LAMC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 3. The gamma 3 chain is most similar to the gamma 1 chain, and contains all the 6 domains expected of the gamma chain. It is a component of laminin 12. The gamma 3 chain is broadly expressed in skin, heart, lung, and the reproductive tracts. In skin, it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration. Gamma 3 is also a prominent element of the apical surface of ciliated epithelial cells of lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of male gonad development (GO:2000020)7.38527665
2sex determination (GO:0007530)7.31369699
3regulation of male gonad development (GO:2000018)6.40628462
4regulation of meiosis I (GO:0060631)6.33896952
5anatomical structure regression (GO:0060033)6.29361593
6piRNA metabolic process (GO:0034587)6.14441142
7sex differentiation (GO:0007548)5.87283339
8glomerular basement membrane development (GO:0032836)5.86988781
9male sex determination (GO:0030238)5.13954103
10synaptonemal complex assembly (GO:0007130)5.07778792
11glucocorticoid biosynthetic process (GO:0006704)4.99846469
12male meiosis (GO:0007140)4.96681469
13synaptonemal complex organization (GO:0070193)4.77075863
14regulation of gonadotropin secretion (GO:0032276)4.64260885
15protein heterotrimerization (GO:0070208)4.54201268
16fusion of sperm to egg plasma membrane (GO:0007342)4.39984694
17oocyte development (GO:0048599)4.39371479
18homocysteine metabolic process (GO:0050667)4.36807348
19regulation of posttranscriptional gene silencing (GO:0060147)4.19318382
20regulation of gene silencing by miRNA (GO:0060964)4.19318382
21regulation of gene silencing by RNA (GO:0060966)4.19318382
22DNA methylation involved in gamete generation (GO:0043046)4.10425164
23ovulation cycle (GO:0042698)3.99508808
24protein-cofactor linkage (GO:0018065)3.78916638
25positive regulation of catenin import into nucleus (GO:0035413)3.74459407
26negative regulation of androgen receptor signaling pathway (GO:0060766)3.69807445
27regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.68198128
28plasma membrane fusion (GO:0045026)3.68058389
29regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.65379791
30positive regulation of meiosis (GO:0045836)3.65100499
31Leydig cell differentiation (GO:0033327)3.57387906
32macroautophagy (GO:0016236)3.53603062
33peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.52062466
34apoptotic cell clearance (GO:0043277)3.52025039
35establishment or maintenance of monopolar cell polarity (GO:0061339)3.48381458
36establishment of monopolar cell polarity (GO:0061162)3.48381458
37cell migration involved in heart development (GO:0060973)3.45480884
38lymphangiogenesis (GO:0001946)3.45133938
39convergent extension (GO:0060026)3.44038496
40basement membrane organization (GO:0071711)3.40679965
41positive regulation of meiotic cell cycle (GO:0051446)3.40432023
42dermatan sulfate biosynthetic process (GO:0030208)3.37326412
43regulation of mesoderm development (GO:2000380)3.36832942
44somite development (GO:0061053)3.35328967
45head development (GO:0060322)3.34688639
46positive regulation of SMAD protein import into nucleus (GO:0060391)3.33613109
47germ cell migration (GO:0008354)3.31692574
48cell proliferation involved in metanephros development (GO:0072203)3.27587629
49mesonephros development (GO:0001823)3.26715268
50atrial cardiac muscle cell action potential (GO:0086014)3.24489611
51androgen biosynthetic process (GO:0006702)3.20576701
52fat-soluble vitamin catabolic process (GO:0042363)3.20086070
53vitamin catabolic process (GO:0009111)3.20086070
54cell migration involved in gastrulation (GO:0042074)3.19277942
55anterior/posterior axis specification, embryo (GO:0008595)3.19018425
56collagen catabolic process (GO:0030574)3.18151784
57cornea development in camera-type eye (GO:0061303)3.14200747
58regulation of cell fate specification (GO:0042659)3.11205143
59atrioventricular valve morphogenesis (GO:0003181)3.10694624
60collagen metabolic process (GO:0032963)3.10597186
61polarized epithelial cell differentiation (GO:0030859)3.09158974
62L-alpha-amino acid transmembrane transport (GO:1902475)3.07020278
63cell proliferation involved in kidney development (GO:0072111)3.06321819
64genitalia morphogenesis (GO:0035112)3.05577217
65multicellular organismal macromolecule metabolic process (GO:0044259)3.03361718
66cellular response to gonadotropin stimulus (GO:0071371)3.02583470
67peripheral nervous system axon ensheathment (GO:0032292)3.02473138
68myelination in peripheral nervous system (GO:0022011)3.02473138
69cellular response to cholesterol (GO:0071397)3.00923289
70regulation of non-canonical Wnt signaling pathway (GO:2000050)3.00773486
71dermatan sulfate metabolic process (GO:0030205)2.99834152
72negative regulation of macrophage differentiation (GO:0045650)2.99732130
73embryonic foregut morphogenesis (GO:0048617)2.99406701
74negative regulation of T cell differentiation in thymus (GO:0033085)2.99394261
75multicellular organismal catabolic process (GO:0044243)2.98165133
76regulation of female gonad development (GO:2000194)2.92757078
77regulation of nuclear cell cycle DNA replication (GO:0033262)2.90337788
78branching involved in salivary gland morphogenesis (GO:0060445)2.89174978
79L-serine metabolic process (GO:0006563)2.88760355
80positive regulation of triglyceride biosynthetic process (GO:0010867)2.87886016
81stress fiber assembly (GO:0043149)2.85872129
82multicellular organismal metabolic process (GO:0044236)2.85683396
83regulation of SMAD protein import into nucleus (GO:0060390)2.85110557
84proximal/distal pattern formation (GO:0009954)2.84050970
85glucocorticoid metabolic process (GO:0008211)2.83522389
86negative regulation of cell fate specification (GO:0009996)2.82523483
87poly(A)+ mRNA export from nucleus (GO:0016973)2.82275584
88cell migration involved in sprouting angiogenesis (GO:0002042)2.81377883
89cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.79697838
90behavioral response to nicotine (GO:0035095)2.79632749
91positive regulation of reproductive process (GO:2000243)2.76745959
92cardiac right ventricle morphogenesis (GO:0003215)2.76186042
93response to follicle-stimulating hormone (GO:0032354)2.74966502
94glial cell proliferation (GO:0014009)2.74530312
95regulation of skeletal muscle cell differentiation (GO:2001014)2.74339683
96pre-miRNA processing (GO:0031054)2.74199796
97serine family amino acid catabolic process (GO:0009071)2.73841574
98bone trabecula formation (GO:0060346)2.73665305
99male genitalia development (GO:0030539)2.73305692
100regulation of catenin import into nucleus (GO:0035412)2.73021251
101endocardial cushion morphogenesis (GO:0003203)2.72989361
102notochord development (GO:0030903)2.72559532
103regulation of triglyceride biosynthetic process (GO:0010866)2.70948744
104growth hormone secretion (GO:0030252)2.70738748
105male meiosis I (GO:0007141)2.69874478
106renal system development (GO:0072001)2.69292718
107chromosome organization involved in meiosis (GO:0070192)2.69283871
108estrogen biosynthetic process (GO:0006703)2.68910939
109cell fate commitment involved in formation of primary germ layer (GO:0060795)2.68163428
110meiotic nuclear division (GO:0007126)2.67940459
111nucleobase biosynthetic process (GO:0046112)2.67335858
112adrenal gland development (GO:0030325)2.63301147
113gene silencing by RNA (GO:0031047)2.61983958
114metanephric mesenchyme development (GO:0072075)2.61634344
115extracellular matrix disassembly (GO:0022617)2.61615477
116chondrocyte proliferation (GO:0035988)2.60685502
117negative regulation of meiosis (GO:0045835)2.59937261
118outer ear morphogenesis (GO:0042473)2.59734029
119negative regulation of cell fate commitment (GO:0010454)2.59628897
120cellular response to interferon-alpha (GO:0035457)2.59135047
121regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.58986120
122positive regulation of macrophage cytokine production (GO:0060907)2.56072493
123cysteine metabolic process (GO:0006534)2.55771249
124dorsal/ventral axis specification (GO:0009950)2.54713094
125DNA replication checkpoint (GO:0000076)2.53302693
126hemoglobin metabolic process (GO:0020027)2.52525895
127glomerulus development (GO:0032835)2.52449955
128negative regulation of activin receptor signaling pathway (GO:0032926)2.51545601
129planar cell polarity pathway involved in neural tube closure (GO:0090179)2.51374527
130tonic smooth muscle contraction (GO:0014820)2.51348639
131regulation of hippo signaling (GO:0035330)2.51311643
132cellular response to sterol (GO:0036315)2.50468481
133sequestering of extracellular ligand from receptor (GO:0035581)2.50354246
134embryonic axis specification (GO:0000578)2.50319729
135establishment of epithelial cell polarity (GO:0090162)2.50265489
136lung-associated mesenchyme development (GO:0060484)2.49371095
137positive regulation of myotube differentiation (GO:0010831)2.48978033
138fibroblast migration (GO:0010761)2.48647273
139glomerular filtration (GO:0003094)2.47930826
140vascular endothelial growth factor signaling pathway (GO:0038084)2.47775175
141bone morphogenesis (GO:0060349)2.46674653
142lysine metabolic process (GO:0006553)2.45532614
143lysine catabolic process (GO:0006554)2.45532614
144adhesion of symbiont to host (GO:0044406)2.45409063
145regulation of protein polyubiquitination (GO:1902914)2.45027093
146lateral sprouting from an epithelium (GO:0060601)2.44271444
147dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44237912
148prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.43018251
149negative regulation of telomerase activity (GO:0051974)2.42612718
150establishment of nucleus localization (GO:0040023)2.42592932
151epithelial cell differentiation involved in prostate gland development (GO:0060742)2.42539980
152epithelial cell fate commitment (GO:0072148)2.39322469
153glomerular visceral epithelial cell development (GO:0072015)2.38727886
154genitalia development (GO:0048806)2.38682584
155skeletal muscle organ development (GO:0060538)2.36282904
156response to misfolded protein (GO:0051788)2.36227747
157embryonic pattern specification (GO:0009880)2.35983049
158complement activation, classical pathway (GO:0006958)2.35868316
159water-soluble vitamin biosynthetic process (GO:0042364)2.35744858
160endocardial cushion development (GO:0003197)2.35527362
161peptidyl-lysine dimethylation (GO:0018027)2.35507574
162non-canonical Wnt signaling pathway (GO:0035567)2.35336936
163regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.35205567
164glycine metabolic process (GO:0006544)2.34848297
165collagen fibril organization (GO:0030199)2.33227312
166establishment of apical/basal cell polarity (GO:0035089)2.33186436
167paraxial mesoderm development (GO:0048339)2.32772989
168receptor guanylyl cyclase signaling pathway (GO:0007168)2.32107181
169kidney mesenchyme development (GO:0072074)2.32097479
170negative regulation of catenin import into nucleus (GO:0035414)2.32060358
171renal filtration (GO:0097205)2.32035620
172drug transmembrane transport (GO:0006855)2.31573383
173peptidyl-histidine modification (GO:0018202)2.31031942
174somite rostral/caudal axis specification (GO:0032525)2.30918319
175establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.30677154
176vasculature development (GO:0001944)2.30102057
177epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.27376356
178enteric nervous system development (GO:0048484)2.27333012
179reverse cholesterol transport (GO:0043691)2.27325712
180epithelial cell-cell adhesion (GO:0090136)2.24636443
181response to gonadotropin (GO:0034698)2.24041631
182midgut development (GO:0007494)2.23483592
183cell surface receptor signaling pathway involved in heart development (GO:0061311)2.23272904
184regulation of cell fate commitment (GO:0010453)2.22544458
185regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.19567193
186regulation of activin receptor signaling pathway (GO:0032925)2.17605168
187gonadal mesoderm development (GO:0007506)10.7041746

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human5.17046073
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.11093267
3CLOCK_20551151_ChIP-Seq_293T_Human2.94400345
4ZNF263_19887448_ChIP-Seq_K562_Human2.56734050
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.47762724
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.46256778
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.45534977
8VDR_22108803_ChIP-Seq_LS180_Human2.42669661
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.34066300
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.34066300
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.34066300
12WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.25242192
13DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.12578931
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.12164780
15ZNF274_21170338_ChIP-Seq_K562_Hela2.03681999
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.01884185
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.97303657
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93857105
19POU5F1_16153702_ChIP-ChIP_HESCs_Human1.89349744
20* KDM2B_26808549_Chip-Seq_K562_Human1.88167075
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84178787
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.81478892
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79823008
24TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.78898723
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.78004287
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73763145
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73763145
28DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.73349557
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.72958276
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72658433
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69830668
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.67619593
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.65876299
34E2F7_22180533_ChIP-Seq_HELA_Human1.63908874
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62902007
36KDM2B_26808549_Chip-Seq_DND41_Human1.61520094
37RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.60935746
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59954249
39* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55328421
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54539034
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54535302
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51817763
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51016994
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.49814169
45DROSHA_22980978_ChIP-Seq_HELA_Human1.49215381
46ISL1_27105846_Chip-Seq_CPCs_Mouse1.48582508
47AR_21572438_ChIP-Seq_LNCaP_Human1.46338076
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46212058
49RUNX1_27514584_Chip-Seq_MCF-7_Human1.43621581
50CTCF_27219007_Chip-Seq_Bcells_Human1.42747665
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42234111
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.42179410
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41040508
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40854076
55ZFP281_27345836_Chip-Seq_ESCs_Mouse1.40152009
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38904918
57EZH2_22144423_ChIP-Seq_EOC_Human1.38264678
58LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38045247
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.36508205
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34939970
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.34498854
62EWS_26573619_Chip-Seq_HEK293_Human1.32756877
63TCF3_18692474_ChIP-Seq_MESCs_Mouse1.32261930
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.31888937
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.31602597
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31311849
67CREB1_26743006_Chip-Seq_LNCaP_Human1.29790112
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.29744681
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.28671872
70* TCF7_22412390_ChIP-Seq_EML_Mouse1.27713219
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27509697
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26162985
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26046697
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26038141
75SMAD3_21741376_ChIP-Seq_ESCs_Human1.25938120
76POU5F1_16518401_ChIP-PET_MESCs_Mouse1.25017005
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24653339
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24611386
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.23207225
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.21658890
81TBX20_22328084_ChIP-Seq_HEART_Mouse1.21403677
82TBX20_22080862_ChIP-Seq_HEART_Mouse1.21403677
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21316786
84RACK7_27058665_Chip-Seq_MCF-7_Human1.20575841
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20073963
86SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20022957
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19555833
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18698469
89GBX2_23144817_ChIP-Seq_PC3_Human1.18642542
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17996663
91LXR_22292898_ChIP-Seq_THP-1_Human1.17541981
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17354786
93FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16463181
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.16201485
95* SMAD3_21741376_ChIP-Seq_HESCs_Human1.16119374
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.14893905
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14830131
98TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14543079
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13882516
100TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13340860
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13049126
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12637898
103TP53_20018659_ChIP-ChIP_R1E_Mouse1.11682701
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.11632572
105* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10981481
106* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10408295
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09999088
108MYC_18555785_ChIP-Seq_MESCs_Mouse1.09981711
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09932516
110TP53_16413492_ChIP-PET_HCT116_Human1.08529704
111ELK3_25401928_ChIP-Seq_HUVEC_Human1.08451736
112* SMAD4_21741376_ChIP-Seq_HESCs_Human1.08271371
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.08033766
114TP53_22127205_ChIP-Seq_IMR90_Human1.07411613
115RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07401459
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.06632401
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06516242
118AHR_22903824_ChIP-Seq_MCF-7_Human1.06206466
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05702506
120EZH2_27294783_Chip-Seq_ESCs_Mouse1.05606035
121SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.05570087
122CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05477379
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05285894
124GATA1_26923725_Chip-Seq_HPCs_Mouse1.04755830
125FOXA2_19822575_ChIP-Seq_HepG2_Human1.04266776
126BCAT_22108803_ChIP-Seq_LS180_Human1.03914549
127* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02635271
128TCF4_18268006_ChIP-ChIP_LS174T_Human1.01606187
129KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01267428
130RNF2_27304074_Chip-Seq_NSC_Mouse1.01249987
131HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00890284
132PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.00835408
133KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98824044
134UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97768414
135STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97125934
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96873956
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96857747
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95884783
139BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94444034
140ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93984867
141TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93462060
142NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93238920
143SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92874123
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92020701
145PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.91847123
146SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91421258
147KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90249601
148PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89136483
149GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88324721
150P53_21459846_ChIP-Seq_SAOS-2_Human0.88290798
151THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88224546
152P300_19829295_ChIP-Seq_ESCs_Human0.88091367
153PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87560266
154TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.86836770
155MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86445423
156KDM2B_26808549_Chip-Seq_REH_Human0.83581359
157MYC_18940864_ChIP-ChIP_HL60_Human0.82653864
158SMAD3_21741376_ChIP-Seq_EPCs_Human0.80246908
159PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79974778
160FOXH1_21741376_ChIP-Seq_ESCs_Human0.79931239
161NANOG_16153702_ChIP-ChIP_HESCs_Human0.79830810
162ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.78894866
163STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.78124462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.71628612
2MP0008995_early_reproductive_senescence5.40015481
3MP0003878_abnormal_ear_physiology4.62219159
4MP0005377_hearing/vestibular/ear_phenot4.62219159
5MP0004272_abnormal_basement_membrane4.13274627
6MP0008877_abnormal_DNA_methylation4.07137557
7MP0008438_abnormal_cutaneous_collagen3.76635276
8MP0001661_extended_life_span3.11379837
9MP0001958_emphysema3.10198158
10MP0005503_abnormal_tendon_morphology2.60700085
11MP0000751_myopathy2.53549955
12MP0003045_fibrosis2.41035121
13MP0005275_abnormal_skin_tensile2.29999517
14MP0010030_abnormal_orbit_morphology2.29983018
15MP0003195_calcinosis2.25105159
16MP0003136_yellow_coat_color2.24586346
17MP0004133_heterotaxia2.16064939
18MP0003890_abnormal_embryonic-extraembry2.12110635
19MP0000049_abnormal_middle_ear2.05748737
20MP0005647_abnormal_sex_gland1.99382491
21MP0000537_abnormal_urethra_morphology1.93750216
22MP0003705_abnormal_hypodermis_morpholog1.91206410
23MP0005167_abnormal_blood-brain_barrier1.86451900
24MP0004858_abnormal_nervous_system1.78354470
25MP0005623_abnormal_meninges_morphology1.77134260
26MP0002210_abnormal_sex_determination1.68656012
27MP0003937_abnormal_limbs/digits/tail_de1.68402843
28MP0002168_other_aberrant_phenotype1.67109777
29MP0005187_abnormal_penis_morphology1.66609990
30MP0003115_abnormal_respiratory_system1.62141053
31MP0003567_abnormal_fetal_cardiomyocyte1.60689691
32MP0005076_abnormal_cell_differentiation1.59915145
33MP0009384_cardiac_valve_regurgitation1.57277237
34MP0003786_premature_aging1.56760815
35MP0009278_abnormal_bone_marrow1.55062472
36MP0009250_abnormal_appendicular_skeleto1.53268317
37MP0006072_abnormal_retinal_apoptosis1.52687294
38MP0001145_abnormal_male_reproductive1.51902348
39MP0003879_abnormal_hair_cell1.51506241
40MP0009780_abnormal_chondrocyte_physiolo1.46576772
41MP0004084_abnormal_cardiac_muscle1.46073167
42MP0006138_congestive_heart_failure1.46057117
43MP0001727_abnormal_embryo_implantation1.42561211
44MP0008057_abnormal_DNA_replication1.41692544
45MP0010368_abnormal_lymphatic_system1.39375483
46MP0001485_abnormal_pinna_reflex1.38688892
47MP0001929_abnormal_gametogenesis1.38263175
48MP0003942_abnormal_urinary_system1.37467773
49MP0003315_abnormal_perineum_morphology1.32865678
50MP0003936_abnormal_reproductive_system1.31005769
51MP0002108_abnormal_muscle_morphology1.30716662
52MP0000428_abnormal_craniofacial_morphol1.30146290
53MP0005410_abnormal_fertilization1.29799698
54MP0000653_abnormal_sex_gland1.29615646
55MP0003718_maternal_effect1.28959410
56MP0002697_abnormal_eye_size1.22932431
57MP0004134_abnormal_chest_morphology1.22717546
58MP0005248_abnormal_Harderian_gland1.22647223
59MP0002163_abnormal_gland_morphology1.19246241
60MP0005670_abnormal_white_adipose1.17217210
61MP0000534_abnormal_ureter_morphology1.17100493
62MP0002295_abnormal_pulmonary_circulatio1.14982134
63MP0000579_abnormal_nail_morphology1.14198146
64MP0000762_abnormal_tongue_morphology1.14008318
65MP0002102_abnormal_ear_morphology1.13412500
66MP0003698_abnormal_male_reproductive1.13247891
67MP0003300_gastrointestinal_ulcer1.11705929
68MP0003693_abnormal_embryo_hatching1.11574412
69MP0003123_paternal_imprinting1.11458431
70MP0002909_abnormal_adrenal_gland1.11027625
71MP0000631_abnormal_neuroendocrine_gland1.10338827
72MP0002111_abnormal_tail_morphology1.09423390
73MP0002896_abnormal_bone_mineralization1.09167507
74MP0002234_abnormal_pharynx_morphology1.07861932
75MP0005253_abnormal_eye_physiology1.04767609
76MP0003283_abnormal_digestive_organ1.04145475
77MP0002084_abnormal_developmental_patter1.03423424
78MP0000566_synostosis1.03412032
79MP0004885_abnormal_endolymph1.03184208
80MP0005379_endocrine/exocrine_gland_phen1.02559926
81MP0002938_white_spotting1.02555821
82MP0004036_abnormal_muscle_relaxation1.00021379
83MP0008932_abnormal_embryonic_tissue0.99349557
84MP0005551_abnormal_eye_electrophysiolog0.98390563
85MP0000462_abnormal_digestive_system0.96762393
86MP0000432_abnormal_head_morphology0.96697432
87MP0000639_abnormal_adrenal_gland0.96569986
88MP0000427_abnormal_hair_cycle0.95919656
89MP0001188_hyperpigmentation0.93767902
90MP0003385_abnormal_body_wall0.92115621
91MP0001243_abnormal_dermal_layer0.91586900
92MP0003137_abnormal_impulse_conducting0.89231720
93MP0003941_abnormal_skin_development0.88338617
94MP0005257_abnormal_intraocular_pressure0.87745108
95MP0003279_aneurysm0.86289587
96MP0002089_abnormal_postnatal_growth/wei0.85919986
97MP0002282_abnormal_trachea_morphology0.85829325
98MP0003011_delayed_dark_adaptation0.85393961
99MP0008961_abnormal_basal_metabolism0.84981538
100MP0009840_abnormal_foam_cell0.84422418
101MP0001502_abnormal_circadian_rhythm0.84162032
102MP0002009_preneoplasia0.84148812
103MP0002060_abnormal_skin_morphology0.83715317
104MP0005508_abnormal_skeleton_morphology0.83192897
105MP0003787_abnormal_imprinting0.81946669
106MP0000516_abnormal_urinary_system0.81772407
107MP0005367_renal/urinary_system_phenotyp0.81772407
108MP0004782_abnormal_surfactant_physiolog0.81748894
109MP0001879_abnormal_lymphatic_vessel0.81595109
110MP0002085_abnormal_embryonic_tissue0.81360592
111MP0010234_abnormal_vibrissa_follicle0.81118048
112MP0003935_abnormal_craniofacial_develop0.79153521
113MP0000767_abnormal_smooth_muscle0.78891393
114MP0005174_abnormal_tail_pigmentation0.78865209
115MP0003091_abnormal_cell_migration0.78330278
116MP0001299_abnormal_eye_distance/0.77756191
117MP0000003_abnormal_adipose_tissue0.77484738
118MP0008775_abnormal_heart_ventricle0.77274502
119MP0001672_abnormal_embryogenesis/_devel0.76656750
120MP0005380_embryogenesis_phenotype0.76656750
121MP0006054_spinal_hemorrhage0.76498875
122MP0000383_abnormal_hair_follicle0.76464368
123MP0005391_vision/eye_phenotype0.76177793
124MP0003861_abnormal_nervous_system0.73841294
125MP0005595_abnormal_vascular_smooth0.73510486
126MP0002088_abnormal_embryonic_growth/wei0.72947408
127MP0003755_abnormal_palate_morphology0.72826951
128MP0005375_adipose_tissue_phenotype0.72544726
129MP0004147_increased_porphyrin_level0.72521189
130MP0000647_abnormal_sebaceous_gland0.72473586
131MP0005171_absent_coat_pigmentation0.71811185
132MP0010678_abnormal_skin_adnexa0.71554494
133MP0001340_abnormal_eyelid_morphology0.71439918
134MP0003984_embryonic_growth_retardation0.71054098
135MP0000013_abnormal_adipose_tissue0.70784564
136MP0005666_abnormal_adipose_tissue0.70588341
137MP0001286_abnormal_eye_development0.70546697
138MP0003119_abnormal_digestive_system0.69991699
139MP0002128_abnormal_blood_circulation0.69394208
140MP0004085_abnormal_heartbeat0.69216904
141MP0002932_abnormal_joint_morphology0.68981802
142MP0004233_abnormal_muscle_weight0.68493145
143MP0005646_abnormal_pituitary_gland0.68156124
144MP0009672_abnormal_birth_weight0.67952612
145MP0002115_abnormal_skeleton_extremities0.67780893
146MP0004264_abnormal_extraembryonic_tissu0.67268226
147MP0002116_abnormal_craniofacial_bone0.66603442
148MP0004145_abnormal_muscle_electrophysio0.66148762
149MP0002751_abnormal_autonomic_nervous0.65967089
150MP0000733_abnormal_muscle_development0.65722532
151MP0000569_abnormal_digit_pigmentation0.64922756
152MP0003121_genomic_imprinting0.64843613
153MP0000026_abnormal_inner_ear0.64701775
154MP0003122_maternal_imprinting0.63348866
155MP0004197_abnormal_fetal_growth/weight/0.63343729
156MP0002925_abnormal_cardiovascular_devel0.62540906
157MP0009053_abnormal_anal_canal0.62333369
158MP0004742_abnormal_vestibular_system0.61724610
159MP0002092_abnormal_eye_morphology0.61582074
160MP0003828_pulmonary_edema0.60501225
161MP0002160_abnormal_reproductive_system0.60160248
162MP0001756_abnormal_urination0.60134086
163MP0002133_abnormal_respiratory_system0.59421684

Predicted human phenotypes

RankGene SetZ-score
1Gonadal dysgenesis (HP:0000133)5.51133040
2Male infertility (HP:0003251)5.50878034
3Ankle contracture (HP:0006466)5.12265304
4Gonadotropin excess (HP:0000837)4.94949926
5Short 4th metacarpal (HP:0010044)4.35638242
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.35638242
7Bladder diverticulum (HP:0000015)3.91470235
8Cerebral aneurysm (HP:0004944)3.70914745
9Follicular hyperkeratosis (HP:0007502)3.63817546
10Hypoventilation (HP:0002791)3.63172913
11Testicular neoplasm (HP:0010788)3.59867451
12Abnormality of the parietal bone (HP:0002696)3.57492977
13Neoplasm of the heart (HP:0100544)3.55276575
14Protrusio acetabuli (HP:0003179)3.51584769
15Hand muscle atrophy (HP:0009130)3.43939863
16Renovascular hypertension (HP:0100817)3.38176945
17Abnormality of the 4th metacarpal (HP:0010012)3.33544378
18Aortic dissection (HP:0002647)3.30937748
19Male pseudohermaphroditism (HP:0000037)3.29363538
20Type 1 muscle fiber predominance (HP:0003803)3.26045670
21Broad metatarsal (HP:0001783)3.24665481
22Short tibia (HP:0005736)3.23955073
23Abnormal sex determination (HP:0012244)3.16127349
24Sex reversal (HP:0012245)3.16127349
25Aplasia/Hypoplasia of the tibia (HP:0005772)3.13880115
26Cerebellar dysplasia (HP:0007033)3.12976051
27Increased variability in muscle fiber diameter (HP:0003557)3.05110320
28Preaxial foot polydactyly (HP:0001841)3.02542438
29Shallow orbits (HP:0000586)3.00902987
30Aplasia/Hypoplasia of the hallux (HP:0008362)2.97027131
31Short hallux (HP:0010109)2.96516645
32Rectal prolapse (HP:0002035)2.94674183
33Azoospermia (HP:0000027)2.93365043
34Premature rupture of membranes (HP:0001788)2.93210663
35Decreased circulating renin level (HP:0003351)2.90522756
36Aortic aneurysm (HP:0004942)2.87570081
37Midline defect of the nose (HP:0004122)2.86740966
38Abnormality of the diencephalon (HP:0010662)2.84876370
39Upper limb amyotrophy (HP:0009129)2.83242115
40Distal upper limb amyotrophy (HP:0007149)2.83242115
41Facial diplegia (HP:0001349)2.82338980
42Birth length less than 3rd percentile (HP:0003561)2.80904854
43Hyperacusis (HP:0010780)2.80882632
44Atrophic scars (HP:0001075)2.73334987
45Metaphyseal cupping (HP:0003021)2.72505587
46Renal duplication (HP:0000075)2.71693086
47Overriding aorta (HP:0002623)2.68723043
48Slender build (HP:0001533)2.68248578
49Milia (HP:0001056)2.67831043
50Germ cell neoplasia (HP:0100728)2.66952583
51Mesangial abnormality (HP:0001966)2.58867422
52Humeroradial synostosis (HP:0003041)2.58865222
53Synostosis involving the elbow (HP:0003938)2.58865222
54Fibular hypoplasia (HP:0003038)2.55822623
55Elfin facies (HP:0004428)2.55753070
56Pulmonary artery stenosis (HP:0004415)2.55424653
57Abnormality of the middle phalanges of the toes (HP:0010183)2.53529504
58Increased connective tissue (HP:0009025)2.53136013
59Cutaneous finger syndactyly (HP:0010554)2.51352755
60Abnormality of skeletal muscle fiber size (HP:0012084)2.48686322
61Stridor (HP:0010307)2.48184678
62Flat cornea (HP:0007720)2.44485747
63Abnormality of male internal genitalia (HP:0000022)2.41512776
64Fragile skin (HP:0001030)2.41405870
65Lymphangioma (HP:0100764)2.40521801
66Hypoplasia of the iris (HP:0007676)2.39803763
67Abnormality of homocysteine metabolism (HP:0010919)2.38457714
68Homocystinuria (HP:0002156)2.38457714
69Mitral valve prolapse (HP:0001634)2.38116611
70Infertility (HP:0000789)2.37382756
71Bilateral microphthalmos (HP:0007633)2.37161807
72Complement deficiency (HP:0004431)2.35781355
73Supernumerary ribs (HP:0005815)2.34756011
74Trigonocephaly (HP:0000243)2.34636503
7511 pairs of ribs (HP:0000878)2.33545142
76Soft skin (HP:0000977)2.33048270
77Cutaneous syndactyly (HP:0012725)2.31330516
78Skull defect (HP:0001362)2.31280442
79Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.28212796
80Bronchomalacia (HP:0002780)2.27511860
81Abnormality of the lower motor neuron (HP:0002366)2.27175263
82Short phalanx of the thumb (HP:0009660)2.25206013
83Spinal rigidity (HP:0003306)2.24595525
84Insomnia (HP:0100785)2.21261239
85Mildly elevated creatine phosphokinase (HP:0008180)2.20221053
86Patent foramen ovale (HP:0001655)2.19683718
87Choanal stenosis (HP:0000452)2.19564061
88Renal salt wasting (HP:0000127)2.18823886
89Selective tooth agenesis (HP:0001592)2.18709462
90Bowel diverticulosis (HP:0005222)2.15771412
91Deformed sella turcica (HP:0002681)2.15519763
92Rib fusion (HP:0000902)2.13938477
93Turricephaly (HP:0000262)2.11347406
94Abnormality of the musculature of the hand (HP:0001421)2.10310427
95Cupped ear (HP:0000378)2.09524498
96Hypoplasia of the uterus (HP:0000013)2.09435175
97Abnormality of abdominal situs (HP:0011620)2.08797766
98Abdominal situs inversus (HP:0003363)2.08797766
99Absent toe (HP:0010760)2.08165210
100Vitreoretinal degeneration (HP:0000655)2.08141328
101Abnormal spermatogenesis (HP:0008669)2.07052889
102Abnormality of the vitreous humor (HP:0004327)2.05519100
103Aplasia/hypoplasia of the uterus (HP:0008684)2.05451886
104Abnormality of the distal phalanx of the thumb (HP:0009617)2.04120738
105Short humerus (HP:0005792)2.04108896
106Ankle clonus (HP:0011448)2.03247212
107Down-sloping shoulders (HP:0200021)2.02285793
108Limb-girdle muscle weakness (HP:0003325)2.02063094
109Abnormality of the peritoneum (HP:0002585)2.00539027
110Striae distensae (HP:0001065)2.00200450
111Aplasia/hypoplasia of the humerus (HP:0006507)1.97798698
112Aneurysm (HP:0002617)1.95888003
113Supernumerary bones of the axial skeleton (HP:0009144)1.94691164
114Aplasia/Hypoplasia of the fibula (HP:0006492)1.93913747
115Arachnodactyly (HP:0001166)1.93688384
116Tracheal stenosis (HP:0002777)1.92248522
117Coronal craniosynostosis (HP:0004440)1.91176145
118Hyperaldosteronism (HP:0000859)1.90379501
119Deviation of the hallux (HP:0010051)1.90124994
120Narrow palate (HP:0000189)1.89950381
121Dilatation of the ascending aorta (HP:0005111)1.88979946
122Hallux valgus (HP:0001822)1.88925860
123Type II lissencephaly (HP:0007260)1.87661845
124Bifid tongue (HP:0010297)1.86608480
125Neoplasm of the oral cavity (HP:0100649)1.85702531
126Duplicated collecting system (HP:0000081)1.85243304
127Thickened helices (HP:0000391)1.83538179
128Abnormal lung lobation (HP:0002101)1.83266436
129Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82532338
130Absent epiphyses (HP:0010577)1.82532338
131Abnormality of complement system (HP:0005339)1.82470935
132Venous insufficiency (HP:0005293)1.82395765
133Chorioretinal atrophy (HP:0000533)1.81714015
134Abnormality of renin-angiotensin system (HP:0000847)1.81703760
135Joint laxity (HP:0001388)1.81095821
136Aortic regurgitation (HP:0001659)1.80857685
137Aplasia involving bones of the upper limbs (HP:0009823)1.80552176
138Aplasia of the phalanges of the hand (HP:0009802)1.80552176
139Aplasia involving bones of the extremities (HP:0009825)1.80552176
140Hypoplasia of the pons (HP:0012110)1.80052564
141Occipital encephalocele (HP:0002085)1.79811384
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79443259
143Peritonitis (HP:0002586)1.79146690
144Depressed nasal tip (HP:0000437)1.78722600
145Flat face (HP:0012368)1.76687320
146Abnormality of the sella turcica (HP:0002679)1.76613211
147Hypoplasia of the ulna (HP:0003022)1.76548835
148Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76429915
149Enlarged penis (HP:0000040)1.75968055
150Abnormality of the aortic arch (HP:0012303)1.75414679
151Tubular atrophy (HP:0000092)1.75410763
152Abnormality of the renal collecting system (HP:0004742)1.75075608
153Oligodactyly (HP:0012165)1.74238199
154Ectopic kidney (HP:0000086)1.72821349
155Genu recurvatum (HP:0002816)1.71361283
156Anterior segment dysgenesis (HP:0007700)1.71318914
157Neoplasm of the adrenal cortex (HP:0100641)1.70610957
158Breast hypoplasia (HP:0003187)1.70187291
159Anophthalmia (HP:0000528)1.69023954
160Alkalosis (HP:0001948)1.67992291
161Non-midline cleft lip (HP:0100335)1.66793310
162Short chin (HP:0000331)1.66532840
163Abnormality of the pons (HP:0007361)1.66179176
164Pendular nystagmus (HP:0012043)1.65472538
165Ulnar bowing (HP:0003031)1.65221757
166Double outlet right ventricle (HP:0001719)1.64928819
167Congenital malformation of the right heart (HP:0011723)1.64928819
168Abnormality of dentin (HP:0010299)1.62669291
169Abnormality of sulfur amino acid metabolism (HP:0004339)1.62494029
170Absent radius (HP:0003974)1.61818231
171Abnormality of chromosome segregation (HP:0002916)1.61531503
172Bicornuate uterus (HP:0000813)1.60600345
173Metaphyseal dysplasia (HP:0100255)1.60150076
174Increased corneal curvature (HP:0100692)1.57929396
175Keratoconus (HP:0000563)1.57929396
176Transposition of the great arteries (HP:0001669)1.57595323
177Abnormal connection of the cardiac segments (HP:0011545)1.57595323
178Abnormal ventriculo-arterial connection (HP:0011563)1.57595323
179Gastrointestinal atresia (HP:0002589)1.57472008
180Hypokalemia (HP:0002900)1.56553576

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.78316758
2TLK13.74396928
3TYRO33.72669214
4RIPK13.52515253
5TRIB33.48783234
6LATS12.99732681
7PDGFRA2.77845235
8TIE12.63877644
9ICK2.61210625
10PRKD32.49627910
11SMG12.23463164
12WNK32.22019883
13ZAK2.15472541
14FRK2.13112513
15PTK62.10420819
16CAMK1G2.04479783
17MYLK2.01446364
18FGFR21.98746770
19CAMK1D1.97564364
20STK161.97124605
21VRK21.93163638
22NUAK11.91323390
23TAF11.83715604
24PTK2B1.78415379
25BMPR1B1.72533021
26PDK41.71932832
27PDK31.71932832
28SIK11.71394833
29OXSR11.67767617
30TSSK61.66463617
31NTRK31.65181428
32CDK31.60715409
33BRD41.60117160
34PAK21.59559997
35WNK41.59531631
36EPHB21.52612594
37DDR21.52210660
38EPHB11.49332655
39EEF2K1.45749739
40DMPK1.45321049
41MAP3K101.45028056
42WNK11.44478267
43DYRK31.41802189
44MAP4K21.41181558
45FER1.39800498
46CDK91.37707001
47MAP3K41.35397096
48NME11.34449328
49PKN21.32303325
50BMX1.31797083
51MKNK21.30113534
52DAPK21.29843137
53DYRK21.29397452
54ADRBK21.28181685
55MTOR1.27545042
56PDGFRB1.27336802
57WEE11.26575450
58GRK11.25220228
59STK31.23074846
60MAPK151.20647370
61PDK21.20620838
62KDR1.20446147
63TTN1.20336710
64CHEK21.18121945
65CDK71.16964606
66RPS6KA61.15815239
67FGFR11.14651264
68RPS6KA41.10664609
69PIK3CA1.08617631
70LMTK21.08569523
71ERN11.07669215
72LATS21.06764360
73RPS6KL11.05307994
74RPS6KC11.05307994
75TGFBR21.04035237
76INSRR1.02610811
77AKT31.02515386
78PTK20.95417940
79TNK20.95028139
80RPS6KA50.93350653
81PAK40.93116326
82MET0.92948573
83CSNK1A1L0.92566730
84CDK40.91537832
85FGFR40.89681606
86TTK0.88332097
87MAPKAPK50.87620864
88MKNK10.87316738
89TNIK0.86300314
90ACVR1B0.83033482
91CDC70.82510194
92MAP2K20.81344927
93CDC42BPA0.79939715
94ATR0.79606914
95HIPK20.79219611
96CSNK1G30.78125458
97RAF10.77378875
98RET0.75933575
99ERBB40.73814535
100PINK10.70102584
101TGFBR10.68091746
102PLK30.67175572
103GSK3A0.61890651
104PBK0.61735892
105ADRBK10.61700687
106MAP3K80.61657265
107BUB10.61147854
108PRKD20.60608168
109PRKCH0.60163335
110NEK20.58941061
111PLK40.58414193
112ROCK10.57733361
113SIK20.57127996
114STK390.56513833
115NTRK10.52199255
116MELK0.51573491
117RPS6KA10.51391362
118MAP3K20.50223123
119PAK60.50079180
120CDK60.49589832
121PRKAA10.49364556
122VRK10.46403749
123NLK0.46257947
124STK38L0.45672795
125NTRK20.45519884
126PRKCE0.44318234
127PNCK0.42390572
128CHUK0.41840042
129PRKCG0.41271047
130STK110.40326028
131PRKD10.39949477
132PRKG20.39034839
133MAPK10.38905841
134AKT20.38659811
135FGFR30.38219673
136ERBB20.37761381
137EGFR0.36857269
138MAP2K40.35519412
139PAK30.32627206
140SGK30.31334656
141RPS6KA20.30166360
142MAP3K70.29929073
143CSNK1G10.29386365
144PRKACB0.28571544
145STK380.28500652
146MAPK80.27922697
147KSR20.27093974
148MAPK30.26373815
149INSR0.25850982
150PRKAA20.24683054
151CSK0.24657810
152CAMK40.23950278
153CSNK1G20.23158277
154SRC0.22796706
155SGK4940.22459538
156SGK2230.22459538
157GSK3B0.21535235

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045123.15081046
2Protein digestion and absorption_Homo sapiens_hsa049743.13911432
3Hedgehog signaling pathway_Homo sapiens_hsa043403.12421186
4Basal cell carcinoma_Homo sapiens_hsa052172.94108674
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.87830613
6Sulfur relay system_Homo sapiens_hsa041222.66660755
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.59972093
8Dorso-ventral axis formation_Homo sapiens_hsa043202.59151447
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.39679207
10Vitamin B6 metabolism_Homo sapiens_hsa007502.34156610
11Selenocompound metabolism_Homo sapiens_hsa004502.32345692
12One carbon pool by folate_Homo sapiens_hsa006702.26571077
13Fatty acid biosynthesis_Homo sapiens_hsa000612.26386411
14Linoleic acid metabolism_Homo sapiens_hsa005912.26208211
15* Focal adhesion_Homo sapiens_hsa045102.07448252
16Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.96125601
17Lysine degradation_Homo sapiens_hsa003101.93833420
18* Amoebiasis_Homo sapiens_hsa051461.82142597
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78066756
20Tryptophan metabolism_Homo sapiens_hsa003801.77747398
21Folate biosynthesis_Homo sapiens_hsa007901.76423914
22Fatty acid metabolism_Homo sapiens_hsa012121.74427559
23Steroid biosynthesis_Homo sapiens_hsa001001.72273257
24TGF-beta signaling pathway_Homo sapiens_hsa043501.69797367
25RNA polymerase_Homo sapiens_hsa030201.69556118
26Notch signaling pathway_Homo sapiens_hsa043301.68484633
27Ovarian steroidogenesis_Homo sapiens_hsa049131.62986670
28* Small cell lung cancer_Homo sapiens_hsa052221.60821839
29Renin secretion_Homo sapiens_hsa049241.60687104
30Vitamin digestion and absorption_Homo sapiens_hsa049771.58396859
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57829574
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.49187025
33Axon guidance_Homo sapiens_hsa043601.46480203
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46187095
35PPAR signaling pathway_Homo sapiens_hsa033201.42385446
36Hippo signaling pathway_Homo sapiens_hsa043901.39913209
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.38882553
38Proteoglycans in cancer_Homo sapiens_hsa052051.36864501
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33835544
40Fat digestion and absorption_Homo sapiens_hsa049751.32875711
41Adherens junction_Homo sapiens_hsa045201.30802784
42Ether lipid metabolism_Homo sapiens_hsa005651.29726791
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29056981
44cAMP signaling pathway_Homo sapiens_hsa040241.26783131
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26031759
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24982260
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.21424139
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21087169
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18292813
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18277063
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17064604
52Wnt signaling pathway_Homo sapiens_hsa043101.16115103
53Adipocytokine signaling pathway_Homo sapiens_hsa049201.15393242
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15131745
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14045923
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13534958
57Fatty acid degradation_Homo sapiens_hsa000711.10628208
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.10516849
59Insulin resistance_Homo sapiens_hsa049311.08714378
60Estrogen signaling pathway_Homo sapiens_hsa049151.07988297
61Bile secretion_Homo sapiens_hsa049761.07616577
62Retinol metabolism_Homo sapiens_hsa008301.06967426
63* Pathways in cancer_Homo sapiens_hsa052001.05283196
64Complement and coagulation cascades_Homo sapiens_hsa046101.05191506
65Caffeine metabolism_Homo sapiens_hsa002321.04913757
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03670985
67Phototransduction_Homo sapiens_hsa047441.01150457
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00048480
69Tight junction_Homo sapiens_hsa045300.99370147
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.97008608
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95911196
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94210468
73Propanoate metabolism_Homo sapiens_hsa006400.93582730
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91037538
75* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.90967612
76Gastric acid secretion_Homo sapiens_hsa049710.90868837
77Arachidonic acid metabolism_Homo sapiens_hsa005900.90295902
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89862320
79Glycerolipid metabolism_Homo sapiens_hsa005610.88749319
80Pyruvate metabolism_Homo sapiens_hsa006200.88735418
81Viral myocarditis_Homo sapiens_hsa054160.88144110
82Arginine biosynthesis_Homo sapiens_hsa002200.87367546
83Prostate cancer_Homo sapiens_hsa052150.87357906
84Prion diseases_Homo sapiens_hsa050200.87266015
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85571850
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.85043349
87Endometrial cancer_Homo sapiens_hsa052130.84673656
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84438448
89Melanogenesis_Homo sapiens_hsa049160.83430850
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81900333
91Nitrogen metabolism_Homo sapiens_hsa009100.81605307
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80653867
93Glioma_Homo sapiens_hsa052140.80226046
94Mineral absorption_Homo sapiens_hsa049780.79681416
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79392062
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79115202
97MicroRNAs in cancer_Homo sapiens_hsa052060.78065224
98AMPK signaling pathway_Homo sapiens_hsa041520.76326639
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76310224
100Butanoate metabolism_Homo sapiens_hsa006500.75921262
101VEGF signaling pathway_Homo sapiens_hsa043700.75120119
102Dilated cardiomyopathy_Homo sapiens_hsa054140.74755594
103Rap1 signaling pathway_Homo sapiens_hsa040150.73434050
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72653862
105Homologous recombination_Homo sapiens_hsa034400.72070804
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.71482174
107Oxytocin signaling pathway_Homo sapiens_hsa049210.68491426
108Base excision repair_Homo sapiens_hsa034100.67665621
109Platelet activation_Homo sapiens_hsa046110.65887233
110Choline metabolism in cancer_Homo sapiens_hsa052310.65414432
111ABC transporters_Homo sapiens_hsa020100.64578038
112Cocaine addiction_Homo sapiens_hsa050300.64129584
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.64063760
114Purine metabolism_Homo sapiens_hsa002300.63930604
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63772358
116Colorectal cancer_Homo sapiens_hsa052100.63343325
117Thyroid hormone synthesis_Homo sapiens_hsa049180.63090827
118Glucagon signaling pathway_Homo sapiens_hsa049220.62985183
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.62819659
120Fanconi anemia pathway_Homo sapiens_hsa034600.62489639
121* Toxoplasmosis_Homo sapiens_hsa051450.61583740
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.60702195
123Chemical carcinogenesis_Homo sapiens_hsa052040.60337600
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60289808
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59545486
126Chronic myeloid leukemia_Homo sapiens_hsa052200.57800632
127Gap junction_Homo sapiens_hsa045400.56876607
128Type II diabetes mellitus_Homo sapiens_hsa049300.56766063
129Insulin signaling pathway_Homo sapiens_hsa049100.56561372
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56087228
131RNA transport_Homo sapiens_hsa030130.55767531
132mTOR signaling pathway_Homo sapiens_hsa041500.55718828
133Pyrimidine metabolism_Homo sapiens_hsa002400.55681773
134Arginine and proline metabolism_Homo sapiens_hsa003300.55646556
135HTLV-I infection_Homo sapiens_hsa051660.55614317
136Histidine metabolism_Homo sapiens_hsa003400.54752068
137Metabolic pathways_Homo sapiens_hsa011000.53992082
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53631064
139mRNA surveillance pathway_Homo sapiens_hsa030150.50341908
140ErbB signaling pathway_Homo sapiens_hsa040120.50021649
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.49167883
142Oocyte meiosis_Homo sapiens_hsa041140.49094831
143Salivary secretion_Homo sapiens_hsa049700.48926383
144Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48729368
145Serotonergic synapse_Homo sapiens_hsa047260.48116602
146Prolactin signaling pathway_Homo sapiens_hsa049170.47987224
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47530792
148beta-Alanine metabolism_Homo sapiens_hsa004100.47150494
149Biosynthesis of amino acids_Homo sapiens_hsa012300.46432217
150Nicotine addiction_Homo sapiens_hsa050330.45588359
151Circadian entrainment_Homo sapiens_hsa047130.44163343
152Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43874235
153Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43713584
154Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43601758
155Melanoma_Homo sapiens_hsa052180.43225071
156Amphetamine addiction_Homo sapiens_hsa050310.43203347
157Renal cell carcinoma_Homo sapiens_hsa052110.42956356
158GnRH signaling pathway_Homo sapiens_hsa049120.41840043
159Morphine addiction_Homo sapiens_hsa050320.41089797
160Fatty acid elongation_Homo sapiens_hsa000620.40847785
161DNA replication_Homo sapiens_hsa030300.40705313
162Glutamatergic synapse_Homo sapiens_hsa047240.39813531
163Taste transduction_Homo sapiens_hsa047420.38215160
164Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37841309
165Long-term depression_Homo sapiens_hsa047300.34543890

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