LACTBL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal rod cell development (GO:0046548)9.87636887
2negative regulation of cytosolic calcium ion concentration (GO:0051481)8.93258042
3response to pheromone (GO:0019236)8.46040438
4G-protein coupled glutamate receptor signaling pathway (GO:0007216)7.36060402
5cellular potassium ion homeostasis (GO:0030007)7.24586320
6sodium ion export (GO:0071436)6.54105190
7relaxation of smooth muscle (GO:0044557)6.52662684
8positive regulation of synapse maturation (GO:0090129)6.51550160
9potassium ion homeostasis (GO:0055075)6.42293912
10synaptic vesicle endocytosis (GO:0048488)5.77859140
11synaptic vesicle exocytosis (GO:0016079)5.39381929
12retinal cone cell development (GO:0046549)5.32174987
13striatum development (GO:0021756)5.22769328
14eye photoreceptor cell development (GO:0042462)5.18052121
15photoreceptor cell development (GO:0042461)5.17791725
16mating behavior (GO:0007617)5.14135081
17regulation of synapse maturation (GO:0090128)5.07673043
18innervation (GO:0060384)5.01896213
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.96262499
20gamma-aminobutyric acid signaling pathway (GO:0007214)4.96260351
21rhodopsin mediated signaling pathway (GO:0016056)4.85609490
22urinary tract smooth muscle contraction (GO:0014848)4.76067896
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.74666787
24photoreceptor cell maintenance (GO:0045494)4.68816884
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.58353184
26protein localization to synapse (GO:0035418)4.51762591
27substrate-independent telencephalic tangential migration (GO:0021826)4.37034159
28substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.37034159
29positive regulation of dendritic spine morphogenesis (GO:0061003)4.34423207
30regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.30396417
31regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.30396417
32cellular sodium ion homeostasis (GO:0006883)4.29447732
33potassium ion export (GO:0071435)4.24444813
34regulation of rhodopsin mediated signaling pathway (GO:0022400)4.21097153
35cell communication by electrical coupling (GO:0010644)4.17120423
36regulation of synaptic vesicle exocytosis (GO:2000300)4.13053556
37prepulse inhibition (GO:0060134)4.09129462
38calcium ion import (GO:0070509)4.07842597
39synaptic vesicle maturation (GO:0016188)4.06351770
40regulation of short-term neuronal synaptic plasticity (GO:0048172)3.98317951
41sensory perception of light stimulus (GO:0050953)3.96454593
42visual perception (GO:0007601)3.93597277
43peristalsis (GO:0030432)3.92045563
44phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.88076918
45neurotransmitter-gated ion channel clustering (GO:0072578)3.85939588
46peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.80049253
47establishment of synaptic vesicle localization (GO:0097480)3.79398118
48synaptic vesicle transport (GO:0048489)3.79398118
49detection of visible light (GO:0009584)3.71963966
50positive regulation of gastrulation (GO:2000543)3.69201058
51membrane hyperpolarization (GO:0060081)3.64677726
52detection of light stimulus (GO:0009583)3.59970007
53glycolytic process (GO:0006096)3.59580869
54long term synaptic depression (GO:0060292)3.56308749
55positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.55598754
56protein-chromophore linkage (GO:0018298)3.52039549
57axon cargo transport (GO:0008088)3.48044777
58response to histamine (GO:0034776)3.42340287
59atrial cardiac muscle cell action potential (GO:0086014)3.40904871
60regulation of bile acid biosynthetic process (GO:0070857)3.40130024
61positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.37144305
62membrane depolarization during action potential (GO:0086010)3.35517438
63retina development in camera-type eye (GO:0060041)3.34773696
64synapse assembly (GO:0007416)3.33555414
65nonmotile primary cilium assembly (GO:0035058)3.31010034
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.29590083
67nitric oxide mediated signal transduction (GO:0007263)3.26596241
68response to host (GO:0075136)3.26492123
69response to host defenses (GO:0052200)3.26492123
70response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.26492123
71regulation of voltage-gated calcium channel activity (GO:1901385)3.24139906
72anterograde axon cargo transport (GO:0008089)3.23471570
73glutamate receptor signaling pathway (GO:0007215)3.20335155
74behavioral response to cocaine (GO:0048148)3.19783644
75synaptic transmission, dopaminergic (GO:0001963)3.19207825
76dentate gyrus development (GO:0021542)3.19096159
77regulation of synaptic vesicle transport (GO:1902803)3.15807857
78positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.15471803
79iron coordination entity transport (GO:1901678)3.13981725
80regulation of transforming growth factor beta2 production (GO:0032909)3.11863593
81positive regulation of TOR signaling (GO:0032008)3.08813297
82regulation of synapse structural plasticity (GO:0051823)3.05470427
83regulation of neurotransmitter uptake (GO:0051580)3.04275123
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03868229
85response to host immune response (GO:0052572)3.02329428
86response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.02329428
87sialylation (GO:0097503)2.99925324
88behavioral response to ethanol (GO:0048149)2.98917112
89positive regulation of potassium ion transmembrane transport (GO:1901381)2.97425898
90potassium ion import (GO:0010107)2.97303215
91retinal ganglion cell axon guidance (GO:0031290)2.96911059
92regulation of cardioblast proliferation (GO:0003264)2.95951377
93regulation of secondary heart field cardioblast proliferation (GO:0003266)2.95951377
94potassium ion transmembrane transport (GO:0071805)2.95529149
95cellular potassium ion transport (GO:0071804)2.95529149
96long-term synaptic potentiation (GO:0060291)2.93704918
97lactate metabolic process (GO:0006089)2.93549469
98pyrimidine dimer repair (GO:0006290)2.91210890
99detection of light stimulus involved in visual perception (GO:0050908)12.1725441
100detection of light stimulus involved in sensory perception (GO:0050962)12.1725441

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.22699860
2GBX2_23144817_ChIP-Seq_PC3_Human4.09823123
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.42478684
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.16980022
5REST_21632747_ChIP-Seq_MESCs_Mouse2.77379933
6DROSHA_22980978_ChIP-Seq_HELA_Human2.75723750
7EZH2_27294783_Chip-Seq_ESCs_Mouse2.62375339
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47005922
9SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40707868
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.38606458
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35072872
12P53_22127205_ChIP-Seq_FIBROBLAST_Human2.34244638
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32499428
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31439158
15AR_21572438_ChIP-Seq_LNCaP_Human2.31016585
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.30347936
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.30171748
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.16961979
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.16777734
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12144291
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12097584
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03262303
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94900300
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94473516
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94235811
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94013816
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91621641
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90384269
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90384269
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87192128
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84534242
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82267207
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.70317439
34FUS_26573619_Chip-Seq_HEK293_Human1.68891536
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67863069
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64192349
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63988104
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.63940461
39CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.61554144
40SMAD4_21799915_ChIP-Seq_A2780_Human1.61240822
41IGF1R_20145208_ChIP-Seq_DFB_Human1.57350156
42TAF15_26573619_Chip-Seq_HEK293_Human1.53277456
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52704306
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.51959374
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.46095937
46TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45551516
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45495283
48RNF2_27304074_Chip-Seq_NSC_Mouse1.43549206
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.40304936
50AR_19668381_ChIP-Seq_PC3_Human1.35675224
51RING1B_27294783_Chip-Seq_ESCs_Mouse1.33391645
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31835462
53RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29201538
54P300_19829295_ChIP-Seq_ESCs_Human1.29093122
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28665313
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.28121822
57AR_25329375_ChIP-Seq_VCAP_Human1.27216920
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26780523
59FLI1_21867929_ChIP-Seq_TH2_Mouse1.25444340
60SMAD3_21741376_ChIP-Seq_HESCs_Human1.24932929
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23763832
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20978055
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.20085026
64STAT3_23295773_ChIP-Seq_U87_Human1.19912356
65YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18402080
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17242506
67SMAD4_21741376_ChIP-Seq_HESCs_Human1.17185093
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17175578
69CBP_20019798_ChIP-Seq_JUKART_Human1.17175578
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17069080
71NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.12981648
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.12182506
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12016395
74TCF4_23295773_ChIP-Seq_U87_Human1.11457298
75TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09489732
76SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08882404
77ELK4_26923725_Chip-Seq_MESODERM_Mouse1.07896950
78CBP_21632823_ChIP-Seq_H3396_Human1.04140759
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04000514
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03553706
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03285334
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03185555
83OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01127406
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01084551
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01084407
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99487530
87CTCF_27219007_Chip-Seq_Bcells_Human0.98541626
88ER_23166858_ChIP-Seq_MCF-7_Human0.96876173
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96263500
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96165762
91NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96038563
92VDR_22108803_ChIP-Seq_LS180_Human0.95889045
93GATA1_26923725_Chip-Seq_HPCs_Mouse0.95740727
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94700046
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94051691
96TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92461110
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92002086
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91993276
99WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91961100
100SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90196040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog7.58923942
2MP0006072_abnormal_retinal_apoptosis5.46835615
3MP0002090_abnormal_vision5.15675330
4MP0001984_abnormal_olfaction4.09589142
5MP0005253_abnormal_eye_physiology3.96057201
6MP0004782_abnormal_surfactant_physiolog3.59410821
7MP0004233_abnormal_muscle_weight3.26962326
8MP0003011_delayed_dark_adaptation3.12726093
9MP0001502_abnormal_circadian_rhythm3.03244995
10MP0005195_abnormal_posterior_eye2.96889757
11MP0006292_abnormal_olfactory_placode2.85050905
12MP0005248_abnormal_Harderian_gland2.66224831
13MP0001346_abnormal_lacrimal_gland2.55577601
14MP0010386_abnormal_urinary_bladder2.34399396
15MP0003950_abnormal_plasma_membrane2.10606453
16MP0001324_abnormal_eye_pigmentation2.04214774
17MP0005394_taste/olfaction_phenotype2.03050857
18MP0005499_abnormal_olfactory_system2.03050857
19MP0008789_abnormal_olfactory_epithelium1.98420861
20MP0002229_neurodegeneration1.95624165
21MP0004215_abnormal_myocardial_fiber1.90536910
22MP0008775_abnormal_heart_ventricle1.89739436
23MP0002638_abnormal_pupillary_reflex1.89629357
24MP0003880_abnormal_central_pattern1.85711076
25MP0005670_abnormal_white_adipose1.85331323
26MP0004084_abnormal_cardiac_muscle1.78558545
27MP0002332_abnormal_exercise_endurance1.76611012
28MP0005391_vision/eye_phenotype1.76213127
29MP0004036_abnormal_muscle_relaxation1.74284504
30MP0001486_abnormal_startle_reflex1.72763989
31MP0002752_abnormal_somatic_nervous1.65021812
32MP0010030_abnormal_orbit_morphology1.64449497
33MP0009046_muscle_twitch1.59374127
34MP0005423_abnormal_somatic_nervous1.58770682
35MP0003635_abnormal_synaptic_transmissio1.58114203
36MP0001188_hyperpigmentation1.57529715
37MP0002234_abnormal_pharynx_morphology1.53709567
38MP0002184_abnormal_innervation1.53509148
39MP0000631_abnormal_neuroendocrine_gland1.51520289
40MP0002272_abnormal_nervous_system1.47663248
41MP0002064_seizures1.45425459
42MP0002067_abnormal_sensory_capabilities1.44604029
43MP0005595_abnormal_vascular_smooth1.36828101
44MP0010368_abnormal_lymphatic_system1.26947368
45MP0002882_abnormal_neuron_morphology1.26117778
46MP0002063_abnormal_learning/memory/cond1.24107361
47MP0002909_abnormal_adrenal_gland1.17213388
48MP0002734_abnormal_mechanical_nocicepti1.15395601
49MP0004145_abnormal_muscle_electrophysio1.12289372
50MP0008569_lethality_at_weaning1.10556020
51MP0003879_abnormal_hair_cell1.08957929
52MP0001968_abnormal_touch/_nociception1.08673284
53MP0009745_abnormal_behavioral_response1.06424166
54MP0002822_catalepsy1.04771399
55MP0002653_abnormal_ependyma_morphology1.04722441
56MP0004859_abnormal_synaptic_plasticity1.00116104
57MP0005220_abnormal_exocrine_pancreas0.97439719
58MP0003137_abnormal_impulse_conducting0.92667868
59MP0003868_abnormal_feces_composition0.91895692
60MP0002572_abnormal_emotion/affect_behav0.90381565
61MP0004043_abnormal_pH_regulation0.87273490
62MP0003634_abnormal_glial_cell0.80538915
63MP0004742_abnormal_vestibular_system0.79223817
64MP0003890_abnormal_embryonic-extraembry0.78308149
65MP0002736_abnormal_nociception_after0.77825371
66MP0001529_abnormal_vocalization0.77492506
67MP0001501_abnormal_sleep_pattern0.76896283
68MP0000955_abnormal_spinal_cord0.76210245
69MP0008260_abnormal_autophagy0.72911746
70MP0005620_abnormal_muscle_contractility0.71479578
71MP0002697_abnormal_eye_size0.66378778
72MP0004811_abnormal_neuron_physiology0.66032650
73MP0004085_abnormal_heartbeat0.65527590
74MP0000534_abnormal_ureter_morphology0.63211209
75MP0004924_abnormal_behavior0.60455794
76MP0005386_behavior/neurological_phenoty0.60455794
77MP0002557_abnormal_social/conspecific_i0.60293138
78MP0002069_abnormal_eating/drinking_beha0.58998261
79MP0004142_abnormal_muscle_tone0.57383847
80MP0003329_amyloid_beta_deposits0.57001212
81MP0002152_abnormal_brain_morphology0.56473854
82MP0002066_abnormal_motor_capabilities/c0.55601120
83MP0002751_abnormal_autonomic_nervous0.55583141
84MP0003172_abnormal_lysosome_physiology0.54456729
85MP0002089_abnormal_postnatal_growth/wei0.53667796
86MP0000751_myopathy0.53386048
87MP0000230_abnormal_systemic_arterial0.53375512
88MP0003633_abnormal_nervous_system0.50962604
89MP0004885_abnormal_endolymph0.49417402
90MP0008872_abnormal_physiological_respon0.49409013
91MP0001963_abnormal_hearing_physiology0.49059934
92MP0006035_abnormal_mitochondrial_morpho0.48911532
93MP0002269_muscular_atrophy0.48821428
94MP0004270_analgesia0.48088470
95MP0002127_abnormal_cardiovascular_syste0.47839079
96MP0009697_abnormal_copulation0.47808852
97MP0008004_abnormal_stomach_pH0.47397061
98MP0005646_abnormal_pituitary_gland0.46482674
99MP0000778_abnormal_nervous_system0.44684553
100MP0001970_abnormal_pain_threshold0.44276594

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)9.38562099
2Abnormality of macular pigmentation (HP:0008002)8.56755662
3Severe visual impairment (HP:0001141)8.33986711
4Abnormal rod and cone electroretinograms (HP:0008323)7.38113256
5Scotoma (HP:0000575)6.56332966
6Septo-optic dysplasia (HP:0100842)6.42163076
7Decreased central vision (HP:0007663)5.97157550
8Bony spicule pigmentary retinopathy (HP:0007737)5.71395758
9Albinism (HP:0001022)4.49557122
10Aplasia/Hypoplasia of the fovea (HP:0008060)4.46671574
11Hypoplasia of the fovea (HP:0007750)4.46671574
12Increased corneal curvature (HP:0100692)4.38116026
13Keratoconus (HP:0000563)4.38116026
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.79224111
15Abnormality of the fovea (HP:0000493)3.74760244
16Abnormal gallbladder physiology (HP:0012438)3.72675623
17Cholecystitis (HP:0001082)3.72675623
18Pendular nystagmus (HP:0012043)3.71842224
19Epileptic encephalopathy (HP:0200134)3.64375169
20Attenuation of retinal blood vessels (HP:0007843)3.55989617
21Febrile seizures (HP:0002373)3.51577125
22Absence seizures (HP:0002121)3.46778407
23Absent septum pellucidum (HP:0001331)3.30526733
24Optic nerve hypoplasia (HP:0000609)3.21173983
25Abolished electroretinogram (ERG) (HP:0000550)3.08307168
26Aplasia/Hypoplasia of the macula (HP:0008059)3.06465096
27Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.93359143
28Photophobia (HP:0000613)2.89631569
29Aplasia/Hypoplasia affecting the retina (HP:0008061)2.88612921
30Abnormality of the septum pellucidum (HP:0007375)2.85438692
31Chorioretinal atrophy (HP:0000533)2.79211262
32Severe Myopia (HP:0011003)2.77611447
33Dialeptic seizures (HP:0011146)2.74454641
34Pigmentary retinal degeneration (HP:0001146)2.71538228
35Dyschromatopsia (HP:0007641)2.66562900
36Type II diabetes mellitus (HP:0005978)2.59847647
37Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.55270130
38Prolonged QT interval (HP:0001657)2.55246016
39Progressive cerebellar ataxia (HP:0002073)2.53119181
40Cone-rod dystrophy (HP:0000548)2.51326650
41Abnormal pupillary function (HP:0007686)2.43646149
42Hemiparesis (HP:0001269)2.43553057
43Generalized hypopigmentation (HP:0007513)2.42728507
44Abnormality of the sella turcica (HP:0002679)2.40939445
45Retinitis pigmentosa (HP:0000510)2.36406988
46Constricted visual fields (HP:0001133)2.30240164
47Mutism (HP:0002300)2.25625163
48Growth hormone deficiency (HP:0000824)2.21073762
49Dysdiadochokinesis (HP:0002075)2.20619585
50Congenital sensorineural hearing impairment (HP:0008527)2.16222673
51Abnormality of abdominal situs (HP:0011620)2.11518741
52Abdominal situs inversus (HP:0003363)2.11518741
53Gait imbalance (HP:0002141)2.10548988
54Choroideremia (HP:0001139)2.09682936
55Visual hallucinations (HP:0002367)2.02036678
56Congenital primary aphakia (HP:0007707)2.01330741
57Neoplasm of the heart (HP:0100544)2.01218382
58Congenital stationary night blindness (HP:0007642)17.3692508
59EEG with generalized epileptiform discharges (HP:0011198)1.96887144
60Epileptiform EEG discharges (HP:0011182)1.87800973
61Macular degeneration (HP:0000608)1.83509648
62Nephrogenic diabetes insipidus (HP:0009806)1.83075810
63Astigmatism (HP:0000483)1.81532527
64Aplasia/Hypoplasia of the tongue (HP:0010295)1.77661751
65Medial flaring of the eyebrow (HP:0010747)1.76622869
66Poor coordination (HP:0002370)1.75675694
67Depression (HP:0000716)1.75614681
68Chorioretinal coloboma (HP:0000567)1.70157546
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68508291
70Primary adrenal insufficiency (HP:0008207)1.67962534
71Ventricular fibrillation (HP:0001663)1.66964520
72Partial agenesis of the corpus callosum (HP:0001338)1.66793190
73Generalized tonic-clonic seizures (HP:0002069)1.66667145
74Abnormal EKG (HP:0003115)1.65110359
75True hermaphroditism (HP:0010459)1.63850695
76Posterior subcapsular cataract (HP:0007787)1.62580986
77Atrial fibrillation (HP:0005110)1.60816692
78Genetic anticipation (HP:0003743)1.59988067
79Cerebellar dysplasia (HP:0007033)1.58588328
80Unsteady gait (HP:0002317)1.56538988
81Optic disc pallor (HP:0000543)1.56521066
82Scanning speech (HP:0002168)1.46530620
83Increased neuronal autofluorescent lipopigment (HP:0002074)1.46504886
84Dysmetric saccades (HP:0000641)1.46019008
85Primary atrial arrhythmia (HP:0001692)1.44293186
86Flat cornea (HP:0007720)1.39487037
87Fatigue (HP:0012378)1.39388262
88Syncope (HP:0001279)1.39156569
89Decreased electroretinogram (ERG) amplitude (HP:0000654)1.37702813
90Supraventricular tachycardia (HP:0004755)1.36617196
91Progressive visual loss (HP:0000529)1.35929112
92Abnormality of the lower motor neuron (HP:0002366)1.35765623
93Exercise-induced myalgia (HP:0003738)1.34332493
94Maternal diabetes (HP:0009800)1.33877644
95Ankle clonus (HP:0011448)1.33554962
96Long toe (HP:0010511)1.33154429
97Genital tract atresia (HP:0001827)1.32810644
98Action tremor (HP:0002345)1.31023648
99Left ventricular hypertrophy (HP:0001712)1.30684744
100Supraventricular arrhythmia (HP:0005115)1.30613147

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.41132394
2PAK63.95209179
3NEK13.77735944
4MAP3K43.19974932
5PRPF4B3.19538658
6TAOK23.15115632
7EPHA32.70331875
8DYRK1A2.51551240
9INSRR2.43585203
10NME12.36444698
11PHKG22.33621212
12PHKG12.33621212
13RIPK12.26584762
14MINK12.16112949
15MAP3K92.11537170
16STK381.99227726
17GRK11.92131298
18MARK11.86879859
19MAP3K71.69587068
20TNK21.68393361
21MAP3K131.66167849
22FES1.60526847
23STK38L1.56872088
24CDK31.50190166
25CAMK2D1.44354833
26FER1.32214923
27CLK11.32182510
28CDK81.31155302
29PINK11.22890780
30PRKAA11.14580316
31CAMK1D1.14418262
32IRAK21.08081010
33EPHA41.07554465
34TNIK0.97425201
35CDK140.97105388
36ROCK20.96570458
37SGK2230.94945042
38SGK4940.94945042
39CAMK10.86880423
40CAMK1G0.86382754
41BRD40.84190366
42CDK150.78194032
43PAK30.77092395
44CDK90.74652518
45CDK50.72687420
46CDK180.72640162
47PRKG20.72536105
48KSR20.71895508
49CDK11A0.71190669
50ERBB30.71151799
51MAP2K70.69619443
52PKN10.66849880
53PLK30.66500285
54MAPK100.66443113
55PRKG10.66423463
56PRKCZ0.65039506
57PRKCE0.62883198
58PRKCA0.62457314
59WNK30.60946815
60CAMK2A0.60613783
61PRKCG0.59906927
62MAP3K60.59666051
63PRKCB0.59099620
64PRKD20.58093020
65NEK20.58027496
66RPS6KA30.57911622
67CAMKK10.56818457
68TAOK30.56678628
69DYRK1B0.55599749
70KSR10.53641027
71MARK20.52404239
72GSK3B0.51582587
73ROCK10.50404586
74PRKACA0.48922200
75ARAF0.47467411
76RPS6KA50.45804715
77BCKDK0.43404378
78FGFR10.43337980
79AKT30.42440688
80MAPK80.42242586
81PRKACB0.42135720
82SIK20.41942353
83MAPK90.40799454
84SIK10.40507687
85PKN20.37947709
86PRKD30.37941950
87ERBB20.37919878
88BMX0.37679490
89AKT20.35332467
90PRKACG0.34976586
91MAPK140.34739322
92RPS6KB20.34122551
93HIPK20.33102371
94LMTK20.32961614
95CDC42BPA0.32574874
96CDK10.31970131
97CHEK20.31256782
98CAMK40.31159749
99MAP2K40.30882074
100AKT10.29103278

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.57124311
2Nicotine addiction_Homo sapiens_hsa050334.30591540
3GABAergic synapse_Homo sapiens_hsa047273.95549820
4Synaptic vesicle cycle_Homo sapiens_hsa047213.85848345
5Morphine addiction_Homo sapiens_hsa050323.36669457
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.15106563
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.71437047
8Circadian rhythm_Homo sapiens_hsa047102.60796734
9Fructose and mannose metabolism_Homo sapiens_hsa000512.50938615
10Circadian entrainment_Homo sapiens_hsa047132.39220200
11Insulin secretion_Homo sapiens_hsa049112.16244885
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.13035627
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.12244347
14Olfactory transduction_Homo sapiens_hsa047402.10975379
15Renin secretion_Homo sapiens_hsa049242.02355015
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.88785007
17Salivary secretion_Homo sapiens_hsa049701.72415348
18Cholinergic synapse_Homo sapiens_hsa047251.72367483
19Biosynthesis of amino acids_Homo sapiens_hsa012301.71220956
20Cardiac muscle contraction_Homo sapiens_hsa042601.68055715
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67452887
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.61684551
23Glutamatergic synapse_Homo sapiens_hsa047241.61318396
24Pentose phosphate pathway_Homo sapiens_hsa000301.59866539
25Oxytocin signaling pathway_Homo sapiens_hsa049211.58676212
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56404945
27Serotonergic synapse_Homo sapiens_hsa047261.52352156
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44666398
29Dilated cardiomyopathy_Homo sapiens_hsa054141.36042952
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.30528541
31Galactose metabolism_Homo sapiens_hsa000521.29595642
32Dopaminergic synapse_Homo sapiens_hsa047281.27721737
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26258721
34Collecting duct acid secretion_Homo sapiens_hsa049661.24243639
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23620064
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22652050
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.21091672
38Mineral absorption_Homo sapiens_hsa049781.09781156
39Taste transduction_Homo sapiens_hsa047421.09159066
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07560527
41Calcium signaling pathway_Homo sapiens_hsa040201.05856508
42Type II diabetes mellitus_Homo sapiens_hsa049301.03449882
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00030161
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.86423643
45Gap junction_Homo sapiens_hsa045400.84479693
46cAMP signaling pathway_Homo sapiens_hsa040240.83894820
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76801767
48Carbon metabolism_Homo sapiens_hsa012000.76072874
49HIF-1 signaling pathway_Homo sapiens_hsa040660.75591954
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73623159
51mTOR signaling pathway_Homo sapiens_hsa041500.73040963
52Inositol phosphate metabolism_Homo sapiens_hsa005620.71093675
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64731752
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58465141
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57253478
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56421855
57ABC transporters_Homo sapiens_hsa020100.51297339
58Cocaine addiction_Homo sapiens_hsa050300.51156323
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49593730
60Alcoholism_Homo sapiens_hsa050340.48227370
61GnRH signaling pathway_Homo sapiens_hsa049120.47940703
62Regulation of autophagy_Homo sapiens_hsa041400.45874979
63Pancreatic secretion_Homo sapiens_hsa049720.45626436
64Long-term depression_Homo sapiens_hsa047300.44384367
65AMPK signaling pathway_Homo sapiens_hsa041520.43945605
66Bile secretion_Homo sapiens_hsa049760.43241017
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.41120757
68Renal cell carcinoma_Homo sapiens_hsa052110.39318364
69Amphetamine addiction_Homo sapiens_hsa050310.38388481
70MAPK signaling pathway_Homo sapiens_hsa040100.36324606
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35591190
72Vibrio cholerae infection_Homo sapiens_hsa051100.35568158
73Gastric acid secretion_Homo sapiens_hsa049710.35056527
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34944948
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33204640
76Glucagon signaling pathway_Homo sapiens_hsa049220.33045476
77Pyruvate metabolism_Homo sapiens_hsa006200.31484933
78Choline metabolism in cancer_Homo sapiens_hsa052310.29185292
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.23140448
80Purine metabolism_Homo sapiens_hsa002300.22786950
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21420728
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21194501
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20643929
84Retinol metabolism_Homo sapiens_hsa008300.19963547
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.19053913
86Colorectal cancer_Homo sapiens_hsa052100.17597490
87Endometrial cancer_Homo sapiens_hsa052130.16380588
88Rheumatoid arthritis_Homo sapiens_hsa053230.15157975
89Endocytosis_Homo sapiens_hsa041440.14016884
90Protein digestion and absorption_Homo sapiens_hsa049740.13396952
91Arginine biosynthesis_Homo sapiens_hsa002200.11965774
92Lysine degradation_Homo sapiens_hsa003100.11487073
93Lysosome_Homo sapiens_hsa041420.11467434
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.10295572
95Glycerolipid metabolism_Homo sapiens_hsa005610.10274783
96Starch and sucrose metabolism_Homo sapiens_hsa005000.09945456
97Ras signaling pathway_Homo sapiens_hsa040140.09704879
98Thyroid hormone synthesis_Homo sapiens_hsa049180.07628730
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.07081806
100Axon guidance_Homo sapiens_hsa043600.06732176

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