LAMC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.47543942
2bundle of His cell to Purkinje myocyte communication (GO:0086069)6.62927645
3regulation of keratinocyte proliferation (GO:0010837)6.50818799
4regulation of hair follicle development (GO:0051797)5.88176827
5mesodermal cell differentiation (GO:0048333)5.49745637
6* cell-substrate junction assembly (GO:0007044)5.30054091
7regulation of water loss via skin (GO:0033561)5.28247650
8interferon-gamma secretion (GO:0072643)5.03121922
9positive regulation of hair cycle (GO:0042635)4.73868239
10positive regulation of hair follicle development (GO:0051798)4.73868239
11surfactant homeostasis (GO:0043129)4.61916751
12establishment of skin barrier (GO:0061436)4.48688472
13positive regulation of epidermis development (GO:0045684)4.46073266
14cell adhesion mediated by integrin (GO:0033627)4.45727348
15gap junction assembly (GO:0016264)4.40532578
16regulation of hair cycle (GO:0042634)4.15457911
17multicellular organismal water homeostasis (GO:0050891)4.14806314
18skin morphogenesis (GO:0043589)4.11764628
19positive regulation of epidermal cell differentiation (GO:0045606)4.11567799
20negative regulation of cell fate specification (GO:0009996)4.08923813
21negative regulation of keratinocyte proliferation (GO:0010839)4.06190580
22keratinization (GO:0031424)4.04435766
23regulation of hippo signaling (GO:0035330)4.04344079
24epithelial cell-cell adhesion (GO:0090136)4.02740564
25protein localization to endosome (GO:0036010)4.01007692
26lung lobe morphogenesis (GO:0060463)3.96464167
27keratinocyte differentiation (GO:0030216)3.93488313
28intestinal epithelial cell development (GO:0060576)3.89150894
29lateral sprouting from an epithelium (GO:0060601)3.87874839
30odontogenesis of dentin-containing tooth (GO:0042475)3.84116842
31negative regulation of epidermis development (GO:0045683)3.81021401
32hair cycle (GO:0042633)3.80440768
33molting cycle (GO:0042303)3.80440768
34renal system development (GO:0072001)3.79158549
35gland morphogenesis (GO:0022612)3.78906203
36endodermal cell differentiation (GO:0035987)3.74339172
37cytoskeletal anchoring at plasma membrane (GO:0007016)3.68662204
38tight junction assembly (GO:0070830)3.67914769
39regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.64043369
40hepatocyte apoptotic process (GO:0097284)3.63745146
41chemical homeostasis within a tissue (GO:0048875)3.61683143
42odontogenesis (GO:0042476)3.60994922
43ectoderm development (GO:0007398)3.60066095
44regulation of cell fate specification (GO:0042659)3.55391153
45regulation of epidermis development (GO:0045682)3.51040464
46mammary gland development (GO:0030879)3.50698008
47branching involved in salivary gland morphogenesis (GO:0060445)3.49893924
48dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.48122189
49peptidyl-tyrosine autophosphorylation (GO:0038083)3.47598934
50atrioventricular valve morphogenesis (GO:0003181)3.45055619
51keratinocyte development (GO:0003334)3.40311938
52water homeostasis (GO:0030104)3.40121422
53regulation of glomerular filtration (GO:0003093)3.37267726
54hypotonic response (GO:0006971)3.34853837
55tooth mineralization (GO:0034505)3.34164300
56lung-associated mesenchyme development (GO:0060484)3.32458190
57regulation of cardioblast differentiation (GO:0051890)3.32415594
58L-serine transport (GO:0015825)3.32209350
59renal filtration (GO:0097205)3.30576679
60wound healing, spreading of epidermal cells (GO:0035313)3.29172138
61lung vasculature development (GO:0060426)3.27163787
62positive regulation of positive chemotaxis (GO:0050927)3.24068361
63keratinocyte proliferation (GO:0043616)3.23652236
64cellular response to vitamin D (GO:0071305)3.20633994
65cellular copper ion homeostasis (GO:0006878)3.20350251
66establishment of apical/basal cell polarity (GO:0035089)3.19870878
67glial cell proliferation (GO:0014009)3.18731470
68* epidermis development (GO:0008544)3.18153714
69intermediate filament cytoskeleton organization (GO:0045104)3.18086724
70positive regulation of actin filament depolymerization (GO:0030836)3.16273628
71epithelial cell differentiation involved in prostate gland development (GO:0060742)3.14707860
72regulation of transforming growth factor beta2 production (GO:0032909)3.14460877
73regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.11942497
74epidermal cell differentiation (GO:0009913)3.10656937
75hippo signaling (GO:0035329)3.10353348
76diterpenoid biosynthetic process (GO:0016102)3.09170591
77positive regulation of keratinocyte differentiation (GO:0045618)3.08843559
78* cell junction assembly (GO:0034329)3.08607950
79cardiac right ventricle morphogenesis (GO:0003215)3.07886434
80positive regulation of odontogenesis (GO:0042482)3.07076612
81regulation of positive chemotaxis (GO:0050926)3.06774334
82intermediate filament-based process (GO:0045103)3.06537166
83regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.06299389
84regulation of transforming growth factor beta production (GO:0071634)3.05798135
85polarized epithelial cell differentiation (GO:0030859)3.05048558
86cell-substrate adherens junction assembly (GO:0007045)3.04084459
87focal adhesion assembly (GO:0048041)3.04084459
88wound healing (GO:0042060)2.99820574
89* cell junction organization (GO:0034330)2.99564431
90membrane budding (GO:0006900)2.98913330
91heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.98625092
92negative regulation of cell fate commitment (GO:0010454)2.97960464
93wound healing, spreading of cells (GO:0044319)2.97842036
94regulation of chemokine secretion (GO:0090196)2.95980412
95negative regulation of cartilage development (GO:0061037)2.95094164
96pattern specification involved in kidney development (GO:0061004)2.94564371
97substrate-dependent cell migration (GO:0006929)2.94371904
98regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.93142672
99positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.93142672
100virion attachment to host cell (GO:0019062)2.92252760
101adhesion of symbiont to host cell (GO:0044650)2.92252760
102regulation of keratinocyte differentiation (GO:0045616)2.91503625
103renal system process involved in regulation of blood volume (GO:0001977)2.91412718
104positive regulation of osteoblast proliferation (GO:0033690)2.90463029
105intermediate filament organization (GO:0045109)2.88306228
106cell-cell junction assembly (GO:0007043)2.85928604
107neural crest cell development (GO:0014032)2.85659642
108embryonic foregut morphogenesis (GO:0048617)2.83901113
109serine transport (GO:0032329)2.82464698
110regulation of metalloenzyme activity (GO:0048552)2.80553786
111morphogenesis of embryonic epithelium (GO:0016331)2.80195954
112adherens junction organization (GO:0034332)2.78193218
113establishment of epithelial cell polarity (GO:0090162)2.78008785
114branching involved in mammary gland duct morphogenesis (GO:0060444)2.77373667
115mammary gland epithelial cell proliferation (GO:0033598)2.77282026
116regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.76517938
117hepatocyte differentiation (GO:0070365)2.75383444
118membrane raft organization (GO:0031579)2.75037133
119positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.74826968
120regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.72577717
121ventricular cardiac muscle cell action potential (GO:0086005)2.71708670
122calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.70560464
123cellular response to vitamin (GO:0071295)2.69958038
124planar cell polarity pathway involved in neural tube closure (GO:0090179)2.68509613
125regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.68126690
126mammary gland alveolus development (GO:0060749)2.66695448
127skin development (GO:0043588)2.66221974
128cell surface receptor signaling pathway involved in heart development (GO:0061311)2.66131303
129trophectodermal cell differentiation (GO:0001829)2.65124734
130epithelial tube branching involved in lung morphogenesis (GO:0060441)2.65031144
131positive regulation of p38MAPK cascade (GO:1900745)2.64977352
132establishment or maintenance of monopolar cell polarity (GO:0061339)2.62078222
133establishment of monopolar cell polarity (GO:0061162)2.62078222
134* extracellular matrix disassembly (GO:0022617)2.61954014
135adherens junction assembly (GO:0034333)2.59786073
136semaphorin-plexin signaling pathway (GO:0071526)2.59766382
137positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.59276192
138epithelial structure maintenance (GO:0010669)2.58831803
139cell communication involved in cardiac conduction (GO:0086065)2.58410262
140peptide cross-linking (GO:0018149)2.57130486
141positive regulation of protein localization to plasma membrane (GO:1903078)2.56996981
142filopodium assembly (GO:0046847)2.56318107
143positive regulation of endothelial cell apoptotic process (GO:2000353)2.55768987
144regulation of transforming growth factor beta1 production (GO:0032908)2.54714772
145negative regulation of anoikis (GO:2000811)2.54342777
146establishment of planar polarity (GO:0001736)2.53745543
147establishment of tissue polarity (GO:0007164)2.53745543
148regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53214261
149regulation of phospholipase A2 activity (GO:0032429)2.52943261
150regulation of heart rate by cardiac conduction (GO:0086091)2.52933800
151positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.52840381
152negative regulation of chondrocyte differentiation (GO:0032331)2.51650617
153* hemidesmosome assembly (GO:0031581)13.9305880

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.83300469
2* SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.92974915
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.46499274
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.08653176
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.88330072
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.69345072
7ZNF263_19887448_ChIP-Seq_K562_Human2.68203306
8* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.50448559
9* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.50448559
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35621651
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.29790786
12SOX9_24532713_ChIP-Seq_HFSC_Mouse2.23687504
13FOXO3_23340844_ChIP-Seq_DLD1_Human2.05994636
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.03450747
15KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.02831951
16CLOCK_20551151_ChIP-Seq_293T_Human2.02325404
17SOX2_20726797_ChIP-Seq_SW620_Human2.00527999
18TP63_17297297_ChIP-ChIP_HaCaT_Human12.4995522
19CDX2_20551321_ChIP-Seq_CACO-2_Human1.99319441
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.96474683
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.96255923
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94556131
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92188444
24* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.90903351
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.86439990
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82143462
27P63_26484246_Chip-Seq_KERATINOCYTES_Human1.79884700
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77896388
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.70186681
30RACK7_27058665_Chip-Seq_MCF-7_Human1.64533923
31* RUNX1_27514584_Chip-Seq_MCF-7_Human1.62076585
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59713854
33* GATA4_25053715_ChIP-Seq_YYC3_Human1.59417820
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.58967423
35* GATA6_25053715_ChIP-Seq_YYC3_Human1.58111433
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57650497
37* KLF5_25053715_ChIP-Seq_YYC3_Human1.55783554
38* ATF3_27146783_Chip-Seq_COLON_Human1.55482370
39* CJUN_26792858_Chip-Seq_BT549_Human1.54988720
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46970784
41* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44749522
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41037379
43AHR_22903824_ChIP-Seq_MCF-7_Human1.36981554
44* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36697529
45* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.35725208
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34024788
47UBF1/2_26484160_Chip-Seq_HMECs_Human1.31302158
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29747142
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27912489
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.27912207
51GATA3_24758297_ChIP-Seq_MCF-7_Human1.26617564
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23665522
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21798444
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21606811
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18108242
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17804483
57EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16078935
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14560285
59AR_21909140_ChIP-Seq_LNCAP_Human1.14275243
60* TCF4_18268006_ChIP-ChIP_LS174T_Human1.13117219
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11855938
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.11488203
63* TP63_22573176_ChIP-Seq_HFKS_Human1.11483433
64JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11145834
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09903684
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.05487624
67* TP63_23658742_ChIP-Seq_EP156T_Human1.03837832
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.03384172
69ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02920619
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02524237
71ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99043413
72SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98651113
73SALL1_21062744_ChIP-ChIP_HESCs_Human0.96475419
74* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92930868
75* BRD4_25478319_ChIP-Seq_HGPS_Human0.92319413
76TP53_18474530_ChIP-ChIP_U2OS_Human0.90846426
77* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89939549
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89703543
79SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88948552
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88932855
81TBX20_22328084_ChIP-Seq_HEART_Mouse0.88339542
82TBX20_22080862_ChIP-Seq_HEART_Mouse0.88339542
83ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87662560
84FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87169097
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86486301
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85468430
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84668827
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84039030
89* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83857477
90CHD1_26751641_Chip-Seq_LNCaP_Human0.83034160
91* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.83011205
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82705679
93ISL1_27105846_Chip-Seq_CPCs_Mouse0.82542612
94* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82510638
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82073013
96KDM2B_26808549_Chip-Seq_K562_Human0.81564921
97TP53_22127205_ChIP-Seq_IMR90_Human0.81090948
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80800738
99GATA1_22025678_ChIP-Seq_K562_Human0.80117826
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78433496
101TP53_20018659_ChIP-ChIP_R1E_Mouse0.77178527
102SMAD_19615063_ChIP-ChIP_OVARY_Human0.76979727
103TP53_16413492_ChIP-PET_HCT116_Human0.76632025
104* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.76527691
105TCF3_18692474_ChIP-Seq_MESCs_Mouse0.76063820
106KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.76022659
107KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.76022659
108KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.76022659
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.75227292
110GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.72660523
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71427509
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.68365897
113EGR1_19032775_ChIP-ChIP_M12_Human0.66601872
114SRY_22984422_ChIP-ChIP_TESTIS_Rat0.65936934
115* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.65164154
116TET1_21490601_ChIP-Seq_MESCs_Mouse0.64191864
117ELK1_22589737_ChIP-Seq_MCF10A_Human0.60837076
118* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.60765219
119TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.58541028
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.55718714
121* TP53_23651856_ChIP-Seq_MEFs_Mouse0.55109685
122* ELK4_26923725_Chip-Seq_MESODERM_Mouse0.54150092
123ERG_21242973_ChIP-ChIP_JURKAT_Human0.54046033
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.51786300
125KLF4_18555785_ChIP-Seq_MESCs_Mouse0.49711577
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.46460316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.15902925
2MP0002254_reproductive_system_inflammat4.09677804
3MP0002796_impaired_skin_barrier3.62026953
4MP0010678_abnormal_skin_adnexa3.33238716
5MP0000537_abnormal_urethra_morphology3.20070686
6MP0005409_darkened_coat_color3.08841638
7MP0000579_abnormal_nail_morphology3.07416466
8MP0000383_abnormal_hair_follicle2.90461805
9MP0003566_abnormal_cell_adhesion2.88783373
10MP0002234_abnormal_pharynx_morphology2.87657558
11MP0003453_abnormal_keratinocyte_physiol2.76201508
12MP0003705_abnormal_hypodermis_morpholog2.70271426
13MP0000762_abnormal_tongue_morphology2.67489244
14MP0000467_abnormal_esophagus_morphology2.56788532
15MP0003941_abnormal_skin_development2.55710347
16MP0005501_abnormal_skin_physiology2.50346091
17MP0004264_abnormal_extraembryonic_tissu2.40521591
18MP0002098_abnormal_vibrissa_morphology2.34281164
19MP0000566_synostosis2.32710699
20* MP0002060_abnormal_skin_morphology2.29395153
21* MP0001216_abnormal_epidermal_layer2.27337799
22MP0010352_gastrointestinal_tract_polyps2.16067673
23MP0004782_abnormal_surfactant_physiolog2.07338366
24* MP0005275_abnormal_skin_tensile1.91914751
25* MP0001849_ear_inflammation1.87306196
26MP0005023_abnormal_wound_healing1.83847555
27MP0008260_abnormal_autophagy1.79171744
28MP0001346_abnormal_lacrimal_gland1.72293138
29MP0009053_abnormal_anal_canal1.71197724
30* MP0010771_integument_phenotype1.69964970
31MP0005360_urolithiasis1.68610016
32MP0006054_spinal_hemorrhage1.65700814
33MP0000377_abnormal_hair_follicle1.64874712
34* MP0004272_abnormal_basement_membrane1.64084006
35MP0001958_emphysema1.54403253
36MP0002877_abnormal_melanocyte_morpholog1.47803121
37MP0010030_abnormal_orbit_morphology1.42677620
38MP0000627_abnormal_mammary_gland1.40806287
39MP0008004_abnormal_stomach_pH1.36248447
40MP0003300_gastrointestinal_ulcer1.35661533
41MP0002282_abnormal_trachea_morphology1.31875991
42MP0004947_skin_inflammation1.29291225
43MP0003191_abnormal_cellular_cholesterol1.27569688
44MP0000647_abnormal_sebaceous_gland1.26217623
45MP0005367_renal/urinary_system_phenotyp1.19840773
46MP0000516_abnormal_urinary_system1.19840773
47MP0005257_abnormal_intraocular_pressure1.19516673
48MP0005248_abnormal_Harderian_gland1.17987228
49MP0005076_abnormal_cell_differentiation1.17727385
50MP0002138_abnormal_hepatobiliary_system1.16612348
51MP0000427_abnormal_hair_cycle1.14649087
52MP0003045_fibrosis1.09406604
53MP0009384_cardiac_valve_regurgitation1.08618210
54* MP0009931_abnormal_skin_appearance1.04147409
55MP0002896_abnormal_bone_mineralization1.02966257
56MP0000534_abnormal_ureter_morphology1.02844238
57* MP0000432_abnormal_head_morphology1.02741670
58MP0001191_abnormal_skin_condition1.02714712
59MP0009780_abnormal_chondrocyte_physiolo1.00805685
60MP0005623_abnormal_meninges_morphology0.99704798
61MP0000733_abnormal_muscle_development0.96114860
62MP0000470_abnormal_stomach_morphology0.95717494
63MP0003935_abnormal_craniofacial_develop0.95384275
64MP0002233_abnormal_nose_morphology0.95297426
65MP0001881_abnormal_mammary_gland0.95021977
66MP0003937_abnormal_limbs/digits/tail_de0.94892155
67MP0003755_abnormal_palate_morphology0.93470424
68MP0003115_abnormal_respiratory_system0.93183738
69MP0005499_abnormal_olfactory_system0.91725601
70MP0005394_taste/olfaction_phenotype0.91725601
71MP0001299_abnormal_eye_distance/0.91335336
72MP0004019_abnormal_vitamin_homeostasis0.91220922
73MP0000858_altered_metastatic_potential0.90139383
74MP0003329_amyloid_beta_deposits0.90050192
75MP0003091_abnormal_cell_migration0.89590165
76MP0000613_abnormal_salivary_gland0.89518838
77MP0004185_abnormal_adipocyte_glucose0.88280896
78MP0010155_abnormal_intestine_physiology0.85335902
79MP0003315_abnormal_perineum_morphology0.84261834
80MP0002089_abnormal_postnatal_growth/wei0.81133442
81MP0005197_abnormal_uvea_morphology0.77750779
82MP0000477_abnormal_intestine_morphology0.77674242
83MP0001851_eye_inflammation0.77170515
84MP0008789_abnormal_olfactory_epithelium0.75286935
85MP0008438_abnormal_cutaneous_collagen0.75151512
86MP0002111_abnormal_tail_morphology0.74030411
87MP0003942_abnormal_urinary_system0.73439629
88MP0001542_abnormal_bone_strength0.71529947
89MP0010368_abnormal_lymphatic_system0.71195100
90MP0003448_altered_tumor_morphology0.70327685
91MP0005508_abnormal_skeleton_morphology0.70020478
92MP0001879_abnormal_lymphatic_vessel0.69560685
93MP0003119_abnormal_digestive_system0.68283862
94MP0000678_abnormal_parathyroid_gland0.67936169
95MP0005164_abnormal_response_to0.66933853
96MP0001340_abnormal_eyelid_morphology0.65801442
97MP0002925_abnormal_cardiovascular_devel0.65536651
98MP0003936_abnormal_reproductive_system0.63488276
99MP0001243_abnormal_dermal_layer0.62453617
100MP0002697_abnormal_eye_size0.61698351
101MP0002295_abnormal_pulmonary_circulatio0.61560506
102MP0005193_abnormal_anterior_eye0.61236143
103MP0000367_abnormal_coat/_hair0.59581709
104MP0003866_abnormal_defecation0.59481931
105MP0003950_abnormal_plasma_membrane0.58640307
106MP0002133_abnormal_respiratory_system0.56686425
107MP0005388_respiratory_system_phenotype0.56686425
108MP0001784_abnormal_fluid_regulation0.56270632
109MP0006138_congestive_heart_failure0.56183452
110MP0004858_abnormal_nervous_system0.55734557
111MP0002909_abnormal_adrenal_gland0.55005529
112MP0002168_other_aberrant_phenotype0.54948913
113MP0003385_abnormal_body_wall0.54679517
114* MP0000163_abnormal_cartilage_morphology0.53619159
115MP0004381_abnormal_hair_follicle0.53176978
116MP0000428_abnormal_craniofacial_morphol0.52975822
117MP0008932_abnormal_embryonic_tissue0.51568834
118MP0005621_abnormal_cell_physiology0.50623519
119MP0004134_abnormal_chest_morphology0.49009200
120MP0000013_abnormal_adipose_tissue0.48200657
121MP0001765_abnormal_ion_homeostasis0.46519079
122MP0005451_abnormal_body_composition0.46051468
123MP0001915_intracranial_hemorrhage0.46043531
124MP0000003_abnormal_adipose_tissue0.44662274
125MP0001661_extended_life_span0.42189310
126MP0003786_premature_aging0.41519487
127MP0000750_abnormal_muscle_regeneration0.41319169
128MP0002006_tumorigenesis0.41082595
129MP0004885_abnormal_endolymph0.40716280
130MP0005165_increased_susceptibility_to0.40354730
131MP0005330_cardiomyopathy0.38820398

Predicted human phenotypes

RankGene SetZ-score
1* Onycholysis (HP:0001806)8.99110099
2* Milia (HP:0001056)8.95984940
3* Fragile nails (HP:0001808)7.54271566
4* Atrophic scars (HP:0001075)7.09668649
5Amelogenesis imperfecta (HP:0000705)6.90889938
6* Plantar hyperkeratosis (HP:0007556)6.01721884
7Right ventricular cardiomyopathy (HP:0011663)5.99827003
8Pili torti (HP:0003777)4.67525370
9* Nail dystrophy (HP:0008404)4.36850219
10Interstitial pulmonary disease (HP:0006530)4.22670424
11Thick nail (HP:0001805)4.12760176
12Woolly hair (HP:0002224)3.69591462
13* Hypoplasia of dental enamel (HP:0006297)3.59194303
14* Abnormal blistering of the skin (HP:0008066)3.53529430
15Esophageal atresia (HP:0002032)3.50415339
16Palmoplantar hyperkeratosis (HP:0000972)3.45101031
17Fragile skin (HP:0001030)3.41055770
18Abnormality of placental membranes (HP:0011409)3.39942510
19Amniotic constriction ring (HP:0009775)3.39942510
20Aplasia cutis congenita (HP:0001057)3.39288628
21Sparse scalp hair (HP:0002209)3.37194481
22Alopecia of scalp (HP:0002293)3.29958201
23Palmar hyperkeratosis (HP:0010765)3.25439982
24Sparse eyelashes (HP:0000653)3.12251716
25Ridged nail (HP:0001807)3.09360567
26Curly hair (HP:0002212)3.05223663
27Popliteal pterygium (HP:0009756)2.97983307
28Abnormality of oral frenula (HP:0000190)2.97213767
29Hypotrichosis (HP:0001006)2.89840184
30Pterygium (HP:0001059)2.81910007
31Abnormality of nail color (HP:0100643)2.80261416
32Dry hair (HP:0011359)2.77282268
33Abnormal hair laboratory examination (HP:0003328)2.69068336
34Ureteral stenosis (HP:0000071)2.63723103
35Oligodontia (HP:0000677)2.62002032
36Abnormality of the gastric mucosa (HP:0004295)2.60076938
37* Carious teeth (HP:0000670)2.59761669
38Bronchomalacia (HP:0002780)2.52740903
39Abnormality of the neuromuscular junction (HP:0003398)2.51976377
40Fatigable weakness (HP:0003473)2.51976377
41Absent eyelashes (HP:0000561)2.49349089
42Cheilitis (HP:0100825)2.47573940
43Ureteral obstruction (HP:0006000)2.43483270
44Oral leukoplakia (HP:0002745)2.42818019
45Neurofibrillary tangles (HP:0002185)2.37508910
46Abnormality of the axillary hair (HP:0100134)2.36831965
47Abnormality of secondary sexual hair (HP:0009888)2.36831965
48Xerostomia (HP:0000217)2.35410012
49Micronodular cirrhosis (HP:0001413)2.34757087
50Abnormality of the salivary glands (HP:0010286)2.33816245
51Anonychia (HP:0001798)2.27166659
52Shallow orbits (HP:0000586)2.27107540
53Blepharitis (HP:0000498)2.24741124
54Ventricular tachycardia (HP:0004756)2.22650837
55Abnormality of the distal phalanges of the toes (HP:0010182)2.13347839
56Lip pit (HP:0100267)2.08107819
57Focal segmental glomerulosclerosis (HP:0000097)2.07896613
58Distal lower limb muscle weakness (HP:0009053)2.05935623
59Gastrointestinal atresia (HP:0002589)2.05806625
60Advanced eruption of teeth (HP:0006288)2.05443764
61Rectal prolapse (HP:0002035)2.04888934
62Natal tooth (HP:0000695)2.04185474
63Biliary tract neoplasm (HP:0100574)2.04018288
64Palmoplantar keratoderma (HP:0000982)2.02819994
65Periodontitis (HP:0000704)2.02294739
66Corneal erosion (HP:0200020)1.96566888
67Septate vagina (HP:0001153)1.92973172
68* Hypodontia (HP:0000668)1.92899781
69Cerebral inclusion bodies (HP:0100314)1.92813744
70Subacute progressive viral hepatitis (HP:0006572)1.90666619
71Flat acetabular roof (HP:0003180)1.90282242
72Glomerulosclerosis (HP:0000096)1.90107878
73Breast hypoplasia (HP:0003187)1.88003847
74Hyperactive renin-angiotensin system (HP:0000841)1.87524878
75Poikiloderma (HP:0001029)1.87350683
76Pustule (HP:0200039)1.84721342
77Hypoplastic labia majora (HP:0000059)1.83784155
78Erythema (HP:0010783)1.83775397
79Selective tooth agenesis (HP:0001592)1.83186970
80Epidermoid cyst (HP:0200040)1.81929578
81* Death in infancy (HP:0001522)1.80473028
82Split foot (HP:0001839)1.80421150
83Ulnar bowing (HP:0003031)1.78875177
84Abnormality of the nasal septum (HP:0000419)1.78787449
85Vascular calcification (HP:0004934)1.76284083
86Germ cell neoplasia (HP:0100728)1.75896745
87Ankyloglossia (HP:0010296)1.73621195
88Trismus (HP:0000211)1.72573724
89Hoarse voice (HP:0001609)1.72225120
90Labial hypoplasia (HP:0000066)1.71636373
91Abnormality of the 2nd finger (HP:0004100)1.70881221
92Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.70753783
93Vertebral arch anomaly (HP:0008438)1.70611400
94Abnormal vertebral ossification (HP:0100569)1.69695279
95* Skin ulcer (HP:0200042)1.68966217
96Cardiovascular calcification (HP:0011915)1.68783866
97Osteolytic defects of the hand bones (HP:0009699)1.68695727
98Osteolytic defects of the phalanges of the hand (HP:0009771)1.68695727
99Unilateral renal agenesis (HP:0000122)1.68127319
100Mildly elevated creatine phosphokinase (HP:0008180)1.68011358
101Aplasia involving bones of the extremities (HP:0009825)1.67758346
102Aplasia involving bones of the upper limbs (HP:0009823)1.67758346
103Aplasia of the phalanges of the hand (HP:0009802)1.67758346
104Corneal dystrophy (HP:0001131)1.66151597
105Abnormality of the labia majora (HP:0012881)1.65752502
106Arterial tortuosity (HP:0005116)1.65401356
107Laryngomalacia (HP:0001601)1.65101263
108* Dehydration (HP:0001944)1.64714067
109Ectropion (HP:0000656)1.64369003
110Esophageal varix (HP:0002040)1.63401966
111Acanthosis nigricans (HP:0000956)1.61545982
112Broad face (HP:0000283)1.60302115
113Abnormality of the distal phalanx of the thumb (HP:0009617)1.60128365
114Increased connective tissue (HP:0009025)1.59868326
115Hypoplastic female external genitalia (HP:0012815)1.59668748
116Abnormality of the dental root (HP:0006486)1.59107550
117Taurodontia (HP:0000679)1.59107550
118Abnormality of permanent molar morphology (HP:0011071)1.59107550
119Aortic aneurysm (HP:0004942)1.57879044
120Bowed forearm bones (HP:0003956)1.57285947
121Bowing of the arm (HP:0006488)1.57285947
122Short hallux (HP:0010109)1.56471627
123Hypoplasia of the uterus (HP:0000013)1.56298003
124Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.56245600
125Cerebral aneurysm (HP:0004944)1.55555376
126Radial bowing (HP:0002986)1.55477106
127Down-sloping shoulders (HP:0200021)1.55103507
128Gastrointestinal carcinoma (HP:0002672)1.54012607
129Malignant gastrointestinal tract tumors (HP:0006749)1.54012607
130Premature rupture of membranes (HP:0001788)1.53701192
131* Abnormality of the fingernails (HP:0001231)1.53621932
132Back pain (HP:0003418)1.53206701
133Tibial bowing (HP:0002982)1.52593274
134Follicular hyperkeratosis (HP:0007502)1.52390532
135Short nail (HP:0001799)1.52383033
136Nasolacrimal duct obstruction (HP:0000579)1.52289487
137Cervical subluxation (HP:0003308)1.51732965
138Vascular tortuosity (HP:0004948)1.51685731
139Uterine neoplasm (HP:0010784)1.50864051
140Squamous cell carcinoma (HP:0002860)1.50773108
141Premature loss of primary teeth (HP:0006323)1.50278413
142Abnormality of the middle phalanges of the toes (HP:0010183)1.50051961
143Weak cry (HP:0001612)1.49778138
144* Hyperhidrosis (HP:0000975)1.49054954
145Abnormality of molar (HP:0011077)1.44548984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA29.19603966
2ARAF5.25593757
3MST43.75183806
4NTRK13.12623621
5LATS13.05182172
6FER2.98699338
7MAP3K32.74784791
8MST1R2.70573467
9EPHB22.11617890
10EPHB12.07237995
11RPS6KB21.95303367
12PTK61.94461051
13FRK1.93918971
14PTK21.92666149
15PAK41.89809662
16LRRK21.77538785
17RIPK11.74605424
18MAP3K21.71032134
19TRIB31.66962793
20FLT31.66606991
21MET1.64706489
22TESK11.62887731
23NME11.62505968
24BRAF1.61481518
25EPHA31.56615646
26MAPKAPK31.47129088
27STK101.46245420
28TRPM71.45581377
29RAF11.43181237
30ERN11.32084520
31TTN1.28406662
32MAP2K21.19989888
33MAPK151.16015991
34TGFBR21.13697051
35FGFR41.10448622
36STK31.10051270
37DDR21.09559255
38BCR1.04335166
39EEF2K1.04303538
40PKN21.03947042
41STK38L1.03379855
42STK241.03041172
43CDK61.02036605
44ERBB30.99732384
45RPS6KA20.96146155
46DMPK0.95615671
47RPS6KA40.94881983
48BMX0.91793121
49PRKCI0.86645476
50CSF1R0.86278123
51FGFR10.84158256
52FGFR20.84001814
53MAP2K10.82288323
54LMTK20.79784783
55PDGFRA0.76982107
56TGFBR10.75572035
57SIK10.72434097
58ERBB20.71495431
59KSR10.71170351
60LATS20.71153152
61STK380.71043472
62MAP3K130.70944166
63MOS0.69940800
64NUAK10.69851063
65SMG10.69683048
66MAP3K60.69310727
67CHUK0.68872206
68NME20.68348680
69MAP3K10.67849137
70PAK20.67147014
71LIMK10.66134926
72PIK3CA0.64079999
73TAOK10.63293276
74DYRK1B0.61940039
75FGFR30.59067141
76IRAK30.58709936
77PRKG20.57289695
78MYLK0.55189733
79MAP3K80.54349578
80PDGFRB0.51961760
81ILK0.51320241
82GSK3A0.50848029
83PIM20.49797336
84PAK30.48533522
85AKT30.43919103
86MAPKAPK20.43352176
87PTK2B0.41338402
88CDK120.39623752
89TIE10.39464052
90MAP3K70.39258028
91STK390.36544812
92NEK60.36350974
93PRPF4B0.36277574
94RPS6KC10.34660405
95RPS6KL10.34660405
96MTOR0.34520159
97MAP3K110.34015646
98ROCK10.33940664
99MELK0.33913664
100MATK0.33119934
101SIK30.32571872
102ROCK20.31956351
103EGFR0.31474811
104EIF2AK20.31084804
105PRKD10.29832681
106PBK0.29654734
107AURKB0.28271256
108SRC0.28219640
109MAP3K90.28046270
110NLK0.27362398
111MAP3K120.26919675
112PHKG10.26772952
113PHKG20.26772952
114SGK30.26619343
115ABL20.26199875
116RPS6KA10.25051783
117CSK0.25047820
118TSSK60.24943438
119RET0.24389458
120JAK30.23948434
121PRKD20.23772795
122CAMK2G0.23739181
123WNK40.22918826
124RPS6KB10.22893817
125CDC42BPA0.22798937
126MAP2K30.22783364
127IGF1R0.22704061
128JAK10.22438551
129MAP2K60.22133920
130RPS6KA60.22090924
131SCYL20.21890352
132PRKCE0.21646565
133IKBKB0.20531701
134ABL10.19686333
135ERBB40.19021313
136INSR0.18680899
137FYN0.18630850
138ADRBK10.18413585
139KSR20.17059527
140ALK0.14304184

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045124.01747973
2Adherens junction_Homo sapiens_hsa045203.16233350
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.89318375
4* Small cell lung cancer_Homo sapiens_hsa052222.75754216
5Tight junction_Homo sapiens_hsa045302.66436163
6Hippo signaling pathway_Homo sapiens_hsa043902.65782343
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.53232776
8Steroid biosynthesis_Homo sapiens_hsa001002.50605018
9Bladder cancer_Homo sapiens_hsa052192.48767662
10* Focal adhesion_Homo sapiens_hsa045102.36050928
11Basal cell carcinoma_Homo sapiens_hsa052172.28612813
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.27598061
13Proteoglycans in cancer_Homo sapiens_hsa052052.22790479
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.09658671
15Leukocyte transendothelial migration_Homo sapiens_hsa046702.05600787
16* Amoebiasis_Homo sapiens_hsa051461.99316227
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.89430123
18Thyroid cancer_Homo sapiens_hsa052161.82125888
19* Toxoplasmosis_Homo sapiens_hsa051451.74231500
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.67843136
21TGF-beta signaling pathway_Homo sapiens_hsa043501.61801924
22Hedgehog signaling pathway_Homo sapiens_hsa043401.60828108
23Mineral absorption_Homo sapiens_hsa049781.51986072
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.46671478
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.45279003
26Prion diseases_Homo sapiens_hsa050201.41293074
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40123145
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.40108944
29MicroRNAs in cancer_Homo sapiens_hsa052061.39374030
30Endometrial cancer_Homo sapiens_hsa052131.39360517
31Sphingolipid metabolism_Homo sapiens_hsa006001.32418948
32* Pathways in cancer_Homo sapiens_hsa052001.30492754
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.29911794
34Dilated cardiomyopathy_Homo sapiens_hsa054141.25926649
35Wnt signaling pathway_Homo sapiens_hsa043101.21756960
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20096474
37Protein digestion and absorption_Homo sapiens_hsa049741.19724825
38Chronic myeloid leukemia_Homo sapiens_hsa052201.12884845
39Pancreatic cancer_Homo sapiens_hsa052121.11601068
40TNF signaling pathway_Homo sapiens_hsa046681.09817411
41* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.07642037
42p53 signaling pathway_Homo sapiens_hsa041151.04905419
43Thyroid hormone synthesis_Homo sapiens_hsa049181.02665165
44Shigellosis_Homo sapiens_hsa051311.00234552
45Hepatitis C_Homo sapiens_hsa051601.00203587
46N-Glycan biosynthesis_Homo sapiens_hsa005100.97046944
47Vibrio cholerae infection_Homo sapiens_hsa051100.94810967
48Viral myocarditis_Homo sapiens_hsa054160.94381719
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94321245
50Rap1 signaling pathway_Homo sapiens_hsa040150.94317836
51Melanoma_Homo sapiens_hsa052180.94020622
52Renal cell carcinoma_Homo sapiens_hsa052110.92250692
53Salmonella infection_Homo sapiens_hsa051320.91626884
54Notch signaling pathway_Homo sapiens_hsa043300.91262250
55Melanogenesis_Homo sapiens_hsa049160.87978422
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87839159
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85207047
58Apoptosis_Homo sapiens_hsa042100.85019057
59Prostate cancer_Homo sapiens_hsa052150.84951577
60Axon guidance_Homo sapiens_hsa043600.84606092
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83358363
62VEGF signaling pathway_Homo sapiens_hsa043700.81666042
63Non-small cell lung cancer_Homo sapiens_hsa052230.81319568
64Colorectal cancer_Homo sapiens_hsa052100.80033533
65Inositol phosphate metabolism_Homo sapiens_hsa005620.79785542
66HTLV-I infection_Homo sapiens_hsa051660.77112226
67Sulfur metabolism_Homo sapiens_hsa009200.77066842
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76644556
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74433224
70Hematopoietic cell lineage_Homo sapiens_hsa046400.73292425
71Insulin signaling pathway_Homo sapiens_hsa049100.71810106
72Pertussis_Homo sapiens_hsa051330.70106490
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69526222
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68981060
75HIF-1 signaling pathway_Homo sapiens_hsa040660.68571289
76Acute myeloid leukemia_Homo sapiens_hsa052210.66126132
77Galactose metabolism_Homo sapiens_hsa000520.65842695
78Renin secretion_Homo sapiens_hsa049240.64144717
79Dorso-ventral axis formation_Homo sapiens_hsa043200.62176509
80Antigen processing and presentation_Homo sapiens_hsa046120.61238296
81Platelet activation_Homo sapiens_hsa046110.59504722
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59345064
83Prolactin signaling pathway_Homo sapiens_hsa049170.58785177
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.58507118
85Endocytosis_Homo sapiens_hsa041440.57848790
86Glycerolipid metabolism_Homo sapiens_hsa005610.57278163
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54874794
88Estrogen signaling pathway_Homo sapiens_hsa049150.54752706
89Malaria_Homo sapiens_hsa051440.53113411
90ErbB signaling pathway_Homo sapiens_hsa040120.53047807
91Legionellosis_Homo sapiens_hsa051340.52644637
92GnRH signaling pathway_Homo sapiens_hsa049120.49928927
93Gastric acid secretion_Homo sapiens_hsa049710.49802460
94Influenza A_Homo sapiens_hsa051640.49561328
95Leishmaniasis_Homo sapiens_hsa051400.48899058
96Arachidonic acid metabolism_Homo sapiens_hsa005900.48742630
97Viral carcinogenesis_Homo sapiens_hsa052030.48372139
98Caffeine metabolism_Homo sapiens_hsa002320.47563984
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47007733
100Lysosome_Homo sapiens_hsa041420.46671433
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.44762467
102Insulin resistance_Homo sapiens_hsa049310.44673861
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44421862
104Glutathione metabolism_Homo sapiens_hsa004800.44405368
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.44389086
106Pancreatic secretion_Homo sapiens_hsa049720.44381421
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42600305
108Renin-angiotensin system_Homo sapiens_hsa046140.42500191
109Salivary secretion_Homo sapiens_hsa049700.40085522
110Phenylalanine metabolism_Homo sapiens_hsa003600.39807619
111Fatty acid biosynthesis_Homo sapiens_hsa000610.39571438
112Glioma_Homo sapiens_hsa052140.39313374
113Linoleic acid metabolism_Homo sapiens_hsa005910.38525356
114Phagosome_Homo sapiens_hsa041450.38305075
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38214942
116FoxO signaling pathway_Homo sapiens_hsa040680.36616273
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36507256
118Ras signaling pathway_Homo sapiens_hsa040140.36126298
119Hepatitis B_Homo sapiens_hsa051610.35439762
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.34539409
121Gap junction_Homo sapiens_hsa045400.32728518
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29192049
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.27182322
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25692359
125Glucagon signaling pathway_Homo sapiens_hsa049220.21813192
126mTOR signaling pathway_Homo sapiens_hsa041500.21675306
127Long-term depression_Homo sapiens_hsa047300.21262982

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »