LALBA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pattern specification involved in kidney development (GO:0061004)9.06373366
2intestinal cholesterol absorption (GO:0030299)8.20185609
3fatty-acyl-CoA biosynthetic process (GO:0046949)8.02668883
4long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)7.87764873
5pyrimidine-containing compound transmembrane transport (GO:0072531)7.76447080
6thioester biosynthetic process (GO:0035384)7.76017591
7acyl-CoA biosynthetic process (GO:0071616)7.76017591
8regulation of vascular endothelial growth factor signaling pathway (GO:1900746)7.56302350
9alpha-linolenic acid metabolic process (GO:0036109)7.28869430
10regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)6.97501326
11regulation of sequestering of triglyceride (GO:0010889)6.89336075
12lactation (GO:0007595)6.82639755
13sterol catabolic process (GO:0016127)6.72583806
14cholesterol catabolic process (GO:0006707)6.72583806
15negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)6.62619441
16positive regulation of p38MAPK cascade (GO:1900745)6.44076105
17regulation of phospholipid biosynthetic process (GO:0071071)6.41003318
18phospholipid homeostasis (GO:0055091)6.35491836
19linoleic acid metabolic process (GO:0043651)6.19163078
20nucleoside transmembrane transport (GO:1901642)6.02942018
21long-chain fatty-acyl-CoA metabolic process (GO:0035336)6.02326788
22fatty acid transmembrane transport (GO:1902001)5.98882386
23carnitine shuttle (GO:0006853)5.92925523
24mammary gland epithelial cell differentiation (GO:0060644)5.89707080
25secretion by tissue (GO:0032941)5.75666990
26fatty-acyl-CoA metabolic process (GO:0035337)5.74683321
27intestinal absorption (GO:0050892)5.73907893
28ectoderm development (GO:0007398)5.58953981
29biotin metabolic process (GO:0006768)5.56633200
30ceramide catabolic process (GO:0046514)5.51265774
31negative regulation of protein kinase B signaling (GO:0051898)5.24448143
32mitochondrial calcium ion transport (GO:0006851)5.07331471
33acetyl-CoA metabolic process (GO:0006084)5.01889216
34nucleobase catabolic process (GO:0046113)4.99573730
35positive regulation of osteoblast proliferation (GO:0033690)4.98630352
36embryonic process involved in female pregnancy (GO:0060136)4.91059968
37segment specification (GO:0007379)4.86040590
38body fluid secretion (GO:0007589)4.82030584
39N-acetylneuraminate metabolic process (GO:0006054)4.81146037
40negative regulation of endothelial cell proliferation (GO:0001937)4.79063362
41tooth mineralization (GO:0034505)4.69668447
42triglyceride biosynthetic process (GO:0019432)4.59927411
43phagocytosis, recognition (GO:0006910)4.56060160
44regulation of p38MAPK cascade (GO:1900744)4.55337904
45nucleoside transport (GO:0015858)4.54841127
46folic acid transport (GO:0015884)4.54650018
47* oligosaccharide biosynthetic process (GO:0009312)4.46312731
48GDP-mannose metabolic process (GO:0019673)4.41800613
49acylglycerol biosynthetic process (GO:0046463)4.41264438
50neutral lipid biosynthetic process (GO:0046460)4.41264438
51regulation of apoptotic cell clearance (GO:2000425)4.40099541
52carnitine transmembrane transport (GO:1902603)4.39580823
53response to phenylpropanoid (GO:0080184)4.37931003
54O-glycan processing (GO:0016266)4.34658737
55coenzyme A biosynthetic process (GO:0015937)4.31843266
56regulation of apoptotic process involved in morphogenesis (GO:1902337)4.27070090
57regulation of triglyceride biosynthetic process (GO:0010866)4.20365958
58response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.16593709
59response to host immune response (GO:0052572)4.16593709
60regulation of toll-like receptor 4 signaling pathway (GO:0034143)4.08810901
61positive regulation of triglyceride metabolic process (GO:0090208)4.07407368
62Golgi transport vesicle coating (GO:0048200)4.06827418
63COPI coating of Golgi vesicle (GO:0048205)4.06827418
64regulation of triglyceride metabolic process (GO:0090207)4.05348487
65tricarboxylic acid metabolic process (GO:0072350)4.04187161
66CDP-diacylglycerol biosynthetic process (GO:0016024)4.04005637
67growth hormone receptor signaling pathway (GO:0060396)4.02571393
68long-chain fatty acid transport (GO:0015909)4.01678638
69amino-acid betaine transport (GO:0015838)4.01637904
70carnitine transport (GO:0015879)4.01637904
71lipid storage (GO:0019915)3.93775276
72positive regulation of reactive oxygen species metabolic process (GO:2000379)3.93059688
73positive regulation of macrophage cytokine production (GO:0060907)3.88696151
74low-density lipoprotein particle clearance (GO:0034383)3.88367379
75negative regulation of lipid catabolic process (GO:0050995)3.82752133
76glutathione biosynthetic process (GO:0006750)3.82397789
77negative regulation of epithelial cell differentiation (GO:0030857)3.80033133
78positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.78296549
79copper ion transport (GO:0006825)3.70472127
80nucleotide-sugar biosynthetic process (GO:0009226)3.70403493
81transcytosis (GO:0045056)3.70047155
82CDP-diacylglycerol metabolic process (GO:0046341)3.69987433
83response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.69936324
84response to host (GO:0075136)3.69936324
85response to host defenses (GO:0052200)3.69936324
86negative regulation of execution phase of apoptosis (GO:1900118)3.67314261
87fatty acid transport (GO:0015908)3.67292344
88zinc ion transport (GO:0006829)3.64310842
89regulation of vasculogenesis (GO:2001212)3.63751862
90positive regulation of toll-like receptor signaling pathway (GO:0034123)3.63629940
91nonribosomal peptide biosynthetic process (GO:0019184)3.61509372
92positive regulation of lipid storage (GO:0010884)3.60378496
93pentose-phosphate shunt (GO:0006098)3.60280868
94regulation of penile erection (GO:0060405)3.59493470
95intracellular lipid transport (GO:0032365)3.54859043
96regulation of clathrin-mediated endocytosis (GO:2000369)3.54721482
97regulation of macrophage cytokine production (GO:0010935)3.49291979
98acyl-CoA metabolic process (GO:0006637)3.48262896
99thioester metabolic process (GO:0035383)3.48262896
100negative regulation of fatty acid transport (GO:2000192)3.47778592
101regulation of execution phase of apoptosis (GO:1900117)3.47537107
102regulation of endothelial cell differentiation (GO:0045601)3.45600847
103heme transport (GO:0015886)3.44334890
104regulation of triglyceride catabolic process (GO:0010896)3.40476091
105cellular response to growth hormone stimulus (GO:0071378)3.39784202
106type B pancreatic cell proliferation (GO:0044342)3.37919424
107positive regulation of lipoprotein lipase activity (GO:0051006)3.37491424
108positive regulation of triglyceride lipase activity (GO:0061365)3.37491424
109sphingolipid catabolic process (GO:0030149)3.32093986
110purine nucleobase metabolic process (GO:0006144)3.31755802
111regulation of cholesterol storage (GO:0010885)3.29715129
112negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.29243830
113positive regulation of chemokine secretion (GO:0090197)3.28994566
114purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.28375214
115ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.28375214
116nucleoside bisphosphate biosynthetic process (GO:0033866)3.28375214
117coenzyme A metabolic process (GO:0015936)3.26999207
118branched-chain amino acid metabolic process (GO:0009081)3.26796832
119positive regulation of histone deacetylation (GO:0031065)3.26004425
120mitochondrion distribution (GO:0048311)3.25882944
121triglyceride catabolic process (GO:0019433)3.23905433
122temperature homeostasis (GO:0001659)3.23394510
123valine metabolic process (GO:0006573)3.22349882
124iron coordination entity transport (GO:1901678)3.21714210
125cellular response to vitamin D (GO:0071305)3.21052166
126triglyceride metabolic process (GO:0006641)3.20631453
127NADPH regeneration (GO:0006740)3.19475475
128angiogenesis involved in wound healing (GO:0060055)3.18420892
129branched-chain amino acid catabolic process (GO:0009083)3.16951262
130positive regulation of triglyceride biosynthetic process (GO:0010867)3.14251564
131regulation of fatty acid oxidation (GO:0046320)3.13210047
132sialylation (GO:0097503)3.12236524
133steroid catabolic process (GO:0006706)3.07594911
134proximal/distal pattern formation (GO:0009954)3.06105736
135positive regulation of tissue remodeling (GO:0034105)3.05197640
136positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.04727114
137acylglycerol metabolic process (GO:0006639)3.02633884
138regulation of lipid storage (GO:0010883)3.02107514
139urate metabolic process (GO:0046415)3.01781162
140neutral lipid metabolic process (GO:0006638)2.98576518
141acylglycerol catabolic process (GO:0046464)2.97487075
142neutral lipid catabolic process (GO:0046461)2.97487075
143membrane lipid catabolic process (GO:0046466)2.96132703
144regulation of chemokine secretion (GO:0090196)2.94075231
145galactose metabolic process (GO:0006012)2.89105131
146negative regulation of cell fate commitment (GO:0010454)2.88000328
147folic acid metabolic process (GO:0046655)2.87845752
148short-chain fatty acid metabolic process (GO:0046459)2.80095821
149detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.77585938
150acrosome assembly (GO:0001675)2.73582774
151regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.69986419
152nucleoside diphosphate biosynthetic process (GO:0009133)2.66855253
153peptide biosynthetic process (GO:0043043)2.59052390
154negative regulation of leukocyte migration (GO:0002686)2.56068200
155detection of molecule of bacterial origin (GO:0032490)2.53001492
156ether lipid metabolic process (GO:0046485)2.51851185
157digestive system process (GO:0022600)2.47095250
158one-carbon metabolic process (GO:0006730)2.46758507
159positive regulation of macrophage activation (GO:0043032)2.44498781
160citrulline biosynthetic process (GO:0019240)2.44473872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse7.15225945
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.09043529
3ESR1_21235772_ChIP-Seq_MCF-7_Human5.18572319
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.38181679
5ESR2_21235772_ChIP-Seq_MCF-7_Human4.20126032
6ZNF263_19887448_ChIP-Seq_K562_Human3.36921683
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.34691810
8CLOCK_20551151_ChIP-Seq_293T_Human3.34332475
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.24299216
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.06252540
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.05445456
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.82768227
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.75678185
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.50859799
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.47171632
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.38705923
17ESR1_15608294_ChIP-ChIP_MCF-7_Human2.27986636
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.18014120
19AR_21572438_ChIP-Seq_LNCaP_Human2.14113455
20SRY_22984422_ChIP-ChIP_TESTIS_Rat2.08539195
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08181146
22PPARA_22158963_ChIP-Seq_LIVER_Mouse2.07331299
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00616529
24SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.00585845
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98018206
26FLI1_21867929_ChIP-Seq_CD8_Mouse1.85300900
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.83102620
28ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.81869319
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.80216521
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.75214137
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75130859
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.70844532
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65189214
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.62032583
35SOX2_20726797_ChIP-Seq_SW620_Human1.61294237
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59020950
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.54810888
38RXR_22108803_ChIP-Seq_LS180_Human1.52723423
39CTCF_26484167_Chip-Seq_Bcells_Mouse1.49021362
40HTT_18923047_ChIP-ChIP_STHdh_Human1.44832919
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44784269
42ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.43728592
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.43344945
44PU.1_20513432_ChIP-Seq_Bcells_Mouse1.42717744
45RACK7_27058665_Chip-Seq_MCF-7_Human1.40782804
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32551748
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32015234
48GATA4_25053715_ChIP-Seq_YYC3_Human1.31723639
49RUNX1_27514584_Chip-Seq_MCF-7_Human1.30875527
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30146517
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29793630
52SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29668603
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24671145
54LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.24295468
55SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.24281039
56GATA1_22025678_ChIP-Seq_K562_Human1.23608350
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22209865
58EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20596160
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20298394
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.20227524
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18116672
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17223366
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.17142420
64RUNX1_27457419_Chip-Seq_LIVER_Mouse1.16878147
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15926922
66TBX20_22080862_ChIP-Seq_HEART_Mouse1.15814544
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.15814544
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09277668
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05944276
70* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05817981
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05771138
72GATA3_24758297_ChIP-Seq_MCF-7_Human1.05659230
73GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.05525424
74* KLF5_25053715_ChIP-Seq_YYC3_Human1.04971582
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04777735
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03520660
77ATF3_27146783_Chip-Seq_COLON_Human1.02255624
78PU1_27457419_Chip-Seq_LIVER_Mouse1.02011485
79AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01236443
80LXR_22292898_ChIP-Seq_THP-1_Human1.01100971
81LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99742277
82ELK3_25401928_ChIP-Seq_HUVEC_Human0.99195563
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99187372
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97589740
85EGR1_19374776_ChIP-ChIP_THP-1_Human0.97429165
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97392851
87SMC4_20622854_ChIP-Seq_HELA_Human0.96856408
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96418997
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95893632
90SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95863765
91GATA1_19941826_ChIP-Seq_K562_Human0.94573795
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93895861
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.93350585
94GATA2_21666600_ChIP-Seq_HMVEC_Human0.88443784
95FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88354447
96ERG_20517297_ChIP-Seq_VCAP_Human0.88118643
97CREB1_26743006_Chip-Seq_LNCaP_Human0.87925499
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86702759
99FOXA1_25552417_ChIP-Seq_VCAP_Human0.86683275
100TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86633562
101ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85876892
102STAT1_17558387_ChIP-Seq_HELA_Human0.85866397
103PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85676090
104SA1_27219007_Chip-Seq_ERYTHROID_Human0.85570563
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84723747
106CHD1_26751641_Chip-Seq_LNCaP_Human0.84546195
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84510954
108STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.84282319
109STAT3_18555785_Chip-Seq_ESCs_Mouse0.84046552
110GATA2_19941826_ChIP-Seq_K562_Human0.83762294
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83708194
112NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83684664
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83449125
114CJUN_26792858_Chip-Seq_BT549_Human0.83348603
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83197468
116* PU_27001747_Chip-Seq_BMDM_Mouse0.83124166
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82686646
118* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82504144
119P300_27058665_Chip-Seq_ZR-75-30cells_Human0.80269077
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80093961
121NANOG_18692474_ChIP-Seq_MEFs_Mouse0.80059459
122ZFP281_27345836_Chip-Seq_ESCs_Mouse0.79899467
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79849654
124KDM2B_26808549_Chip-Seq_K562_Human0.79559562
125NFYA_21822215_ChIP-Seq_K562_Human0.79430805
126FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79382903
127CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78414945
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78232572
129ETS1_22383799_ChIP-Seq_G1ME_Mouse0.78208653
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78129089
131CBX2_22325352_ChIP-Seq_293T-Rex_Human0.77937373
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77575930
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77017594
134POU5F1_16518401_ChIP-PET_MESCs_Mouse0.76669248
135CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76622386
136AHR_22903824_ChIP-Seq_MCF-7_Human0.76162594
137VDR_24763502_ChIP-Seq_THP-1_Human0.76109549
138SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.75126866
139SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74890256
140NANOG_21062744_ChIP-ChIP_HESCs_Human0.74837477
141FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.74325228
142* TP63_23658742_ChIP-Seq_EP156T_Human0.74183426
143NFIB_24661679_ChIP-Seq_LUNG_Mouse0.73615044
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.73516806
145TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.72980154
146VDR_21846776_ChIP-Seq_THP-1_Human0.72890108
147NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.72569959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.94303404
2MP0005083_abnormal_biliary_tract3.80337806
3MP0002254_reproductive_system_inflammat3.56816360
4MP0003303_peritoneal_inflammation3.29470619
5MP0003300_gastrointestinal_ulcer3.27164922
6MP0004130_abnormal_muscle_cell2.99980192
7* MP0000627_abnormal_mammary_gland2.91303919
8MP0004019_abnormal_vitamin_homeostasis2.84318839
9MP0001873_stomach_inflammation2.57379216
10MP0004147_increased_porphyrin_level2.42289670
11MP0003705_abnormal_hypodermis_morpholog2.39248077
12MP0003136_yellow_coat_color2.36400282
13MP0003011_delayed_dark_adaptation2.35693376
14MP0002796_impaired_skin_barrier2.02851715
15MP0005360_urolithiasis2.02806064
16MP0005085_abnormal_gallbladder_physiolo2.01032024
17* MP0001881_abnormal_mammary_gland11.5973412
18MP0004264_abnormal_extraembryonic_tissu1.93030074
19MP0005666_abnormal_adipose_tissue1.92009270
20MP0003718_maternal_effect1.87333999
21MP0005670_abnormal_white_adipose1.82705126
22MP0004043_abnormal_pH_regulation1.71326227
23MP0005645_abnormal_hypothalamus_physiol1.63267534
24MP0005410_abnormal_fertilization1.59181500
25MP0002118_abnormal_lipid_homeostasis1.53662193
26MP0001666_abnormal_nutrient_absorption1.51716127
27MP0010329_abnormal_lipoprotein_level1.42344565
28MP0005375_adipose_tissue_phenotype1.40003435
29MP0004185_abnormal_adipocyte_glucose1.38535104
30MP0005395_other_phenotype1.34624019
31MP0001664_abnormal_digestion1.31488787
32MP0002098_abnormal_vibrissa_morphology1.30906504
33MP0008438_abnormal_cutaneous_collagen1.27065548
34MP0004272_abnormal_basement_membrane1.26216927
35MP0008004_abnormal_stomach_pH1.23015828
36MP0000678_abnormal_parathyroid_gland1.22398310
37MP0002139_abnormal_hepatobiliary_system1.20309042
38MP0002009_preneoplasia1.10053674
39MP0005584_abnormal_enzyme/coenzyme_acti1.09150895
40MP0003566_abnormal_cell_adhesion1.07882495
41MP0001849_ear_inflammation1.07222729
42MP0005501_abnormal_skin_physiology1.05871025
43MP0000377_abnormal_hair_follicle1.05255032
44MP0009764_decreased_sensitivity_to1.03201432
45MP0002971_abnormal_brown_adipose1.00960669
46MP0009384_cardiac_valve_regurgitation0.96708435
47MP0001663_abnormal_digestive_system0.96161253
48MP0010352_gastrointestinal_tract_polyps0.94965419
49MP0002168_other_aberrant_phenotype0.94215847
50MP0010678_abnormal_skin_adnexa0.92901966
51MP0005076_abnormal_cell_differentiation0.92531374
52MP0005332_abnormal_amino_acid0.90798534
53MP0005334_abnormal_fat_pad0.90131803
54MP0000639_abnormal_adrenal_gland0.89236759
55MP0000490_abnormal_crypts_of0.89234614
56MP0000750_abnormal_muscle_regeneration0.89210318
57MP0005448_abnormal_energy_balance0.88715308
58MP0003045_fibrosis0.88095508
59MP0000609_abnormal_liver_physiology0.87964838
60MP0003936_abnormal_reproductive_system0.87481842
61MP0009278_abnormal_bone_marrow0.84458170
62MP0002970_abnormal_white_adipose0.83679756
63MP0009765_abnormal_xenobiotic_induced0.83121284
64MP0000013_abnormal_adipose_tissue0.83110709
65MP0005275_abnormal_skin_tensile0.82996020
66MP0003448_altered_tumor_morphology0.82708483
67MP0001879_abnormal_lymphatic_vessel0.81840280
68MP0008260_abnormal_autophagy0.81549550
69MP0005171_absent_coat_pigmentation0.81478687
70MP0001958_emphysema0.80649423
71MP0008770_decreased_survivor_rate0.79321394
72MP0002396_abnormal_hematopoietic_system0.78081405
73MP0005636_abnormal_mineral_homeostasis0.76602582
74MP0003075_altered_response_to0.76548772
75MP0005365_abnormal_bile_salt0.75687492
76MP0003690_abnormal_glial_cell0.75445982
77MP0002896_abnormal_bone_mineralization0.75416817
78MP0005381_digestive/alimentary_phenotyp0.74939649
79MP0001984_abnormal_olfaction0.74759931
80MP0005535_abnormal_body_temperature0.74390724
81MP0001727_abnormal_embryo_implantation0.73443891
82MP0009643_abnormal_urine_homeostasis0.69700686
83MP0005220_abnormal_exocrine_pancreas0.67636712
84MP0000003_abnormal_adipose_tissue0.67605446
85MP0000613_abnormal_salivary_gland0.67444209
86MP0005023_abnormal_wound_healing0.67419569
87MP0004924_abnormal_behavior0.65628069
88MP0005386_behavior/neurological_phenoty0.65628069
89MP0004947_skin_inflammation0.64352387
90MP0002078_abnormal_glucose_homeostasis0.63560287
91MP0003172_abnormal_lysosome_physiology0.62226981
92MP0003656_abnormal_erythrocyte_physiolo0.61411267
93MP0003950_abnormal_plasma_membrane0.59927885
94MP0003453_abnormal_keratinocyte_physiol0.59903851
95MP0001216_abnormal_epidermal_layer0.59421461
96MP0005452_abnormal_adipose_tissue0.59275970
97MP0001851_eye_inflammation0.57917766
98MP0002282_abnormal_trachea_morphology0.57801806
99MP0005164_abnormal_response_to0.57660561
100MP0003959_abnormal_lean_body0.57472721
101MP0000858_altered_metastatic_potential0.56962200
102MP0003948_abnormal_gas_homeostasis0.54536019
103MP0001765_abnormal_ion_homeostasis0.54354582
104MP0002148_abnormal_hypersensitivity_rea0.54335722
105MP0005165_increased_susceptibility_to0.52796019
106MP0004858_abnormal_nervous_system0.52297925
107MP0006054_spinal_hemorrhage0.52281981
108MP0001177_atelectasis0.51600595
109MP0009379_abnormal_foot_pigmentation0.51320245
110MP0005319_abnormal_enzyme/_coenzyme0.51071562
111MP0005408_hypopigmentation0.50017686
112MP0009763_increased_sensitivity_to0.48951233
113MP0002060_abnormal_skin_morphology0.48916238
114MP0003953_abnormal_hormone_level0.48770902
115MP0002332_abnormal_exercise_endurance0.47559474
116MP0009931_abnormal_skin_appearance0.46068866
117MP0000920_abnormal_myelination0.46048630
118MP0001533_abnormal_skeleton_physiology0.45231528
119MP0000759_abnormal_skeletal_muscle0.45101285
120MP0001544_abnormal_cardiovascular_syste0.44178293
121MP0005385_cardiovascular_system_phenoty0.44178293
122MP0009642_abnormal_blood_homeostasis0.41966495
123MP0002135_abnormal_kidney_morphology0.41738624
124MP0005058_abnormal_lysosome_morphology0.41275990
125MP0003195_calcinosis0.40346679
126MP0005388_respiratory_system_phenotype0.40273087
127MP0002133_abnormal_respiratory_system0.40273087
128MP0010771_integument_phenotype0.39631097
129MP0009785_altered_susceptibility_to0.38189301
130MP0000371_diluted_coat_color0.37987222
131MP0001756_abnormal_urination0.35256271
132MP0004782_abnormal_surfactant_physiolog0.34176196
133MP0008789_abnormal_olfactory_epithelium0.32230211
134MP0008874_decreased_physiological_sensi0.32222345
135MP0000343_altered_response_to0.29529850
136MP0001853_heart_inflammation0.29296432
137MP0002419_abnormal_innate_immunity0.29107813
138MP0001542_abnormal_bone_strength0.28522920
139MP0005499_abnormal_olfactory_system0.27247018
140MP0005394_taste/olfaction_phenotype0.27247018
141MP0001764_abnormal_homeostasis0.26381096
142MP0002089_abnormal_postnatal_growth/wei0.26222392
143MP0002693_abnormal_pancreas_physiology0.24861829
144MP0000537_abnormal_urethra_morphology0.24584485
145MP0005451_abnormal_body_composition0.23745351
146MP0003638_abnormal_response/metabolism_0.23739741
147MP0000598_abnormal_liver_morphology0.22466570

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)6.82754406
2Decreased circulating renin level (HP:0003351)6.66287644
3Abnormality of purine metabolism (HP:0004352)6.30385523
4Gout (HP:0001997)5.61953506
5Axonal loss (HP:0003447)5.38910656
6Amelogenesis imperfecta (HP:0000705)5.33667701
7Congenital ichthyosiform erythroderma (HP:0007431)5.08856431
8Thin bony cortex (HP:0002753)4.53841042
9Hypokalemic alkalosis (HP:0001949)4.45643414
10Epidermoid cyst (HP:0200040)4.33714094
11Overgrowth (HP:0001548)3.96467521
12Hyperkalemia (HP:0002153)3.94106545
13Hyperlipoproteinemia (HP:0010980)3.93744426
14Abnormality of nucleobase metabolism (HP:0010932)3.83827584
15Hydronephrosis (HP:0000126)3.83346208
16Pili torti (HP:0003777)3.81267223
17Myocardial infarction (HP:0001658)3.79708254
18Chronic bronchitis (HP:0004469)3.78467718
19Nephritis (HP:0000123)3.75563360
20Hyperaldosteronism (HP:0000859)3.68546660
21Abnormality of calcium-phosphate metabolism (HP:0100530)3.60415194
22Tubulointerstitial nephritis (HP:0001970)3.60134668
23Right ventricular cardiomyopathy (HP:0011663)3.57512807
24Stridor (HP:0010307)3.47802475
25Skin nodule (HP:0200036)3.42293201
26Enlarged epiphyses (HP:0010580)3.40731204
27Metaphyseal dysplasia (HP:0100255)3.36091975
28Protuberant abdomen (HP:0001538)3.35615543
29Abnormality of renal excretion (HP:0011036)3.31356919
30Curly hair (HP:0002212)3.29490524
31Ectropion (HP:0000656)3.27140544
32Subcapsular cataract (HP:0000523)3.26243044
33Hypotension (HP:0002615)3.18813840
34Aortic aneurysm (HP:0004942)3.14140695
35Neurodegeneration (HP:0002180)3.11318897
36Abnormality of renin-angiotensin system (HP:0000847)3.08644111
37Xanthomatosis (HP:0000991)3.07324418
38Metaphyseal irregularity (HP:0003025)3.04978814
39Hyponatremia (HP:0002902)3.03039212
40Tubulointerstitial fibrosis (HP:0005576)3.01839521
41Glomerulosclerosis (HP:0000096)3.00680858
42Abnormal tarsal ossification (HP:0008369)2.88464972
43Abnormality of renal resorption (HP:0011038)2.87300559
44Turricephaly (HP:0000262)2.84616324
45Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.81643722
46Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.81620634
47Cerebral aneurysm (HP:0004944)2.79782043
48Abnormality of chloride homeostasis (HP:0011422)2.78529701
49Flat acetabular roof (HP:0003180)2.75473717
50Bone cyst (HP:0012062)2.71118200
51Abnormal auditory evoked potentials (HP:0006958)2.69258487
52Increased purine levels (HP:0004368)2.69171129
53Hyperuricemia (HP:0002149)2.69171129
54Nausea (HP:0002018)2.69167322
55Delayed epiphyseal ossification (HP:0002663)2.57488812
56Epiphyseal dysplasia (HP:0002656)2.57284926
57Ketoacidosis (HP:0001993)2.52146267
58Aortic dissection (HP:0002647)2.50435355
59Renal salt wasting (HP:0000127)2.49377305
60Abnormality of sodium homeostasis (HP:0010931)2.46233249
61Abnormality of transition element cation homeostasis (HP:0011030)2.46112852
62Hypoplasia of the iris (HP:0007676)2.43716309
63Atrophic scars (HP:0001075)2.41223929
64Premature skin wrinkling (HP:0100678)2.40679747
65Loss of speech (HP:0002371)2.38167349
66Vacuolated lymphocytes (HP:0001922)2.38014006
67Abdominal distention (HP:0003270)2.37770853
68Enlarged penis (HP:0000040)2.37494825
69Hyperglycinemia (HP:0002154)2.36493285
70Nephrolithiasis (HP:0000787)2.34905337
71Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.31504067
72Hyperglycinuria (HP:0003108)2.31497196
73Intrahepatic cholestasis (HP:0001406)2.30236691
74Adrenal overactivity (HP:0002717)2.28859503
75Tubular atrophy (HP:0000092)2.28359433
76Abnormal hair laboratory examination (HP:0003328)2.28297592
77Rickets (HP:0002748)2.24110119
78Aneurysm (HP:0002617)2.23590849
79Widely patent fontanelles and sutures (HP:0004492)2.20394464
80Alkalosis (HP:0001948)2.19418645
81Deep venous thrombosis (HP:0002625)2.19052349
82Hypoplasia of dental enamel (HP:0006297)2.17462588
83Hepatosplenomegaly (HP:0001433)2.15472040
84Polar cataract (HP:0010696)2.15016113
85Glomerulonephritis (HP:0000099)2.13423886
86Cortical dysplasia (HP:0002539)2.13130250
87Asymmetry of the thorax (HP:0001555)2.12049947
88Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.10625316
89Wide cranial sutures (HP:0010537)2.10384162
90Increased serum ferritin (HP:0003281)2.09557813
91Abnormal epiphyseal ossification (HP:0010656)2.08727992
92Abnormality of vision evoked potentials (HP:0000649)2.07281052
93Abnormality of glycolipid metabolism (HP:0010969)2.07215245
94Abnormality of liposaccharide metabolism (HP:0010968)2.07215245
95Abnormality of glycosphingolipid metabolism (HP:0004343)2.07215245
96Osteolytic defects of the phalanges of the hand (HP:0009771)2.06992894
97Osteolytic defects of the hand bones (HP:0009699)2.06992894
98Buphthalmos (HP:0000557)2.06931930
99Hypercholesterolemia (HP:0003124)2.06691365
100Optic neuritis (HP:0100653)2.06583000
101Retrobulbar optic neuritis (HP:0100654)2.06583000
102Metabolic acidosis (HP:0001942)2.05144786
103Biliary tract neoplasm (HP:0100574)2.05019302
104Elevated alkaline phosphatase (HP:0003155)2.04112176
105Arterial tortuosity (HP:0005116)2.01735742
106Azoospermia (HP:0000027)2.01384839
107Abnormality of dental color (HP:0011073)2.01092119
108Abnormality of the anterior chamber (HP:0000593)2.00598773
109Abnormality of the periventricular white matter (HP:0002518)2.00584380
110Milia (HP:0001056)1.97500393
111Postnatal microcephaly (HP:0005484)1.97296339
112Premature loss of primary teeth (HP:0006323)1.93966212
113Ketosis (HP:0001946)1.92348530
114Orchitis (HP:0100796)1.92190192
115Hypophosphatemia (HP:0002148)1.91087320
116Hypokalemia (HP:0002900)1.90930882
117Abnormality of the costochondral junction (HP:0000919)1.90522806
118Poor eye contact (HP:0000817)1.90412919
119Dysostosis multiplex (HP:0000943)1.87972880
120Long toe (HP:0010511)1.87247724
121Increased cerebral lipofuscin (HP:0011813)1.86620843
122Tetraparesis (HP:0002273)1.85133138
123Asymmetric septal hypertrophy (HP:0001670)1.84361291
124Spastic tetraparesis (HP:0001285)1.83472491
125Peripheral hypomyelination (HP:0007182)1.83163930
126Vascular tortuosity (HP:0004948)1.82708604
127Abnormality of the dental pulp (HP:0006479)1.82581475
128Paraparesis (HP:0002385)1.82266403
129Conjunctival hamartoma (HP:0100780)1.82198512
130Abnormal enzyme/coenzyme activity (HP:0012379)1.81487207
131Pustule (HP:0200039)1.79474520
132Abnormality of serine family amino acid metabolism (HP:0010894)1.78501700
133Abnormality of glycine metabolism (HP:0010895)1.78501700
134Epiphyseal stippling (HP:0010655)1.76773004
135Pancreatitis (HP:0001733)1.76214400
136Autoamputation (HP:0001218)1.76162242
137Cortical visual impairment (HP:0100704)1.75976248
138Fatigue (HP:0012378)1.75807323
139Peripheral demyelination (HP:0011096)1.75569456
140Back pain (HP:0003418)1.75236722
141Abnormality of alkaline phosphatase activity (HP:0004379)1.74799535
142Abnormality of iron homeostasis (HP:0011031)1.74432455
143Symptomatic seizures (HP:0011145)1.74152398
144Abnormality of the intrinsic pathway (HP:0010989)1.73330647
145Onycholysis (HP:0001806)1.73071103
146Striae distensae (HP:0001065)1.72952385
147Esophageal varix (HP:0002040)1.72264328
148Hyperparathyroidism (HP:0000843)1.70951609
149Cardiovascular calcification (HP:0011915)1.69790813
150Ankle contracture (HP:0006466)1.69683229
151Congenital glaucoma (HP:0001087)1.69631184
152Abnormality of glycolysis (HP:0004366)1.68657130
153Increased serum pyruvate (HP:0003542)1.68657130
154Vascular calcification (HP:0004934)1.68409545
155Abnormality of fatty-acid metabolism (HP:0004359)1.67431926
156Primary adrenal insufficiency (HP:0008207)1.67266946
157Hemorrhage of the eye (HP:0011885)1.65633395
158Abnormality of aromatic amino acid family metabolism (HP:0004338)1.63941402
159Flat occiput (HP:0005469)1.63050019
160Opisthotonus (HP:0002179)1.63038623
161Systemic lupus erythematosus (HP:0002725)1.62839983
162Abnormality of the renal cortex (HP:0011035)1.61870075
163Genu varum (HP:0002970)1.60053394
164Reduced antithrombin III activity (HP:0001976)1.59985964
165Tubulointerstitial abnormality (HP:0001969)1.55471470
166Dehydration (HP:0001944)1.54864121
167Rough bone trabeculation (HP:0100670)1.50766049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK16.02418000
2CAMK1D5.36831551
3PKN24.99729652
4CAMK1G4.24968349
5TRIB33.96855140
6EEF2K3.33939814
7ERN12.94978772
8ICK2.87649659
9NME22.86346920
10MAP2K62.76523419
11ARAF2.47507662
12PDK42.43059737
13PDK32.43059737
14TESK12.22380250
15PTK62.21951224
16MATK2.19316725
17PIK3CA2.17016822
18BCKDK1.96383100
19RIPK11.88202122
20PDK21.84074715
21EPHB11.79696506
22PDGFRB1.77627011
23MAPKAPK31.65459016
24TGFBR21.64897844
25MAP3K91.64244879
26BMPR21.61618521
27ZAP701.59647016
28IRAK11.54920566
29RET1.51080991
30EPHA31.48962972
31LATS11.40341004
32DAPK21.36942782
33PRKAA21.35469436
34MOS1.32782038
35STK391.26082559
36BRAF1.25449500
37MAP3K131.24170747
38MAP3K71.22475898
39LRRK21.19918300
40STK381.14342656
41WNK41.06688146
42FER1.04702357
43BMX1.02396252
44MAP3K61.02385352
45NLK1.02038033
46STK161.00549820
47TESK20.94562596
48DDR20.91096337
49RPS6KB20.90987910
50CHUK0.89123383
51RIPK40.89109095
52PINK10.85894524
53TRPM70.84004076
54CSNK2A20.76705962
55STK38L0.74147130
56CAMK2D0.70913931
57SGK30.70666563
58LIMK10.70578812
59IRAK40.70395741
60PTK20.68810796
61MAPK120.68739499
62FGFR40.65549578
63MAPKAPK50.64745031
64IRAK20.64713092
65MAP3K20.63386724
66FRK0.63206694
67CAMK2G0.62780443
68TBK10.61570208
69CAMK10.61483367
70PRKCD0.61351459
71PRKAA10.61240930
72JAK20.60135759
73GRK70.59702844
74GSK3A0.59153474
75CAMK2B0.56346893
76TAOK20.54981212
77MAP2K20.52554152
78PDGFRA0.52441394
79TYRO30.52288536
80FLT30.52065891
81TAOK10.51634984
82IGF1R0.50771033
83PRKCG0.50393013
84JAK10.50228159
85MYLK0.49610443
86MET0.49033626
87JAK30.47020780
88IKBKE0.45094431
89RPS6KA20.44504346
90TAOK30.43124685
91EIF2AK10.42848860
92SGK20.40584158
93MTOR0.40357578
94TYK20.39764816
95EPHA20.38464458
96PDPK10.38090268
97EIF2AK20.37793593
98CSF1R0.37418926
99TIE10.37269208
100ERBB20.37222310
101NEK60.36541507
102FGR0.36414350
103PRKD10.36412443
104CAMKK10.35677830
105CSNK1A10.35282790
106PDK10.34813718
107EGFR0.34055876
108TTN0.32900091
109KSR20.32587841
110PAK20.31922425
111MAPK110.31885538
112PAK40.31335816
113PTK2B0.29834902
114MAP2K10.29647898
115EIF2AK30.29280440
116DYRK20.29105322
117MAP3K30.25973234
118MAP3K10.25875181
119IRAK30.25545455
120LYN0.25499856
121DAPK30.25449515
122SRC0.25396980
123PRKCZ0.25083297
124RAF10.24804651
125LMTK20.24733906
126STK30.23518802
127NEK90.22780975
128FGFR30.21645651
129WNK10.21128508
130CDK60.20781483
131ILK0.20635184
132CDK90.20480348
133PIK3CG0.20392572
134RPS6KB10.20306521
135SGK2230.20194019
136SGK4940.20194019
137LATS20.19497438
138SCYL20.19312180
139PIM10.17640272
140GRK60.15857800
141FGFR10.13708483
142INSR0.12994128
143CSK0.12533483
144BTK0.10902166

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000619.48390423
2Caffeine metabolism_Homo sapiens_hsa002328.86161016
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.91825572
4Fatty acid metabolism_Homo sapiens_hsa012122.60251133
5Propanoate metabolism_Homo sapiens_hsa006402.33311552
6Pyruvate metabolism_Homo sapiens_hsa006202.19548071
7Prolactin signaling pathway_Homo sapiens_hsa049171.93581045
8PPAR signaling pathway_Homo sapiens_hsa033201.78896434
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67182644
10Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.54581518
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53968766
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.51961188
13Steroid biosynthesis_Homo sapiens_hsa001001.19810562
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13189360
15N-Glycan biosynthesis_Homo sapiens_hsa005101.12027590
16Fatty acid degradation_Homo sapiens_hsa000711.07534282
17Fatty acid elongation_Homo sapiens_hsa000621.04031830
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97092060
19Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96510659
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92313084
21Adipocytokine signaling pathway_Homo sapiens_hsa049200.89941418
22Carbon metabolism_Homo sapiens_hsa012000.89430602
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87592353
24* Galactose metabolism_Homo sapiens_hsa000520.84939920
25AMPK signaling pathway_Homo sapiens_hsa041520.82862674
26Insulin resistance_Homo sapiens_hsa049310.82608093
27Fat digestion and absorption_Homo sapiens_hsa049750.77934050
28Protein export_Homo sapiens_hsa030600.77615740
29Pentose phosphate pathway_Homo sapiens_hsa000300.73776392
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73703939
31Drug metabolism - other enzymes_Homo sapiens_hsa009830.72585167
32Peroxisome_Homo sapiens_hsa041460.72557646
33Sulfur relay system_Homo sapiens_hsa041220.71037300
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69199176
35Glycerolipid metabolism_Homo sapiens_hsa005610.63634065
36Histidine metabolism_Homo sapiens_hsa003400.62385022
37beta-Alanine metabolism_Homo sapiens_hsa004100.61841602
38Pancreatic cancer_Homo sapiens_hsa052120.59528839
39Central carbon metabolism in cancer_Homo sapiens_hsa052300.57997985
40Amoebiasis_Homo sapiens_hsa051460.52505608
41Primary bile acid biosynthesis_Homo sapiens_hsa001200.52215550
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51677663
43Folate biosynthesis_Homo sapiens_hsa007900.49650314
44Insulin signaling pathway_Homo sapiens_hsa049100.49494333
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49454930
46Arginine biosynthesis_Homo sapiens_hsa002200.46971909
47Bladder cancer_Homo sapiens_hsa052190.46768405
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45432843
49Biosynthesis of amino acids_Homo sapiens_hsa012300.44849376
50Vibrio cholerae infection_Homo sapiens_hsa051100.44804032
51Collecting duct acid secretion_Homo sapiens_hsa049660.44726460
52ECM-receptor interaction_Homo sapiens_hsa045120.42156459
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41413121
54mTOR signaling pathway_Homo sapiens_hsa041500.41105273
55Fructose and mannose metabolism_Homo sapiens_hsa000510.41089288
56Ether lipid metabolism_Homo sapiens_hsa005650.40773966
57Toxoplasmosis_Homo sapiens_hsa051450.40060927
58Glucagon signaling pathway_Homo sapiens_hsa049220.39241009
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39117074
60Acute myeloid leukemia_Homo sapiens_hsa052210.38472058
61Chronic myeloid leukemia_Homo sapiens_hsa052200.37974923
62Butanoate metabolism_Homo sapiens_hsa006500.36978303
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36440420
64Starch and sucrose metabolism_Homo sapiens_hsa005000.36322189
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35652418
66HIF-1 signaling pathway_Homo sapiens_hsa040660.35399270
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35271529
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.35125448
69Gastric acid secretion_Homo sapiens_hsa049710.33824905
70Focal adhesion_Homo sapiens_hsa045100.33348678
71Rheumatoid arthritis_Homo sapiens_hsa053230.33240134
72Vitamin digestion and absorption_Homo sapiens_hsa049770.32853563
73Hepatitis C_Homo sapiens_hsa051600.32753740
74Pancreatic secretion_Homo sapiens_hsa049720.31814268
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30686722
76Mineral absorption_Homo sapiens_hsa049780.30098285
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29902211
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29601646
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29413668
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29022719
81Arginine and proline metabolism_Homo sapiens_hsa003300.28415277
82Tight junction_Homo sapiens_hsa045300.28133955
83Lysosome_Homo sapiens_hsa041420.27546461
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27200786
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27103550
86Sulfur metabolism_Homo sapiens_hsa009200.27027762
87Renal cell carcinoma_Homo sapiens_hsa052110.26766299
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26745735
89VEGF signaling pathway_Homo sapiens_hsa043700.26719172
90Endocytosis_Homo sapiens_hsa041440.25964063
91Endometrial cancer_Homo sapiens_hsa052130.25865883
92Adherens junction_Homo sapiens_hsa045200.25202538
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24254747
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24253279
95Purine metabolism_Homo sapiens_hsa002300.24024752
96Bile secretion_Homo sapiens_hsa049760.23142919
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23104516
98Small cell lung cancer_Homo sapiens_hsa052220.22341932
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.21372206
100Pertussis_Homo sapiens_hsa051330.21248831
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20685875
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.20503035
103Proteoglycans in cancer_Homo sapiens_hsa052050.20488677
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.19122199
105Phagosome_Homo sapiens_hsa041450.18852897
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18510771
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18103787
108* Metabolic pathways_Homo sapiens_hsa011000.17682938
109Non-small cell lung cancer_Homo sapiens_hsa052230.17324797
110ErbB signaling pathway_Homo sapiens_hsa040120.16017290
111Colorectal cancer_Homo sapiens_hsa052100.15341401
112Glutathione metabolism_Homo sapiens_hsa004800.14605845
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.14134469
114Salivary secretion_Homo sapiens_hsa049700.12589708
115One carbon pool by folate_Homo sapiens_hsa006700.12530718
116Tuberculosis_Homo sapiens_hsa051520.12173986
117Linoleic acid metabolism_Homo sapiens_hsa005910.12048759
118Synaptic vesicle cycle_Homo sapiens_hsa047210.11539085
119Nitrogen metabolism_Homo sapiens_hsa009100.10297131
120Malaria_Homo sapiens_hsa051440.09717270
121Hepatitis B_Homo sapiens_hsa051610.09584771
122Renin secretion_Homo sapiens_hsa049240.09189653
123Legionellosis_Homo sapiens_hsa051340.08788061
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.06851953
125Salmonella infection_Homo sapiens_hsa051320.06692616
126Leishmaniasis_Homo sapiens_hsa051400.05570511
127Arachidonic acid metabolism_Homo sapiens_hsa005900.03709459
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.02659414
129Ovarian steroidogenesis_Homo sapiens_hsa049130.02463487
130Vitamin B6 metabolism_Homo sapiens_hsa007500.02395572
131Tryptophan metabolism_Homo sapiens_hsa003800.02010594
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.00048699
133Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0517698
134Cholinergic synapse_Homo sapiens_hsa04725-0.0376228
135Estrogen signaling pathway_Homo sapiens_hsa04915-0.0332161
136Staphylococcus aureus infection_Homo sapiens_hsa05150-0.0187687
137Cysteine and methionine metabolism_Homo sapiens_hsa00270-0.0149819
138GnRH signaling pathway_Homo sapiens_hsa04912-0.0130369

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