853
107VDR_21846776_ChIP-Seq_THP-1_Human0.65734479
108LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.65534099
109E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.65348364
110ZNF263_19887448_ChIP-Seq_K562_Human0.65117217
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.64367381
112BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64082896
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.63592009
114STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.63349040
115FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.62647183
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.62597535
117SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.62561623
118RUNX1_22412390_ChIP-Seq_EML_Mouse0.62321231
119CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.61541165
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.61064472
121SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.60367471
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.60178242
123MYB_26560356_Chip-Seq_TH2_Human0.60091339
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.59933272
125GATA3_26560356_Chip-Seq_TH2_Human0.59170821
126CEBPB_22108803_ChIP-Seq_LS180_Human0.58859383
127VDR_24787735_ChIP-Seq_THP-1_Human0.57240363
128VDR_24763502_ChIP-Seq_THP-1_Human0.56988825
129* GATA2_19941826_ChIP-Seq_K562_Human0.56546911
130FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.55676294
131RARA_24833708_ChIP-Seq_LIVER_Mouse0.55619396
132EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.55364267
133RARB_24833708_ChIP-Seq_LIVER_Mouse0.55301107

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.06424871
2MP0005360_urolithiasis6.79800141
3MP0005085_abnormal_gallbladder_physiolo5.33631720
4MP0005365_abnormal_bile_salt5.20980725
5MP0008875_abnormal_xenobiotic_pharmacok4.30689686
6MP0003806_abnormal_nucleotide_metabolis3.74512265
7MP0009840_abnormal_foam_cell3.41533069
8MP0003252_abnormal_bile_duct3.34345244
9MP0010329_abnormal_lipoprotein_level3.06440963
10MP0005332_abnormal_amino_acid2.82388224
11MP0005083_abnormal_biliary_tract2.64974800
12MP0002138_abnormal_hepatobiliary_system2.63629663
13MP0003195_calcinosis2.47507668
14MP0003191_abnormal_cellular_cholesterol2.43149399
15MP0001666_abnormal_nutrient_absorption2.19684286
16MP0003172_abnormal_lysosome_physiology2.18428528
17MP0000343_altered_response_to2.10163375
18MP0000609_abnormal_liver_physiology2.06310311
19MP0004019_abnormal_vitamin_homeostasis2.01815250
20MP0005319_abnormal_enzyme/_coenzyme1.85148660
21MP0002118_abnormal_lipid_homeostasis1.82895797
22MP0003186_abnormal_redox_activity1.81520573
23MP0001835_abnormal_antigen_presentation1.79147816
24MP0005584_abnormal_enzyme/coenzyme_acti1.72072995
25MP0006054_spinal_hemorrhage1.68375164
26MP0002998_abnormal_bone_remodeling1.57443889
27MP0003448_altered_tumor_morphology1.52996123
28MP0002405_respiratory_system_inflammati1.52562791
29MP0001764_abnormal_homeostasis1.51764128
30MP0005310_abnormal_salivary_gland1.51196222
31MP0003656_abnormal_erythrocyte_physiolo1.50381244
32MP0003868_abnormal_feces_composition1.49843090
33MP0002332_abnormal_exercise_endurance1.47434120
34MP0009643_abnormal_urine_homeostasis1.45897111
35MP0008004_abnormal_stomach_pH1.43013003
36MP0003436_decreased_susceptibility_to1.42893908
37MP0009764_decreased_sensitivity_to1.41064950
38MP0008469_abnormal_protein_level1.38139810
39MP0005451_abnormal_body_composition1.35973207
40MP0003453_abnormal_keratinocyte_physiol1.32675907
41MP0009333_abnormal_splenocyte_physiolog1.26643671
42MP0000598_abnormal_liver_morphology1.26347410
43MP0009763_increased_sensitivity_to1.25984696
44MP0000858_altered_metastatic_potential1.25854451
45MP0009278_abnormal_bone_marrow1.25733470
46MP0000604_amyloidosis1.25623067
47MP0005164_abnormal_response_to1.25193887
48MP0001545_abnormal_hematopoietic_system1.23941139
49MP0005397_hematopoietic_system_phenotyp1.23941139
50MP0003646_muscle_fatigue1.19526497
51MP0009785_altered_susceptibility_to1.19389909
52MP0009697_abnormal_copulation1.18992893
53MP0005058_abnormal_lysosome_morphology1.18532397
54MP0003828_pulmonary_edema1.10148402
55MP0006036_abnormal_mitochondrial_physio1.09439607
56MP0002419_abnormal_innate_immunity1.08346200
57MP0000685_abnormal_immune_system1.08003259
58MP0005636_abnormal_mineral_homeostasis1.07024662
59MP0002254_reproductive_system_inflammat1.06523352
60MP0005464_abnormal_platelet_physiology1.05573166
61MP0005025_abnormal_response_to1.03751384
62MP0005084_abnormal_gallbladder_morpholo1.02311050
63MP0003724_increased_susceptibility_to1.01422877
64MP0001853_heart_inflammation0.98767386
65MP0001542_abnormal_bone_strength0.98113755
66MP0005387_immune_system_phenotype0.97934204
67MP0001790_abnormal_immune_system0.97934204
68MP0004883_abnormal_blood_vessel0.97411515
69MP0003091_abnormal_cell_migration0.96791927
70MP0006082_CNS_inflammation0.95110167
71MP0005165_increased_susceptibility_to0.93939297
72MP0001800_abnormal_humoral_immune0.92432327
73MP0002398_abnormal_bone_marrow0.90391829
74MP0009642_abnormal_blood_homeostasis0.89555712
75MP0003705_abnormal_hypodermis_morpholog0.89414192
76MP0001845_abnormal_inflammatory_respons0.88789001
77MP0002877_abnormal_melanocyte_morpholog0.88340192
78MP0002148_abnormal_hypersensitivity_rea0.86401105
79MP0005390_skeleton_phenotype0.86368219
80MP0003950_abnormal_plasma_membrane0.86138135
81MP0005000_abnormal_immune_tolerance0.85188154
82MP0001663_abnormal_digestive_system0.83171935
83MP0002136_abnormal_kidney_physiology0.81545191
84MP0003011_delayed_dark_adaptation0.81310072
85MP0004130_abnormal_muscle_cell0.80666264
86MP0009765_abnormal_xenobiotic_induced0.80502236
87MP0002723_abnormal_immune_serum0.80029201
88MP0005408_hypopigmentation0.78522074
89MP0003075_altered_response_to0.77667608
90MP0002452_abnormal_antigen_presenting0.77499564
91MP0005647_abnormal_sex_gland0.76885940
92MP0001756_abnormal_urination0.76196550
93MP0008260_abnormal_autophagy0.76142885
94MP0002971_abnormal_brown_adipose0.75632007
95MP0004510_myositis0.75508758
96MP0002722_abnormal_immune_system0.75474333
97MP0005376_homeostasis/metabolism_phenot0.74021303
98MP0003303_peritoneal_inflammation0.73741340
99MP0005535_abnormal_body_temperature0.73240107
100MP0002166_altered_tumor_susceptibility0.72632451
101MP0005023_abnormal_wound_healing0.72459562
102MP0010352_gastrointestinal_tract_polyps0.72361791
103MP0000920_abnormal_myelination0.72105667
104MP0002837_dystrophic_cardiac_calcinosis0.72092346
105MP0003690_abnormal_glial_cell0.71624244
106MP0003221_abnormal_cardiomyocyte_apopto0.70678610
107MP0003300_gastrointestinal_ulcer0.70515453
108MP0005671_abnormal_response_to0.70073031
109MP0005166_decreased_susceptibility_to0.68423504
110MP0003183_abnormal_peptide_metabolism0.67352541
111MP0003795_abnormal_bone_structure0.67316616
112MP0000371_diluted_coat_color0.66725633
113MP0001873_stomach_inflammation0.65376184
114MP0006035_abnormal_mitochondrial_morpho0.64379159
115MP0005334_abnormal_fat_pad0.64331157
116MP0003279_aneurysm0.64235061
117MP0002078_abnormal_glucose_homeostasis0.63806775
118MP0003763_abnormal_thymus_physiology0.63552686
119MP0000569_abnormal_digit_pigmentation0.62624543
120MP0005266_abnormal_metabolism0.60989785
121MP0002933_joint_inflammation0.59908824
122MP0010155_abnormal_intestine_physiology0.59390880
123MP0000465_gastrointestinal_hemorrhage0.59296052
124MP0008874_decreased_physiological_sensi0.58855037
125MP0008873_increased_physiological_sensi0.58671484
126MP0000249_abnormal_blood_vessel0.58344671
127MP0001819_abnormal_immune_cell0.58003030
128MP0001661_extended_life_span0.57463967
129MP0002420_abnormal_adaptive_immunity0.57283578
130MP0004947_skin_inflammation0.57190021
131MP0005670_abnormal_white_adipose0.57082437
132MP0000689_abnormal_spleen_morphology0.56377491
133MP0010307_abnormal_tumor_latency0.55489057
134MP0002876_abnormal_thyroid_physiology0.55131705
135MP0003638_abnormal_response/metabolism_0.50669466
136MP0000716_abnormal_immune_system0.50500233
137MP0001533_abnormal_skeleton_physiology0.50288286
138MP0010368_abnormal_lymphatic_system0.48727916
139MP0005666_abnormal_adipose_tissue0.48240819
140MP0005167_abnormal_blood-brain_barrier0.48215300
141MP0002006_tumorigenesis0.47094099
142MP0003718_maternal_effect0.44392505
143MP0002429_abnormal_blood_cell0.43736528
144MP0001881_abnormal_mammary_gland0.43183382
145MP0003329_amyloid_beta_deposits0.42422113

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)7.46216676
2Abnormality of glycosphingolipid metabolism (HP:0004343)7.46216676
3Abnormality of glycolipid metabolism (HP:0010969)7.46216676
4Abnormality of aromatic amino acid family metabolism (HP:0004338)6.13589372
5Intrahepatic cholestasis (HP:0001406)6.09640094
6Deep venous thrombosis (HP:0002625)5.98161307
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.54572494
8Xanthomatosis (HP:0000991)5.51215705
9Prolonged partial thromboplastin time (HP:0003645)5.39669339
10Hypobetalipoproteinemia (HP:0003563)5.10518346
11Abnormality of macrophages (HP:0004311)4.91525068
12Hyperlipoproteinemia (HP:0010980)4.71740537
13Complement deficiency (HP:0004431)4.70911049
14Increased cerebral lipofuscin (HP:0011813)4.49152675
15Joint hemorrhage (HP:0005261)4.47607548
16Optic neuritis (HP:0100653)4.44087810
17Retrobulbar optic neuritis (HP:0100654)4.44087810
18Orchitis (HP:0100796)4.43582013
19Dysostosis multiplex (HP:0000943)4.28108900
20Eczematoid dermatitis (HP:0000976)4.27227954
21Hyperammonemia (HP:0001987)4.18278108
22Recurrent abscess formation (HP:0002722)4.04819911
23Autoimmune thrombocytopenia (HP:0001973)4.02986139
24Loss of speech (HP:0002371)4.00440245
25Abnormality of glutamine family amino acid metabolism (HP:0010902)4.00237006
26Disinhibition (HP:0000734)3.99329359
27Stomatitis (HP:0010280)3.95155338
28Ketosis (HP:0001946)3.91104589
29Hypolipoproteinemia (HP:0010981)3.90437576
30Myositis (HP:0100614)3.89066873
31Hyperglycinuria (HP:0003108)3.87846979
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.84098328
33Hyperglycinemia (HP:0002154)3.82283905
34Abnormality of aspartate family amino acid metabolism (HP:0010899)3.81384588
35Mediastinal lymphadenopathy (HP:0100721)3.78098861
36Abnormality of the common coagulation pathway (HP:0010990)3.75644643
37Epidermoid cyst (HP:0200040)3.74114023
38Abnormality of fatty-acid metabolism (HP:0004359)3.70566750
39Abnormality of glycine metabolism (HP:0010895)3.67509478
40Abnormality of serine family amino acid metabolism (HP:0010894)3.67509478
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.66253186
42Abnormality of methionine metabolism (HP:0010901)3.63575779
43Abnormality of complement system (HP:0005339)3.62138179
44Fat malabsorption (HP:0002630)3.54976258
45Increased neuronal autofluorescent lipopigment (HP:0002074)3.53024687
46Hypoglycemic coma (HP:0001325)3.50961309
47Abnormality of mucopolysaccharide metabolism (HP:0011020)3.47831464
48Abnormality of polysaccharide metabolism (HP:0011012)3.47831464
49Abnormality of glycosaminoglycan metabolism (HP:0004371)3.47831464
50Hypoalphalipoproteinemia (HP:0003233)3.47203593
51Recurrent gram-negative bacterial infections (HP:0005420)3.43775847
52Abnormality of pyrimidine metabolism (HP:0004353)3.43108598
53Systemic lupus erythematosus (HP:0002725)3.36340952
54Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36125691
55Mucopolysacchariduria (HP:0008155)3.30866405
56Urinary glycosaminoglycan excretion (HP:0003541)3.30866405
57Myocardial infarction (HP:0001658)3.24861509
58Abnormality of the intrinsic pathway (HP:0010989)3.07490045
59Hypercholesterolemia (HP:0003124)3.05939321
60Ketoacidosis (HP:0001993)3.03508277
61Abnormality of nucleobase metabolism (HP:0010932)3.00860991
62Keratoconjunctivitis sicca (HP:0001097)2.99248603
63Hyperbilirubinemia (HP:0002904)2.97308132
64Pulmonary infiltrates (HP:0002113)2.96355899
65Mutism (HP:0002300)2.92354893
66Hematochezia (HP:0002573)2.89019745
67Abnormality of serum amino acid levels (HP:0003112)2.86568945
68Conjugated hyperbilirubinemia (HP:0002908)2.86500153
69Delayed CNS myelination (HP:0002188)2.83186035
70Steatorrhea (HP:0002570)2.81002684
71Keratoconjunctivitis (HP:0001096)2.79783822
72Abnormality of purine metabolism (HP:0004352)2.79737187
73Dicarboxylic aciduria (HP:0003215)2.71862896
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.71862896
75Vascular calcification (HP:0004934)2.71445125
76Recurrent skin infections (HP:0001581)2.70907949
77Increased IgM level (HP:0003496)2.70151686
78Vasculitis (HP:0002633)2.69416917
79Metabolic acidosis (HP:0001942)2.69111296
80Elevated erythrocyte sedimentation rate (HP:0003565)2.66196734
81Hepatocellular carcinoma (HP:0001402)2.63666278
82Neurofibrillary tangles (HP:0002185)2.63646293
83Generalized aminoaciduria (HP:0002909)2.63398291
84Glomerulonephritis (HP:0000099)2.58423932
85Gout (HP:0001997)2.57880494
86Recurrent fungal infections (HP:0002841)2.57417811
87Nuclear cataract (HP:0100018)2.55950744
88Hemoptysis (HP:0002105)2.53302633
89Lethargy (HP:0001254)2.51123508
90Abnormality of the vasculature of the conjunctiva (HP:0008054)2.47468765
91Abnormality of T cell number (HP:0011839)2.45994851
92Gangrene (HP:0100758)2.44572304
93Skin nodule (HP:0200036)2.39793094
94Spastic diplegia (HP:0001264)2.38721616
95Cardiovascular calcification (HP:0011915)2.37134679
96Gingival bleeding (HP:0000225)2.36941971
97Amyloidosis (HP:0011034)2.36293805
98T lymphocytopenia (HP:0005403)2.34979075
99Obstructive lung disease (HP:0006536)2.34913158
100Chronic obstructive pulmonary disease (HP:0006510)2.34913158
101Progressive neurologic deterioration (HP:0002344)2.34525092
102Polyneuropathy (HP:0001271)2.34465810
103Metaphyseal irregularity (HP:0003025)2.32743684
104Spontaneous abortion (HP:0005268)2.32396770
105Cerebral edema (HP:0002181)2.31958607
106Purpura (HP:0000979)2.31392147
107Asymmetric septal hypertrophy (HP:0001670)2.30759025
108Inappropriate behavior (HP:0000719)2.28331261
109Apathy (HP:0000741)2.27999650
110Diminished motivation (HP:0000745)2.27711502
111Upper motor neuron abnormality (HP:0002127)2.26803406
112Arterial thrombosis (HP:0004420)2.26540807
113Esophageal varix (HP:0002040)2.22955449
114Abnormality of iron homeostasis (HP:0011031)2.21937282
115Thrombophlebitis (HP:0004418)2.21543947
116Hepatosplenomegaly (HP:0001433)2.20253293
117Proximal tubulopathy (HP:0000114)2.19051095
118Recurrent cutaneous fungal infections (HP:0011370)2.17653712
119Chronic mucocutaneous candidiasis (HP:0002728)2.17653712
120Irritability (HP:0000737)2.16154800
121Axonal loss (HP:0003447)2.15780823
122Recurrent viral infections (HP:0004429)2.15437697
123Acanthocytosis (HP:0001927)2.15136994
124Autoimmune hemolytic anemia (HP:0001890)2.14857715
125Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.14487020
126Gingivitis (HP:0000230)2.14306941
127Abnormality of transition element cation homeostasis (HP:0011030)2.13972349
128Neonatal onset (HP:0003623)2.13317175
129Urticaria (HP:0001025)2.11981012
130Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11849393
131Abnormality of urine glucose concentration (HP:0011016)2.11542071
132Glycosuria (HP:0003076)2.11542071
133Pancreatitis (HP:0001733)2.11319096
134Vomiting (HP:0002013)2.11143119
135Mitral stenosis (HP:0001718)2.09378108
136Encephalitis (HP:0002383)2.09127731
137Basal ganglia calcification (HP:0002135)2.07853238
138Petechiae (HP:0000967)2.07368947
139Prolonged neonatal jaundice (HP:0006579)2.06487202
140Interstitial pulmonary disease (HP:0006530)2.04969345
141Meningitis (HP:0001287)2.04429032
142Anorexia (HP:0002039)2.04427662
143Sensorimotor neuropathy (HP:0007141)2.02284292
144Menorrhagia (HP:0000132)2.01550474
145Leukocytosis (HP:0001974)2.01393391
146Recurrent bacterial skin infections (HP:0005406)2.01215857
147Abnormal gallbladder morphology (HP:0012437)2.00785828
148Cholelithiasis (HP:0001081)2.00736673
149Vacuolated lymphocytes (HP:0001922)1.99761795
150Nausea (HP:0002018)1.99293467
151Malnutrition (HP:0004395)1.98154939
152Agnosia (HP:0010524)1.98123254
153Increased serum ferritin (HP:0003281)1.97697349
154Hypochromic microcytic anemia (HP:0004840)1.97602663
155Abnormality of proline metabolism (HP:0010907)1.97516451
156Hydroxyprolinuria (HP:0003080)1.97516451
157Cholecystitis (HP:0001082)1.96894094
158Abnormal gallbladder physiology (HP:0012438)1.96894094
159Abnormality of the pericardium (HP:0001697)1.94509959
160Hemorrhage of the eye (HP:0011885)1.94240198
161Parakeratosis (HP:0001036)1.94107246
162Abnormal delayed hypersensitivity skin test (HP:0002963)1.90742145
163Nephritis (HP:0000123)1.90475728
164Spondylolisthesis (HP:0003302)1.89721600
165Cerebral inclusion bodies (HP:0100314)1.89293043
166Hyperuricemia (HP:0002149)1.89142002
167Increased purine levels (HP:0004368)1.89142002
168Hypergammaglobulinemia (HP:0010702)1.88739100
169Pulmonary embolism (HP:0002204)1.86862774
170Global brain atrophy (HP:0002283)1.86275642
171Glomerulopathy (HP:0100820)1.85085049
172Alkalosis (HP:0001948)1.84919035
173Hypoglycemic seizures (HP:0002173)1.84298526
174Abnormal enzyme/coenzyme activity (HP:0012379)1.84213728
175Gastrointestinal infarctions (HP:0005244)1.84104455
176Abnormality of the pleura (HP:0002103)1.83821947
177Polycythemia (HP:0001901)1.83245430
178Joint swelling (HP:0001386)1.82525562
179Opisthotonus (HP:0002179)1.81365897
180Abnormality of the endocardium (HP:0004306)1.81127991
181Elevated hepatic transaminases (HP:0002910)1.80365266
182Spontaneous hematomas (HP:0007420)1.78970182
183Bone pain (HP:0002653)1.78547853
184Episodic fever (HP:0001954)1.78026154
185Thoracic kyphosis (HP:0002942)1.76455304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.95673208
2GRK73.42588639
3ERN13.26939157
4FGFR43.17363356
5TAOK33.12653782
6TYK23.06333496
7MAP3K142.98486341
8FLT32.63005028
9BLK2.56415921
10TBK12.50890926
11DDR22.46686591
12MATK2.35637109
13TAOK22.30106485
14MAP4K12.16913183
15MAP2K32.15090177
16PKN22.09971732
17FGR2.08989025
18SIK12.02813328
19BMPR21.95094647
20MOS1.90909421
21IRAK31.89232706
22PRPF4B1.84372182
23CSF1R1.84307930
24TXK1.84303739
25NME21.82143858
26KIT1.81798162
27JAK11.72016321
28IRAK41.69604368
29ABL21.68829890
30NEK91.64761347
31ADRBK21.63973626
32IKBKE1.56908486
33JAK31.49889888
34JAK21.45286610
35ERBB41.42715290
36EPHB11.41009935
37IKBKB1.39575040
38RIPK11.35805824
39TRIB31.35160921
40KDR1.32785132
41GRK61.31757554
42MAPK111.31197952
43CDC42BPA1.30337656
44TAOK11.30069368
45TGFBR21.25293140
46MAP3K131.22839740
47MAP2K41.20451160
48INSRR1.19900653
49MAP3K111.19711816
50PIK3CG1.17831143
51MAP3K31.17644159
52PTK61.15023398
53MAP3K101.13903927
54PRKAA21.05226095
55BTK1.02556076
56RIPK40.98222916
57PIM20.97515133
58MST1R0.94054449
59EPHA30.92108455
60CSK0.91322009
61SYK0.88786752
62ACVR1B0.88260073
63MAP3K50.86556591
64ZAP700.85901410
65CAMKK20.84761200
66MAP3K70.84216346
67MARK30.83656658
68TEC0.81558074
69MAPK40.81018718
70PBK0.78554199
71LRRK20.78371660
72PRKCQ0.77532074
73CHUK0.76469088
74PIM10.76158951
75CDK40.74583397
76LYN0.73387975
77FGFR30.68804198
78CDK60.68649015
79PINK10.68093807
80HCK0.67630821
81FES0.66822987
82DYRK1B0.63099022
83MAP3K60.62726367
84EIF2AK10.58363822
85MAPK120.58360127
86DYRK30.58125510
87STK100.58010546
88STK40.57293695
89PDPK10.56724759
90LCK0.56687214
91IRAK20.56543884
92NLK0.56164407
93STK30.54929092
94EGFR0.54306191
95SCYL20.53797080
96TRPM70.53488154
97MAP3K80.51475294
98ITK0.49403496
99ABL10.48877831
100CLK10.47433762
101TTN0.46300179
102SIK30.43724260
103PRKAA10.43522561
104MAPK70.43261896
105PDK10.43110129
106ARAF0.40962051
107PDGFRB0.40910476
108PDK20.40879875
109RET0.40385442
110PKN10.38384136
111GSK3A0.38348258
112MAP2K60.37514227
113RPS6KA40.37141433
114TIE10.36637477
115RPS6KL10.36122152
116RPS6KC10.36122152
117LATS20.35691052
118PRKACG0.35659563
119PRKCD0.35492207
120MAP2K20.35287214
121PAK40.35162654
122RAF10.33359028
123STK240.33096218
124TESK20.32435098
125BMX0.32228709
126IRAK10.31987349
127CAMK1D0.31924777
128INSR0.31640529
129MST40.31351358
130PDGFRA0.30769176
131RPS6KA60.30718822
132OBSCN0.30636491
133HIPK20.30621530
134MAP3K10.30457499
135LIMK10.28625582
136DAPK20.27740325
137KSR10.26568829
138RPS6KA20.25437159
139MAPKAPK20.25272725
140DAPK30.22650871

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.32594687
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.53245741
3Nitrogen metabolism_Homo sapiens_hsa009103.38983624
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35427076
5Arginine biosynthesis_Homo sapiens_hsa002202.84924270
6Rheumatoid arthritis_Homo sapiens_hsa053232.73353861
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68422961
8Tryptophan metabolism_Homo sapiens_hsa003802.66740962
9Complement and coagulation cascades_Homo sapiens_hsa046102.60476726
10Fatty acid degradation_Homo sapiens_hsa000712.54160712
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.48910459
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48834316
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45595041
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.42461691
15Asthma_Homo sapiens_hsa053102.36964431
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19629337
17Peroxisome_Homo sapiens_hsa041462.17823069
18TNF signaling pathway_Homo sapiens_hsa046682.17580351
19Butanoate metabolism_Homo sapiens_hsa006502.08005450
20Staphylococcus aureus infection_Homo sapiens_hsa051502.05493114
21Propanoate metabolism_Homo sapiens_hsa006401.99413375
22Autoimmune thyroid disease_Homo sapiens_hsa053201.97015118
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.90065627
24beta-Alanine metabolism_Homo sapiens_hsa004101.83308939
25PPAR signaling pathway_Homo sapiens_hsa033201.83291634
26Caffeine metabolism_Homo sapiens_hsa002321.81191477
27Histidine metabolism_Homo sapiens_hsa003401.80792866
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77823147
29Fatty acid metabolism_Homo sapiens_hsa012121.74469986
30Chemical carcinogenesis_Homo sapiens_hsa052041.71484657
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69743536
32Type I diabetes mellitus_Homo sapiens_hsa049401.66523012
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.66269609
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.65686463
35Toxoplasmosis_Homo sapiens_hsa051451.63117374
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61297281
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.60936228
38Salmonella infection_Homo sapiens_hsa051321.58356849
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55933849
40Antigen processing and presentation_Homo sapiens_hsa046121.52435853
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.50893829
42Retinol metabolism_Homo sapiens_hsa008301.50884621
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49635839
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47569654
45Selenocompound metabolism_Homo sapiens_hsa004501.47081093
46Phenylalanine metabolism_Homo sapiens_hsa003601.46345045
47Phagosome_Homo sapiens_hsa041451.45914609
48Hematopoietic cell lineage_Homo sapiens_hsa046401.41004001
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39215242
50Bile secretion_Homo sapiens_hsa049761.35439351
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.33504320
52Folate biosynthesis_Homo sapiens_hsa007901.33359021
53Starch and sucrose metabolism_Homo sapiens_hsa005001.30835222
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30119577
55Pyruvate metabolism_Homo sapiens_hsa006201.27644852
56Fatty acid elongation_Homo sapiens_hsa000621.24528527
57Tyrosine metabolism_Homo sapiens_hsa003501.23573298
58Herpes simplex infection_Homo sapiens_hsa051681.21103665
59Jak-STAT signaling pathway_Homo sapiens_hsa046301.21043754
60Carbon metabolism_Homo sapiens_hsa012001.19948146
61Viral myocarditis_Homo sapiens_hsa054161.17154744
62Biosynthesis of amino acids_Homo sapiens_hsa012301.14921245
63Chemokine signaling pathway_Homo sapiens_hsa040621.12215187
64Sulfur metabolism_Homo sapiens_hsa009201.11472753
65Sulfur relay system_Homo sapiens_hsa041221.08355381
66Steroid biosynthesis_Homo sapiens_hsa001001.07224184
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06824509
68ABC transporters_Homo sapiens_hsa020101.03825858
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02175142
70Hepatitis B_Homo sapiens_hsa051611.00626693
71Shigellosis_Homo sapiens_hsa051310.99801868
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98337584
73Vitamin digestion and absorption_Homo sapiens_hsa049770.97996686
74Arginine and proline metabolism_Homo sapiens_hsa003300.95516521
75Amoebiasis_Homo sapiens_hsa051460.95050314
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93798850
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93277501
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.90685231
79Fat digestion and absorption_Homo sapiens_hsa049750.87875793
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87080085
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86414956
82One carbon pool by folate_Homo sapiens_hsa006700.86328597
83Apoptosis_Homo sapiens_hsa042100.86133737
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81919009
85Bladder cancer_Homo sapiens_hsa052190.80126987
86Primary immunodeficiency_Homo sapiens_hsa053400.76520879
87Acute myeloid leukemia_Homo sapiens_hsa052210.76432294
88Vitamin B6 metabolism_Homo sapiens_hsa007500.75183765
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74978186
90Glutathione metabolism_Homo sapiens_hsa004800.74715596
91Pentose phosphate pathway_Homo sapiens_hsa000300.74305918
92Sphingolipid metabolism_Homo sapiens_hsa006000.73990813
93Collecting duct acid secretion_Homo sapiens_hsa049660.72084924
94T cell receptor signaling pathway_Homo sapiens_hsa046600.71586527
95Lysine degradation_Homo sapiens_hsa003100.70328551
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68684845
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68601665
98Glycerolipid metabolism_Homo sapiens_hsa005610.67577797
99Prolactin signaling pathway_Homo sapiens_hsa049170.65369679
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64452430
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61980865
102Epstein-Barr virus infection_Homo sapiens_hsa051690.54602702
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.52182213
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.48561968
105Mineral absorption_Homo sapiens_hsa049780.43942202
106Metabolic pathways_Homo sapiens_hsa011000.43138821
107HIF-1 signaling pathway_Homo sapiens_hsa040660.42805688
108VEGF signaling pathway_Homo sapiens_hsa043700.40810337
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.39263163
110Prion diseases_Homo sapiens_hsa050200.38424871
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36144564
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35008483
113Type II diabetes mellitus_Homo sapiens_hsa049300.33436542
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.33333030
115Vibrio cholerae infection_Homo sapiens_hsa051100.33282719
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.31267908
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29590881
118Dorso-ventral axis formation_Homo sapiens_hsa043200.28620678
119Platelet activation_Homo sapiens_hsa046110.27823371
120Insulin resistance_Homo sapiens_hsa049310.27058163
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26729139
122Pancreatic cancer_Homo sapiens_hsa052120.26360620
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24477906
124Galactose metabolism_Homo sapiens_hsa000520.23850986
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.23134570
126Fructose and mannose metabolism_Homo sapiens_hsa000510.23025977
127HTLV-I infection_Homo sapiens_hsa051660.22841197
128Renal cell carcinoma_Homo sapiens_hsa052110.22764370
129Fatty acid biosynthesis_Homo sapiens_hsa000610.22558762
130Viral carcinogenesis_Homo sapiens_hsa052030.22146390
131FoxO signaling pathway_Homo sapiens_hsa040680.21915733
132Systemic lupus erythematosus_Homo sapiens_hsa053220.21316254
133Leishmaniasis_Homo sapiens_hsa051400.20543221
134Pertussis_Homo sapiens_hsa051330.20452903
135Chronic myeloid leukemia_Homo sapiens_hsa052200.18511054
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.17135048
137Endocytosis_Homo sapiens_hsa041440.16474364
138Legionellosis_Homo sapiens_hsa051340.16396727
139Proteoglycans in cancer_Homo sapiens_hsa052050.15854694
140NF-kappa B signaling pathway_Homo sapiens_hsa040640.15523676
141Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.15402896
142MAPK signaling pathway_Homo sapiens_hsa040100.14081263
143Allograft rejection_Homo sapiens_hsa053300.13916937
144Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11919637
145Other glycan degradation_Homo sapiens_hsa005110.10716183
146Lysosome_Homo sapiens_hsa041420.08205170
147Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07163008
148Glycosaminoglycan degradation_Homo sapiens_hsa005310.05290784
149NOD-like receptor signaling pathway_Homo sapiens_hsa046210.05061818
150Hepatitis C_Homo sapiens_hsa051600.04814530
151B cell receptor signaling pathway_Homo sapiens_hsa046620.04351848
152Osteoclast differentiation_Homo sapiens_hsa043800.03504770
153Renin-angiotensin system_Homo sapiens_hsa046140.02269083
154Graft-versus-host disease_Homo sapiens_hsa053320.00624394
155Measles_Homo sapiens_hsa051620.00595051
156African trypanosomiasis_Homo sapiens_hsa051430.00119367
157Tuberculosis_Homo sapiens_hsa05152-0.0421048
158Influenza A_Homo sapiens_hsa05164-0.0309440
159Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0162467
160alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0148149
161Malaria_Homo sapiens_hsa05144-0.0032664

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