LAMA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.58486908
2regulation of hippo signaling (GO:0035330)5.19977492
3regulation of gene silencing by miRNA (GO:0060964)5.03581204
4regulation of gene silencing by RNA (GO:0060966)5.03581204
5regulation of posttranscriptional gene silencing (GO:0060147)5.03581204
6semaphorin-plexin signaling pathway (GO:0071526)4.76787465
7paraxial mesoderm development (GO:0048339)4.58954597
8establishment of apical/basal cell polarity (GO:0035089)4.58943321
9polarized epithelial cell differentiation (GO:0030859)4.55118590
10activation of Rac GTPase activity (GO:0032863)4.37572958
11epithelial cell-cell adhesion (GO:0090136)4.19134341
12plasma membrane repair (GO:0001778)4.19049000
13bundle of His cell to Purkinje myocyte communication (GO:0086069)4.13060609
14basement membrane organization (GO:0071711)4.13011071
15hippo signaling (GO:0035329)4.08703400
16lung epithelium development (GO:0060428)4.03712887
17* cell-substrate junction assembly (GO:0007044)3.92353979
18positive regulation of SMAD protein import into nucleus (GO:0060391)3.87537094
19COPI coating of Golgi vesicle (GO:0048205)3.86073896
20Golgi transport vesicle coating (GO:0048200)3.86073896
21establishment or maintenance of monopolar cell polarity (GO:0061339)3.79386784
22establishment of monopolar cell polarity (GO:0061162)3.79386784
23regulation of SMAD protein import into nucleus (GO:0060390)3.71353005
24renal filtration (GO:0097205)3.65339823
25cytoskeletal anchoring at plasma membrane (GO:0007016)3.64894153
26apoptotic process involved in morphogenesis (GO:0060561)3.63215063
27cell migration involved in sprouting angiogenesis (GO:0002042)3.49983470
28dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.46919641
29regulation of cholesterol biosynthetic process (GO:0045540)3.44828339
30regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.44621058
31* adherens junction assembly (GO:0034333)3.37674578
32glomerular visceral epithelial cell development (GO:0072015)3.34697440
33mesodermal cell differentiation (GO:0048333)3.31920437
34glomerular basement membrane development (GO:0032836)3.31907948
35cell-cell junction maintenance (GO:0045217)3.31564629
36desmosome organization (GO:0002934)3.28338105
37endothelial cell chemotaxis (GO:0035767)3.26995104
38regulation of water loss via skin (GO:0033561)3.25001694
39nuclear pore complex assembly (GO:0051292)3.24540471
40Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.24307012
41negative regulation of cell size (GO:0045792)3.21417500
42vascular endothelial growth factor signaling pathway (GO:0038084)3.19302552
43nuclear pore organization (GO:0006999)3.17893933
44maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.17853369
45heterochromatin organization (GO:0070828)3.11198558
46protein retention in ER lumen (GO:0006621)3.10860649
47negative regulation of cell fate specification (GO:0009996)3.10781388
48regulation of translational fidelity (GO:0006450)3.10549501
49blood vessel endothelial cell migration (GO:0043534)3.09102225
50lung-associated mesenchyme development (GO:0060484)3.07161218
51cell adhesion mediated by integrin (GO:0033627)3.06478333
52regulation of establishment of planar polarity (GO:0090175)3.05593903
53glomerular epithelial cell development (GO:0072310)3.05069563
54anterior/posterior axis specification, embryo (GO:0008595)3.05007100
55regulation of cholesterol homeostasis (GO:2000188)3.04706994
56insulin-like growth factor receptor signaling pathway (GO:0048009)3.03468344
57pre-miRNA processing (GO:0031054)3.02457060
58regulation of cardioblast differentiation (GO:0051890)3.01280954
59wound healing, spreading of epidermal cells (GO:0035313)3.00898796
60retina vasculature morphogenesis in camera-type eye (GO:0061299)2.95929503
61lymphangiogenesis (GO:0001946)2.95749650
62retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.95417803
63establishment of skin barrier (GO:0061436)2.92383444
64establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.91560034
65endothelial cell morphogenesis (GO:0001886)2.91507852
66gap junction assembly (GO:0016264)2.90594485
67convergent extension (GO:0060026)2.89468576
68regulation of cell fate specification (GO:0042659)2.89101786
69planar cell polarity pathway involved in neural tube closure (GO:0090179)2.88372012
70endodermal cell differentiation (GO:0035987)2.87267298
71surfactant homeostasis (GO:0043129)2.86901881
72trophectodermal cell differentiation (GO:0001829)2.86049832
73ear development (GO:0043583)2.83621581
74embryonic foregut morphogenesis (GO:0048617)2.83611345
75interferon-gamma secretion (GO:0072643)2.82643232
76embryonic camera-type eye development (GO:0031076)2.82591734
77* cell-substrate adherens junction assembly (GO:0007045)2.81447867
78* focal adhesion assembly (GO:0048041)2.81447867
79regulation of glucose import in response to insulin stimulus (GO:2001273)2.78524858
80regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.78403835
81sarcomere organization (GO:0045214)2.78378572
82mRNA transcription (GO:0009299)2.78214415
83non-canonical Wnt signaling pathway (GO:0035567)2.77936881
84cell junction maintenance (GO:0034331)2.77857040
85notochord development (GO:0030903)2.76858025
86asymmetric protein localization (GO:0008105)2.75045983
87negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.73438171
88regulation of tight junction assembly (GO:2000810)2.73246145
89apical protein localization (GO:0045176)2.70515089
90regulation of endothelial cell chemotaxis (GO:2001026)2.68077370
91bone remodeling (GO:0046849)2.67202001
92endothelial tube morphogenesis (GO:0061154)2.65456902
93morphogenesis of an endothelium (GO:0003159)2.65456902
94regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.65275421
95neural tube development (GO:0021915)2.64973284
96regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.64590387
97establishment or maintenance of apical/basal cell polarity (GO:0035088)2.64452286
98establishment or maintenance of bipolar cell polarity (GO:0061245)2.64452286
99maternal placenta development (GO:0001893)2.64185059
100cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.63844766
101mRNA transcription from RNA polymerase II promoter (GO:0042789)2.63511170
102positive regulation of Cdc42 GTPase activity (GO:0043089)2.62408001
103negative regulation of chondrocyte differentiation (GO:0032331)2.62253908
104apoptotic process involved in development (GO:1902742)2.62193207
105cell migration involved in gastrulation (GO:0042074)2.62157536
106cell surface receptor signaling pathway involved in heart development (GO:0061311)2.61499571
107renal system development (GO:0072001)2.61179013
108collecting duct development (GO:0072044)2.60825495
109* adherens junction organization (GO:0034332)2.59575055
110vasculogenesis (GO:0001570)2.59533697
111receptor catabolic process (GO:0032801)2.57572549
112cardiac myofibril assembly (GO:0055003)2.56731574
113* cell junction assembly (GO:0034329)2.56342425
114positive regulation of endothelial cell apoptotic process (GO:2000353)2.55895159
115regulation of transforming growth factor beta2 production (GO:0032909)2.55616714
116multicellular organismal water homeostasis (GO:0050891)2.55403930
117heart valve morphogenesis (GO:0003179)2.55194857
118negative regulation of fatty acid transport (GO:2000192)2.53489019
119positive regulation of histone deacetylation (GO:0031065)2.53405486
120positive regulation of receptor recycling (GO:0001921)2.52929679
121atrioventricular valve morphogenesis (GO:0003181)2.52782549
122vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.52266432
123mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.51111505
124* branching involved in salivary gland morphogenesis (GO:0060445)2.50784773
125cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.50576362
126cell volume homeostasis (GO:0006884)2.48763959
127embryonic eye morphogenesis (GO:0048048)2.47802927
128glomerular filtration (GO:0003094)2.47653305
129establishment of epithelial cell polarity (GO:0090162)2.47278076
130embryonic retina morphogenesis in camera-type eye (GO:0060059)2.46802756
131positive regulation of osteoblast proliferation (GO:0033690)2.45379305
132positive regulation of protein kinase C signaling (GO:0090037)2.45230929
133* cell junction organization (GO:0034330)2.45157470
134epithelial cell differentiation involved in prostate gland development (GO:0060742)2.44600796
135proline biosynthetic process (GO:0006561)2.44209979
136ectoderm development (GO:0007398)2.42706883
137intestinal epithelial cell development (GO:0060576)2.42530671
138branching involved in mammary gland duct morphogenesis (GO:0060444)2.42092080
139bone morphogenesis (GO:0060349)2.41780861
140labyrinthine layer blood vessel development (GO:0060716)2.41651080
141regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.41538958
142patterning of blood vessels (GO:0001569)2.40163754
143positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.39918062
144morphogenesis of an epithelial sheet (GO:0002011)2.39033692
145skin development (GO:0043588)2.38926561
146regulation of G0 to G1 transition (GO:0070316)2.38688322
147negative regulation of catenin import into nucleus (GO:0035414)2.38381101
148positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.37993809
149negative regulation of cartilage development (GO:0061037)2.37658713
150glucose catabolic process (GO:0006007)2.37575664
151regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.37536626
152cell-cell junction assembly (GO:0007043)2.36494449
153positive regulation of catenin import into nucleus (GO:0035413)2.34523305
154positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.34200523
155pore complex assembly (GO:0046931)2.33163207
156mitotic nuclear envelope disassembly (GO:0007077)2.31653972
157regulation of gene silencing (GO:0060968)2.31607475

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.22802428
2E2F7_22180533_ChIP-Seq_HELA_Human3.03494867
3FOXM1_23109430_ChIP-Seq_U2OS_Human2.96530101
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.95547439
5NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.76301214
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66173374
7POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.62784304
8LXR_22292898_ChIP-Seq_THP-1_Human2.57763972
9* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.55717210
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.54446134
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.54446134
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.54446134
13* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.48647744
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.48265037
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.44587033
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.42032646
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.41212263
18ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.31235976
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.28471704
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.28237731
21CLOCK_20551151_ChIP-Seq_293T_Human2.22681963
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.19835508
23HIF1A_21447827_ChIP-Seq_MCF-7_Human2.17146892
24* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.12899308
25* ZNF263_19887448_ChIP-Seq_K562_Human2.08727615
26ERG_21242973_ChIP-ChIP_JURKAT_Human2.00444475
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.97576588
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.97103031
29* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.96825098
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.93381678
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.93259170
32* ELK3_25401928_ChIP-Seq_HUVEC_Human1.90968257
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.85875997
34* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.81160012
35SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.79842755
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.79343708
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.76715386
38AR_21909140_ChIP-Seq_LNCAP_Human1.71729163
39RACK7_27058665_Chip-Seq_MCF-7_Human1.71104271
40ATF3_27146783_Chip-Seq_COLON_Human1.70545753
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.69796474
42NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.66852712
43* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.65418748
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63374016
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62517020
46* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.61818765
47* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.60350307
48* SMC4_20622854_ChIP-Seq_HELA_Human1.59076562
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53946180
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51198864
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49546843
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48370469
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48014402
54* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.47850246
55P68_20966046_ChIP-Seq_HELA_Human1.47343796
56CREB1_26743006_Chip-Seq_LNCaP_Human1.45565721
57* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.43633751
58* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.43633751
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.43127359
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42986642
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42405611
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42081183
63P63_26484246_Chip-Seq_KERATINOCYTES_Human1.39595048
64* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39393142
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39101524
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38088273
67TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35672095
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32594927
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32333911
70KDM2B_26808549_Chip-Seq_DND41_Human1.32311381
71POU5F1_16518401_ChIP-PET_MESCs_Mouse1.32144085
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.32103616
73* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32098454
74MYC_22102868_ChIP-Seq_BL_Human1.32005934
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31533681
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.31155214
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30135963
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29732953
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28983613
80RUNX1_27514584_Chip-Seq_MCF-7_Human1.28979279
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.28806487
82EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.28635775
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28593753
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.28422908
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27621046
86VDR_21846776_ChIP-Seq_THP-1_Human1.26783433
87ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26473666
88* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24805923
89* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23849487
90CTCF_27219007_Chip-Seq_Bcells_Human1.22709784
91SOX2_18692474_ChIP-Seq_MEFs_Mouse1.21847384
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21710429
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21225374
94KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20193059
95GATA6_25053715_ChIP-Seq_YYC3_Human1.19820294
96* KLF5_25053715_ChIP-Seq_YYC3_Human1.19608033
97* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.19202048
98* TBX20_22328084_ChIP-Seq_HEART_Mouse1.17418595
99* TBX20_22080862_ChIP-Seq_HEART_Mouse1.17418595
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.17276527
101TET1_21490601_ChIP-Seq_MESCs_Mouse1.16875941
102CDX2_20551321_ChIP-Seq_CACO-2_Human1.16573821
103CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16080022
104* TP63_22573176_ChIP-Seq_HFKS_Human1.16055871
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14882005
106* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.14870915
107SA1_27219007_Chip-Seq_ERYTHROID_Human1.14859647
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14202782
109PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.14077658
110* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13182050
111* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12707582
112UBF1/2_26484160_Chip-Seq_HMECs_Human1.12627802
113TCF7_22412390_ChIP-Seq_EML_Mouse1.12541638
114* KDM2B_26808549_Chip-Seq_K562_Human1.12484435
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12445850
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11988063
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11097998
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10891544
119TP53_22127205_ChIP-Seq_IMR90_Human1.10126004
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09199544
121SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07755789
122EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07606340
123* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07523294
124RXR_22158963_ChIP-Seq_LIVER_Mouse1.07223173
125KDM2B_26808549_Chip-Seq_JURKAT_Human1.07207576
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06970421
127NANOG_21062744_ChIP-ChIP_HESCs_Human1.06497931
128NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05744715
129SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05401272
130FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05136132
131* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.04195938
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04134063
133KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04040912
134SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03990035
135ISL1_27105846_Chip-Seq_CPCs_Mouse1.03050578
136* TP53_23651856_ChIP-Seq_MEFs_Mouse0.97114423
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96892213
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95175403
139* NCOR1_26117541_ChIP-Seq_K562_Human0.93548865
140RARB_24833708_ChIP-Seq_LIVER_Mouse0.93070555
141SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.91885817

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane4.39582051
2MP0000566_synostosis4.35436770
3MP0003705_abnormal_hypodermis_morpholog3.89316033
4MP0000579_abnormal_nail_morphology3.69694240
5MP0010234_abnormal_vibrissa_follicle2.99980389
6MP0005623_abnormal_meninges_morphology2.86575261
7MP0003941_abnormal_skin_development2.81757202
8MP0000537_abnormal_urethra_morphology2.70149261
9MP0003566_abnormal_cell_adhesion2.52382888
10MP0005409_darkened_coat_color2.52178901
11MP0010352_gastrointestinal_tract_polyps2.46153705
12MP0010368_abnormal_lymphatic_system2.42885855
13MP0004084_abnormal_cardiac_muscle2.32425505
14MP0003279_aneurysm2.30468842
15MP0004858_abnormal_nervous_system2.17966635
16MP0002098_abnormal_vibrissa_morphology2.11790192
17MP0008438_abnormal_cutaneous_collagen2.06714609
18MP0005275_abnormal_skin_tensile2.06539687
19MP0002249_abnormal_larynx_morphology1.96042368
20MP0010030_abnormal_orbit_morphology1.94456614
21MP0001849_ear_inflammation1.90029421
22MP0000678_abnormal_parathyroid_gland1.79492102
23MP0005076_abnormal_cell_differentiation1.78769235
24MP0001348_abnormal_lacrimal_gland1.74619350
25MP0005257_abnormal_intraocular_pressure1.62458887
26MP0009780_abnormal_chondrocyte_physiolo1.62369159
27MP0004145_abnormal_muscle_electrophysio1.47912463
28MP0005670_abnormal_white_adipose1.47046313
29MP0003283_abnormal_digestive_organ1.46470015
30MP0000733_abnormal_muscle_development1.46436620
31MP0002796_impaired_skin_barrier1.45952256
32MP0000750_abnormal_muscle_regeneration1.45465426
33MP0000003_abnormal_adipose_tissue1.45407392
34MP0004782_abnormal_surfactant_physiolog1.44848649
35MP0002089_abnormal_postnatal_growth/wei1.43899262
36MP0001958_emphysema1.43551440
37MP0001216_abnormal_epidermal_layer1.42465468
38MP0010630_abnormal_cardiac_muscle1.41648033
39MP0009053_abnormal_anal_canal1.41399601
40MP0006054_spinal_hemorrhage1.41375833
41MP0005023_abnormal_wound_healing1.39453668
42MP0004264_abnormal_extraembryonic_tissu1.39115884
43MP0001879_abnormal_lymphatic_vessel1.38066176
44MP0002084_abnormal_developmental_patter1.37886279
45MP0003119_abnormal_digestive_system1.36871153
46MP0002697_abnormal_eye_size1.35527894
47MP0004087_abnormal_muscle_fiber1.34207005
48* MP0002086_abnormal_extraembryonic_tissu1.34199711
49MP0002925_abnormal_cardiovascular_devel1.33939250
50MP0003984_embryonic_growth_retardation1.33914875
51MP0001672_abnormal_embryogenesis/_devel1.33530550
52MP0005380_embryogenesis_phenotype1.33530550
53MP0002088_abnormal_embryonic_growth/wei1.32768420
54MP0004185_abnormal_adipocyte_glucose1.31553618
55MP0010678_abnormal_skin_adnexa1.30859351
56MP0004957_abnormal_blastocyst_morpholog1.30648070
57MP0000534_abnormal_ureter_morphology1.29490342
58MP0005501_abnormal_skin_physiology1.27947471
59* MP0004197_abnormal_fetal_growth/weight/1.27699341
60MP0005451_abnormal_body_composition1.26480604
61MP0005330_cardiomyopathy1.24942651
62MP0005058_abnormal_lysosome_morphology1.24800153
63* MP0002085_abnormal_embryonic_tissue1.24736693
64MP0006138_congestive_heart_failure1.24712538
65MP0001730_embryonic_growth_arrest1.24079743
66MP0010771_integument_phenotype1.23804161
67MP0003091_abnormal_cell_migration1.22785697
68MP0003828_pulmonary_edema1.20119356
69MP0000751_myopathy1.20082117
70MP0001915_intracranial_hemorrhage1.17814756
71MP0000377_abnormal_hair_follicle1.17137753
72MP0005167_abnormal_blood-brain_barrier1.17060789
73MP0000767_abnormal_smooth_muscle1.13669448
74MP0002653_abnormal_ependyma_morphology1.13501754
75MP0003567_abnormal_fetal_cardiomyocyte1.13445998
76MP0005375_adipose_tissue_phenotype1.13132070
77MP0002877_abnormal_melanocyte_morpholog1.12641152
78MP0000428_abnormal_craniofacial_morphol1.11805946
79MP0002060_abnormal_skin_morphology1.10792071
80* MP0001697_abnormal_embryo_size1.10581474
81MP0008260_abnormal_autophagy1.09683504
82* MP0003115_abnormal_respiratory_system1.09371652
83MP0005360_urolithiasis1.07748888
84MP0004381_abnormal_hair_follicle1.06615468
85MP0009278_abnormal_bone_marrow1.05637229
86MP0003453_abnormal_keratinocyte_physiol1.05433357
87MP0000013_abnormal_adipose_tissue1.04175785
88MP0003300_gastrointestinal_ulcer1.03165031
89MP0003950_abnormal_plasma_membrane1.01720096
90* MP0001614_abnormal_blood_vessel1.01598589
91MP0000762_abnormal_tongue_morphology1.01220803
92MP0004036_abnormal_muscle_relaxation1.00940034
93MP0000266_abnormal_heart_morphology1.00849931
94MP0008775_abnormal_heart_ventricle0.99980304
95MP0003123_paternal_imprinting0.99914269
96MP0003878_abnormal_ear_physiology0.99731907
97MP0005377_hearing/vestibular/ear_phenot0.99731907
98MP0002234_abnormal_pharynx_morphology0.99208986
99MP0004233_abnormal_muscle_weight0.98303707
100* MP0003935_abnormal_craniofacial_develop0.97774944
101MP0000467_abnormal_esophagus_morphology0.96528392
102MP0003385_abnormal_body_wall0.95925064
103MP0005508_abnormal_skeleton_morphology0.95215589
104MP0009384_cardiac_valve_regurgitation0.95008261
105MP0002108_abnormal_muscle_morphology0.94775448
106MP0002128_abnormal_blood_circulation0.94369056
107MP0000383_abnormal_hair_follicle0.94114703
108MP0000516_abnormal_urinary_system0.93813201
109MP0005367_renal/urinary_system_phenotyp0.93813201
110MP0003937_abnormal_limbs/digits/tail_de0.93688981
111MP0002269_muscular_atrophy0.92677348
112MP0002932_abnormal_joint_morphology0.92232074
113* MP0002080_prenatal_lethality0.91867355
114MP0000462_abnormal_digestive_system0.90240434
115MP0002282_abnormal_trachea_morphology0.90187269
116* MP0000350_abnormal_cell_proliferation0.89616074
117MP0002254_reproductive_system_inflammat0.88686070
118MP0002092_abnormal_eye_morphology0.88623809
119MP0002111_abnormal_tail_morphology0.88492161
120MP0001784_abnormal_fluid_regulation0.88376231
121MP0002896_abnormal_bone_mineralization0.87618709
122MP0009931_abnormal_skin_appearance0.87563109
123MP0001293_anophthalmia0.87366560
124* MP0003942_abnormal_urinary_system0.87132233
125MP0001544_abnormal_cardiovascular_syste0.86521074
126MP0005385_cardiovascular_system_phenoty0.86521074
127MP0009672_abnormal_birth_weight0.85691247
128* MP0000432_abnormal_head_morphology0.85498911
129MP0003111_abnormal_nucleus_morphology0.85312279
130MP0005666_abnormal_adipose_tissue0.83791032
131* MP0002116_abnormal_craniofacial_bone0.75198869
132MP0000627_abnormal_mammary_gland0.74470467
133MP0001340_abnormal_eyelid_morphology0.74079893
134MP0001299_abnormal_eye_distance/0.73245230
135MP0003755_abnormal_palate_morphology0.72796179
136MP0003172_abnormal_lysosome_physiology0.71271354
137MP0005083_abnormal_biliary_tract0.67035477

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.18089732
2Cerebral aneurysm (HP:0004944)4.17580313
3Wrist flexion contracture (HP:0001239)3.98735888
4Broad face (HP:0000283)3.96434157
5Right ventricular cardiomyopathy (HP:0011663)3.86909869
6Shallow orbits (HP:0000586)3.51486477
7Increased connective tissue (HP:0009025)3.50611785
8Hyperacusis (HP:0010780)3.40937051
9Milia (HP:0001056)3.33531053
10Atrophic scars (HP:0001075)3.33456820
11Skull defect (HP:0001362)3.32574223
12Pterygium (HP:0001059)3.23595481
13Vertebral clefting (HP:0008428)3.08622921
14Abnormal vertebral ossification (HP:0100569)3.05003156
15Ulnar bowing (HP:0003031)2.99687716
16Ankle contracture (HP:0006466)2.93198473
17Advanced eruption of teeth (HP:0006288)2.93183678
18Muscle fiber splitting (HP:0003555)2.88871098
19Radial bowing (HP:0002986)2.83840998
20Trismus (HP:0000211)2.82835927
21Neonatal death (HP:0003811)2.79925334
22Overgrowth (HP:0001548)2.79718909
23Spinal rigidity (HP:0003306)2.78099444
24Ventricular tachycardia (HP:0004756)2.77409156
25Neoplasm of the oral cavity (HP:0100649)2.74782895
26High pitched voice (HP:0001620)2.70561649
27Obstructive sleep apnea (HP:0002870)2.70316088
28Hip contracture (HP:0003273)2.68891358
29Difficulty climbing stairs (HP:0003551)2.68145233
30Hyporeflexia of lower limbs (HP:0002600)2.67950408
31Broad metatarsal (HP:0001783)2.57559793
32Premature rupture of membranes (HP:0001788)2.50560543
33Short 4th metacarpal (HP:0010044)2.50458748
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.50458748
35Selective tooth agenesis (HP:0001592)2.49265576
36Alopecia of scalp (HP:0002293)2.47514648
37Natal tooth (HP:0000695)2.46842361
38Aplasia of the phalanges of the hand (HP:0009802)2.45216815
39Aplasia involving bones of the extremities (HP:0009825)2.45216815
40Aplasia involving bones of the upper limbs (HP:0009823)2.45216815
41Aneurysm (HP:0002617)2.44271264
42Ankyloglossia (HP:0010296)2.43099963
43Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.35484057
44Short 1st metacarpal (HP:0010034)2.35484057
45Lymphangioma (HP:0100764)2.35037414
46Tracheal stenosis (HP:0002777)2.33154534
47Aortic aneurysm (HP:0004942)2.31748686
48Esophageal atresia (HP:0002032)2.31251069
49Onycholysis (HP:0001806)2.29863977
50Bowing of the arm (HP:0006488)2.29582709
51Bowed forearm bones (HP:0003956)2.29582709
52Abnormal hair laboratory examination (HP:0003328)2.25824822
53Ependymoma (HP:0002888)2.25452879
54Focal segmental glomerulosclerosis (HP:0000097)2.24992318
55Hemorrhage of the eye (HP:0011885)2.22544745
56Aplasia cutis congenita (HP:0001057)2.21186261
57Deep venous thrombosis (HP:0002625)2.20718890
58Difficulty running (HP:0009046)2.20642576
59Plantar hyperkeratosis (HP:0007556)2.19938286
60Asymmetry of the thorax (HP:0001555)2.19579257
61Mesangial abnormality (HP:0001966)2.12270904
62Short phalanx of the thumb (HP:0009660)2.11993294
63Short nail (HP:0001799)2.10862959
64Aortic dissection (HP:0002647)2.10075424
65Abnormality of oral frenula (HP:0000190)2.09484820
66Fragile skin (HP:0001030)2.09314727
67J-shaped sella turcica (HP:0002680)2.07535477
68Abnormality of the 4th metacarpal (HP:0010012)2.06480582
69Fused cervical vertebrae (HP:0002949)2.04902683
70Hypoplasia of dental enamel (HP:0006297)2.04804828
71Astrocytoma (HP:0009592)2.03536025
72Abnormality of the astrocytes (HP:0100707)2.03536025
73Abnormality of the 1st metacarpal (HP:0010009)2.03530087
74Rectal prolapse (HP:0002035)2.02487663
75Myotonia (HP:0002486)2.01111734
76Short humerus (HP:0005792)2.00937897
77Abnormality of the distal phalanges of the toes (HP:0010182)2.00476416
78Hypotrichosis (HP:0001006)1.99264717
79Arterial tortuosity (HP:0005116)1.98030684
80Mitral valve prolapse (HP:0001634)1.98002557
81Urethral obstruction (HP:0000796)1.96027892
82Long palpebral fissure (HP:0000637)1.95646989
83Missing ribs (HP:0000921)1.93608148
84Sudden death (HP:0001699)1.92836831
85Lower limb amyotrophy (HP:0007210)1.92458028
86Pili torti (HP:0003777)1.92202070
87Long eyelashes (HP:0000527)1.91802491
88Bladder diverticulum (HP:0000015)1.91457951
89Fragile nails (HP:0001808)1.91027029
90Laryngomalacia (HP:0001601)1.88412618
91Cervical subluxation (HP:0003308)1.87713443
92Abnormality of the salivary glands (HP:0010286)1.87161872
93Distal lower limb muscle weakness (HP:0009053)1.87057919
94Acanthosis nigricans (HP:0000956)1.86842870
95Lip pit (HP:0100267)1.84937357
96Aplasia/hypoplasia of the humerus (HP:0006507)1.84772380
97Limited hip movement (HP:0008800)1.84751266
98Round ear (HP:0100830)1.84526127
99Glomerulosclerosis (HP:0000096)1.83705961
100Disproportionate tall stature (HP:0001519)1.83622035
101Stridor (HP:0010307)1.82335438
102Turricephaly (HP:0000262)1.82223126
103Thick nail (HP:0001805)1.82140023
104Scapular winging (HP:0003691)1.80962632
105Mildly elevated creatine phosphokinase (HP:0008180)1.80490343
106Nasolacrimal duct obstruction (HP:0000579)1.80008572
107Nail dystrophy (HP:0008404)1.79599013
108Thin bony cortex (HP:0002753)1.79380074
109Premature skin wrinkling (HP:0100678)1.79169908
110Oligodontia (HP:0000677)1.78120323
111Biconcave vertebral bodies (HP:0004586)1.77799036
112Upper limb amyotrophy (HP:0009129)1.77771979
113Distal upper limb amyotrophy (HP:0007149)1.77771979
114Nuclear cataract (HP:0100018)1.77479446
115Absent eyelashes (HP:0000561)1.76107658
116Joint contractures involving the joints of the feet (HP:0100492)1.75663058
117Flexion contracture of toe (HP:0005830)1.75663058
118Deviation of the thumb (HP:0009603)1.75585045
119Coxa vara (HP:0002812)1.75225136
120Bronchomalacia (HP:0002780)1.75138907
121Wormian bones (HP:0002645)1.75100308
122Shawl scrotum (HP:0000049)1.74994734
123Abnormality of the distal phalanx of the thumb (HP:0009617)1.74496292
124Flat acetabular roof (HP:0003180)1.74060788
125Septate vagina (HP:0001153)1.72357738
126Easy fatigability (HP:0003388)1.72272517
127Abnormality of the lacrimal duct (HP:0011481)1.71159985
128Ureteral stenosis (HP:0000071)1.71033929
129Esophageal varix (HP:0002040)1.69530914
130Malignant gastrointestinal tract tumors (HP:0006749)1.68858115
131Gastrointestinal carcinoma (HP:0002672)1.68858115
132Distal lower limb amyotrophy (HP:0008944)1.68548921
133Abnormality of the acetabulum (HP:0003170)1.67304240
134Mitral regurgitation (HP:0001653)1.67225749
135Bicornuate uterus (HP:0000813)1.67167670
136Vascular tortuosity (HP:0004948)1.67058345
137Abnormality of the dental root (HP:0006486)1.66643874
138Taurodontia (HP:0000679)1.66643874
139Abnormality of permanent molar morphology (HP:0011071)1.66643874
140Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.66367602
141Vertebral hypoplasia (HP:0008417)1.66367602
142Biliary tract neoplasm (HP:0100574)1.64954312
143Abnormality of the calcaneus (HP:0008364)1.64363351
144Dilatation of the ascending aorta (HP:0005111)1.61435590
145Congenital hip dislocation (HP:0001374)1.61019366
146Achilles tendon contracture (HP:0001771)1.60998100
147Genu recurvatum (HP:0002816)1.60701787
148Renal duplication (HP:0000075)1.60085762
149Increased variability in muscle fiber diameter (HP:0003557)1.59827020
150Blue sclerae (HP:0000592)1.59517350
151Subacute progressive viral hepatitis (HP:0006572)1.59183916
152Arnold-Chiari malformation (HP:0002308)1.58512239
153Abnormality of molar (HP:0011077)1.57026297
154Abnormality of molar morphology (HP:0011070)1.57026297
155Vertebral arch anomaly (HP:0008438)1.56493810
156Metaphyseal cupping (HP:0003021)1.55643277
157Hypercholesterolemia (HP:0003124)1.53811467
158Ridged nail (HP:0001807)1.53683633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.71304905
2MST1R5.57449591
3TIE13.84661878
4TTN3.76262437
5SCYL23.56598288
6CDK122.95938925
7TRIB32.68633405
8PKN22.58934887
9LATS12.51459686
10SMG12.32124239
11EEF2K2.21115950
12IRAK32.14332636
13PAK42.09452169
14RPS6KB22.08008872
15RIPK12.07787054
16PDGFRA1.88889496
17EPHB21.77898005
18PTK61.69574892
19FER1.66056627
20NTRK11.61236637
21PTK21.57785127
22KDR1.56520813
23DDR21.50495527
24MAP3K101.47385042
25LATS21.44612185
26NEK11.41184460
27BMX1.39233615
28MET1.39202368
29MTOR1.35199317
30LRRK21.34969040
31NEK21.34726385
32TGFBR11.28454320
33STK101.26890892
34TGFBR21.24952289
35ICK1.23408484
36PAK21.22897447
37MAPKAPK31.14272895
38NME11.13691961
39DMPK1.13550156
40STK38L1.07895358
41SIK11.01263412
42MARK21.00039825
43MAP3K60.98187010
44EPHB10.98175625
45LMTK20.92185941
46MAP3K80.92152065
47TTK0.90546308
48FGFR10.89917289
49RPS6KA20.88030141
50STK30.87050577
51CDK60.86119893
52BRD40.85836794
53MAP3K30.85261513
54PRKD20.82617119
55MST40.82606271
56ERN10.80355290
57AKT20.75611756
58NME20.75372070
59MAP3K90.75182165
60TYRO30.74467304
61PDGFRB0.74349051
62PRKCI0.74027627
63ALK0.73524842
64CAMK1D0.70872876
65FLT30.70007700
66CDK70.69729290
67TRPM70.69455285
68MYLK0.67370802
69MAP2K20.65637566
70TSSK60.62266458
71SIK20.61049119
72PAK30.59136089
73PRKG20.58389274
74FGFR40.56576479
75PRPF4B0.56137709
76ILK0.55746316
77MUSK0.55694257
78AURKB0.55238065
79ERBB40.54376664
80FGFR30.53035073
81CDC70.52586347
82PDK40.52273088
83PDK30.52273088
84RPS6KL10.51724726
85TESK10.51723288
86CDK40.50381270
87WNK40.50120754
88MAP2K30.48099436
89PDK20.46735629
90ROCK10.45503487
91PDPK10.45175930
92MAPK110.44650684
93PRKD10.44383940
94WEE10.44180338
95FGFR20.43813320
96MAPK150.42966521
97CDK80.42886322
98PRKD30.42688554
99PASK0.42459077
100RET0.41967435
101GSK3A0.41327583
102DYRK1B0.41112775
103MAP3K70.41032554
104STK40.40410920
105AKT30.40394064
106CHUK0.40098609
107PTK2B0.39797483
108IRAK20.39547815
109HIPK20.39443004
110CHEK10.39067497
111ROCK20.38822392
112ERBB20.38441631
113PAK10.38027396
114PLK10.37155228
115MAP2K60.36438425
116CAMK1G0.35580950
117RPS6KA60.35535246
118MAP2K10.35405356
119CDC42BPA0.34451104
120CDK90.33091319
121PRKAA10.32543405
122NEK60.31718620
123PRKAA20.30948997
124ARAF0.30266936
125MAP3K20.30240126
126MAPK80.29979755
127STK380.29500310
128MAP3K130.29234959
129CSNK1E0.28266815
130CSNK1D0.27893484
131RPS6KA10.27666966
132MAPKAPK20.27528813
133SRC0.27521924
134RPS6KC10.27426693
135CAMK2G0.26630037
136MAP3K10.25297491
137CAMK2B0.24829856
138TAOK10.24442025
139MAPK100.21907334
140MAPK10.20882832

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045123.84517732
2Adherens junction_Homo sapiens_hsa045202.87528043
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.65998978
4* Small cell lung cancer_Homo sapiens_hsa052222.57375409
5Hippo signaling pathway_Homo sapiens_hsa043902.56580770
6* Focal adhesion_Homo sapiens_hsa045102.53459424
7Tight junction_Homo sapiens_hsa045302.41196827
8Basal cell carcinoma_Homo sapiens_hsa052172.35965235
9Proteoglycans in cancer_Homo sapiens_hsa052052.24349294
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.13790612
11Bladder cancer_Homo sapiens_hsa052192.09613882
12Dilated cardiomyopathy_Homo sapiens_hsa054142.09347746
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.05211142
14Notch signaling pathway_Homo sapiens_hsa043301.91844433
15Other glycan degradation_Homo sapiens_hsa005111.91471339
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.90971336
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.88543826
18MicroRNAs in cancer_Homo sapiens_hsa052061.85124162
19Hedgehog signaling pathway_Homo sapiens_hsa043401.73988054
20* Amoebiasis_Homo sapiens_hsa051461.72638305
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.61290864
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.61092238
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61087277
24TGF-beta signaling pathway_Homo sapiens_hsa043501.56340120
25Viral myocarditis_Homo sapiens_hsa054161.52114583
26Fructose and mannose metabolism_Homo sapiens_hsa000511.42010994
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37927727
28Thyroid cancer_Homo sapiens_hsa052161.37588283
29Regulation of actin cytoskeleton_Homo sapiens_hsa048101.37309834
30Chronic myeloid leukemia_Homo sapiens_hsa052201.36712627
31Galactose metabolism_Homo sapiens_hsa000521.33537711
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33096679
33* Pathways in cancer_Homo sapiens_hsa052001.32397992
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28940862
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.28122113
36Protein digestion and absorption_Homo sapiens_hsa049741.28068417
37RNA transport_Homo sapiens_hsa030131.27960117
38p53 signaling pathway_Homo sapiens_hsa041151.27005006
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26940800
40Arginine biosynthesis_Homo sapiens_hsa002201.25123027
41Lysine degradation_Homo sapiens_hsa003101.17817338
42Pentose phosphate pathway_Homo sapiens_hsa000301.17654835
43* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.17256827
44Vitamin B6 metabolism_Homo sapiens_hsa007501.14858347
45mTOR signaling pathway_Homo sapiens_hsa041501.13636349
46Endometrial cancer_Homo sapiens_hsa052131.13054893
47Cell cycle_Homo sapiens_hsa041101.12854953
48Renal cell carcinoma_Homo sapiens_hsa052111.11548060
49Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10821177
50Rap1 signaling pathway_Homo sapiens_hsa040151.09491764
51HIF-1 signaling pathway_Homo sapiens_hsa040661.08825196
52Dorso-ventral axis formation_Homo sapiens_hsa043201.07536992
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07017595
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05810094
55Bile secretion_Homo sapiens_hsa049761.05197492
56HTLV-I infection_Homo sapiens_hsa051661.03357588
57N-Glycan biosynthesis_Homo sapiens_hsa005101.03069005
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01025624
59Wnt signaling pathway_Homo sapiens_hsa043100.99561849
60One carbon pool by folate_Homo sapiens_hsa006700.97870232
61Viral carcinogenesis_Homo sapiens_hsa052030.97856300
62Melanoma_Homo sapiens_hsa052180.95355494
63Colorectal cancer_Homo sapiens_hsa052100.94801149
64ABC transporters_Homo sapiens_hsa020100.93210520
65Phenylalanine metabolism_Homo sapiens_hsa003600.90671467
66Choline metabolism in cancer_Homo sapiens_hsa052310.89365056
67GnRH signaling pathway_Homo sapiens_hsa049120.88379973
68Prion diseases_Homo sapiens_hsa050200.88269751
69* Toxoplasmosis_Homo sapiens_hsa051450.87719425
70Prostate cancer_Homo sapiens_hsa052150.84815235
71Pancreatic cancer_Homo sapiens_hsa052120.82833061
72Biosynthesis of amino acids_Homo sapiens_hsa012300.82564828
73VEGF signaling pathway_Homo sapiens_hsa043700.81794437
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.81307887
75Inositol phosphate metabolism_Homo sapiens_hsa005620.80230687
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79234054
77Axon guidance_Homo sapiens_hsa043600.78224118
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77369974
79Insulin resistance_Homo sapiens_hsa049310.77014317
80mRNA surveillance pathway_Homo sapiens_hsa030150.76850817
81Melanogenesis_Homo sapiens_hsa049160.75274769
82Carbon metabolism_Homo sapiens_hsa012000.73957989
83AMPK signaling pathway_Homo sapiens_hsa041520.72323145
84Spliceosome_Homo sapiens_hsa030400.71929473
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70408550
86Sulfur relay system_Homo sapiens_hsa041220.69559360
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67637044
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67191148
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64263593
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63583863
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63572459
92Estrogen signaling pathway_Homo sapiens_hsa049150.63372264
93Ovarian steroidogenesis_Homo sapiens_hsa049130.61823024
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60376762
95Glioma_Homo sapiens_hsa052140.60226526
96Platelet activation_Homo sapiens_hsa046110.60098565
97Mismatch repair_Homo sapiens_hsa034300.58832968
98Vibrio cholerae infection_Homo sapiens_hsa051100.57945185
99Non-small cell lung cancer_Homo sapiens_hsa052230.57451835
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56880691
101Insulin signaling pathway_Homo sapiens_hsa049100.56594995
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56363878
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55094350
104Acute myeloid leukemia_Homo sapiens_hsa052210.54696743
105Hepatitis C_Homo sapiens_hsa051600.54545069
106FoxO signaling pathway_Homo sapiens_hsa040680.54339450
107Steroid biosynthesis_Homo sapiens_hsa001000.54026548
108Apoptosis_Homo sapiens_hsa042100.53971475
109Complement and coagulation cascades_Homo sapiens_hsa046100.53304503
110Shigellosis_Homo sapiens_hsa051310.52877164
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.52156346
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51665733
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51600577
114Vitamin digestion and absorption_Homo sapiens_hsa049770.51251832
115Gap junction_Homo sapiens_hsa045400.51058542
116Salmonella infection_Homo sapiens_hsa051320.50552774
117DNA replication_Homo sapiens_hsa030300.47893427
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47295628
119Glucagon signaling pathway_Homo sapiens_hsa049220.47265899
120Systemic lupus erythematosus_Homo sapiens_hsa053220.46651054
121Fatty acid biosynthesis_Homo sapiens_hsa000610.45493458
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.43893548
123Renin-angiotensin system_Homo sapiens_hsa046140.41754079
124Endocytosis_Homo sapiens_hsa041440.41459159
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36635854
126Hepatitis B_Homo sapiens_hsa051610.35791589
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35403732
128Oocyte meiosis_Homo sapiens_hsa041140.33576975
129Thyroid hormone synthesis_Homo sapiens_hsa049180.33510368
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.33244888
131ErbB signaling pathway_Homo sapiens_hsa040120.32650611
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32114000
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30556149

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »