LAMA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.60762417
2basement membrane organization (GO:0071711)5.06453353
3collagen fibril organization (GO:0030199)5.00713430
4retina vasculature morphogenesis in camera-type eye (GO:0061299)4.74898926
5vascular endothelial growth factor signaling pathway (GO:0038084)4.60952163
6cardiac myofibril assembly (GO:0055003)4.47223200
7glomerular filtration (GO:0003094)4.34226434
8neuron projection extension involved in neuron projection guidance (GO:1902284)4.01693636
9axon extension involved in axon guidance (GO:0048846)4.01693636
10renal filtration (GO:0097205)3.97835210
11sequestering of extracellular ligand from receptor (GO:0035581)3.95828270
12bone trabecula formation (GO:0060346)3.94091399
13plasma membrane repair (GO:0001778)3.90923738
14collagen metabolic process (GO:0032963)3.87092927
15regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.82052615
16blood vessel maturation (GO:0001955)3.81437987
17wound healing, spreading of epidermal cells (GO:0035313)3.79113623
18insulin-like growth factor receptor signaling pathway (GO:0048009)3.78624883
19collagen catabolic process (GO:0030574)3.78163326
20multicellular organismal macromolecule metabolic process (GO:0044259)3.72022877
21chondrocyte proliferation (GO:0035988)3.69477225
22trabecula formation (GO:0060343)3.68427129
23heart trabecula formation (GO:0060347)3.66727429
24lymph vessel development (GO:0001945)3.65771188
25type B pancreatic cell proliferation (GO:0044342)3.63655255
26endodermal cell differentiation (GO:0035987)3.61564828
27cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.58222650
28multicellular organismal metabolic process (GO:0044236)3.56666400
29endothelial cell morphogenesis (GO:0001886)3.52201309
30multicellular organismal catabolic process (GO:0044243)3.50874562
31extracellular matrix disassembly (GO:0022617)3.47824980
32metanephric mesenchyme development (GO:0072075)3.47627316
33myofibril assembly (GO:0030239)3.46694797
34cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.41679522
35mesenchymal-epithelial cell signaling (GO:0060638)3.37882643
36kidney mesenchyme development (GO:0072074)3.37572191
37cell migration involved in sprouting angiogenesis (GO:0002042)3.36374859
38substrate-dependent cell migration (GO:0006929)3.32600809
39extracellular fibril organization (GO:0043206)3.31579664
40dermatan sulfate metabolic process (GO:0030205)3.28830709
41glomerular basement membrane development (GO:0032836)3.26090853
42hippo signaling (GO:0035329)3.22088473
43positive regulation of endothelial cell apoptotic process (GO:2000353)3.21064792
44hemidesmosome assembly (GO:0031581)3.20405661
45sprouting angiogenesis (GO:0002040)3.18963621
46negative regulation of focal adhesion assembly (GO:0051895)3.17173021
47negative regulation of cell junction assembly (GO:1901889)3.17173021
48negative regulation of adherens junction organization (GO:1903392)3.17173021
49low-density lipoprotein particle clearance (GO:0034383)3.13893355
50sarcomere organization (GO:0045214)3.12802714
51keratan sulfate catabolic process (GO:0042340)3.12375073
52cardiac muscle cell proliferation (GO:0060038)3.10067773
53positive regulation of glycogen biosynthetic process (GO:0045725)3.08029320
54heart morphogenesis (GO:0003007)3.07612206
55ovulation from ovarian follicle (GO:0001542)3.04777829
56cell adhesion mediated by integrin (GO:0033627)3.04056953
57skin morphogenesis (GO:0043589)3.01969792
58cell-substrate junction assembly (GO:0007044)3.00449568
59branching involved in salivary gland morphogenesis (GO:0060445)2.99349104
60positive regulation of fatty acid oxidation (GO:0046321)2.97506861
61lymphangiogenesis (GO:0001946)2.97417934
62substrate adhesion-dependent cell spreading (GO:0034446)2.97142586
63smooth muscle tissue development (GO:0048745)2.96303245
64peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.96165269
65negative regulation of chondrocyte differentiation (GO:0032331)2.95773594
66negative regulation of catenin import into nucleus (GO:0035414)2.95517027
67patterning of blood vessels (GO:0001569)2.95321921
68positive regulation of fatty acid beta-oxidation (GO:0032000)2.93126100
69regulation of axon extension involved in axon guidance (GO:0048841)2.91466117
70negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.88497705
71fibril organization (GO:0097435)2.87648855
72positive regulation of fibroblast migration (GO:0010763)2.86809386
73regulation of integrin-mediated signaling pathway (GO:2001044)2.84228889
74peripheral nervous system axon ensheathment (GO:0032292)2.83905150
75myelination in peripheral nervous system (GO:0022011)2.83905150
76artery development (GO:0060840)2.83611237
77fatty acid transmembrane transport (GO:1902001)2.81382594
78epithelial cell-cell adhesion (GO:0090136)2.81101429
79regulation of cardioblast differentiation (GO:0051890)2.77534212
80cell migration involved in heart development (GO:0060973)2.76708919
81carnitine shuttle (GO:0006853)2.76238477
82negative regulation of blood vessel endothelial cell migration (GO:0043537)2.74108357
83cellular response to vitamin (GO:0071295)2.73387851
84dermatan sulfate biosynthetic process (GO:0030208)2.72012255
85barbed-end actin filament capping (GO:0051016)2.71970475
86negative regulation of endothelial cell proliferation (GO:0001937)2.71878842
87endothelial cell proliferation (GO:0001935)2.70904667
88adherens junction assembly (GO:0034333)2.70572221
89wound healing, spreading of cells (GO:0044319)2.70482269
90positive regulation of blood vessel endothelial cell migration (GO:0043536)2.70420657
91negative regulation of axon extension involved in axon guidance (GO:0048843)2.69952900
92negative regulation of cartilage development (GO:0061037)2.69880885
93regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.69578830
94regulation of sequestering of triglyceride (GO:0010889)2.68835123
95apoptotic cell clearance (GO:0043277)2.68568086
96negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.68113232
97vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.66729517
98actomyosin structure organization (GO:0031032)2.66722210
99extracellular matrix assembly (GO:0085029)2.66615882
100virion attachment to host cell (GO:0019062)2.66548097
101adhesion of symbiont to host cell (GO:0044650)2.66548097
102actin-myosin filament sliding (GO:0033275)2.66326499
103muscle filament sliding (GO:0030049)2.66326499
104endothelium development (GO:0003158)2.65999067
105regulation of tight junction assembly (GO:2000810)2.65613517
106blood vessel endothelial cell migration (GO:0043534)2.65531634
107cell proliferation involved in metanephros development (GO:0072203)2.65374499
108regulation of plasminogen activation (GO:0010755)2.65188656
109positive regulation of osteoblast proliferation (GO:0033690)2.64819325
110white fat cell differentiation (GO:0050872)2.62983474
111* extracellular matrix organization (GO:0030198)2.62342071
112regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.62178807
113protein localization to cell surface (GO:0034394)2.62007733
114endocardial cushion development (GO:0003197)2.61763599
115* extracellular structure organization (GO:0043062)2.61114755
116regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.60341839
117growth hormone receptor signaling pathway (GO:0060396)2.59244022
118positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.59106206
119positive regulation of cartilage development (GO:0061036)2.58879863
120positive regulation of epithelial to mesenchymal transition (GO:0010718)2.58350581
121dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.58313010
122fibroblast migration (GO:0010761)2.58164388
123striated muscle cell proliferation (GO:0014855)2.57991004
124positive regulation of endothelial cell migration (GO:0010595)2.57653110
125regulation of chondrocyte differentiation (GO:0032330)2.57444290
126positive regulation of receptor recycling (GO:0001921)2.57095381
127regulation of cartilage development (GO:0061035)2.57093307
128regulation of axon guidance (GO:1902667)2.57066712
129negative regulation of fatty acid transport (GO:2000192)2.56692080
130positive regulation of glycogen metabolic process (GO:0070875)2.55912045
131negative regulation of smooth muscle cell migration (GO:0014912)2.55882501
132cardiac muscle cell development (GO:0055013)2.55707365
133negative regulation of cardiac muscle tissue growth (GO:0055022)2.54849155
134negative regulation of heart growth (GO:0061117)2.54849155
135regulation of endothelial cell differentiation (GO:0045601)2.54099675
136coronary vasculature morphogenesis (GO:0060977)2.53751454
137positive regulation of astrocyte differentiation (GO:0048711)2.53652694
138venous blood vessel morphogenesis (GO:0048845)2.53270238
139negative regulation of potassium ion transmembrane transport (GO:1901380)2.52877740
140extracellular regulation of signal transduction (GO:1900115)2.50607523
141extracellular negative regulation of signal transduction (GO:1900116)2.50607523
142chondrocyte development (GO:0002063)2.50410638
143regulation of smooth muscle cell migration (GO:0014910)2.49983182
144cell-substrate adhesion (GO:0031589)2.49828066
145regulation of chemokine-mediated signaling pathway (GO:0070099)2.48476363
146hyaluronan catabolic process (GO:0030214)2.47629272
147endocrine hormone secretion (GO:0060986)2.47008053
148negative chemotaxis (GO:0050919)2.45834161
149negative regulation of endothelial cell migration (GO:0010596)2.45788621

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.17270544
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.80150505
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.15136422
4CLOCK_20551151_ChIP-Seq_293T_Human3.34127149
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.27457673
6EP300_21415370_ChIP-Seq_HL-1_Mouse3.13848967
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.89316431
8* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.86690418
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.48716203
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.45660058
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.42996120
12* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.37209992
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32249858
14* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.32206567
15* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.21682429
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.14367073
17* CJUN_26792858_Chip-Seq_BT549_Human2.10896614
18TBX20_22080862_ChIP-Seq_HEART_Mouse1.98848734
19TBX20_22328084_ChIP-Seq_HEART_Mouse1.98848734
20CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.90958858
21RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.87843181
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.81338179
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.80960226
24* GATA2_21666600_ChIP-Seq_HMVEC_Human1.79947209
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79675798
26* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76070788
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74828464
28BRD4_25478319_ChIP-Seq_HGPS_Human1.74588306
29* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.71994263
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66872187
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64064292
32ZNF263_19887448_ChIP-Seq_K562_Human1.61701143
33ISL1_27105846_Chip-Seq_CPCs_Mouse1.57419175
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55023616
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.51331599
36* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.51182050
37* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.51182050
38* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.50581522
39MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.50125084
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48018011
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47902248
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47902248
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.47245722
44GBX2_23144817_ChIP-Seq_PC3_Human1.46156061
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.45085344
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44019812
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43891907
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39399395
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36605333
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35639163
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.35466860
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32873308
53TP53_16413492_ChIP-PET_HCT116_Human1.31337414
54* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30129922
55* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29484274
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29339583
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29130555
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.27975667
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.27773466
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27169707
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.26845244
62* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25027404
63SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23546835
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23546835
65* SMAD_19615063_ChIP-ChIP_OVARY_Human1.22932830
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22318886
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21346983
68AHR_22903824_ChIP-Seq_MCF-7_Human1.21124292
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20729441
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16456006
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15415662
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14976150
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14332875
74TP53_18474530_ChIP-ChIP_U2OS_Human1.14200201
75NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13231075
76SA1_22415368_ChIP-Seq_MEFs_Mouse1.13127278
77SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12563913
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11916056
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11664459
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11235340
81UBF1/2_26484160_Chip-Seq_HMECs_Human1.10836893
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10425935
83SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10042848
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.08759447
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08441580
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06201998
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05894195
88TP53_23651856_ChIP-Seq_MEFs_Mouse1.05718297
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.05247071
90* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.05040895
91SOX2_20726797_ChIP-Seq_SW620_Human1.03999564
92* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03510351
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02958181
94JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02410457
95EZH2_27294783_Chip-Seq_ESCs_Mouse1.01511274
96SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01429902
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.00894889
98SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00020736
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98886570
100TP53_20018659_ChIP-ChIP_R1E_Mouse0.98870734
101FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.97838473
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95427310
103KDM2B_26808549_Chip-Seq_K562_Human0.94437947
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92611745
105EZH2_27304074_Chip-Seq_ESCs_Mouse0.92585882
106TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92168055
107MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91305702
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91080064
109SMAD4_21799915_ChIP-Seq_A2780_Human0.90637234
110RING1B_27294783_Chip-Seq_ESCs_Mouse0.90613454
111BCAT_22108803_ChIP-Seq_LS180_Human0.90493131
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90287928
113LXR_22158963_ChIP-Seq_LIVER_Mouse0.89962907
114GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89357521
115SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89030628
116AR_21572438_ChIP-Seq_LNCaP_Human0.88552738
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88271180
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88067952
119* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87948258
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87793044
121YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87611934
122VDR_24787735_ChIP-Seq_THP-1_Human0.86355028
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86211481
124TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85856389
125TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85551568
126TP53_22127205_ChIP-Seq_IMR90_Human0.85269427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.90320190
2* MP0004272_abnormal_basement_membrane4.62338944
3MP0005275_abnormal_skin_tensile4.53119791
4MP0005503_abnormal_tendon_morphology3.95898805
5MP0003705_abnormal_hypodermis_morpholog3.55548775
6MP0003279_aneurysm3.24916380
7MP0010368_abnormal_lymphatic_system2.86282865
8MP0000751_myopathy2.71339440
9MP0004084_abnormal_cardiac_muscle2.63219220
10MP0002837_dystrophic_cardiac_calcinosis2.55520386
11MP0001958_emphysema2.37305580
12MP0005623_abnormal_meninges_morphology2.25156938
13MP0001879_abnormal_lymphatic_vessel2.21006779
14MP0006054_spinal_hemorrhage1.99849339
15MP0005670_abnormal_white_adipose1.93068087
16MP0003828_pulmonary_edema1.91083610
17MP0005171_absent_coat_pigmentation1.89432231
18MP0002108_abnormal_muscle_morphology1.88635558
19MP0000013_abnormal_adipose_tissue1.84837592
20MP0003566_abnormal_cell_adhesion1.73435038
21MP0006138_congestive_heart_failure1.71987737
22MP0004215_abnormal_myocardial_fiber1.68615953
23MP0004130_abnormal_muscle_cell1.67050306
24MP0009384_cardiac_valve_regurgitation1.65166723
25MP0001542_abnormal_bone_strength1.64971457
26MP0000750_abnormal_muscle_regeneration1.63405261
27MP0004036_abnormal_muscle_relaxation1.60282595
28MP0003045_fibrosis1.54751457
29MP0008775_abnormal_heart_ventricle1.54469147
30MP0005508_abnormal_skeleton_morphology1.52061869
31MP0004145_abnormal_muscle_electrophysio1.51057092
32MP0005666_abnormal_adipose_tissue1.49737545
33* MP0004087_abnormal_muscle_fiber1.46383187
34MP0004858_abnormal_nervous_system1.44641316
35MP0002060_abnormal_skin_morphology1.43254800
36MP0001544_abnormal_cardiovascular_syste1.41693175
37MP0005385_cardiovascular_system_phenoty1.41693175
38MP0003385_abnormal_body_wall1.41388050
39* MP0005330_cardiomyopathy1.39602127
40MP0000767_abnormal_smooth_muscle1.38110925
41MP0004185_abnormal_adipocyte_glucose1.38008785
42MP0000749_muscle_degeneration1.37021556
43* MP0010630_abnormal_cardiac_muscle1.35231394
44MP0000733_abnormal_muscle_development1.34902780
45MP0000003_abnormal_adipose_tissue1.34693504
46MP0002295_abnormal_pulmonary_circulatio1.34125390
47MP0005375_adipose_tissue_phenotype1.34008041
48MP0003950_abnormal_plasma_membrane1.32744762
49MP0009250_abnormal_appendicular_skeleto1.31239518
50* MP0002972_abnormal_cardiac_muscle1.24882019
51* MP0005620_abnormal_muscle_contractility1.17521564
52MP0002896_abnormal_bone_mineralization1.15548809
53MP0002933_joint_inflammation1.14123453
54MP0003122_maternal_imprinting1.11619544
55MP0002877_abnormal_melanocyte_morpholog1.11369225
56MP0000759_abnormal_skeletal_muscle1.09391491
57MP0003091_abnormal_cell_migration1.08065133
58MP0005369_muscle_phenotype1.07238582
59MP0004484_altered_response_of1.06543453
60* MP0002128_abnormal_blood_circulation1.04392312
61MP0003567_abnormal_fetal_cardiomyocyte1.02609349
62MP0002106_abnormal_muscle_physiology1.02403965
63MP0000534_abnormal_ureter_morphology1.01983103
64MP0002282_abnormal_trachea_morphology0.98251327
65MP0003115_abnormal_respiratory_system0.98181283
66MP0005257_abnormal_intraocular_pressure0.97650745
67MP0002925_abnormal_cardiovascular_devel0.97484203
68MP0003941_abnormal_skin_development0.97463108
69MP0003942_abnormal_urinary_system0.97415348
70MP0005023_abnormal_wound_healing0.96831753
71MP0004134_abnormal_chest_morphology0.96540660
72MP0002168_other_aberrant_phenotype0.96414278
73MP0000049_abnormal_middle_ear0.95314606
74* MP0001614_abnormal_blood_vessel0.94346891
75MP0010352_gastrointestinal_tract_polyps0.94089925
76MP0005164_abnormal_response_to0.94003451
77* MP0000266_abnormal_heart_morphology0.92146094
78MP0009780_abnormal_chondrocyte_physiolo0.92142493
79MP0001661_extended_life_span0.90267909
80MP0000428_abnormal_craniofacial_morphol0.89865194
81MP0005595_abnormal_vascular_smooth0.86909282
82MP0003935_abnormal_craniofacial_develop0.86390987
83MP0003283_abnormal_digestive_organ0.86053411
84MP0000537_abnormal_urethra_morphology0.83657616
85MP0000163_abnormal_cartilage_morphology0.81877850
86MP0001915_intracranial_hemorrhage0.81748542
87MP0005167_abnormal_blood-brain_barrier0.81237121
88MP0001299_abnormal_eye_distance/0.81034737
89MP0000249_abnormal_blood_vessel0.80623926
90MP0005409_darkened_coat_color0.79412506
91MP0002938_white_spotting0.79345333
92MP0010386_abnormal_urinary_bladder0.79255113
93MP0002115_abnormal_skeleton_extremities0.79109622
94MP0005165_increased_susceptibility_to0.78450173
95MP0000462_abnormal_digestive_system0.77157125
96MP0002133_abnormal_respiratory_system0.77015423
97MP0005388_respiratory_system_phenotype0.77015423
98MP0010030_abnormal_orbit_morphology0.76797796
99MP0000343_altered_response_to0.76700191
100MP0002932_abnormal_joint_morphology0.75656788
101MP0004233_abnormal_muscle_weight0.75036119
102MP0001243_abnormal_dermal_layer0.74160208
103MP0002269_muscular_atrophy0.73979831
104MP0000516_abnormal_urinary_system0.73796651
105MP0005367_renal/urinary_system_phenotyp0.73796651
106MP0002127_abnormal_cardiovascular_syste0.72418275
107MP0009053_abnormal_anal_canal0.70543028
108MP0000747_muscle_weakness0.70433219
109MP0001849_ear_inflammation0.69229617
110MP0003137_abnormal_impulse_conducting0.67573572
111MP0002113_abnormal_skeleton_development0.65708797
112MP0001348_abnormal_lacrimal_gland0.65232397
113MP0003300_gastrointestinal_ulcer0.65172633
114MP0005390_skeleton_phenotype0.64325057
115MP0001175_abnormal_lung_morphology0.64081719
116MP0002998_abnormal_bone_remodeling0.64070799
117* MP0004085_abnormal_heartbeat0.63766013
118MP0005197_abnormal_uvea_morphology0.63620712
119MP0000762_abnormal_tongue_morphology0.62873071
120MP0003868_abnormal_feces_composition0.61976729
121MP0000432_abnormal_head_morphology0.59313608
122MP0000538_abnormal_urinary_bladder0.58874341
123MP0002971_abnormal_brown_adipose0.58630203
124MP0008004_abnormal_stomach_pH0.57610360

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.49277646
2Premature rupture of membranes (HP:0001788)5.65419632
3Broad metatarsal (HP:0001783)5.08759924
4Ankle contracture (HP:0006466)5.07744088
5Cerebral aneurysm (HP:0004944)4.74774657
6Aortic dissection (HP:0002647)4.68360012
7Atrophic scars (HP:0001075)4.06524578
8Type 1 muscle fiber predominance (HP:0003803)4.06166534
9Shallow orbits (HP:0000586)4.03737318
10Increased connective tissue (HP:0009025)3.93641386
11Aortic aneurysm (HP:0004942)3.82792384
12Wrist flexion contracture (HP:0001239)3.78411160
13Spinal rigidity (HP:0003306)3.76256566
14Soft skin (HP:0000977)3.68517721
15Follicular hyperkeratosis (HP:0007502)3.55334363
16Fragile skin (HP:0001030)3.44593690
17Bladder diverticulum (HP:0000015)3.43560519
18Mitral valve prolapse (HP:0001634)3.39467674
19Overgrowth (HP:0001548)3.28513889
20Muscle fiber splitting (HP:0003555)3.18399960
21Dilatation of the ascending aorta (HP:0005111)3.17043752
22Increased variability in muscle fiber diameter (HP:0003557)3.16826642
23Vertebral compression fractures (HP:0002953)2.90100973
24Cervical subluxation (HP:0003308)2.77770663
25Aneurysm (HP:0002617)2.77703260
26Mildly elevated creatine phosphokinase (HP:0008180)2.75579072
27Peritonitis (HP:0002586)2.74930982
28Blue sclerae (HP:0000592)2.74508760
29Abnormality of skeletal muscle fiber size (HP:0012084)2.73315287
30Sudden death (HP:0001699)2.70617954
31Right ventricular cardiomyopathy (HP:0011663)2.70586479
32Slender build (HP:0001533)2.70429156
33Aortic regurgitation (HP:0001659)2.67120775
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.64329222
35Short 4th metacarpal (HP:0010044)2.64329222
36* Lipoatrophy (HP:0100578)2.63115822
37Ventricular tachycardia (HP:0004756)2.62910694
38Aortic valve stenosis (HP:0001650)2.59175728
39Wormian bones (HP:0002645)2.58377698
40Hip contracture (HP:0003273)2.57352227
41Genu recurvatum (HP:0002816)2.57334904
42Lymphangioma (HP:0100764)2.50732576
43Ectopia lentis (HP:0001083)2.50538719
44Hyporeflexia of lower limbs (HP:0002600)2.49424051
45Abnormality of dentin (HP:0010299)2.47935721
46Neonatal short-limb short stature (HP:0008921)2.40157351
47Hypoplasia of the iris (HP:0007676)2.38243395
48Hyperextensible skin (HP:0000974)2.37048383
49Striae distensae (HP:0001065)2.36025837
50Abnormality of the 4th metacarpal (HP:0010012)2.35615377
51Limited hip movement (HP:0008800)2.28525060
52Joint laxity (HP:0001388)2.25498136
53Thin bony cortex (HP:0002753)2.25321181
54Hypoventilation (HP:0002791)2.24983046
55Wide anterior fontanel (HP:0000260)2.24967252
56Abnormal delivery (HP:0001787)2.21584997
57Asymmetry of the thorax (HP:0001555)2.20382886
58Broad ribs (HP:0000885)2.20357470
59Difficulty running (HP:0009046)2.19291324
60Atrial fibrillation (HP:0005110)2.18220547
61Mitral stenosis (HP:0001718)2.15546563
62Camptodactyly of toe (HP:0001836)2.14657844
63Vascular tortuosity (HP:0004948)2.14423233
64Joint stiffness (HP:0001387)2.14411293
65Abnormality of the calf musculature (HP:0001430)2.13177372
66Coronal craniosynostosis (HP:0004440)2.12061034
67Myotonia (HP:0002486)2.10422697
68Ulnar claw (HP:0001178)2.09391684
69Venous abnormality (HP:0002624)2.09235675
70Hypoplastic ischia (HP:0003175)2.07602038
71Pulmonary artery stenosis (HP:0004415)2.06024503
72Round ear (HP:0100830)2.05256813
73Mild short stature (HP:0003502)2.03875389
74Supraventricular arrhythmia (HP:0005115)2.03120673
75Venous insufficiency (HP:0005293)2.02694026
76Bowel diverticulosis (HP:0005222)1.99351047
77Buphthalmos (HP:0000557)1.99111765
78Osteolytic defects of the phalanges of the hand (HP:0009771)1.99044130
79Osteolytic defects of the hand bones (HP:0009699)1.99044130
80Abnormality of the acetabulum (HP:0003170)1.98343928
81Primary atrial arrhythmia (HP:0001692)1.97889096
82Protruding ear (HP:0000411)1.97750624
83Arterial tortuosity (HP:0005116)1.97463812
84Joint contractures involving the joints of the feet (HP:0100492)1.96766523
85Flexion contracture of toe (HP:0005830)1.96766523
86Scapular winging (HP:0003691)1.96330136
87Disproportionate tall stature (HP:0001519)1.94448049
88Subaortic stenosis (HP:0001682)1.92169721
89Abnormality of the left ventricular outflow tract (HP:0011103)1.92169721
90Mitral regurgitation (HP:0001653)1.89052048
91Abnormality of the ischium (HP:0003174)1.88911077
92Polycythemia (HP:0001901)1.87102787
93Inguinal hernia (HP:0000023)1.87009776
94Osteoarthritis (HP:0002758)1.85233446
95Short nail (HP:0001799)1.85135846
96Ulnar bowing (HP:0003031)1.84977993
97Spondylolisthesis (HP:0003302)1.84824680
98Subacute progressive viral hepatitis (HP:0006572)1.84746047
99Supraventricular tachycardia (HP:0004755)1.84689912
100High pitched voice (HP:0001620)1.84061434
101Enlarged penis (HP:0000040)1.83471487
102Ovoid vertebral bodies (HP:0003300)1.82799184
103Elbow flexion contracture (HP:0002987)1.82166540
104Hematochezia (HP:0002573)1.81665976
105Breech presentation (HP:0001623)1.81188117
106Rectal prolapse (HP:0002035)1.81146538
107Increased corneal curvature (HP:0100692)1.80068097
108Keratoconus (HP:0000563)1.80068097
109Neonatal death (HP:0003811)1.78926444
110Exercise-induced muscle cramps (HP:0003710)1.78814550
111Coxa vara (HP:0002812)1.77904299
112Absent frontal sinuses (HP:0002688)1.76983233
113Nonimmune hydrops fetalis (HP:0001790)1.75745276
114Long toe (HP:0010511)1.75378739
115Infantile muscular hypotonia (HP:0008947)1.74062352
116Biconcave vertebral bodies (HP:0004586)1.73962038
117Delayed closure of the anterior fontanelle (HP:0001476)1.73165938
118Abnormality of the anterior chamber (HP:0000593)1.73083736
119Spontaneous hematomas (HP:0007420)1.72620525
120Acanthosis nigricans (HP:0000956)1.70901182
121Skull defect (HP:0001362)1.70858857
122Knee flexion contracture (HP:0006380)1.69236141
123Delayed cranial suture closure (HP:0000270)1.68617128
124Esophageal varix (HP:0002040)1.67451349
125Persistence of primary teeth (HP:0006335)1.66391093
126Conjunctival telangiectasia (HP:0000524)1.65871796
127Gingival overgrowth (HP:0000212)1.63270114
128Generalized amyotrophy (HP:0003700)1.63015190
129Osteopenia (HP:0000938)1.62968142
130Thoracolumbar scoliosis (HP:0002944)1.61562389

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.66287308
2TRIB33.94972084
3TTN3.53544122
4PKN23.01189317
5PDGFRA2.92923159
6LATS12.91678459
7DDR22.83526053
8SIK12.72338779
9KDR2.53191565
10RIPK12.46405078
11DMPK2.42932588
12MYLK2.35887417
13TGFBR22.26703425
14CAMK1D2.24684438
15EPHB22.18070498
16LMTK21.85897589
17CAMK1G1.74609916
18PTK2B1.71843693
19SCYL21.64276538
20PIK3CA1.55158474
21FRK1.53131018
22PTK61.48443463
23FER1.48388917
24LATS21.46047171
25FGFR21.44961641
26OBSCN1.37997795
27KIT1.35397290
28MET1.34726508
29PIK3CG1.33910370
30PDK31.29552718
31PDK41.29552718
32EPHA31.28228708
33PDGFRB1.23921016
34AKT31.23067101
35PAK21.20359993
36MOS1.19845952
37ERN11.18937868
38ILK1.18876836
39TGFBR11.17771420
40STK31.13227066
41ERBB41.08175465
42FGFR31.06857533
43ROCK11.05618680
44PTK21.04061985
45EPHB11.02811937
46FGFR10.98927201
47ABL20.98225981
48PAK40.97516948
49LRRK20.97286707
50NEK90.96391810
51STK380.95566629
52TESK10.95528222
53INSRR0.95484945
54PRKD30.95075790
55PDK20.91657366
56MTOR0.91489168
57LIMK10.91464764
58RET0.91054979
59PRKD10.88244760
60STK38L0.87599741
61STK240.87115271
62BMX0.86298778
63GRK10.83338637
64GRK50.81662660
65PHKG20.81422016
66PHKG10.81422016
67TRPM70.81161347
68MST1R0.80528540
69FLT30.79712734
70PAK30.79244411
71RPS6KA20.78849365
72MAP3K60.78761764
73NUAK10.76497361
74MAPKAPK30.75251024
75PRKAA20.74718209
76MAP3K100.69416717
77PRKCH0.65020605
78PAK60.64171425
79NLK0.61652528
80FGFR40.60168597
81PRKG20.58290067
82CDC42BPA0.57022793
83GSK3A0.55448234
84MAP2K10.53027269
85ICK0.50699378
86ROCK20.50515924
87ZAK0.50086271
88CDK60.49664763
89INSR0.47138776
90JAK10.46315050
91WNK10.45903417
92BCKDK0.45395223
93IGF1R0.44849217
94SRC0.44575557
95CDK80.44022685
96FES0.42517918
97PRKAA10.41442374
98MAP3K30.40762053
99MAP3K70.39609139
100TEC0.39589967
101MARK20.39421566
102EEF2K0.39406765
103PRKCE0.38988557
104DAPK30.38898134
105PDPK10.38203067
106MAPK40.37796603
107NEK10.37770436
108MAPK120.36352001
109ERBB20.35264381
110CAMK10.34670787
111MAP2K30.33741103
112MARK10.33639718
113PRKD20.31622909
114MELK0.29807155
115ZAP700.29107244
116NTRK10.27174583
117CAMK40.26934961
118ADRBK10.26900960
119CAMK2G0.26208674
120CDK90.25974679
121MAPK150.24734551
122MAPKAPK50.24480568
123PRKG10.24347080
124ABL10.24113095
125WNK40.22597549
126MAPK70.22347293
127PLK20.21349812
128CSK0.20240068
129MARK30.18236007
130AKT20.17272899

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045124.45696632
2* Focal adhesion_Homo sapiens_hsa045103.01533349
3Dilated cardiomyopathy_Homo sapiens_hsa054142.95036087
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.86550252
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.70861840
6Protein digestion and absorption_Homo sapiens_hsa049742.67024699
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.58778092
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.40899879
9Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.33772869
10Adherens junction_Homo sapiens_hsa045202.26039838
11Viral myocarditis_Homo sapiens_hsa054161.94400623
12* Small cell lung cancer_Homo sapiens_hsa052221.88440501
13* Amoebiasis_Homo sapiens_hsa051461.88256429
14Proteoglycans in cancer_Homo sapiens_hsa052051.87785353
15PPAR signaling pathway_Homo sapiens_hsa033201.80533875
16Propanoate metabolism_Homo sapiens_hsa006401.78097258
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.73160581
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69952209
19Fatty acid metabolism_Homo sapiens_hsa012121.60078579
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.52747021
21Fatty acid degradation_Homo sapiens_hsa000711.51062144
22* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.46948562
23Fatty acid biosynthesis_Homo sapiens_hsa000611.42209687
24Insulin resistance_Homo sapiens_hsa049311.35857972
25TGF-beta signaling pathway_Homo sapiens_hsa043501.33592802
26Complement and coagulation cascades_Homo sapiens_hsa046101.28632112
27Tight junction_Homo sapiens_hsa045301.27887916
28Basal cell carcinoma_Homo sapiens_hsa052171.27373179
29Hippo signaling pathway_Homo sapiens_hsa043901.24899079
30MicroRNAs in cancer_Homo sapiens_hsa052061.23559578
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23054112
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.22566528
33AMPK signaling pathway_Homo sapiens_hsa041521.22239407
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15640935
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.14731979
36Platelet activation_Homo sapiens_hsa046111.08793166
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08597184
38Prion diseases_Homo sapiens_hsa050201.07355385
39* Pathways in cancer_Homo sapiens_hsa052001.02026794
40Melanoma_Homo sapiens_hsa052181.00641703
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00416084
42Chronic myeloid leukemia_Homo sapiens_hsa052201.00187117
43Hedgehog signaling pathway_Homo sapiens_hsa043400.99932610
44Axon guidance_Homo sapiens_hsa043600.99081340
45Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98829233
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.97965976
47Rap1 signaling pathway_Homo sapiens_hsa040150.97297399
48Insulin signaling pathway_Homo sapiens_hsa049100.97196884
49* Toxoplasmosis_Homo sapiens_hsa051450.91907928
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91586942
51Lysine degradation_Homo sapiens_hsa003100.91061195
52Bladder cancer_Homo sapiens_hsa052190.90081432
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89363072
54Malaria_Homo sapiens_hsa051440.88919414
55HIF-1 signaling pathway_Homo sapiens_hsa040660.88681248
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.86985982
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85594801
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84569340
59Prostate cancer_Homo sapiens_hsa052150.84374773
60Renal cell carcinoma_Homo sapiens_hsa052110.83494796
61Glioma_Homo sapiens_hsa052140.82808918
62Glucagon signaling pathway_Homo sapiens_hsa049220.81916819
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81154607
64Cardiac muscle contraction_Homo sapiens_hsa042600.77571565
65Renin secretion_Homo sapiens_hsa049240.76612103
66Endometrial cancer_Homo sapiens_hsa052130.76075563
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76002607
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75136793
69Melanogenesis_Homo sapiens_hsa049160.72533697
70Notch signaling pathway_Homo sapiens_hsa043300.71759929
71Pancreatic cancer_Homo sapiens_hsa052120.71277849
72Other glycan degradation_Homo sapiens_hsa005110.70179446
73Carbon metabolism_Homo sapiens_hsa012000.69652949
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69467751
75Dorso-ventral axis formation_Homo sapiens_hsa043200.69169402
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66708848
77Estrogen signaling pathway_Homo sapiens_hsa049150.65380094
78Wnt signaling pathway_Homo sapiens_hsa043100.64775474
79Pertussis_Homo sapiens_hsa051330.63933183
80Thyroid cancer_Homo sapiens_hsa052160.62628413
81Ovarian steroidogenesis_Homo sapiens_hsa049130.61804297
82Pyruvate metabolism_Homo sapiens_hsa006200.61179307
83mTOR signaling pathway_Homo sapiens_hsa041500.60931044
84Calcium signaling pathway_Homo sapiens_hsa040200.60592338
85Glycerolipid metabolism_Homo sapiens_hsa005610.59023057
86Gap junction_Homo sapiens_hsa045400.58640931
87Colorectal cancer_Homo sapiens_hsa052100.58344579
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58342842
89HTLV-I infection_Homo sapiens_hsa051660.53574675
90VEGF signaling pathway_Homo sapiens_hsa043700.52497405
91ABC transporters_Homo sapiens_hsa020100.52408319
92FoxO signaling pathway_Homo sapiens_hsa040680.50302736
93Ras signaling pathway_Homo sapiens_hsa040140.50247188
94MAPK signaling pathway_Homo sapiens_hsa040100.50191479
95Choline metabolism in cancer_Homo sapiens_hsa052310.48982744
96Gastric acid secretion_Homo sapiens_hsa049710.48923260
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.46267573
98Cocaine addiction_Homo sapiens_hsa050300.45621639
99cAMP signaling pathway_Homo sapiens_hsa040240.45494201
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45225943
101Type II diabetes mellitus_Homo sapiens_hsa049300.44967608
102Oxytocin signaling pathway_Homo sapiens_hsa049210.44640698
103Renin-angiotensin system_Homo sapiens_hsa046140.43528841
104Salivary secretion_Homo sapiens_hsa049700.43408475
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42425863
106Fat digestion and absorption_Homo sapiens_hsa049750.41942706
107TNF signaling pathway_Homo sapiens_hsa046680.41825971
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41442025
109Sulfur metabolism_Homo sapiens_hsa009200.40600485
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39715588
111Starch and sucrose metabolism_Homo sapiens_hsa005000.38682720
112Thyroid hormone synthesis_Homo sapiens_hsa049180.38216741
113Lysosome_Homo sapiens_hsa041420.38159611
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37352805
115GnRH signaling pathway_Homo sapiens_hsa049120.36621967
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.36466445
117Circadian entrainment_Homo sapiens_hsa047130.35809458
118Caffeine metabolism_Homo sapiens_hsa002320.35288246
119Cholinergic synapse_Homo sapiens_hsa047250.34905584
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33902648
121Endocytosis_Homo sapiens_hsa041440.32858189
122Glutamatergic synapse_Homo sapiens_hsa047240.32245935
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29470093
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26441116
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24668606

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