LAMP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.63922195
2L-phenylalanine catabolic process (GO:0006559)4.63922195
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.36833448
4L-phenylalanine metabolic process (GO:0006558)4.36833448
5peptidyl-glutamic acid carboxylation (GO:0017187)4.35630547
6protein carboxylation (GO:0018214)4.35630547
7aromatic amino acid family catabolic process (GO:0009074)4.21952675
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.10660610
9negative regulation of complement activation (GO:0045916)3.91522705
10complement activation, alternative pathway (GO:0006957)3.89581289
11tryptophan metabolic process (GO:0006568)3.80507592
12tryptophan catabolic process (GO:0006569)3.80060361
13indole-containing compound catabolic process (GO:0042436)3.80060361
14indolalkylamine catabolic process (GO:0046218)3.80060361
15alpha-linolenic acid metabolic process (GO:0036109)3.79351562
16glyoxylate metabolic process (GO:0046487)3.79161596
17oligosaccharide catabolic process (GO:0009313)3.78618898
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.77039905
19cell adhesion mediated by integrin (GO:0033627)3.74246614
20negative regulation of protein activation cascade (GO:2000258)3.73658079
21sulfur amino acid catabolic process (GO:0000098)3.73359970
22regulation of protein activation cascade (GO:2000257)3.71811775
23bile acid biosynthetic process (GO:0006699)3.66146875
24cysteine metabolic process (GO:0006534)3.61879339
25regulation of complement activation (GO:0030449)3.61197212
26kynurenine metabolic process (GO:0070189)3.48590552
27negative regulation of fibrinolysis (GO:0051918)3.47906322
28urea metabolic process (GO:0019627)3.45986332
29urea cycle (GO:0000050)3.45986332
30detection of molecule of bacterial origin (GO:0032490)3.45497952
31homocysteine metabolic process (GO:0050667)3.44073094
32iron ion import (GO:0097286)3.42448208
33plasma lipoprotein particle clearance (GO:0034381)3.39618595
34high-density lipoprotein particle remodeling (GO:0034375)3.38841614
35cellular glucuronidation (GO:0052695)3.34676116
36reverse cholesterol transport (GO:0043691)3.29742101
37positive regulation of cellular amide metabolic process (GO:0034250)3.28775922
38amino-acid betaine metabolic process (GO:0006577)3.26625426
39regulation of fibrinolysis (GO:0051917)3.25755757
40glucuronate metabolic process (GO:0019585)3.23261386
41uronic acid metabolic process (GO:0006063)3.23261386
42membrane raft organization (GO:0031579)3.21995593
43phospholipid efflux (GO:0033700)3.21297221
44tyrosine metabolic process (GO:0006570)3.20770714
45glycosphingolipid catabolic process (GO:0046479)3.20107609
46lysine catabolic process (GO:0006554)3.18282279
47lysine metabolic process (GO:0006553)3.18282279
48plasma lipoprotein particle remodeling (GO:0034369)3.18186447
49protein-lipid complex remodeling (GO:0034368)3.18186447
50macromolecular complex remodeling (GO:0034367)3.18186447
51keratan sulfate catabolic process (GO:0042340)3.17378308
52fibrinolysis (GO:0042730)3.17276599
53regulation of triglyceride catabolic process (GO:0010896)3.16204732
54Golgi transport vesicle coating (GO:0048200)3.15836737
55COPI coating of Golgi vesicle (GO:0048205)3.15836737
56nitrogen cycle metabolic process (GO:0071941)3.15474674
57bile acid metabolic process (GO:0008206)3.13486341
58protein localization to endosome (GO:0036010)3.11394449
59drug transmembrane transport (GO:0006855)3.07120518
60urate metabolic process (GO:0046415)3.06581512
61aromatic amino acid family metabolic process (GO:0009072)3.04916309
62regulation of cholesterol esterification (GO:0010872)3.04434381
63negative regulation of humoral immune response (GO:0002921)3.03641351
64valine metabolic process (GO:0006573)3.01851431
65cholesterol efflux (GO:0033344)2.99447415
66macroautophagy (GO:0016236)2.97129411
67aldehyde catabolic process (GO:0046185)2.96014965
68positive regulation of blood coagulation (GO:0030194)2.94094780
69positive regulation of hemostasis (GO:1900048)2.94094780
70phospholipid homeostasis (GO:0055091)2.89557708
71low-density lipoprotein particle remodeling (GO:0034374)2.89161067
72glycolipid catabolic process (GO:0019377)2.87926972
73lipoprotein metabolic process (GO:0042157)2.87755058
74positive regulation of coagulation (GO:0050820)2.87376365
75opsonization (GO:0008228)2.86385180
76positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.84589704
77triglyceride homeostasis (GO:0070328)2.84559769
78acylglycerol homeostasis (GO:0055090)2.84559769
79serine family amino acid catabolic process (GO:0009071)2.82752534
80benzene-containing compound metabolic process (GO:0042537)2.81144993
81COPII vesicle coating (GO:0048208)2.80233845
82bile acid and bile salt transport (GO:0015721)2.77341859
83indolalkylamine metabolic process (GO:0006586)2.77041050
84low-density lipoprotein particle clearance (GO:0034383)2.76560983
85regulation of cholesterol storage (GO:0010885)2.74499858
86response to peptidoglycan (GO:0032494)2.73744926
87positive regulation of lipid catabolic process (GO:0050996)2.72881427
88cellular modified amino acid catabolic process (GO:0042219)2.72626139
89regulation of beta-amyloid formation (GO:1902003)2.71939979
90skin morphogenesis (GO:0043589)2.71606398
91plasma lipoprotein particle assembly (GO:0034377)2.70747530
92response to thyroid hormone (GO:0097066)2.70500617
93complement activation (GO:0006956)2.69236721
94ethanol oxidation (GO:0006069)2.69056265
95negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.68810199
96amine catabolic process (GO:0009310)2.67898463
97cellular biogenic amine catabolic process (GO:0042402)2.67898463
98plasma lipoprotein particle organization (GO:0071827)2.67580149
99alpha-amino acid catabolic process (GO:1901606)2.67523521
100carnitine metabolic process (GO:0009437)2.67511736
101antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.67386142
102response to nitrosative stress (GO:0051409)2.66386178
103fatty acid oxidation (GO:0019395)2.65679652
104lipid oxidation (GO:0034440)2.64649355
105acute-phase response (GO:0006953)2.63758343
106fatty acid beta-oxidation (GO:0006635)2.63349041
107regulation of amyloid precursor protein catabolic process (GO:1902991)2.62781242
108epoxygenase P450 pathway (GO:0019373)2.62517062
109cellular copper ion homeostasis (GO:0006878)2.62314379
110negative regulation of sterol transport (GO:0032372)2.62145532
111negative regulation of cholesterol transport (GO:0032375)2.62145532
112protein-lipid complex subunit organization (GO:0071825)2.62140655
113regulation of cholesterol biosynthetic process (GO:0045540)2.61352185
114protein-lipid complex assembly (GO:0065005)2.61027582
115sterol homeostasis (GO:0055092)2.60729859
116cholesterol homeostasis (GO:0042632)2.60476208
117hemidesmosome assembly (GO:0031581)2.60229901
118positive regulation of lipoprotein lipase activity (GO:0051006)2.59372774
119positive regulation of triglyceride lipase activity (GO:0061365)2.59372774
120complement activation, classical pathway (GO:0006958)2.58264460
121xenobiotic catabolic process (GO:0042178)2.57662632
122negative regulation of response to reactive oxygen species (GO:1901032)2.57113240
123drug transport (GO:0015893)2.56771340
124protein activation cascade (GO:0072376)2.56150843
125positive regulation of fatty acid beta-oxidation (GO:0032000)2.54666021
126regulation of cholesterol metabolic process (GO:0090181)2.54491764
127ceramide catabolic process (GO:0046514)2.53507908
128regulation of integrin-mediated signaling pathway (GO:2001044)2.49343490
129cellular response to thyroid hormone stimulus (GO:0097067)2.48673098
130neutrophil activation involved in immune response (GO:0002283)2.48238097
131positive regulation of macrophage cytokine production (GO:0060907)2.48014450
132regulation of macrophage cytokine production (GO:0010935)2.43797831
133detection of external biotic stimulus (GO:0098581)2.42956946
134macrophage activation involved in immune response (GO:0002281)2.40000482
135positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.38455333
136positive regulation of extracellular matrix organization (GO:1903055)2.35710907
137positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.34231794
138membrane lipid catabolic process (GO:0046466)2.30519102
139sphingolipid catabolic process (GO:0030149)2.30358604
140negative regulation of protein localization to plasma membrane (GO:1903077)2.30083573
141desmosome organization (GO:0002934)2.28657962
142regulation of hydrogen peroxide-induced cell death (GO:1903205)2.27484352
143trivalent inorganic cation transport (GO:0072512)2.26304191
144ferric iron transport (GO:0015682)2.26304191
145maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.26282906
146positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.26003250
147amyloid precursor protein catabolic process (GO:0042987)2.25289818
148macrophage activation (GO:0042116)2.24535367
149import into cell (GO:0098657)2.24525792
150sphingosine metabolic process (GO:0006670)2.22907584
151transferrin transport (GO:0033572)2.22732290
152positive regulation of receptor recycling (GO:0001921)2.21185899
153amino sugar catabolic process (GO:0046348)2.20404677
154positive regulation of actin filament depolymerization (GO:0030836)2.19631851
155negative regulation of interleukin-17 production (GO:0032700)2.19187487
156regulation of cellular amide metabolic process (GO:0034248)2.19157352
157membrane budding (GO:0006900)2.17381264
158vesicle coating (GO:0006901)2.17156361
159amyloid precursor protein metabolic process (GO:0042982)2.15503862
160response to methylmercury (GO:0051597)2.14591831
161lipopolysaccharide-mediated signaling pathway (GO:0031663)2.13621331
162interleukin-6-mediated signaling pathway (GO:0070102)2.12855123
163positive regulation of leukocyte degranulation (GO:0043302)2.12629498
164apoptotic cell clearance (GO:0043277)2.12447898
165regulation of interferon-beta biosynthetic process (GO:0045357)2.12267532
166protein retention in ER lumen (GO:0006621)2.11758118
167regulation of extracellular matrix disassembly (GO:0010715)2.11111447
168membrane protein ectodomain proteolysis (GO:0006509)2.10950370
169cell wall macromolecule catabolic process (GO:0016998)2.10147511
170phagosome maturation (GO:0090382)2.09514022
171positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.09325291
172regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.08710081
173sequestering of metal ion (GO:0051238)2.08699191
174peptide catabolic process (GO:0043171)2.07966068
175regulation of membrane protein ectodomain proteolysis (GO:0051043)2.07702242
176regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.07191342
177detection of other organism (GO:0098543)2.07161489
178copper ion homeostasis (GO:0055070)2.06820619
179chondroitin sulfate catabolic process (GO:0030207)2.05923492
180endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.05183337
181regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.04709281
182regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.03698963
183protein hydroxylation (GO:0018126)2.01840292
184response to manganese ion (GO:0010042)2.01829791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.84505677
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.07684742
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.35987385
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.24512704
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.06237132
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.66155825
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.39894893
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.36555111
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.95866767
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.91677784
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.81965436
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.72731397
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.71122077
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.60284086
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.57689983
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.56493498
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.51100406
18CLOCK_20551151_ChIP-Seq_293T_Human2.40494438
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30575389
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.28784635
21GATA1_22025678_ChIP-Seq_K562_Human2.14545508
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.14050545
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13739295
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.04493303
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02133711
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.01189935
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00628690
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.97248594
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88240654
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88111679
31CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.82343775
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.76749112
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.76749112
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.68251014
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53366915
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53350239
37SOX2_20726797_ChIP-Seq_SW620_Human1.50890217
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50700112
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50248119
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.50198532
41SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49561589
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47668694
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.47337739
44CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.43651043
45* CJUN_26792858_Chip-Seq_BT549_Human1.41627409
46TFEB_21752829_ChIP-Seq_HELA_Human1.37121539
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.33268281
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32228796
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32182626
50SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29706283
51TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.29370263
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28252681
53FOXA2_19822575_ChIP-Seq_HepG2_Human1.26988725
54GATA4_25053715_ChIP-Seq_YYC3_Human1.24330440
55* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.23876823
56* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23740699
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23455449
58TP53_18474530_ChIP-ChIP_U2OS_Human1.21037667
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20729165
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20350061
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18360569
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17858095
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17355592
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16364172
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13081131
66VDR_24787735_ChIP-Seq_THP-1_Human1.12602041
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11022055
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10915599
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.10388001
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09641686
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06009561
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.06000616
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05843598
74PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04486799
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.04188962
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03415060
77SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02493549
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02493549
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02471688
80FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02381763
81SPI1_23127762_ChIP-Seq_K562_Human1.01646433
82TP53_16413492_ChIP-PET_HCT116_Human1.01417612
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.01339693
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01192485
85* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00781645
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00698056
87AHR_22903824_ChIP-Seq_MCF-7_Human0.99996956
88PIAS1_25552417_ChIP-Seq_VCAP_Human0.99686941
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99155203
90CMYC_18555785_Chip-Seq_ESCs_Mouse0.96765593
91ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96121848
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.95777277
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95683994
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95588665
95PU_27001747_Chip-Seq_BMDM_Mouse0.92858392
96P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92855961
97* CDX2_22108803_ChIP-Seq_LS180_Human0.92626236
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92333597
99WT1_19549856_ChIP-ChIP_CCG9911_Human0.90757907
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.90492795
101SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90360506
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89049731
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88427561
104HNF4A_19822575_ChIP-Seq_HepG2_Human0.88370913
105* TP63_23658742_ChIP-Seq_EP156T_Human0.86547139
106PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86160305
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85608498
108EGR1_19032775_ChIP-ChIP_M12_Human0.85354387
109CDX2_20551321_ChIP-Seq_CACO-2_Human0.85326278
110STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85113867
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84895670
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84236728
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83355378
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82259895
115FOXA1_25552417_ChIP-Seq_VCAP_Human0.79929663
116GATA2_19941826_ChIP-Seq_K562_Human0.78935828
117* GATA3_24758297_ChIP-Seq_MCF-7_Human0.78859453
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74129961
119CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73198868
120CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73176132
121TBX20_22080862_ChIP-Seq_HEART_Mouse0.72832641
122TBX20_22328084_ChIP-Seq_HEART_Mouse0.72832641
123GATA6_25053715_ChIP-Seq_YYC3_Human0.72647032
124* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72457146
125GATA1_19941826_ChIP-Seq_K562_Human0.70829496
126HIF1A_21447827_ChIP-Seq_MCF-7_Human0.70151524
127BRD4_25478319_ChIP-Seq_HGPS_Human0.69405307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.85414761
2MP0005360_urolithiasis4.59157179
3MP0005365_abnormal_bile_salt3.51482028
4MP0005085_abnormal_gallbladder_physiolo3.49681471
5MP0008438_abnormal_cutaneous_collagen3.09608291
6MP0008875_abnormal_xenobiotic_pharmacok3.07888858
7MP0003252_abnormal_bile_duct2.86971794
8MP0003195_calcinosis2.81480506
9MP0009840_abnormal_foam_cell2.71174581
10MP0010234_abnormal_vibrissa_follicle2.54017225
11MP0005058_abnormal_lysosome_morphology2.48666576
12MP0003191_abnormal_cellular_cholesterol2.38918365
13MP0010329_abnormal_lipoprotein_level2.19451591
14MP0008260_abnormal_autophagy2.08782364
15MP0002138_abnormal_hepatobiliary_system2.07364666
16MP0003806_abnormal_nucleotide_metabolis2.04973900
17MP0003705_abnormal_hypodermis_morpholog1.99056601
18MP0003950_abnormal_plasma_membrane1.98072455
19MP0000569_abnormal_digit_pigmentation1.97424009
20MP0000920_abnormal_myelination1.97083088
21MP0005275_abnormal_skin_tensile1.96012582
22* MP0005332_abnormal_amino_acid1.93310682
23MP0009780_abnormal_chondrocyte_physiolo1.91087155
24MP0004019_abnormal_vitamin_homeostasis1.87495901
25MP0003329_amyloid_beta_deposits1.82025595
26MP0002254_reproductive_system_inflammat1.80864858
27MP0003436_decreased_susceptibility_to1.75208074
28MP0005083_abnormal_biliary_tract1.74421556
29MP0003724_increased_susceptibility_to1.72412763
30MP0003300_gastrointestinal_ulcer1.64177185
31MP0001666_abnormal_nutrient_absorption1.58279112
32MP0006082_CNS_inflammation1.51514446
33MP0003186_abnormal_redox_activity1.50991747
34MP0009643_abnormal_urine_homeostasis1.50971535
35MP0000609_abnormal_liver_physiology1.50430803
36MP0009764_decreased_sensitivity_to1.43900032
37MP0002118_abnormal_lipid_homeostasis1.39600165
38MP0003091_abnormal_cell_migration1.39499182
39MP0005503_abnormal_tendon_morphology1.38517669
40MP0001533_abnormal_skeleton_physiology1.37524830
41MP0005319_abnormal_enzyme/_coenzyme1.34124616
42MP0002419_abnormal_innate_immunity1.34077357
43MP0003183_abnormal_peptide_metabolism1.33800807
44MP0001958_emphysema1.33411374
45MP0001835_abnormal_antigen_presentation1.29849217
46MP0009384_cardiac_valve_regurgitation1.29657274
47MP0003690_abnormal_glial_cell1.25104386
48MP0003279_aneurysm1.24460996
49MP0010352_gastrointestinal_tract_polyps1.23631079
50MP0003828_pulmonary_edema1.21335992
51MP0005165_increased_susceptibility_to1.21143723
52MP0000015_abnormal_ear_pigmentation1.20805402
53MP0003045_fibrosis1.20753875
54MP0010368_abnormal_lymphatic_system1.19745710
55MP0003172_abnormal_lysosome_physiology1.19714431
56MP0002060_abnormal_skin_morphology1.19312809
57MP0008469_abnormal_protein_level1.17738028
58MP0010678_abnormal_skin_adnexa1.17568581
59MP0005171_absent_coat_pigmentation1.16689046
60MP0006054_spinal_hemorrhage1.13175302
61MP0002909_abnormal_adrenal_gland1.12238657
62MP0010386_abnormal_urinary_bladder1.11530770
63MP0003566_abnormal_cell_adhesion1.11143782
64MP0009785_altered_susceptibility_to1.10990833
65MP0000604_amyloidosis1.10521941
66MP0001915_intracranial_hemorrhage1.08175714
67MP0002090_abnormal_vision1.08156737
68MP0004272_abnormal_basement_membrane1.07399392
69MP0005464_abnormal_platelet_physiology1.07257986
70MP0005408_hypopigmentation1.07150797
71MP0000343_altered_response_to1.06545597
72MP0003634_abnormal_glial_cell1.04794211
73MP0002295_abnormal_pulmonary_circulatio1.03665452
74MP0002877_abnormal_melanocyte_morpholog1.03504966
75MP0002148_abnormal_hypersensitivity_rea1.03457256
76MP0002332_abnormal_exercise_endurance1.02997515
77MP0005584_abnormal_enzyme/coenzyme_acti1.02967513
78MP0001756_abnormal_urination1.02648678
79MP0005023_abnormal_wound_healing1.02392812
80MP0004947_skin_inflammation1.02121447
81MP0003633_abnormal_nervous_system1.00281151
82MP0003448_altered_tumor_morphology0.99877537
83MP0002998_abnormal_bone_remodeling0.99713907
84MP0005164_abnormal_response_to0.99215385
85MP0000858_altered_metastatic_potential0.98995486
86MP0002136_abnormal_kidney_physiology0.98967762
87MP0009763_increased_sensitivity_to0.97707629
88MP0000371_diluted_coat_color0.96039472
89MP0003656_abnormal_erythrocyte_physiolo0.95777324
90MP0000598_abnormal_liver_morphology0.95341914
91MP0001851_eye_inflammation0.94636730
92MP0004782_abnormal_surfactant_physiolog0.94116868
93MP0005025_abnormal_response_to0.92780752
94MP0004484_altered_response_of0.92008604
95MP0003075_altered_response_to0.91974796
96MP0001845_abnormal_inflammatory_respons0.90406349
97MP0001542_abnormal_bone_strength0.89621751
98MP0003453_abnormal_keratinocyte_physiol0.88390572
99MP0002168_other_aberrant_phenotype0.87657237
100MP0005390_skeleton_phenotype0.87077649
101MP0001764_abnormal_homeostasis0.85469740
102MP0003632_abnormal_nervous_system0.85454380
103MP0005220_abnormal_exocrine_pancreas0.82440016
104MP0005167_abnormal_blood-brain_barrier0.81671777
105MP0005000_abnormal_immune_tolerance0.80717768
106MP0002896_abnormal_bone_mineralization0.80070506
107MP0003303_peritoneal_inflammation0.79968289
108MP0002928_abnormal_bile_duct0.79935662
109MP0005397_hematopoietic_system_phenotyp0.79436367
110MP0001545_abnormal_hematopoietic_system0.79436367
111MP0000747_muscle_weakness0.78678131
112MP0005387_immune_system_phenotype0.78646430
113MP0001790_abnormal_immune_system0.78646430
114MP0005636_abnormal_mineral_homeostasis0.78640522
115MP0004510_myositis0.77455705
116MP0005174_abnormal_tail_pigmentation0.77212734
117MP0005166_decreased_susceptibility_to0.77003346
118MP0002933_joint_inflammation0.76556912
119MP0001243_abnormal_dermal_layer0.76336655
120MP0000767_abnormal_smooth_muscle0.75475990
121MP0001853_heart_inflammation0.73691738
122MP0005451_abnormal_body_composition0.72797364
123MP0004381_abnormal_hair_follicle0.72724438
124MP0003868_abnormal_feces_composition0.71829509
125MP0005409_darkened_coat_color0.71720487
126MP0004130_abnormal_muscle_cell0.71511872
127MP0009697_abnormal_copulation0.71238814
128MP0002166_altered_tumor_susceptibility0.71217464
129MP0000249_abnormal_blood_vessel0.70554385
130MP0004883_abnormal_blood_vessel0.70351798
131MP0003011_delayed_dark_adaptation0.70150922
132MP0003795_abnormal_bone_structure0.68714574
133MP0005257_abnormal_intraocular_pressure0.68626416
134MP0001661_extended_life_span0.65535166
135* MP0009642_abnormal_blood_homeostasis0.65080755
136MP0000685_abnormal_immune_system0.64059067
137MP0001879_abnormal_lymphatic_vessel0.64000338

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.76919934
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.76919934
3Abnormality of glycolipid metabolism (HP:0010969)5.76919934
4Deep venous thrombosis (HP:0002625)4.54273206
5Xanthomatosis (HP:0000991)4.53678864
6Complement deficiency (HP:0004431)4.38186396
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.37902907
8Intrahepatic cholestasis (HP:0001406)4.36322517
9Systemic lupus erythematosus (HP:0002725)4.22297683
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.03949084
11Prolonged partial thromboplastin time (HP:0003645)3.75804481
12Vacuolated lymphocytes (HP:0001922)3.62673157
13Joint hemorrhage (HP:0005261)3.62431847
14Myocardial infarction (HP:0001658)3.62187504
15Neurofibrillary tangles (HP:0002185)3.57595664
16Abnormality of glutamine family amino acid metabolism (HP:0010902)3.57342591
17Loss of speech (HP:0002371)3.52949926
18Abnormality of complement system (HP:0005339)3.46949253
19Hyperlipoproteinemia (HP:0010980)3.46446012
20Abnormality of the common coagulation pathway (HP:0010990)3.42750477
21Recurrent gram-negative bacterial infections (HP:0005420)3.40230873
22Glomerulonephritis (HP:0000099)3.26998747
23Epidermoid cyst (HP:0200040)2.98407656
24Hypoglycemic coma (HP:0001325)2.95052543
25Increased CSF protein (HP:0002922)2.91651073
26Hypoalphalipoproteinemia (HP:0003233)2.90014989
27Abnormality of the intrinsic pathway (HP:0010989)2.87079868
28Mucopolysacchariduria (HP:0008155)2.84991970
29Urinary glycosaminoglycan excretion (HP:0003541)2.84991970
30Fat malabsorption (HP:0002630)2.84818069
31Axonal loss (HP:0003447)2.82974334
32Dysostosis multiplex (HP:0000943)2.81980632
33Hypobetalipoproteinemia (HP:0003563)2.79471918
34Cerebral inclusion bodies (HP:0100314)2.79456607
35Eczematoid dermatitis (HP:0000976)2.73853072
36Abnormality of proline metabolism (HP:0010907)2.73416480
37Hydroxyprolinuria (HP:0003080)2.73416480
38Increased cerebral lipofuscin (HP:0011813)2.71848696
39Cardiovascular calcification (HP:0011915)2.70811785
40Mitral stenosis (HP:0001718)2.68758321
41Hyperammonemia (HP:0001987)2.68455718
42Hypolipoproteinemia (HP:0010981)2.67970626
43Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.66770311
44Vascular calcification (HP:0004934)2.65673470
45Hypercholesterolemia (HP:0003124)2.65173929
46Abnormality of fatty-acid metabolism (HP:0004359)2.63625118
47Abnormality of sulfur amino acid metabolism (HP:0004339)2.63594314
48Progressive neurologic deterioration (HP:0002344)2.63539928
49Nuclear cataract (HP:0100018)2.63457555
50Hyperglycinuria (HP:0003108)2.60900859
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.59650565
52Abnormality of polysaccharide metabolism (HP:0011012)2.59650565
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.59650565
54Ketosis (HP:0001946)2.59244469
55Abnormality of purine metabolism (HP:0004352)2.57144939
56Increased neuronal autofluorescent lipopigment (HP:0002074)2.55313668
57Nephritis (HP:0000123)2.53640610
58Premature rupture of membranes (HP:0001788)2.53052800
59Cervical subluxation (HP:0003308)2.51952502
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.50232775
61Osteolytic defects of the hand bones (HP:0009699)2.50063735
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.50063735
63Skin nodule (HP:0200036)2.45258383
64Hepatocellular carcinoma (HP:0001402)2.40976993
65Abnormality of glycine metabolism (HP:0010895)2.38716936
66Abnormality of serine family amino acid metabolism (HP:0010894)2.38716936
67Peritonitis (HP:0002586)2.37154529
68Abnormality of nucleobase metabolism (HP:0010932)2.36304349
69Arterial tortuosity (HP:0005116)2.35850514
70Recurrent bacterial skin infections (HP:0005406)2.35395720
71Follicular hyperkeratosis (HP:0007502)2.35241364
72Conjugated hyperbilirubinemia (HP:0002908)2.33489141
73Generalized aminoaciduria (HP:0002909)2.30586111
74Steatorrhea (HP:0002570)2.29728419
75Vascular tortuosity (HP:0004948)2.23812987
76Hyperglycinemia (HP:0002154)2.23053076
77Gout (HP:0001997)2.22854393
78Protrusio acetabuli (HP:0003179)2.22236457
79Ketoacidosis (HP:0001993)2.22139345
80Abnormality of macrophages (HP:0004311)2.21647457
81Esophageal varix (HP:0002040)2.21021955
82Abnormality of methionine metabolism (HP:0010901)2.20147921
83Amyloidosis (HP:0011034)2.20100365
84Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.18410605
85Atrophic scars (HP:0001075)2.12474302
86Recurrent abscess formation (HP:0002722)2.11571201
87Spondylolisthesis (HP:0003302)2.09398519
88Protuberant abdomen (HP:0001538)2.08694406
89Disinhibition (HP:0000734)2.08343845
90Supranuclear gaze palsy (HP:0000605)2.08214097
91Hyporeflexia of lower limbs (HP:0002600)2.07754966
92Gingival bleeding (HP:0000225)2.06758461
93Right ventricular cardiomyopathy (HP:0011663)2.00456563
94Abnormal enzyme/coenzyme activity (HP:0012379)1.99585677
95Postural tremor (HP:0002174)1.99443862
96Asymmetric septal hypertrophy (HP:0001670)1.98773327
97Nausea (HP:0002018)1.97074203
98Prolonged neonatal jaundice (HP:0006579)1.96726384
99Proximal tubulopathy (HP:0000114)1.96469585
100Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96307648
101Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.96082157
102Abnormality of pyrimidine metabolism (HP:0004353)1.94623169
103Global brain atrophy (HP:0002283)1.92412045
104Beaking of vertebral bodies (HP:0004568)1.91994600
105Elevated alkaline phosphatase (HP:0003155)1.90343619
106Vertebral compression fractures (HP:0002953)1.87874799
107Hypoglycemic seizures (HP:0002173)1.87322692
108Pathologic fracture (HP:0002756)1.85050924
109Mutism (HP:0002300)1.84823817
110Hematochezia (HP:0002573)1.84749075
111Abnormality of alkaline phosphatase activity (HP:0004379)1.84083185
112Tetraparesis (HP:0002273)1.83052389
113Pancreatitis (HP:0001733)1.82992441
114Autoamputation (HP:0001218)1.81930740
115Episodic fever (HP:0001954)1.81417944
116Scanning speech (HP:0002168)1.80858401
117Abnormality of the lumbar spine (HP:0100712)1.80760799
118Hyperbilirubinemia (HP:0002904)1.80487478
119Papillary thyroid carcinoma (HP:0002895)1.80234880
120J-shaped sella turcica (HP:0002680)1.79696930
121Apathy (HP:0000741)1.78176875
122Ovoid vertebral bodies (HP:0003300)1.78005824
123Diminished motivation (HP:0000745)1.75268162
124Abnormality of the vasculature of the conjunctiva (HP:0008054)1.73950693
125Patchy hypopigmentation of hair (HP:0011365)1.73818775
126Abnormal cartilage morphology (HP:0002763)1.73653555
127Interstitial pulmonary disease (HP:0006530)1.72976909
128Orchitis (HP:0100796)1.72720804
129Autoimmune thrombocytopenia (HP:0001973)1.72521849
130Action tremor (HP:0002345)1.71642034
131Menorrhagia (HP:0000132)1.70261006
132Purpura (HP:0000979)1.68869227
133Periodontitis (HP:0000704)1.68602505
134Hemorrhage of the eye (HP:0011885)1.67991708
135Thick nail (HP:0001805)1.67622923
136Onycholysis (HP:0001806)1.66587587
137White forelock (HP:0002211)1.66148908
138Alopecia of scalp (HP:0002293)1.66128916
139Albinism (HP:0001022)1.65979630
140* Cardiomegaly (HP:0001640)1.65953871
141Popliteal pterygium (HP:0009756)1.64845087
142Muscle fibrillation (HP:0010546)1.64803172
143Hepatosplenomegaly (HP:0001433)1.64801495
144Lower limb hyperreflexia (HP:0002395)1.63486337
145Cerebral aneurysm (HP:0004944)1.62650486
146Neuronal loss in central nervous system (HP:0002529)1.59580917
147Plantar hyperkeratosis (HP:0007556)1.57570477
148Aortic dissection (HP:0002647)1.57297429
149Hypoplasia of the iris (HP:0007676)1.54069959
150Subacute progressive viral hepatitis (HP:0006572)1.51017384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.65542166
2FGFR42.58857586
3MAP3K122.56919153
4FRK2.51572887
5EPHB12.46978488
6SIK12.43458084
7BCKDK2.31582278
8EIF2AK32.29025502
9MAP3K142.26847601
10TGFBR22.22350038
11TYK22.20361779
12NEK92.18961363
13EPHA32.18128433
14MST1R2.14719888
15TAOK32.13279909
16IRAK31.98459856
17LATS11.93076324
18LIMK11.91711170
19TBK11.84503026
20SIK31.84259565
21BMPR21.82552791
22MOS1.76466314
23ARAF1.75923046
24PBK1.70443947
25TRIB31.67981632
26JAK11.66445638
27PIK3CG1.65933457
28INSRR1.65523504
29TRPM71.60222066
30KSR21.57792193
31TESK11.56565206
32KIT1.52950888
33MET1.51890923
34PTK61.47724982
35MAP3K31.46885352
36EIF2AK11.43635061
37FLT31.42731762
38PLK21.37678714
39MAP3K131.34766738
40GRK71.28501979
41JAK31.28216342
42STK31.23942913
43RIPK11.23195533
44YES11.22230231
45IRAK41.20741404
46WNK41.20676391
47FGFR31.20414131
48KSR11.17769761
49DDR21.16960188
50BLK1.13812387
51IKBKE1.12964057
52PDGFRA1.09738337
53NUAK11.09294560
54ABL21.09036469
55PKN21.08926247
56ERBB41.07140604
57CAMK1D1.05504814
58IKBKB1.05416298
59PIM21.03945327
60JAK21.03651991
61TTN1.02529179
62ROCK21.02374826
63PAK60.99552768
64MAP2K30.98762761
65MAPK150.96905949
66CHUK0.96821468
67PAK30.95767899
68MST40.95192433
69BCR0.92399357
70CDK60.92338827
71FGFR20.90390452
72LATS20.89762258
73CSF1R0.87682107
74PTK20.87340589
75LMTK20.87114404
76RAF10.86758488
77CSK0.85986718
78LRRK20.83118442
79NEK60.82283442
80MAP3K20.78984366
81EPHB20.78919201
82BMX0.78420483
83TRIM280.78269329
84TIE10.76621031
85FER0.73171927
86STK380.72913917
87GSK3A0.72861102
88IRAK10.71238021
89ERBB30.70791309
90ZAP700.70174255
91CAMK2D0.68902218
92BMPR1B0.67474730
93PDGFRB0.65158754
94NTRK10.64854995
95STK38L0.64690402
96DAPK20.64218952
97CAMKK20.62033145
98IGF1R0.61811631
99PRKCE0.61807743
100STK100.60015256
101TEC0.59091560
102ABL10.58736777
103ACVR1B0.58623160
104SGK30.58075281
105RIPK40.57077005
106OXSR10.56156444
107PHKG20.55977977
108PHKG10.55977977
109RPS6KA40.55831223
110STK390.55792193
111MAP2K60.55659492
112TNK20.55527972
113MAPK110.55202393
114PTK2B0.55026550
115DYRK1B0.54521093
116CAMK2G0.53469419
117BTK0.50829305
118ERBB20.50651691
119PIK3CA0.49890008
120WNK30.49701386
121NLK0.49541047
122PRPF4B0.49485948
123FGR0.48789681
124PDPK10.48731504
125EGFR0.48425493
126ITK0.48122478
127ROCK10.47270487
128PRKAA20.47219388
129MAP3K90.46994331
130MAPKAPK20.46807479
131ZAK0.45834870
132KDR0.44101701
133SCYL20.43956171
134MATK0.43471126
135MAP3K10.42918613
136EPHA20.41326505
137PRKCD0.40400573
138TGFBR10.40108992
139LYN0.40103605
140PAK40.39464397
141MAP2K20.39386482
142HCK0.37978772
143MYLK0.37935584
144PDK20.36868988
145PAK20.36851662

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.32025559
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.05280244
3Complement and coagulation cascades_Homo sapiens_hsa046102.78601028
4Staphylococcus aureus infection_Homo sapiens_hsa051502.66297477
5Nitrogen metabolism_Homo sapiens_hsa009102.65425909
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.60006336
7Fatty acid degradation_Homo sapiens_hsa000712.23169647
8Tryptophan metabolism_Homo sapiens_hsa003802.22194079
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14112528
10Arginine biosynthesis_Homo sapiens_hsa002202.02972883
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02777078
12Caffeine metabolism_Homo sapiens_hsa002322.00696532
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97229533
14Peroxisome_Homo sapiens_hsa041461.93602997
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.93428323
16Histidine metabolism_Homo sapiens_hsa003401.89028700
17Sulfur metabolism_Homo sapiens_hsa009201.80212533
18Chemical carcinogenesis_Homo sapiens_hsa052041.78635803
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77769818
20PPAR signaling pathway_Homo sapiens_hsa033201.75807082
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70936674
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68392784
23Vibrio cholerae infection_Homo sapiens_hsa051101.67441196
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.62260851
25Fatty acid metabolism_Homo sapiens_hsa012121.55398910
26Butanoate metabolism_Homo sapiens_hsa006501.54784662
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.53006685
28Starch and sucrose metabolism_Homo sapiens_hsa005001.52737929
29Collecting duct acid secretion_Homo sapiens_hsa049661.50179495
30Steroid biosynthesis_Homo sapiens_hsa001001.48278589
31Propanoate metabolism_Homo sapiens_hsa006401.47977972
32beta-Alanine metabolism_Homo sapiens_hsa004101.47650299
33Retinol metabolism_Homo sapiens_hsa008301.46258183
34* Lysosome_Homo sapiens_hsa041421.43057570
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.26659756
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24949091
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.24898197
38Selenocompound metabolism_Homo sapiens_hsa004501.24560892
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23337223
40Other glycan degradation_Homo sapiens_hsa005111.22825930
41Phenylalanine metabolism_Homo sapiens_hsa003601.20097835
42ABC transporters_Homo sapiens_hsa020101.17749887
43Vitamin digestion and absorption_Homo sapiens_hsa049771.15247038
44Folate biosynthesis_Homo sapiens_hsa007901.14839558
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12614740
46Fatty acid elongation_Homo sapiens_hsa000621.11264849
47Bile secretion_Homo sapiens_hsa049761.08741385
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06119275
49Tyrosine metabolism_Homo sapiens_hsa003501.04564846
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02133380
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94187059
52Salmonella infection_Homo sapiens_hsa051320.91053514
53Malaria_Homo sapiens_hsa051440.90526486
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89299464
55Circadian rhythm_Homo sapiens_hsa047100.88645071
56Glutathione metabolism_Homo sapiens_hsa004800.85251046
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85012952
58Fat digestion and absorption_Homo sapiens_hsa049750.84298130
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81699823
60Arginine and proline metabolism_Homo sapiens_hsa003300.79800650
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79085332
62Shigellosis_Homo sapiens_hsa051310.77258185
63Leishmaniasis_Homo sapiens_hsa051400.76928967
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.76008672
65Pertussis_Homo sapiens_hsa051330.75750059
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72407200
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72342736
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71847669
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71339226
70Dorso-ventral axis formation_Homo sapiens_hsa043200.71166619
71Legionellosis_Homo sapiens_hsa051340.69165301
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67863271
73Pyruvate metabolism_Homo sapiens_hsa006200.66664185
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65045293
75Lysine degradation_Homo sapiens_hsa003100.63586137
76Proteoglycans in cancer_Homo sapiens_hsa052050.63559441
77ECM-receptor interaction_Homo sapiens_hsa045120.62952608
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.61920342
79Endocytosis_Homo sapiens_hsa041440.60534247
80* Phagosome_Homo sapiens_hsa041450.60389937
81Focal adhesion_Homo sapiens_hsa045100.59605610
82Prion diseases_Homo sapiens_hsa050200.58472332
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58366136
84Carbon metabolism_Homo sapiens_hsa012000.57888236
85Amoebiasis_Homo sapiens_hsa051460.57838389
86N-Glycan biosynthesis_Homo sapiens_hsa005100.57802121
87Synaptic vesicle cycle_Homo sapiens_hsa047210.57005168
88Glycerolipid metabolism_Homo sapiens_hsa005610.56904393
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56449674
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55396569
91African trypanosomiasis_Homo sapiens_hsa051430.54078599
92Influenza A_Homo sapiens_hsa051640.53592161
93Renin-angiotensin system_Homo sapiens_hsa046140.52810227
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51853850
95Renal cell carcinoma_Homo sapiens_hsa052110.50514695
96HIF-1 signaling pathway_Homo sapiens_hsa040660.48181876
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47668394
98Insulin resistance_Homo sapiens_hsa049310.47295004
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46740663
100Rheumatoid arthritis_Homo sapiens_hsa053230.46422681
101Osteoclast differentiation_Homo sapiens_hsa043800.46187247
102Measles_Homo sapiens_hsa051620.44967398
103Inositol phosphate metabolism_Homo sapiens_hsa005620.44899246
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44491545
105Pancreatic cancer_Homo sapiens_hsa052120.43972513
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.43672995
107Protein digestion and absorption_Homo sapiens_hsa049740.43467351
108Galactose metabolism_Homo sapiens_hsa000520.42723820
109Fructose and mannose metabolism_Homo sapiens_hsa000510.42418802
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.40960563
111Mineral absorption_Homo sapiens_hsa049780.40758197
112* Tuberculosis_Homo sapiens_hsa051520.40567182
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39975714
114Biosynthesis of amino acids_Homo sapiens_hsa012300.39844467
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.39550531
116Toxoplasmosis_Homo sapiens_hsa051450.38632435
117Platelet activation_Homo sapiens_hsa046110.37824431
118Protein export_Homo sapiens_hsa030600.37701038
119Renin secretion_Homo sapiens_hsa049240.37628377
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.37465144
121Pentose phosphate pathway_Homo sapiens_hsa000300.36926721
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36722351
123Vitamin B6 metabolism_Homo sapiens_hsa007500.36707901
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36390327
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36046286
126Sphingolipid metabolism_Homo sapiens_hsa006000.35732910
127Arachidonic acid metabolism_Homo sapiens_hsa005900.34560102
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34105563
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32870100
130Hepatitis C_Homo sapiens_hsa051600.31297979
131TNF signaling pathway_Homo sapiens_hsa046680.30848500
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30615097
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30380075
134Sulfur relay system_Homo sapiens_hsa041220.28497962
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27905006
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26229621

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