LAG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)8.28001330
2cytidine catabolic process (GO:0006216)8.28001330
3cytidine deamination (GO:0009972)8.28001330
4pyrimidine ribonucleoside catabolic process (GO:0046133)7.55477442
5DNA deamination (GO:0045006)6.96326763
6daunorubicin metabolic process (GO:0044597)6.66170788
7polyketide metabolic process (GO:0030638)6.66170788
8doxorubicin metabolic process (GO:0044598)6.66170788
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.30648127
10regulation of lymphocyte chemotaxis (GO:1901623)6.28457186
11positive regulation of chemokine secretion (GO:0090197)6.20878744
12regulation of chronic inflammatory response (GO:0002676)5.70322006
13negative regulation by host of viral transcription (GO:0043922)5.65007381
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.51398888
15regulation of chemokine secretion (GO:0090196)5.47948972
16interferon-gamma production (GO:0032609)5.23426189
17positive regulation of lymphocyte migration (GO:2000403)5.01762549
18regulation of T cell chemotaxis (GO:0010819)4.96038674
19positive regulation of T cell chemotaxis (GO:0010820)4.96038674
20eosinophil chemotaxis (GO:0048245)4.92947822
21regulation of regulatory T cell differentiation (GO:0045589)4.92198142
22regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.90747626
23G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.87907544
24regulation of B cell receptor signaling pathway (GO:0050855)4.66170674
25microglial cell activation (GO:0001774)4.65958906
26positive regulation of gamma-delta T cell activation (GO:0046645)4.58857926
27positive regulation of calcium-mediated signaling (GO:0050850)4.51377146
28negative regulation of viral genome replication (GO:0045071)4.41633397
29eosinophil migration (GO:0072677)4.41352681
30negative regulation of granulocyte differentiation (GO:0030853)4.34594403
31* positive regulation of natural killer cell mediated immunity (GO:0002717)4.19154156
32lymphocyte chemotaxis (GO:0048247)4.14841598
33positive regulation of tolerance induction (GO:0002645)4.12881753
34* positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.09149805
35* positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.08871054
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.08753714
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.08753714
38regulation of lymphocyte migration (GO:2000401)4.06961103
39* regulation of natural killer cell mediated immunity (GO:0002715)4.02237470
40* regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.02237470
41NIK/NF-kappaB signaling (GO:0038061)4.00410169
42aminoglycoside antibiotic metabolic process (GO:0030647)3.99115424
43negative thymic T cell selection (GO:0045060)3.92917326
44negative T cell selection (GO:0043383)3.90983620
45* positive regulation of cell killing (GO:0031343)3.88632559
46regulation of tolerance induction (GO:0002643)3.86063601
47positive regulation of T cell mediated cytotoxicity (GO:0001916)3.85196974
48regulation of interferon-beta biosynthetic process (GO:0045357)3.84357222
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.79403692
50regulation of alpha-beta T cell proliferation (GO:0046640)3.79255575
51antigen processing and presentation of endogenous antigen (GO:0019883)3.78526821
52* regulation of leukocyte mediated cytotoxicity (GO:0001910)3.76649260
53regulation of T cell mediated cytotoxicity (GO:0001914)3.67412058
54CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.66626603
55regulation of activation of Janus kinase activity (GO:0010533)3.65616100
56negative regulation of cell killing (GO:0031342)3.61552466
57negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.61552466
58* regulation of cell killing (GO:0031341)3.61535292
59negative regulation of B cell proliferation (GO:0030889)3.60877395
60macrophage activation involved in immune response (GO:0002281)3.59369648
61positive regulation of B cell differentiation (GO:0045579)3.59219709
62regulation of isotype switching to IgG isotypes (GO:0048302)3.57219073
63cellular response to type I interferon (GO:0071357)3.56442136
64type I interferon signaling pathway (GO:0060337)3.56442136
65pyrimidine nucleoside catabolic process (GO:0046135)3.55539434
66response to type I interferon (GO:0034340)3.51362122
67positive regulation of defense response to virus by host (GO:0002230)3.50551427
68modulation by host of viral transcription (GO:0043921)3.50340893
69modulation by host of symbiont transcription (GO:0052472)3.50340893
70tolerance induction (GO:0002507)3.49650642
71positive regulation of alpha-beta T cell proliferation (GO:0046641)3.49603455
72regulation of B cell differentiation (GO:0045577)3.49600242
73regulation of T cell tolerance induction (GO:0002664)3.49510954
74positive regulation of T cell migration (GO:2000406)3.49341848
75negative regulation of interleukin-12 production (GO:0032695)3.48895490
76monocyte chemotaxis (GO:0002548)3.45340365
77positive regulation of interleukin-8 secretion (GO:2000484)3.45223429
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.44725488
79purinergic nucleotide receptor signaling pathway (GO:0035590)3.44046308
80negative regulation of bone resorption (GO:0045779)3.43774650
81negative regulation of viral transcription (GO:0032897)3.43714438
82positive regulation of T cell apoptotic process (GO:0070234)3.41352434
83activated T cell proliferation (GO:0050798)3.41050901
84regulation of gamma-delta T cell differentiation (GO:0045586)3.38648334
85positive regulation of antigen processing and presentation (GO:0002579)3.35661367
86negative regulation of T cell apoptotic process (GO:0070233)3.34436406
87macrophage chemotaxis (GO:0048246)3.33751468
88negative regulation of T cell mediated immunity (GO:0002710)3.33235218
89keratan sulfate catabolic process (GO:0042340)3.32571298
90* regulation of interleukin-2 biosynthetic process (GO:0045076)3.32280169
91modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.28021583
92positive regulation of humoral immune response (GO:0002922)3.27679711
93G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.27287241
94natural killer cell activation (GO:0030101)3.26832160
95negative regulation of viral process (GO:0048525)3.26822032
96response to interleukin-15 (GO:0070672)3.26813426
97immunoglobulin mediated immune response (GO:0016064)3.26810268
98regulation of mononuclear cell migration (GO:0071675)3.26268975
99T cell mediated immunity (GO:0002456)3.26034313
100lymphocyte migration (GO:0072676)3.25611571
101positive regulation by symbiont of host defense response (GO:0052509)3.24929204
102modulation by symbiont of host defense response (GO:0052031)3.24929204
103modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.24929204
104modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.24929204
105positive regulation by organism of defense response of other organism involved in symbiotic interact3.24929204
106modulation by symbiont of host immune response (GO:0052553)3.24929204
107positive thymic T cell selection (GO:0045059)3.22021475
108positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.22010097
109regulation of viral genome replication (GO:0045069)3.21468383
110regulation of calcium-mediated signaling (GO:0050848)3.21127437
111regulation of T cell migration (GO:2000404)3.20067417
112regulation of RIG-I signaling pathway (GO:0039535)3.19561545
113cellular defense response (GO:0006968)3.19136269
114regulation of gamma-delta T cell activation (GO:0046643)3.18314866
115positive regulation of isotype switching (GO:0045830)3.16201423
116regulation of monocyte differentiation (GO:0045655)3.15920862
117thymic T cell selection (GO:0045061)3.15817200
118negative regulation of phagocytosis (GO:0050765)3.14881365
119T cell selection (GO:0045058)3.13582356
120regulation of antigen processing and presentation (GO:0002577)3.07887123
121regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.04214714
122regulation of interferon-alpha production (GO:0032647)3.03924615
123T cell costimulation (GO:0031295)3.02022966
124response to muramyl dipeptide (GO:0032495)3.01959898
125cellular response to interleukin-15 (GO:0071350)3.01863193
126lymphocyte costimulation (GO:0031294)3.01265027
127oligosaccharide catabolic process (GO:0009313)3.01251099
128T cell migration (GO:0072678)3.01184763
129leukocyte aggregation (GO:0070486)2.97857788
130myeloid dendritic cell activation (GO:0001773)2.92702278
131negative regulation of tissue remodeling (GO:0034104)2.91643203
132natural killer cell differentiation (GO:0001779)2.91488939
133B cell receptor signaling pathway (GO:0050853)2.90797977
134adaptation of signaling pathway (GO:0023058)2.90042254
135antigen receptor-mediated signaling pathway (GO:0050851)2.88679092
136mature B cell differentiation (GO:0002335)2.88376911
137interferon-gamma-mediated signaling pathway (GO:0060333)2.86133133
138regulation of interleukin-12 biosynthetic process (GO:0045075)2.85601037
139positive T cell selection (GO:0043368)2.85437667
140regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.84972089
141regulation of B cell proliferation (GO:0030888)2.83007814
142positive regulation of interferon-alpha production (GO:0032727)2.82875017
143T cell receptor signaling pathway (GO:0050852)2.82058737
144dendritic cell differentiation (GO:0097028)2.81856845
145mast cell activation (GO:0045576)2.81697729
146regulation of MHC class I biosynthetic process (GO:0045343)2.81305292
147hyaluronan catabolic process (GO:0030214)2.80280842
148positive regulation of interleukin-2 production (GO:0032743)2.80144516
149glycosphingolipid catabolic process (GO:0046479)2.80068061
150regulation of granulocyte differentiation (GO:0030852)2.78326571
151maintenance of protein location in nucleus (GO:0051457)2.78183775
152macrophage activation (GO:0042116)2.77793460
153negative regulation of interleukin-6 production (GO:0032715)2.76450084
154myeloid dendritic cell differentiation (GO:0043011)2.76163374
155purinergic receptor signaling pathway (GO:0035587)2.73767348
156cellular response to interferon-beta (GO:0035458)2.73683150
157positive regulation of DNA recombination (GO:0045911)2.72805324
158monocyte differentiation (GO:0030224)2.72772600
159positive regulation of immunoglobulin production (GO:0002639)2.67650521
160megakaryocyte development (GO:0035855)2.67452340
161negative regulation of bone remodeling (GO:0046851)2.67198408

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.60668964
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.98824692
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.47129996
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.18135927
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.13249615
6SCL_19346495_ChIP-Seq_HPC-7_Human3.69406883
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.62461780
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.51377060
9NOTCH1_21737748_ChIP-Seq_TLL_Human3.35443742
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.23126872
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.23126872
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.23126872
13IRF8_27001747_Chip-Seq_BMDM_Mouse3.13944169
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.07682280
15E2F7_22180533_ChIP-Seq_HELA_Human2.96863658
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91059302
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.89415431
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88731611
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.83418013
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.77398916
21RUNX_20019798_ChIP-Seq_JUKART_Human2.71510735
22MYC_22102868_ChIP-Seq_BL_Human2.55461836
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.48831427
24* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.47845507
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47068374
26MYB_26560356_Chip-Seq_TH2_Human2.39876474
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.35055731
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31565528
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.23442635
30SPI1_23547873_ChIP-Seq_NB4_Human2.22565779
31TP63_19390658_ChIP-ChIP_HaCaT_Human2.20622882
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16371702
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.15608954
34MYB_26560356_Chip-Seq_TH1_Human2.14348393
35MAF_26560356_Chip-Seq_TH1_Human2.05298300
36SPI1_23127762_ChIP-Seq_K562_Human1.97170201
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95457214
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94924302
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89992151
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.88504401
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87075070
42VDR_21846776_ChIP-Seq_THP-1_Human1.85414325
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.82605641
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73111944
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.72136271
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66196240
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60428933
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59595252
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58538177
50UTX_26944678_Chip-Seq_JUKART_Human1.53114131
51IRF1_19129219_ChIP-ChIP_H3396_Human1.51074672
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49787940
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47119207
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46558602
55VDR_23849224_ChIP-Seq_CD4+_Human1.45001865
56GATA3_27048872_Chip-Seq_THYMUS_Human1.44753837
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41736548
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41309481
59VDR_24763502_ChIP-Seq_THP-1_Human1.40248137
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.34717594
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31734437
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29802673
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.29788263
64* MAF_26560356_Chip-Seq_TH2_Human1.24668613
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22633781
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20879472
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20308571
68FOXP3_21729870_ChIP-Seq_TREG_Human1.19858728
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16966834
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14323930
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13281025
72GATA3_26560356_Chip-Seq_TH2_Human1.10531290
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09631016
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08158507
75PU_27001747_Chip-Seq_BMDM_Mouse1.04564835
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03604297
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03504983
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02523087
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02227996
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00967021
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98291163
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96797628
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96458604
84BCL6_27268052_Chip-Seq_Bcells_Human0.96316301
85EST1_17652178_ChIP-ChIP_JURKAT_Human0.95787173
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92808493
87CDX2_20551321_ChIP-Seq_CACO-2_Human0.91348639
88GATA1_22025678_ChIP-Seq_K562_Human0.87838043
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86881961
90VDR_24787735_ChIP-Seq_THP-1_Human0.86386066
91* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85636156
92CIITA_25753668_ChIP-Seq_RAJI_Human0.84078391
93GATA1_19941827_ChIP-Seq_MEL_Mouse0.83709099
94KDM2B_26808549_Chip-Seq_DND41_Human0.82862802
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.82060832
96* ELF1_20517297_ChIP-Seq_JURKAT_Human0.81270823
97KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.78958756
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.78779178
99SMAD_19615063_ChIP-ChIP_OVARY_Human0.78760452
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78745227
101P300_27268052_Chip-Seq_Bcells_Human0.77608727
102* BCOR_27268052_Chip-Seq_Bcells_Human0.77387141
103* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77121107
104NCOR1_26117541_ChIP-Seq_K562_Human0.76846490
105FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76541174
106GATA3_26560356_Chip-Seq_TH1_Human0.76519101
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75951324
108* SA1_27219007_Chip-Seq_Bcells_Human0.75625273
109EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.75579667
110ETS1_20019798_ChIP-Seq_JURKAT_Human0.74991211
111* ELK3_25401928_ChIP-Seq_HUVEC_Human0.74323806
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74213283
113NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.73998697
114STAT6_21828071_ChIP-Seq_BEAS2B_Human0.73634891
115RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.73279193
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71975622
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.70644209
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.69901077
119VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.69327414
120* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68189176
121TAF2_19829295_ChIP-Seq_ESCs_Human0.67727604
122* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.67483041
123E2F4_17652178_ChIP-ChIP_JURKAT_Human0.67039421
124ERG_20887958_ChIP-Seq_HPC-7_Mouse0.65866265
125* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.65774932
126PCGF2_27294783_Chip-Seq_NPCs_Mouse0.65487867
127SRF_21415370_ChIP-Seq_HL-1_Mouse0.65051490
128RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.64993337
129LXR_22292898_ChIP-Seq_THP-1_Human0.64894270
130FLI1_27457419_Chip-Seq_LIVER_Mouse0.64757513
131SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.64641925
132SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.64298587
133GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64008678
134CTCF_26484167_Chip-Seq_Bcells_Mouse0.63148242
135YY1_22570637_ChIP-Seq_MALME-3M_Human0.62948610
136TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.62931744
137SPI1_20517297_ChIP-Seq_HL60_Human0.62042620
138SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.59781328
139* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.57956352

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation4.95024584
2MP0005671_abnormal_response_to4.94715404
3MP0001835_abnormal_antigen_presentation4.21406793
4MP0002396_abnormal_hematopoietic_system2.93010896
5MP0001800_abnormal_humoral_immune2.92189819
6MP0003763_abnormal_thymus_physiology2.86095072
7MP0005000_abnormal_immune_tolerance2.61649742
8MP0002723_abnormal_immune_serum2.59150728
9MP0002452_abnormal_antigen_presenting2.58787683
10MP0001790_abnormal_immune_system2.58213651
11MP0005387_immune_system_phenotype2.58213651
12MP0005075_abnormal_melanosome_morpholog2.50574917
13MP0003191_abnormal_cellular_cholesterol2.46837357
14* MP0001819_abnormal_immune_cell2.44054026
15* MP0002420_abnormal_adaptive_immunity2.42694516
16MP0002138_abnormal_hepatobiliary_system2.38337983
17MP0000685_abnormal_immune_system2.36358510
18MP0009785_altered_susceptibility_to2.35542489
19MP0005025_abnormal_response_to2.33934814
20MP0003436_decreased_susceptibility_to2.27105526
21MP0002148_abnormal_hypersensitivity_rea2.21595240
22MP0002398_abnormal_bone_marrow2.20083539
23MP0009333_abnormal_splenocyte_physiolog2.19717685
24MP0006292_abnormal_olfactory_placode2.16669900
25MP0003172_abnormal_lysosome_physiology2.16056330
26* MP0000716_abnormal_immune_system2.04434015
27MP0002419_abnormal_innate_immunity2.02012321
28MP0002254_reproductive_system_inflammat1.98801336
29MP0002405_respiratory_system_inflammati1.97665979
30MP0005464_abnormal_platelet_physiology1.97445597
31MP0005310_abnormal_salivary_gland1.92025854
32* MP0000689_abnormal_spleen_morphology1.85443060
33MP0003303_peritoneal_inflammation1.79095379
34* MP0002722_abnormal_immune_system1.78246420
35* MP0002429_abnormal_blood_cell1.69149579
36MP0003183_abnormal_peptide_metabolism1.68836798
37MP0001873_stomach_inflammation1.66189120
38MP0003300_gastrointestinal_ulcer1.66092978
39MP0003724_increased_susceptibility_to1.65517365
40MP0010155_abnormal_intestine_physiology1.64917081
41MP0008007_abnormal_cellular_replicative1.62052857
42MP0000703_abnormal_thymus_morphology1.60494205
43MP0001853_heart_inflammation1.58709243
44MP0000490_abnormal_crypts_of1.57073575
45MP0001845_abnormal_inflammatory_respons1.50225655
46MP0002277_abnormal_respiratory_mucosa1.46770946
47MP0002933_joint_inflammation1.42337955
48MP0002877_abnormal_melanocyte_morpholog1.41724583
49MP0000569_abnormal_digit_pigmentation1.37606256
50MP0004264_abnormal_extraembryonic_tissu1.34846046
51MP0002163_abnormal_gland_morphology1.32619803
52MP0000343_altered_response_to1.26280113
53MP0002166_altered_tumor_susceptibility1.20091309
54MP0003075_altered_response_to1.18946256
55MP0000465_gastrointestinal_hemorrhage1.18277288
56MP0008469_abnormal_protein_level1.18024259
57MP0005058_abnormal_lysosome_morphology1.17851060
58MP0008004_abnormal_stomach_pH1.17001590
59MP0004510_myositis1.16488465
60MP0004782_abnormal_surfactant_physiolog1.15507118
61MP0004808_abnormal_hematopoietic_stem1.14852861
62MP0001533_abnormal_skeleton_physiology1.12837691
63MP0000858_altered_metastatic_potential1.11619996
64MP0002132_abnormal_respiratory_system1.11601770
65MP0008057_abnormal_DNA_replication1.10024707
66MP0002006_tumorigenesis1.07476268
67MP0002998_abnormal_bone_remodeling1.07392282
68MP0009763_increased_sensitivity_to1.05643930
69MP0005394_taste/olfaction_phenotype1.05168074
70MP0005499_abnormal_olfactory_system1.05168074
71MP0003448_altered_tumor_morphology1.02393408
72MP0001851_eye_inflammation1.01577811
73MP0003866_abnormal_defecation1.01478761
74MP0001545_abnormal_hematopoietic_system0.96986849
75MP0005397_hematopoietic_system_phenotyp0.96986849
76MP0005257_abnormal_intraocular_pressure0.95657343
77MP0004947_skin_inflammation0.95609674
78MP0003786_premature_aging0.94863010
79MP0008058_abnormal_DNA_repair0.92050999
80MP0000372_irregular_coat_pigmentation0.91387610
81MP0003045_fibrosis0.88496453
82MP0002928_abnormal_bile_duct0.88443048
83MP0003828_pulmonary_edema0.87751693
84MP0001663_abnormal_digestive_system0.87629406
85MP0004381_abnormal_hair_follicle0.87620978
86MP0002693_abnormal_pancreas_physiology0.87398155
87MP0009764_decreased_sensitivity_to0.84445891
88MP0005390_skeleton_phenotype0.80695871
89MP0003787_abnormal_imprinting0.79741527
90MP0005645_abnormal_hypothalamus_physiol0.76609740
91MP0003890_abnormal_embryonic-extraembry0.74003866
92MP0009765_abnormal_xenobiotic_induced0.71712108
93MP0001919_abnormal_reproductive_system0.70545545
94MP0004742_abnormal_vestibular_system0.69844420
95MP0003795_abnormal_bone_structure0.69554227
96MP0010307_abnormal_tumor_latency0.69097488
97MP0003011_delayed_dark_adaptation0.67903080
98MP0005166_decreased_susceptibility_to0.67489205
99MP0000313_abnormal_cell_death0.65439009
100MP0008873_increased_physiological_sensi0.64710109
101MP0005023_abnormal_wound_healing0.64492806
102MP0003122_maternal_imprinting0.63776259
103MP0001501_abnormal_sleep_pattern0.63402216
104MP0003077_abnormal_cell_cycle0.63270509
105MP0002019_abnormal_tumor_incidence0.63266617
106MP0001542_abnormal_bone_strength0.63172762
107MP0002136_abnormal_kidney_physiology0.62546626
108MP0000249_abnormal_blood_vessel0.61830526
109MP0003121_genomic_imprinting0.61533535
110MP0002332_abnormal_exercise_endurance0.60871895
111MP0010094_abnormal_chromosome_stability0.59649974
112MP0001881_abnormal_mammary_gland0.58802134
113MP0000371_diluted_coat_color0.57462913
114MP0005379_endocrine/exocrine_gland_phen0.57088138
115MP0005174_abnormal_tail_pigmentation0.56486528
116MP0003806_abnormal_nucleotide_metabolis0.54920576
117MP0001348_abnormal_lacrimal_gland0.54843273
118MP0004145_abnormal_muscle_electrophysio0.54030893
119MP0009643_abnormal_urine_homeostasis0.53113923
120MP0009840_abnormal_foam_cell0.52523305
121MP0005584_abnormal_enzyme/coenzyme_acti0.52224022
122MP0002095_abnormal_skin_pigmentation0.51381008
123MP0000767_abnormal_smooth_muscle0.50675528
124MP0000015_abnormal_ear_pigmentation0.50461899
125MP0000477_abnormal_intestine_morphology0.49288699
126MP0008961_abnormal_basal_metabolism0.48807965
127MP0000604_amyloidosis0.48485174
128MP0004883_abnormal_blood_vessel0.48087137
129MP0000920_abnormal_myelination0.47734580
130MP0001905_abnormal_dopamine_level0.46296014
131MP0005381_digestive/alimentary_phenotyp0.46274714
132MP0000609_abnormal_liver_physiology0.43629335
133MP0001727_abnormal_embryo_implantation0.41805790
134MP0005165_increased_susceptibility_to0.41463386
135MP0002083_premature_death0.38948184

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.64954727
2Abnormality of liposaccharide metabolism (HP:0010968)5.36991177
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.36991177
4Abnormality of glycolipid metabolism (HP:0010969)5.36991177
5Myositis (HP:0100614)4.93326673
6IgG deficiency (HP:0004315)4.62280737
7Glomerulonephritis (HP:0000099)4.44935785
8Autoimmune hemolytic anemia (HP:0001890)4.43779177
9Elevated erythrocyte sedimentation rate (HP:0003565)4.35822158
10Chronic diarrhea (HP:0002028)4.01355334
11Orchitis (HP:0100796)3.96433447
12Eczematoid dermatitis (HP:0000976)3.87780311
13Hypoproteinemia (HP:0003075)3.74271186
14Recurrent abscess formation (HP:0002722)3.69157433
15Aplastic anemia (HP:0001915)3.65812643
16IgM deficiency (HP:0002850)3.58375276
17Abnormality of macrophages (HP:0004311)3.38992884
18Intestinal fistula (HP:0100819)3.32234654
19Nasal polyposis (HP:0100582)3.30305024
20Retrobulbar optic neuritis (HP:0100654)3.29458446
21Optic neuritis (HP:0100653)3.29458446
22Recurrent bacterial skin infections (HP:0005406)3.28455963
23Rectovaginal fistula (HP:0000143)3.27438395
24Rectal fistula (HP:0100590)3.27438395
25Recurrent viral infections (HP:0004429)3.22038925
26Partial duplication of thumb phalanx (HP:0009944)3.20779096
27Joint swelling (HP:0001386)3.20076379
28Pustule (HP:0200039)3.17636171
29Gastrointestinal infarctions (HP:0005244)3.14258747
30Recurrent fungal infections (HP:0002841)3.07035387
31Cheilitis (HP:0100825)3.03836412
32Gangrene (HP:0100758)3.02054830
33Bilateral microphthalmos (HP:0007633)3.01677635
34Pulmonary infiltrates (HP:0002113)3.01032897
35Colitis (HP:0002583)2.98027405
36Inflammation of the large intestine (HP:0002037)2.96008893
37Panhypogammaglobulinemia (HP:0003139)2.91034660
38Complement deficiency (HP:0004431)2.89141526
39Chronic otitis media (HP:0000389)2.83646477
40Vasculitis (HP:0002633)2.83606691
41Thyroiditis (HP:0100646)2.82362000
42Abnormality of the nasal mucosa (HP:0000433)2.82090735
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.77064341
44Bronchitis (HP:0012387)2.76498054
45Orthostatic hypotension (HP:0001278)2.76260092
46Chronic mucocutaneous candidiasis (HP:0002728)2.73847809
47Recurrent cutaneous fungal infections (HP:0011370)2.73847809
48Gastrointestinal inflammation (HP:0004386)2.73806873
49Increased IgM level (HP:0003496)2.73388638
50Recurrent bronchitis (HP:0002837)2.73040221
51Vaginal fistula (HP:0004320)2.72356918
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.67177002
53Keratoconjunctivitis (HP:0001096)2.66059036
54Meningitis (HP:0001287)2.64643965
55Partial duplication of the phalanx of hand (HP:0009999)2.64146153
56T lymphocytopenia (HP:0005403)2.58904539
57Abnormality of T cells (HP:0002843)2.58613927
58Abnormality of T cell physiology (HP:0011840)2.56355243
59Hypoplasia of the thymus (HP:0000778)2.54835116
60Combined immunodeficiency (HP:0005387)2.54088109
61Recurrent skin infections (HP:0001581)2.51663429
62Pulmonary embolism (HP:0002204)2.50824941
63Lymphoma (HP:0002665)2.50509029
64Ureteral stenosis (HP:0000071)2.47460787
65Abnormality of T cell number (HP:0011839)2.47261406
66Hemoptysis (HP:0002105)2.44020454
67Increased neuronal autofluorescent lipopigment (HP:0002074)2.38170986
68Autoimmune thrombocytopenia (HP:0001973)2.34840283
69Skin rash (HP:0000988)2.34686578
70Chromsome breakage (HP:0040012)2.33405019
71Premature loss of primary teeth (HP:0006323)2.31247868
72Acute hepatic failure (HP:0006554)2.30565494
73Abnormality of the fovea (HP:0000493)2.27749375
74Arterial tortuosity (HP:0005116)2.26809950
75Chest pain (HP:0100749)2.25833783
76Agnosia (HP:0010524)2.24973937
77Ureteral obstruction (HP:0006000)2.23850092
783-Methylglutaconic aciduria (HP:0003535)2.22623248
79Chronic obstructive pulmonary disease (HP:0006510)2.22498253
80Obstructive lung disease (HP:0006536)2.22498253
81Hemiplegia (HP:0002301)2.19598723
82Eosinophilia (HP:0001880)2.19583188
83Abnormality of complement system (HP:0005339)2.18240357
84Abnormality of the pleura (HP:0002103)2.17575547
85Increased cerebral lipofuscin (HP:0011813)2.15727721
86Thrombocytosis (HP:0001894)2.15673798
87Leukocytosis (HP:0001974)2.15106939
88Encephalitis (HP:0002383)2.14961540
89Hypoalbuminemia (HP:0003073)2.14789258
90Abnormal albumin level (HP:0012116)2.14789258
91Recurrent otitis media (HP:0000403)2.14498033
92Pulmonary fibrosis (HP:0002206)2.13507692
93Urethral obstruction (HP:0000796)2.12921445
94Lymphopenia (HP:0001888)2.12781782
95Petechiae (HP:0000967)2.12163871
96Arterial thrombosis (HP:0004420)2.11251638
97Mutism (HP:0002300)2.10530809
98Abnormality of the prostate (HP:0008775)2.10365911
99Agammaglobulinemia (HP:0004432)2.10114581
100Keratitis (HP:0000491)2.08436114
101Glomerulopathy (HP:0100820)2.05682883
102Aplasia/Hypoplasia of the fovea (HP:0008060)2.05609852
103Hypoplasia of the fovea (HP:0007750)2.05609852
104Abnormality of eosinophils (HP:0001879)2.04507106
105Upper motor neuron abnormality (HP:0002127)2.03346487
106Abnormality of male internal genitalia (HP:0000022)2.03209910
107Gastrointestinal stroma tumor (HP:0100723)2.03098289
108Abnormality of the pericardium (HP:0001697)2.02873572
109Cellulitis (HP:0100658)2.01302856
110Duplication of thumb phalanx (HP:0009942)2.00875677
111Recurrent sinusitis (HP:0011108)2.00427583
112Mediastinal lymphadenopathy (HP:0100721)2.00112847
113B lymphocytopenia (HP:0010976)1.98432603
114Abnormality of B cell number (HP:0010975)1.98432603
115Hypergammaglobulinemia (HP:0010702)1.98231786
116Rib fusion (HP:0000902)1.98216276
117Abnormality of cells of the lymphoid lineage (HP:0012140)1.96730292
118IgA deficiency (HP:0002720)1.95815758
119Anorexia (HP:0002039)1.94772862
120Granulocytopenia (HP:0001913)1.92947297
121Hepatosplenomegaly (HP:0001433)1.91693528
122Prolonged bleeding time (HP:0003010)1.91492694
123Severe combined immunodeficiency (HP:0004430)1.90495720
124Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90398018
125Nephritis (HP:0000123)1.89302390
126Hypochromic microcytic anemia (HP:0004840)1.88732738
127Vascular tortuosity (HP:0004948)1.88634575
128Stomatitis (HP:0010280)1.88032385
129Epistaxis (HP:0000421)1.87405802
130Increased serum ferritin (HP:0003281)1.87108618
131Urticaria (HP:0001025)1.86589287
132Polyneuropathy (HP:0001271)1.85710291
133Hematochezia (HP:0002573)1.84005222
134Keratoconjunctivitis sicca (HP:0001097)1.82932374
135Gingivitis (HP:0000230)1.82597863
136Cerebral aneurysm (HP:0004944)1.82480460
137Basal ganglia calcification (HP:0002135)1.82131486
138Arthralgia (HP:0002829)1.81999014
139Progressive neurologic deterioration (HP:0002344)1.80559907
140Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78443638
141Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78443638
142Pancytopenia (HP:0001876)1.77686476
143Hypochromic anemia (HP:0001931)1.77531358
144Chronic sinusitis (HP:0011109)1.73364961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR25.54385623
2TXK4.15654612
3CSF1R4.12282211
4CDK123.43127570
5KDR3.05461364
6GRK73.04998822
7MAP4K12.98760071
8MAPK152.74013023
9ADRBK22.71167109
10ERN12.58969781
11GRK52.42025658
12MAP3K112.30227470
13TYK22.28248572
14STK102.18231964
15TSSK62.17628316
16MAPKAPK32.16974045
17MAP3K142.06195016
18JAK32.00889617
19GRK61.99705328
20ITK1.96217952
21ZAP701.92026955
22BLK1.79591006
23GRK11.66194901
24SIK31.62940693
25KIT1.59824870
26IRAK41.59613160
27TESK21.57769578
28MAPK71.55406796
29TLK11.54840258
30JAK11.49428152
31TBK11.47829729
32IKBKB1.47710257
33MATK1.47340242
34PAK41.44991963
35BCKDK1.43368431
36CLK11.35732456
37LCK1.28866921
38BUB11.25013023
39SIK21.24096002
40CSK1.23518841
41IKBKE1.22798041
42TAOK31.21747562
43TEC1.18004046
44SYK1.17910421
45HCK1.16161326
46FGFR31.14938555
47IRAK31.14484454
48TAOK11.13803713
49MST41.11091274
50RIPK41.06446989
51BTK1.01054306
52CAMK41.00211606
53MOS0.98683653
54VRK10.96450137
55CHUK0.86005726
56MAP3K120.85981140
57LYN0.85953768
58DAPK10.84409382
59EIF2AK20.82784099
60MAPK120.82491310
61VRK20.78875024
62FLT30.75963015
63EEF2K0.74845731
64WNK40.74783502
65TNK20.74362318
66MAP2K30.72733010
67SCYL20.71862085
68NME10.70392887
69WNK10.69900745
70HIPK20.68798294
71CDK80.67224752
72FES0.66979759
73JAK20.62437173
74NUAK10.62137548
75CDK30.61532890
76MAP2K60.60653463
77PRKG20.60547025
78MARK20.60225047
79FYN0.59814625
80FGFR40.58294984
81MARK30.57714080
82IGF1R0.57312973
83MAPKAPK20.56912998
84RPS6KA50.56751899
85MAP3K130.55934233
86PIK3CA0.54470465
87EIF2AK30.53948214
88ZAK0.51099636
89MAP3K70.50685417
90CAMKK20.50452892
91NTRK10.48907768
92PASK0.48715882
93PIM10.48622478
94MAP3K10.47570096
95EPHB10.47237835
96CAMK1D0.45930593
97PRKCQ0.45317764
98NLK0.42653119
99FGFR10.40929483
100EPHA30.40104952
101SMG10.39066443
102PDK10.39038872
103MAP3K50.37306662
104MAPK40.35468413
105PIM20.35436863
106CDK70.35126174
107TRIM280.34480244
108TTK0.34317433
109YES10.34080255
110INSR0.33963941
111BMPR20.32947100
112STK240.32451962
113MAP3K80.29466654
114MAP3K30.26644350
115IRAK10.26468620
116PRKCD0.25915404
117NEK90.25729565
118MAPK110.25707540
119ALK0.25348462
120MAP3K100.22690873
121PDGFRB0.22082499
122SRPK10.21947209
123TAOK20.21702987
124PRKCH0.21684921
125ATR0.21419993
126ADRBK10.21244457
127DAPK30.20973489
128RPS6KA40.20873317
129CDK40.20499089
130MAPK30.20269520
131TYRO30.20150177
132MELK0.18821960
133PIK3CG0.18756011
134ABL10.18042274
135RPS6KA60.18034090

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.88060936
2Primary immunodeficiency_Homo sapiens_hsa053403.17013871
3Other glycan degradation_Homo sapiens_hsa005112.98960455
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.81000538
5Proteasome_Homo sapiens_hsa030502.73361601
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.70268583
7Staphylococcus aureus infection_Homo sapiens_hsa051502.64361884
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.53654678
9Antigen processing and presentation_Homo sapiens_hsa046122.52369374
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.34015540
11Leishmaniasis_Homo sapiens_hsa051402.18192783
12Measles_Homo sapiens_hsa051622.17198484
13Allograft rejection_Homo sapiens_hsa053302.14396009
14T cell receptor signaling pathway_Homo sapiens_hsa046602.09025804
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.08855970
16Graft-versus-host disease_Homo sapiens_hsa053322.01768375
17Osteoclast differentiation_Homo sapiens_hsa043802.01023279
18Hematopoietic cell lineage_Homo sapiens_hsa046401.98828536
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.94554893
20B cell receptor signaling pathway_Homo sapiens_hsa046621.91813826
21Autoimmune thyroid disease_Homo sapiens_hsa053201.84377649
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.83501191
23Pertussis_Homo sapiens_hsa051331.56332893
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54180244
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54076808
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.51872166
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51405223
28Systemic lupus erythematosus_Homo sapiens_hsa053221.44297217
29Legionellosis_Homo sapiens_hsa051341.41268270
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39823926
31Toxoplasmosis_Homo sapiens_hsa051451.36837993
32Influenza A_Homo sapiens_hsa051641.34865003
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32363280
34Herpes simplex infection_Homo sapiens_hsa051681.31597584
35Asthma_Homo sapiens_hsa053101.26278446
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22433666
37Acute myeloid leukemia_Homo sapiens_hsa052211.11877303
38Chemokine signaling pathway_Homo sapiens_hsa040621.11007890
39Tuberculosis_Homo sapiens_hsa051521.09615341
40Lysosome_Homo sapiens_hsa041421.08086569
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07452014
42Apoptosis_Homo sapiens_hsa042101.05826641
43Prion diseases_Homo sapiens_hsa050201.05732794
44Malaria_Homo sapiens_hsa051441.03358025
45Hepatitis B_Homo sapiens_hsa051610.95095697
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92459763
47African trypanosomiasis_Homo sapiens_hsa051430.92028917
48Pancreatic cancer_Homo sapiens_hsa052120.88045035
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.85706635
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85363585
51Viral myocarditis_Homo sapiens_hsa054160.84067869
52TNF signaling pathway_Homo sapiens_hsa046680.80870493
53HTLV-I infection_Homo sapiens_hsa051660.78202590
54Arachidonic acid metabolism_Homo sapiens_hsa005900.74685150
55Colorectal cancer_Homo sapiens_hsa052100.74082355
56Notch signaling pathway_Homo sapiens_hsa043300.72304482
57Chronic myeloid leukemia_Homo sapiens_hsa052200.72060308
58Platelet activation_Homo sapiens_hsa046110.70734913
59Rheumatoid arthritis_Homo sapiens_hsa053230.69664592
60Shigellosis_Homo sapiens_hsa051310.67649823
61RNA polymerase_Homo sapiens_hsa030200.66270942
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.66022502
63Epstein-Barr virus infection_Homo sapiens_hsa051690.63563096
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63249696
65Type I diabetes mellitus_Homo sapiens_hsa049400.60453494
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59558540
67Oxidative phosphorylation_Homo sapiens_hsa001900.59489085
68Parkinsons disease_Homo sapiens_hsa050120.58544991
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55941264
70Fructose and mannose metabolism_Homo sapiens_hsa000510.52743066
71Hepatitis C_Homo sapiens_hsa051600.52484761
72Prolactin signaling pathway_Homo sapiens_hsa049170.49819637
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49485611
74Salmonella infection_Homo sapiens_hsa051320.48992529
75Vitamin B6 metabolism_Homo sapiens_hsa007500.47743254
76Rap1 signaling pathway_Homo sapiens_hsa040150.46989846
77MAPK signaling pathway_Homo sapiens_hsa040100.46781154
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46584280
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45738401
80Inositol phosphate metabolism_Homo sapiens_hsa005620.45615967
81Ether lipid metabolism_Homo sapiens_hsa005650.44961104
82ABC transporters_Homo sapiens_hsa020100.43649465
83Protein export_Homo sapiens_hsa030600.43621840
84Fanconi anemia pathway_Homo sapiens_hsa034600.43495767
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42832834
86Non-small cell lung cancer_Homo sapiens_hsa052230.42715338
87Pathways in cancer_Homo sapiens_hsa052000.41672330
88RNA degradation_Homo sapiens_hsa030180.38604160
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37601094
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36737928
91Base excision repair_Homo sapiens_hsa034100.36670868
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.35078837
93DNA replication_Homo sapiens_hsa030300.33968554
94Alcoholism_Homo sapiens_hsa050340.33203206
95Viral carcinogenesis_Homo sapiens_hsa052030.31618995
96Endocytosis_Homo sapiens_hsa041440.31302463
97VEGF signaling pathway_Homo sapiens_hsa043700.29763932
98Ribosome_Homo sapiens_hsa030100.28547090
99Galactose metabolism_Homo sapiens_hsa000520.28325059
100mTOR signaling pathway_Homo sapiens_hsa041500.27990198
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27945578
102Phagosome_Homo sapiens_hsa041450.27010656
103Spliceosome_Homo sapiens_hsa030400.26886032
104Homologous recombination_Homo sapiens_hsa034400.26753707
105Mismatch repair_Homo sapiens_hsa034300.26496258
106Choline metabolism in cancer_Homo sapiens_hsa052310.26119563
107Ras signaling pathway_Homo sapiens_hsa040140.26076520
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24502462
109Renal cell carcinoma_Homo sapiens_hsa052110.24219502
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.24070386
111Pyrimidine metabolism_Homo sapiens_hsa002400.22959152
112Thyroid cancer_Homo sapiens_hsa052160.22568017
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21826315
114Linoleic acid metabolism_Homo sapiens_hsa005910.21201042
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18953687
116Regulation of autophagy_Homo sapiens_hsa041400.15826266
117Alzheimers disease_Homo sapiens_hsa050100.15811592
118One carbon pool by folate_Homo sapiens_hsa006700.12460718
119Purine metabolism_Homo sapiens_hsa002300.04577485
120Caffeine metabolism_Homo sapiens_hsa002320.04531650
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.04231186
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.03684335
123Peroxisome_Homo sapiens_hsa041460.01457777
124Huntingtons disease_Homo sapiens_hsa050160.00964467
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.00421917
126N-Glycan biosynthesis_Homo sapiens_hsa005100.00162045
127Collecting duct acid secretion_Homo sapiens_hsa04966-0.0912533
128Drug metabolism - other enzymes_Homo sapiens_hsa00983-0.0868803
129HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0792740
130Cyanoamino acid metabolism_Homo sapiens_hsa00460-0.0778998
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0459160
132p53 signaling pathway_Homo sapiens_hsa04115-0.0323894
133Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0273111

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »