LAMB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.11702146
2bundle of His cell to Purkinje myocyte communication (GO:0086069)6.99138766
3surfactant homeostasis (GO:0043129)5.99447099
4mesodermal cell differentiation (GO:0048333)5.01297884
5regulation of transforming growth factor beta2 production (GO:0032909)4.85665629
6chemical homeostasis within a tissue (GO:0048875)4.84329456
7* cell-substrate junction assembly (GO:0007044)4.67827480
8protein localization to endosome (GO:0036010)4.61291858
9positive regulation of epidermal cell differentiation (GO:0045606)4.49452212
10regulation of water loss via skin (GO:0033561)4.44641435
11positive regulation of hair follicle development (GO:0051798)4.40630522
12positive regulation of hair cycle (GO:0042635)4.40630522
13thyroid hormone generation (GO:0006590)4.28506925
14gap junction assembly (GO:0016264)4.06930079
15establishment of skin barrier (GO:0061436)4.04653462
16renal filtration (GO:0097205)3.96540685
17negative regulation of keratinocyte proliferation (GO:0010839)3.95117815
18polarized epithelial cell differentiation (GO:0030859)3.85820512
19negative regulation of chondrocyte differentiation (GO:0032331)3.78477352
20keratinization (GO:0031424)3.77767627
21hepatocyte apoptotic process (GO:0097284)3.77084919
22regulation of hair cycle (GO:0042634)3.73902206
23pattern specification involved in kidney development (GO:0061004)3.71197530
24thyroid hormone metabolic process (GO:0042403)3.70629068
25odontogenesis of dentin-containing tooth (GO:0042475)3.69102955
26multicellular organismal water homeostasis (GO:0050891)3.64100909
27tooth mineralization (GO:0034505)3.62230928
28lung lobe morphogenesis (GO:0060463)3.62100197
29L-serine transport (GO:0015825)3.60841184
30keratinocyte proliferation (GO:0043616)3.60174946
31positive regulation of keratinocyte differentiation (GO:0045618)3.57950992
32cell adhesion mediated by integrin (GO:0033627)3.51691854
33regulation of epidermis development (GO:0045682)3.48933577
34regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.48633596
35negative regulation of cell fate specification (GO:0009996)3.44801845
36keratinocyte differentiation (GO:0030216)3.44546375
37odontogenesis (GO:0042476)3.43674843
38atrioventricular valve morphogenesis (GO:0003181)3.41858334
39cellular copper ion homeostasis (GO:0006878)3.41036630
40cell-substrate adherens junction assembly (GO:0007045)3.34657059
41focal adhesion assembly (GO:0048041)3.34657059
42renal system development (GO:0072001)3.27032142
43interferon-gamma secretion (GO:0072643)3.26303349
44mammary gland epithelial cell proliferation (GO:0033598)3.24771918
45regulation of glomerular filtration (GO:0003093)3.24469911
46activation of Rac GTPase activity (GO:0032863)3.18395050
47serine transport (GO:0032329)3.17709339
48branching involved in salivary gland morphogenesis (GO:0060445)3.15198503
49dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.15181290
50positive regulation of odontogenesis (GO:0042482)3.12454825
51negative regulation of epidermis development (GO:0045683)3.11816712
52branching involved in mammary gland duct morphogenesis (GO:0060444)3.03793728
53COPI coating of Golgi vesicle (GO:0048205)3.03749228
54Golgi transport vesicle coating (GO:0048200)3.03749228
55regulation of keratinocyte differentiation (GO:0045616)3.03551918
56* epidermis development (GO:0008544)3.02965360
57water homeostasis (GO:0030104)2.98118165
58semaphorin-plexin signaling pathway (GO:0071526)2.97119600
59ventricular cardiac muscle cell action potential (GO:0086005)2.97082224
60epithelial cell-cell adhesion (GO:0090136)2.95039963
61renal system process involved in regulation of blood volume (GO:0001977)2.93849098
62negative regulation of cell fate commitment (GO:0010454)2.93040630
63regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.90988454
64hair cycle (GO:0042633)2.90266761
65molting cycle (GO:0042303)2.90266761
66ectoderm development (GO:0007398)2.89252928
67adherens junction assembly (GO:0034333)2.88704870
68keratinocyte development (GO:0003334)2.87722448
69membrane raft organization (GO:0031579)2.86858640
70virion attachment to host cell (GO:0019062)2.86855160
71adhesion of symbiont to host cell (GO:0044650)2.86855160
72mammary gland development (GO:0030879)2.85127911
73regulation of chemokine secretion (GO:0090196)2.84278245
74regulation of transforming growth factor beta production (GO:0071634)2.83889042
75tight junction assembly (GO:0070830)2.82463095
76intermediate filament cytoskeleton organization (GO:0045104)2.80187169
77regulation of hippo signaling (GO:0035330)2.79945299
78positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.78288494
79cellular response to vitamin D (GO:0071305)2.78129879
80intermediate filament organization (GO:0045109)2.78105547
81skin morphogenesis (GO:0043589)2.77994216
82intestinal epithelial cell development (GO:0060576)2.76713892
83maintenance of gastrointestinal epithelium (GO:0030277)2.76653739
84plasma membrane repair (GO:0001778)2.76413942
85adherens junction organization (GO:0034332)2.75033341
86negative regulation of anoikis (GO:2000811)2.74935841
87sulfate transmembrane transport (GO:1902358)2.73836134
88peptidyl-tyrosine autophosphorylation (GO:0038083)2.73508475
89glial cell proliferation (GO:0014009)2.72004113
90regulation of metalloenzyme activity (GO:0048552)2.70977444
91regulation of cardioblast differentiation (GO:0051890)2.70826928
92positive regulation of positive chemotaxis (GO:0050927)2.69350471
93negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.67956443
94intermediate filament-based process (GO:0045103)2.67525362
95morphogenesis of embryonic epithelium (GO:0016331)2.67351194
96wound healing (GO:0042060)2.67066988
97mammary gland alveolus development (GO:0060749)2.66947949
98regulation of integrin activation (GO:0033623)2.65847013
99membrane tubulation (GO:0097320)2.65803687
100epidermal cell differentiation (GO:0009913)2.62314540
101regulation of epidermal cell differentiation (GO:0045604)2.62089677
102regulation of endothelial cell chemotaxis (GO:2001026)2.61977636
103growth hormone receptor signaling pathway (GO:0060396)2.61707754
104wound healing, spreading of epidermal cells (GO:0035313)2.61358409
105negative regulation of cartilage development (GO:0061037)2.60454448
106regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.60100014
107positive regulation of osteoblast proliferation (GO:0033690)2.58619956
108regulation of keratinocyte proliferation (GO:0010837)2.57931425
109epithelial structure maintenance (GO:0010669)2.56973226
110peptide cross-linking (GO:0018149)2.56458170
111regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.55590563
112planar cell polarity pathway involved in neural tube closure (GO:0090179)2.54676967
113hypotonic response (GO:0006971)2.54450031
114lung vasculature development (GO:0060426)2.53445764
115regulation of positive chemotaxis (GO:0050926)2.53161307
116detection of bacterium (GO:0016045)2.51963032
117regulation of podosome assembly (GO:0071801)2.51878304
118regulation of interleukin-8 secretion (GO:2000482)2.50554630
119regulation of cell fate specification (GO:0042659)2.49175136
120regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.49106487
121* cell junction assembly (GO:0034329)2.47116754
122regulation of collagen biosynthetic process (GO:0032965)2.47115320
123regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.45829221
124epithelial cell differentiation involved in prostate gland development (GO:0060742)2.45625404
125lung secretory cell differentiation (GO:0061140)2.43591282
126negative regulation of protein autophosphorylation (GO:0031953)2.43065218
127positive regulation of p38MAPK cascade (GO:1900745)2.41942905
128calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.41343024
129O-glycan processing (GO:0016266)2.40559500
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.39824429
131positive regulation of interleukin-8 secretion (GO:2000484)2.39764513
132detection of other organism (GO:0098543)2.38360683
133* cell junction organization (GO:0034330)2.38000527
134* endodermal cell differentiation (GO:0035987)2.37483121
135positive regulation of collagen biosynthetic process (GO:0032967)2.37349745
136skin development (GO:0043588)2.36622285
137positive regulation of epidermis development (GO:0045684)2.36549323
138adhesion of symbiont to host (GO:0044406)2.35392056
139one-carbon compound transport (GO:0019755)2.34603712
140thyroid gland development (GO:0030878)2.32659330
141regulation of hair follicle development (GO:0051797)2.32630726
142lung-associated mesenchyme development (GO:0060484)2.31017784
143positive regulation of endothelial cell apoptotic process (GO:2000353)2.30638349
144lateral sprouting from an epithelium (GO:0060601)2.30527302
145gland morphogenesis (GO:0022612)2.30163028
146regulation of cardioblast proliferation (GO:0003264)2.29716769
147regulation of secondary heart field cardioblast proliferation (GO:0003266)2.29716769
148regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.29427771
149* extracellular matrix disassembly (GO:0022617)2.28939157
150establishment of planar polarity (GO:0001736)2.27533553
151establishment of tissue polarity (GO:0007164)2.27533553
152* hemidesmosome assembly (GO:0031581)13.5930081

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.35077819
2* SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.21091239
3ESR1_21235772_ChIP-Seq_MCF-7_Human2.79996967
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.65879778
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.50319027
6SOX9_24532713_ChIP-Seq_HFSC_Mouse2.36256258
7CDX2_20551321_ChIP-Seq_CACO-2_Human2.33637070
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.17960340
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16998790
10* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.08000740
11* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.08000740
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01554450
13TP63_17297297_ChIP-ChIP_HaCaT_Human11.4609473
14SOX2_20726797_ChIP-Seq_SW620_Human1.90069793
15ZNF217_24962896_ChIP-Seq_MCF-7_Human1.89564011
16* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.85368868
17PPAR_26484153_Chip-Seq_NCI-H1993_Human1.80265681
18SOX2_27498859_Chip-Seq_STOMACH_Mouse1.80262511
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73633824
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66634522
21GATA4_25053715_ChIP-Seq_YYC3_Human1.66588197
22FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64091750
23* KLF5_25053715_ChIP-Seq_YYC3_Human1.63122215
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.62613285
25CJUN_26792858_Chip-Seq_BT549_Human1.59475932
26AHR_22903824_ChIP-Seq_MCF-7_Human1.54913333
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52579737
28* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46901266
29ZNF263_19887448_ChIP-Seq_K562_Human1.44866152
30* GATA2_21666600_ChIP-Seq_HMVEC_Human1.43722301
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43438325
32* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42265694
33* RUNX1_27514584_Chip-Seq_MCF-7_Human1.41978079
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.41658308
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41540660
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39060720
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37408913
38* GATA6_25053715_ChIP-Seq_YYC3_Human1.36782379
39ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.35607569
40* RACK7_27058665_Chip-Seq_MCF-7_Human1.34202254
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33416919
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28940999
43TCF4_18268006_ChIP-ChIP_LS174T_Human1.28580876
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28383669
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26530172
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25552265
47* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25538134
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.23307102
49* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22481127
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22292393
51* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18648957
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14427726
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14035920
54CLOCK_20551151_ChIP-Seq_293T_Human1.13776866
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13724392
56* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12600433
57AR_21909140_ChIP-Seq_LNCAP_Human1.12359499
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09558892
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.09507073
60TP53_22127205_ChIP-Seq_IMR90_Human1.09278745
61TP53_18474530_ChIP-ChIP_U2OS_Human1.09196910
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09036759
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05892863
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05462444
65* TP63_23658742_ChIP-Seq_EP156T_Human1.05232641
66GATA3_24758297_ChIP-Seq_MCF-7_Human1.04822512
67JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04376123
68LXR_22292898_ChIP-Seq_THP-1_Human1.02776219
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01841638
70AR_21572438_ChIP-Seq_LNCaP_Human1.01423203
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00047042
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00005232
73PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95923308
74UBF1/2_26484160_Chip-Seq_HMECs_Human0.95579162
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95144465
76EGR1_19032775_ChIP-ChIP_M12_Human0.94152544
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93712833
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93667460
79FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93601933
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93413721
81* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92999281
82SMAD_19615063_ChIP-ChIP_OVARY_Human0.92798329
83EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92729594
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90964958
85* TBX20_22080862_ChIP-Seq_HEART_Mouse0.88364104
86* TBX20_22328084_ChIP-Seq_HEART_Mouse0.88364104
87* ATF3_27146783_Chip-Seq_COLON_Human0.88324553
88SMAD3_21741376_ChIP-Seq_HESCs_Human0.88077512
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85617574
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85278204
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84165833
92TP53_16413492_ChIP-PET_HCT116_Human0.84147778
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83656556
94ERG_21242973_ChIP-ChIP_JURKAT_Human0.81946035
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81848175
96RXR_22108803_ChIP-Seq_LS180_Human0.81374249
97IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80667177
98TET1_21490601_ChIP-Seq_MESCs_Mouse0.79382756
99PPARA_22158963_ChIP-Seq_LIVER_Mouse0.79196179
100FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77842836
101AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77812573
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.77404819
103* TP63_22573176_ChIP-Seq_HFKS_Human0.77196437
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76289950
105KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76143263
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75944355
107NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75944355
108GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75418146
109EGR1_19374776_ChIP-ChIP_THP-1_Human0.74923597
110* LXR_22158963_ChIP-Seq_LIVER_Mouse0.74467662
111ISL1_27105846_Chip-Seq_CPCs_Mouse0.73662803
112RUNX_20019798_ChIP-Seq_JUKART_Human0.73606877
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.72775969
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.72112294
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.72075803
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.72073915
117* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.71626611
118TP53_23651856_ChIP-Seq_MEFs_Mouse0.70907804
119KDM2B_26808549_Chip-Seq_K562_Human0.70756669
120* ELK3_25401928_ChIP-Seq_HUVEC_Human0.69960096
121* BRD4_25478319_ChIP-Seq_HGPS_Human0.69255248
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.69024676
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.67814979
124NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.67225633
125GATA2_19941826_ChIP-Seq_K562_Human0.66923747
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.66770648
127IRF8_22096565_ChIP-ChIP_GC-B_Human0.66075715
128* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65299134
129* VDR_24787735_ChIP-Seq_THP-1_Human0.65239579
130* RXR_22158963_ChIP-Seq_LIVER_Mouse0.62010813
131TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.61919677
132* SA1_27219007_Chip-Seq_ERYTHROID_Human0.61639303
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.61218213
134ELK4_26923725_Chip-Seq_MESODERM_Mouse0.61037688
135CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.60363956
136FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.57923028
137NANOG_18692474_ChIP-Seq_MEFs_Mouse0.55914279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.48048275
2MP0000383_abnormal_hair_follicle4.11132875
3MP0010678_abnormal_skin_adnexa3.86751128
4MP0002254_reproductive_system_inflammat3.85540894
5MP0002796_impaired_skin_barrier3.44753426
6MP0000579_abnormal_nail_morphology3.27874646
7MP0005275_abnormal_skin_tensile3.20648837
8MP0001849_ear_inflammation2.98868860
9MP0004782_abnormal_surfactant_physiolog2.88074997
10MP0003453_abnormal_keratinocyte_physiol2.77919377
11MP0002098_abnormal_vibrissa_morphology2.67464865
12* MP0002060_abnormal_skin_morphology2.65150593
13MP0005409_darkened_coat_color2.54523714
14MP0001216_abnormal_epidermal_layer2.51856612
15MP0000566_synostosis2.46052601
16MP0000467_abnormal_esophagus_morphology2.36998965
17MP0000537_abnormal_urethra_morphology2.34504550
18MP0003566_abnormal_cell_adhesion2.30393792
19MP0005501_abnormal_skin_physiology2.26877260
20* MP0000762_abnormal_tongue_morphology2.19277635
21MP0003941_abnormal_skin_development2.02978961
22MP0003705_abnormal_hypodermis_morpholog2.00454916
23MP0000462_abnormal_digestive_system1.92001897
24MP0008004_abnormal_stomach_pH1.89823081
25* MP0010771_integument_phenotype1.86897954
26MP0004272_abnormal_basement_membrane1.78931853
27MP0001346_abnormal_lacrimal_gland1.78328933
28MP0004947_skin_inflammation1.73048599
29MP0005360_urolithiasis1.70882526
30MP0000377_abnormal_hair_follicle1.70474802
31MP0004264_abnormal_extraembryonic_tissu1.69691276
32MP0000538_abnormal_urinary_bladder1.67901633
33MP0000427_abnormal_hair_cycle1.59582909
34MP0001666_abnormal_nutrient_absorption1.50677798
35MP0010155_abnormal_intestine_physiology1.49260364
36MP0005023_abnormal_wound_healing1.49100575
37MP0008260_abnormal_autophagy1.48249178
38MP0003315_abnormal_perineum_morphology1.45756116
39MP0001958_emphysema1.43417902
40MP0000647_abnormal_sebaceous_gland1.40861216
41MP0000678_abnormal_parathyroid_gland1.38655935
42MP0010352_gastrointestinal_tract_polyps1.38452759
43MP0003300_gastrointestinal_ulcer1.34479864
44MP0003950_abnormal_plasma_membrane1.33563724
45MP0000627_abnormal_mammary_gland1.31152133
46MP0005257_abnormal_intraocular_pressure1.21169815
47MP0004381_abnormal_hair_follicle1.20726902
48MP0001191_abnormal_skin_condition1.17082804
49MP0003866_abnormal_defecation1.16004006
50MP0009384_cardiac_valve_regurgitation1.14291439
51MP0003806_abnormal_nucleotide_metabolis1.13408336
52MP0000470_abnormal_stomach_morphology1.12608066
53MP0009840_abnormal_foam_cell1.11915354
54MP0001873_stomach_inflammation1.08446460
55MP0000681_abnormal_thyroid_gland1.07022830
56* MP0009931_abnormal_skin_appearance1.05159429
57MP0006054_spinal_hemorrhage1.04726636
58MP0005083_abnormal_biliary_tract1.04586559
59MP0000613_abnormal_salivary_gland1.03590369
60MP0001881_abnormal_mammary_gland0.99948736
61MP0002877_abnormal_melanocyte_morpholog0.99891957
62MP0001851_eye_inflammation0.97959154
63MP0002138_abnormal_hepatobiliary_system0.97943664
64MP0009053_abnormal_anal_canal0.97791492
65MP0010030_abnormal_orbit_morphology0.96450529
66MP0005381_digestive/alimentary_phenotyp0.95713749
67MP0003045_fibrosis0.93669588
68MP0003724_increased_susceptibility_to0.92966316
69MP0003329_amyloid_beta_deposits0.91804153
70MP0005451_abnormal_body_composition0.91470274
71MP0001664_abnormal_digestion0.91081447
72MP0000516_abnormal_urinary_system0.88159664
73MP0005367_renal/urinary_system_phenotyp0.88159664
74MP0005076_abnormal_cell_differentiation0.88087500
75MP0009785_altered_susceptibility_to0.87932576
76MP0000465_gastrointestinal_hemorrhage0.87013076
77MP0000432_abnormal_head_morphology0.86437883
78MP0008789_abnormal_olfactory_epithelium0.85416720
79* MP0002234_abnormal_pharynx_morphology0.83961037
80MP0004185_abnormal_adipocyte_glucose0.83434664
81MP0008995_early_reproductive_senescence0.82910011
82MP0000477_abnormal_intestine_morphology0.82763879
83MP0001663_abnormal_digestive_system0.79310035
84MP0002896_abnormal_bone_mineralization0.77807130
85MP0000858_altered_metastatic_potential0.77580258
86MP0009780_abnormal_chondrocyte_physiolo0.77388881
87MP0002089_abnormal_postnatal_growth/wei0.76419065
88MP0002233_abnormal_nose_morphology0.74546591
89MP0000367_abnormal_coat/_hair0.73951734
90MP0000490_abnormal_crypts_of0.73293661
91MP0003935_abnormal_craniofacial_develop0.71083736
92MP0005197_abnormal_uvea_morphology0.70593075
93MP0002282_abnormal_trachea_morphology0.70538735
94MP0000003_abnormal_adipose_tissue0.70006282
95MP0005248_abnormal_Harderian_gland0.69707769
96MP0002277_abnormal_respiratory_mucosa0.68450558
97MP0002177_abnormal_outer_ear0.67324897
98MP0003448_altered_tumor_morphology0.67186968
99MP0000013_abnormal_adipose_tissue0.67156603
100MP0005164_abnormal_response_to0.66842393
101MP0001790_abnormal_immune_system0.66523551
102MP0005387_immune_system_phenotype0.66523551
103MP0004858_abnormal_nervous_system0.66518545
104MP0001243_abnormal_dermal_layer0.65670227
105MP0000685_abnormal_immune_system0.65661376
106MP0010368_abnormal_lymphatic_system0.63819231
107MP0003436_decreased_susceptibility_to0.62146956
108MP0005388_respiratory_system_phenotype0.61053132
109MP0002133_abnormal_respiratory_system0.61053132
110MP0009764_decreased_sensitivity_to0.59522737
111MP0003091_abnormal_cell_migration0.59086714
112MP0006138_congestive_heart_failure0.58660291
113MP0001299_abnormal_eye_distance/0.58451844
114MP0005621_abnormal_cell_physiology0.58332276
115MP0001879_abnormal_lymphatic_vessel0.57278599
116MP0003191_abnormal_cellular_cholesterol0.57182582
117MP0005623_abnormal_meninges_morphology0.56617565
118MP0008438_abnormal_cutaneous_collagen0.56160734
119MP0000733_abnormal_muscle_development0.56151578
120MP0005165_increased_susceptibility_to0.55989489
121MP0001340_abnormal_eyelid_morphology0.55955653
122MP0004019_abnormal_vitamin_homeostasis0.54977523
123MP0005193_abnormal_anterior_eye0.54510147
124MP0009250_abnormal_appendicular_skeleto0.54473861
125MP0005166_decreased_susceptibility_to0.54250144
126MP0003755_abnormal_palate_morphology0.53752568
127MP0001661_extended_life_span0.53522097
128MP0000750_abnormal_muscle_regeneration0.51890225
129MP0005375_adipose_tissue_phenotype0.51180551
130MP0001765_abnormal_ion_homeostasis0.48471844
131MP0002697_abnormal_eye_size0.47384661
132MP0002006_tumorigenesis0.45308282
133MP0005330_cardiomyopathy0.44928076
134MP0003075_altered_response_to0.44252762
135MP0005499_abnormal_olfactory_system0.44026137
136MP0005394_taste/olfaction_phenotype0.44026137
137MP0002111_abnormal_tail_morphology0.43978724
138MP0003828_pulmonary_edema0.42989710

Predicted human phenotypes

RankGene SetZ-score
1* Milia (HP:0001056)9.56976796
2* Onycholysis (HP:0001806)9.38641555
3* Fragile nails (HP:0001808)7.75695290
4Amelogenesis imperfecta (HP:0000705)7.75282649
5* Atrophic scars (HP:0001075)7.52346475
6Right ventricular cardiomyopathy (HP:0011663)6.46932543
7* Plantar hyperkeratosis (HP:0007556)6.44821822
8Pili torti (HP:0003777)6.03514330
9Interstitial pulmonary disease (HP:0006530)4.87565572
10* Nail dystrophy (HP:0008404)4.23195694
11Thick nail (HP:0001805)4.15290986
12Abnormal hair laboratory examination (HP:0003328)3.88146225
13Fragile skin (HP:0001030)3.84372760
14Selective tooth agenesis (HP:0001592)3.84359098
15* Hypoplasia of dental enamel (HP:0006297)3.83960480
16Aplasia cutis congenita (HP:0001057)3.82482571
17* Abnormal blistering of the skin (HP:0008066)3.74030004
18Woolly hair (HP:0002224)3.72759491
19Palmoplantar hyperkeratosis (HP:0000972)3.64637594
20Palmar hyperkeratosis (HP:0010765)3.43850474
21Alopecia of scalp (HP:0002293)3.42907315
22Sparse scalp hair (HP:0002209)3.30386999
23Esophageal atresia (HP:0002032)3.29656180
24Ridged nail (HP:0001807)3.17857958
25Hypotrichosis (HP:0001006)3.05278311
26Popliteal pterygium (HP:0009756)3.04378629
27Curly hair (HP:0002212)3.04255518
28Pustule (HP:0200039)2.91275235
29Ureteral stenosis (HP:0000071)2.85075810
30Dry hair (HP:0011359)2.78680927
31Ventricular tachycardia (HP:0004756)2.71931560
32Fatigable weakness (HP:0003473)2.69115274
33Abnormality of the neuromuscular junction (HP:0003398)2.69115274
34Amniotic constriction ring (HP:0009775)2.64252709
35Abnormality of placental membranes (HP:0011409)2.64252709
36Hypoplastic labia majora (HP:0000059)2.62435125
37Ureteral obstruction (HP:0006000)2.60078530
38Hyperactive renin-angiotensin system (HP:0000841)2.59321120
39Distal lower limb muscle weakness (HP:0009053)2.58491774
40Abnormality of the gastric mucosa (HP:0004295)2.56773143
41Abnormality of the salivary glands (HP:0010286)2.51110404
42Micronodular cirrhosis (HP:0001413)2.51063818
43Pterygium (HP:0001059)2.41119364
44Broad face (HP:0000283)2.40999661
45Short nail (HP:0001799)2.39821039
46Abnormality of the labia majora (HP:0012881)2.35782263
47Neurofibrillary tangles (HP:0002185)2.35547785
48Lip pit (HP:0100267)2.32632692
49Oral leukoplakia (HP:0002745)2.31526053
50Absent eyelashes (HP:0000561)2.26224295
51Breast hypoplasia (HP:0003187)2.25504438
52Cheilitis (HP:0100825)2.21293070
53Epidermoid cyst (HP:0200040)2.15803940
54Ectropion (HP:0000656)2.15182051
55* Dehydration (HP:0001944)2.13190640
56Abnormality of nail color (HP:0100643)2.02682492
57Blepharitis (HP:0000498)2.02636775
58Down-sloping shoulders (HP:0200021)2.02230334
59Cerebral inclusion bodies (HP:0100314)2.01262530
60Trismus (HP:0000211)2.01057522
61Premature loss of primary teeth (HP:0006323)1.98011739
62Vascular calcification (HP:0004934)1.95924118
63Erythema (HP:0010783)1.94259825
64Advanced eruption of teeth (HP:0006288)1.91818113
65Bronchomalacia (HP:0002780)1.89966299
66Abnormality of the axillary hair (HP:0100134)1.89623155
67Abnormality of secondary sexual hair (HP:0009888)1.89623155
68* Skin ulcer (HP:0200042)1.89442357
69Corneal erosion (HP:0200020)1.88029176
70Tubulointerstitial fibrosis (HP:0005576)1.87875397
71Focal segmental glomerulosclerosis (HP:0000097)1.87689604
72Cervical subluxation (HP:0003308)1.87315345
73* Hypodontia (HP:0000668)1.86086978
74Laryngomalacia (HP:0001601)1.85515969
75Increased connective tissue (HP:0009025)1.84577659
76Unilateral renal agenesis (HP:0000122)1.84552763
77Anonychia (HP:0001798)1.83310674
78Mildly elevated creatine phosphokinase (HP:0008180)1.82485651
79Tetany (HP:0001281)1.81766785
80Acanthosis nigricans (HP:0000956)1.81691625
81Flat acetabular roof (HP:0003180)1.81308623
82Weak cry (HP:0001612)1.80036259
83Broad metatarsal (HP:0001783)1.79711533
84Respiratory distress (HP:0002098)1.79448348
85Cardiovascular calcification (HP:0011915)1.77625534
86Increased IgE level (HP:0003212)1.77075719
87Abnormality of the distal phalanges of the toes (HP:0010182)1.76721697
88Goiter (HP:0000853)1.76185363
89Glomerulosclerosis (HP:0000096)1.74428092
90Gastrointestinal atresia (HP:0002589)1.74198302
91Abnormality of the 2nd finger (HP:0004100)1.72111301
92Ankyloglossia (HP:0010296)1.71119272
93* Hyperhidrosis (HP:0000975)1.70074383
94Chronic otitis media (HP:0000389)1.69864722
95Septate vagina (HP:0001153)1.68937687
96Oligodontia (HP:0000677)1.68225563
97Arterial tortuosity (HP:0005116)1.66646491
98Esophageal varix (HP:0002040)1.66001141
99Follicular hyperkeratosis (HP:0007502)1.65824931
100Corneal dystrophy (HP:0001131)1.65751532
101Rectal prolapse (HP:0002035)1.65407077
102Malnutrition (HP:0004395)1.65305115
103* Carious teeth (HP:0000670)1.64610690
104Tibial bowing (HP:0002982)1.64188388
105Hypoplasia of the uterus (HP:0000013)1.63775129
106Hyperphosphatemia (HP:0002905)1.61443484
107Stomach cancer (HP:0012126)1.60101232
108Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.60096176
109Multifactorial inheritance (HP:0001426)1.59705006
110Hoarse voice (HP:0001609)1.59633074
111Deviation of the thumb (HP:0009603)1.58476759
112Osteolytic defects of the phalanges of the hand (HP:0009771)1.57852558
113Osteolytic defects of the hand bones (HP:0009699)1.57852558
114Distal lower limb amyotrophy (HP:0008944)1.57447506
115Palmoplantar keratoderma (HP:0000982)1.56754018
116* Death in infancy (HP:0001522)1.56535944
117Abnormality of the dental root (HP:0006486)1.56425319
118Taurodontia (HP:0000679)1.56425319
119Abnormality of permanent molar morphology (HP:0011071)1.56425319
120Nasolacrimal duct obstruction (HP:0000579)1.56350869
121Shallow orbits (HP:0000586)1.56065639
122Subacute progressive viral hepatitis (HP:0006572)1.55758805
123Poikiloderma (HP:0001029)1.55406629
124Difficulty climbing stairs (HP:0003551)1.55066931
125Ureteral duplication (HP:0000073)1.55014251
126Abnormality of the distal phalanx of the thumb (HP:0009617)1.54568644
127Ulnar bowing (HP:0003031)1.51860538
128Xerostomia (HP:0000217)1.51740600
129Parakeratosis (HP:0001036)1.51291463
130Natal tooth (HP:0000695)1.50670591
131Sparse eyelashes (HP:0000653)1.50584078
132* Abnormality of the fingernails (HP:0001231)1.49417573
133Periodontitis (HP:0000704)1.46902955
134Abnormality of the middle phalanges of the toes (HP:0010183)1.45679770
135Aplasia involving bones of the upper limbs (HP:0009823)1.44573074
136Aplasia of the phalanges of the hand (HP:0009802)1.44573074
137Aplasia involving bones of the extremities (HP:0009825)1.44573074
138Syncope (HP:0001279)1.43928410
139Short hallux (HP:0010109)1.43396512
140Abnormality of oral frenula (HP:0000190)1.41775040

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.28613739
2MST43.63557420
3MST1R3.53477403
4ARAF3.44031599
5LATS13.05465417
6NTRK12.90932080
7EPHB22.75513914
8FER2.58750896
9MAP3K32.52947031
10EPHB12.43403264
11MAP3K92.38737499
12PIM22.24124408
13FLT31.93318477
14EPHA31.90349091
15TGFBR11.85981576
16PTK61.85440170
17TRPM71.81688232
18MAP2K21.80374914
19FGFR41.80225507
20MAP3K21.80136866
21RIPK11.78419727
22ERN11.74114410
23STK241.69914430
24FRK1.69307727
25SIK11.66403500
26LRRK21.63695226
27NME21.56778077
28RPS6KB21.55848456
29LATS21.52616783
30FGFR21.51865764
31TGFBR21.49971415
32PIK3CA1.49956070
33TTN1.48851100
34LMTK21.43421147
35PTK21.43226963
36STK101.26813473
37TESK11.25011672
38MAPK151.21722634
39MAP3K141.21022712
40MAPKAPK31.20734772
41PAK41.19847307
42SMG11.18141752
43MYLK1.16468318
44TRIB31.15126953
45KSR21.13093009
46BRAF1.08240204
47MET1.05184550
48MAP2K11.02461919
49MAP3K11.00983715
50IRAK31.00542434
51PRKG20.99848950
52FGFR30.98824763
53PKN20.93721317
54STK30.92124845
55MAP3K130.91926227
56TYK20.91033344
57MAP3K60.91008233
58NUAK10.89221136
59NME10.88809377
60STK380.86518564
61CHUK0.86410584
62MAP3K70.84551071
63MOS0.84462746
64STK38L0.84072129
65MAP2K60.83860299
66EEF2K0.83380528
67TBK10.80971448
68IKBKE0.79603030
69BMX0.79103803
70FGFR10.78156919
71ICK0.76866882
72RPS6KA40.75738039
73CDK120.74609157
74PDGFRB0.74060452
75JAK10.73809883
76ERBB20.73140877
77MATK0.72505386
78ZAP700.71838854
79CDK60.70643383
80GRK10.70092341
81DMPK0.69112642
82RAF10.67016972
83PRPF4B0.66053634
84PRKCI0.62484852
85JAK30.60958296
86MAP3K80.60568681
87NLK0.57851071
88CSK0.56747192
89ABL20.56436325
90ERBB30.55839703
91DDR20.50721308
92KSR10.50106638
93CSF1R0.49431493
94MTOR0.49007675
95DAPK20.48484320
96PDGFRA0.47930984
97MAPKAPK20.47687478
98CDC42BPA0.45562480
99PRKD10.45212888
100PHKG10.45172086
101PHKG20.45172086
102BCR0.44931867
103TAOK10.44689196
104PRKD20.43841902
105GSK3A0.42894760
106MAP3K120.42548999
107PBK0.41044139
108BTK0.39733739
109PAK30.39664852
110PAK20.37914843
111PRKCE0.37776582
112IKBKB0.36202628
113RPS6KA20.36055945
114ITK0.35847869
115ILK0.35206514
116ABL10.35203922
117RPS6KA10.34328973
118SRC0.33349222
119TIE10.32985414
120SIK30.32609828
121DYRK1B0.32348871
122PTK2B0.32031009
123ROCK10.30854135
124ERBB40.29419920
125MAP3K100.26759034
126IRAK10.26670341
127RET0.26428395
128RPS6KC10.26104867
129RPS6KL10.26104867
130RPS6KA60.24464347
131PRKAA20.23886801
132ROCK20.23353378
133ADRBK10.19876685
134WNK10.19303255
135SGK30.18616513
136CAMK2G0.16865900
137INSR0.15981150
138IGF1R0.15058058
139NEK60.14788890
140FGR0.13951860
141EIF2AK20.11343590

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045123.21582778
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.39481991
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.35748264
4Mineral absorption_Homo sapiens_hsa049782.31293595
5Adherens junction_Homo sapiens_hsa045202.28690546
6* Small cell lung cancer_Homo sapiens_hsa052222.15865432
7Basal cell carcinoma_Homo sapiens_hsa052171.87728978
8* Toxoplasmosis_Homo sapiens_hsa051451.84043978
9Leukocyte transendothelial migration_Homo sapiens_hsa046701.83402060
10* Focal adhesion_Homo sapiens_hsa045101.75833777
11ErbB signaling pathway_Homo sapiens_hsa040121.73569730
12* Amoebiasis_Homo sapiens_hsa051461.71263812
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.70081587
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69226380
15Central carbon metabolism in cancer_Homo sapiens_hsa052301.68781536
16Bladder cancer_Homo sapiens_hsa052191.68690167
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.68579322
18p53 signaling pathway_Homo sapiens_hsa041151.66437878
19Tight junction_Homo sapiens_hsa045301.64647518
20Hippo signaling pathway_Homo sapiens_hsa043901.62485567
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.61723261
22Protein digestion and absorption_Homo sapiens_hsa049741.54648203
23Caffeine metabolism_Homo sapiens_hsa002321.50031684
24Sulfur metabolism_Homo sapiens_hsa009201.49758480
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.49582037
26Proteoglycans in cancer_Homo sapiens_hsa052051.49470473
27Steroid biosynthesis_Homo sapiens_hsa001001.46896336
28Galactose metabolism_Homo sapiens_hsa000521.42966061
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35467423
30Prion diseases_Homo sapiens_hsa050201.34620110
31Hematopoietic cell lineage_Homo sapiens_hsa046401.29747151
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28197787
33TNF signaling pathway_Homo sapiens_hsa046681.26342892
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25995645
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24057391
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23209620
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.22377127
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21507894
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19531655
40Sphingolipid metabolism_Homo sapiens_hsa006001.17011386
41Hepatitis C_Homo sapiens_hsa051601.14550865
42Pancreatic secretion_Homo sapiens_hsa049721.11226941
43Histidine metabolism_Homo sapiens_hsa003401.09801309
44Leishmaniasis_Homo sapiens_hsa051401.08878901
45Hedgehog signaling pathway_Homo sapiens_hsa043401.07805766
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07695476
47N-Glycan biosynthesis_Homo sapiens_hsa005101.05230199
48Fat digestion and absorption_Homo sapiens_hsa049751.05071404
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02314395
50Chemical carcinogenesis_Homo sapiens_hsa052041.00562160
51Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98839277
52Endometrial cancer_Homo sapiens_hsa052130.98198440
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97896677
54Malaria_Homo sapiens_hsa051440.97299951
55* Pathways in cancer_Homo sapiens_hsa052000.96267665
56Thyroid cancer_Homo sapiens_hsa052160.96253630
57Pertussis_Homo sapiens_hsa051330.95845496
58Thyroid hormone synthesis_Homo sapiens_hsa049180.93468664
59Dilated cardiomyopathy_Homo sapiens_hsa054140.93293589
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89954741
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.89944409
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89185611
63Fructose and mannose metabolism_Homo sapiens_hsa000510.88296662
64Notch signaling pathway_Homo sapiens_hsa043300.87254971
65Glioma_Homo sapiens_hsa052140.86343577
66Dorso-ventral axis formation_Homo sapiens_hsa043200.86251912
67Salmonella infection_Homo sapiens_hsa051320.85380989
68Endocytosis_Homo sapiens_hsa041440.84512034
69Pancreatic cancer_Homo sapiens_hsa052120.83268263
70TGF-beta signaling pathway_Homo sapiens_hsa043500.82962411
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.82593606
72Insulin signaling pathway_Homo sapiens_hsa049100.82216581
73Autoimmune thyroid disease_Homo sapiens_hsa053200.81747515
74Acute myeloid leukemia_Homo sapiens_hsa052210.81263533
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81243408
76Influenza A_Homo sapiens_hsa051640.79895306
77Chronic myeloid leukemia_Homo sapiens_hsa052200.78315729
78Osteoclast differentiation_Homo sapiens_hsa043800.78266082
79Apoptosis_Homo sapiens_hsa042100.78023499
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77717431
81Fatty acid biosynthesis_Homo sapiens_hsa000610.77562010
82Gastric acid secretion_Homo sapiens_hsa049710.76811751
83GnRH signaling pathway_Homo sapiens_hsa049120.76700137
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75776616
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73005322
86Viral myocarditis_Homo sapiens_hsa054160.72794130
87Shigellosis_Homo sapiens_hsa051310.72225030
88Prolactin signaling pathway_Homo sapiens_hsa049170.72148571
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71617395
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69771162
91Axon guidance_Homo sapiens_hsa043600.69633765
92MicroRNAs in cancer_Homo sapiens_hsa052060.68283676
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67935595
94Fatty acid degradation_Homo sapiens_hsa000710.67758426
95Inositol phosphate metabolism_Homo sapiens_hsa005620.67607436
96* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65813596
97Rap1 signaling pathway_Homo sapiens_hsa040150.65688794
98Glycerolipid metabolism_Homo sapiens_hsa005610.65313416
99Lysosome_Homo sapiens_hsa041420.63812900
100Glutathione metabolism_Homo sapiens_hsa004800.63282880
101Non-small cell lung cancer_Homo sapiens_hsa052230.62689877
102Vitamin digestion and absorption_Homo sapiens_hsa049770.61744068
103ABC transporters_Homo sapiens_hsa020100.61335615
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.60459229
105Platelet activation_Homo sapiens_hsa046110.59395085
106Wnt signaling pathway_Homo sapiens_hsa043100.58833070
107Estrogen signaling pathway_Homo sapiens_hsa049150.58551076
108Other glycan degradation_Homo sapiens_hsa005110.58068588
109VEGF signaling pathway_Homo sapiens_hsa043700.56033481
110Rheumatoid arthritis_Homo sapiens_hsa053230.54610862
111Phenylalanine metabolism_Homo sapiens_hsa003600.54493406
112Insulin resistance_Homo sapiens_hsa049310.54178285
113Prostate cancer_Homo sapiens_hsa052150.54018822
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53650499
115Linoleic acid metabolism_Homo sapiens_hsa005910.53006850
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.52397421
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52286614
118Melanogenesis_Homo sapiens_hsa049160.51481481
119Measles_Homo sapiens_hsa051620.51442685
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51199010
121beta-Alanine metabolism_Homo sapiens_hsa004100.49904204
122Antigen processing and presentation_Homo sapiens_hsa046120.49252988
123Melanoma_Homo sapiens_hsa052180.47411755
124Legionellosis_Homo sapiens_hsa051340.47233336
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.47156704
126Bile secretion_Homo sapiens_hsa049760.46833724
127Salivary secretion_Homo sapiens_hsa049700.46035393
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45554509
129Tuberculosis_Homo sapiens_hsa051520.45498108
130Renal cell carcinoma_Homo sapiens_hsa052110.44516301
131Vibrio cholerae infection_Homo sapiens_hsa051100.44204706
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.43205855
133Pentose phosphate pathway_Homo sapiens_hsa000300.43115800
134HIF-1 signaling pathway_Homo sapiens_hsa040660.40716562
135Arginine biosynthesis_Homo sapiens_hsa002200.40245861
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33271606
137AMPK signaling pathway_Homo sapiens_hsa041520.32558320
138Glucagon signaling pathway_Homo sapiens_hsa049220.30605859
139Starch and sucrose metabolism_Homo sapiens_hsa005000.29644576
140Vitamin B6 metabolism_Homo sapiens_hsa007500.29593528
141Viral carcinogenesis_Homo sapiens_hsa052030.27914684

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