LAMA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1atrioventricular valve morphogenesis (GO:0003181)9.94137108
2endoderm formation (GO:0001706)9.32821158
3peptidyl-proline hydroxylation (GO:0019511)8.46100104
4cellular response to follicle-stimulating hormone stimulus (GO:0071372)8.38159653
5regulation of transforming growth factor beta2 production (GO:0032909)7.70989669
64-hydroxyproline metabolic process (GO:0019471)7.54380534
7seminiferous tubule development (GO:0072520)7.51931345
8epithelial cell fate commitment (GO:0072148)7.42144523
9hemidesmosome assembly (GO:0031581)7.02050223
10response to follicle-stimulating hormone (GO:0032354)6.99561427
11cardiac muscle adaptation (GO:0014887)6.97892522
12cardiac muscle hypertrophy in response to stress (GO:0014898)6.97892522
13muscle hypertrophy in response to stress (GO:0003299)6.97892522
14substrate adhesion-dependent cell spreading (GO:0034446)6.93857965
15protein hydroxylation (GO:0018126)6.82352033
16cardiac right ventricle morphogenesis (GO:0003215)6.66363255
17endoderm development (GO:0007492)6.32006019
18regulation of gene silencing by RNA (GO:0060966)6.30014211
19regulation of posttranscriptional gene silencing (GO:0060147)6.30014211
20regulation of gene silencing by miRNA (GO:0060964)6.30014211
21regulation of Wnt signaling pathway involved in heart development (GO:0003307)6.01229650
22homocysteine metabolic process (GO:0050667)5.96444590
23regulation of cardiac muscle cell contraction (GO:0086004)5.96040914
24atrial septum morphogenesis (GO:0060413)5.59266294
25signal transduction involved in regulation of gene expression (GO:0023019)5.46665176
26SMAD protein signal transduction (GO:0060395)5.38437894
27midgut development (GO:0007494)5.37469192
28notochord development (GO:0030903)5.33305096
29nuclear pore complex assembly (GO:0051292)5.23429255
30cardiac muscle hypertrophy (GO:0003300)5.18631402
31gastrulation with mouth forming second (GO:0001702)5.07768697
32ventricular septum development (GO:0003281)4.97981170
33striated muscle hypertrophy (GO:0014897)4.84165839
34endodermal cell differentiation (GO:0035987)4.71878301
35negative regulation of cell fate specification (GO:0009996)4.70523204
36cellular response to gonadotropin stimulus (GO:0071371)4.69692122
37regulation of actin filament-based movement (GO:1903115)4.57423059
38nuclear pore organization (GO:0006999)4.56198355
39glucose 6-phosphate metabolic process (GO:0051156)4.51753563
40lung-associated mesenchyme development (GO:0060484)4.33422452
41dorsal/ventral axis specification (GO:0009950)4.27008798
42positive regulation of cardiac muscle cell proliferation (GO:0060045)4.25361482
43muscle hypertrophy (GO:0014896)4.23154233
44positive regulation of protein kinase C signaling (GO:0090037)4.21006956
45glomerular basement membrane development (GO:0032836)4.19366499
46pre-miRNA processing (GO:0031054)3.99968799
47embryonic digestive tract morphogenesis (GO:0048557)3.97164600
48formation of primary germ layer (GO:0001704)3.96995511
49organ formation (GO:0048645)3.95458964
50digestive tract morphogenesis (GO:0048546)3.80980306
51positive regulation of cardiac muscle tissue growth (GO:0055023)3.80136093
52cardiac septum morphogenesis (GO:0060411)3.79075605
53dendritic spine morphogenesis (GO:0060997)3.77849081
54regulation of centriole replication (GO:0046599)3.77321217
55pore complex assembly (GO:0046931)3.75468026
56response to gonadotropin (GO:0034698)3.74922084
57negative regulation of hormone biosynthetic process (GO:0032353)3.72915371
58regulation of hippo signaling (GO:0035330)3.67126817
59striated muscle adaptation (GO:0014888)3.57276508
60cardiac septum development (GO:0003279)3.52600971
61protein retention in ER lumen (GO:0006621)3.49498082
62maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.48509310
63lung epithelium development (GO:0060428)3.44979187
64mesenchyme development (GO:0060485)3.43206024
65male genitalia development (GO:0030539)3.41869113
66positive regulation vascular endothelial growth factor production (GO:0010575)3.40545414
67renal system development (GO:0072001)3.40042507
68positive regulation of BMP signaling pathway (GO:0030513)3.39968925
69heart valve morphogenesis (GO:0003179)3.39037301
70positive regulation of heart growth (GO:0060421)3.33091866
71mitotic sister chromatid cohesion (GO:0007064)3.33080279
72L-alpha-amino acid transmembrane transport (GO:1902475)3.31269193
73ventricular septum morphogenesis (GO:0060412)3.26023456
74positive regulation of developmental pigmentation (GO:0048087)3.20742110
75* polarized epithelial cell differentiation (GO:0030859)3.20397988
76cell-substrate junction assembly (GO:0007044)3.18182009
77nodal signaling pathway (GO:0038092)3.15621635
78negative regulation of cell fate commitment (GO:0010454)3.12323036
79regulation of cardiac muscle cell proliferation (GO:0060043)3.10148257
80paraxial mesoderm development (GO:0048339)3.09997458
81regulation of cell fate specification (GO:0042659)3.07806653
82embryo implantation (GO:0007566)3.06834952
83embryonic process involved in female pregnancy (GO:0060136)3.06069066
84mRNA transcription from RNA polymerase II promoter (GO:0042789)3.03986364
85bundle of His cell to Purkinje myocyte communication (GO:0086069)3.03651556
86regulation of centrosome cycle (GO:0046605)3.03335314
87urogenital system development (GO:0001655)3.02479952
88positive regulation of stem cell differentiation (GO:2000738)3.02329424
89protein localization to cell surface (GO:0034394)3.01198854
90genitalia morphogenesis (GO:0035112)3.00113014
91regulation of centrosome duplication (GO:0010824)2.99581172
92regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.99449211
93negative regulation of hormone metabolic process (GO:0032351)2.98257136
94regulation of glucocorticoid metabolic process (GO:0031943)2.96224719
95convergent extension (GO:0060026)2.95589201
96negative regulation of autophagy (GO:0010507)2.94837390
97DNA unwinding involved in DNA replication (GO:0006268)2.93571260
98heterochromatin organization (GO:0070828)2.93012610
99glutamine metabolic process (GO:0006541)2.93008818
100reproductive system development (GO:0061458)2.88664058
101cardiac muscle tissue development (GO:0048738)2.85896917
102sister chromatid segregation (GO:0000819)2.85586825
103cell surface receptor signaling pathway involved in heart development (GO:0061311)2.84217773
104non-recombinational repair (GO:0000726)2.83294124
105double-strand break repair via nonhomologous end joining (GO:0006303)2.83294124
106citrulline biosynthetic process (GO:0019240)2.81641132
107positive regulation of cardiac muscle tissue development (GO:0055025)2.81618275
108mitotic chromosome condensation (GO:0007076)2.81575864
109hippo signaling (GO:0035329)2.81228054
110pericardium development (GO:0060039)2.81180266
111urea cycle (GO:0000050)2.80476622
112cell migration involved in gastrulation (GO:0042074)2.79552309
113mitotic sister chromatid segregation (GO:0000070)2.79042423
114DNA replication checkpoint (GO:0000076)2.76086462
115cardiac ventricle morphogenesis (GO:0003208)2.76037233
116gastrulation (GO:0007369)2.75807407
117muscle adaptation (GO:0043500)2.75758143
118somite development (GO:0061053)2.74931466
119regulation of vascular endothelial growth factor production (GO:0010574)2.72891404
120lateral sprouting from an epithelium (GO:0060601)2.72726339
121gap junction assembly (GO:0016264)2.72618226
122regulation of transforming growth factor beta1 production (GO:0032908)2.71718525
123cell morphogenesis involved in differentiation (GO:0000904)2.71355050
124positive regulation of SMAD protein import into nucleus (GO:0060391)2.71036436
125negative regulation of stem cell proliferation (GO:2000647)2.69365462
126regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.68171433
127prenylation (GO:0097354)2.66574939
128protein prenylation (GO:0018342)2.66574939
129hepatocyte differentiation (GO:0070365)2.65784309
130regulation of mesoderm development (GO:2000380)2.65626584
131regulation of pigment cell differentiation (GO:0050932)2.65537502
132regulation of steroid hormone biosynthetic process (GO:0090030)2.65535208
133endothelial cell proliferation (GO:0001935)2.62592490
134regulation of non-canonical Wnt signaling pathway (GO:2000050)2.62482288
135trophectodermal cell differentiation (GO:0001829)2.60238031
136protein localization to kinetochore (GO:0034501)2.59719505
137regulation of transforming growth factor beta production (GO:0071634)2.58721445
138regulation of cardiac muscle tissue growth (GO:0055021)2.58698576
139adrenal gland development (GO:0030325)2.58215298
140mesenchymal cell differentiation (GO:0048762)2.57692405
141negative regulation of protein activation cascade (GO:2000258)2.56793026
142folic acid-containing compound biosynthetic process (GO:0009396)2.52984745
143mesenchymal cell proliferation (GO:0010463)2.52595446
144citrulline metabolic process (GO:0000052)2.52394201
145embryonic heart tube morphogenesis (GO:0003143)2.52346141
146negative regulation of keratinocyte proliferation (GO:0010839)2.51173675
147positive regulation of DNA-dependent DNA replication (GO:2000105)2.50691151
148response to BMP (GO:0071772)2.49483388
149cellular response to BMP stimulus (GO:0071773)2.49483388
150embryonic axis specification (GO:0000578)2.48265822
151chromatin remodeling at centromere (GO:0031055)2.48076429
152urea metabolic process (GO:0019627)2.46754458
153DNA duplex unwinding (GO:0032508)2.46345306
154somatic diversification of immune receptors via somatic mutation (GO:0002566)2.45446550
155somatic hypermutation of immunoglobulin genes (GO:0016446)2.45446550
156kinetochore organization (GO:0051383)2.44332692
157DNA geometric change (GO:0032392)2.43377921
158embryonic pattern specification (GO:0009880)2.41371638
159planar cell polarity pathway involved in neural tube closure (GO:0090179)2.38712420
160protein localization to chromosome, centromeric region (GO:0071459)2.38241793
161mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.37958492
162DNA strand elongation involved in DNA replication (GO:0006271)2.37364394
163CENP-A containing nucleosome assembly (GO:0034080)2.36761432
164DNA replication initiation (GO:0006270)2.36519525
165genitalia development (GO:0048806)2.36295243
166mitotic nuclear envelope disassembly (GO:0007077)2.33418733
167meiotic chromosome segregation (GO:0045132)2.31096542
168limb bud formation (GO:0060174)2.30378841
169negative regulation of complement activation (GO:0045916)2.29246444
170glomerular visceral epithelial cell development (GO:0072015)2.28239766
171L-serine metabolic process (GO:0006563)2.28159849
172anterior/posterior axis specification, embryo (GO:0008595)2.27636442
173response to food (GO:0032094)2.25984714
174DNA strand renaturation (GO:0000733)2.24069618
175DNA strand elongation (GO:0022616)2.23286604
176organ growth (GO:0035265)2.21920328
177regulation of cardioblast differentiation (GO:0051890)11.0729317
178endocardial cushion development (GO:0003197)10.4861605
179embryonic foregut morphogenesis (GO:0048617)10.4710697
180basement membrane organization (GO:0071711)10.1619181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.93460706
2* SALL4_18804426_ChIP-ChIP_XEN_Mouse5.29078329
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.69636685
4E2F7_22180533_ChIP-Seq_HELA_Human4.51900903
5HIF1A_21447827_ChIP-Seq_MCF-7_Human3.65582311
6AR_21909140_ChIP-Seq_LNCAP_Human3.45421519
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.36594556
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84418647
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.77265774
10* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.44083966
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.41007085
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.40136921
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.40045276
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.33509503
15CLOCK_20551151_ChIP-Seq_293T_Human2.23221845
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20744089
17* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.16420723
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.13821423
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.13821423
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.13821423
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.10785061
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.07582714
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04813373
24* SOX17_20123909_ChIP-Seq_XEN_Mouse2.04386061
25* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.03212545
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.93453441
27FUS_26573619_Chip-Seq_HEK293_Human1.90987095
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.83980469
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.83779374
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.77152273
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.76034569
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.74873586
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72007177
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.71274699
35ZFP281_27345836_Chip-Seq_ESCs_Mouse1.71131356
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.69869171
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.69499470
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68048674
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.67811410
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.64797418
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62687604
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.60755934
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56588904
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56135848
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55997873
46* UBF1/2_26484160_Chip-Seq_HMECs_Human1.55608008
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.54867947
48KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53679829
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53454375
50NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.52897761
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.52553872
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52514964
53ATF3_27146783_Chip-Seq_COLON_Human1.49798668
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49336772
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49063502
56ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.49029939
57EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.47313852
58* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47090618
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.46818647
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46680184
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46533698
62* ZNF263_19887448_ChIP-Seq_K562_Human1.45317017
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45059566
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44323953
65* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.43406979
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.40416180
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39823021
68* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38493157
69RACK7_27058665_Chip-Seq_MCF-7_Human1.38430868
70TCF3_18692474_ChIP-Seq_MESCs_Mouse1.38274669
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37956952
72TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37239677
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36546593
74TP53_20018659_ChIP-ChIP_R1E_Mouse1.35206357
75* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35023647
76GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.34730107
77NFIB_24661679_ChIP-Seq_LUNG_Mouse1.33501658
78ELK1_19687146_ChIP-ChIP_HELA_Human1.33233448
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.32606111
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32251601
81* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31824405
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31694202
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31686345
84EWS_26573619_Chip-Seq_HEK293_Human1.31367176
85GATA4_25053715_ChIP-Seq_YYC3_Human1.31070815
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.29148784
87TBX3_20139965_ChIP-Seq_ESCs_Mouse1.26906073
88* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.26352311
89TBX3_20139965_ChIP-Seq_MESCs_Mouse1.25861239
90TTF2_22483619_ChIP-Seq_HELA_Human1.25605466
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24182326
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23720509
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.23033698
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22829068
95* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21469322
96* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19042061
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18358195
98MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18332424
99PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16921659
100* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16002584
101NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15838851
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15685956
103KDM2B_26808549_Chip-Seq_K562_Human1.15499462
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15351342
105MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14807923
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14661694
107* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14477485
108P300_19829295_ChIP-Seq_ESCs_Human1.13097039
109MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12258819
110* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.11987068
111MYC_22102868_ChIP-Seq_BL_Human1.11061394
112OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10261043
113TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08549952
114FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07855698
115GATA6_25053715_ChIP-Seq_YYC3_Human1.07752741
116* SOX9_26525672_Chip-Seq_HEART_Mouse1.06604247
117* ISL1_27105846_Chip-Seq_CPCs_Mouse1.06279779
118* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05832294
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05381674
120CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03495880
121* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01576641
122TP53_22127205_ChIP-Seq_IMR90_Human1.01284852
123KDM2B_26808549_Chip-Seq_DND41_Human1.00696654
124MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00337194
125* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00310108
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00119354
127PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99988077
128ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99668636
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99608045
130KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99397934
131BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98324993
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97761432
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97495052
134CHD1_26751641_Chip-Seq_LNCaP_Human0.97292744
135POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97181427
136* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96781579
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.96719757
138NANOG_21062744_ChIP-ChIP_HESCs_Human0.95964097
139NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.95506433
140MYC_18940864_ChIP-ChIP_HL60_Human0.95317142
141SMAD3_21741376_ChIP-Seq_HESCs_Human0.95044254
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94636280
143POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94277580
144KDM2B_26808549_Chip-Seq_JURKAT_Human0.93644520
145TCF4_18268006_ChIP-ChIP_LS174T_Human0.91694057
146* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91187611
147TAF15_26573619_Chip-Seq_HEK293_Human0.90973687
148XRN2_22483619_ChIP-Seq_HELA_Human0.90483691
149DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89932001
150* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89377516
151* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.89231129
152DCP1A_22483619_ChIP-Seq_HELA_Human0.88973890
153SMAD3_21741376_ChIP-Seq_EPCs_Human0.87624473
154* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87559663
155ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86301707
156PIAS1_25552417_ChIP-Seq_VCAP_Human0.86190199
157EOMES_21245162_ChIP-Seq_HESCs_Human0.86013798
158ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84907601
159CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84010557
160HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83878861

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane9.20386641
2MP0005623_abnormal_meninges_morphology7.39855509
3MP0009384_cardiac_valve_regurgitation6.16231014
4MP0004858_abnormal_nervous_system5.86520444
5MP0003941_abnormal_skin_development3.67126158
6MP0003119_abnormal_digestive_system3.09518566
7MP0003828_pulmonary_edema3.05594482
8MP0003136_yellow_coat_color3.04662402
9MP0003567_abnormal_fetal_cardiomyocyte2.98023032
10MP0001915_intracranial_hemorrhage2.58854201
11* MP0004957_abnormal_blastocyst_morpholog2.38028862
12MP0008057_abnormal_DNA_replication2.28922751
13MP0003705_abnormal_hypodermis_morpholog2.26484962
14MP0002938_white_spotting2.24253859
15MP0006292_abnormal_olfactory_placode2.22340952
16MP0003221_abnormal_cardiomyocyte_apopto2.12171149
17MP0000534_abnormal_ureter_morphology2.04272129
18MP0002233_abnormal_nose_morphology2.03314749
19MP0010094_abnormal_chromosome_stability1.99731544
20MP0003942_abnormal_urinary_system1.96923926
21MP0003115_abnormal_respiratory_system1.90919215
22MP0005084_abnormal_gallbladder_morpholo1.87889696
23MP0000566_synostosis1.87484706
24MP0002102_abnormal_ear_morphology1.85158666
25* MP0002084_abnormal_developmental_patter1.83225666
26MP0008438_abnormal_cutaneous_collagen1.80172381
27MP0006138_congestive_heart_failure1.75915969
28MP0002160_abnormal_reproductive_system1.75291455
29MP0004197_abnormal_fetal_growth/weight/1.71251283
30MP0004133_heterotaxia1.66740380
31MP0002127_abnormal_cardiovascular_syste1.63114116
32* MP0002086_abnormal_extraembryonic_tissu1.57379228
33MP0000579_abnormal_nail_morphology1.53834362
34MP0002139_abnormal_hepatobiliary_system1.49063905
35MP0002254_reproductive_system_inflammat1.49022318
36MP0001299_abnormal_eye_distance/1.48245185
37MP0008058_abnormal_DNA_repair1.47620987
38MP0009250_abnormal_appendicular_skeleto1.44683405
39MP0005171_absent_coat_pigmentation1.44623191
40* MP0001286_abnormal_eye_development1.40280175
41MP0001730_embryonic_growth_arrest1.40087813
42MP0003755_abnormal_palate_morphology1.37875420
43MP0005083_abnormal_biliary_tract1.37784551
44MP0005076_abnormal_cell_differentiation1.36678880
45* MP0001672_abnormal_embryogenesis/_devel1.30647614
46* MP0005380_embryogenesis_phenotype1.30647614
47MP0005248_abnormal_Harderian_gland1.28936007
48* MP0001697_abnormal_embryo_size1.26387507
49* MP0003984_embryonic_growth_retardation1.26337637
50MP0000383_abnormal_hair_follicle1.26153931
51MP0005164_abnormal_response_to1.26125002
52* MP0002088_abnormal_embryonic_growth/wei1.23902011
53MP0000767_abnormal_smooth_muscle1.20497771
54MP0003283_abnormal_digestive_organ1.18679114
55MP0002085_abnormal_embryonic_tissue1.18199092
56MP0004264_abnormal_extraembryonic_tissu1.18026359
57MP0000647_abnormal_sebaceous_gland1.15140487
58MP0003890_abnormal_embryonic-extraembry1.14881132
59MP0003315_abnormal_perineum_morphology1.12173331
60MP0003566_abnormal_cell_adhesion1.11512717
61MP0000537_abnormal_urethra_morphology1.08483972
62MP0000462_abnormal_digestive_system1.07463982
63MP0010678_abnormal_skin_adnexa1.07367617
64MP0002269_muscular_atrophy1.07275371
65MP0001346_abnormal_lacrimal_gland1.04533849
66MP0003091_abnormal_cell_migration1.04087892
67* MP0002697_abnormal_eye_size1.03655819
68MP0003123_paternal_imprinting1.02380685
69MP0010234_abnormal_vibrissa_follicle1.01894095
70MP0001661_extended_life_span1.01016908
71MP0002009_preneoplasia1.00873361
72MP0005391_vision/eye_phenotype1.00463336
73MP0000778_abnormal_nervous_system0.99152757
74MP0003279_aneurysm0.98817102
75MP0009697_abnormal_copulation0.97044380
76MP0005197_abnormal_uvea_morphology0.96299586
77MP0003718_maternal_effect0.96197482
78* MP0002080_prenatal_lethality0.94376221
79MP0003938_abnormal_ear_development0.94123286
80MP0005257_abnormal_intraocular_pressure0.93615218
81MP0005377_hearing/vestibular/ear_phenot0.93222978
82MP0003878_abnormal_ear_physiology0.93222978
83MP0006054_spinal_hemorrhage0.89388540
84MP0002116_abnormal_craniofacial_bone0.87625715
85MP0010307_abnormal_tumor_latency0.86135608
86MP0001958_emphysema0.85300439
87MP0003943_abnormal_hepatobiliary_system0.83736882
88MP0004233_abnormal_muscle_weight0.79350026
89MP0002109_abnormal_limb_morphology0.79333448
90MP0010352_gastrointestinal_tract_polyps0.79170778
91MP0002111_abnormal_tail_morphology0.78211151
92MP0009053_abnormal_anal_canal0.77688347
93MP0002896_abnormal_bone_mineralization0.77463145
94MP0003861_abnormal_nervous_system0.74860073
95MP0000516_abnormal_urinary_system0.74438598
96MP0005367_renal/urinary_system_phenotyp0.74438598
97MP0002925_abnormal_cardiovascular_devel0.73064793
98MP0003122_maternal_imprinting0.72933215
99MP0001177_atelectasis0.72828036
100MP0000631_abnormal_neuroendocrine_gland0.71499070
101MP0000733_abnormal_muscle_development0.70852824
102MP0005058_abnormal_lysosome_morphology0.70464895
103MP0002089_abnormal_postnatal_growth/wei0.69934604
104MP0001175_abnormal_lung_morphology0.69383047
105MP0003693_abnormal_embryo_hatching0.68730568
106MP0001293_anophthalmia0.67079707
107MP0005389_reproductive_system_phenotype0.65733386
108MP0003077_abnormal_cell_cycle0.65644130
109MP0000428_abnormal_craniofacial_morphol0.63660209
110MP0010630_abnormal_cardiac_muscle0.59580552
111MP0005193_abnormal_anterior_eye0.59464233
112MP0000432_abnormal_head_morphology0.57914268
113MP0003385_abnormal_body_wall0.57708970
114* MP0001614_abnormal_blood_vessel0.57073614
115* MP0009672_abnormal_birth_weight0.56213365
116MP0000350_abnormal_cell_proliferation0.56103842
117MP0002928_abnormal_bile_duct0.56005837
118MP0002128_abnormal_blood_circulation0.55655878
119MP0001849_ear_inflammation0.55603975
120MP0005376_homeostasis/metabolism_phenot0.55126665
121MP0010030_abnormal_orbit_morphology0.54816116
122MP0002081_perinatal_lethality0.52575926
123MP0003935_abnormal_craniofacial_develop0.51939327
124MP0008932_abnormal_embryonic_tissue0.50761937
125MP0003936_abnormal_reproductive_system0.50566675
126* MP0009703_decreased_birth_body0.50224644
127MP0000920_abnormal_myelination0.50081700
128MP0003111_abnormal_nucleus_morphology0.49688497
129MP0000049_abnormal_middle_ear0.48550849
130MP0004145_abnormal_muscle_electrophysio0.47700259
131MP0004087_abnormal_muscle_fiber0.47461630
132MP0002092_abnormal_eye_morphology0.46593508
133MP0003121_genomic_imprinting0.46351837
134MP0001784_abnormal_fluid_regulation0.46135268
135MP0000762_abnormal_tongue_morphology0.45816071
136MP0004085_abnormal_heartbeat0.45517800
137MP0003937_abnormal_limbs/digits/tail_de0.44577801
138MP0004883_abnormal_blood_vessel0.44285282
139MP0005621_abnormal_cell_physiology0.43423931
140MP0002653_abnormal_ependyma_morphology0.42850221
141MP0002133_abnormal_respiratory_system0.42077649
142MP0005388_respiratory_system_phenotype0.42077649
143MP0000266_abnormal_heart_morphology0.42063013
144MP0002106_abnormal_muscle_physiology0.41022559
145MP0000467_abnormal_esophagus_morphology0.40742850
146MP0002282_abnormal_trachea_morphology0.40602442
147MP0000639_abnormal_adrenal_gland0.40577129

Predicted human phenotypes

RankGene SetZ-score
1Occipital encephalocele (HP:0002085)6.85033374
2Abnormality of proline metabolism (HP:0010907)5.75008999
3Hydroxyprolinuria (HP:0003080)5.75008999
4Transposition of the great arteries (HP:0001669)5.19021845
5Abnormal connection of the cardiac segments (HP:0011545)5.19021845
6Abnormal ventriculo-arterial connection (HP:0011563)5.19021845
7Hypoplastic left heart (HP:0004383)5.04578490
8Cerebral aneurysm (HP:0004944)5.01012777
9Testicular neoplasm (HP:0010788)4.94232624
10Preauricular pit (HP:0004467)4.76640240
11Periauricular skin pits (HP:0100277)4.76640240
12Shallow orbits (HP:0000586)4.75864112
13Gonadal dysgenesis (HP:0000133)4.73373437
14Deviation of the thumb (HP:0009603)4.64761855
15Proximal placement of thumb (HP:0009623)4.36180189
16Preaxial foot polydactyly (HP:0001841)4.09355523
17Abnormal pancreas size (HP:0012094)4.01143735
18Premature rupture of membranes (HP:0001788)3.96613697
19Hypoplastic heart (HP:0001961)3.70177007
20Aplasia/Hypoplasia of the brainstem (HP:0007362)3.59171287
21Hypoplasia of the brainstem (HP:0002365)3.59171287
22Complete atrioventricular canal defect (HP:0001674)3.50678628
23Missing ribs (HP:0000921)3.44312198
24Knee flexion contracture (HP:0006380)3.36987924
25Metaphyseal cupping (HP:0003021)3.33880354
26Skin pits (HP:0100276)3.33215811
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.26775401
28Abnormality of the ischium (HP:0003174)3.21241018
29Abnormality of the fetal cardiovascular system (HP:0010948)3.20298019
30Abnormal umbilical cord blood vessels (HP:0011403)3.20298019
31Single umbilical artery (HP:0001195)3.20298019
32Patent foramen ovale (HP:0001655)3.17540163
33Hemiplegia (HP:0002301)3.14947642
34Bifid tongue (HP:0010297)3.13661793
35Pterygium (HP:0001059)2.97386915
36Abnormality of the aortic arch (HP:0012303)2.95132427
37Abnormal vertebral ossification (HP:0100569)2.92213365
38Abnormality of the 1st metacarpal (HP:0010009)2.92087751
39Metaphyseal dysplasia (HP:0100255)2.92012715
40Abnormality of the phalanges of the 2nd finger (HP:0009541)2.90121811
41Relative macrocephaly (HP:0004482)2.83294789
42High pitched voice (HP:0001620)2.79530970
43Underdeveloped supraorbital ridges (HP:0009891)2.78492062
44Atrioventricular canal defect (HP:0006695)2.78125295
45Anophthalmia (HP:0000528)2.73893582
46Protrusio acetabuli (HP:0003179)2.73122563
47Wormian bones (HP:0002645)2.73038142
48Lymphangioma (HP:0100764)2.68061772
49Short 1st metacarpal (HP:0010034)2.64142717
50Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.64142717
51Delayed epiphyseal ossification (HP:0002663)2.62137230
52Vitreoretinal degeneration (HP:0000655)2.57850586
53Bilateral microphthalmos (HP:0007633)2.53400403
54Abnormal tarsal ossification (HP:0008369)2.52430105
55Fused cervical vertebrae (HP:0002949)2.51582726
56Short tibia (HP:0005736)2.51081804
57Short humerus (HP:0005792)2.50097682
58Partial agenesis of the corpus callosum (HP:0001338)2.49089368
59Pulmonic stenosis (HP:0001642)2.47246523
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.47140498
61Abnormality of the proximal phalanges of the hand (HP:0009834)2.46813263
62Congenital malformation of the right heart (HP:0011723)2.43398753
63Double outlet right ventricle (HP:0001719)2.43398753
64Cutaneous finger syndactyly (HP:0010554)2.43078251
65Persistence of primary teeth (HP:0006335)2.42715248
66Abnormality of carpal bone ossification (HP:0006257)2.40302701
67Aplasia/hypoplasia of the humerus (HP:0006507)2.36197205
68Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.35868684
69High anterior hairline (HP:0009890)2.35506333
70Short phalanx of the thumb (HP:0009660)2.34928371
71Ovarian neoplasm (HP:0100615)2.34349747
72Abnormality of the middle phalanges of the toes (HP:0010183)2.34222830
73Hydroureter (HP:0000072)2.31781034
74Vertebral clefting (HP:0008428)2.30306954
75Polygenic inheritance (HP:0010982)2.28788445
76Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27627483
77Hip contracture (HP:0003273)2.26741041
78Abnormality of the nasal septum (HP:0000419)2.26448552
79Cutaneous syndactyly (HP:0012725)2.26064736
80Abnormality of the 2nd finger (HP:0004100)2.25523220
81Absent eyebrow (HP:0002223)2.22887304
82Hand muscle atrophy (HP:0009130)2.21426316
8311 pairs of ribs (HP:0000878)2.20800604
84Short hallux (HP:0010109)2.18915455
85Intestinal atresia (HP:0011100)2.18724354
86Chromsome breakage (HP:0040012)2.17933717
87Femoral bowing (HP:0002980)2.15433248
88Hypoplasia of the iris (HP:0007676)2.14318528
89Myelomeningocele (HP:0002475)2.13934528
90Abnormal ossification of hand bones (HP:0005921)2.11639996
91Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.11063819
92Exercise-induced muscle cramps (HP:0003710)2.10650166
93Aqueductal stenosis (HP:0002410)2.10239595
94Hypopigmentation of the fundus (HP:0007894)2.07118557
95Oligodactyly (hands) (HP:0001180)2.06123020
96Anal stenosis (HP:0002025)2.05339219
97Ulnar bowing (HP:0003031)2.05027365
98Colon cancer (HP:0003003)2.04942227
99Abnormality of the calcaneus (HP:0008364)2.04226818
100Back pain (HP:0003418)2.03814126
101Abnormal lung lobation (HP:0002101)2.03006053
102Truncus arteriosus (HP:0001660)2.02259230
103Hepatoblastoma (HP:0002884)2.02187595
104Absent radius (HP:0003974)2.01135246
105Abnormality of dentin (HP:0010299)1.99410092
106Hypoplastic pelvis (HP:0008839)1.99119278
107Vertebral hypoplasia (HP:0008417)1.99001125
108Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.99001125
109Abnormality of the lacrimal duct (HP:0011481)1.97580557
110Partial duplication of thumb phalanx (HP:0009944)1.97511775
111Aplasia/Hypoplasia of the hallux (HP:0008362)1.97229496
112Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.96145504
113Elbow flexion contracture (HP:0002987)1.93660248
114Abnormal hand bone ossification (HP:0010660)1.93435519
115Calcaneovalgus deformity (HP:0001848)1.93000730
116Ectopic anus (HP:0004397)1.92906032
117Broad thumb (HP:0011304)1.92814334
118Coronal craniosynostosis (HP:0004440)1.91090094
119Abnormal foot bone ossification (HP:0010675)1.90656754
120Facial cleft (HP:0002006)1.89339173
121Septo-optic dysplasia (HP:0100842)1.89163774
122Cervical subluxation (HP:0003308)1.88690253
123Abnormality of the phalanges of the 5th finger (HP:0004213)1.88401669
124Hypoplasia of the ulna (HP:0003022)1.87989487
125Cupped ear (HP:0000378)1.87311162
126Abnormality of the umbilical cord (HP:0010881)1.87161047
127Abnormality of the nasolacrimal system (HP:0000614)1.86933631
128Distal upper limb amyotrophy (HP:0007149)1.86443811
129Upper limb amyotrophy (HP:0009129)1.86443811
130Duplication of thumb phalanx (HP:0009942)1.86419538
131Aplasia involving forearm bones (HP:0009822)1.86364173
132Absent forearm bone (HP:0003953)1.86364173
133Inguinal hernia (HP:0000023)1.84198406
134Morphological abnormality of the middle ear (HP:0008609)1.84144556
135Synostosis of carpal bones (HP:0005048)1.84035697
136Radial bowing (HP:0002986)1.82970598
137Increased nuchal translucency (HP:0010880)1.80920078
138Turricephaly (HP:0000262)1.80300450
139Choanal stenosis (HP:0000452)1.79946726
140Oligodactyly (HP:0012165)1.79890297
141Platyspondyly (HP:0000926)1.79471254
142Neonatal death (HP:0003811)1.79416818
143Stenosis of the external auditory canal (HP:0000402)1.79348420
144Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.79152245
145Ectopic kidney (HP:0000086)1.79004334
146Congenital diaphragmatic hernia (HP:0000776)1.78698505
147Renal hypoplasia (HP:0000089)1.78625603
148Fibular hypoplasia (HP:0003038)1.77553920
149Severe short stature (HP:0003510)1.77467280
150Visceral angiomatosis (HP:0100761)1.75958203
151Partial duplication of the phalanx of hand (HP:0009999)1.75380530
152Right ventricular cardiomyopathy (HP:0011663)1.73560235
153Osteopenia (HP:0000938)1.73041901
154Tetraparesis (HP:0002273)1.72951890
155Flat acetabular roof (HP:0003180)1.71973076
156Aneurysm (HP:0002617)1.71931050
157Broad ribs (HP:0000885)1.70605436
158Bell-shaped thorax (HP:0001591)1.69692919
159Midline defect of the nose (HP:0004122)1.69688081
160Volvulus (HP:0002580)1.69311318
161Bicornuate uterus (HP:0000813)1.68126419
162Thin ribs (HP:0000883)1.67213776
163Hypoplastic labia majora (HP:0000059)1.67097354
164Deformed tarsal bones (HP:0008119)1.67019946
165Renal duplication (HP:0000075)1.66045696
166Hemangiomatosis (HP:0007461)1.65632053
167Absent eyelashes (HP:0000561)1.65466974
168Absent epiphyses (HP:0010577)1.64376902
169Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64376902
170Female pseudohermaphroditism (HP:0010458)1.63734520
171Aplasia/Hypoplasia of the uvula (HP:0010293)1.63692204
172Midface retrusion (HP:0011800)1.63050468
173Aplasia/Hypoplasia of the sternum (HP:0006714)1.62273311
174Broad toe (HP:0001837)1.61561177
175Aplasia/Hypoplasia of the ulna (HP:0006495)1.60338745
176Abnormal number of incisors (HP:0011064)1.60333872
177Aplasia involving bones of the extremities (HP:0009825)1.59635675
178Aplasia involving bones of the upper limbs (HP:0009823)1.59635675
179Aplasia of the phalanges of the hand (HP:0009802)1.59635675
180Broad finger (HP:0001500)1.59026164
181Gastrointestinal atresia (HP:0002589)1.58780489
182Labial hypoplasia (HP:0000066)1.57257396
183Absent septum pellucidum (HP:0001331)1.57159024
184Embryonal renal neoplasm (HP:0011794)1.56918318
185Meckel diverticulum (HP:0002245)1.56712354
186Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.56372409
187Abnormality of alanine metabolism (HP:0010916)1.56372409
188Hyperalaninemia (HP:0003348)1.56372409
189Abnormality of the antihelix (HP:0009738)1.56093403
190Coarctation of aorta (HP:0001680)1.54739722
191Hypospadias (HP:0000047)1.54565970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK26.70019805
2TYRO34.88000244
3CDK44.16616279
4PBK3.63485035
5SCYL23.62754219
6LATS23.58167568
7FGFR43.48358333
8PDGFRA2.90021787
9DDR22.76394324
10PKN22.48901427
11CDK122.48631508
12WNK42.33715832
13EEF2K2.20252492
14MATK2.18492220
15EPHA22.15988810
16TRIB32.15089204
17MST1R2.03358851
18STK392.02513532
19FGFR21.99041765
20MKNK21.88801760
21DMPK1.83732784
22PTK61.76997043
23NEK11.76808766
24OBSCN1.73240079
25ZAK1.71426685
26LATS11.71088831
27STK38L1.68010767
28OXSR11.67726089
29SRPK11.60108613
30NEK21.59934128
31WEE11.58123507
32BRSK21.52236771
33FLT31.49001825
34PLK41.46698613
35MAP3K101.44723995
36CDC71.44409605
37BMPR1B1.42421015
38MAP3K91.35453525
39ALK1.32703708
40BCR1.31968221
41STK161.27259452
42CHEK11.27049471
43RPS6KB21.27032615
44NEK61.24231316
45CASK1.20150699
46ICK1.19796014
47PNCK1.15934977
48MTOR1.15330659
49WNK31.09663643
50FGR1.09466365
51FER1.07903684
52TGFBR11.06224571
53CAMK1G1.05672160
54MAP3K81.01503259
55BUB11.00249883
56ACVR1B1.00081861
57PTK20.99713948
58FGFR10.98776003
59ATR0.97893880
60PAK40.97876214
61CAMK1D0.97730931
62EPHA40.95716434
63STK30.94975170
64RIPK10.94179741
65EPHB20.92291833
66TIE10.87313099
67AKT30.86885828
68RPS6KA40.86379349
69PASK0.86023820
70PDGFRB0.85129737
71PLK10.81483151
72DAPK20.79534577
73PLK30.76652015
74LRRK20.74839928
75KSR20.74817076
76KSR10.74795044
77DAPK30.73059305
78TTK0.72332625
79CDK190.72288861
80ERBB40.71735123
81CDC42BPA0.71681950
82ATM0.70588172
83CDK60.68191218
84CSNK1G10.67825262
85PRKD30.66647182
86RPS6KA20.65723011
87LIMK10.65361327
88MAPK10.64958411
89MELK0.64802651
90TNIK0.62917353
91TTN0.60688827
92FRK0.60573362
93AURKA0.60328500
94NUAK10.60054488
95CDK70.59846957
96PAK30.59171039
97STK100.58459359
98CHUK0.57223951
99CDK20.57147440
100UHMK10.54356058
101CSNK1E0.54245189
102BRD40.52585807
103STK110.51591519
104BRSK10.50056717
105MAP2K10.49634677
106RPS6KA10.48948359
107RPS6KC10.48308535
108RPS6KL10.48308535
109SIK10.46414171
110TSSK60.45804591
111MKNK10.44032038
112PRKCI0.43476606
113CSNK1D0.43098234
114PAK10.41986194
115PRKDC0.41912689
116AKT20.41165186
117TRIM280.40389116
118CSNK1A1L0.40314558
119PRKD10.40153906
120PLK20.39938474
121PAK20.39933366
122NLK0.39594377
123MET0.39149917
124TAF10.38871151
125RPS6KA60.38468726
126AURKB0.37397134
127MAP2K20.36816547
128NTRK20.36229598
129CDK30.35713319
130GSK3B0.35562838
131CDK140.34308719
132EIF2AK30.34237396
133BMX0.33332397
134ERN10.33018053
135STK240.32821687
136MAP3K40.32293273
137MAPKAPK50.32025624
138GRK60.31971433
139INSR0.31887825
140CDK10.31844875
141CDK150.30604764
142MAP3K30.29842400
143CHEK20.29403309
144MAPK140.28822268
145DYRK30.28780140
146MAPK100.28772923
147NTRK10.26788242
148CSNK1G30.25338196
149RPS6KB10.24933124
150PRKACB0.24103805
151AKT10.23701186

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005248.39054286
2* Small cell lung cancer_Homo sapiens_hsa052223.94557394
3* ECM-receptor interaction_Homo sapiens_hsa045123.76966901
4Prion diseases_Homo sapiens_hsa050203.18647288
5* Amoebiasis_Homo sapiens_hsa051463.14887429
6Nitrogen metabolism_Homo sapiens_hsa009102.87891459
7Non-homologous end-joining_Homo sapiens_hsa034502.81840484
8Lysine degradation_Homo sapiens_hsa003102.44230063
9Galactose metabolism_Homo sapiens_hsa000522.34575652
10* Toxoplasmosis_Homo sapiens_hsa051451.95878588
11Fanconi anemia pathway_Homo sapiens_hsa034601.91691859
12* Focal adhesion_Homo sapiens_hsa045101.88194790
13Cysteine and methionine metabolism_Homo sapiens_hsa002701.82209102
14Homologous recombination_Homo sapiens_hsa034401.71707091
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68646878
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66516123
17Hippo signaling pathway_Homo sapiens_hsa043901.59564121
18Nucleotide excision repair_Homo sapiens_hsa034201.58077715
19Hedgehog signaling pathway_Homo sapiens_hsa043401.53555136
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.51959759
21Basal cell carcinoma_Homo sapiens_hsa052171.51691575
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50416738
23Fructose and mannose metabolism_Homo sapiens_hsa000511.44890304
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.44645894
25Arginine and proline metabolism_Homo sapiens_hsa003301.40462823
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.39791422
27Steroid biosynthesis_Homo sapiens_hsa001001.39746948
28One carbon pool by folate_Homo sapiens_hsa006701.36474789
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33898349
30Propanoate metabolism_Homo sapiens_hsa006401.31521702
31Pyruvate metabolism_Homo sapiens_hsa006201.30447346
32Vitamin digestion and absorption_Homo sapiens_hsa049771.28909328
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28330846
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.25491037
35Basal transcription factors_Homo sapiens_hsa030221.21307305
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19032352
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18737867
38Base excision repair_Homo sapiens_hsa034101.17909319
39* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.17531236
40* Pathways in cancer_Homo sapiens_hsa052001.16493672
41Vibrio cholerae infection_Homo sapiens_hsa051101.15810198
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11375682
43Carbon metabolism_Homo sapiens_hsa012001.08513948
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08484829
45Biosynthesis of amino acids_Homo sapiens_hsa012301.01197366
46RNA transport_Homo sapiens_hsa030131.00165176
47Tight junction_Homo sapiens_hsa045300.99587866
48Proteoglycans in cancer_Homo sapiens_hsa052050.99331517
49Melanogenesis_Homo sapiens_hsa049160.97997547
50Type II diabetes mellitus_Homo sapiens_hsa049300.96584715
51Purine metabolism_Homo sapiens_hsa002300.95109573
52Adherens junction_Homo sapiens_hsa045200.94938220
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93228665
54Arginine biosynthesis_Homo sapiens_hsa002200.91170898
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90353420
56RNA polymerase_Homo sapiens_hsa030200.88533652
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87445486
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84577080
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84495040
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82769032
61DNA replication_Homo sapiens_hsa030300.79955024
62Pyrimidine metabolism_Homo sapiens_hsa002400.77388362
63Wnt signaling pathway_Homo sapiens_hsa043100.76737427
64Starch and sucrose metabolism_Homo sapiens_hsa005000.76727714
65Bladder cancer_Homo sapiens_hsa052190.75112382
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69154428
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68171750
68TGF-beta signaling pathway_Homo sapiens_hsa043500.67605284
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67406073
70HIF-1 signaling pathway_Homo sapiens_hsa040660.64819179
71Thyroid hormone synthesis_Homo sapiens_hsa049180.64104234
72Cell cycle_Homo sapiens_hsa041100.62616918
73Complement and coagulation cascades_Homo sapiens_hsa046100.62238648
74Fat digestion and absorption_Homo sapiens_hsa049750.59147898
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58927017
76Insulin resistance_Homo sapiens_hsa049310.58087984
77Estrogen signaling pathway_Homo sapiens_hsa049150.57377116
78N-Glycan biosynthesis_Homo sapiens_hsa005100.56495125
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54655238
80Bile secretion_Homo sapiens_hsa049760.54651407
81Oocyte meiosis_Homo sapiens_hsa041140.54631704
82Fatty acid metabolism_Homo sapiens_hsa012120.54561260
83Sulfur relay system_Homo sapiens_hsa041220.54415955
84Melanoma_Homo sapiens_hsa052180.53583889
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53092977
86MicroRNAs in cancer_Homo sapiens_hsa052060.53004835
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52912777
88Rap1 signaling pathway_Homo sapiens_hsa040150.52819213
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.52775914
90Glucagon signaling pathway_Homo sapiens_hsa049220.52389517
91mRNA surveillance pathway_Homo sapiens_hsa030150.51468928
92Glutathione metabolism_Homo sapiens_hsa004800.51411338
93Folate biosynthesis_Homo sapiens_hsa007900.51232104
94Axon guidance_Homo sapiens_hsa043600.50804039
95mTOR signaling pathway_Homo sapiens_hsa041500.48637656
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47707644
97Viral carcinogenesis_Homo sapiens_hsa052030.47380925
98Sphingolipid metabolism_Homo sapiens_hsa006000.46124042
99Cocaine addiction_Homo sapiens_hsa050300.46091565
100Renal cell carcinoma_Homo sapiens_hsa052110.45783252
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45673315
102AMPK signaling pathway_Homo sapiens_hsa041520.45503923
103Prostate cancer_Homo sapiens_hsa052150.45097323
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44589545
105Selenocompound metabolism_Homo sapiens_hsa004500.44307061
106Mismatch repair_Homo sapiens_hsa034300.43923254
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42743284
108Butanoate metabolism_Homo sapiens_hsa006500.41462865
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41394591
110p53 signaling pathway_Homo sapiens_hsa041150.40348118
111ErbB signaling pathway_Homo sapiens_hsa040120.40205464
112Ribosome_Homo sapiens_hsa030100.40008916
113Ovarian steroidogenesis_Homo sapiens_hsa049130.39961995
114Metabolic pathways_Homo sapiens_hsa011000.39796665
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39324630
116Spliceosome_Homo sapiens_hsa030400.38489427
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38423672
118HTLV-I infection_Homo sapiens_hsa051660.37478591
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36929093
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36347826
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33818538
122Fatty acid elongation_Homo sapiens_hsa000620.33147367
123beta-Alanine metabolism_Homo sapiens_hsa004100.32906989
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32806466
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31960682
126Pentose phosphate pathway_Homo sapiens_hsa000300.31951900
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31357892
128Fatty acid biosynthesis_Homo sapiens_hsa000610.31066842
129Inositol phosphate metabolism_Homo sapiens_hsa005620.30682415
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30254380
131Insulin signaling pathway_Homo sapiens_hsa049100.29270922
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28659660
133Thyroid cancer_Homo sapiens_hsa052160.25405645
134Lysosome_Homo sapiens_hsa041420.24926669
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.24200481
136Protein digestion and absorption_Homo sapiens_hsa049740.24035946
137Endocytosis_Homo sapiens_hsa041440.23610838
138Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.23088872
139Hepatitis B_Homo sapiens_hsa051610.20111958
140RNA degradation_Homo sapiens_hsa030180.19013962
141Colorectal cancer_Homo sapiens_hsa052100.17690491

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