LAD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.87434830
2hemidesmosome assembly (GO:0031581)7.13772389
3proline biosynthetic process (GO:0006561)6.95012482
4bundle of His cell to Purkinje myocyte communication (GO:0086069)6.12612824
5proline metabolic process (GO:0006560)5.79971964
6interferon-gamma secretion (GO:0072643)5.64644475
7hair cycle (GO:0042633)5.39256021
8molting cycle (GO:0042303)5.39256021
9regulation of water loss via skin (GO:0033561)5.38673604
10keratinization (GO:0031424)5.22371812
11regulation of integrin activation (GO:0033623)5.14536607
12establishment of skin barrier (GO:0061436)5.02615330
13embryonic process involved in female pregnancy (GO:0060136)4.70283179
14intestinal epithelial cell development (GO:0060576)4.66416571
15gap junction assembly (GO:0016264)4.58053134
16citrulline biosynthetic process (GO:0019240)4.56948122
17positive regulation of protein homooligomerization (GO:0032464)4.33449571
18establishment of apical/basal cell polarity (GO:0035089)4.29347207
19surfactant homeostasis (GO:0043129)4.21325776
20keratinocyte proliferation (GO:0043616)4.18329269
21regulation of keratinocyte proliferation (GO:0010837)4.08944092
22trophectodermal cell differentiation (GO:0001829)4.07255823
23keratinocyte differentiation (GO:0030216)4.01306848
24positive regulation of keratinocyte differentiation (GO:0045618)3.94252638
25regulation of keratinocyte differentiation (GO:0045616)3.92670205
26hypotonic response (GO:0006971)3.87252472
27intestinal cholesterol absorption (GO:0030299)3.82743834
28intestinal absorption (GO:0050892)3.79828172
29multicellular organismal water homeostasis (GO:0050891)3.70996454
30regulation of protein homooligomerization (GO:0032462)3.70630563
31transcription from mitochondrial promoter (GO:0006390)3.67091808
32intermediate filament organization (GO:0045109)3.67082020
33oocyte development (GO:0048599)3.61311202
34citrulline metabolic process (GO:0000052)3.57635191
35regulation of podosome assembly (GO:0071801)3.55085511
36regulation of chemokine secretion (GO:0090196)3.54464473
37epithelial cell differentiation involved in prostate gland development (GO:0060742)3.54265112
38chemical homeostasis within a tissue (GO:0048875)3.46435292
39establishment of monopolar cell polarity (GO:0061162)3.44484496
40establishment or maintenance of monopolar cell polarity (GO:0061339)3.44484496
41epidermal cell differentiation (GO:0009913)3.36801743
42positive regulation of protein oligomerization (GO:0032461)3.35413368
43negative regulation of keratinocyte proliferation (GO:0010839)3.34855648
44embryonic camera-type eye development (GO:0031076)3.32564545
45hepatocyte apoptotic process (GO:0097284)3.32188199
46NIK/NF-kappaB signaling (GO:0038061)3.30227316
47phospholipid scrambling (GO:0017121)3.27284402
48activation of Rac GTPase activity (GO:0032863)3.27043994
49virion attachment to host cell (GO:0019062)3.24158622
50adhesion of symbiont to host cell (GO:0044650)3.24158622
51COPI coating of Golgi vesicle (GO:0048205)3.23402865
52Golgi transport vesicle coating (GO:0048200)3.23402865
53protein kinase C signaling (GO:0070528)3.23385212
54regulation of cholesterol homeostasis (GO:2000188)3.22896959
55face development (GO:0060324)3.21254517
56regulation of hippo signaling (GO:0035330)3.19449265
57renal absorption (GO:0070293)3.19302892
58NADH metabolic process (GO:0006734)3.18108587
59regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.17788291
60urea cycle (GO:0000050)3.16074652
61polarized epithelial cell differentiation (GO:0030859)3.16055539
62apoptotic process involved in morphogenesis (GO:0060561)3.13287533
63sulfur amino acid catabolic process (GO:0000098)3.12444008
64negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.08045097
65water homeostasis (GO:0030104)3.06560733
66GDP-mannose metabolic process (GO:0019673)3.05904164
67atrioventricular valve morphogenesis (GO:0003181)3.05186600
68keratinocyte development (GO:0003334)3.04073004
69epithelial cell-cell adhesion (GO:0090136)3.01863231
70establishment of tissue polarity (GO:0007164)3.00928485
71establishment of planar polarity (GO:0001736)3.00928485
72negative regulation of Ras GTPase activity (GO:0034261)2.98535635
73renal system process involved in regulation of blood volume (GO:0001977)2.97644296
74urea metabolic process (GO:0019627)2.97248687
75negative regulation of glial cell proliferation (GO:0060253)2.91723053
76epidermis development (GO:0008544)2.90611651
77regulation of glomerular filtration (GO:0003093)2.88869662
78regulation of acrosome reaction (GO:0060046)2.87474109
79peptide cross-linking (GO:0018149)2.87123341
80ectoderm development (GO:0007398)2.86957844
81positive regulation of epidermal cell differentiation (GO:0045606)2.85202723
82negative regulation of epidermis development (GO:0045683)2.85074113
83glutamine family amino acid biosynthetic process (GO:0009084)2.83800407
84regulation of protein oligomerization (GO:0032459)2.81869184
85cellular glucuronidation (GO:0052695)2.80725830
86positive regulation of Cdc42 GTPase activity (GO:0043089)2.78632500
87diol metabolic process (GO:0034311)2.78169760
88intermediate filament cytoskeleton organization (GO:0045104)2.76854015
89protein localization to endosome (GO:0036010)2.76206139
90calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.76130241
91negative regulation of fatty acid biosynthetic process (GO:0045717)2.73786107
92regulation of cardioblast differentiation (GO:0051890)2.73618702
93cell differentiation involved in embryonic placenta development (GO:0060706)2.73501230
94planar cell polarity pathway involved in neural tube closure (GO:0090179)2.72681155
95positive regulation of epidermis development (GO:0045684)2.71910519
96branching involved in mammary gland duct morphogenesis (GO:0060444)2.71831793
97negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.71620752
98glutathione biosynthetic process (GO:0006750)2.69493001
99cell-cell junction assembly (GO:0007043)2.68941561
100cell-substrate junction assembly (GO:0007044)2.67618513
101glucuronate metabolic process (GO:0019585)2.66717766
102uronic acid metabolic process (GO:0006063)2.66717766
103tight junction assembly (GO:0070830)2.66295325
104cytoskeletal anchoring at plasma membrane (GO:0007016)2.66245551
105phosphatidylserine acyl-chain remodeling (GO:0036150)2.65314565
106sulfate transmembrane transport (GO:1902358)2.65101843
107skin morphogenesis (GO:0043589)2.64283035
108replication fork processing (GO:0031297)2.63510978
109dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.63192700
110primary alcohol catabolic process (GO:0034310)2.63140638
111columnar/cuboidal epithelial cell development (GO:0002066)2.62263584
112intermediate filament-based process (GO:0045103)2.62079435
113positive regulation of pseudopodium assembly (GO:0031274)2.62078428
114renal filtration (GO:0097205)2.61980064
115regulation of Cdc42 GTPase activity (GO:0043088)2.59914698
116nonribosomal peptide biosynthetic process (GO:0019184)2.59644959
117regulation of epidermis development (GO:0045682)2.58956266
118regulation of apoptotic process involved in morphogenesis (GO:1902337)2.58952277
119negative regulation of protein oligomerization (GO:0032460)2.58613838
120regulation of hair follicle development (GO:0051797)2.58363271
121phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.58362345
122flavonoid metabolic process (GO:0009812)2.58295857
123sphingosine metabolic process (GO:0006670)2.57328475
124angiotensin maturation (GO:0002003)2.57323898
125regulation of translational fidelity (GO:0006450)2.56753205
126nucleotide-sugar biosynthetic process (GO:0009226)2.55926300
127cellular response to vitamin D (GO:0071305)2.55914583
128sphingoid metabolic process (GO:0046519)2.55068911
129nitrogen cycle metabolic process (GO:0071941)2.54924211
130regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.52896676
131regulation of viral release from host cell (GO:1902186)2.52819161
132cellular response to lithium ion (GO:0071285)2.51923233
133vitamin A metabolic process (GO:0006776)2.51508274
134antigen processing and presentation of endogenous antigen (GO:0019883)2.51273140
135negative regulation of cell fate specification (GO:0009996)2.51018067
136regulation of bile acid biosynthetic process (GO:0070857)2.50347533
137embryonic placenta development (GO:0001892)2.49365844
138regulation of transforming growth factor beta2 production (GO:0032909)2.49040310
139regulation of cholesterol biosynthetic process (GO:0045540)2.48851090
140regulation of pseudopodium assembly (GO:0031272)2.48398095
141endosome organization (GO:0007032)2.47634813
142tumor necrosis factor-mediated signaling pathway (GO:0033209)2.47394116
143regulation of vitamin metabolic process (GO:0030656)2.47359334
144receptor catabolic process (GO:0032801)2.46962432
145signal complex assembly (GO:0007172)2.46367187
146bone morphogenesis (GO:0060349)2.46244049
147mitotic G1 DNA damage checkpoint (GO:0031571)2.45774462
148ventricular cardiac muscle cell action potential (GO:0086005)2.45673478
149regulation of endothelial cell chemotaxis (GO:2001026)2.44312884
150amyloid precursor protein metabolic process (GO:0042982)2.44208650
151adhesion of symbiont to host (GO:0044406)2.43645562
152epoxygenase P450 pathway (GO:0019373)2.43573269
153cell-substrate adherens junction assembly (GO:0007045)2.43546676
154focal adhesion assembly (GO:0048041)2.43546676
155linoleic acid metabolic process (GO:0043651)2.41447230
156cell junction assembly (GO:0034329)2.40987040
157regulation of epidermal cell differentiation (GO:0045604)2.39137001
158cellular response to ATP (GO:0071318)2.39090241
159eyelid development in camera-type eye (GO:0061029)2.38736689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.98181011
2CDX2_20551321_ChIP-Seq_CACO-2_Human2.69513638
3ZNF263_19887448_ChIP-Seq_K562_Human2.63372795
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.24985507
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.23892815
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.20867951
7* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.17305201
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.11107444
9* RACK7_27058665_Chip-Seq_MCF-7_Human2.08307452
10TP63_17297297_ChIP-ChIP_HaCaT_Human11.6499126
11* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.99415315
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97721768
13* GATA6_25053715_ChIP-Seq_YYC3_Human1.93791691
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86187296
15* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.81503215
16TRIM28_21343339_ChIP-Seq_HEK293_Human1.81090750
17KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.80897225
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.74445658
19LXR_22292898_ChIP-Seq_THP-1_Human1.72927431
20* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.67494756
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.65905955
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.65905955
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.65905955
24* GATA4_25053715_ChIP-Seq_YYC3_Human1.62402598
25ATF3_27146783_Chip-Seq_COLON_Human1.61148097
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.61056976
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56920538
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.56258666
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56043004
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.55551002
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54756055
32* RUNX1_27514584_Chip-Seq_MCF-7_Human1.54502241
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54349880
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52636159
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52231674
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51318171
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.48987919
38SOX2_20726797_ChIP-Seq_SW620_Human1.47804035
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.45931593
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44845272
41TCF3_18692474_ChIP-Seq_MEFs_Mouse1.42540861
42* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.40547362
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38257119
44VDR_21846776_ChIP-Seq_THP-1_Human1.37281404
45ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36340708
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.35094789
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34599647
48SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32689867
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28527153
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27726462
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26263332
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24056527
53* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23495164
54* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23495164
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22213611
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.20692483
57KLF5_25053715_ChIP-Seq_YYC3_Human1.20430502
58NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20218779
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.19424471
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16655263
61TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16636389
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15644139
63* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.15169852
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14538138
65EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.13520613
66* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12256026
67SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.11715439
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10832221
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10503082
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08758418
71POU5F1_16518401_ChIP-PET_MESCs_Mouse1.05925815
72SMC4_20622854_ChIP-Seq_HELA_Human1.05182692
73* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04973925
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04035929
75LXR_22158963_ChIP-Seq_LIVER_Mouse1.04013626
76* TP63_22573176_ChIP-Seq_HFKS_Human1.03341771
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02869212
78NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99193150
79* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99192336
80NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99020614
81BCOR_27268052_Chip-Seq_Bcells_Human0.98076508
82STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97321566
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96382412
84NANOG_18692474_ChIP-Seq_MESCs_Mouse0.94951357
85SA1_27219007_Chip-Seq_ERYTHROID_Human0.94929608
86GATA3_24758297_ChIP-Seq_MCF-7_Human0.94224233
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93818900
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93699131
89ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93262896
90TET1_21451524_ChIP-Seq_MESCs_Mouse0.93085045
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92981628
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92658506
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91815650
94UBF1/2_26484160_Chip-Seq_HMECs_Human0.90831324
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90705505
96SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90168107
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89899209
98NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89674911
99CREB1_26743006_Chip-Seq_LNCaP_Human0.89281834
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89081770
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88829199
102CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88815597
103SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87871623
104FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87724037
105CLOCK_20551151_ChIP-Seq_293T_Human0.87380595
106OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87012278
107* CTCF_27219007_Chip-Seq_Bcells_Human0.86193044
108TCF7_22412390_ChIP-Seq_EML_Mouse0.86023001
109KDM2B_26808549_Chip-Seq_DND41_Human0.85646599
110P68_20966046_ChIP-Seq_HELA_Human0.85339690
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84473289
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84278719
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84156186
114KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83362375
115GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83007747
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82853376
117SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82785732
118CHD1_26751641_Chip-Seq_LNCaP_Human0.82753997
119KDM2B_26808549_Chip-Seq_K562_Human0.82733369
120MYC_19079543_ChIP-ChIP_MESCs_Mouse0.82216418
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82011388
122* TP63_23658742_ChIP-Seq_EP156T_Human0.81737916
123PHF8_20622854_ChIP-Seq_HELA_Human0.81278998
124* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79903431
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79620324
126ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.79392858
127JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.78818260
128SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.78631562
129AR_21909140_ChIP-Seq_LNCAP_Human0.77775450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.03297216
2MP0002254_reproductive_system_inflammat4.65704217
3MP0002796_impaired_skin_barrier4.65266422
4MP0000579_abnormal_nail_morphology3.35419847
5MP0003453_abnormal_keratinocyte_physiol3.29311762
6MP0005501_abnormal_skin_physiology3.02204916
7MP0004264_abnormal_extraembryonic_tissu2.76508678
8MP0010352_gastrointestinal_tract_polyps2.57267047
9MP0002098_abnormal_vibrissa_morphology2.51617806
10MP0003941_abnormal_skin_development2.46640980
11MP0002009_preneoplasia2.42653165
12MP0002060_abnormal_skin_morphology2.34988174
13MP0005409_darkened_coat_color2.34895164
14MP0001216_abnormal_epidermal_layer2.25692183
15MP0003705_abnormal_hypodermis_morpholog2.22651582
16MP0010678_abnormal_skin_adnexa2.22509179
17MP0001873_stomach_inflammation2.22267177
18MP0001346_abnormal_lacrimal_gland2.17054099
19MP0005275_abnormal_skin_tensile2.05627735
20MP0000467_abnormal_esophagus_morphology2.03645357
21MP0002138_abnormal_hepatobiliary_system1.95050684
22MP0000383_abnormal_hair_follicle1.91675514
23MP0010030_abnormal_orbit_morphology1.86692003
24MP0005360_urolithiasis1.83463014
25MP0004019_abnormal_vitamin_homeostasis1.83069344
26MP0001348_abnormal_lacrimal_gland1.82418713
27MP0000762_abnormal_tongue_morphology1.73087993
28MP0004782_abnormal_surfactant_physiolog1.71855937
29MP0000462_abnormal_digestive_system1.69732168
30MP0004947_skin_inflammation1.68554785
31MP0010155_abnormal_intestine_physiology1.68105072
32MP0010771_integument_phenotype1.67709676
33MP0003566_abnormal_cell_adhesion1.64805784
34MP0001666_abnormal_nutrient_absorption1.62157692
35MP0000377_abnormal_hair_follicle1.59832482
36MP0009840_abnormal_foam_cell1.55498310
37MP0008057_abnormal_DNA_replication1.53317664
38MP0005076_abnormal_cell_differentiation1.52047354
39MP0000537_abnormal_urethra_morphology1.50811780
40MP0001849_ear_inflammation1.49328807
41MP0000470_abnormal_stomach_morphology1.48980774
42MP0002166_altered_tumor_susceptibility1.48843044
43MP0000490_abnormal_crypts_of1.47810481
44MP0003191_abnormal_cellular_cholesterol1.47451773
45MP0000685_abnormal_immune_system1.44260846
46MP0009278_abnormal_bone_marrow1.43773982
47MP0003866_abnormal_defecation1.43508810
48MP0003300_gastrointestinal_ulcer1.38614788
49MP0005085_abnormal_gallbladder_physiolo1.37327446
50MP0008004_abnormal_stomach_pH1.33990443
51MP0009053_abnormal_anal_canal1.26969243
52MP0002006_tumorigenesis1.24335926
53MP0003315_abnormal_perineum_morphology1.21776566
54MP0000477_abnormal_intestine_morphology1.15705986
55MP0000538_abnormal_urinary_bladder1.12185408
56MP0009931_abnormal_skin_appearance1.11536427
57MP0004381_abnormal_hair_follicle1.10957067
58MP0000367_abnormal_coat/_hair1.09308912
59MP0005310_abnormal_salivary_gland1.08606192
60MP0000647_abnormal_sebaceous_gland1.06424818
61MP0000566_synostosis1.05178794
62MP0003718_maternal_effect1.05129430
63MP0002234_abnormal_pharynx_morphology1.04016796
64MP0009780_abnormal_chondrocyte_physiolo1.02997316
65MP0003183_abnormal_peptide_metabolism1.00074036
66MP0005381_digestive/alimentary_phenotyp0.98233324
67MP0000627_abnormal_mammary_gland0.97739152
68MP0004185_abnormal_adipocyte_glucose0.97737028
69MP0000613_abnormal_salivary_gland0.97346317
70MP0000427_abnormal_hair_cycle0.94465005
71MP0003283_abnormal_digestive_organ0.93460599
72MP0008260_abnormal_autophagy0.93356478
73MP0002089_abnormal_postnatal_growth/wei0.92422860
74MP0005023_abnormal_wound_healing0.91890664
75MP0003806_abnormal_nucleotide_metabolis0.91554841
76MP0000516_abnormal_urinary_system0.90869429
77MP0005367_renal/urinary_system_phenotyp0.90869429
78MP0001663_abnormal_digestive_system0.90475906
79MP0001191_abnormal_skin_condition0.89664972
80MP0009643_abnormal_urine_homeostasis0.87961339
81MP0004858_abnormal_nervous_system0.87931678
82MP0004272_abnormal_basement_membrane0.87375034
83MP0009379_abnormal_foot_pigmentation0.85793106
84MP0003045_fibrosis0.85631074
85MP0003119_abnormal_digestive_system0.84838594
86MP0003878_abnormal_ear_physiology0.83256126
87MP0005377_hearing/vestibular/ear_phenot0.83256126
88MP0002277_abnormal_respiratory_mucosa0.82731122
89MP0002282_abnormal_trachea_morphology0.79434251
90MP0003693_abnormal_embryo_hatching0.78214707
91MP0003763_abnormal_thymus_physiology0.78214386
92MP0002877_abnormal_melanocyte_morpholog0.77286586
93MP0001664_abnormal_digestion0.76105757
94MP0002136_abnormal_kidney_physiology0.75787925
95MP0004957_abnormal_blastocyst_morpholog0.75421241
96MP0000858_altered_metastatic_potential0.73989174
97MP0001340_abnormal_eyelid_morphology0.73732287
98MP0003252_abnormal_bile_duct0.73176325
99MP0001765_abnormal_ion_homeostasis0.72628516
100MP0002111_abnormal_tail_morphology0.67668696
101MP0000678_abnormal_parathyroid_gland0.67509792
102MP0002086_abnormal_extraembryonic_tissu0.65874348
103MP0005666_abnormal_adipose_tissue0.65871923
104MP0004043_abnormal_pH_regulation0.65488169
105MP0002249_abnormal_larynx_morphology0.65059995
106MP0003868_abnormal_feces_composition0.62768269
107MP0005365_abnormal_bile_salt0.62761654
108MP0005174_abnormal_tail_pigmentation0.62546408
109MP0005257_abnormal_intraocular_pressure0.62192856
110MP0008875_abnormal_xenobiotic_pharmacok0.62186978
111MP0003890_abnormal_embryonic-extraembry0.60107675
112MP0005248_abnormal_Harderian_gland0.59067272
113MP0001545_abnormal_hematopoietic_system0.58812052
114MP0005397_hematopoietic_system_phenotyp0.58812052
115MP0003936_abnormal_reproductive_system0.58119369
116MP0002139_abnormal_hepatobiliary_system0.57051189
117MP0001243_abnormal_dermal_layer0.56391192
118MP0006082_CNS_inflammation0.55954943
119MP0002405_respiratory_system_inflammati0.55674863
120MP0004233_abnormal_muscle_weight0.55417841
121MP0005451_abnormal_body_composition0.54497991
122MP0001881_abnormal_mammary_gland0.53744845
123MP0005083_abnormal_biliary_tract0.53350758
124MP0000465_gastrointestinal_hemorrhage0.52183197
125MP0001730_embryonic_growth_arrest0.49376204
126MP0005375_adipose_tissue_phenotype0.46172760
127MP0003638_abnormal_response/metabolism_0.44882557
128MP0002896_abnormal_bone_mineralization0.44465804
129MP0001851_eye_inflammation0.44116205
130MP0005395_other_phenotype0.43345877
131MP0005166_decreased_susceptibility_to0.40480657
132MP0005636_abnormal_mineral_homeostasis0.39932075

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.65007618
2Plantar hyperkeratosis (HP:0007556)5.61709436
3Pustule (HP:0200039)5.33392025
4Milia (HP:0001056)5.22182997
5Alopecia of scalp (HP:0002293)5.02359463
6Onycholysis (HP:0001806)4.93854815
7Hypotrichosis (HP:0001006)4.88487310
8Pili torti (HP:0003777)4.84915583
9Fragile nails (HP:0001808)4.80272621
10Woolly hair (HP:0002224)4.75521498
11Palmoplantar hyperkeratosis (HP:0000972)4.73408461
12Palmar hyperkeratosis (HP:0010765)4.41742366
13Nail dystrophy (HP:0008404)4.01908709
14Oral leukoplakia (HP:0002745)3.80155983
15Abnormal hemoglobin (HP:0011902)3.71411273
16Increased IgE level (HP:0003212)3.54488378
17Abnormality of the gastric mucosa (HP:0004295)3.40442014
18Abnormality of the salivary glands (HP:0010286)3.37742963
19Lip pit (HP:0100267)3.27855895
20Poikiloderma (HP:0001029)3.27524242
21Abnormal blistering of the skin (HP:0008066)3.24428952
22Ileus (HP:0002595)3.23331688
23Atrophic scars (HP:0001075)3.11238379
24Abnormality of nail color (HP:0100643)3.10485168
25Concave nail (HP:0001598)2.96518162
26Abnormality of the axillary hair (HP:0100134)2.95092702
27Abnormality of secondary sexual hair (HP:0009888)2.95092702
28Abnormal hair laboratory examination (HP:0003328)2.94771726
29Malnutrition (HP:0004395)2.89045973
30Amelogenesis imperfecta (HP:0000705)2.78311726
31Congenital ichthyosiform erythroderma (HP:0007431)2.78124046
32Absent eyelashes (HP:0000561)2.76285739
33Abnormality of chloride homeostasis (HP:0011422)2.75696546
34Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.64686375
35Hyperactive renin-angiotensin system (HP:0000841)2.63823029
36Selective tooth agenesis (HP:0001592)2.63086266
37Abnormality of glutamine family amino acid metabolism (HP:0010902)2.63057333
38Abnormality of monocarboxylic acid metabolism (HP:0010996)2.62299283
39Cheilitis (HP:0100825)2.55314668
40Increased IgM level (HP:0003496)2.54263131
41Popliteal pterygium (HP:0009756)2.52765423
42Curly hair (HP:0002212)2.49421560
43Dehydration (HP:0001944)2.48478033
44Septate vagina (HP:0001153)2.47187446
45Thick nail (HP:0001805)2.44436322
46Fragile skin (HP:0001030)2.40849315
47Abnormality of proline metabolism (HP:0010907)2.39627931
48Hydroxyprolinuria (HP:0003080)2.39627931
49Hypoplasia of dental enamel (HP:0006297)2.38436776
50Ventricular fibrillation (HP:0001663)2.35848678
51Aplasia cutis congenita (HP:0001057)2.35223061
52Amniotic constriction ring (HP:0009775)2.32274564
53Abnormality of placental membranes (HP:0011409)2.32274564
54Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.32182112
55Vertebral hypoplasia (HP:0008417)2.32182112
56Dry hair (HP:0011359)2.30535845
57Premature loss of primary teeth (HP:0006323)2.24590219
58Pterygium (HP:0001059)2.22855004
59Trismus (HP:0000211)2.22132654
60Metabolic alkalosis (HP:0200114)2.20740388
61Hypoplastic labia majora (HP:0000059)2.19839060
62Oligodontia (HP:0000677)2.17605145
63Ridged nail (HP:0001807)2.13971611
64Acanthosis nigricans (HP:0000956)2.13084692
65Parakeratosis (HP:0001036)2.11603189
66Male infertility (HP:0003251)2.10792462
67Tongue fasciculations (HP:0001308)2.10495022
68Rib fusion (HP:0000902)2.09399936
69Widely patent fontanelles and sutures (HP:0004492)2.08937780
70Distal lower limb muscle weakness (HP:0009053)2.08368888
71Ulnar bowing (HP:0003031)2.07843108
72Abnormality of the dental root (HP:0006486)2.05594753
73Taurodontia (HP:0000679)2.05594753
74Abnormality of permanent molar morphology (HP:0011071)2.05594753
75Anonychia (HP:0001798)2.05325790
76Corneal erosion (HP:0200020)2.05184126
77Hypercortisolism (HP:0001578)2.00762307
78Focal segmental glomerulosclerosis (HP:0000097)1.98937120
79Esophageal atresia (HP:0002032)1.97501095
80Ventricular tachycardia (HP:0004756)1.96606123
81Neonatal death (HP:0003811)1.96000243
82Abnormality of the labia majora (HP:0012881)1.95860488
83Abnormality of the neuromuscular junction (HP:0003398)1.95810483
84Fatigable weakness (HP:0003473)1.95810483
85Sparse eyelashes (HP:0000653)1.95231320
86Rectal prolapse (HP:0002035)1.94996897
87Short humerus (HP:0005792)1.94281844
88Turricephaly (HP:0000262)1.94014403
89Nasolacrimal duct obstruction (HP:0000579)1.91407334
90Abnormality of the distal phalanges of the toes (HP:0010182)1.91277705
91Ectropion (HP:0000656)1.89808003
92Muscle fibrillation (HP:0010546)1.89678246
93Palmoplantar keratoderma (HP:0000982)1.87534976
94Abnormality of molar (HP:0011077)1.86688006
95Abnormality of molar morphology (HP:0011070)1.86688006
96Unilateral renal agenesis (HP:0000122)1.86336325
97Villous atrophy (HP:0011473)1.86110634
98Abnormality of small intestinal villus morphology (HP:0011472)1.86110634
99Carious teeth (HP:0000670)1.85546051
100Abnormality of the aortic arch (HP:0012303)1.84687880
101Axonal loss (HP:0003447)1.84009078
102Hyperparathyroidism (HP:0000843)1.83864896
103Bilateral sensorineural hearing impairment (HP:0008619)1.83832436
104Esophageal varix (HP:0002040)1.83819668
105Vascular calcification (HP:0004934)1.82509087
106Gastrointestinal dysmotility (HP:0002579)1.82497807
107Exocrine pancreatic insufficiency (HP:0001738)1.81373633
108Ureteral stenosis (HP:0000071)1.79824314
109Aplasia/hypoplasia of the humerus (HP:0006507)1.79605582
110Abnormality of the dental pulp (HP:0006479)1.79053109
111Intrahepatic cholestasis (HP:0001406)1.77604456
112Absent hair (HP:0002298)1.77451611
113Ankyloglossia (HP:0010296)1.76241853
114Conjunctival hamartoma (HP:0100780)1.75854620
115Hyperhidrosis (HP:0000975)1.75645957
116Hypohidrosis (HP:0000966)1.75503551
117Advanced eruption of teeth (HP:0006288)1.73905711
118Erythema (HP:0010783)1.73320933
119Erythroderma (HP:0001019)1.72705098
120Annular pancreas (HP:0001734)1.72701596
121Squamous cell carcinoma (HP:0002860)1.71171398
122Gout (HP:0001997)1.70432934
123Sparse scalp hair (HP:0002209)1.69903517
124Glomerulosclerosis (HP:0000096)1.67782638
125Xerostomia (HP:0000217)1.65686841
126Flat acetabular roof (HP:0003180)1.65441317
127Hypergammaglobulinemia (HP:0010702)1.64561130
128Thin bony cortex (HP:0002753)1.63726260
129Abdominal distention (HP:0003270)1.63491260
130Multifactorial inheritance (HP:0001426)1.62580706
131Blepharitis (HP:0000498)1.62201207
132Premature skin wrinkling (HP:0100678)1.61730109
133Coronal craniosynostosis (HP:0004440)1.61404084
134Urinary glycosaminoglycan excretion (HP:0003541)1.61391506
135Mucopolysacchariduria (HP:0008155)1.61391506
136Progressive sensorineural hearing impairment (HP:0000408)1.60907155
137Natal tooth (HP:0000695)1.60289424
138Fat malabsorption (HP:0002630)1.59518107
139Abnormality of carpal bone ossification (HP:0006257)1.57295129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.44052595
2DDR23.45286066
3ICK3.44516304
4MAPK153.35465296
5MST43.28560297
6MAP3K112.99168546
7SIK12.98549337
8MST1R2.72520449
9MATK2.26501135
10PIM22.24546977
11SMG12.21153710
12MAP3K62.02827226
13DYRK1B1.99443638
14BMX1.89262324
15MAP3K91.84020641
16MAP3K31.83354543
17STK241.80943406
18MAP3K141.78989919
19WNK41.76087213
20TYRO31.75151668
21NME21.73893706
22ARAF1.69543765
23FGR1.64620184
24MAP2K21.61968499
25LMTK21.58464288
26EPHB11.58455379
27CSK1.54685733
28NME11.54188095
29RPS6KB21.53778505
30FER1.53178975
31TRPM71.51877944
32EEF2K1.45348928
33FRK1.40837194
34LATS11.39989402
35EPHB21.39567102
36PTK61.39363205
37CHUK1.37142260
38PDGFRA1.32423347
39STK101.29152104
40MAP3K121.28092963
41PKN21.27144611
42MAPKAPK31.26839748
43PTK21.25788794
44FGFR41.20986902
45CDK61.20524173
46RIPK11.18629487
47MAP3K21.05936465
48MAP3K101.04427777
49IKBKB1.04132163
50STK391.01865935
51GSK3A0.98712010
52PRKD20.98516843
53EPHA30.95956006
54CDK120.93262536
55LRRK20.91534721
56TGFBR10.91145237
57MET0.91086574
58PRKG20.87986636
59TAOK10.87393426
60PRKCI0.87274199
61PIM10.86972218
62TESK10.85847888
63YES10.85133455
64CDK70.83943761
65NEK60.82316628
66ERN10.82188563
67STK38L0.82075401
68RPS6KA10.80447667
69TRIB30.80336355
70CDC42BPA0.77850199
71MAPK110.72963027
72MAP3K130.72910450
73PIK3CA0.72662733
74TYK20.72330511
75OXSR10.71892185
76PRKAA20.68850343
77NTRK10.68121718
78JAK30.67982592
79PINK10.67192929
80TBK10.67069585
81PAK40.66257735
82AKT30.65025591
83STK30.64326988
84MAPKAPK20.63470917
85SCYL20.62851662
86DYRK30.62631260
87MAP2K60.61010940
88MAP3K80.60622037
89FGFR30.59972388
90MUSK0.57724445
91RPS6KL10.57462016
92RPS6KC10.57462016
93ILK0.57063274
94PRPF4B0.56316488
95MTOR0.56101646
96BRAF0.52559144
97RPS6KA60.50396170
98LATS20.49510869
99MAP3K70.48932584
100KSR20.48644004
101ERBB20.48467317
102EIF2AK10.47882933
103TESK20.47563660
104CDK90.45897332
105PDPK10.45831538
106AURKB0.43636297
107BCR0.42020544
108DAPK10.41541627
109MAP3K10.40895829
110DMPK0.39260844
111EGFR0.38725161
112PRKAA10.37959564
113IKBKE0.36831363
114TTN0.36496646
115RPS6KA40.35994662
116MELK0.35863796
117JAK20.34503783
118RPS6KA20.33902498
119NLK0.33279131
120MAP2K10.33085448
121SIK30.32862869
122PBK0.32528562
123FGFR10.31703480
124IRAK30.31252920
125PDGFRB0.31008399
126CAMK2G0.30347733
127ERBB30.30204205
128IRAK20.30013533
129ABL20.29403931
130HIPK20.29039648
131TTK0.28642445
132GRK60.28283009
133FLT30.28218385
134RET0.28127922
135PRKD30.25386028
136MYLK0.19400900
137IRAK10.19159742
138RPS6KB10.18606713
139CAMK1D0.16479736
140STK380.16432190

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.06917236
2Fatty acid biosynthesis_Homo sapiens_hsa000612.76586406
3Mineral absorption_Homo sapiens_hsa049782.37965650
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30491019
5Fat digestion and absorption_Homo sapiens_hsa049752.26961405
6Adherens junction_Homo sapiens_hsa045202.15863060
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.05288253
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.03847545
9Maturity onset diabetes of the young_Homo sapiens_hsa049501.94766084
10Tight junction_Homo sapiens_hsa045301.87224045
11Bladder cancer_Homo sapiens_hsa052191.85824690
12Histidine metabolism_Homo sapiens_hsa003401.83677709
13Sulfur metabolism_Homo sapiens_hsa009201.82417255
14Hippo signaling pathway_Homo sapiens_hsa043901.78879453
15Arginine and proline metabolism_Homo sapiens_hsa003301.78429602
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77616657
17Folate biosynthesis_Homo sapiens_hsa007901.72915677
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.68396560
19Glutathione metabolism_Homo sapiens_hsa004801.64126088
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62881055
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.58799991
22Small cell lung cancer_Homo sapiens_hsa052221.54726310
23Vitamin digestion and absorption_Homo sapiens_hsa049771.52547703
24Fructose and mannose metabolism_Homo sapiens_hsa000511.48832506
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.42365360
26Basal cell carcinoma_Homo sapiens_hsa052171.41923038
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36394902
28p53 signaling pathway_Homo sapiens_hsa041151.35633017
29Hedgehog signaling pathway_Homo sapiens_hsa043401.30893977
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30284337
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28966339
32Ribosome_Homo sapiens_hsa030101.27607658
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23947750
34Linoleic acid metabolism_Homo sapiens_hsa005911.20531577
35PPAR signaling pathway_Homo sapiens_hsa033201.17894762
36Pancreatic secretion_Homo sapiens_hsa049721.17579951
37Phenylalanine metabolism_Homo sapiens_hsa003601.15848668
38Notch signaling pathway_Homo sapiens_hsa043301.14512329
39Protein digestion and absorption_Homo sapiens_hsa049741.12264805
40Renin-angiotensin system_Homo sapiens_hsa046141.10457739
41Legionellosis_Homo sapiens_hsa051341.10379095
42Shigellosis_Homo sapiens_hsa051311.07819064
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07523802
44Arachidonic acid metabolism_Homo sapiens_hsa005901.07195531
45Ovarian steroidogenesis_Homo sapiens_hsa049131.06614980
46Tryptophan metabolism_Homo sapiens_hsa003801.05568844
47Galactose metabolism_Homo sapiens_hsa000521.01866606
48Base excision repair_Homo sapiens_hsa034101.00569110
49Tyrosine metabolism_Homo sapiens_hsa003500.99890800
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97616358
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.96981260
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96360460
53Caffeine metabolism_Homo sapiens_hsa002320.93202775
54Toxoplasmosis_Homo sapiens_hsa051450.92881729
55Thyroid cancer_Homo sapiens_hsa052160.92124718
56Sulfur relay system_Homo sapiens_hsa041220.91897523
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91017094
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.90669988
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90117723
60VEGF signaling pathway_Homo sapiens_hsa043700.89388839
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.88771596
62Hepatitis C_Homo sapiens_hsa051600.87830738
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86837427
64Ether lipid metabolism_Homo sapiens_hsa005650.86429702
65Arginine biosynthesis_Homo sapiens_hsa002200.86150654
66Other glycan degradation_Homo sapiens_hsa005110.82268396
67Bile secretion_Homo sapiens_hsa049760.82043751
68TGF-beta signaling pathway_Homo sapiens_hsa043500.81839434
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81523694
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80607648
71Proteoglycans in cancer_Homo sapiens_hsa052050.80585674
72MicroRNAs in cancer_Homo sapiens_hsa052060.79589029
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79366938
74Acute myeloid leukemia_Homo sapiens_hsa052210.77996817
75Starch and sucrose metabolism_Homo sapiens_hsa005000.77969557
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77290326
77Lysine degradation_Homo sapiens_hsa003100.75878498
78Biosynthesis of amino acids_Homo sapiens_hsa012300.74099313
79Fatty acid metabolism_Homo sapiens_hsa012120.73819822
80Insulin signaling pathway_Homo sapiens_hsa049100.73473732
81Primary immunodeficiency_Homo sapiens_hsa053400.72639598
82Apoptosis_Homo sapiens_hsa042100.71496342
83Steroid biosynthesis_Homo sapiens_hsa001000.70498730
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.70309861
85Carbon metabolism_Homo sapiens_hsa012000.69891533
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69474714
87TNF signaling pathway_Homo sapiens_hsa046680.68968737
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68388017
89Fatty acid elongation_Homo sapiens_hsa000620.67574664
90Mismatch repair_Homo sapiens_hsa034300.67247392
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.65737750
92Vibrio cholerae infection_Homo sapiens_hsa051100.63511855
93Viral myocarditis_Homo sapiens_hsa054160.63240655
94beta-Alanine metabolism_Homo sapiens_hsa004100.63137332
95ECM-receptor interaction_Homo sapiens_hsa045120.62544485
96Fatty acid degradation_Homo sapiens_hsa000710.62311433
97Insulin resistance_Homo sapiens_hsa049310.62221385
98Chemical carcinogenesis_Homo sapiens_hsa052040.61924406
99Chronic myeloid leukemia_Homo sapiens_hsa052200.61597601
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60241504
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60121365
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60086909
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58299433
104Pyruvate metabolism_Homo sapiens_hsa006200.58103516
105Salmonella infection_Homo sapiens_hsa051320.57945586
106ErbB signaling pathway_Homo sapiens_hsa040120.57497625
107Retinol metabolism_Homo sapiens_hsa008300.54755831
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53383446
109Inositol phosphate metabolism_Homo sapiens_hsa005620.51092168
110Glycerolipid metabolism_Homo sapiens_hsa005610.50643265
111GnRH signaling pathway_Homo sapiens_hsa049120.50153068
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49916534
113Leishmaniasis_Homo sapiens_hsa051400.49551158
114Antigen processing and presentation_Homo sapiens_hsa046120.49344201
115Amoebiasis_Homo sapiens_hsa051460.49283782
116Sphingolipid metabolism_Homo sapiens_hsa006000.48659169
117Wnt signaling pathway_Homo sapiens_hsa043100.47710159
118Prion diseases_Homo sapiens_hsa050200.47542843
119Endometrial cancer_Homo sapiens_hsa052130.45984238
120Complement and coagulation cascades_Homo sapiens_hsa046100.45649824
121mTOR signaling pathway_Homo sapiens_hsa041500.44534470
122Influenza A_Homo sapiens_hsa051640.43582443
123AMPK signaling pathway_Homo sapiens_hsa041520.43130448
124Vitamin B6 metabolism_Homo sapiens_hsa007500.42962346
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41601070
126Focal adhesion_Homo sapiens_hsa045100.41594304
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40137983
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39734461
129Herpes simplex infection_Homo sapiens_hsa051680.39298390
130Endocytosis_Homo sapiens_hsa041440.38564622
131Prolactin signaling pathway_Homo sapiens_hsa049170.38238092
132Circadian rhythm_Homo sapiens_hsa047100.37641522
133N-Glycan biosynthesis_Homo sapiens_hsa005100.37632850
134Pentose phosphate pathway_Homo sapiens_hsa000300.37306041
135Glucagon signaling pathway_Homo sapiens_hsa049220.34285777
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.30067545

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