ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pre-miRNA processing (GO:0031054)	8.44869881
2	detection of light stimulus involved in visual perception (GO:0050908)	6.94345203
3	detection of light stimulus involved in sensory perception (GO:0050962)	6.94345203
4	regulation of chromatin binding (GO:0035561)	6.60554562
5	piRNA metabolic process (GO:0034587)	6.59607824
6	protein heterotetramerization (GO:0051290)	5.89435560
7	adult feeding behavior (GO:0008343)	5.69231784
8	dorsal/ventral axis specification (GO:0009950)	5.65644246
9	ectoderm development (GO:0007398)	5.36742044
10	vascular smooth muscle contraction (GO:0014829)	4.87147712
11	synapsis (GO:0007129)	4.83374235
12	positive regulation of fat cell differentiation (GO:0045600)	4.73659905
13	embryonic eye morphogenesis (GO:0048048)	4.66170645
14	DNA methylation involved in gamete generation (GO:0043046)	4.63185270
15	regulation of feeding behavior (GO:0060259)	4.53046643
16	ncRNA catabolic process (GO:0034661)	4.35959222
17	male meiosis I (GO:0007141)	4.35123339
18	hyperosmotic salinity response (GO:0042538)	4.24354055
19	water-soluble vitamin biosynthetic process (GO:0042364)	4.12080363
20	male sex determination (GO:0030238)	4.10085814
21	urogenital system development (GO:0001655)	4.07432672
22	inositol phosphate catabolic process (GO:0071545)	3.89972668
23	photoreceptor cell maintenance (GO:0045494)	3.88859236
24	chromosome organization involved in meiosis (GO:0070192)	3.86199002
25	nonmotile primary cilium assembly (GO:0035058)	3.85275625
26	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.84260200
27	gamma-aminobutyric acid transport (GO:0015812)	3.79901392
28	histone mRNA catabolic process (GO:0071044)	3.71858015
29	meiotic cell cycle (GO:0051321)	3.67981870
30	meiotic chromosome segregation (GO:0045132)	3.64973956
31	regulation of axon extension involved in axon guidance (GO:0048841)	3.60993348
32	hypotonic response (GO:0006971)	3.56847800
33	neuron remodeling (GO:0016322)	3.54023575
34	Leydig cell differentiation (GO:0033327)	3.52279055
35	sodium ion export (GO:0071436)	3.51618974
36	intraciliary transport (GO:0042073)	3.43609703
37	ganglion development (GO:0061548)	3.40920853
38	L-serine metabolic process (GO:0006563)	3.37063582
39	cellular response to zinc ion (GO:0071294)	3.35712724
40	microtubule polymerization or depolymerization (GO:0031109)	3.31199391
41	polyol catabolic process (GO:0046174)	3.28258055
42	reciprocal meiotic recombination (GO:0007131)	3.26463322
43	reciprocal DNA recombination (GO:0035825)	3.26463322
44	regulation of axon guidance (GO:1902667)	3.24647140
45	meiosis I (GO:0007127)	3.23684554
46	regulation of cilium movement (GO:0003352)	3.17015450
47	regulation of response to osmotic stress (GO:0047484)	3.16991361
48	synaptonemal complex assembly (GO:0007130)	3.16071712
49	cellular response to ATP (GO:0071318)	3.11036908
50	spinal cord motor neuron differentiation (GO:0021522)	3.06024514
51	tachykinin receptor signaling pathway (GO:0007217)	3.05499697
52	rRNA methylation (GO:0031167)	3.05239772
53	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.01471054
54	spermatid development (GO:0007286)	3.00339030
55	male meiosis (GO:0007140)	2.97954051
56	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.97455786
57	DNA synthesis involved in DNA repair (GO:0000731)	2.96182939
58	regulation of protein kinase A signaling (GO:0010738)	2.94013125
59	vitamin catabolic process (GO:0009111)	2.93867855
60	fat-soluble vitamin catabolic process (GO:0042363)	2.93867855
61	short-term memory (GO:0007614)	2.91708702
62	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.89749606
63	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.89565891
64	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.88898188
65	response to caffeine (GO:0031000)	2.87550503
66	synaptonemal complex organization (GO:0070193)	2.87119470
67	ephrin receptor signaling pathway (GO:0048013)	2.85106062
68	neurofilament cytoskeleton organization (GO:0060052)	2.84085823
69	regulation of neuron migration (GO:2001222)	2.84071890
70	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.83889409
71	sensory perception of smell (GO:0007608)	2.83178204
72	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	2.82174868
73	glyoxylate metabolic process (GO:0046487)	2.80633352
74	histone-serine phosphorylation (GO:0035404)	2.80618070
75	homocysteine metabolic process (GO:0050667)	2.79917515
76	meiotic nuclear division (GO:0007126)	2.79887015
77	forebrain development (GO:0030900)	2.79271787
78	sex determination (GO:0007530)	2.78379989
79	pteridine-containing compound biosynthetic process (GO:0042559)	2.77125717
80	photoperiodism (GO:0009648)	2.71834950
81	rhodopsin mediated signaling pathway (GO:0016056)	2.71562802
82	regulation of meiosis I (GO:0060631)	2.67170418
83	post-embryonic morphogenesis (GO:0009886)	2.65269937
84	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.61950192
85	L-fucose catabolic process (GO:0042355)	2.61857392
86	fucose catabolic process (GO:0019317)	2.61857392
87	L-fucose metabolic process (GO:0042354)	2.61857392
88	cytoplasmic microtubule organization (GO:0031122)	2.61650646
89	neural tube formation (GO:0001841)	2.59597872
90	protein K11-linked deubiquitination (GO:0035871)	2.58080148
91	negative regulation of response to food (GO:0032096)	2.57392391
92	negative regulation of appetite (GO:0032099)	2.57392391
93	microtubule anchoring (GO:0034453)	2.56818760
94	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.56351421
95	estrogen biosynthetic process (GO:0006703)	2.56062974
96	entrainment of circadian clock (GO:0009649)	2.54874066
97	cochlea morphogenesis (GO:0090103)	2.54722507
98	negative regulation of axon guidance (GO:1902668)	2.52836659
99	DNA strand renaturation (GO:0000733)	2.50302418
100	serine family amino acid catabolic process (GO:0009071)	2.50226101

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	5.50834164
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.81909864
3	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	3.63519209
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.05112148
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.76974076
6	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.74722063
7	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.69891251
8	RNF2_27304074_Chip-Seq_NSC_Mouse	2.63797531
9	FUS_26573619_Chip-Seq_HEK293_Human	2.61309817
10	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.17248527
11	EZH2_22144423_ChIP-Seq_EOC_Human	10.5156165
12	RXR_22108803_ChIP-Seq_LS180_Human	1.97865724
13	TP53_16413492_ChIP-PET_HCT116_Human	1.92532030
14	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.92032788
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.90537072
16	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.88098581
17	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.80191725
18	EWS_26573619_Chip-Seq_HEK293_Human	1.77619642
19	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.73217496
20	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.72785909
21	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.71007967
22	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.61556994
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.60202118
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.58109521
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.57405329
26	HTT_18923047_ChIP-ChIP_STHdh_Human	1.54626912
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.52848639
28	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.52162302
29	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.51973015
30	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.50979379
31	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.47231073
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39161189
33	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.39161189
34	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.38820629
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33458421
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32957895
37	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.32410633
38	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.28730808
39	ERA_21632823_ChIP-Seq_H3396_Human	1.28374916
40	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.27618801
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26280269
42	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25742467
43	ZNF274_21170338_ChIP-Seq_K562_Hela	1.23551349
44	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.23190989
45	VDR_22108803_ChIP-Seq_LS180_Human	1.21479455
46	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.19193978
47	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.16658137
48	MYC_18940864_ChIP-ChIP_HL60_Human	1.15701816
49	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.12906425
50	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.12906425
51	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.12560285
52	STAT3_23295773_ChIP-Seq_U87_Human	1.11354273
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10484201
54	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.09929474
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09789073
56	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.07868906
57	GBX2_23144817_ChIP-Seq_PC3_Human	1.07840749
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.06380220
59	SMAD4_21799915_ChIP-Seq_A2780_Human	1.04864146
60	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04829143
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.03575337
62	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.02514609
63	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00540507
64	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98784845
65	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.97673582
66	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.96843603
67	P300_19829295_ChIP-Seq_ESCs_Human	0.94731887
68	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.94098811
69	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.93444455
70	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.93266095
71	BCAT_22108803_ChIP-Seq_LS180_Human	0.92900737
72	REST_21632747_ChIP-Seq_MESCs_Mouse	0.92531883
73	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.91727370
74	RUNX2_22187159_ChIP-Seq_PCA_Human	0.91206027
75	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.90123317
76	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.88537974
77	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.88049362
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.87717315
79	MYC_19829295_ChIP-Seq_ESCs_Human	0.87105497
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.86643370
81	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.86277925
82	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.85724187
83	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.84746164
84	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.84250852
85	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.84249876
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.84249876
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.83669647
88	NCOR_22424771_ChIP-Seq_293T_Human	0.83580571
89	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.82832663
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.82570763
91	CTCF_27219007_Chip-Seq_Bcells_Human	0.82106596
92	CBP_20019798_ChIP-Seq_JUKART_Human	0.81303696
93	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.81303696
94	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.80417368
95	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.80061867
96	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.79350415
97	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.79233209
98	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.78346945
99	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.77840123
100	ER_23166858_ChIP-Seq_MCF-7_Human	0.77394397

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	5.21458543
2	MP0008789_abnormal_olfactory_epithelium	4.87456996
3	MP0005423_abnormal_somatic_nervous	4.18223944
4	MP0000569_abnormal_digit_pigmentation	3.85785549
5	MP0005394_taste/olfaction_phenotype	3.70793764
6	MP0005499_abnormal_olfactory_system	3.70793764
7	MP0005645_abnormal_hypothalamus_physiol	3.47718303
8	MP0001542_abnormal_bone_strength	3.47555732
9	MP0003315_abnormal_perineum_morphology	3.41922965
10	MP0002163_abnormal_gland_morphology	3.20988611
11	MP0010030_abnormal_orbit_morphology	3.16084001
12	MP0002160_abnormal_reproductive_system	3.06546759
13	MP0001986_abnormal_taste_sensitivity	3.01389603
14	MP0003890_abnormal_embryonic-extraembry	2.66044825
15	MP0005670_abnormal_white_adipose	2.32817758
16	MP0005410_abnormal_fertilization	2.15199690
17	MP0002735_abnormal_chemical_nociception	2.09183360
18	MP0003950_abnormal_plasma_membrane	2.06223336
19	MP0005174_abnormal_tail_pigmentation	1.97543235
20	MP0006276_abnormal_autonomic_nervous	1.97442878
21	MP0005389_reproductive_system_phenotype	1.96467021
22	MP0005551_abnormal_eye_electrophysiolog	1.89666891
23	MP0005379_endocrine/exocrine_gland_phen	1.68653871
24	MP0002210_abnormal_sex_determination	1.67647306
25	MP0002233_abnormal_nose_morphology	1.59672593
26	MP0000015_abnormal_ear_pigmentation	1.57713291
27	MP0006292_abnormal_olfactory_placode	1.50726674
28	MP0000778_abnormal_nervous_system	1.50232740
29	MP0003136_yellow_coat_color	1.47781279
30	MP0001346_abnormal_lacrimal_gland	1.45858216
31	MP0008058_abnormal_DNA_repair	1.43494258
32	MP0003011_delayed_dark_adaptation	1.42245690
33	MP0008877_abnormal_DNA_methylation	1.42130317
34	MP0000653_abnormal_sex_gland	1.35383568
35	MP0003045_fibrosis	1.33082192
36	MP0002653_abnormal_ependyma_morphology	1.32500078
37	MP0001145_abnormal_male_reproductive	1.31022632
38	MP0001119_abnormal_female_reproductive	1.23125551
39	MP0001929_abnormal_gametogenesis	1.19378539
40	MP0002822_catalepsy	1.15058326
41	MP0001984_abnormal_olfaction	1.12168500
42	MP0003698_abnormal_male_reproductive	1.10042496
43	MP0002734_abnormal_mechanical_nocicepti	1.08346289
44	MP0001299_abnormal_eye_distance/	1.06379733
45	MP0000003_abnormal_adipose_tissue	1.04856793
46	MP0002272_abnormal_nervous_system	1.03805188
47	MP0005367_renal/urinary_system_phenotyp	1.03635129
48	MP0000516_abnormal_urinary_system	1.03635129
49	MP0005171_absent_coat_pigmentation	1.00375374
50	MP0002184_abnormal_innervation	1.00290484
51	MP0009046_muscle_twitch	0.99670291
52	MP0002234_abnormal_pharynx_morphology	0.97841956
53	MP0005195_abnormal_posterior_eye	0.95916206
54	MP0009250_abnormal_appendicular_skeleto	0.94383576
55	MP0010368_abnormal_lymphatic_system	0.92294227
56	MP0004133_heterotaxia	0.90893322
57	MP0000537_abnormal_urethra_morphology	0.89582744
58	MP0001286_abnormal_eye_development	0.89247843
59	MP0002752_abnormal_somatic_nervous	0.88104996
60	MP0005083_abnormal_biliary_tract	0.86629150
61	MP0001529_abnormal_vocalization	0.85505474
62	MP0003279_aneurysm	0.81398093
63	MP0005646_abnormal_pituitary_gland	0.80547613
64	MP0001324_abnormal_eye_pigmentation	0.80539261
65	MP0001293_anophthalmia	0.79090549
66	MP0001661_extended_life_span	0.76361237
67	MP0008775_abnormal_heart_ventricle	0.76046921
68	MP0000538_abnormal_urinary_bladder	0.75161742
69	MP0002168_other_aberrant_phenotype	0.72300637
70	MP0009278_abnormal_bone_marrow	0.71872121
71	MP0001879_abnormal_lymphatic_vessel	0.71321704
72	MP0002882_abnormal_neuron_morphology	0.70408836
73	MP0003861_abnormal_nervous_system	0.68976229
74	MP0005375_adipose_tissue_phenotype	0.68021460
75	MP0002909_abnormal_adrenal_gland	0.67615812
76	MP0002282_abnormal_trachea_morphology	0.67122512
77	MP0002095_abnormal_skin_pigmentation	0.66654763
78	MP0009745_abnormal_behavioral_response	0.66597795
79	MP0002697_abnormal_eye_size	0.64409108
80	MP0002557_abnormal_social/conspecific_i	0.63814440
81	MP0004142_abnormal_muscle_tone	0.63256079
82	MP0000427_abnormal_hair_cycle	0.63046995
83	MP0001970_abnormal_pain_threshold	0.61092390
84	MP0002161_abnormal_fertility/fecundity	0.60296384
85	MP0006035_abnormal_mitochondrial_morpho	0.59704573
86	MP0006072_abnormal_retinal_apoptosis	0.59508149
87	MP0000026_abnormal_inner_ear	0.58047892
88	MP0004019_abnormal_vitamin_homeostasis	0.55569040
89	MP0001919_abnormal_reproductive_system	0.55194626
90	MP0008875_abnormal_xenobiotic_pharmacok	0.54901205
91	MP0005253_abnormal_eye_physiology	0.53632513
92	MP0002938_white_spotting	0.53454770
93	MP0004883_abnormal_blood_vessel	0.52781367
94	MP0001968_abnormal_touch/_nociception	0.52645428
95	MP0005391_vision/eye_phenotype	0.51978551
96	MP0001486_abnormal_startle_reflex	0.51819773
97	MP0008770_decreased_survivor_rate	0.51728465
98	MP0005448_abnormal_energy_balance	0.50601571
99	MP0008260_abnormal_autophagy	0.50075408
100	MP0000749_muscle_degeneration	0.50055031

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplasia of the uterus (HP:0000013)	5.42376269
2	Aplasia of the musculature (HP:0100854)	4.81573415
3	Rib fusion (HP:0000902)	4.70477155
4	Abnormal sex determination (HP:0012244)	4.69694378
5	Sex reversal (HP:0012245)	4.69694378
6	Hand muscle atrophy (HP:0009130)	4.68922681
7	Fetal akinesia sequence (HP:0001989)	4.47977999
8	Hip dysplasia (HP:0001385)	4.25387227
9	Bony spicule pigmentary retinopathy (HP:0007737)	4.06951645
10	Carpal bone hypoplasia (HP:0001498)	3.91825210
11	Hip contracture (HP:0003273)	3.88750568
12	Spinal muscular atrophy (HP:0007269)	3.79383704
13	Aplasia/hypoplasia of the uterus (HP:0008684)	3.75706247
14	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.51468293
15	Small hand (HP:0200055)	3.50802339
16	Distal upper limb amyotrophy (HP:0007149)	3.46332378
17	Upper limb amyotrophy (HP:0009129)	3.46332378
18	Diaphragmatic weakness (HP:0009113)	3.19227484
19	Stridor (HP:0010307)	3.18463509
20	Down-sloping shoulders (HP:0200021)	3.17705629
21	Muscle fiber splitting (HP:0003555)	3.10100518
22	Supernumerary spleens (HP:0009799)	3.09293872
23	Abnormality of the middle phalanges of the toes (HP:0010183)	3.01585692
24	Limb-girdle muscle atrophy (HP:0003797)	2.96641552
25	Methylmalonic acidemia (HP:0002912)	2.89174858
26	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.88260872
27	Medial flaring of the eyebrow (HP:0010747)	2.86728106
28	Pancreatic fibrosis (HP:0100732)	2.75881129
29	Knee flexion contracture (HP:0006380)	2.75852995
30	Gait imbalance (HP:0002141)	2.73723249
31	Nephronophthisis (HP:0000090)	2.72930420
32	Nonprogressive disorder (HP:0003680)	2.70356938
33	Limited hip movement (HP:0008800)	2.67014489
34	Abnormality of the vocal cords (HP:0008777)	2.65040620
35	Congenital primary aphakia (HP:0007707)	2.64298086
36	Increased hepatocellular lipid droplets (HP:0006565)	2.62176194
37	Osteomalacia (HP:0002749)	2.60758082
38	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.59361987
39	Abnormality of renal resorption (HP:0011038)	2.56065509
40	Hyperglycinemia (HP:0002154)	2.55304899
41	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	2.51869501
42	Abnormality of the renal medulla (HP:0100957)	2.50213275
43	Short tibia (HP:0005736)	2.47462414
44	Broad-based gait (HP:0002136)	2.47359320
45	Abnormal number of erythroid precursors (HP:0012131)	2.41010573
46	Abnormality of cells of the erythroid lineage (HP:0012130)	2.36488557
47	Hypoplasia of the pons (HP:0012110)	2.35488242
48	Male pseudohermaphroditism (HP:0000037)	2.35467449
49	Pancreatic cysts (HP:0001737)	2.34991164
50	Epiphyseal dysplasia (HP:0002656)	2.34026209
51	Obstructive sleep apnea (HP:0002870)	2.31679425
52	Anencephaly (HP:0002323)	2.30338183
53	Congenital stationary night blindness (HP:0007642)	2.30165756
54	Abnormality of the phalanges of the hallux (HP:0010057)	2.28145077
55	Nephrogenic diabetes insipidus (HP:0009806)	2.26271197
56	Gonadal dysgenesis (HP:0000133)	2.26131622
57	True hermaphroditism (HP:0010459)	2.25646746
58	Vertebral arch anomaly (HP:0008438)	2.25022951
59	Barrel-shaped chest (HP:0001552)	2.22804322
60	Tubular atrophy (HP:0000092)	2.22043379
61	Abnormality of the pons (HP:0007361)	2.19405700
62	Spinal cord compression (HP:0002176)	2.18024725
63	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.17548147
64	Abnormality of the musculature of the hand (HP:0001421)	2.16184941
65	Lipid accumulation in hepatocytes (HP:0006561)	2.15256727
66	Supernumerary bones of the axial skeleton (HP:0009144)	2.11578147
67	Abnormality of midbrain morphology (HP:0002418)	2.11477528
68	Molar tooth sign on MRI (HP:0002419)	2.11477528
69	Methylmalonic aciduria (HP:0012120)	2.10995220
70	Hypoplasia of the odontoid process (HP:0003311)	2.08035226
71	Sleep apnea (HP:0010535)	2.07274603
72	Abnormality of the intervertebral disk (HP:0005108)	2.04050718
73	Attenuation of retinal blood vessels (HP:0007843)	2.03587289
74	Flat acetabular roof (HP:0003180)	2.02569625
75	Metaphyseal irregularity (HP:0003025)	1.98145455
76	Supernumerary ribs (HP:0005815)	1.97745676
77	Abdominal situs inversus (HP:0003363)	1.97645303
78	Abnormality of abdominal situs (HP:0011620)	1.97645303
79	Rimmed vacuoles (HP:0003805)	1.96560240
80	Scapular winging (HP:0003691)	1.95687672
81	Concave nail (HP:0001598)	1.93632327
82	Poor coordination (HP:0002370)	1.90235555
83	Abnormality of the renal cortex (HP:0011035)	1.88685859
84	Congenital hepatic fibrosis (HP:0002612)	1.84986901
85	Disproportionate short-trunk short stature (HP:0003521)	1.84886501
86	Renal Fanconi syndrome (HP:0001994)	1.83874468
87	Cerebellar dysplasia (HP:0007033)	1.83072763
88	Urinary urgency (HP:0000012)	1.82905129
89	Achilles tendon contracture (HP:0001771)	1.82583724
90	Abnormality of the distal phalanges of the toes (HP:0010182)	1.81406282
91	Tubulointerstitial nephritis (HP:0001970)	1.77007904
92	Abnormal number of incisors (HP:0011064)	1.76228498
93	Short middle phalanx of finger (HP:0005819)	1.72946572
94	Midline defect of the nose (HP:0004122)	1.72936840
95	Genital tract atresia (HP:0001827)	1.71589869
96	Postaxial hand polydactyly (HP:0001162)	1.71048055
97	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.69575253
98	Retinitis pigmentosa (HP:0000510)	1.69060267
99	Macrocytic anemia (HP:0001972)	1.68459631
100	Type II lissencephaly (HP:0007260)	1.67878309

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	4.52872609
2	STK39	3.81340418
3	EPHB2	3.10173058
4	MAP4K2	2.76571830
5	STK38	2.64243019
6	MAP2K7	2.52242242
7	BRD4	2.42510620
8	CLK1	2.39442887
9	MAPKAPK3	2.33963117
10	MARK1	2.29028761
11	BRSK2	2.27486470
12	MAP3K4	2.25299357
13	WEE1	2.24497210
14	PNCK	2.13295915
15	EPHA4	1.95303344
16	MAPK15	1.93701843
17	TAF1	1.78178364
18	VRK1	1.74951389
19	PLK4	1.69700287
20	TLK1	1.55894578
21	ZAK	1.48941967
22	BRSK1	1.33400867
23	BMPR1B	1.20802939
24	PRKCG	1.20687616
25	DYRK2	1.20266391
26	CSNK1G2	1.18588779
27	FER	1.17740216
28	FRK	1.17387615
29	PRKD3	1.16337500
30	MAP3K7	1.16212619
31	MINK1	1.13121740
32	OXSR1	1.11035655
33	BCR	1.07922821
34	INSRR	1.07876252
35	PIK3CA	1.06826112
36	RPS6KA2	1.05788725
37	KSR1	1.04938466
38	GRK1	1.04216100
39	STK11	1.01834207
40	PLK2	0.97671604
41	DDR2	0.96921365
42	WNK3	0.96481845
43	TESK2	0.93596663
44	CDC7	0.92957133
45	MKNK2	0.91479830
46	NEK9	0.88436674
47	CSNK1E	0.85296845
48	CHEK2	0.80448668
49	SGK1	0.80275583
50	CSNK1A1L	0.79826754
51	MAP3K3	0.79746404
52	TTK	0.75862836
53	PTK2B	0.71358492
54	DYRK1A	0.68342913
55	STK16	0.68136498
56	MAP3K6	0.66897034
57	TNK2	0.66839069
58	NEK2	0.66677467
59	MAP2K1	0.66632410
60	CSNK1G3	0.66545731
61	MAPK8	0.66397904
62	AKT3	0.65896697
63	PAK3	0.63899857
64	RPS6KA6	0.63269653
65	MUSK	0.60804933
66	CDK1	0.60587178
67	ATR	0.60424490
68	PRKCE	0.59625632
69	NUAK1	0.59314368
70	ADRBK2	0.59222071
71	TRIM28	0.58741034
72	PRKCD	0.58740131
73	PRKAA1	0.57906116
74	NLK	0.56059102
75	STK4	0.55809965
76	STK3	0.55487251
77	MAPK13	0.54741817
78	RPS6KL1	0.51781384
79	RPS6KC1	0.51781384
80	CSNK1G1	0.51718511
81	PLK3	0.50296029
82	LATS1	0.49959402
83	CSNK1A1	0.49910503
84	PRKACA	0.49705035
85	EPHA2	0.47431232
86	ADRBK1	0.46434542
87	CDK7	0.46148166
88	GSK3B	0.45726528
89	AURKA	0.45195276
90	PASK	0.44551548
91	CSNK2A1	0.44368050
92	CSNK2A2	0.43961890
93	KSR2	0.43158315
94	PLK1	0.42843079
95	MAPK9	0.42841016
96	WNK1	0.42192141
97	ATM	0.42139246
98	RPS6KA5	0.37527553
99	DYRK3	0.37502767
100	BUB1	0.36144136

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	4.26090722
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.74060900
3	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.85709873
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.63275843
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.34794465
6	Sulfur relay system_Homo sapiens_hsa04122	2.33108199
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.29815543
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.27237261
9	Non-homologous end-joining_Homo sapiens_hsa03450	2.25587305
10	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.14931862
11	Regulation of autophagy_Homo sapiens_hsa04140	2.06896368
12	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.03904319
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.01659952
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.94184938
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.93706406
16	Ribosome_Homo sapiens_hsa03010	1.91542524
17	Parkinsons disease_Homo sapiens_hsa05012	1.90221616
18	Protein export_Homo sapiens_hsa03060	1.82427106
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.78954346
20	Homologous recombination_Homo sapiens_hsa03440	1.69402623
21	Mineral absorption_Homo sapiens_hsa04978	1.59168663
22	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.53796649
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.52040956
24	One carbon pool by folate_Homo sapiens_hsa00670	1.48589307
25	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.46552333
26	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.40671127
27	Glycerolipid metabolism_Homo sapiens_hsa00561	1.38816890
28	Nicotine addiction_Homo sapiens_hsa05033	1.37908004
29	Basal cell carcinoma_Homo sapiens_hsa05217	1.35915173
30	Fatty acid elongation_Homo sapiens_hsa00062	1.34556623
31	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.34265349
32	Base excision repair_Homo sapiens_hsa03410	1.33864035
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.30841097
34	Huntingtons disease_Homo sapiens_hsa05016	1.30629061
35	Alzheimers disease_Homo sapiens_hsa05010	1.28398183
36	Phenylalanine metabolism_Homo sapiens_hsa00360	1.25788292
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.25371279
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.18078747
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.14185196
40	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.13548351
41	Linoleic acid metabolism_Homo sapiens_hsa00591	1.13494122
42	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.13407333
43	Circadian rhythm_Homo sapiens_hsa04710	1.10143708
44	Axon guidance_Homo sapiens_hsa04360	1.05638175
45	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.03991525
46	ABC transporters_Homo sapiens_hsa02010	1.00320320
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.95846253
48	Olfactory transduction_Homo sapiens_hsa04740	0.92421947
49	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.91686078
50	Fatty acid metabolism_Homo sapiens_hsa01212	0.87861684
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85854764
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.85719654
53	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.85116730
54	GABAergic synapse_Homo sapiens_hsa04727	0.84609664
55	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.83011379
56	Butanoate metabolism_Homo sapiens_hsa00650	0.81567361
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.81066325
58	Nitrogen metabolism_Homo sapiens_hsa00910	0.80629362
59	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.73982364
60	Peroxisome_Homo sapiens_hsa04146	0.73970940
61	Proteasome_Homo sapiens_hsa03050	0.67544069
62	Notch signaling pathway_Homo sapiens_hsa04330	0.67492869
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66528778
64	Taste transduction_Homo sapiens_hsa04742	0.65724387
65	RNA transport_Homo sapiens_hsa03013	0.65489281
66	Arginine and proline metabolism_Homo sapiens_hsa00330	0.63972100
67	Metabolic pathways_Homo sapiens_hsa01100	0.63050252
68	Morphine addiction_Homo sapiens_hsa05032	0.62858604
69	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.62715163
70	Basal transcription factors_Homo sapiens_hsa03022	0.59145419
71	p53 signaling pathway_Homo sapiens_hsa04115	0.56294007
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.55645332
73	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.55332939
74	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.54367512
75	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.54132314
76	Glutathione metabolism_Homo sapiens_hsa00480	0.51873722
77	Fatty acid degradation_Homo sapiens_hsa00071	0.51193935
78	Retinol metabolism_Homo sapiens_hsa00830	0.47766020
79	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.46735836
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.46655249
81	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.44734425
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.44245634
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.43466601
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41649020
85	Wnt signaling pathway_Homo sapiens_hsa04310	0.41126291
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.40705227
87	RNA degradation_Homo sapiens_hsa03018	0.40002902
88	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.38411186
89	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.37226050
90	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.35019759
91	Propanoate metabolism_Homo sapiens_hsa00640	0.34072579
92	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.33761714
93	RNA polymerase_Homo sapiens_hsa03020	0.31786079
94	Arginine biosynthesis_Homo sapiens_hsa00220	0.30560743
95	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.30205135
96	Calcium signaling pathway_Homo sapiens_hsa04020	0.28470430
97	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.25312313
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.24991409
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.24770828
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.24420263

LAGE3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »