LAMC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polarized epithelial cell differentiation (GO:0030859)7.00542333
2basement membrane organization (GO:0071711)6.77507210
3establishment of apical/basal cell polarity (GO:0035089)6.18693746
4retina vasculature morphogenesis in camera-type eye (GO:0061299)6.16463659
5regulation of cardioblast differentiation (GO:0051890)5.51857854
6establishment or maintenance of monopolar cell polarity (GO:0061339)5.26584453
7establishment of monopolar cell polarity (GO:0061162)5.26584453
8embryonic foregut morphogenesis (GO:0048617)5.18934427
9endocardial cushion development (GO:0003197)4.95686751
10atrioventricular valve morphogenesis (GO:0003181)4.77515024
11regulation of gene silencing by RNA (GO:0060966)4.56900923
12regulation of posttranscriptional gene silencing (GO:0060147)4.56900923
13regulation of gene silencing by miRNA (GO:0060964)4.56900923
14regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.53540832
15branching involved in salivary gland morphogenesis (GO:0060445)4.50521909
16skin morphogenesis (GO:0043589)4.38072349
17endodermal cell differentiation (GO:0035987)4.32061296
18peptidyl-proline hydroxylation (GO:0019511)4.29098950
19paraxial mesoderm development (GO:0048339)4.07423745
20regulation of hippo signaling (GO:0035330)4.05493579
21protein hydroxylation (GO:0018126)4.03129815
22negative regulation of cell fate specification (GO:0009996)3.99291350
23endoderm formation (GO:0001706)3.94973302
24regulation of transforming growth factor beta2 production (GO:0032909)3.89301792
25epithelial cell-cell adhesion (GO:0090136)3.82346005
26regulation of SMAD protein import into nucleus (GO:0060390)3.81442074
27hippo signaling (GO:0035329)3.80917127
28glomerular basement membrane development (GO:0032836)3.80599116
29sequestering of extracellular ligand from receptor (GO:0035581)3.77216991
30collagen fibril organization (GO:0030199)3.76465734
31protein heterotrimerization (GO:0070208)3.74315813
32cell migration involved in heart development (GO:0060973)3.72990160
33COPI coating of Golgi vesicle (GO:0048205)3.71798638
34Golgi transport vesicle coating (GO:0048200)3.71798638
35positive regulation of SMAD protein import into nucleus (GO:0060391)3.71183827
36negative regulation of chondrocyte differentiation (GO:0032331)3.58841993
37* substrate adhesion-dependent cell spreading (GO:0034446)3.49256023
38establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.49165217
39kidney mesenchyme development (GO:0072074)3.48268606
40substrate-dependent cell migration (GO:0006929)3.46294153
41planar cell polarity pathway involved in neural tube closure (GO:0090179)3.41077556
42establishment of epithelial cell polarity (GO:0090162)3.40217330
43cardiac myofibril assembly (GO:0055003)3.37011140
44morphogenesis of an epithelial sheet (GO:0002011)3.35755833
45plasma membrane repair (GO:0001778)3.34118907
46extracellular fibril organization (GO:0043206)3.33138336
47atrial septum morphogenesis (GO:0060413)3.32974282
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.30260712
49gastrulation with mouth forming second (GO:0001702)3.30227375
50vascular endothelial growth factor signaling pathway (GO:0038084)3.28928633
51protein retention in ER lumen (GO:0006621)3.27501587
52regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.24169945
53organ formation (GO:0048645)3.22844051
54renal system development (GO:0072001)3.22061964
55regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.22000576
56positive regulation of endothelial cell apoptotic process (GO:2000353)3.21506738
57regulation of cell fate specification (GO:0042659)3.21448164
58metanephric mesenchyme development (GO:0072075)3.20865879
59blood vessel maturation (GO:0001955)3.15808082
60mesenchymal-epithelial cell signaling (GO:0060638)3.15619361
61positive regulation of blood vessel endothelial cell migration (GO:0043536)3.15249519
62chondrocyte proliferation (GO:0035988)3.13848299
63multicellular organismal catabolic process (GO:0044243)3.13300832
644-hydroxyproline metabolic process (GO:0019471)3.12100789
65cardiac right ventricle morphogenesis (GO:0003215)3.09793729
66negative regulation of fatty acid transport (GO:2000192)3.08378324
67mesodermal cell differentiation (GO:0048333)3.05518999
68adherens junction assembly (GO:0034333)3.04447280
69chondrocyte development (GO:0002063)3.02284168
70axon extension involved in axon guidance (GO:0048846)3.00452657
71neuron projection extension involved in neuron projection guidance (GO:1902284)3.00452657
72bone trabecula formation (GO:0060346)3.00278527
73regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.98502781
74extracellular matrix assembly (GO:0085029)2.97848088
75protein localization to endosome (GO:0036010)2.97485808
76renal filtration (GO:0097205)2.96971193
77anterior/posterior axis specification, embryo (GO:0008595)2.94799917
78regulation of tight junction assembly (GO:2000810)2.93975937
79dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.92797204
80regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.92651425
81response to follicle-stimulating hormone (GO:0032354)2.90998938
82vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.89658330
83wound healing, spreading of cells (GO:0044319)2.89107298
84barbed-end actin filament capping (GO:0051016)2.88640024
85regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.88579867
86* cell-substrate junction assembly (GO:0007044)2.88576927
87wound healing, spreading of epidermal cells (GO:0035313)2.87248103
88epithelial cell fate commitment (GO:0072148)2.86042387
89fibril organization (GO:0097435)2.85305164
90collagen metabolic process (GO:0032963)2.84188186
91heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.84074908
92* extracellular matrix organization (GO:0030198)2.83555614
93nuclear pore complex assembly (GO:0051292)2.83210683
94mRNA transcription (GO:0009299)2.82603138
95* extracellular structure organization (GO:0043062)2.82467547
96* extracellular matrix disassembly (GO:0022617)2.81978298
97type B pancreatic cell proliferation (GO:0044342)2.81760625
98cellular response to vitamin (GO:0071295)2.81274617
99glomerular filtration (GO:0003094)2.79554622
100mRNA transcription from RNA polymerase II promoter (GO:0042789)2.78748011
101blood vessel endothelial cell migration (GO:0043534)2.78471396
102insulin-like growth factor receptor signaling pathway (GO:0048009)2.77835342
103apoptotic cell clearance (GO:0043277)2.77598994
104endothelial cell morphogenesis (GO:0001886)2.77341768
105nuclear pore organization (GO:0006999)2.76425896
106cell migration involved in sprouting angiogenesis (GO:0002042)2.75568046
107muscle hypertrophy in response to stress (GO:0003299)2.75010607
108cardiac muscle adaptation (GO:0014887)2.75010607
109cardiac muscle hypertrophy in response to stress (GO:0014898)2.75010607
110desmosome organization (GO:0002934)2.74276160
111stress fiber assembly (GO:0043149)2.73854658
112negative regulation of smooth muscle cell migration (GO:0014912)2.72068517
113positive regulation of osteoblast proliferation (GO:0033690)2.70489579
114multicellular organismal macromolecule metabolic process (GO:0044259)2.69370471
115venous blood vessel morphogenesis (GO:0048845)2.69244390
116focal adhesion assembly (GO:0048041)2.69019462
117cell-substrate adherens junction assembly (GO:0007045)2.69019462
118lung-associated mesenchyme development (GO:0060484)2.68838067
119regulation of plasminogen activation (GO:0010755)2.67890724
120muscle cell migration (GO:0014812)2.67628788
121lymph vessel development (GO:0001945)2.66902149
122Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.66723755
123mesenchyme development (GO:0060485)2.66280785
124cytoskeletal anchoring at plasma membrane (GO:0007016)2.64673477
125collagen catabolic process (GO:0030574)2.64633052
126sprouting angiogenesis (GO:0002040)2.64022819
127protein localization to cell surface (GO:0034394)2.63906529
128COPII vesicle coating (GO:0048208)2.63095023
129epithelial tube branching involved in lung morphogenesis (GO:0060441)2.62723075
130establishment or maintenance of bipolar cell polarity (GO:0061245)2.62455055
131establishment or maintenance of apical/basal cell polarity (GO:0035088)2.62455055
132cardiac muscle hypertrophy (GO:0003300)2.61742703
133cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.60676432
134heart trabecula formation (GO:0060347)2.60637401
135formation of primary germ layer (GO:0001704)2.59187506
136regulation of establishment of planar polarity (GO:0090175)2.58344455
137cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.57767605
138trabecula formation (GO:0060343)2.57758239
139pre-miRNA processing (GO:0031054)2.57220187
140regulation of translational fidelity (GO:0006450)2.56962449
141cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.56562742
142notochord development (GO:0030903)2.56484276
143* hemidesmosome assembly (GO:0031581)2.56481813
144sarcomere organization (GO:0045214)2.55837846
145glomerular visceral epithelial cell development (GO:0072015)2.54260590
146cell adhesion mediated by integrin (GO:0033627)2.54127929
147positive regulation of endothelial cell migration (GO:0010595)2.53766607
148negative regulation of cell fate commitment (GO:0010454)2.53708167
149multicellular organismal metabolic process (GO:0044236)2.53630070
150cellular response to vitamin D (GO:0071305)2.52985223
151negative regulation of cartilage development (GO:0061037)2.52884290
152cell migration involved in gastrulation (GO:0042074)2.52735692
153striated muscle hypertrophy (GO:0014897)2.52211949
154cochlea morphogenesis (GO:0090103)2.50723240
155regulation of mesoderm development (GO:2000380)2.50221638
156lymphangiogenesis (GO:0001946)2.50050727
157ventricular septum development (GO:0003281)2.48973695
158gap junction assembly (GO:0016264)2.48956514
159myofibril assembly (GO:0030239)2.47234019
160hyaluronan catabolic process (GO:0030214)2.45549570
161regulation of chondrocyte differentiation (GO:0032330)2.45014589

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.94042689
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.72990491
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.31572821
4ZNF263_19887448_ChIP-Seq_K562_Human3.30648371
5E2F7_22180533_ChIP-Seq_HELA_Human3.29861539
6SALL4_18804426_ChIP-ChIP_XEN_Mouse3.03158714
7CLOCK_20551151_ChIP-Seq_293T_Human3.02601072
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.78580009
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.78053843
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.66962780
11* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66485075
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.64144319
13ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.63448206
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.47091607
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.41359167
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.30277796
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.26792940
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.24055856
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.24055856
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.24055856
21* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.17363875
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.12751845
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.08807619
24TCF3_18692474_ChIP-Seq_MEFs_Mouse2.01754931
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.99952914
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.98138746
27SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.90309441
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.90286942
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.89039034
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.88494528
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.87017204
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.86308109
33* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79489756
34* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77011889
35* AR_21909140_ChIP-Seq_LNCAP_Human1.76547464
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.72756986
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72214243
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69579494
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.67850461
40* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63458846
41* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63137377
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59398164
43* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58350036
44* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57997542
45BRD4_25478319_ChIP-Seq_HGPS_Human1.54004683
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53169705
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.50474825
48TBX20_22080862_ChIP-Seq_HEART_Mouse1.50141688
49TBX20_22328084_ChIP-Seq_HEART_Mouse1.50141688
50ATF3_27146783_Chip-Seq_COLON_Human1.50131113
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49729893
52* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48415960
53* UBF1/2_26484160_Chip-Seq_HMECs_Human1.47878827
54* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45754784
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.45453011
56TCF3_18692474_ChIP-Seq_MESCs_Mouse1.45231931
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44230851
58TP53_18474530_ChIP-ChIP_U2OS_Human1.42161526
59* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40004116
60* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40004116
61NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.39666769
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39129030
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37663141
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36991262
65ISL1_27105846_Chip-Seq_CPCs_Mouse1.35321466
66* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34638306
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.34439801
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32443403
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32188604
70TP53_16413492_ChIP-PET_HCT116_Human1.31731689
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31138022
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30771717
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.30361963
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.30185265
75NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.30085190
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29551682
77* CJUN_26792858_Chip-Seq_BT549_Human1.29486614
78* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29040176
79* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29040176
80* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.28842235
81DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28024932
82* ESR2_21235772_ChIP-Seq_MCF-7_Human1.27914700
83* RACK7_27058665_Chip-Seq_MCF-7_Human1.27651123
84EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27452549
85RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27452549
86* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25628047
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24609620
88* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.21697443
89KDM2B_26808549_Chip-Seq_DND41_Human1.21406428
90CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17914015
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17693142
92* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17032389
93TP53_23651856_ChIP-Seq_MEFs_Mouse1.16097510
94NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.15494135
95TP53_22127205_ChIP-Seq_IMR90_Human1.15477313
96* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13622922
97MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12826272
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11700315
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10883038
100STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10723117
101* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10353649
102TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.08838700
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08632412
104SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08508797
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07808684
106SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07180653
107PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.06245006
108SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05763687
109SA1_22415368_ChIP-Seq_MEFs_Mouse1.05537322
110UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05455548
111MYC_22102868_ChIP-Seq_BL_Human1.04754635
112* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.04743432
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04543033
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04043267
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04026427
116TP53_20018659_ChIP-ChIP_R1E_Mouse1.03925841
117* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03904446
118SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02472468
119NANOG_18692474_ChIP-Seq_MEFs_Mouse1.02377536
120* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02313315
121* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02245064
122* KDM2B_26808549_Chip-Seq_K562_Human1.01637099
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01548349
124NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01399839
125RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00676716
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.99607762
127KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98175384
128ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96433581
129SOX2_20726797_ChIP-Seq_SW620_Human0.96280200
130SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95626496
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90258731
132AHR_22903824_ChIP-Seq_MCF-7_Human0.90106431

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.54905029
2* MP0004272_abnormal_basement_membrane5.31844552
3MP0003705_abnormal_hypodermis_morpholog3.96530937
4MP0005275_abnormal_skin_tensile3.51668244
5MP0009384_cardiac_valve_regurgitation2.63263277
6MP0005503_abnormal_tendon_morphology2.59938061
7MP0003279_aneurysm2.32719736
8MP0003566_abnormal_cell_adhesion2.26646018
9MP0003567_abnormal_fetal_cardiomyocyte2.26009694
10MP0001958_emphysema2.14258034
11MP0004084_abnormal_cardiac_muscle2.13629449
12MP0003941_abnormal_skin_development2.08148500
13MP0003828_pulmonary_edema2.03336003
14MP0010352_gastrointestinal_tract_polyps1.91013872
15MP0000751_myopathy1.86646368
16MP0006054_spinal_hemorrhage1.86153216
17* MP0005623_abnormal_meninges_morphology1.78466318
18MP0003119_abnormal_digestive_system1.77785457
19MP0010368_abnormal_lymphatic_system1.71616834
20MP0006138_congestive_heart_failure1.70313840
21MP0005076_abnormal_cell_differentiation1.61579645
22MP0003283_abnormal_digestive_organ1.59394972
23MP0003115_abnormal_respiratory_system1.58532920
24MP0001299_abnormal_eye_distance/1.54823522
25MP0000013_abnormal_adipose_tissue1.52771488
26MP0000537_abnormal_urethra_morphology1.47644631
27MP0000733_abnormal_muscle_development1.47288641
28MP0009780_abnormal_chondrocyte_physiolo1.47083385
29MP0010630_abnormal_cardiac_muscle1.43725107
30MP0002295_abnormal_pulmonary_circulatio1.42760572
31MP0005508_abnormal_skeleton_morphology1.41432329
32MP0004957_abnormal_blastocyst_morpholog1.41191149
33MP0002697_abnormal_eye_size1.40565560
34MP0003091_abnormal_cell_migration1.40112960
35MP0003984_embryonic_growth_retardation1.39575473
36MP0004087_abnormal_muscle_fiber1.39487556
37MP0000750_abnormal_muscle_regeneration1.38840485
38* MP0004197_abnormal_fetal_growth/weight/1.38247201
39MP0002088_abnormal_embryonic_growth/wei1.38057030
40* MP0002086_abnormal_extraembryonic_tissu1.37752325
41* MP0002084_abnormal_developmental_patter1.37664717
42MP0000767_abnormal_smooth_muscle1.37429151
43MP0005380_embryogenesis_phenotype1.32969216
44MP0001672_abnormal_embryogenesis/_devel1.32969216
45MP0001542_abnormal_bone_strength1.31853830
46MP0005023_abnormal_wound_healing1.27300194
47MP0000762_abnormal_tongue_morphology1.24294142
48MP0002837_dystrophic_cardiac_calcinosis1.23729220
49MP0002108_abnormal_muscle_morphology1.22748162
50MP0003385_abnormal_body_wall1.21899598
51MP0010234_abnormal_vibrissa_follicle1.21662637
52MP0002925_abnormal_cardiovascular_devel1.21125143
53MP0010030_abnormal_orbit_morphology1.19807563
54MP0005330_cardiomyopathy1.19191990
55MP0002060_abnormal_skin_morphology1.17650323
56MP0008775_abnormal_heart_ventricle1.15688571
57* MP0001915_intracranial_hemorrhage1.15681549
58MP0005595_abnormal_vascular_smooth1.14860447
59MP0009053_abnormal_anal_canal1.14848348
60MP0001243_abnormal_dermal_layer1.14379512
61MP0001730_embryonic_growth_arrest1.13726975
62MP0005385_cardiovascular_system_phenoty1.12196711
63MP0001544_abnormal_cardiovascular_syste1.12196711
64MP0001697_abnormal_embryo_size1.11709035
65MP0004233_abnormal_muscle_weight1.10247574
66MP0002127_abnormal_cardiovascular_syste1.09753054
67MP0003950_abnormal_plasma_membrane1.09042674
68MP0001849_ear_inflammation1.08711781
69* MP0002085_abnormal_embryonic_tissue1.06394920
70MP0003123_paternal_imprinting1.05763598
71MP0002896_abnormal_bone_mineralization1.05561291
72MP0005409_darkened_coat_color1.05433692
73MP0000428_abnormal_craniofacial_morphol1.05337494
74MP0003935_abnormal_craniofacial_develop1.05025507
75MP0002128_abnormal_blood_circulation1.03593897
76MP0000749_muscle_degeneration1.03231803
77MP0001614_abnormal_blood_vessel1.02769204
78MP0004185_abnormal_adipocyte_glucose1.02174971
79MP0000266_abnormal_heart_morphology1.00953544
80MP0004036_abnormal_muscle_relaxation0.99526172
81MP0001661_extended_life_span0.97912454
82MP0002106_abnormal_muscle_physiology0.97501987
83MP0002877_abnormal_melanocyte_morpholog0.96843604
84MP0005197_abnormal_uvea_morphology0.96693725
85MP0001879_abnormal_lymphatic_vessel0.96566345
86MP0004215_abnormal_myocardial_fiber0.95883060
87MP0005171_absent_coat_pigmentation0.94151840
88MP0001348_abnormal_lacrimal_gland0.93835529
89MP0000462_abnormal_digestive_system0.92400354
90MP0002972_abnormal_cardiac_muscle0.91281974
91MP0005369_muscle_phenotype0.90938267
92MP0002111_abnormal_tail_morphology0.90316390
93MP0009250_abnormal_appendicular_skeleto0.90273217
94MP0003221_abnormal_cardiomyocyte_apopto0.90124148
95MP0004133_heterotaxia0.89853642
96MP0003755_abnormal_palate_morphology0.88098489
97MP0000432_abnormal_head_morphology0.87869295
98MP0002282_abnormal_trachea_morphology0.87634214
99MP0005367_renal/urinary_system_phenotyp0.86683411
100MP0000516_abnormal_urinary_system0.86683411
101* MP0002269_muscular_atrophy0.84963530
102MP0000003_abnormal_adipose_tissue0.84883893
103MP0001293_anophthalmia0.83693619
104MP0002089_abnormal_postnatal_growth/wei0.83593041
105MP0000759_abnormal_skeletal_muscle0.83291673
106MP0009672_abnormal_birth_weight0.83223753
107MP0005666_abnormal_adipose_tissue0.83095584
108* MP0003942_abnormal_urinary_system0.82381407
109MP0000163_abnormal_cartilage_morphology0.81376814
110* MP0002080_prenatal_lethality0.81043611
111MP0002932_abnormal_joint_morphology0.80763432
112MP0005375_adipose_tissue_phenotype0.80608828
113MP0003045_fibrosis0.80604666
114MP0003937_abnormal_limbs/digits/tail_de0.80401660
115MP0005257_abnormal_intraocular_pressure0.80394042
116MP0000747_muscle_weakness0.80313736
117MP0003300_gastrointestinal_ulcer0.79937874
118* MP0000534_abnormal_ureter_morphology0.79532496
119MP0000467_abnormal_esophagus_morphology0.77098999
120MP0004134_abnormal_chest_morphology0.76470248
121MP0000049_abnormal_middle_ear0.75769230
122MP0002115_abnormal_skeleton_extremities0.72475256
123MP0005193_abnormal_anterior_eye0.71825426
124MP0005165_increased_susceptibility_to0.70540352
125MP0002113_abnormal_skeleton_development0.70331624
126MP0005390_skeleton_phenotype0.66781717
127MP0002114_abnormal_axial_skeleton0.66659265
128MP0002116_abnormal_craniofacial_bone0.65930241
129MP0002092_abnormal_eye_morphology0.65073853
130MP0002133_abnormal_respiratory_system0.64390192
131MP0005388_respiratory_system_phenotype0.64390192
132MP0002168_other_aberrant_phenotype0.63987318
133* MP0001175_abnormal_lung_morphology0.61812268
134MP0003448_altered_tumor_morphology0.61280352
135MP0005620_abnormal_muscle_contractility0.59586527

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.61158302
2Cerebral aneurysm (HP:0004944)5.42730379
3Premature rupture of membranes (HP:0001788)5.29114610
4Shallow orbits (HP:0000586)4.53926966
5Vascular tortuosity (HP:0004948)4.27466035
6Ankle contracture (HP:0006466)4.17665143
7Arterial tortuosity (HP:0005116)4.05087360
8Increased connective tissue (HP:0009025)3.35466373
9Broad metatarsal (HP:0001783)3.27398831
10Aortic dissection (HP:0002647)3.07560416
11Atrophic scars (HP:0001075)3.01132471
12Vertebral compression fractures (HP:0002953)2.92103387
13Wrist flexion contracture (HP:0001239)2.82203717
14Bladder diverticulum (HP:0000015)2.79695619
15Cervical subluxation (HP:0003308)2.78785603
16Type 1 muscle fiber predominance (HP:0003803)2.76957145
17Spinal rigidity (HP:0003306)2.73116071
18Aneurysm (HP:0002617)2.69450817
19Spondylolisthesis (HP:0003302)2.66814990
20Wormian bones (HP:0002645)2.64951773
21Muscle fiber splitting (HP:0003555)2.64415363
22Cerebellar dysplasia (HP:0007033)2.61517415
23Soft skin (HP:0000977)2.60066610
24Peritonitis (HP:0002586)2.58794963
25Right ventricular cardiomyopathy (HP:0011663)2.57178579
26Mitral valve prolapse (HP:0001634)2.53695336
27Fragile skin (HP:0001030)2.50805910
28Lymphangioma (HP:0100764)2.47690986
29Aortic aneurysm (HP:0004942)2.47518198
30Biconcave vertebral bodies (HP:0004586)2.46572606
31Hypoplasia of the iris (HP:0007676)2.45014361
32Abnormal delivery (HP:0001787)2.43127057
33Abnormality of the acetabulum (HP:0003170)2.42325754
34Blue sclerae (HP:0000592)2.41362264
35Slender build (HP:0001533)2.38045513
36Mitral regurgitation (HP:0001653)2.35227550
37Exercise-induced muscle cramps (HP:0003710)2.33693781
38Mitral stenosis (HP:0001718)2.32979782
39Disproportionate tall stature (HP:0001519)2.32294286
40Dilatation of the ascending aorta (HP:0005111)2.32202705
41Hyporeflexia of lower limbs (HP:0002600)2.28465857
42Knee flexion contracture (HP:0006380)2.28164984
43Missing ribs (HP:0000921)2.27761253
44Short 4th metacarpal (HP:0010044)2.26760129
45Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.26760129
46Short nail (HP:0001799)2.26111845
47Aortic regurgitation (HP:0001659)2.24417763
48Retinal atrophy (HP:0001105)2.22119668
49Coronal craniosynostosis (HP:0004440)2.21545494
50Hip contracture (HP:0003273)2.20926549
51Mildly elevated creatine phosphokinase (HP:0008180)2.20702162
52Deviation of the thumb (HP:0009603)2.20441612
53Genu recurvatum (HP:0002816)2.17498128
54Syringomyelia (HP:0003396)2.15316692
55Spinal cord lesions (HP:0100561)2.15316692
56Abnormality of dentin (HP:0010299)2.14417696
57Abnormal vertebral ossification (HP:0100569)2.13504899
58Ectopia lentis (HP:0001083)2.11444455
59Increased variability in muscle fiber diameter (HP:0003557)2.07684321
60Preaxial foot polydactyly (HP:0001841)2.07587436
61Abnormality of proline metabolism (HP:0010907)2.06900989
62Hydroxyprolinuria (HP:0003080)2.06900989
63Rectal prolapse (HP:0002035)2.04368718
64Ventricular tachycardia (HP:0004756)2.03369998
65Natal tooth (HP:0000695)2.01845057
66Cardiovascular calcification (HP:0011915)2.01385370
67Abnormality of the 4th metacarpal (HP:0010012)2.00932392
68Thin bony cortex (HP:0002753)1.99455756
69Short humerus (HP:0005792)1.98048629
70Follicular hyperkeratosis (HP:0007502)1.97843636
71Joint laxity (HP:0001388)1.96342717
72Sudden death (HP:0001699)1.95683472
73Aortic valve stenosis (HP:0001650)1.95451912
74Elbow flexion contracture (HP:0002987)1.95090030
75Proximal placement of thumb (HP:0009623)1.94705559
76Fused cervical vertebrae (HP:0002949)1.94537744
77Hyperextensible skin (HP:0000974)1.93527032
78Ulnar bowing (HP:0003031)1.92480158
79Breech presentation (HP:0001623)1.91231421
80High pitched voice (HP:0001620)1.87850000
81Abnormality of carpal bone ossification (HP:0006257)1.86419215
82Abnormality of the 1st metacarpal (HP:0010009)1.85240418
83Lipoatrophy (HP:0100578)1.84988030
84Renal duplication (HP:0000075)1.84530344
85Hemiplegia (HP:0002301)1.83908791
86Abnormality of skeletal muscle fiber size (HP:0012084)1.83210043
87Short hallux (HP:0010109)1.83004952
88Transposition of the great arteries (HP:0001669)1.82901802
89Abnormal connection of the cardiac segments (HP:0011545)1.82901802
90Abnormal ventriculo-arterial connection (HP:0011563)1.82901802
91Hypoventilation (HP:0002791)1.82724533
92Hyperacusis (HP:0010780)1.82398684
93Bowel diverticulosis (HP:0005222)1.82276481
94Skull defect (HP:0001362)1.82198978
95Abnormal ossification of hand bones (HP:0005921)1.81995014
96Inguinal hernia (HP:0000023)1.81653743
97Round ear (HP:0100830)1.81651473
98Coxa vara (HP:0002812)1.80769289
99Radial bowing (HP:0002986)1.79844358
100Pterygium (HP:0001059)1.79695011
101Patent foramen ovale (HP:0001655)1.79568068
102Amblyopia (HP:0000646)1.78642327
103Difficulty climbing stairs (HP:0003551)1.78551639
104Absent frontal sinuses (HP:0002688)1.78288580
105Overgrowth (HP:0001548)1.78227609
106Wide anterior fontanel (HP:0000260)1.78213760
107Osteoarthritis (HP:0002758)1.78126989
108Short phalanx of the thumb (HP:0009660)1.77908970
109Protruding ear (HP:0000411)1.77879509
110Delayed cranial suture closure (HP:0000270)1.77156325
111Distal upper limb amyotrophy (HP:0007149)1.76962503
112Upper limb amyotrophy (HP:0009129)1.76962503
113Aplasia/hypoplasia of the humerus (HP:0006507)1.76846269
114Cupped ribs (HP:0000887)1.75862134
115Aplasia/Hypoplasia of the hallux (HP:0008362)1.73302262
116Enlarged penis (HP:0000040)1.73059255
117Short 1st metacarpal (HP:0010034)1.71446047
118Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.71446047
119Striae distensae (HP:0001065)1.71364960
120Bell-shaped thorax (HP:0001591)1.71337452
121Osteolytic defects of the phalanges of the hand (HP:0009771)1.71151710
122Osteolytic defects of the hand bones (HP:0009699)1.71151710
123Limited hip movement (HP:0008800)1.70743494
124Hypoplastic ischia (HP:0003175)1.70034072
125Preauricular pit (HP:0004467)1.70002880
126Periauricular skin pits (HP:0100277)1.70002880
127Generalized amyotrophy (HP:0003700)1.69828663
128Deviation of the hallux (HP:0010051)1.68809693
129Broad ribs (HP:0000885)1.68285904
130Difficulty running (HP:0009046)1.66900763
131Neonatal short-limb short stature (HP:0008921)1.66743454
132Metaphyseal cupping (HP:0003021)1.66622559
133Arachnodactyly (HP:0001166)1.66325233
134Camptodactyly of toe (HP:0001836)1.65967666
135Joint stiffness (HP:0001387)1.65955518
136Vertebral arch anomaly (HP:0008438)1.65432179
137Persistence of primary teeth (HP:0006335)1.65250819
138Bowing of the arm (HP:0006488)1.64635973
139Bowed forearm bones (HP:0003956)1.64635973
140Mild short stature (HP:0003502)1.64538834
141Occipital encephalocele (HP:0002085)1.64381640
142Flexion contracture of toe (HP:0005830)1.64204019
143Joint contractures involving the joints of the feet (HP:0100492)1.64204019
144Nonimmune hydrops fetalis (HP:0001790)1.63984584
145Hallux valgus (HP:0001822)1.63162610
146Broad long bones (HP:0005622)1.63073372
147Broad face (HP:0000283)1.62966506
148Achilles tendon contracture (HP:0001771)1.62655530
149Arnold-Chiari malformation (HP:0002308)1.62451495
150Delayed closure of the anterior fontanelle (HP:0001476)1.61927713
151Flat cornea (HP:0007720)1.60809725
152Abnormality of the calcaneus (HP:0008364)1.60688573
153Ovoid vertebral bodies (HP:0003300)1.59550998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.55737417
2TTN3.49441508
3PKN23.43785444
4CDK123.08013390
5LATS13.02214693
6PDGFRA3.00730991
7NTRK12.73021542
8LATS22.65091431
9DDR22.52451122
10EPHA22.30439890
11RIPK12.10548632
12DMPK2.07659521
13TIE12.01302323
14EEF2K1.71663876
15PTK61.64496986
16SIK11.64304332
17MAP3K101.62562641
18TGFBR11.61174620
19SCYL21.57404013
20ERBB41.56327594
21PAK41.54173276
22MTOR1.52288107
23MST1R1.49101091
24CDK41.48225846
25FER1.48065450
26AKT31.47306910
27EPHB21.46004651
28NEK11.44018206
29MET1.41332009
30TYRO31.40389534
31SMG11.39407370
32STK31.32373049
33PTK21.29770476
34PAK21.24130476
35RPS6KB21.23993680
36FGFR11.23867106
37ICK1.23646663
38FGFR41.22093427
39MOS1.20256128
40PRKD21.19128424
41TGFBR21.17879072
42BMX1.17270698
43NEK21.15737715
44CAMK1D1.14190043
45KDR1.12771692
46PDGFRB1.05426227
47LRRK21.04943120
48LMTK21.01564401
49STK38L0.98598736
50ERN10.96338487
51ILK0.95242040
52PRKD30.93684813
53CDK60.93230033
54STK100.90652694
55MAP3K80.90301058
56PDK40.85191007
57PDK30.85191007
58RPS6KA20.84294721
59BRD40.80211362
60PIK3CG0.79288790
61TTK0.78670008
62RPS6KA40.78453950
63PRKD10.77913761
64MAP3K60.75630381
65PAK30.73951472
66FLT30.73486834
67WEE10.71490129
68IRAK30.70010069
69TRPM70.69694430
70CDK70.69520953
71ALK0.69318791
72CAMK1G0.69147496
73CDC70.67885740
74PDK20.67826274
75ROCK10.67672035
76PRKG20.66870209
77ABL20.66791260
78MYLK0.66189460
79PTK2B0.65940568
80EPHB10.62868839
81FGFR20.60790990
82NEK90.60216818
83WNK10.60097338
84RET0.59850480
85CDC42BPA0.59100271
86PASK0.58553615
87CDK80.55659560
88ROCK20.55300186
89AKT20.54183035
90MAP2K30.51936107
91MELK0.51512605
92GSK3A0.51029397
93MAP3K30.50653342
94OBSCN0.50491880
95MAPKAPK30.49826436
96AURKB0.47141697
97STK40.47078316
98FGFR30.46922576
99ACVR1B0.46620273
100MAP2K10.46224186
101MAPK10.44190023
102DAPK30.42667097
103PAK10.42446449
104ARAF0.42403363
105INSR0.41958800
106TESK10.41932981
107PNCK0.41804602
108CLK10.41317824
109MAPK70.39752427
110* CHEK10.38755425
111CDK90.37216325
112LIMK10.36323717
113PLK10.36217128
114PLK30.34936575
115PAK60.34051821
116KSR20.33483354
117CHUK0.33469991
118STK240.33101493
119MAP3K70.32269173
120STK380.32164959
121PIM20.31835329
122ERBB20.31576917
123CSNK1D0.31567495
124SRC0.30965330
125MARK20.30690215
126MUSK0.27975442
127RPS6KC10.27839070
128RPS6KL10.27839070
129CAMK2G0.22123858

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045124.36019657
2* Small cell lung cancer_Homo sapiens_hsa052223.27896271
3* Focal adhesion_Homo sapiens_hsa045102.96166791
4* Amoebiasis_Homo sapiens_hsa051462.61892534
5Adherens junction_Homo sapiens_hsa045202.42840219
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.24939408
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.18909881
8Dilated cardiomyopathy_Homo sapiens_hsa054142.15192337
9Hippo signaling pathway_Homo sapiens_hsa043902.11818968
10Proteoglycans in cancer_Homo sapiens_hsa052052.03254899
11Protein digestion and absorption_Homo sapiens_hsa049741.94420520
12Basal cell carcinoma_Homo sapiens_hsa052171.85339741
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.74145012
14Viral myocarditis_Homo sapiens_hsa054161.70167422
15Tight junction_Homo sapiens_hsa045301.69885639
16Lysine degradation_Homo sapiens_hsa003101.69013819
17TGF-beta signaling pathway_Homo sapiens_hsa043501.65914378
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.63781722
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.63446012
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.63247721
21Hedgehog signaling pathway_Homo sapiens_hsa043401.63062507
22MicroRNAs in cancer_Homo sapiens_hsa052061.62803130
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60835198
24* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.60558883
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59007618
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.45978753
27* Toxoplasmosis_Homo sapiens_hsa051451.43460609
28Bladder cancer_Homo sapiens_hsa052191.42417375
29* Pathways in cancer_Homo sapiens_hsa052001.41029169
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39371385
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31385782
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24614009
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.21379844
34Notch signaling pathway_Homo sapiens_hsa043301.19627138
35Chronic myeloid leukemia_Homo sapiens_hsa052201.16847008
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11870183
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.11793591
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11779448
39mTOR signaling pathway_Homo sapiens_hsa041501.07264629
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06041531
41Insulin resistance_Homo sapiens_hsa049311.05173271
42Cell cycle_Homo sapiens_hsa041101.03133951
43p53 signaling pathway_Homo sapiens_hsa041151.02744833
44Wnt signaling pathway_Homo sapiens_hsa043101.01045809
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00606662
46Melanoma_Homo sapiens_hsa052180.99886098
47Other glycan degradation_Homo sapiens_hsa005110.98892604
48N-Glycan biosynthesis_Homo sapiens_hsa005100.98614448
49Prostate cancer_Homo sapiens_hsa052150.98591694
50HIF-1 signaling pathway_Homo sapiens_hsa040660.98511652
51Complement and coagulation cascades_Homo sapiens_hsa046100.97425077
52Rap1 signaling pathway_Homo sapiens_hsa040150.97274417
53AMPK signaling pathway_Homo sapiens_hsa041520.96726459
54HTLV-I infection_Homo sapiens_hsa051660.93942979
55Thyroid cancer_Homo sapiens_hsa052160.92693712
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92628526
57RNA transport_Homo sapiens_hsa030130.92001551
58Renal cell carcinoma_Homo sapiens_hsa052110.88965431
59Endometrial cancer_Homo sapiens_hsa052130.87647985
60Colorectal cancer_Homo sapiens_hsa052100.86168254
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83895924
62Viral carcinogenesis_Homo sapiens_hsa052030.80480003
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80262330
64Nitrogen metabolism_Homo sapiens_hsa009100.79851094
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79787916
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79692303
67Carbon metabolism_Homo sapiens_hsa012000.77835536
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77558055
69Melanogenesis_Homo sapiens_hsa049160.76155704
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75405467
71Insulin signaling pathway_Homo sapiens_hsa049100.73225374
72One carbon pool by folate_Homo sapiens_hsa006700.73135219
73Malaria_Homo sapiens_hsa051440.72835861
74Renin-angiotensin system_Homo sapiens_hsa046140.72110066
75Pancreatic cancer_Homo sapiens_hsa052120.70881581
76Galactose metabolism_Homo sapiens_hsa000520.70225472
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69766397
78Glioma_Homo sapiens_hsa052140.68643613
79Vibrio cholerae infection_Homo sapiens_hsa051100.68191278
80Estrogen signaling pathway_Homo sapiens_hsa049150.67755919
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67408489
82Platelet activation_Homo sapiens_hsa046110.65695084
83Axon guidance_Homo sapiens_hsa043600.64653141
84Dorso-ventral axis formation_Homo sapiens_hsa043200.63849472
85* Prion diseases_Homo sapiens_hsa050200.62708536
86Glucagon signaling pathway_Homo sapiens_hsa049220.62182448
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.62142818
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61397368
89Biosynthesis of amino acids_Homo sapiens_hsa012300.61006031
90Pentose phosphate pathway_Homo sapiens_hsa000300.58719666
91VEGF signaling pathway_Homo sapiens_hsa043700.57181330
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56747039
93mRNA surveillance pathway_Homo sapiens_hsa030150.56308128
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.55036677
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54493876
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.53098277
97FoxO signaling pathway_Homo sapiens_hsa040680.50327127
98GnRH signaling pathway_Homo sapiens_hsa049120.49333548
99Oocyte meiosis_Homo sapiens_hsa041140.48976423
100Choline metabolism in cancer_Homo sapiens_hsa052310.47192915
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44209268
102Endocytosis_Homo sapiens_hsa041440.44104110
103Sphingolipid metabolism_Homo sapiens_hsa006000.43232581
104Thyroid hormone synthesis_Homo sapiens_hsa049180.41703839
105Gap junction_Homo sapiens_hsa045400.41565815
106Non-small cell lung cancer_Homo sapiens_hsa052230.40402632
107Apoptosis_Homo sapiens_hsa042100.40324704
108Shigellosis_Homo sapiens_hsa051310.39889614
109Salmonella infection_Homo sapiens_hsa051320.37123156
110Ras signaling pathway_Homo sapiens_hsa040140.37008955
111Acute myeloid leukemia_Homo sapiens_hsa052210.36875190
112Hepatitis B_Homo sapiens_hsa051610.36788263
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.36733000
114MAPK signaling pathway_Homo sapiens_hsa040100.35908529
115Inositol phosphate metabolism_Homo sapiens_hsa005620.34655106
116ErbB signaling pathway_Homo sapiens_hsa040120.34578908
117Prolactin signaling pathway_Homo sapiens_hsa049170.34200183
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33932779
119Type II diabetes mellitus_Homo sapiens_hsa049300.33794944
120Arginine and proline metabolism_Homo sapiens_hsa003300.33006863
121Sulfur metabolism_Homo sapiens_hsa009200.31155248

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