LAGE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the ESO/LAGE gene family, members of which are clustered together on chromosome Xq28, and have similar exon-intron structures. Unlike the other family members which are normally expressed only in testis and activated in a wide range of human tumors, this gene is ubiquitously expressed in somatic tissues. The latter, combined with the finding that it is highly conserved in mouse and rat, suggests that the encoded protein is functionally important. An intronless pseudogene with high sequence similarity to this gene is located on chromosome 9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.68486357
2ribosomal small subunit biogenesis (GO:0042274)5.63193901
3DNA deamination (GO:0045006)5.21367705
4viral transcription (GO:0019083)5.13624515
5translational termination (GO:0006415)4.98001772
6proteasome assembly (GO:0043248)4.84532775
7chaperone-mediated protein transport (GO:0072321)4.77978827
8respiratory electron transport chain (GO:0022904)4.73487587
9electron transport chain (GO:0022900)4.64751016
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.61650619
11telomere maintenance via semi-conservative replication (GO:0032201)4.61348499
12maturation of SSU-rRNA (GO:0030490)4.58150300
13ribosomal large subunit biogenesis (GO:0042273)4.52636325
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.51267397
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.49419302
16cotranslational protein targeting to membrane (GO:0006613)4.47883034
17transcription elongation from RNA polymerase III promoter (GO:0006385)4.43381450
18termination of RNA polymerase III transcription (GO:0006386)4.43381450
19protein targeting to ER (GO:0045047)4.41094151
20DNA strand elongation involved in DNA replication (GO:0006271)4.27035286
21translational elongation (GO:0006414)4.25599740
22protein localization to endoplasmic reticulum (GO:0070972)4.17088882
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.16625017
24pyrimidine nucleotide catabolic process (GO:0006244)4.15685229
25DNA strand elongation (GO:0022616)4.12083551
26telomere maintenance via recombination (GO:0000722)4.05165469
27base-excision repair, AP site formation (GO:0006285)4.03736746
28protein targeting to mitochondrion (GO:0006626)4.02972212
29protein maturation by protein folding (GO:0022417)4.00452649
30guanosine-containing compound biosynthetic process (GO:1901070)3.96305021
31deoxyribonucleotide catabolic process (GO:0009264)3.96253901
322-deoxyribonucleotide biosynthetic process (GO:0009265)3.95306266
33deoxyribose phosphate biosynthetic process (GO:0046385)3.95306266
34translational initiation (GO:0006413)3.93332031
35cellular protein complex disassembly (GO:0043624)3.93031983
36CENP-A containing nucleosome assembly (GO:0034080)3.91665191
37ribonucleoprotein complex biogenesis (GO:0022613)3.91226015
38establishment of integrated proviral latency (GO:0075713)3.90033720
39UTP biosynthetic process (GO:0006228)3.89685396
40viral life cycle (GO:0019058)3.88745607
41metallo-sulfur cluster assembly (GO:0031163)3.84260438
42iron-sulfur cluster assembly (GO:0016226)3.84260438
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.83040517
44establishment of protein localization to mitochondrion (GO:0072655)3.83035695
45rRNA modification (GO:0000154)3.82595379
46nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.81964203
47deoxyribose phosphate catabolic process (GO:0046386)3.77546185
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.75869808
49oxidative phosphorylation (GO:0006119)3.75150445
50DNA replication checkpoint (GO:0000076)3.75081180
51translation (GO:0006412)3.74980855
52kinetochore assembly (GO:0051382)3.74889950
53pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.74008261
54transcription-coupled nucleotide-excision repair (GO:0006283)3.71320216
55chromatin remodeling at centromere (GO:0031055)3.69928545
56mitotic recombination (GO:0006312)3.69503283
57telomere maintenance via telomere lengthening (GO:0010833)3.69234517
58DNA replication initiation (GO:0006270)3.69205320
597-methylguanosine mRNA capping (GO:0006370)3.68539845
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.66036470
61RNA capping (GO:0036260)3.64018026
627-methylguanosine RNA capping (GO:0009452)3.64018026
63spliceosomal snRNP assembly (GO:0000387)3.63510763
64pseudouridine synthesis (GO:0001522)3.63023944
65ATP synthesis coupled proton transport (GO:0015986)3.60755407
66energy coupled proton transport, down electrochemical gradient (GO:0015985)3.60755407
67pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.59587268
68mitochondrial respiratory chain complex I assembly (GO:0032981)3.58172257
69NADH dehydrogenase complex assembly (GO:0010257)3.58172257
70mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.58172257
71protein localization to mitochondrion (GO:0070585)3.58102164
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.58072266
73exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.57363764
74kinetochore organization (GO:0051383)3.56983615
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.56420175
76cytochrome complex assembly (GO:0017004)3.55119819
77rRNA processing (GO:0006364)3.54162732
78UTP metabolic process (GO:0046051)3.52967231
79purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.52414846
80purine nucleoside triphosphate biosynthetic process (GO:0009145)3.51150735
81cellular component biogenesis (GO:0044085)3.51068677
822-deoxyribonucleotide metabolic process (GO:0009394)3.46484280
83regulation of mitochondrial translation (GO:0070129)3.43926267
84rRNA metabolic process (GO:0016072)3.42693171
85spliceosomal complex assembly (GO:0000245)3.42385656
86protein neddylation (GO:0045116)3.42138203
87GDP-mannose metabolic process (GO:0019673)3.38703438
88CTP metabolic process (GO:0046036)3.38584697
89CTP biosynthetic process (GO:0006241)3.38584697
90protein complex disassembly (GO:0043241)3.38197075
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.37046766
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37040924
93negative regulation of ligase activity (GO:0051352)3.37040924
94regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36893298
95protein complex biogenesis (GO:0070271)3.35582335
96DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35357739
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35312099
98mitotic metaphase plate congression (GO:0007080)3.34491461
99ATP biosynthetic process (GO:0006754)3.33221805
100signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.33101393
101signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.33101393
102signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.33101393
103transcription from RNA polymerase I promoter (GO:0006360)3.32628128
104establishment of viral latency (GO:0019043)3.32569462
105nucleobase-containing small molecule interconversion (GO:0015949)3.32388631
106deoxyribose phosphate metabolic process (GO:0019692)3.31202060
107nucleobase biosynthetic process (GO:0046112)3.30925846
108intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.30842465
109signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.30842465
110ribonucleoside triphosphate biosynthetic process (GO:0009201)3.30820801
111termination of RNA polymerase I transcription (GO:0006363)3.29537933
112respiratory chain complex IV assembly (GO:0008535)3.28550903
113transcription elongation from RNA polymerase I promoter (GO:0006362)3.27742383
114pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.25752016
115signal transduction involved in DNA damage checkpoint (GO:0072422)3.24613090
116signal transduction involved in DNA integrity checkpoint (GO:0072401)3.24613090
117purine deoxyribonucleotide catabolic process (GO:0009155)3.24420294
118macromolecular complex disassembly (GO:0032984)3.23384269
119tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21137696
120RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21137696
121signal transduction involved in cell cycle checkpoint (GO:0072395)3.20682529
122GTP biosynthetic process (GO:0006183)3.19735225
123formation of translation preinitiation complex (GO:0001731)3.18740786
124regulation of cellular amino acid metabolic process (GO:0006521)3.18496439
125positive regulation of prostaglandin secretion (GO:0032308)3.17598368
126purine nucleobase biosynthetic process (GO:0009113)3.16509496
127L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.16025357
128mitochondrial transport (GO:0006839)3.13388218
129pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.12137017
130purine nucleotide salvage (GO:0032261)3.11844075
131deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.11789623
132rRNA methylation (GO:0031167)3.11768059
133mitochondrial respiratory chain complex assembly (GO:0033108)3.07819245
134nuclear-transcribed mRNA catabolic process (GO:0000956)3.07274076
135DNA replication-independent nucleosome organization (GO:0034724)3.05959273
136DNA replication-independent nucleosome assembly (GO:0006336)3.05959273
137antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.05501610
138pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.05043334
139deoxyribonucleotide biosynthetic process (GO:0009263)3.04621775
140ribosome biogenesis (GO:0042254)3.04224379
141DNA ligation (GO:0006266)3.03722974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.24533065
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.78526824
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.42001593
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.26454259
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.89621473
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.86882449
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.65879770
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.33849807
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.19339110
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.18286698
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.15957748
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.15789982
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.12178964
14CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05569226
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.02891249
16MYC_18358816_ChIP-ChIP_MESCs_Mouse3.02422014
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90152404
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.88087975
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84597616
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.84440350
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83848437
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.81841754
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.73302281
24VDR_23849224_ChIP-Seq_CD4+_Human2.55419700
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.39869548
26XRN2_22483619_ChIP-Seq_HELA_Human2.33355803
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.26995555
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.26806364
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.25464900
30FOXP3_21729870_ChIP-Seq_TREG_Human2.21728806
31DCP1A_22483619_ChIP-Seq_HELA_Human2.18500603
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14087987
33THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11833586
34YY1_21170310_ChIP-Seq_MESCs_Mouse2.10729081
35* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07095145
36ELK1_19687146_ChIP-ChIP_HELA_Human2.05245199
37TTF2_22483619_ChIP-Seq_HELA_Human2.00688328
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87362649
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86867957
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81130403
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80705882
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79494467
43* GABP_19822575_ChIP-Seq_HepG2_Human1.78571426
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74711298
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71301457
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68188938
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64584148
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62578111
49VDR_21846776_ChIP-Seq_THP-1_Human1.62566289
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56804556
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56635464
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.56588117
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51955493
54ZNF263_19887448_ChIP-Seq_K562_Human1.50853145
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49978829
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47107867
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46195574
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.45914740
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45100107
60ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.40212897
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38573256
62SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38528713
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37892837
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.37804267
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37536800
66AR_21909140_ChIP-Seq_LNCAP_Human1.33975752
67MYC_18940864_ChIP-ChIP_HL60_Human1.31493041
68* E2F1_21310950_ChIP-Seq_MCF-7_Human1.29293555
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28144784
70FOXP1_21924763_ChIP-Seq_HESCs_Human1.26296893
71IRF1_19129219_ChIP-ChIP_H3396_Human1.24790084
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.24753465
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.23719134
74CIITA_25753668_ChIP-Seq_RAJI_Human1.21933598
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.21605695
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21139108
77P68_20966046_ChIP-Seq_HELA_Human1.19039122
78BCL6_27268052_Chip-Seq_Bcells_Human1.17704675
79CTCF_26484167_Chip-Seq_Bcells_Mouse1.16106361
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14807605
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.14536543
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13868788
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11411783
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08327064
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07724613
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06180799
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04977506
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04823883
89LXR_22292898_ChIP-Seq_THP-1_Human1.03205663
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03119575
91KDM5A_27292631_Chip-Seq_BREAST_Human0.99097381
92MYC_22102868_ChIP-Seq_BL_Human0.97600691
93TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96165165
94TFEB_21752829_ChIP-Seq_HELA_Human0.95875115
95YY1_22570637_ChIP-Seq_MALME-3M_Human0.95515090
96BCOR_27268052_Chip-Seq_Bcells_Human0.92361491
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92358635
98KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92209406
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92065262
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91653272
101PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91223818
102POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90421892
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90164737
104SOX17_20123909_ChIP-Seq_XEN_Mouse0.89818498
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89514070
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89151722
107SPI1_23547873_ChIP-Seq_NB4_Human0.89069670
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88869469
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85408632
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83686456
111SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82296220
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82149340
113IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79745584
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77949098
115SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.76710550
116NANOG_16153702_ChIP-ChIP_HESCs_Human0.74839544
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73589170
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72984005
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.71284247
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.70903363
121KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.70903363
122KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.70903363
123KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.70805792
124CTCF_18555785_ChIP-Seq_MESCs_Mouse0.70118822
125FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69888594
126CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.68205998
127OCT4_18692474_ChIP-Seq_MEFs_Mouse0.67621935
128KAP1_22055183_ChIP-Seq_ESCs_Mouse0.66903961
129CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.60399810

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.38175996
2MP0010094_abnormal_chromosome_stability3.68866993
3MP0009379_abnormal_foot_pigmentation3.60326704
4MP0008057_abnormal_DNA_replication3.44224225
5MP0004957_abnormal_blastocyst_morpholog3.37952906
6MP0003111_abnormal_nucleus_morphology3.22462210
7MP0008058_abnormal_DNA_repair3.21199903
8MP0003077_abnormal_cell_cycle3.20686162
9MP0003136_yellow_coat_color3.09672347
10MP0006292_abnormal_olfactory_placode3.04231715
11MP0008932_abnormal_embryonic_tissue2.68196679
12MP0000566_synostosis2.57114111
13MP0003718_maternal_effect2.53772273
14MP0008007_abnormal_cellular_replicative2.49028374
15MP0003786_premature_aging2.19078380
16MP0003315_abnormal_perineum_morphology1.98117015
17MP0003186_abnormal_redox_activity1.97514962
18MP0001188_hyperpigmentation1.83284113
19MP0005075_abnormal_melanosome_morpholog1.80614434
20MP0002132_abnormal_respiratory_system1.77905371
21MP0002396_abnormal_hematopoietic_system1.77681566
22MP0004381_abnormal_hair_follicle1.75168228
23MP0005646_abnormal_pituitary_gland1.70388817
24MP0002234_abnormal_pharynx_morphology1.67266915
25MP0002277_abnormal_respiratory_mucosa1.65061268
26MP0001545_abnormal_hematopoietic_system1.59717431
27MP0005397_hematopoietic_system_phenotyp1.59717431
28MP0001968_abnormal_touch/_nociception1.58503815
29MP0003941_abnormal_skin_development1.56602540
30MP0001986_abnormal_taste_sensitivity1.54787999
31MP0004133_heterotaxia1.54306787
32MP0000490_abnormal_crypts_of1.53685059
33MP0002938_white_spotting1.52589878
34MP0005409_darkened_coat_color1.51071852
35MP0002736_abnormal_nociception_after1.49230127
36MP0005645_abnormal_hypothalamus_physiol1.49102964
37MP0001529_abnormal_vocalization1.47467215
38MP0001905_abnormal_dopamine_level1.47087868
39MP0002102_abnormal_ear_morphology1.45168349
40MP0004147_increased_porphyrin_level1.41492864
41MP0003806_abnormal_nucleotide_metabolis1.40619924
42MP0009278_abnormal_bone_marrow1.39897608
43MP0000372_irregular_coat_pigmentation1.38480584
44MP0009333_abnormal_splenocyte_physiolog1.33367582
45MP0005058_abnormal_lysosome_morphology1.28937218
46MP0000358_abnormal_cell_content/1.26866181
47MP0005379_endocrine/exocrine_gland_phen1.24908579
48MP0000350_abnormal_cell_proliferation1.24566527
49MP0009697_abnormal_copulation1.24228089
50MP0008877_abnormal_DNA_methylation1.24199597
51MP0001881_abnormal_mammary_gland1.23705596
52MP0005083_abnormal_biliary_tract1.22526522
53MP0006036_abnormal_mitochondrial_physio1.21136697
54MP0000313_abnormal_cell_death1.17552419
55MP0001727_abnormal_embryo_implantation1.13672166
56MP0003938_abnormal_ear_development1.11437337
57MP0000678_abnormal_parathyroid_gland1.10338102
58MP0005636_abnormal_mineral_homeostasis1.10208779
59MP0005501_abnormal_skin_physiology1.09814334
60MP0002148_abnormal_hypersensitivity_rea1.09095624
61MP0005171_absent_coat_pigmentation1.05846611
62MP0003763_abnormal_thymus_physiology1.05640885
63MP0002210_abnormal_sex_determination1.03240944
64MP0005389_reproductive_system_phenotype1.03235917
65MP0002653_abnormal_ependyma_morphology1.01555198
66MP0005670_abnormal_white_adipose1.00904894
67MP0006035_abnormal_mitochondrial_morpho1.00031167
68MP0001919_abnormal_reproductive_system0.98795042
69MP0004142_abnormal_muscle_tone0.98602898
70MP0001542_abnormal_bone_strength0.98530911
71MP0002095_abnormal_skin_pigmentation0.98157956
72MP0002019_abnormal_tumor_incidence0.97753799
73MP0000343_altered_response_to0.97614436
74MP0001853_heart_inflammation0.97488740
75MP0005408_hypopigmentation0.97426942
76MP0003567_abnormal_fetal_cardiomyocyte0.96676682
77MP0003123_paternal_imprinting0.96519832
78MP0008789_abnormal_olfactory_epithelium0.95882853
79MP0005464_abnormal_platelet_physiology0.95705267
80MP0005410_abnormal_fertilization0.95149261
81MP0002638_abnormal_pupillary_reflex0.94425624
82MP0008873_increased_physiological_sensi0.94179714
83MP0000049_abnormal_middle_ear0.93525784
84MP0001730_embryonic_growth_arrest0.93454544
85MP0002160_abnormal_reproductive_system0.93033196
86MP0000015_abnormal_ear_pigmentation0.91576778
87MP0000681_abnormal_thyroid_gland0.90031194
88MP0003937_abnormal_limbs/digits/tail_de0.89768741
89MP0005174_abnormal_tail_pigmentation0.89767102
90MP0009785_altered_susceptibility_to0.86864711
91MP0001286_abnormal_eye_development0.85749182
92MP0003866_abnormal_defecation0.85376632
93MP0001293_anophthalmia0.84864833
94MP0001145_abnormal_male_reproductive0.83695275
95MP0001186_pigmentation_phenotype0.82888000
96MP0002751_abnormal_autonomic_nervous0.82736464
97MP0004858_abnormal_nervous_system0.81263247
98MP0005451_abnormal_body_composition0.80151686
99MP0005084_abnormal_gallbladder_morpholo0.79639627
100MP0005671_abnormal_response_to0.78665423
101MP0001346_abnormal_lacrimal_gland0.78501148
102MP0000858_altered_metastatic_potential0.77815714
103MP0001764_abnormal_homeostasis0.77429597
104MP0003950_abnormal_plasma_membrane0.77360458
105MP0000465_gastrointestinal_hemorrhage0.77352048
106MP0005330_cardiomyopathy0.77112380
107MP0003011_delayed_dark_adaptation0.76541988
108MP0002163_abnormal_gland_morphology0.76395949
109MP0001119_abnormal_female_reproductive0.76244698
110MP0010030_abnormal_orbit_morphology0.74153898
111MP0008995_early_reproductive_senescence0.73267419
112MP0000689_abnormal_spleen_morphology0.72683081
113MP0000653_abnormal_sex_gland0.72267584
114MP0000750_abnormal_muscle_regeneration0.71533746
115MP0005332_abnormal_amino_acid0.71322275
116MP0001485_abnormal_pinna_reflex0.70992874
117MP0002722_abnormal_immune_system0.70566788
118MP0001697_abnormal_embryo_size0.69625101
119MP0000613_abnormal_salivary_gland0.69187656
120MP0005394_taste/olfaction_phenotype0.67942401
121MP0005499_abnormal_olfactory_system0.67942401
122MP0002085_abnormal_embryonic_tissue0.67803713
123MP0002249_abnormal_larynx_morphology0.67505212
124MP0010307_abnormal_tumor_latency0.67157288
125MP0008872_abnormal_physiological_respon0.67126562
126MP0001835_abnormal_antigen_presentation0.66867480
127MP0002837_dystrophic_cardiac_calcinosis0.66834567
128MP0002080_prenatal_lethality0.65891749
129MP0004782_abnormal_surfactant_physiolog0.65838745
130MP0002111_abnormal_tail_morphology0.65182373
131MP0000703_abnormal_thymus_morphology0.64970934
132MP0002398_abnormal_bone_marrow0.64844133
133MP0001672_abnormal_embryogenesis/_devel0.64811154
134MP0005380_embryogenesis_phenotype0.64811154
135MP0003121_genomic_imprinting0.64354698
136MP0005266_abnormal_metabolism0.63799456
137MP0002429_abnormal_blood_cell0.63127830
138MP0001929_abnormal_gametogenesis0.60290386
139MP0000639_abnormal_adrenal_gland0.59214822
140MP0005220_abnormal_exocrine_pancreas0.58817897
141MP0005584_abnormal_enzyme/coenzyme_acti0.57607008
142MP0003137_abnormal_impulse_conducting0.57487724

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.93637160
2Abnormality of cells of the erythroid lineage (HP:0012130)4.34715946
3Abnormal number of erythroid precursors (HP:0012131)4.12887328
4Acute necrotizing encephalopathy (HP:0006965)3.96871111
5Birth length less than 3rd percentile (HP:0003561)3.85159814
6Mitochondrial inheritance (HP:0001427)3.81556364
73-Methylglutaconic aciduria (HP:0003535)3.79459382
8Macrocytic anemia (HP:0001972)3.63821663
9Increased hepatocellular lipid droplets (HP:0006565)3.60487398
10Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.49982145
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47889725
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.47748991
13Abnormal mitochondria in muscle tissue (HP:0008316)3.47266040
14Increased CSF lactate (HP:0002490)3.44171784
15Hepatocellular necrosis (HP:0001404)3.42992734
16Chromsome breakage (HP:0040012)3.42800468
17Renal Fanconi syndrome (HP:0001994)3.35952600
18Breast hypoplasia (HP:0003187)3.30129360
19Acute encephalopathy (HP:0006846)3.10793397
20Pallor (HP:0000980)3.10220221
21Lipid accumulation in hepatocytes (HP:0006561)3.07977405
22Type I transferrin isoform profile (HP:0003642)3.07717652
23Progressive macrocephaly (HP:0004481)3.07367625
24Hepatic necrosis (HP:0002605)3.04412915
25Aplastic anemia (HP:0001915)3.02430535
26Increased serum lactate (HP:0002151)2.97656875
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.94719390
28Duplicated collecting system (HP:0000081)2.94599930
29Cerebral hypomyelination (HP:0006808)2.91962448
30Oral leukoplakia (HP:0002745)2.89402412
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.88653305
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.88653305
33Exertional dyspnea (HP:0002875)2.80103831
34Testicular atrophy (HP:0000029)2.77472356
35Abnormality of the preputium (HP:0100587)2.76697882
36Microvesicular hepatic steatosis (HP:0001414)2.76418622
37Petechiae (HP:0000967)2.71512996
38Progressive microcephaly (HP:0000253)2.69011053
39Ragged-red muscle fibers (HP:0003200)2.67303315
40Abnormality of glycolysis (HP:0004366)2.66263101
41Increased serum pyruvate (HP:0003542)2.66263101
42Meckel diverticulum (HP:0002245)2.65809713
43Microretrognathia (HP:0000308)2.63945198
44Rough bone trabeculation (HP:0100670)2.58548992
45Exercise intolerance (HP:0003546)2.58240338
46Abnormality of the renal collecting system (HP:0004742)2.57864925
47Abnormality of the ileum (HP:0001549)2.53160710
48Abnormality of the heme biosynthetic pathway (HP:0010472)2.52118172
49Triphalangeal thumb (HP:0001199)2.51618808
50Hyperthyroidism (HP:0000836)2.46832404
51Emotional lability (HP:0000712)2.45623526
52Lethargy (HP:0001254)2.44238800
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41318640
54Dicarboxylic aciduria (HP:0003215)2.41318640
55Hypertensive crisis (HP:0100735)2.37219468
56Absent radius (HP:0003974)2.35019335
57Respiratory difficulties (HP:0002880)2.34989072
58Increased intramyocellular lipid droplets (HP:0012240)2.29868728
59Respiratory failure (HP:0002878)2.29370295
60Absent thumb (HP:0009777)2.28663310
61Abnormality of chromosome stability (HP:0003220)2.25999417
62Pancytopenia (HP:0001876)2.25885151
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.25234074
64Lactic acidosis (HP:0003128)2.22690664
65Absent forearm bone (HP:0003953)2.21931962
66Aplasia involving forearm bones (HP:0009822)2.21931962
67Bone marrow hypocellularity (HP:0005528)2.20099337
68Patellar aplasia (HP:0006443)2.19424775
69Supernumerary spleens (HP:0009799)2.17816419
70Carpal bone hypoplasia (HP:0001498)2.14491660
71Generalized aminoaciduria (HP:0002909)2.13877648
72Asplenia (HP:0001746)2.13659509
73Parakeratosis (HP:0001036)2.12885557
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12512178
75Abnormal protein N-linked glycosylation (HP:0012347)2.12512178
76Abnormal protein glycosylation (HP:0012346)2.12512178
77Abnormal glycosylation (HP:0012345)2.12512178
78Abnormality of renal resorption (HP:0011038)2.12113554
79Premature graying of hair (HP:0002216)2.11855935
80CNS demyelination (HP:0007305)2.11293677
81Aplasia/Hypoplasia of the patella (HP:0006498)2.08410247
82Abnormal lung lobation (HP:0002101)2.07138126
83Abnormal trabecular bone morphology (HP:0100671)2.06814176
84Cleft eyelid (HP:0000625)2.06663463
85Abnormal gallbladder physiology (HP:0012438)2.04589217
86Cholecystitis (HP:0001082)2.04589217
87Duplication of thumb phalanx (HP:0009942)2.04443527
88Stenosis of the external auditory canal (HP:0000402)2.04097194
89Progressive muscle weakness (HP:0003323)2.03099880
90Optic disc pallor (HP:0000543)2.00627236
91Horseshoe kidney (HP:0000085)2.00261174
92Leukodystrophy (HP:0002415)1.99767797
93Prolonged neonatal jaundice (HP:0006579)1.98670388
94Type 2 muscle fiber atrophy (HP:0003554)1.98644363
95Hypoplasia of the radius (HP:0002984)1.97297627
96Aplasia/hypoplasia of the uterus (HP:0008684)1.97191264
97Muscle fiber atrophy (HP:0100295)1.97025638
98Myokymia (HP:0002411)1.96400771
99Duodenal stenosis (HP:0100867)1.95879306
100Small intestinal stenosis (HP:0012848)1.95879306
101Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.95713973
102Multiple enchondromatosis (HP:0005701)1.94679001
103Sparse eyelashes (HP:0000653)1.93779367
104Aplasia/Hypoplasia of the spleen (HP:0010451)1.91652728
105Cerebral edema (HP:0002181)1.90102121
106Opisthotonus (HP:0002179)1.89589967
107Colon cancer (HP:0003003)1.87551285
108True hermaphroditism (HP:0010459)1.87016926
109Concave nail (HP:0001598)1.86429092
110Truncus arteriosus (HP:0001660)1.85622563
11111 pairs of ribs (HP:0000878)1.85492710
112Methylmalonic aciduria (HP:0012120)1.84988259
113Hepatosplenomegaly (HP:0001433)1.84362965
114Hyperphosphaturia (HP:0003109)1.83793736
115Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83625634
116Abnormality of alanine metabolism (HP:0010916)1.83625634
117Hyperalaninemia (HP:0003348)1.83625634
118Abnormality of aromatic amino acid family metabolism (HP:0004338)1.82537179
119Reduced antithrombin III activity (HP:0001976)1.81053886
120Obstructive lung disease (HP:0006536)1.80524132
121Chronic obstructive pulmonary disease (HP:0006510)1.80524132
122Degeneration of anterior horn cells (HP:0002398)1.80187711
123Abnormality of the anterior horn cell (HP:0006802)1.80187711
124Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.79374947
125Secondary amenorrhea (HP:0000869)1.78859401
126X-linked dominant inheritance (HP:0001423)1.78322612
127Gliosis (HP:0002171)1.78191666
128Septo-optic dysplasia (HP:0100842)1.78087772
129Partial duplication of thumb phalanx (HP:0009944)1.78064907
130Abnormal hemoglobin (HP:0011902)1.77958790
131Pancreatic cysts (HP:0001737)1.76762464
132Abnormality of reticulocytes (HP:0004312)1.76555134
133Increased muscle lipid content (HP:0009058)1.76494134
134Hyperglycinemia (HP:0002154)1.75834000
135Hypokinesia (HP:0002375)1.74878171
136Broad distal phalanx of finger (HP:0009836)1.70875792
137Rhabdomyolysis (HP:0003201)1.67744206
138Death in infancy (HP:0001522)1.67579036
139Cerebral palsy (HP:0100021)1.66901997
140Abnormality of the fetal cardiovascular system (HP:0010948)1.65814647
141Abnormal umbilical cord blood vessels (HP:0011403)1.65814647
142Single umbilical artery (HP:0001195)1.65814647
143Seborrheic dermatitis (HP:0001051)1.62655284
144Abnormality of urine glucose concentration (HP:0011016)1.62246264
145Glycosuria (HP:0003076)1.62246264
146Fasciculations (HP:0002380)1.61689556
147Abnormality of the umbilical cord (HP:0010881)1.61604929
148Vomiting (HP:0002013)1.55831444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.05659633
2BUB14.67543799
3STK164.09949667
4WEE13.00515207
5NME22.93191235
6EIF2AK12.89264878
7PLK42.87822946
8VRK12.76964368
9SCYL22.71246673
10SRPK12.58904000
11ARAF2.58553353
12MAP3K112.46611394
13PBK2.37060527
14IRAK32.27768355
15IRAK42.16078496
16MKNK12.13261737
17TLK12.13228880
18CDC72.04301195
19EIF2AK31.90669867
20ZAK1.89742855
21TESK21.87507490
22PIM21.64069277
23NME11.61465039
24MKNK21.60766528
25CASK1.51139412
26MAPKAPK31.42458899
27PLK11.38365113
28DAPK11.38129989
29ACVR1B1.36705399
30EIF2AK21.36186455
31TTK1.33970845
32BRSK21.33339547
33MAP4K21.29956462
34IRAK21.26508939
35AURKB1.20684879
36TSSK61.20314949
37PLK31.19068423
38MST41.17171808
39TAOK21.16016978
40CDK71.15711346
41IRAK11.15485196
42CLK11.13749920
43LRRK21.12424941
44AURKA1.09561076
45ADRBK21.08725330
46CCNB11.07403177
47ILK1.06856271
48ATR1.02253382
49DYRK21.01689749
50RPS6KB21.01041496
51CHEK21.00460642
52SMG10.98291352
53KDR0.97056839
54DYRK30.96416498
55STK40.93864445
56EPHA20.93173314
57BLK0.93050690
58CDK80.91275918
59TXK0.91101784
60NEK10.90221735
61DAPK30.84645133
62MAP3K120.82823055
63ERN10.81499004
64CSNK1G20.81119604
65NUAK10.80977464
66TEC0.80559553
67CSNK1A1L0.79548609
68BMPR1B0.78969708
69NEK20.78264892
70TNIK0.77879074
71CSNK2A10.76993754
72CDK190.76830396
73CSNK1G10.76564922
74RPS6KA50.75984565
75MAP2K70.74843876
76BCR0.74775053
77ABL20.71927558
78BRAF0.70514051
79MAPKAPK50.67693172
80CSNK2A20.66938177
81LIMK10.66628739
82BRSK10.66573688
83PDK20.65690662
84TAF10.65177584
85NLK0.65125988
86YES10.64628768
87NEK60.64481525
88TBK10.63697537
89PASK0.63092010
90OXSR10.62718533
91PIM10.61449141
92STK390.59597914
93BCKDK0.56577323
94PAK40.56116497
95GRK60.55853431
96IKBKB0.54530845
97MYLK0.53633168
98PRKCI0.51435960
99MAP3K80.49955950
100TAOK30.49330340
101MAP2K20.48515324
102AKT20.47381993
103PAK10.47204359
104CHEK10.46509287
105GRK10.45928520
106GRK50.45817689
107MAP4K10.45391092
108BTK0.44390509
109LYN0.44351585
110CDK40.42736373
111MUSK0.42139742
112TIE10.42109964
113CDK30.41141842
114STK100.40700610
115CAMK2G0.40326111
116GRK70.39064730
117ATM0.38912593
118OBSCN0.38900330
119CDK11A0.37407544
120CDK140.35832091
121CDK20.35823417
122CSNK1G30.34580025
123MAPK110.34111717
124PIK3CG0.33618896
125TESK10.33515610
126AKT30.32776245
127STK38L0.32345494
128BMX0.32173868
129CDK10.31783939
130ADRBK10.31261586
131TNK20.31261381
132RPS6KA40.30703143
133UHMK10.30660889
134CDK150.30367304
135MAPK130.29983077
136MELK0.29830012
137MAP3K50.29399093
138CSNK1A10.28860427
139CDK180.27499972
140TRIM280.26211536
141FLT30.25770718
142PRKCD0.22278221
143RAF10.21396864
144CAMK2D0.21313669

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.86827192
2DNA replication_Homo sapiens_hsa030304.07926271
3RNA polymerase_Homo sapiens_hsa030203.97211305
4Proteasome_Homo sapiens_hsa030503.93245555
5Mismatch repair_Homo sapiens_hsa034303.50220521
6Homologous recombination_Homo sapiens_hsa034402.98862073
7Spliceosome_Homo sapiens_hsa030402.77509600
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.72443368
9Pyrimidine metabolism_Homo sapiens_hsa002402.68257414
10Base excision repair_Homo sapiens_hsa034102.63611681
11Oxidative phosphorylation_Homo sapiens_hsa001902.62103461
12Nucleotide excision repair_Homo sapiens_hsa034202.61572859
13Protein export_Homo sapiens_hsa030602.36019973
14Parkinsons disease_Homo sapiens_hsa050122.31928426
15Fanconi anemia pathway_Homo sapiens_hsa034602.26606898
16Non-homologous end-joining_Homo sapiens_hsa034502.01753371
17Basal transcription factors_Homo sapiens_hsa030221.96842957
18RNA transport_Homo sapiens_hsa030131.96342559
19Huntingtons disease_Homo sapiens_hsa050161.92916678
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86080749
21Cell cycle_Homo sapiens_hsa041101.66896366
22RNA degradation_Homo sapiens_hsa030181.56739642
23One carbon pool by folate_Homo sapiens_hsa006701.56430532
24Purine metabolism_Homo sapiens_hsa002301.53204850
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49033951
26Alzheimers disease_Homo sapiens_hsa050101.47309624
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46350868
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44580909
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.34280580
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32309869
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22518617
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14470807
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06636050
34p53 signaling pathway_Homo sapiens_hsa041151.06493999
35Carbon metabolism_Homo sapiens_hsa012001.05201747
36Folate biosynthesis_Homo sapiens_hsa007901.04174875
37Arachidonic acid metabolism_Homo sapiens_hsa005900.96373727
38Pyruvate metabolism_Homo sapiens_hsa006200.93472782
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92278006
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90546306
41Epstein-Barr virus infection_Homo sapiens_hsa051690.89207780
42Glutathione metabolism_Homo sapiens_hsa004800.86460306
43mRNA surveillance pathway_Homo sapiens_hsa030150.83966504
44Steroid biosynthesis_Homo sapiens_hsa001000.83132505
45Collecting duct acid secretion_Homo sapiens_hsa049660.80957283
46Fatty acid elongation_Homo sapiens_hsa000620.75848121
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74697706
48Systemic lupus erythematosus_Homo sapiens_hsa053220.73625461
49Primary immunodeficiency_Homo sapiens_hsa053400.73505000
50Vitamin B6 metabolism_Homo sapiens_hsa007500.73232699
51Sulfur relay system_Homo sapiens_hsa041220.70378853
52Galactose metabolism_Homo sapiens_hsa000520.69453766
53Metabolic pathways_Homo sapiens_hsa011000.66000145
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.62737344
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62697834
56Linoleic acid metabolism_Homo sapiens_hsa005910.62443577
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62084534
58Ether lipid metabolism_Homo sapiens_hsa005650.61386910
59Vibrio cholerae infection_Homo sapiens_hsa051100.59814045
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59608863
61Asthma_Homo sapiens_hsa053100.58772406
62Sphingolipid metabolism_Homo sapiens_hsa006000.58392074
63Autoimmune thyroid disease_Homo sapiens_hsa053200.56468804
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56262894
65Herpes simplex infection_Homo sapiens_hsa051680.56019545
66Synaptic vesicle cycle_Homo sapiens_hsa047210.52482985
67Pentose phosphate pathway_Homo sapiens_hsa000300.51236996
68Phenylalanine metabolism_Homo sapiens_hsa003600.48867242
69Cardiac muscle contraction_Homo sapiens_hsa042600.48811020
70Allograft rejection_Homo sapiens_hsa053300.47548642
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45353665
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44004089
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43306737
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41705337
75Graft-versus-host disease_Homo sapiens_hsa053320.41658902
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.41480244
77Other glycan degradation_Homo sapiens_hsa005110.39964400
78Arginine and proline metabolism_Homo sapiens_hsa003300.39373426
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38650929
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.36615329
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35423168
82Hematopoietic cell lineage_Homo sapiens_hsa046400.33280424
83Antigen processing and presentation_Homo sapiens_hsa046120.32573902
84Fatty acid metabolism_Homo sapiens_hsa012120.31668571
85Propanoate metabolism_Homo sapiens_hsa006400.28649435
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.27900931
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26964804
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26314719
89N-Glycan biosynthesis_Homo sapiens_hsa005100.25669504
90Regulation of autophagy_Homo sapiens_hsa041400.24902727
91Viral carcinogenesis_Homo sapiens_hsa052030.22988624
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22872999
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.20786544
94Shigellosis_Homo sapiens_hsa051310.20089957
95Sulfur metabolism_Homo sapiens_hsa009200.19237549
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19158165
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18670221
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.18616936
99Legionellosis_Homo sapiens_hsa051340.18335081
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17964052
101Butanoate metabolism_Homo sapiens_hsa006500.17641606
102Phototransduction_Homo sapiens_hsa047440.17501716
103Peroxisome_Homo sapiens_hsa041460.16807001
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16780097
105Vitamin digestion and absorption_Homo sapiens_hsa049770.16566153
106Rheumatoid arthritis_Homo sapiens_hsa053230.16203155
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16045907
108Lysosome_Homo sapiens_hsa041420.15873319
109Tyrosine metabolism_Homo sapiens_hsa003500.15781094
110HTLV-I infection_Homo sapiens_hsa051660.15132237
111Measles_Homo sapiens_hsa051620.15095296
112Biosynthesis of amino acids_Homo sapiens_hsa012300.14752338
113Retinol metabolism_Homo sapiens_hsa008300.14566440
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14555448
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14433046
116Basal cell carcinoma_Homo sapiens_hsa052170.14366120
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13737202
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13099246
119Alcoholism_Homo sapiens_hsa050340.12676884
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12410303
121Fructose and mannose metabolism_Homo sapiens_hsa000510.11926319
122Oocyte meiosis_Homo sapiens_hsa041140.10689306
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.10572584
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.09290612
125Malaria_Homo sapiens_hsa051440.08988647
126Selenocompound metabolism_Homo sapiens_hsa004500.06236795

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