LAMB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polarized epithelial cell differentiation (GO:0030859)8.61038194
2establishment of apical/basal cell polarity (GO:0035089)7.11022271
3retina vasculature morphogenesis in camera-type eye (GO:0061299)6.81658044
4basement membrane organization (GO:0071711)6.78123554
5establishment of monopolar cell polarity (GO:0061162)6.12255160
6establishment or maintenance of monopolar cell polarity (GO:0061339)6.12255160
7endocardial cushion development (GO:0003197)5.99168962
8regulation of cardioblast differentiation (GO:0051890)5.86524986
9embryonic foregut morphogenesis (GO:0048617)5.73851030
10hemidesmosome assembly (GO:0031581)5.33776817
11branching involved in salivary gland morphogenesis (GO:0060445)5.29675936
12atrioventricular valve morphogenesis (GO:0003181)5.28122621
13peptidyl-proline hydroxylation (GO:0019511)4.86964815
14regulation of transforming growth factor beta2 production (GO:0032909)4.79990934
15collagen fibril organization (GO:0030199)4.47346227
16protein hydroxylation (GO:0018126)4.35575252
17establishment of epithelial cell polarity (GO:0090162)4.25658372
18protein heterotrimerization (GO:0070208)4.16555414
19endoderm formation (GO:0001706)4.14505697
20glomerular basement membrane development (GO:0032836)4.03059367
21establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)4.02929514
22chondrocyte proliferation (GO:0035988)3.91960160
23morphogenesis of an epithelial sheet (GO:0002011)3.88607769
24cell migration involved in heart development (GO:0060973)3.85435638
25paraxial mesoderm development (GO:0048339)3.84339421
26COPI coating of Golgi vesicle (GO:0048205)3.79861354
27Golgi transport vesicle coating (GO:0048200)3.79861354
28hippo signaling (GO:0035329)3.78278671
29endothelial cell morphogenesis (GO:0001886)3.76058534
30negative regulation of chondrocyte differentiation (GO:0032331)3.75046742
31atrial septum morphogenesis (GO:0060413)3.71309726
32response to follicle-stimulating hormone (GO:0032354)3.68544793
33regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.66483143
34negative regulation of cell fate specification (GO:0009996)3.60471219
35* substrate adhesion-dependent cell spreading (GO:0034446)3.60177885
36gastrulation with mouth forming second (GO:0001702)3.58737961
374-hydroxyproline metabolic process (GO:0019471)3.55211203
38cardiac right ventricle morphogenesis (GO:0003215)3.54242639
39epithelial cell-cell adhesion (GO:0090136)3.52001621
40cell-substrate junction assembly (GO:0007044)3.49148956
41regulation of hippo signaling (GO:0035330)3.47723314
42regulation of gene silencing by RNA (GO:0060966)3.44079882
43regulation of posttranscriptional gene silencing (GO:0060147)3.44079882
44regulation of gene silencing by miRNA (GO:0060964)3.44079882
45bone trabecula formation (GO:0060346)3.41496738
46cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.39234925
47* endodermal cell differentiation (GO:0035987)3.38894401
48epithelial tube branching involved in lung morphogenesis (GO:0060441)3.38006245
49blood vessel maturation (GO:0001955)3.37819893
50organ formation (GO:0048645)3.35867142
51protein retention in ER lumen (GO:0006621)3.35259243
52epithelial cell fate commitment (GO:0072148)3.27320657
53substrate-dependent cell migration (GO:0006929)3.26088840
54extracellular fibril organization (GO:0043206)3.25678540
55renal system development (GO:0072001)3.24024940
56endoderm development (GO:0007492)3.24015803
57mesenchymal-epithelial cell signaling (GO:0060638)3.23995432
58collagen metabolic process (GO:0032963)3.18512499
59regulation of SMAD protein import into nucleus (GO:0060390)3.18103600
60planar cell polarity pathway involved in neural tube closure (GO:0090179)3.17530347
61lymphangiogenesis (GO:0001946)3.17019989
62cardiac myofibril assembly (GO:0055003)3.15714018
63mesenchyme development (GO:0060485)3.13828204
64lung-associated mesenchyme development (GO:0060484)3.11848682
65wound healing, spreading of epidermal cells (GO:0035313)3.10313309
66* extracellular matrix disassembly (GO:0022617)3.09961838
67regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.07545130
68desmosome organization (GO:0002934)3.04399487
69apoptotic cell clearance (GO:0043277)3.02384756
70cardiac muscle hypertrophy in response to stress (GO:0014898)3.02237270
71muscle hypertrophy in response to stress (GO:0003299)3.02237270
72cardiac muscle adaptation (GO:0014887)3.02237270
73vascular endothelial growth factor signaling pathway (GO:0038084)3.01093499
74negative regulation of fatty acid transport (GO:2000192)3.01023249
75multicellular organismal macromolecule metabolic process (GO:0044259)3.00997913
76mesodermal cell differentiation (GO:0048333)3.00120783
77protein localization to cell surface (GO:0034394)3.00118428
78collagen catabolic process (GO:0030574)2.99357422
79regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.99173950
80positive regulation of osteoblast proliferation (GO:0033690)2.99111648
81cell adhesion mediated by integrin (GO:0033627)2.98780011
82regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.98023652
83insulin-like growth factor receptor signaling pathway (GO:0048009)2.97976026
84establishment or maintenance of bipolar cell polarity (GO:0061245)2.94956511
85establishment or maintenance of apical/basal cell polarity (GO:0035088)2.94956511
86positive regulation of endothelial cell apoptotic process (GO:2000353)2.94300141
87regulation of cell fate specification (GO:0042659)2.91640405
88wound healing, spreading of cells (GO:0044319)2.91639461
89plasma membrane repair (GO:0001778)2.90188126
90kidney mesenchyme development (GO:0072074)2.89094921
91positive regulation of SMAD protein import into nucleus (GO:0060391)2.87507863
92multicellular organismal metabolic process (GO:0044236)2.84905076
93positive regulation of blood vessel endothelial cell migration (GO:0043536)2.83874216
94regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.83211266
95metanephric mesenchyme development (GO:0072075)2.83200641
96venous blood vessel morphogenesis (GO:0048845)2.82619887
97* extracellular matrix organization (GO:0030198)2.82043095
98* extracellular structure organization (GO:0043062)2.80883634
99skin morphogenesis (GO:0043589)2.80288693
100renal filtration (GO:0097205)2.79898513
101focal adhesion assembly (GO:0048041)2.79404737
102cell-substrate adherens junction assembly (GO:0007045)2.79404737
103regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.78945586
104positive regulation of stem cell differentiation (GO:2000738)2.76854923
105adherens junction assembly (GO:0034333)2.76786763
106cell migration involved in sprouting angiogenesis (GO:0002042)2.76149857
107axon extension involved in axon guidance (GO:0048846)2.75832753
108neuron projection extension involved in neuron projection guidance (GO:1902284)2.75832753
109semaphorin-plexin signaling pathway (GO:0071526)2.75650231
110multicellular organismal catabolic process (GO:0044243)2.74699742
111regulation of plasminogen activation (GO:0010755)2.73690645
112seminiferous tubule development (GO:0072520)2.73590437
113negative regulation of cartilage development (GO:0061037)2.73490763
114fibril organization (GO:0097435)2.72344877
115SMAD protein signal transduction (GO:0060395)2.70656999
116positive regulation of epithelial to mesenchymal transition (GO:0010718)2.67124627
117vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.66797741
118negative regulation of embryonic development (GO:0045992)2.66722858
119formation of primary germ layer (GO:0001704)2.66598344
120ventricular septum development (GO:0003281)2.64605937
121cell proliferation involved in metanephros development (GO:0072203)2.63686325
122COPII vesicle coating (GO:0048208)2.63633978
123regulation of chondrocyte differentiation (GO:0032330)2.63525494
124organ induction (GO:0001759)2.63472122
125cytoskeletal anchoring at plasma membrane (GO:0007016)2.63146248
126chondrocyte development (GO:0002063)2.61652301
127cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.61639980
128trabecula formation (GO:0060343)2.61046095
129sequestering of extracellular ligand from receptor (GO:0035581)2.60838330
130regulation of tight junction assembly (GO:2000810)2.60204640
131Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.60048735
132lung vasculature development (GO:0060426)2.60019502
133glomerular filtration (GO:0003094)2.59959455
134type B pancreatic cell proliferation (GO:0044342)2.59166324
135regulation of gastrulation (GO:0010470)2.59081252
136cardiac septum morphogenesis (GO:0060411)2.58837536
137extracellular matrix assembly (GO:0085029)2.58696152
138muscle cell migration (GO:0014812)2.58617341
139positive regulation of cardiac muscle cell proliferation (GO:0060045)2.58439002
140positive regulation of cartilage development (GO:0061036)2.58078911
141regulation of cartilage development (GO:0061035)2.56625464
142endothelial cell proliferation (GO:0001935)2.56612684
143maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55820754
144dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.54826232
145regulation of cardiac muscle cell contraction (GO:0086004)2.54654222
146cardiac muscle hypertrophy (GO:0003300)2.54267842
147glomerular visceral epithelial cell development (GO:0072015)2.53992756
148heart valve morphogenesis (GO:0003179)2.53886646
149smooth muscle tissue development (GO:0048745)2.52146476
150regulation of establishment of planar polarity (GO:0090175)2.50674295
151signal transduction involved in regulation of gene expression (GO:0023019)2.48972261
152regulation of extracellular matrix disassembly (GO:0010715)2.47005270
153cell-matrix adhesion (GO:0007160)2.46993096
154notochord development (GO:0030903)2.46943704
155cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.46126282
156cellular response to vitamin (GO:0071295)2.45893424
157positive regulation of endothelial cell migration (GO:0010595)2.45062541
158* cell-substrate adhesion (GO:0031589)2.43340801

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.52061175
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.15685217
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.53264709
4ZNF263_19887448_ChIP-Seq_K562_Human3.51388109
5SALL4_18804426_ChIP-ChIP_XEN_Mouse3.38668955
6CLOCK_20551151_ChIP-Seq_293T_Human3.33031339
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.31318349
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.94707590
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.86350518
10AR_21909140_ChIP-Seq_LNCAP_Human2.68133906
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.48072351
12ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.47377449
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.33487093
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29140899
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.25680518
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.25398840
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.25090916
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.15520333
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.08314509
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07238765
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.96992293
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.94771681
23SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.94205036
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.89859126
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.88987128
26* GATA2_21666600_ChIP-Seq_HMVEC_Human1.88853544
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.82103638
28* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.80258831
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.79319263
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.79282197
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.78771876
32BRD4_25478319_ChIP-Seq_HGPS_Human1.76511779
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.74877879
34* CJUN_26792858_Chip-Seq_BT549_Human1.71482194
35* ELK3_25401928_ChIP-Seq_HUVEC_Human1.69821361
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.69172381
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.67701769
38* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66168166
39* UBF1/2_26484160_Chip-Seq_HMECs_Human1.64822278
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63790271
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.61445135
42ISL1_27105846_Chip-Seq_CPCs_Mouse1.60582261
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59014938
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58727297
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.58061757
46ATF3_27146783_Chip-Seq_COLON_Human1.55778428
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55612652
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55571386
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55276604
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.54387004
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53682947
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52601079
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51830514
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51465326
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51465326
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51137995
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50793062
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.50213494
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49361202
60TBX20_22328084_ChIP-Seq_HEART_Mouse1.48192366
61TBX20_22080862_ChIP-Seq_HEART_Mouse1.48192366
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43577272
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.39758403
64SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.38600924
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37604468
66E2F7_22180533_ChIP-Seq_HELA_Human1.37092895
67TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36974633
68MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.36835334
69EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.36086341
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35086147
71RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35086147
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34730774
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31529770
74TP53_18474530_ChIP-ChIP_U2OS_Human1.31295687
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.30614294
76TP53_22127205_ChIP-Seq_IMR90_Human1.30038542
77RACK7_27058665_Chip-Seq_MCF-7_Human1.29604881
78NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28541680
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.28528942
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24608675
81TP53_16413492_ChIP-PET_HCT116_Human1.24399974
82SMC1_22415368_ChIP-Seq_MEFs_Mouse1.23813873
83CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22184314
84SOX17_20123909_ChIP-Seq_XEN_Mouse1.21878101
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20609370
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20391476
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20391476
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20391476
89EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19735902
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16208494
91FOXA2_19822575_ChIP-Seq_HepG2_Human1.13315936
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12776770
93SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12493218
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12488066
95SOX2_20726797_ChIP-Seq_SW620_Human1.12248213
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12104675
97NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10210281
98CDX2_20551321_ChIP-Seq_CACO-2_Human1.09287001
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08778032
100* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.08221646
101KDM2B_26808549_Chip-Seq_K562_Human1.07920296
102NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07171120
103PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06447225
104SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05355666
105PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05203245
106SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05106631
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03170834
108SA1_22415368_ChIP-Seq_MEFs_Mouse1.03151564
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00039252
110TCF4_18268006_ChIP-ChIP_LS174T_Human0.99770547
111LXR_22292898_ChIP-Seq_THP-1_Human0.98097823
112SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97652419
113SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97205774
114* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97081267
115JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97051848
116TP53_23651856_ChIP-Seq_MEFs_Mouse0.96668614
117KDM2B_26808549_Chip-Seq_JURKAT_Human0.96473505
118ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95840402
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95486776
120ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94973991
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93328866
122KDM2B_26808549_Chip-Seq_DND41_Human0.92658998
123SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92009851
124GATA4_21415370_ChIP-Seq_HL-1_Mouse0.91791065
125TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88582195
126CHD1_26751641_Chip-Seq_LNCaP_Human0.88421339
127TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.87465445
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87261552
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87261552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane6.60503563
2MP0008438_abnormal_cutaneous_collagen5.86925869
3MP0005623_abnormal_meninges_morphology4.97003258
4MP0003705_abnormal_hypodermis_morpholog3.53419322
5MP0005275_abnormal_skin_tensile3.47305073
6MP0009384_cardiac_valve_regurgitation3.41149591
7MP0005503_abnormal_tendon_morphology2.80210752
8MP0004858_abnormal_nervous_system2.47744782
9MP0003279_aneurysm2.26288329
10MP0003941_abnormal_skin_development2.13708335
11MP0001958_emphysema2.12409247
12MP0003567_abnormal_fetal_cardiomyocyte1.86223429
13MP0003566_abnormal_cell_adhesion1.80141217
14MP0006054_spinal_hemorrhage1.79768269
15MP0001879_abnormal_lymphatic_vessel1.78432300
16MP0003950_abnormal_plasma_membrane1.75004283
17MP0000534_abnormal_ureter_morphology1.72677095
18MP0001915_intracranial_hemorrhage1.67352138
19MP0003119_abnormal_digestive_system1.66334115
20MP0003115_abnormal_respiratory_system1.65568976
21MP0003942_abnormal_urinary_system1.65407138
22MP0003828_pulmonary_edema1.62449169
23MP0010352_gastrointestinal_tract_polyps1.59068835
24MP0006138_congestive_heart_failure1.58888019
25MP0000751_myopathy1.56136179
26MP0000537_abnormal_urethra_morphology1.45815948
27MP0005508_abnormal_skeleton_morphology1.45753991
28MP0004084_abnormal_cardiac_muscle1.44928434
29MP0000733_abnormal_muscle_development1.44386253
30MP0003385_abnormal_body_wall1.43364632
31MP0009780_abnormal_chondrocyte_physiolo1.42230205
32MP0010030_abnormal_orbit_morphology1.42214295
33MP0003283_abnormal_digestive_organ1.36680674
34MP0003091_abnormal_cell_migration1.36329892
35MP0002697_abnormal_eye_size1.36134845
36MP0000767_abnormal_smooth_muscle1.34821019
37MP0002877_abnormal_melanocyte_morpholog1.33597491
38MP0005409_darkened_coat_color1.33122967
39MP0009053_abnormal_anal_canal1.31784542
40MP0004197_abnormal_fetal_growth/weight/1.29363737
41MP0005076_abnormal_cell_differentiation1.25984618
42MP0005023_abnormal_wound_healing1.24842090
43MP0002060_abnormal_skin_morphology1.22933488
44MP0010368_abnormal_lymphatic_system1.20626153
45* MP0002084_abnormal_developmental_patter1.17769643
46MP0009250_abnormal_appendicular_skeleto1.14899545
47MP0002896_abnormal_bone_mineralization1.14110001
48MP0000428_abnormal_craniofacial_morphol1.13842461
49MP0000750_abnormal_muscle_regeneration1.12031878
50MP0003984_embryonic_growth_retardation1.11928225
51MP0002088_abnormal_embryonic_growth/wei1.10968679
52MP0001661_extended_life_span1.10545235
53MP0004087_abnormal_muscle_fiber1.07818656
54MP0003123_paternal_imprinting1.07671734
55MP0001672_abnormal_embryogenesis/_devel1.07543425
56MP0005380_embryogenesis_phenotype1.07543425
57MP0005595_abnormal_vascular_smooth1.06625287
58* MP0002086_abnormal_extraembryonic_tissu1.05528258
59MP0005197_abnormal_uvea_morphology1.05275380
60MP0000462_abnormal_digestive_system1.04671085
61MP0010630_abnormal_cardiac_muscle1.04651595
62MP0002108_abnormal_muscle_morphology1.03499516
63MP0002932_abnormal_joint_morphology1.03161624
64MP0009672_abnormal_birth_weight1.02932788
65MP0001542_abnormal_bone_strength1.01434515
66MP0003935_abnormal_craniofacial_develop0.98669769
67MP0001243_abnormal_dermal_layer0.97721076
68MP0002925_abnormal_cardiovascular_devel0.97480831
69MP0002295_abnormal_pulmonary_circulatio0.96736362
70MP0010234_abnormal_vibrissa_follicle0.94497458
71MP0001697_abnormal_embryo_size0.94306819
72MP0002269_muscular_atrophy0.94080622
73MP0002085_abnormal_embryonic_tissue0.93965614
74MP0003937_abnormal_limbs/digits/tail_de0.93379021
75MP0001614_abnormal_blood_vessel0.92617657
76MP0001348_abnormal_lacrimal_gland0.91421139
77MP0005257_abnormal_intraocular_pressure0.91189398
78MP0002111_abnormal_tail_morphology0.90162925
79MP0002282_abnormal_trachea_morphology0.89954513
80MP0002128_abnormal_blood_circulation0.89244811
81MP0000516_abnormal_urinary_system0.88143583
82MP0005367_renal/urinary_system_phenotyp0.88143583
83MP0004233_abnormal_muscle_weight0.88018047
84MP0001730_embryonic_growth_arrest0.87378219
85MP0002127_abnormal_cardiovascular_syste0.87078271
86MP0001849_ear_inflammation0.85306455
87MP0003221_abnormal_cardiomyocyte_apopto0.84781496
88MP0000432_abnormal_head_morphology0.84655215
89* MP0004957_abnormal_blastocyst_morpholog0.84644815
90MP0008004_abnormal_stomach_pH0.84552203
91MP0003122_maternal_imprinting0.83823476
92MP0000467_abnormal_esophagus_morphology0.83095623
93MP0003755_abnormal_palate_morphology0.83058926
94MP0002089_abnormal_postnatal_growth/wei0.81568725
95MP0005385_cardiovascular_system_phenoty0.81224619
96MP0001544_abnormal_cardiovascular_syste0.81224619
97MP0005171_absent_coat_pigmentation0.80080442
98MP0002933_joint_inflammation0.77872380
99MP0005084_abnormal_gallbladder_morpholo0.77648514
100MP0000003_abnormal_adipose_tissue0.77114154
101MP0001175_abnormal_lung_morphology0.77071846
102MP0000266_abnormal_heart_morphology0.76930295
103MP0009703_decreased_birth_body0.76218952
104MP0000759_abnormal_skeletal_muscle0.75551170
105MP0000163_abnormal_cartilage_morphology0.74364204
106MP0005330_cardiomyopathy0.74198963
107MP0001299_abnormal_eye_distance/0.73516536
108MP0003045_fibrosis0.73421539
109MP0005193_abnormal_anterior_eye0.72645917
110MP0002168_other_aberrant_phenotype0.71922384
111MP0005360_urolithiasis0.71918343
112MP0003300_gastrointestinal_ulcer0.71800692
113MP0000049_abnormal_middle_ear0.70929477
114MP0002116_abnormal_craniofacial_bone0.70865461
115MP0008775_abnormal_heart_ventricle0.70535473
116MP0000013_abnormal_adipose_tissue0.69874610
117MP0002972_abnormal_cardiac_muscle0.69718562
118MP0004185_abnormal_adipocyte_glucose0.69118628
119MP0002092_abnormal_eye_morphology0.68935103
120MP0000762_abnormal_tongue_morphology0.67949453
121MP0002106_abnormal_muscle_physiology0.67790674
122MP0002115_abnormal_skeleton_extremities0.67587763
123MP0002113_abnormal_skeleton_development0.67431615
124MP0004036_abnormal_muscle_relaxation0.65056537
125MP0002114_abnormal_axial_skeleton0.64214100
126MP0002233_abnormal_nose_morphology0.63164236
127MP0005390_skeleton_phenotype0.60772941
128MP0005164_abnormal_response_to0.59909792
129MP0000566_synostosis0.59855738
130MP0005369_muscle_phenotype0.59167588
131MP0009840_abnormal_foam_cell0.57169191

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.39285713
2Premature rupture of membranes (HP:0001788)6.12667913
3Cerebral aneurysm (HP:0004944)5.21776762
4Shallow orbits (HP:0000586)5.10613129
5Ankle contracture (HP:0006466)4.63089558
6Vascular tortuosity (HP:0004948)4.35886599
7Arterial tortuosity (HP:0005116)4.20451566
8Cerebellar dysplasia (HP:0007033)4.07005389
9Aortic dissection (HP:0002647)3.52655267
10Atrophic scars (HP:0001075)3.48487832
11Retinal atrophy (HP:0001105)3.47346739
12Broad metatarsal (HP:0001783)3.37841752
13Wrist flexion contracture (HP:0001239)3.28225785
14Cervical subluxation (HP:0003308)3.20884899
15Bladder diverticulum (HP:0000015)3.14152262
16Soft skin (HP:0000977)3.13682560
17Abnormality of dentin (HP:0010299)3.04480926
18Vertebral compression fractures (HP:0002953)2.94086560
19Fragile skin (HP:0001030)2.93821796
20Type 1 muscle fiber predominance (HP:0003803)2.89790321
21Wormian bones (HP:0002645)2.88483677
22Spinal rigidity (HP:0003306)2.77744013
23Increased connective tissue (HP:0009025)2.77091969
24Mitral valve prolapse (HP:0001634)2.71838425
25Blue sclerae (HP:0000592)2.67272551
26Dilatation of the ascending aorta (HP:0005111)2.61971353
27Knee flexion contracture (HP:0006380)2.59805666
28Aortic aneurysm (HP:0004942)2.58008286
29Follicular hyperkeratosis (HP:0007502)2.55144252
30Aneurysm (HP:0002617)2.53892687
31Biconcave vertebral bodies (HP:0004586)2.52072723
32Amblyopia (HP:0000646)2.50193089
33Lymphangioma (HP:0100764)2.49247138
34Osteolytic defects of the phalanges of the hand (HP:0009771)2.45588673
35Osteolytic defects of the hand bones (HP:0009699)2.45588673
36Short 4th metacarpal (HP:0010044)2.43792766
37Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.43792766
38Genu recurvatum (HP:0002816)2.39165407
39Short nail (HP:0001799)2.29999734
40Abnormality of proline metabolism (HP:0010907)2.29594543
41Hydroxyprolinuria (HP:0003080)2.29594543
42Thin bony cortex (HP:0002753)2.28008583
43Preaxial foot polydactyly (HP:0001841)2.27343012
44Spondylolisthesis (HP:0003302)2.25544645
45Elbow flexion contracture (HP:0002987)2.24271724
46Disproportionate tall stature (HP:0001519)2.23542329
47Hypoplasia of the iris (HP:0007676)2.21113937
48Hip contracture (HP:0003273)2.20558047
49Deviation of the thumb (HP:0009603)2.18550495
50Peritonitis (HP:0002586)2.18477425
51Increased variability in muscle fiber diameter (HP:0003557)2.14272669
52Mildly elevated creatine phosphokinase (HP:0008180)2.12564059
53Abnormality of carpal bone ossification (HP:0006257)2.10954619
54Hyperextensible skin (HP:0000974)2.10816087
55Ectopia lentis (HP:0001083)2.10297367
56Preauricular pit (HP:0004467)2.09987796
57Periauricular skin pits (HP:0100277)2.09987796
58Joint laxity (HP:0001388)2.09867295
59Pterygium (HP:0001059)2.08690596
60Mitral stenosis (HP:0001718)2.07825640
61Flat acetabular roof (HP:0003180)2.06065376
62Mitral regurgitation (HP:0001653)2.05004434
63Aortic regurgitation (HP:0001659)2.04849103
64Abnormality of the 4th metacarpal (HP:0010012)2.03999470
65Abnormal ventriculo-arterial connection (HP:0011563)2.03245439
66Transposition of the great arteries (HP:0001669)2.03245439
67Abnormal connection of the cardiac segments (HP:0011545)2.03245439
68Neonatal short-limb short stature (HP:0008921)2.02412115
69Missing ribs (HP:0000921)2.02061099
70Coronal craniosynostosis (HP:0004440)2.01344076
71Buphthalmos (HP:0000557)1.99865966
72Bowel diverticulosis (HP:0005222)1.99572522
73Camptodactyly of toe (HP:0001836)1.99346046
74Natal tooth (HP:0000695)1.98704926
75Testicular neoplasm (HP:0010788)1.97906946
76Muscle fiber splitting (HP:0003555)1.97014644
77Coxa vara (HP:0002812)1.96322309
78Broad ribs (HP:0000885)1.95786705
79High pitched voice (HP:0001620)1.95637017
80Inguinal hernia (HP:0000023)1.95453360
81Abnormal ossification of hand bones (HP:0005921)1.95129930
82Limited hip movement (HP:0008800)1.92743184
83Abnormal vertebral ossification (HP:0100569)1.92072494
84Wide anterior fontanel (HP:0000260)1.92064062
85Cardiovascular calcification (HP:0011915)1.89593387
86Renal duplication (HP:0000075)1.89506936
87Bell-shaped thorax (HP:0001591)1.89464984
88Osteoarthritis (HP:0002758)1.87875248
89Proximal placement of thumb (HP:0009623)1.87751980
90Hypoplastic left heart (HP:0004383)1.87566401
91Short hallux (HP:0010109)1.85569323
92Abnormal delivery (HP:0001787)1.85087940
93Abnormality of the acetabulum (HP:0003170)1.84985345
94Broad face (HP:0000283)1.84965095
95Right ventricular cardiomyopathy (HP:0011663)1.84858609
96Femoral bowing (HP:0002980)1.84541951
97Breech presentation (HP:0001623)1.84049128
98Slender build (HP:0001533)1.83979654
99Abnormality of skeletal muscle fiber size (HP:0012084)1.83538134
100Aortic valve stenosis (HP:0001650)1.82983000
101Fused cervical vertebrae (HP:0002949)1.81590695
102Protruding ear (HP:0000411)1.81194561
103Overgrowth (HP:0001548)1.80035848
104Distal upper limb amyotrophy (HP:0007149)1.80008258
105Upper limb amyotrophy (HP:0009129)1.80008258
106Cupped ribs (HP:0000887)1.79597067
107Deviation of the hallux (HP:0010051)1.78758080
108Osteopenia (HP:0000938)1.76330218
109Ulnar bowing (HP:0003031)1.76098455
110Ulnar claw (HP:0001178)1.75866638
111Abnormal umbilical cord blood vessels (HP:0011403)1.74523863
112Single umbilical artery (HP:0001195)1.74523863
113Abnormality of the fetal cardiovascular system (HP:0010948)1.74523863
114Arachnodactyly (HP:0001166)1.74311853
115Short phalanx of the thumb (HP:0009660)1.73839623
116Striae distensae (HP:0001065)1.73612723
117Trismus (HP:0000211)1.73353391
118Premature skin wrinkling (HP:0100678)1.73222619
119Tibial bowing (HP:0002982)1.73184708
120Abnormality of the distal phalanx of the thumb (HP:0009617)1.72643768
121Radial bowing (HP:0002986)1.72572332
122Gonadal dysgenesis (HP:0000133)1.72096925
123Rectal prolapse (HP:0002035)1.72018583
124Abnormality of the 1st metacarpal (HP:0010009)1.71303200
125Advanced eruption of teeth (HP:0006288)1.71103006
126Hallux valgus (HP:0001822)1.71074646
127Turricephaly (HP:0000262)1.70036233
128Aplasia/Hypoplasia of the hallux (HP:0008362)1.69703629
129Delayed cranial suture closure (HP:0000270)1.69447374
130Asymmetry of the thorax (HP:0001555)1.69067429
131Patent foramen ovale (HP:0001655)1.66110583
132Enlarged penis (HP:0000040)1.65844244
133Round ear (HP:0100830)1.65775788
134Joint stiffness (HP:0001387)1.65221130
135Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.64421170
136Hyperacusis (HP:0010780)1.64003942
137Syringomyelia (HP:0003396)1.62920938
138Spinal cord lesions (HP:0100561)1.62920938
139Venous abnormality (HP:0002624)1.62885473
140Bowed forearm bones (HP:0003956)1.62220480
141Bowing of the arm (HP:0006488)1.62220480
142Aplasia involving bones of the extremities (HP:0009825)1.62174026
143Aplasia involving bones of the upper limbs (HP:0009823)1.62174026
144Aplasia of the phalanges of the hand (HP:0009802)1.62174026
145Abnormal hand bone ossification (HP:0010660)1.61605802
146Hypoventilation (HP:0002791)1.61047702
147Neonatal death (HP:0003811)1.60569022

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.85772228
2LATS13.65038255
3PDGFRA3.52481697
4LATS23.41413178
5TTN3.35766899
6PKN23.34542768
7DDR23.17935204
8NTRK13.06967549
9MST1R2.20857612
10RIPK12.06068899
11DMPK1.97650478
12TYRO31.92320328
13PTK61.86728740
14EPHB21.85986218
15EPHA21.77365534
16MOS1.76560569
17CDK121.71039293
18EEF2K1.66764031
19FER1.62157530
20CDK41.58705216
21STK31.57569402
22SIK11.56634853
23PTK21.55846321
24STK38L1.55845172
25MAP3K101.51128988
26AKT31.49699390
27PAK41.44151270
28ERBB41.41799597
29PAK21.41609530
30TIE11.40743244
31LRRK21.40378334
32TGFBR11.38645071
33MTOR1.36931804
34SCYL21.35910712
35FGFR41.33722190
36FGFR11.31427259
37PDGFRB1.22193682
38NEK11.18125605
39MET1.16648328
40PRKD31.15237959
41TTK1.14792028
42BMX1.06223643
43NEK21.03637342
44ILK1.02809633
45SMG11.01950896
46STK101.00153142
47PRKD20.96998851
48PTK2B0.96276651
49PAK30.95789611
50MAP3K80.93863849
51RPS6KA40.87422740
52TGFBR20.84711219
53ROCK10.84336567
54FGFR20.83318685
55RET0.82436504
56FGFR30.81884416
57ICK0.81706668
58LMTK20.81405004
59PDK40.78145378
60PDK30.78145378
61PRKG20.77229422
62CAMK1D0.76411405
63RPS6KB20.76383066
64ERN10.72573309
65MELK0.72257766
66NEK90.72165330
67MAP3K60.71490934
68CDC70.70292763
69CDK60.69137729
70KDR0.67830577
71PRKD10.66678279
72MAP2K10.66635664
73WNK10.64744301
74TRPM70.64465576
75ROCK20.63781251
76IRAK30.62276592
77CDC42BPA0.61722458
78MYLK0.60740445
79LIMK10.59562813
80MAP3K70.59083581
81CDK70.54951356
82CDK80.53877250
83PLK20.53845438
84ABL20.53456944
85ACVR1B0.51856268
86CAMK1G0.50784260
87PLK30.50752239
88TESK10.50008373
89MARK20.49745827
90KSR20.49696195
91CHEK10.49231536
92PAK10.49156428
93MAPKAPK30.46951056
94DAPK30.46897972
95PLK10.46828377
96PIK3CG0.45716542
97CLK10.43550660
98ARAF0.43228661
99INSR0.42438724
100AURKB0.42345862
101MAPK10.41278395
102WNK40.41067721
103FLT30.40752446
104PIK3CA0.40523006
105SRC0.39948944
106AKT20.39589527
107MAPK70.38057454
108PASK0.37218725
109STK380.36795215
110PDPK10.36158626
111CHUK0.34372783
112EPHB10.34331671
113PDK20.34098394
114KSR10.33206545
115ERBB20.33193522
116PIM20.33075897
117ALK0.30820935
118GSK3A0.30340831
119CDK90.30284657
120PRKCI0.30115479
121MAP3K30.28960265
122RPS6KA20.28143273
123FRK0.27859378
124MAP3K20.26743547
125PRKAA20.24330894
126MAP2K30.22997891
127JAK10.18752663
128CAMK2G0.18717012

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045124.88063893
2* Small cell lung cancer_Homo sapiens_hsa052223.55512963
3* Focal adhesion_Homo sapiens_hsa045103.17364224
4* Amoebiasis_Homo sapiens_hsa051462.89290305
5Adherens junction_Homo sapiens_hsa045202.27552163
6Hippo signaling pathway_Homo sapiens_hsa043902.24997666
7Protein digestion and absorption_Homo sapiens_hsa049742.20750184
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.15969048
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.13863671
10Hedgehog signaling pathway_Homo sapiens_hsa043402.13428191
11Proteoglycans in cancer_Homo sapiens_hsa052052.08429899
12Basal cell carcinoma_Homo sapiens_hsa052172.06638734
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.95044309
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.90666981
15Dilated cardiomyopathy_Homo sapiens_hsa054141.89887489
16TGF-beta signaling pathway_Homo sapiens_hsa043501.86246439
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.75187052
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.71074193
19* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.67171652
20MicroRNAs in cancer_Homo sapiens_hsa052061.65761851
21Tight junction_Homo sapiens_hsa045301.64368842
22Bladder cancer_Homo sapiens_hsa052191.62721296
23Other glycan degradation_Homo sapiens_hsa005111.61371668
24Complement and coagulation cascades_Homo sapiens_hsa046101.61059347
25* Toxoplasmosis_Homo sapiens_hsa051451.58254903
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.56419835
27Lysine degradation_Homo sapiens_hsa003101.54546558
28* Pathways in cancer_Homo sapiens_hsa052001.48456293
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48016894
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.45393192
31Viral myocarditis_Homo sapiens_hsa054161.41978780
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.33820708
33Prion diseases_Homo sapiens_hsa050201.32207235
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27207149
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.19453580
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.18362341
37p53 signaling pathway_Homo sapiens_hsa041151.10001126
38Cell cycle_Homo sapiens_hsa041101.09929932
39Chronic myeloid leukemia_Homo sapiens_hsa052201.09860057
40Wnt signaling pathway_Homo sapiens_hsa043101.07904429
41Melanoma_Homo sapiens_hsa052181.07426794
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.06395894
43Renin-angiotensin system_Homo sapiens_hsa046141.04694100
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03009353
45Prostate cancer_Homo sapiens_hsa052150.99317950
46Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99046162
47Rap1 signaling pathway_Homo sapiens_hsa040150.98677848
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96395588
49Notch signaling pathway_Homo sapiens_hsa043300.94213445
50HTLV-I infection_Homo sapiens_hsa051660.91570030
51Axon guidance_Homo sapiens_hsa043600.89657882
52Melanogenesis_Homo sapiens_hsa049160.87765340
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85822365
54Endometrial cancer_Homo sapiens_hsa052130.84524243
55Insulin resistance_Homo sapiens_hsa049310.84302415
56mTOR signaling pathway_Homo sapiens_hsa041500.82052962
57Pancreatic cancer_Homo sapiens_hsa052120.81444174
58HIF-1 signaling pathway_Homo sapiens_hsa040660.81297057
59Colorectal cancer_Homo sapiens_hsa052100.81228179
60AMPK signaling pathway_Homo sapiens_hsa041520.81126705
61Thyroid cancer_Homo sapiens_hsa052160.80833956
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78445229
63Glioma_Homo sapiens_hsa052140.77411762
64Vibrio cholerae infection_Homo sapiens_hsa051100.77410455
65Renal cell carcinoma_Homo sapiens_hsa052110.76967433
66Estrogen signaling pathway_Homo sapiens_hsa049150.76516255
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75691247
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74729034
69RNA transport_Homo sapiens_hsa030130.72441463
70Arginine biosynthesis_Homo sapiens_hsa002200.70283164
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69654839
72Oocyte meiosis_Homo sapiens_hsa041140.68381712
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67950273
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.65305778
75Galactose metabolism_Homo sapiens_hsa000520.65241552
76Viral carcinogenesis_Homo sapiens_hsa052030.65123379
77Pentose phosphate pathway_Homo sapiens_hsa000300.63815408
78Ovarian steroidogenesis_Homo sapiens_hsa049130.63302022
79PPAR signaling pathway_Homo sapiens_hsa033200.63076974
80Platelet activation_Homo sapiens_hsa046110.62793420
81Fatty acid biosynthesis_Homo sapiens_hsa000610.62729637
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61077338
83Fructose and mannose metabolism_Homo sapiens_hsa000510.58271104
84Insulin signaling pathway_Homo sapiens_hsa049100.58140958
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.57790032
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56971769
87Carbon metabolism_Homo sapiens_hsa012000.54846991
88Glucagon signaling pathway_Homo sapiens_hsa049220.53809153
89Gap junction_Homo sapiens_hsa045400.53576090
90Sulfur metabolism_Homo sapiens_hsa009200.52998401
91Biosynthesis of amino acids_Homo sapiens_hsa012300.52383824
92Malaria_Homo sapiens_hsa051440.51454793
93VEGF signaling pathway_Homo sapiens_hsa043700.51034434
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50916236
95Thyroid hormone synthesis_Homo sapiens_hsa049180.50469932
96Shigellosis_Homo sapiens_hsa051310.49663558
97Choline metabolism in cancer_Homo sapiens_hsa052310.49565123
98Vitamin digestion and absorption_Homo sapiens_hsa049770.48726305
99Dorso-ventral axis formation_Homo sapiens_hsa043200.48480216
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48088192
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47206993
102Bile secretion_Homo sapiens_hsa049760.47104745
103Sphingolipid metabolism_Homo sapiens_hsa006000.44130111
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.43619235
105FoxO signaling pathway_Homo sapiens_hsa040680.43200859
106Endocytosis_Homo sapiens_hsa041440.43121360
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41478953
108mRNA surveillance pathway_Homo sapiens_hsa030150.40854914
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.40613410
110Ras signaling pathway_Homo sapiens_hsa040140.40263719
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40152729
112ErbB signaling pathway_Homo sapiens_hsa040120.39986877
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39477435
114Arginine and proline metabolism_Homo sapiens_hsa003300.39162491
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.38328860
116Inositol phosphate metabolism_Homo sapiens_hsa005620.35676918
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35142393
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34336830
119One carbon pool by folate_Homo sapiens_hsa006700.34149116
120GnRH signaling pathway_Homo sapiens_hsa049120.34045882
121N-Glycan biosynthesis_Homo sapiens_hsa005100.33425077
122Hepatitis B_Homo sapiens_hsa051610.33333782
123Non-small cell lung cancer_Homo sapiens_hsa052230.33112709

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