LAMB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)6.05850569
2sarcomere organization (GO:0045214)5.90599926
3plasma membrane repair (GO:0001778)5.65781357
4myofibril assembly (GO:0030239)5.17625209
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.63757985
6muscle filament sliding (GO:0030049)4.57272232
7actin-myosin filament sliding (GO:0033275)4.57272232
8protein heterotrimerization (GO:0070208)4.39485804
9negative regulation of potassium ion transmembrane transport (GO:1901380)4.30350551
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.25378079
11cardiac muscle cell development (GO:0055013)4.23582790
12actomyosin structure organization (GO:0031032)4.21835093
13regulation of skeletal muscle contraction (GO:0014819)4.17035449
14vascular endothelial growth factor signaling pathway (GO:0038084)4.09267562
15heart trabecula formation (GO:0060347)4.08704638
16cardiac cell development (GO:0055006)4.07693161
17actin-mediated cell contraction (GO:0070252)3.96098427
18cardiac muscle contraction (GO:0060048)3.95586482
19regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.92289976
20bundle of His cell to Purkinje myocyte communication (GO:0086069)3.85174875
21epithelial cell-cell adhesion (GO:0090136)3.85088750
22regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.68815880
23regulation of actin filament-based movement (GO:1903115)3.64218493
24planar cell polarity pathway involved in neural tube closure (GO:0090179)3.63335896
25collagen fibril organization (GO:0030199)3.59825383
26ventricular cardiac muscle cell action potential (GO:0086005)3.57247682
27ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.54965152
28carnitine shuttle (GO:0006853)3.54953330
29regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.52926658
30retina vasculature morphogenesis in camera-type eye (GO:0061299)3.51577185
31cardiac muscle tissue morphogenesis (GO:0055008)3.49548406
32basement membrane organization (GO:0071711)3.46350945
33regulation of cardioblast differentiation (GO:0051890)3.41840511
34regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.40962371
35renal filtration (GO:0097205)3.38025246
36trabecula formation (GO:0060343)3.37066533
37regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.36633756
38tricarboxylic acid cycle (GO:0006099)3.34314431
39regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.32590226
40extracellular fibril organization (GO:0043206)3.32191170
41glomerular filtration (GO:0003094)3.31917113
42actin filament-based movement (GO:0030048)3.31067544
43cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.29852977
44extracellular matrix assembly (GO:0085029)3.27297780
45muscle tissue morphogenesis (GO:0060415)3.26299125
46adult heart development (GO:0007512)3.25331594
47regulation of p38MAPK cascade (GO:1900744)3.23355407
48cell adhesion mediated by integrin (GO:0033627)3.21347346
49regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.19228548
50striated muscle hypertrophy (GO:0014897)3.16443842
51cardiac muscle hypertrophy (GO:0003300)3.14134595
52fatty acid transmembrane transport (GO:1902001)3.12672062
53* glomerular basement membrane development (GO:0032836)3.12519865
54negative regulation of chondrocyte differentiation (GO:0032331)3.12080247
55axon extension involved in axon guidance (GO:0048846)3.10941917
56neuron projection extension involved in neuron projection guidance (GO:1902284)3.10941917
57bone trabecula formation (GO:0060346)3.10742027
58cell-substrate junction assembly (GO:0007044)3.10508086
59cell migration involved in sprouting angiogenesis (GO:0002042)3.07912328
60negative regulation of fatty acid transport (GO:2000192)3.07434309
61regulation of relaxation of muscle (GO:1901077)3.07270218
62negative regulation of heart growth (GO:0061117)3.05197566
63negative regulation of cardiac muscle tissue growth (GO:0055022)3.05197566
64atrioventricular valve morphogenesis (GO:0003181)3.02326194
65cardiac muscle cell proliferation (GO:0060038)3.02321836
66kidney mesenchyme development (GO:0072074)3.00500463
67regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.99277901
68striated muscle contraction (GO:0006941)2.98864090
69endodermal cell differentiation (GO:0035987)2.97518631
70COPI coating of Golgi vesicle (GO:0048205)2.96375882
71Golgi transport vesicle coating (GO:0048200)2.96375882
72endocardial cushion development (GO:0003197)2.96167166
73extracellular matrix disassembly (GO:0022617)2.95763993
74metanephric mesenchyme development (GO:0072075)2.94125025
75regulation of tight junction assembly (GO:2000810)2.93769383
76sequestering of extracellular ligand from receptor (GO:0035581)2.93405090
77barbed-end actin filament capping (GO:0051016)2.93161200
78fibroblast migration (GO:0010761)2.91871286
79stress fiber assembly (GO:0043149)2.91211785
80cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.91156260
81collagen metabolic process (GO:0032963)2.90452295
82hemidesmosome assembly (GO:0031581)2.89707984
83regulation of striated muscle contraction (GO:0006942)2.89221383
84cell migration involved in heart development (GO:0060973)2.88370131
85fibril organization (GO:0097435)2.88051222
86cell communication involved in cardiac conduction (GO:0086065)2.87730585
87regulation of the force of heart contraction (GO:0002026)2.87058707
88negative regulation of smooth muscle cell migration (GO:0014912)2.86780704
89apoptotic cell clearance (GO:0043277)2.84964618
90positive regulation of endothelial cell apoptotic process (GO:2000353)2.84507058
91semaphorin-plexin signaling pathway (GO:0071526)2.84463674
92cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.84325217
93branching involved in salivary gland morphogenesis (GO:0060445)2.83316905
94type B pancreatic cell proliferation (GO:0044342)2.82903987
95regulation of plasminogen activation (GO:0010755)2.81763675
96endothelial cell chemotaxis (GO:0035767)2.81158495
97adhesion of symbiont to host (GO:0044406)2.81103513
98multicellular organismal macromolecule metabolic process (GO:0044259)2.80923394
99adherens junction assembly (GO:0034333)2.80814885
100endothelial cell morphogenesis (GO:0001886)2.80533174
101collagen catabolic process (GO:0030574)2.80510533
102cytoskeletal anchoring at plasma membrane (GO:0007016)2.79496304
103regulation of fatty acid oxidation (GO:0046320)2.75058789
104protein retention in ER lumen (GO:0006621)2.74981682
105skin morphogenesis (GO:0043589)2.74589389
106virion attachment to host cell (GO:0019062)2.71760499
107adhesion of symbiont to host cell (GO:0044650)2.71760499
108desmosome organization (GO:0002934)2.71527348
109dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.71432669
110muscle hypertrophy (GO:0014896)2.71359463
111maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.68845031
112positive regulation of blood vessel endothelial cell migration (GO:0043536)2.68375373
113heart morphogenesis (GO:0003007)2.67308185
114regulation of extracellular matrix disassembly (GO:0010715)2.67059842
115regulation of sarcomere organization (GO:0060297)2.67016570
116Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.66916547
117insulin-like growth factor receptor signaling pathway (GO:0048009)2.66891377
118lymph vessel development (GO:0001945)2.65998537
119growth hormone secretion (GO:0030252)2.65923493
120coronary vasculature morphogenesis (GO:0060977)2.64962048
121focal adhesion assembly (GO:0048041)2.64933091
122cell-substrate adherens junction assembly (GO:0007045)2.64933091
123multicellular organismal catabolic process (GO:0044243)2.64395030
124vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.64338965
125multicellular organismal metabolic process (GO:0044236)2.64233912
126carnitine transmembrane transport (GO:1902603)2.63832191
127* extracellular matrix organization (GO:0030198)2.62813021
128regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.61976681
129cell communication by electrical coupling (GO:0010644)2.61973621
130* extracellular structure organization (GO:0043062)2.61782697
131lymphangiogenesis (GO:0001946)2.61385415
132chondrocyte proliferation (GO:0035988)2.60936016
133negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.60890545
134venous blood vessel morphogenesis (GO:0048845)2.60822690
135regulation of cardiac muscle cell contraction (GO:0086004)2.60729886
136substrate-dependent cell migration (GO:0006929)2.59252854
137positive regulation of osteoblast proliferation (GO:0033690)2.59204836
138protein hydroxylation (GO:0018126)2.57979075
139regulation of sequestering of triglyceride (GO:0010889)2.56791987
140positive regulation of receptor recycling (GO:0001921)2.56523735
141regulation of establishment of planar polarity (GO:0090175)2.54855216
142negative regulation of cartilage development (GO:0061037)2.54294596
143regulation of apoptotic cell clearance (GO:2000425)2.53275003
144substrate adhesion-dependent cell spreading (GO:0034446)2.51519874
145cell proliferation involved in metanephros development (GO:0072203)2.51475465
146wound healing, spreading of epidermal cells (GO:0035313)2.51021787
147paraxial mesoderm development (GO:0048339)2.49770526
148blood vessel maturation (GO:0001955)2.48084965
149negative regulation of catenin import into nucleus (GO:0035414)2.47102828
150keratan sulfate catabolic process (GO:0042340)2.46642821
151regulation of axon extension involved in axon guidance (GO:0048841)2.45863881
152blood vessel endothelial cell migration (GO:0043534)2.44501913
153protein carboxylation (GO:0018214)2.39879867
154peptidyl-glutamic acid carboxylation (GO:0017187)2.39879867
155cochlea morphogenesis (GO:0090103)2.36209723
156cellular response to vitamin (GO:0071295)2.36187842
157muscle cell migration (GO:0014812)2.35799783
158regulation of integrin-mediated signaling pathway (GO:2001044)2.32951126
159cell-matrix adhesion (GO:0007160)2.32612218
160cell-substrate adhesion (GO:0031589)2.32567141
161protein localization to endosome (GO:0036010)2.32358811
162peptidyl-proline hydroxylation (GO:0019511)2.31730211

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.27673080
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.12060350
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.99159834
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.57043528
5EP300_21415370_ChIP-Seq_HL-1_Mouse3.16855794
6CLOCK_20551151_ChIP-Seq_293T_Human3.16520471
7TBX20_22080862_ChIP-Seq_HEART_Mouse2.58598214
8TBX20_22328084_ChIP-Seq_HEART_Mouse2.58598214
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.50402605
10ZNF263_19887448_ChIP-Seq_K562_Human2.43934816
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41115195
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.39854076
13EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.37958435
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28634829
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.25018015
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.17026366
17* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.11377846
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.11022046
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.09926210
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.95521719
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88988999
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.82038287
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.80228405
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79178992
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.77353503
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74332107
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.72642937
28MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.69915738
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69781773
30CJUN_26792858_Chip-Seq_BT549_Human1.69321632
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60729613
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59853042
33SOX9_24532713_ChIP-Seq_HFSC_Mouse1.56269174
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55671955
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53967533
36* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52366013
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.50912674
38CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.49564490
39RACK7_27058665_Chip-Seq_MCF-7_Human1.49485539
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.43324690
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41651338
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.41272461
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41108231
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39006855
45KDM2B_26808549_Chip-Seq_K562_Human1.38482442
46P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38091848
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37473522
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37075419
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.36548834
50LXR_22292898_ChIP-Seq_THP-1_Human1.35984761
51KDM2B_26808549_Chip-Seq_DND41_Human1.31987496
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31105459
53* ISL1_27105846_Chip-Seq_CPCs_Mouse1.28682615
54ATF3_27146783_Chip-Seq_COLON_Human1.28105154
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.26787910
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25718181
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23673283
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22709935
59DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21040155
60NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21033614
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20401325
62CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19780706
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19541551
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18836570
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18836570
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.17983474
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17103134
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17001412
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17001412
70SMC1_22415368_ChIP-Seq_MEFs_Mouse1.16916481
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16615737
72LXR_22158963_ChIP-Seq_LIVER_Mouse1.16355068
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16145124
74* BRD4_25478319_ChIP-Seq_HGPS_Human1.14617465
75MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12590963
76PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12247543
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.11315885
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11070762
79TP53_20018659_ChIP-ChIP_R1E_Mouse1.09993761
80CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09850493
81SA1_22415368_ChIP-Seq_MEFs_Mouse1.09174976
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08809905
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08693932
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08312274
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07779246
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07727653
87FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07443949
88TP53_23651856_ChIP-Seq_MEFs_Mouse1.07339867
89SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07092419
90ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06801964
91FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06651922
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05781312
93GATA4_21415370_ChIP-Seq_HL-1_Mouse1.05702080
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05456823
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05454963
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03431881
97AHR_22903824_ChIP-Seq_MCF-7_Human1.03250525
98TP53_22127205_ChIP-Seq_IMR90_Human1.02941727
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02569495
100SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02429367
101DROSHA_22980978_ChIP-Seq_HELA_Human1.02227457
102* TET1_21490601_ChIP-Seq_MESCs_Mouse1.02162975
103* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01991659
104FOXA2_19822575_ChIP-Seq_HepG2_Human1.01507702
105JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01167831
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00977707
107* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00829988
108TP63_22573176_ChIP-Seq_HFKS_Human0.99913938
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99842236
110SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99523703
111ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98777136
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98168985
113RNF2_27304074_Chip-Seq_ESCs_Mouse0.98149010
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98074538
115P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98051654
116ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97174959
117KDM2B_26808549_Chip-Seq_JURKAT_Human0.96275227
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95969893
119NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94938053
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94938053
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94361602
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94023404
123EED_16625203_ChIP-ChIP_MESCs_Mouse0.93431030
124TP53_16413492_ChIP-PET_HCT116_Human0.92451538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.82380798
2MP0002837_dystrophic_cardiac_calcinosis4.60731924
3MP0004084_abnormal_cardiac_muscle4.31410438
4MP0000751_myopathy4.08878087
5MP0005275_abnormal_skin_tensile3.32472500
6MP0004036_abnormal_muscle_relaxation3.02242594
7MP0003705_abnormal_hypodermis_morpholog2.95990784
8MP0004272_abnormal_basement_membrane2.92725461
9MP0004215_abnormal_myocardial_fiber2.88309879
10MP0003646_muscle_fatigue2.74857644
11MP0003279_aneurysm2.73807486
12MP0005330_cardiomyopathy2.71900850
13MP0000749_muscle_degeneration2.62818167
14MP0005503_abnormal_tendon_morphology2.55828049
15MP0000750_abnormal_muscle_regeneration2.44352860
16MP0005623_abnormal_meninges_morphology2.42256682
17MP0004087_abnormal_muscle_fiber2.35681015
18MP0001958_emphysema2.32565393
19MP0008775_abnormal_heart_ventricle2.13414610
20MP0006138_congestive_heart_failure2.11437077
21MP0002972_abnormal_cardiac_muscle2.08534946
22MP0010368_abnormal_lymphatic_system2.06818192
23MP0010630_abnormal_cardiac_muscle2.00297875
24MP0005620_abnormal_muscle_contractility1.94660021
25MP0001544_abnormal_cardiovascular_syste1.94242530
26MP0005385_cardiovascular_system_phenoty1.94242530
27MP0004130_abnormal_muscle_cell1.85065176
28MP0003566_abnormal_cell_adhesion1.83946367
29MP0003828_pulmonary_edema1.82563421
30MP0002106_abnormal_muscle_physiology1.70989235
31MP0003137_abnormal_impulse_conducting1.67071034
32MP0009384_cardiac_valve_regurgitation1.64638729
33MP0002269_muscular_atrophy1.64608320
34MP0004484_altered_response_of1.59299732
35MP0000759_abnormal_skeletal_muscle1.56755246
36MP0005670_abnormal_white_adipose1.56651044
37MP0004145_abnormal_muscle_electrophysio1.55352518
38MP0005369_muscle_phenotype1.55307775
39MP0005666_abnormal_adipose_tissue1.55081825
40MP0002108_abnormal_muscle_morphology1.54744522
41MP0001879_abnormal_lymphatic_vessel1.51568070
42MP0006054_spinal_hemorrhage1.51233857
43MP0001849_ear_inflammation1.48983449
44MP0000747_muscle_weakness1.45507269
45MP0004185_abnormal_adipocyte_glucose1.40336750
46MP0004233_abnormal_muscle_weight1.39713544
47MP0000013_abnormal_adipose_tissue1.37924189
48MP0000767_abnormal_smooth_muscle1.37556108
49MP0001542_abnormal_bone_strength1.36022374
50MP0005409_darkened_coat_color1.34194240
51MP0005058_abnormal_lysosome_morphology1.32973111
52MP0005375_adipose_tissue_phenotype1.28193490
53MP0000733_abnormal_muscle_development1.27845456
54MP0004085_abnormal_heartbeat1.26383155
55MP0002295_abnormal_pulmonary_circulatio1.26031962
56MP0003950_abnormal_plasma_membrane1.20924527
57MP0003045_fibrosis1.16432977
58MP0003091_abnormal_cell_migration1.13933211
59MP0002128_abnormal_blood_circulation1.11739114
60MP0009840_abnormal_foam_cell1.10914929
61MP0005508_abnormal_skeleton_morphology1.10842652
62MP0000762_abnormal_tongue_morphology1.10698668
63MP0000343_altered_response_to1.10120892
64MP0002254_reproductive_system_inflammat1.09688580
65MP0000003_abnormal_adipose_tissue1.08988872
66MP0000266_abnormal_heart_morphology1.07558217
67MP0001243_abnormal_dermal_layer1.06814138
68MP0002127_abnormal_cardiovascular_syste1.03924500
69MP0005171_absent_coat_pigmentation1.03468584
70MP0002060_abnormal_skin_morphology1.03113913
71MP0005165_increased_susceptibility_to1.00993953
72MP0002234_abnormal_pharynx_morphology1.00349565
73MP0003567_abnormal_fetal_cardiomyocyte0.99808525
74MP0005023_abnormal_wound_healing0.97118528
75MP0002933_joint_inflammation0.95536881
76MP0001348_abnormal_lacrimal_gland0.92019713
77MP0005167_abnormal_blood-brain_barrier0.91615756
78MP0002896_abnormal_bone_mineralization0.90806553
79MP0003283_abnormal_digestive_organ0.89514293
80MP0001915_intracranial_hemorrhage0.89443569
81MP0000462_abnormal_digestive_system0.89252679
82MP0002925_abnormal_cardiovascular_devel0.88054401
83MP0000534_abnormal_ureter_morphology0.87662046
84MP0003385_abnormal_body_wall0.85488949
85MP0001614_abnormal_blood_vessel0.85342708
86MP0001661_extended_life_span0.84726565
87MP0003221_abnormal_cardiomyocyte_apopto0.83470220
88MP0009780_abnormal_chondrocyte_physiolo0.83377355
89MP0010030_abnormal_orbit_morphology0.82230014
90MP0005257_abnormal_intraocular_pressure0.80996802
91MP0005390_skeleton_phenotype0.80571848
92MP0002932_abnormal_joint_morphology0.79689317
93MP0003191_abnormal_cellular_cholesterol0.79098051
94MP0002089_abnormal_postnatal_growth/wei0.78089468
95MP0000467_abnormal_esophagus_morphology0.76323980
96MP0002115_abnormal_skeleton_extremities0.75860671
97MP0000537_abnormal_urethra_morphology0.75706694
98MP0010352_gastrointestinal_tract_polyps0.73692057
99MP0004510_myositis0.73335204
100MP0003115_abnormal_respiratory_system0.73086614
101MP0009053_abnormal_anal_canal0.71987269
102MP0003941_abnormal_skin_development0.70841908
103MP0002332_abnormal_exercise_endurance0.70837044
104MP0005197_abnormal_uvea_morphology0.70518275
105MP0005595_abnormal_vascular_smooth0.69727780
106MP0002168_other_aberrant_phenotype0.69555648
107MP0002113_abnormal_skeleton_development0.68284585
108MP0001299_abnormal_eye_distance/0.68054943
109MP0000230_abnormal_systemic_arterial0.67270396
110MP0002116_abnormal_craniofacial_bone0.67170677
111MP0009250_abnormal_appendicular_skeleto0.67099926
112MP0000428_abnormal_craniofacial_morphol0.67007265
113MP0005164_abnormal_response_to0.66176704
114MP0000566_synostosis0.65921510
115MP0002877_abnormal_melanocyte_morpholog0.65557332
116MP0003942_abnormal_urinary_system0.63557998
117MP0009278_abnormal_bone_marrow0.61414571
118MP0005076_abnormal_cell_differentiation0.60734222
119MP0003300_gastrointestinal_ulcer0.59456046
120MP0005388_respiratory_system_phenotype0.59393142
121MP0002133_abnormal_respiratory_system0.59393142
122MP0003935_abnormal_craniofacial_develop0.58198508
123MP0000163_abnormal_cartilage_morphology0.55841840
124MP0002249_abnormal_larynx_morphology0.55295136
125MP0001784_abnormal_fluid_regulation0.54419224
126MP0004858_abnormal_nervous_system0.52726276

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.21503072
2Muscle fiber splitting (HP:0003555)5.15827492
3Increased connective tissue (HP:0009025)5.06793950
4Protrusio acetabuli (HP:0003179)4.97844682
5Premature rupture of membranes (HP:0001788)4.88822766
6Ventricular tachycardia (HP:0004756)4.71172071
7Ankle contracture (HP:0006466)4.38512151
8Hyporeflexia of lower limbs (HP:0002600)4.37365745
9Broad metatarsal (HP:0001783)4.36673801
10Right ventricular cardiomyopathy (HP:0011663)4.34600571
11Type 1 muscle fiber predominance (HP:0003803)4.06872174
12Atrial fibrillation (HP:0005110)3.92511595
13Lipoatrophy (HP:0100578)3.89262428
14Abnormality of the calf musculature (HP:0001430)3.88569211
15Calf muscle hypertrophy (HP:0008981)3.83858596
16Cerebral aneurysm (HP:0004944)3.83601001
17Aortic dissection (HP:0002647)3.73038939
18Exercise-induced muscle cramps (HP:0003710)3.72392306
19Primary atrial arrhythmia (HP:0001692)3.66777675
20Increased variability in muscle fiber diameter (HP:0003557)3.64517106
21Arterial tortuosity (HP:0005116)3.61564381
22Exercise-induced myalgia (HP:0003738)3.59878418
23Supraventricular arrhythmia (HP:0005115)3.56256536
24Supraventricular tachycardia (HP:0004755)3.49107701
25Difficulty running (HP:0009046)3.48889131
26Shallow orbits (HP:0000586)3.41831922
27Muscle hypertrophy of the lower extremities (HP:0008968)3.41622450
28Aortic aneurysm (HP:0004942)3.31229359
29Abnormality of skeletal muscle fiber size (HP:0012084)3.24851554
30Difficulty climbing stairs (HP:0003551)3.23017507
31Mildly elevated creatine phosphokinase (HP:0008180)3.12128347
32Spinal rigidity (HP:0003306)3.08599875
33Abnormality of the left ventricular outflow tract (HP:0011103)3.06539403
34Subaortic stenosis (HP:0001682)3.06539403
35EMG: myopathic abnormalities (HP:0003458)2.99902602
36Vertebral compression fractures (HP:0002953)2.99843488
37Atrophic scars (HP:0001075)2.94022584
38Bundle branch block (HP:0011710)2.92953599
39Asymmetric septal hypertrophy (HP:0001670)2.91808979
40Dilated cardiomyopathy (HP:0001644)2.91472943
41Bladder diverticulum (HP:0000015)2.85556877
42Biconcave vertebral bodies (HP:0004586)2.83466849
43Myoglobinuria (HP:0002913)2.80343932
44Syncope (HP:0001279)2.73906324
45Aneurysm (HP:0002617)2.68199873
46Fragile skin (HP:0001030)2.66575208
47Prolonged QT interval (HP:0001657)2.65830059
48Soft skin (HP:0000977)2.65645160
49Ulnar bowing (HP:0003031)2.60597787
50Mitral valve prolapse (HP:0001634)2.57911922
51Ventricular arrhythmia (HP:0004308)2.56613394
52Myotonia (HP:0002486)2.55816260
53Mitral regurgitation (HP:0001653)2.51477798
54Lymphangioma (HP:0100764)2.48348976
55Atrioventricular block (HP:0001678)2.46657724
56Wrist flexion contracture (HP:0001239)2.43776753
57Abnormal atrioventricular conduction (HP:0005150)2.43646289
58Hypoplastic ischia (HP:0003175)2.42469864
59Dilatation of the ascending aorta (HP:0005111)2.41667100
60Scapular winging (HP:0003691)2.41242243
61Aortic regurgitation (HP:0001659)2.40532542
62Mitral stenosis (HP:0001718)2.40043313
63Heart block (HP:0012722)2.38308361
64Palpitations (HP:0001962)2.35701020
65Follicular hyperkeratosis (HP:0007502)2.31746308
66Bowel diverticulosis (HP:0005222)2.31452016
67Abnormality of the acetabulum (HP:0003170)2.25582454
68Abnormal delivery (HP:0001787)2.23556093
69Joint stiffness (HP:0001387)2.20922460
70Osteolytic defects of the hand bones (HP:0009699)2.19633885
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.19633885
72Round ear (HP:0100830)2.16745806
73Limb-girdle muscle atrophy (HP:0003797)2.16347800
74Distal lower limb muscle weakness (HP:0009053)2.13951306
75Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.13778858
76Pulmonary artery stenosis (HP:0004415)2.13513873
77Facial diplegia (HP:0001349)2.11361832
78Peritonitis (HP:0002586)2.11266495
79Abnormality of the ischium (HP:0003174)2.10867859
80Short nail (HP:0001799)2.10553135
81Spondylolisthesis (HP:0003302)2.06474660
82Distal lower limb amyotrophy (HP:0008944)2.05789974
83Ventricular fibrillation (HP:0001663)2.05585797
84Ectopia lentis (HP:0001083)2.05101016
85Hip contracture (HP:0003273)2.04145449
86Limb-girdle muscle weakness (HP:0003325)2.03924548
87Cervical subluxation (HP:0003308)2.02485649
88Infantile muscular hypotonia (HP:0008947)2.01674743
89Blue sclerae (HP:0000592)1.99685945
90Rectal prolapse (HP:0002035)1.97491763
91Thin bony cortex (HP:0002753)1.97027976
92Wormian bones (HP:0002645)1.96703974
93Aortic valve stenosis (HP:0001650)1.96524366
94Rhabdomyolysis (HP:0003201)1.96506967
95Hyperacusis (HP:0010780)1.96425385
96Broad face (HP:0000283)1.96164245
97Coronal craniosynostosis (HP:0004440)1.96048607
98Neonatal short-limb short stature (HP:0008921)1.95453026
99Natal tooth (HP:0000695)1.93005547
100Disproportionate tall stature (HP:0001519)1.92483369
101Slender build (HP:0001533)1.91253082
102Coxa vara (HP:0002812)1.91061816
103Abnormality of dentin (HP:0010299)1.90521546
104Osteoarthritis (HP:0002758)1.88589611
105Hyperextensible skin (HP:0000974)1.87776789
106Generalized amyotrophy (HP:0003700)1.87715912
107Limited hip movement (HP:0008800)1.87011101
108Genu recurvatum (HP:0002816)1.85569844
109Breech presentation (HP:0001623)1.84099515
110Testicular atrophy (HP:0000029)1.83509796
111Muscular dystrophy (HP:0003560)1.81987598
112Vascular tortuosity (HP:0004948)1.80917089
113Short hallux (HP:0010109)1.80290608
114Overgrowth (HP:0001548)1.79851106
115Venous abnormality (HP:0002624)1.79315890
116Abnormality of the 4th metacarpal (HP:0010012)1.79201427
117Camptodactyly of toe (HP:0001836)1.78248580
118Turricephaly (HP:0000262)1.77389989
119Neck muscle weakness (HP:0000467)1.77317281
120Ulnar deviation of the wrist (HP:0003049)1.77036609
121Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76970950
122Inguinal hernia (HP:0000023)1.76606974
123Abnormality of complement system (HP:0005339)1.75757656
124Abnormality of carpal bone ossification (HP:0006257)1.75460898
125Nonimmune hydrops fetalis (HP:0001790)1.74742771
126Wide anterior fontanel (HP:0000260)1.73533362
127Deep venous thrombosis (HP:0002625)1.72838519
128Elbow flexion contracture (HP:0002987)1.72789221
129Knee flexion contracture (HP:0006380)1.72420642
130Advanced eruption of teeth (HP:0006288)1.71983697
131Mild short stature (HP:0003502)1.71709725
132Abnormal EKG (HP:0003115)1.71562377
133Distal upper limb amyotrophy (HP:0007149)1.71318424
134Upper limb amyotrophy (HP:0009129)1.71318424
135Abnormal ossification of hand bones (HP:0005921)1.70960485
136Muscle fiber inclusion bodies (HP:0100299)1.70481767
137Long toe (HP:0010511)1.70405649
138Aplasia/Hypoplasia of the hallux (HP:0008362)1.70108795
139Joint laxity (HP:0001388)1.69669463
140Obstructive sleep apnea (HP:0002870)1.69385394
141Hypoventilation (HP:0002791)1.69224504
142Ovoid vertebral bodies (HP:0003300)1.68309292
143Achilles tendon contracture (HP:0001771)1.68192155
144Cupped ribs (HP:0000887)1.67695844
145Cardiovascular calcification (HP:0011915)1.66102985
146Complement deficiency (HP:0004431)1.64710430

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.80785721
2TRIB34.14918582
3MYLK3.37025658
4LMTK23.08251834
5PKN22.91081359
6TIE12.74940139
7DMPK2.67061020
8PDGFRA2.63260710
9RIPK12.35330439
10PHKG22.33158224
11PHKG12.33158224
12DDR22.26868162
13PDK42.07566453
14PDK32.07566453
15EPHB22.06620870
16SIK12.03948033
17OBSCN2.01633913
18TGFBR22.00601216
19LATS11.80576275
20TESK11.69145530
21PDK21.56590743
22ERN11.54138815
23MAP3K61.43900696
24MST1R1.43278250
25PAK31.40297110
26PIK3CA1.39778009
27SMG11.31521702
28PTK61.31048060
29FER1.28356838
30LATS21.27360280
31AKT31.20933150
32PAK21.19394760
33ROCK11.18865762
34EPHB11.18127196
35KDR1.17148216
36BCKDK1.16552272
37ILK1.15505348
38PRKD11.14950098
39LIMK11.12459633
40CAMK1D1.09146838
41PAK41.08380123
42EEF2K1.08304760
43WNK41.06048230
44MAPKAPK31.03775549
45NEK11.02982497
46TRPM70.99886357
47ICK0.98356674
48PTK2B0.97100497
49LRRK20.94538890
50CDC42BPA0.90565077
51MOS0.89097182
52MTOR0.88709531
53PDGFRB0.86235122
54CAMK1G0.85453585
55ERBB40.84292828
56PTK20.84192503
57MAP3K30.81614064
58MAPK70.80892901
59BMX0.79829010
60MARK20.79412256
61MAP2K30.77934503
62ROCK20.76984945
63PRKD30.75634693
64MAP3K70.75374467
65STK38L0.73866889
66MET0.71931920
67FGFR40.66894489
68STK240.66085220
69ABL20.65811936
70MAP3K100.65352700
71DAPK30.61809251
72PRKAA20.59893940
73EPHA30.59510975
74PRPF4B0.59453391
75TGFBR10.59269621
76WNK10.58990346
77FGFR10.58490560
78MAPK120.56208028
79FGFR20.55514111
80NTRK10.52737830
81EPHA20.52445201
82STK380.52348276
83PRKAA10.52250261
84CAMK2D0.52100182
85RET0.51604923
86PDPK10.49709941
87CAMK2G0.49185207
88PRKCH0.48303038
89STK390.47955204
90PINK10.47855284
91NEK90.47734784
92STK30.47270751
93MAP2K10.46785029
94TYRO30.46516249
95MUSK0.45016978
96FLT30.44873166
97PRKD20.43576951
98DYRK1B0.42726933
99RPS6KL10.42317931
100RPS6KC10.42317931
101CAMK40.41537405
102CDK120.40471151
103MAPK150.40444982
104PRKG20.40136948
105FGFR30.39150505
106IRAK30.37118640
107KSR20.36501102
108RPS6KA60.35373373
109MAPK40.34431607
110JAK10.34408734
111MELK0.33493406
112AKT20.33069110
113STK40.32088154
114ERBB20.31087496
115RPS6KA20.30931472
116ZAP700.29913992
117PRKACB0.29303624
118PIK3CG0.28047050
119PRKCE0.27801078
120HIPK20.27702237
121PIM20.27640790
122GSK3A0.27262012
123PAK60.27214738
124SRC0.26094258

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.82498376
2Dilated cardiomyopathy_Homo sapiens_hsa054143.67724329
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.61100104
4* ECM-receptor interaction_Homo sapiens_hsa045123.13588161
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.97507463
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.87750367
7* Focal adhesion_Homo sapiens_hsa045102.53257198
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.48121510
9Cardiac muscle contraction_Homo sapiens_hsa042602.30230713
10Other glycan degradation_Homo sapiens_hsa005112.04048102
11Propanoate metabolism_Homo sapiens_hsa006402.01745877
12Fatty acid degradation_Homo sapiens_hsa000712.01121438
13Viral myocarditis_Homo sapiens_hsa054161.91371798
14Complement and coagulation cascades_Homo sapiens_hsa046101.88620555
15Fatty acid metabolism_Homo sapiens_hsa012121.77545579
16Protein digestion and absorption_Homo sapiens_hsa049741.75403968
17Adherens junction_Homo sapiens_hsa045201.69587996
18* Amoebiasis_Homo sapiens_hsa051461.57363046
19Proteoglycans in cancer_Homo sapiens_hsa052051.57214330
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53533102
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.49634662
22Prion diseases_Homo sapiens_hsa050201.48412082
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.44114701
24Carbon metabolism_Homo sapiens_hsa012001.39133331
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35399906
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35301384
27Tight junction_Homo sapiens_hsa045301.33989553
28PPAR signaling pathway_Homo sapiens_hsa033201.33221341
29Insulin resistance_Homo sapiens_hsa049311.32360863
30* Small cell lung cancer_Homo sapiens_hsa052221.28241498
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.25857543
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13746384
33Fatty acid biosynthesis_Homo sapiens_hsa000611.12624894
34Hippo signaling pathway_Homo sapiens_hsa043901.09758889
35Basal cell carcinoma_Homo sapiens_hsa052171.08718220
36Insulin signaling pathway_Homo sapiens_hsa049101.04250402
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02983975
38Lysine degradation_Homo sapiens_hsa003101.01886076
39AMPK signaling pathway_Homo sapiens_hsa041521.00960841
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.00485555
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.00236790
42Notch signaling pathway_Homo sapiens_hsa043300.99818377
43Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98877108
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.98720371
45* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.97838199
46Pyruvate metabolism_Homo sapiens_hsa006200.96548528
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.95142382
48Bladder cancer_Homo sapiens_hsa052190.94483605
49Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93903723
50Dorso-ventral axis formation_Homo sapiens_hsa043200.93566411
51HIF-1 signaling pathway_Homo sapiens_hsa040660.89667442
52Glucagon signaling pathway_Homo sapiens_hsa049220.89177368
53TGF-beta signaling pathway_Homo sapiens_hsa043500.88027320
54Galactose metabolism_Homo sapiens_hsa000520.87537276
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86589001
56MicroRNAs in cancer_Homo sapiens_hsa052060.86402167
57Phenylalanine metabolism_Homo sapiens_hsa003600.86065356
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.85523219
59Chronic myeloid leukemia_Homo sapiens_hsa052200.81073392
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79817693
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79316480
62Renal cell carcinoma_Homo sapiens_hsa052110.76795946
63Lysosome_Homo sapiens_hsa041420.76365279
64Platelet activation_Homo sapiens_hsa046110.75601441
65Hedgehog signaling pathway_Homo sapiens_hsa043400.75284053
66Rap1 signaling pathway_Homo sapiens_hsa040150.74154342
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70897439
68* Pathways in cancer_Homo sapiens_hsa052000.69968227
69Tyrosine metabolism_Homo sapiens_hsa003500.68059990
70Arginine biosynthesis_Homo sapiens_hsa002200.66574397
71Oxytocin signaling pathway_Homo sapiens_hsa049210.66450300
72Melanoma_Homo sapiens_hsa052180.66190133
73Renin secretion_Homo sapiens_hsa049240.65609733
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65598995
75Thyroid cancer_Homo sapiens_hsa052160.64841214
76mTOR signaling pathway_Homo sapiens_hsa041500.64601949
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64256938
78Axon guidance_Homo sapiens_hsa043600.64253777
79VEGF signaling pathway_Homo sapiens_hsa043700.64062844
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62889959
81Estrogen signaling pathway_Homo sapiens_hsa049150.60982601
82Pentose phosphate pathway_Homo sapiens_hsa000300.60705238
83Fructose and mannose metabolism_Homo sapiens_hsa000510.60215297
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59576836
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.58788737
86Gastric acid secretion_Homo sapiens_hsa049710.58015099
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57505071
88Gap junction_Homo sapiens_hsa045400.57404003
89Glioma_Homo sapiens_hsa052140.56630406
90Starch and sucrose metabolism_Homo sapiens_hsa005000.54910666
91Parkinsons disease_Homo sapiens_hsa050120.54731151
92Melanogenesis_Homo sapiens_hsa049160.54312410
93* Toxoplasmosis_Homo sapiens_hsa051450.53762030
94cAMP signaling pathway_Homo sapiens_hsa040240.52117396
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51823893
96Ovarian steroidogenesis_Homo sapiens_hsa049130.51692233
97Endometrial cancer_Homo sapiens_hsa052130.50805788
98Renin-angiotensin system_Homo sapiens_hsa046140.50474284
99Choline metabolism in cancer_Homo sapiens_hsa052310.50136023
100Endocytosis_Homo sapiens_hsa041440.49624979
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49069781
102Alzheimers disease_Homo sapiens_hsa050100.48777687
103Malaria_Homo sapiens_hsa051440.47674573
104Histidine metabolism_Homo sapiens_hsa003400.46640786
105N-Glycan biosynthesis_Homo sapiens_hsa005100.46627314
106Pertussis_Homo sapiens_hsa051330.46377680
107Pancreatic cancer_Homo sapiens_hsa052120.45820929
108ABC transporters_Homo sapiens_hsa020100.45815095
109Type II diabetes mellitus_Homo sapiens_hsa049300.45199394
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.44767696
111ErbB signaling pathway_Homo sapiens_hsa040120.44545771
112Biosynthesis of amino acids_Homo sapiens_hsa012300.43247957
113Vitamin B6 metabolism_Homo sapiens_hsa007500.43117524
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43073056
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42322328
116Calcium signaling pathway_Homo sapiens_hsa040200.41955114
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41713250
118Wnt signaling pathway_Homo sapiens_hsa043100.40495037
119GnRH signaling pathway_Homo sapiens_hsa049120.40489294
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39575978
121Prostate cancer_Homo sapiens_hsa052150.38850359
122FoxO signaling pathway_Homo sapiens_hsa040680.36086288
123HTLV-I infection_Homo sapiens_hsa051660.36049346
124Butanoate metabolism_Homo sapiens_hsa006500.35053983
125Thyroid hormone synthesis_Homo sapiens_hsa049180.34128215
126Bile secretion_Homo sapiens_hsa049760.33316222

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