LAMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycosphingolipid catabolic process (GO:0046479)4.29730694
2oligosaccharide catabolic process (GO:0009313)4.03748008
3low-density lipoprotein particle clearance (GO:0034383)3.96487233
4glycolipid catabolic process (GO:0019377)3.85693044
5barbed-end actin filament capping (GO:0051016)3.80269791
6cellular response to thyroid hormone stimulus (GO:0097067)3.68742368
7protein localization to endosome (GO:0036010)3.68645337
8apoptotic cell clearance (GO:0043277)3.62052809
9response to lipoprotein particle (GO:0055094)3.59476130
10positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.54616147
11positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.49794652
12virion attachment to host cell (GO:0019062)3.46296290
13adhesion of symbiont to host cell (GO:0044650)3.46296290
14alpha-linolenic acid metabolic process (GO:0036109)3.45554754
15ceramide catabolic process (GO:0046514)3.28646425
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.28250745
17L-phenylalanine catabolic process (GO:0006559)3.28250745
18regulation of mononuclear cell migration (GO:0071675)3.20945205
19response to thyroid hormone (GO:0097066)3.18573960
20adhesion of symbiont to host (GO:0044406)3.13589828
21pinocytosis (GO:0006907)3.12593734
22L-phenylalanine metabolic process (GO:0006558)3.11532789
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.11532789
24plasma lipoprotein particle clearance (GO:0034381)3.09908248
25axon ensheathment in central nervous system (GO:0032291)3.09470687
26central nervous system myelination (GO:0022010)3.09470687
27response to peptidoglycan (GO:0032494)3.08884818
28cell adhesion mediated by integrin (GO:0033627)3.06392434
29regulation of membrane protein ectodomain proteolysis (GO:0051043)3.03211457
30myelin maintenance (GO:0043217)3.02821289
31hyaluronan catabolic process (GO:0030214)3.01363691
32amino sugar catabolic process (GO:0046348)3.00412940
33negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.99994459
34positive regulation of extracellular matrix organization (GO:1903055)2.98182500
35regulation of cholesterol storage (GO:0010885)2.98131771
36creatine metabolic process (GO:0006600)2.96563625
37negative regulation of erythrocyte differentiation (GO:0045647)2.95565426
38positive regulation by symbiont of host defense response (GO:0052509)2.92481890
39modulation by symbiont of host defense response (GO:0052031)2.92481890
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.92481890
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.92481890
42positive regulation by organism of defense response of other organism involved in symbiotic interact2.92481890
43modulation by symbiont of host immune response (GO:0052553)2.92481890
44membrane lipid catabolic process (GO:0046466)2.92443704
45hemidesmosome assembly (GO:0031581)2.89461762
46endodermal cell differentiation (GO:0035987)2.88799747
47negative regulation of interleukin-12 production (GO:0032695)2.88759106
48regulation of vitamin D biosynthetic process (GO:0060556)2.86676749
49cysteine metabolic process (GO:0006534)2.85168837
50lipopolysaccharide-mediated signaling pathway (GO:0031663)2.84874495
51sphingolipid catabolic process (GO:0030149)2.83101562
52peptidyl-glutamic acid carboxylation (GO:0017187)2.81883591
53protein carboxylation (GO:0018214)2.81883591
54macroautophagy (GO:0016236)2.79990845
55fatty acid elongation (GO:0030497)2.78568251
56mannose metabolic process (GO:0006013)2.77082245
57long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.77016390
58regulation of interferon-beta biosynthetic process (GO:0045357)2.73826812
59dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.73730929
60COPI coating of Golgi vesicle (GO:0048205)2.73401811
61Golgi transport vesicle coating (GO:0048200)2.73401811
62regulation of cholesterol homeostasis (GO:2000188)2.69672036
63fatty-acyl-CoA biosynthetic process (GO:0046949)2.68962292
64fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.67798071
65amyloid precursor protein catabolic process (GO:0042987)2.67388967
66regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.66865553
67regulation of macrophage chemotaxis (GO:0010758)2.63323541
68decidualization (GO:0046697)2.63083576
69glial cell migration (GO:0008347)2.62974728
70sulfur amino acid catabolic process (GO:0000098)2.62889119
71positive regulation of cholesterol efflux (GO:0010875)2.62198553
72import into cell (GO:0098657)2.60967984
73positive regulation of cellular amide metabolic process (GO:0034250)2.60771071
74negative regulation of response to reactive oxygen species (GO:1901032)2.59690664
75positive regulation of p38MAPK cascade (GO:1900745)2.58909300
76response to methylmercury (GO:0051597)2.58827136
77negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.57885044
78detection of molecule of bacterial origin (GO:0032490)2.57140435
794-hydroxyproline metabolic process (GO:0019471)2.55411771
80negative regulation of nitric oxide biosynthetic process (GO:0045019)2.55173345
81regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.55040077
82response to mercury ion (GO:0046689)2.53181552
83glycosylceramide metabolic process (GO:0006677)2.52918769
84regulation of lipoprotein metabolic process (GO:0050746)2.52416590
85protein retention in ER lumen (GO:0006621)2.52022637
86keratan sulfate catabolic process (GO:0042340)2.51779148
87regulation of extracellular matrix disassembly (GO:0010715)2.50521184
88peptide catabolic process (GO:0043171)2.50294031
89L-alpha-amino acid transmembrane transport (GO:1902475)2.50193248
90positive regulation of receptor recycling (GO:0001921)2.49803173
91maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.49297494
92regulation of early endosome to late endosome transport (GO:2000641)2.48986764
93surfactant homeostasis (GO:0043129)2.47934777
94epithelial cell-cell adhesion (GO:0090136)2.46961952
95amyloid precursor protein metabolic process (GO:0042982)2.46908288
96very long-chain fatty acid metabolic process (GO:0000038)2.46704456
97acyl-CoA biosynthetic process (GO:0071616)2.46147102
98thioester biosynthetic process (GO:0035384)2.46147102
99substrate-dependent cell migration (GO:0006929)2.44323577
100glyoxylate metabolic process (GO:0046487)2.43963250
101cellular response to vitamin (GO:0071295)2.43659874
102regulation of vitamin metabolic process (GO:0030656)2.43462047
103axon ensheathment (GO:0008366)2.43298256
104ensheathment of neurons (GO:0007272)2.43298256
105cortical actin cytoskeleton organization (GO:0030866)2.43238156
106cell-substrate junction assembly (GO:0007044)2.40990740
107regulation of cholesterol biosynthetic process (GO:0045540)2.40618810
108basement membrane organization (GO:0071711)2.40215201
109triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.40190130
110positive regulation of endothelial cell apoptotic process (GO:2000353)2.40058143
111regulation of podosome assembly (GO:0071801)2.39845250
112lysine metabolic process (GO:0006553)2.39723790
113lysine catabolic process (GO:0006554)2.39723790
114regulation of hydrogen peroxide-induced cell death (GO:1903205)2.38841314
115collagen metabolic process (GO:0032963)2.38804369
116membrane protein ectodomain proteolysis (GO:0006509)2.38534100
117cellular modified amino acid catabolic process (GO:0042219)2.37569292
118regulation of monocyte chemotaxis (GO:0090025)2.37183973
119collagen catabolic process (GO:0030574)2.36941685
120positive regulation of chemokine biosynthetic process (GO:0045080)2.36854574
121NADPH regeneration (GO:0006740)2.35960827
122regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.35471738
123response to laminar fluid shear stress (GO:0034616)2.35187812
124positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.34175772
125myelination (GO:0042552)2.34116001
126aspartate family amino acid catabolic process (GO:0009068)2.33788003
127positive regulation of osteoblast proliferation (GO:0033690)2.32949647
128negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.31136031
129pentose-phosphate shunt (GO:0006098)2.30629414
130skin morphogenesis (GO:0043589)2.30001428
131myeloid dendritic cell differentiation (GO:0043011)2.29404212
132hypotonic response (GO:0006971)2.29112515
133positive regulation of monocyte chemotaxis (GO:0090026)2.28653892
134N-acetylneuraminate metabolic process (GO:0006054)2.28549272
135regulation of cholesterol metabolic process (GO:0090181)2.28244970
136activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.28180290
137regulation of extracellular matrix organization (GO:1903053)2.27868685
138drug transmembrane transport (GO:0006855)2.27741603
139stress fiber assembly (GO:0043149)2.27013494
140growth hormone receptor signaling pathway (GO:0060396)2.25836428
141extracellular matrix disassembly (GO:0022617)2.25223018
142endocytic recycling (GO:0032456)2.25172604
143acetyl-CoA metabolic process (GO:0006084)2.24521581
144fatty acid beta-oxidation (GO:0006635)2.23755617
145multicellular organismal macromolecule metabolic process (GO:0044259)2.22262702
146vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.22165369
147fatty-acyl-CoA metabolic process (GO:0035337)2.21896005
148positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.20645858
149macrophage activation involved in immune response (GO:0002281)2.20321154
150protein-lipid complex assembly (GO:0065005)2.20203533
151NIK/NF-kappaB signaling (GO:0038061)2.20175137
152multicellular organismal catabolic process (GO:0044243)2.20011098
153T-helper 1 type immune response (GO:0042088)2.18742541
154epithelial cell differentiation involved in prostate gland development (GO:0060742)2.18723788
155regulation of T-helper 2 cell differentiation (GO:0045628)2.18251546
156embryo implantation (GO:0007566)2.18236205
157response to muramyl dipeptide (GO:0032495)2.18229878
158semaphorin-plexin signaling pathway (GO:0071526)2.17828477
159cholesterol metabolic process (GO:0008203)2.17192951
160negative regulation of protein localization to plasma membrane (GO:1903077)2.17046746
161cytoskeletal anchoring at plasma membrane (GO:0007016)2.16743398
162complement activation, alternative pathway (GO:0006957)2.16528166
163positive regulation of cholesterol transport (GO:0032376)2.16485487
164positive regulation of sterol transport (GO:0032373)2.16485487
165fatty acid oxidation (GO:0019395)2.16229999
166lipid oxidation (GO:0034440)2.15833688
167heme transport (GO:0015886)2.15766320
168cellular copper ion homeostasis (GO:0006878)2.15716104
169cortical cytoskeleton organization (GO:0030865)2.15496062
170ethanol oxidation (GO:0006069)2.15215888
171positive regulation of phagocytosis (GO:0050766)2.14783392
172modulation by symbiont of host cellular process (GO:0044068)2.14297912
173response to progesterone (GO:0032570)2.13948700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.50382940
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.45600217
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.42981282
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.12112653
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.06115252
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.00235655
7CLOCK_20551151_ChIP-Seq_293T_Human2.80978699
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.78755934
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.50238359
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.26379290
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17115001
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.16032214
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07161316
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.07062030
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.03904140
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.02455917
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.95771528
18VDR_21846776_ChIP-Seq_THP-1_Human1.95695330
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89004971
20SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.88549202
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.86674541
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86236150
23* IRF8_27001747_Chip-Seq_BMDM_Mouse1.77465868
24CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.74828194
25* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73906101
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.69717719
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69020271
28* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68748139
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67850169
30VDR_24763502_ChIP-Seq_THP-1_Human1.65694852
31SOX2_27498859_Chip-Seq_STOMACH_Mouse1.65316727
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.64887537
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.63280559
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.61936245
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.61936245
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.60100744
37TCF7_22412390_ChIP-Seq_EML_Mouse1.57780860
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56091407
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55564613
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53294690
41SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51844480
42* IRF8_21731497_ChIP-ChIP_J774_Mouse1.51677739
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48507944
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47185403
45FOXA2_19822575_ChIP-Seq_HepG2_Human1.40515831
46GATA1_19941826_ChIP-Seq_K562_Human1.38997852
47RACK7_27058665_Chip-Seq_MCF-7_Human1.37882118
48SOX2_20726797_ChIP-Seq_SW620_Human1.37858298
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36506907
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35297823
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34802459
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.33481333
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.32644585
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31226118
55CJUN_26792858_Chip-Seq_BT549_Human1.30941060
56LXR_22292898_ChIP-Seq_THP-1_Human1.28943541
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28255551
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27463924
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.27435173
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.27253947
61MYC_22102868_ChIP-Seq_BL_Human1.25210277
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22653114
63ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21288278
64TBX20_22080862_ChIP-Seq_HEART_Mouse1.20428167
65TBX20_22328084_ChIP-Seq_HEART_Mouse1.20428167
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20268959
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19079837
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17932457
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17576326
70* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16791709
71* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16621561
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15616680
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15154360
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14467455
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13910550
76TP53_22127205_ChIP-Seq_IMR90_Human1.12303207
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.12280065
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12270119
79JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12257318
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.11934848
81GATA4_25053715_ChIP-Seq_YYC3_Human1.11708565
82JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11335921
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10916214
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10876970
85* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10713843
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09564421
87* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09094000
88ZNF263_19887448_ChIP-Seq_K562_Human1.09061974
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07923646
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07076168
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06485890
92* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05899528
93ATF3_27146783_Chip-Seq_COLON_Human1.05421833
94TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05388011
95SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05337692
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04623432
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04467077
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04148057
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04099634
100* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03667365
101* GATA1_19941827_ChIP-Seq_MEL_Mouse1.03472285
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03469732
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.03119504
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02376189
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01630607
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01468602
107KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01344662
108MAF_26560356_Chip-Seq_TH1_Human1.00302167
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00128381
110SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99623643
111VDR_24787735_ChIP-Seq_THP-1_Human0.98496691
112FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96898593
113PU_27001747_Chip-Seq_BMDM_Mouse0.96497339
114SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96286201
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96220778
116GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96071227
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94558223
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94489510
119GATA2_19941826_ChIP-Seq_K562_Human0.94394848
120* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92616290
121CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92509011
122KDM2B_26808549_Chip-Seq_DND41_Human0.91107348
123HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90951489
124GATA1_22025678_ChIP-Seq_K562_Human0.90460008
125CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89804080
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89237168
127KDM2B_26808549_Chip-Seq_K562_Human0.88914068
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88787720
129GATA6_25053715_ChIP-Seq_YYC3_Human0.88182860
130FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86843310
131SPI1_23127762_ChIP-Seq_K562_Human0.86483178
132UBF1/2_26484160_Chip-Seq_HMECs_Human0.85046694
133SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84595548
134SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84595548
135ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84263848
136* TFEB_21752829_ChIP-Seq_HELA_Human0.83002654
137ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81756203
138* TP63_23658742_ChIP-Seq_EP156T_Human0.81062852

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.23691539
2* MP0005058_abnormal_lysosome_morphology4.04007461
3MP0009840_abnormal_foam_cell3.76401049
4MP0003705_abnormal_hypodermis_morpholog3.06992507
5MP0005360_urolithiasis2.76934552
6MP0003195_calcinosis2.68145271
7MP0002139_abnormal_hepatobiliary_system2.66880150
8MP0003690_abnormal_glial_cell2.61770894
9MP0003172_abnormal_lysosome_physiology2.56776852
10MP0003191_abnormal_cellular_cholesterol2.36731396
11MP0000604_amyloidosis2.35999794
12MP0000920_abnormal_myelination2.32412177
13MP0001958_emphysema2.29668570
14MP0003300_gastrointestinal_ulcer2.11800080
15MP0003329_amyloid_beta_deposits1.99159261
16MP0005275_abnormal_skin_tensile1.93119513
17MP0004510_myositis1.92004948
18MP0005083_abnormal_biliary_tract1.81269935
19MP0003806_abnormal_nucleotide_metabolis1.80904751
20MP0003566_abnormal_cell_adhesion1.70346158
21MP0004185_abnormal_adipocyte_glucose1.70140186
22MP0005365_abnormal_bile_salt1.67492008
23MP0005332_abnormal_amino_acid1.64240021
24MP0006082_CNS_inflammation1.64043111
25MP0008875_abnormal_xenobiotic_pharmacok1.62859273
26MP0000858_altered_metastatic_potential1.61829947
27MP0002148_abnormal_hypersensitivity_rea1.60765581
28MP0004272_abnormal_basement_membrane1.57018305
29MP0003303_peritoneal_inflammation1.56790349
30MP0004043_abnormal_pH_regulation1.54947928
31MP0003252_abnormal_bile_duct1.53848679
32MP0002295_abnormal_pulmonary_circulatio1.51437302
33MP0005623_abnormal_meninges_morphology1.50712799
34MP0003724_increased_susceptibility_to1.50189704
35MP0009643_abnormal_urine_homeostasis1.48866138
36MP0003634_abnormal_glial_cell1.48107980
37MP0005257_abnormal_intraocular_pressure1.46254322
38MP0010329_abnormal_lipoprotein_level1.42065556
39MP0002118_abnormal_lipid_homeostasis1.39571938
40MP0003950_abnormal_plasma_membrane1.37828508
41MP0002877_abnormal_melanocyte_morpholog1.37534020
42MP0004130_abnormal_muscle_cell1.37530802
43MP0008260_abnormal_autophagy1.33789581
44MP0009785_altered_susceptibility_to1.32623787
45MP0005085_abnormal_gallbladder_physiolo1.31958365
46MP0003075_altered_response_to1.26286191
47MP0005025_abnormal_response_to1.26214169
48MP0009384_cardiac_valve_regurgitation1.25097510
49MP0001542_abnormal_bone_strength1.24418527
50MP0000747_muscle_weakness1.24075402
51MP0005076_abnormal_cell_differentiation1.21982846
52MP0005000_abnormal_immune_tolerance1.20906144
53MP0003091_abnormal_cell_migration1.20158324
54MP0003828_pulmonary_edema1.19363814
55MP0003279_aneurysm1.17100423
56MP0001756_abnormal_urination1.17087558
57MP0004858_abnormal_nervous_system1.16969573
58MP0005464_abnormal_platelet_physiology1.16219603
59MP0000685_abnormal_immune_system1.16125884
60MP0000767_abnormal_smooth_muscle1.15360149
61MP0005409_darkened_coat_color1.15103960
62MP0001790_abnormal_immune_system1.14484151
63MP0005387_immune_system_phenotype1.14484151
64MP0001533_abnormal_skeleton_physiology1.13570903
65MP0005666_abnormal_adipose_tissue1.13539339
66MP0002090_abnormal_vision1.13151275
67MP0001853_heart_inflammation1.12773626
68MP0004019_abnormal_vitamin_homeostasis1.12751498
69MP0001666_abnormal_nutrient_absorption1.11491527
70MP0009278_abnormal_bone_marrow1.10360465
71MP0001835_abnormal_antigen_presentation1.10299672
72MP0000609_abnormal_liver_physiology1.08565269
73MP0002168_other_aberrant_phenotype1.08552731
74MP0010234_abnormal_vibrissa_follicle1.08523362
75MP0002896_abnormal_bone_mineralization1.07868539
76MP0002796_impaired_skin_barrier1.07798494
77MP0005375_adipose_tissue_phenotype1.06436842
78MP0005167_abnormal_blood-brain_barrier1.04039131
79MP0005390_skeleton_phenotype1.03093616
80MP0000733_abnormal_muscle_development1.02625085
81MP0002998_abnormal_bone_remodeling1.00222334
82MP0005584_abnormal_enzyme/coenzyme_acti0.99717560
83MP0002254_reproductive_system_inflammat0.99082258
84MP0009764_decreased_sensitivity_to0.98169707
85MP0002138_abnormal_hepatobiliary_system0.97424036
86MP0008004_abnormal_stomach_pH0.97042791
87MP0000013_abnormal_adipose_tissue0.96984358
88MP0000003_abnormal_adipose_tissue0.96275020
89MP0005023_abnormal_wound_healing0.96010335
90MP0003453_abnormal_keratinocyte_physiol0.95165140
91MP0010155_abnormal_intestine_physiology0.95078124
92MP0003656_abnormal_erythrocyte_physiolo0.95055045
93MP0002452_abnormal_antigen_presenting0.94418947
94MP0003186_abnormal_redox_activity0.94322446
95MP0003436_decreased_susceptibility_to0.94081381
96MP0001849_ear_inflammation0.94029113
97MP0009780_abnormal_chondrocyte_physiolo0.93884217
98MP0010678_abnormal_skin_adnexa0.92749718
99MP0001845_abnormal_inflammatory_respons0.91270913
100MP0002136_abnormal_kidney_physiology0.91165126
101MP0003283_abnormal_digestive_organ0.90892685
102MP0001216_abnormal_epidermal_layer0.90370030
103MP0001915_intracranial_hemorrhage0.89379552
104MP0001299_abnormal_eye_distance/0.89302652
105MP0005595_abnormal_vascular_smooth0.89122147
106MP0001243_abnormal_dermal_layer0.89110919
107MP0003045_fibrosis0.88709046
108MP0006054_spinal_hemorrhage0.88532532
109MP0000343_altered_response_to0.87522768
110MP0005319_abnormal_enzyme/_coenzyme0.86518366
111MP0004947_skin_inflammation0.85906055
112MP0004883_abnormal_blood_vessel0.84607514
113MP0002405_respiratory_system_inflammati0.82591156
114MP0002419_abnormal_innate_immunity0.82483472
115MP0004885_abnormal_endolymph0.82238803
116MP0005164_abnormal_response_to0.81451518
117MP0005670_abnormal_white_adipose0.80713480
118MP0005310_abnormal_salivary_gland0.79127511
119MP0002723_abnormal_immune_serum0.78573938
120MP0001851_eye_inflammation0.78571600
121MP0001765_abnormal_ion_homeostasis0.77412054
122MP0003632_abnormal_nervous_system0.77061889
123MP0005503_abnormal_tendon_morphology0.77024854
124MP0010368_abnormal_lymphatic_system0.76100440
125MP0004233_abnormal_muscle_weight0.76033510
126MP0002971_abnormal_brown_adipose0.75703463
127MP0000249_abnormal_blood_vessel0.75133649
128MP0005451_abnormal_body_composition0.74746542
129MP0005508_abnormal_skeleton_morphology0.73263999
130MP0005165_increased_susceptibility_to0.72966322
131MP0001661_extended_life_span0.72914189
132MP0002060_abnormal_skin_morphology0.72818093
133MP0003448_altered_tumor_morphology0.72341468
134MP0001545_abnormal_hematopoietic_system0.70742279
135MP0005397_hematopoietic_system_phenotyp0.70742279
136MP0009333_abnormal_splenocyte_physiolog0.69869499
137MP0000598_abnormal_liver_morphology0.67288492
138MP0008469_abnormal_protein_level0.66804949
139MP0003795_abnormal_bone_structure0.65636941
140MP0010352_gastrointestinal_tract_polyps0.65572063
141MP0005166_decreased_susceptibility_to0.65154670
142MP0002933_joint_inflammation0.64257304
143MP0003183_abnormal_peptide_metabolism0.62578552

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)4.78241265
2Dysostosis multiplex (HP:0000943)4.47104972
3Neurofibrillary tangles (HP:0002185)4.44977328
4Vacuolated lymphocytes (HP:0001922)4.20791043
5Increased neuronal autofluorescent lipopigment (HP:0002074)3.97670314
6Urinary glycosaminoglycan excretion (HP:0003541)3.79915314
7Mucopolysacchariduria (HP:0008155)3.79915314
8Axonal loss (HP:0003447)3.75206403
9Cerebral inclusion bodies (HP:0100314)3.73620550
10Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.54361757
11Premature rupture of membranes (HP:0001788)3.53456739
12Abnormality of mucopolysaccharide metabolism (HP:0011020)3.52209459
13Abnormality of polysaccharide metabolism (HP:0011012)3.52209459
14Abnormality of glycosaminoglycan metabolism (HP:0004371)3.52209459
15Abnormality of liposaccharide metabolism (HP:0010968)3.33286778
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.33286778
17Abnormality of glycolipid metabolism (HP:0010969)3.33286778
18Xanthomatosis (HP:0000991)3.30160295
19Systemic lupus erythematosus (HP:0002725)3.11319995
20Loss of speech (HP:0002371)3.00729201
21Nuclear cataract (HP:0100018)2.90584546
22Supranuclear gaze palsy (HP:0000605)2.66315925
23Complement deficiency (HP:0004431)2.64997504
24Eczematoid dermatitis (HP:0000976)2.63009500
25Myocardial infarction (HP:0001658)2.59953294
26Deep venous thrombosis (HP:0002625)2.59725289
27Atrophic scars (HP:0001075)2.58523812
28Cerebral aneurysm (HP:0004944)2.53243088
29Protrusio acetabuli (HP:0003179)2.51849188
30Peripheral demyelination (HP:0011096)2.48270704
31Global brain atrophy (HP:0002283)2.40781167
32Asymmetric septal hypertrophy (HP:0001670)2.39531442
33Turricephaly (HP:0000262)2.39490801
34Cervical subluxation (HP:0003308)2.39365988
35Abnormality of macrophages (HP:0004311)2.39312964
36Abnormality of aromatic amino acid family metabolism (HP:0004338)2.38971849
37Peritonitis (HP:0002586)2.34928745
38Osteolytic defects of the phalanges of the hand (HP:0009771)2.31954426
39Osteolytic defects of the hand bones (HP:0009699)2.31954426
40Protuberant abdomen (HP:0001538)2.29515669
41Apathy (HP:0000741)2.26631027
42Upper limb amyotrophy (HP:0009129)2.24962436
43Distal upper limb amyotrophy (HP:0007149)2.24962436
44Intrahepatic cholestasis (HP:0001406)2.22872691
45Hypokalemic alkalosis (HP:0001949)2.21473941
46Hyperlipoproteinemia (HP:0010980)2.21231913
47Glomerulonephritis (HP:0000099)2.19546991
48Retinal atrophy (HP:0001105)2.18706115
49Skin nodule (HP:0200036)2.18040022
50Diminished motivation (HP:0000745)2.17758312
51Spondylolisthesis (HP:0003302)2.17017462
52Neuronal loss in central nervous system (HP:0002529)2.16874389
53Increased CSF protein (HP:0002922)2.14920006
54Fragile skin (HP:0001030)2.13473838
55Hypoglycemic coma (HP:0001325)2.12199741
56Shallow orbits (HP:0000586)2.09508361
57Abnormality of complement system (HP:0005339)2.09270495
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.07245581
59Purpura (HP:0000979)2.06152783
60Increased circulating renin level (HP:0000848)2.05117234
61Back pain (HP:0003418)2.02831246
62Broad metatarsal (HP:0001783)2.01191342
63Upper motor neuron abnormality (HP:0002127)2.01097323
64Recurrent bacterial skin infections (HP:0005406)2.01050541
65Bone pain (HP:0002653)2.00734241
66Joint stiffness (HP:0001387)2.00091464
67Abnormality of proline metabolism (HP:0010907)2.00037773
68Hydroxyprolinuria (HP:0003080)2.00037773
69Recurrent abscess formation (HP:0002722)1.99719820
70Disinhibition (HP:0000734)1.99302054
71Wormian bones (HP:0002645)1.99177764
72Ovoid vertebral bodies (HP:0003300)1.98724667
73Hyporeflexia of lower limbs (HP:0002600)1.98543258
74Abnormality of the Achilles tendon (HP:0005109)1.95549868
75Mitral stenosis (HP:0001718)1.94837943
76Ketosis (HP:0001946)1.93934371
77Bladder diverticulum (HP:0000015)1.93086376
78Blue sclerae (HP:0000592)1.93085401
79Genu recurvatum (HP:0002816)1.92320094
80Dilatation of the ascending aorta (HP:0005111)1.92306816
81Ketoacidosis (HP:0001993)1.92117834
82Hand muscle atrophy (HP:0009130)1.91891860
83J-shaped sella turcica (HP:0002680)1.91585410
84Amyloidosis (HP:0011034)1.90980568
85Aortic aneurysm (HP:0004942)1.86804719
86Aneurysm (HP:0002617)1.85756402
87Muscle fiber splitting (HP:0003555)1.85329626
88Spinal rigidity (HP:0003306)1.85200692
89Achilles tendon contracture (HP:0001771)1.84252843
90Vertebral compression fractures (HP:0002953)1.83963394
91Natal tooth (HP:0000695)1.83778063
92Segmental peripheral demyelination/remyelination (HP:0003481)1.83741975
93Stridor (HP:0010307)1.83413801
94Distal lower limb muscle weakness (HP:0009053)1.83299105
95Mutism (HP:0002300)1.83282328
96Clumsiness (HP:0002312)1.83167210
97Progressive neurologic deterioration (HP:0002344)1.83059645
98Hepatosplenomegaly (HP:0001433)1.82972417
99Hypoalphalipoproteinemia (HP:0003233)1.82731295
100Short nail (HP:0001799)1.82586226
101Hyperacusis (HP:0010780)1.82442559
102Cardiovascular calcification (HP:0011915)1.81952398
103Nephritis (HP:0000123)1.81155350
104Ankle contracture (HP:0006466)1.80728047
105Interstitial pulmonary disease (HP:0006530)1.79498383
106Focal segmental glomerulosclerosis (HP:0000097)1.79485159
107Ulnar bowing (HP:0003031)1.78990283
108Vascular tortuosity (HP:0004948)1.78289481
109Aortic dissection (HP:0002647)1.77758211
110Gout (HP:0001997)1.76878602
111Abnormality of purine metabolism (HP:0004352)1.76165772
112Increased connective tissue (HP:0009025)1.75470979
113Recurrent gram-negative bacterial infections (HP:0005420)1.75444281
114Abnormality of the vasculature of the conjunctiva (HP:0008054)1.75159031
115Arterial tortuosity (HP:0005116)1.75147261
116Cardiomegaly (HP:0001640)1.74916988
117Sensorimotor neuropathy (HP:0007141)1.74649278
118Spastic tetraparesis (HP:0001285)1.74274203
119Distal lower limb amyotrophy (HP:0008944)1.72468420
120Abnormality of the lumbar spine (HP:0100712)1.71781461
121Hyperparathyroidism (HP:0000843)1.70706578
122Onion bulb formation (HP:0003383)1.69823781
123Pathologic fracture (HP:0002756)1.69535154
124Vascular calcification (HP:0004934)1.69274871
125Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69254757
126Degeneration of the lateral corticospinal tracts (HP:0002314)1.69254757
127Mitral regurgitation (HP:0001653)1.69113510
128Tetraparesis (HP:0002273)1.68663764
129Malnutrition (HP:0004395)1.67961997
130Epidermoid cyst (HP:0200040)1.67844606
131Abnormality of serine family amino acid metabolism (HP:0010894)1.67135914
132Abnormality of glycine metabolism (HP:0010895)1.67135914
133Beaking of vertebral bodies (HP:0004568)1.66804570
134Thoracic kyphosis (HP:0002942)1.66569248
135Gingivitis (HP:0000230)1.65592284
136Thin bony cortex (HP:0002753)1.65201411
137Prolonged neonatal jaundice (HP:0006579)1.64913572
138Dementia (HP:0000726)1.62209209
139Flat acetabular roof (HP:0003180)1.59663984
140Increased variability in muscle fiber diameter (HP:0003557)1.59152317
141Abnormality of the thoracic spine (HP:0100711)1.57714530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.74136220
2IRAK33.65942689
3EPHB13.56923717
4ERN13.20610104
5STK392.90518567
6PRPF4B2.83765992
7WNK42.49549030
8MET2.45229121
9TTN2.36744116
10NME22.21303348
11OXSR12.06931194
12PKN21.89648364
13SCYL21.86072292
14TAOK21.85260669
15MAP3K141.81094196
16SIK11.81003503
17RIPK11.76660482
18DDR21.70816895
19NTRK11.70568155
20BMX1.68783776
21PTK61.67480293
22LATS21.62117308
23SMG11.59186205
24CAMK1D1.58546921
25PDGFRA1.56241535
26LRRK21.55834008
27CDC42BPA1.54830387
28BCKDK1.49611246
29KSR21.48317589
30GRK71.45074262
31PTK21.43147062
32MAP3K21.41770122
33MAP3K131.40424020
34PBK1.35612977
35MAP3K111.34673351
36WNK11.32498020
37ICK1.32211348
38EPHB21.29352209
39CAMK1G1.28350980
40TGFBR21.24586551
41TAOK11.22907212
42CDK121.20070345
43ARAF1.20043630
44FGFR41.19779884
45TBK11.18965569
46ZAP701.18051545
47PIM21.17420218
48LIMK11.16965368
49FGFR21.12035180
50PAK31.11271123
51MST1R1.07779404
52PAK41.07660861
53EEF2K1.07523344
54TESK11.05427322
55TAOK31.04803048
56TESK21.01400222
57RPS6KA21.00417826
58PAK20.95085963
59BLK0.93665980
60FGR0.93317666
61PDGFRB0.92107568
62PDPK10.91549649
63RET0.91330034
64IRAK40.90933642
65MAPK150.90784701
66PAK60.90146552
67MATK0.90033453
68LATS10.88097582
69PRKD10.87954980
70ABL20.85558032
71PRKD20.84619993
72GSK3A0.83043425
73MAP2K20.82322482
74JAK10.82217109
75JAK30.81613049
76TYK20.81300513
77NEK90.80645051
78MAP3K30.79956532
79PRKD30.79804066
80MOS0.78190665
81MAP3K60.75432949
82CSK0.74887128
83RIPK40.74698757
84PKN10.74437460
85ROCK20.74027982
86MAPKAPK50.73837709
87DYRK1B0.73705748
88FER0.72727277
89PRKG20.72718609
90MAP3K10.72203248
91DMPK0.71426595
92MYLK0.71287257
93EPHA30.69932081
94TRPM70.69710686
95RPS6KL10.69245735
96RPS6KC10.69245735
97ERBB40.68874626
98WNK30.67739771
99PDK20.67590217
100EPHA20.67580319
101INSRR0.67433946
102IRAK20.67400414
103STK100.66410952
104JAK20.66259759
105MARK20.64777886
106PRKCH0.64580270
107MTOR0.64101020
108TYRO30.63023636
109CAMKK20.62256260
110LMTK20.61111476
111EGFR0.61051524
112CSF1R0.57196986
113IKBKB0.55334582
114STK30.54847732
115CSNK1A1L0.54599468
116PDK30.54456967
117PDK40.54456967
118MAP2K10.54173627
119PIK3CG0.54148963
120MAPK70.53293994
121MAP2K30.51865828
122CAMKK10.51557142
123PTK2B0.50947730
124KIT0.48027986
125FGFR30.47031795
126RPS6KA60.45147898
127INSR0.44468043
128PHKG20.44265905
129PHKG10.44265905
130STK380.43146452
131CHUK0.42701181
132PDK10.41905611
133FYN0.40707940
134DAPK30.40207746
135CDK60.40020819
136MAP3K80.39930383
137HIPK20.39850696
138SRC0.39415569
139IKBKE0.36396554
140MAP4K10.35545927
141SGK30.35303086
142MAP3K90.34641891
143MAPK40.34436871
144MAPK120.33249113
145MAPKAPK20.32701488

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.54535852
2* Lysosome_Homo sapiens_hsa041422.80620264
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.52477977
4Steroid biosynthesis_Homo sapiens_hsa001002.40807100
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.23854791
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.09832592
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89191822
8Other glycan degradation_Homo sapiens_hsa005111.88579307
9Fatty acid degradation_Homo sapiens_hsa000711.83499785
10Staphylococcus aureus infection_Homo sapiens_hsa051501.83455093
11Fatty acid metabolism_Homo sapiens_hsa012121.75611358
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74362870
13Fatty acid elongation_Homo sapiens_hsa000621.70548954
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68370426
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.68246140
16Sulfur metabolism_Homo sapiens_hsa009201.68138768
17Butanoate metabolism_Homo sapiens_hsa006501.60878182
18PPAR signaling pathway_Homo sapiens_hsa033201.58504915
19Complement and coagulation cascades_Homo sapiens_hsa046101.55659221
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53628148
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52220397
22TNF signaling pathway_Homo sapiens_hsa046681.43707607
23Histidine metabolism_Homo sapiens_hsa003401.41195832
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39744605
25Propanoate metabolism_Homo sapiens_hsa006401.38575066
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36790217
27Tryptophan metabolism_Homo sapiens_hsa003801.36289540
28Toxoplasmosis_Homo sapiens_hsa051451.34194649
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33988361
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33248137
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32788459
32Arginine biosynthesis_Homo sapiens_hsa002201.30771793
33Caffeine metabolism_Homo sapiens_hsa002321.24688330
34Bile secretion_Homo sapiens_hsa049761.23259250
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20529663
36Peroxisome_Homo sapiens_hsa041461.20141807
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17161066
38Chronic myeloid leukemia_Homo sapiens_hsa052201.11040140
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.10527633
40Acute myeloid leukemia_Homo sapiens_hsa052211.08972881
41VEGF signaling pathway_Homo sapiens_hsa043701.03957999
42Galactose metabolism_Homo sapiens_hsa000521.02513635
43* Phagosome_Homo sapiens_hsa041451.01163207
44Hepatitis C_Homo sapiens_hsa051600.99273070
45B cell receptor signaling pathway_Homo sapiens_hsa046620.98830699
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98821253
47Sphingolipid metabolism_Homo sapiens_hsa006000.96973802
48ECM-receptor interaction_Homo sapiens_hsa045120.96542598
49Shigellosis_Homo sapiens_hsa051310.96381793
50Prion diseases_Homo sapiens_hsa050200.95920886
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94074428
52Influenza A_Homo sapiens_hsa051640.92247386
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91838423
54Pancreatic cancer_Homo sapiens_hsa052120.91150726
55Mineral absorption_Homo sapiens_hsa049780.91071226
56Legionellosis_Homo sapiens_hsa051340.90093335
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89730141
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89456986
59Fat digestion and absorption_Homo sapiens_hsa049750.89392164
60Arginine and proline metabolism_Homo sapiens_hsa003300.89256624
61Amoebiasis_Homo sapiens_hsa051460.87715975
62Notch signaling pathway_Homo sapiens_hsa043300.87320723
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87159538
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86897714
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.86297589
66Apoptosis_Homo sapiens_hsa042100.85455828
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.85380578
68Pyruvate metabolism_Homo sapiens_hsa006200.83892013
69Starch and sucrose metabolism_Homo sapiens_hsa005000.83436825
70Selenocompound metabolism_Homo sapiens_hsa004500.83147885
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82903189
72Fatty acid biosynthesis_Homo sapiens_hsa000610.82224239
73beta-Alanine metabolism_Homo sapiens_hsa004100.81646930
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.80226992
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80218098
76Small cell lung cancer_Homo sapiens_hsa052220.79731908
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77837358
78Hepatitis B_Homo sapiens_hsa051610.77426677
79Carbon metabolism_Homo sapiens_hsa012000.75138816
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.75120400
81Glycerolipid metabolism_Homo sapiens_hsa005610.73703707
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73608874
83Focal adhesion_Homo sapiens_hsa045100.73167929
84ABC transporters_Homo sapiens_hsa020100.73025296
85Prolactin signaling pathway_Homo sapiens_hsa049170.72964477
86Chemical carcinogenesis_Homo sapiens_hsa052040.72893882
87Malaria_Homo sapiens_hsa051440.72378755
88Antigen processing and presentation_Homo sapiens_hsa046120.71316139
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71156701
90Chemokine signaling pathway_Homo sapiens_hsa040620.70847004
91Glutathione metabolism_Homo sapiens_hsa004800.69444769
92Ether lipid metabolism_Homo sapiens_hsa005650.69215762
93GnRH signaling pathway_Homo sapiens_hsa049120.69131510
94Renal cell carcinoma_Homo sapiens_hsa052110.68569663
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67347187
96Endocytosis_Homo sapiens_hsa041440.67029635
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.66877509
98Viral myocarditis_Homo sapiens_hsa054160.66217557
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66179943
100Proteoglycans in cancer_Homo sapiens_hsa052050.65614465
101Allograft rejection_Homo sapiens_hsa053300.65527511
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65418852
103Vitamin B6 metabolism_Homo sapiens_hsa007500.65295256
104Renin-angiotensin system_Homo sapiens_hsa046140.65147359
105Vitamin digestion and absorption_Homo sapiens_hsa049770.65078138
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64636605
107Pertussis_Homo sapiens_hsa051330.64470360
108Vibrio cholerae infection_Homo sapiens_hsa051100.64454141
109Folate biosynthesis_Homo sapiens_hsa007900.63711377
110Non-small cell lung cancer_Homo sapiens_hsa052230.63544158
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.62457477
112African trypanosomiasis_Homo sapiens_hsa051430.62004057
113Fructose and mannose metabolism_Homo sapiens_hsa000510.61979217
114Collecting duct acid secretion_Homo sapiens_hsa049660.59484303
115Hematopoietic cell lineage_Homo sapiens_hsa046400.58008034
116Endometrial cancer_Homo sapiens_hsa052130.57394765
117Protein digestion and absorption_Homo sapiens_hsa049740.56371216
118Insulin resistance_Homo sapiens_hsa049310.56068177
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53596683
120Estrogen signaling pathway_Homo sapiens_hsa049150.53114348
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53099454
122Measles_Homo sapiens_hsa051620.53047159
123HIF-1 signaling pathway_Homo sapiens_hsa040660.52233631
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52203813
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52117748
126Platelet activation_Homo sapiens_hsa046110.51605797
127Glioma_Homo sapiens_hsa052140.51459078
128mTOR signaling pathway_Homo sapiens_hsa041500.50071954
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49995914
130Graft-versus-host disease_Homo sapiens_hsa053320.49803002
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49177113
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.49118370
133Asthma_Homo sapiens_hsa053100.49039426
134Adherens junction_Homo sapiens_hsa045200.48530638
135Rheumatoid arthritis_Homo sapiens_hsa053230.48132788
136Osteoclast differentiation_Homo sapiens_hsa043800.46707008
137Insulin signaling pathway_Homo sapiens_hsa049100.46143218
138Bladder cancer_Homo sapiens_hsa052190.45999776
139ErbB signaling pathway_Homo sapiens_hsa040120.45551858
140MicroRNAs in cancer_Homo sapiens_hsa052060.44942230
141* Tuberculosis_Homo sapiens_hsa051520.44377213
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.44264317
143Prostate cancer_Homo sapiens_hsa052150.44168834
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.43905090
145Phenylalanine metabolism_Homo sapiens_hsa003600.43851018
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42771929
147Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42334510
148Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42116901
149Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42027756
150Biosynthesis of amino acids_Homo sapiens_hsa012300.41775649
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41562103
152Leishmaniasis_Homo sapiens_hsa051400.41230903
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38992652
154Lysine degradation_Homo sapiens_hsa003100.36790652
155Pentose phosphate pathway_Homo sapiens_hsa000300.36465362
156Dorso-ventral axis formation_Homo sapiens_hsa043200.35443914
157Salmonella infection_Homo sapiens_hsa051320.35146034

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