LAMP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pattern specification involved in kidney development (GO:0061004)7.87921896
2cellular response to nitric oxide (GO:0071732)6.71759279
3regulation of T-helper 1 cell differentiation (GO:0045625)6.49836736
4regulation of dendritic cell antigen processing and presentation (GO:0002604)6.33194072
5response to xenobiotic stimulus (GO:0009410)5.96974768
6lung lobe morphogenesis (GO:0060463)5.56418589
7positive regulation of endothelial cell differentiation (GO:0045603)5.56348833
8dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.54640742
9positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003605.53019109
10T-helper 1 type immune response (GO:0042088)5.47849625
11positive regulation of type 2 immune response (GO:0002830)5.44690896
12positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)5.29969872
13positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)5.28845471
14cellular response to reactive nitrogen species (GO:1902170)5.21948773
15positive regulation of T-helper cell differentiation (GO:0045624)5.20777429
16phosphate ion transmembrane transport (GO:0035435)5.08750836
17regulation of endothelial cell differentiation (GO:0045601)5.00883714
18response to nitric oxide (GO:0071731)4.95935273
19respiratory gaseous exchange (GO:0007585)4.88040093
20endothelial tube morphogenesis (GO:0061154)4.87625884
21morphogenesis of an endothelium (GO:0003159)4.87625884
22regulation of phospholipid biosynthetic process (GO:0071071)4.86979794
23positive regulation of antigen processing and presentation (GO:0002579)4.81227994
24trivalent inorganic anion homeostasis (GO:0072506)4.75260647
25phosphate ion homeostasis (GO:0055062)4.75260647
26cellular response to type I interferon (GO:0071357)4.74614474
27type I interferon signaling pathway (GO:0060337)4.74614474
28regulation of chronic inflammatory response (GO:0002676)4.71720980
29regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.71126014
30response to type I interferon (GO:0034340)4.70561063
31sodium-independent organic anion transport (GO:0043252)4.69606308
32positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.68089597
33regulation of T cell tolerance induction (GO:0002664)4.58754149
34cellular anion homeostasis (GO:0030002)4.56023784
35regulation of T-helper cell differentiation (GO:0045622)4.54577758
36regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)4.53171211
37positive regulation of T-helper 1 type immune response (GO:0002827)4.48142766
38positive regulation of interleukin-12 production (GO:0032735)4.47613188
39negative regulation of interleukin-10 production (GO:0032693)4.45782419
40regulation of antigen processing and presentation (GO:0002577)4.43432512
41production of molecular mediator involved in inflammatory response (GO:0002532)4.34639276
42interferon-gamma-mediated signaling pathway (GO:0060333)4.24216346
43positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.18396783
44phosphate ion transport (GO:0006817)4.17597802
45epithelial cell differentiation involved in prostate gland development (GO:0060742)4.17357151
46epithelial tube branching involved in lung morphogenesis (GO:0060441)4.15236601
47positive regulation of tolerance induction (GO:0002645)4.14520172
48regulation of interleukin-12 production (GO:0032655)4.11208487
49regulation of vasculogenesis (GO:2001212)4.09955555
50peptide catabolic process (GO:0043171)4.05740532
51regulation of tolerance induction (GO:0002643)3.99675807
52virion attachment to host cell (GO:0019062)3.99649071
53adhesion of symbiont to host cell (GO:0044650)3.99649071
54regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.98330578
55regulation of interferon-gamma biosynthetic process (GO:0045072)3.97746927
56regulation of T-helper 1 type immune response (GO:0002825)3.95481121
57mesodermal cell differentiation (GO:0048333)3.85905922
58macrophage chemotaxis (GO:0048246)3.85226335
59negative regulation of interleukin-12 production (GO:0032695)3.81707747
60protein localization to endosome (GO:0036010)3.79330191
61negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.78503416
62negative regulation of interleukin-2 production (GO:0032703)3.77694496
63positive regulation of alpha-beta T cell proliferation (GO:0046641)3.76807155
64positive regulation of gamma-delta T cell activation (GO:0046645)3.75412091
65defense response to protozoan (GO:0042832)3.75307052
66NIK/NF-kappaB signaling (GO:0038061)3.73925175
67positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.70373515
68regulation of interferon-alpha production (GO:0032647)3.68005085
69positive regulation of interleukin-10 production (GO:0032733)3.63960075
70regulation of interleukin-10 production (GO:0032653)3.60978003
71regulation of type 2 immune response (GO:0002828)3.60820300
72segment specification (GO:0007379)3.59020607
73lung vasculature development (GO:0060426)3.58214223
74kynurenine metabolic process (GO:0070189)3.58167895
75lung alveolus development (GO:0048286)3.57040575
76establishment of apical/basal cell polarity (GO:0035089)3.54052558
77immunoglobulin mediated immune response (GO:0016064)3.53804020
78regulation of alpha-beta T cell proliferation (GO:0046640)3.52584616
79antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.51172674
80antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.50669644
81response to protozoan (GO:0001562)3.50293943
82positive regulation of defense response to virus by host (GO:0002230)3.48930864
83positive regulation of interferon-alpha production (GO:0032727)3.47074642
84cellular response to interferon-gamma (GO:0071346)3.46152879
85regulation of vitamin D biosynthetic process (GO:0060556)3.44729671
86negative regulation of response to reactive oxygen species (GO:1901032)3.44283402
87blood vessel maturation (GO:0001955)3.43792672
88positive regulation of Cdc42 GTPase activity (GO:0043089)3.42611442
89positive regulation of cAMP-mediated signaling (GO:0043950)3.42193541
90tryptophan catabolic process (GO:0006569)3.40099898
91indole-containing compound catabolic process (GO:0042436)3.40099898
92indolalkylamine catabolic process (GO:0046218)3.40099898
93negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.40051248
94T cell migration (GO:0072678)3.38299669
95antigen processing and presentation of endogenous antigen (GO:0019883)3.37380581
96sphingosine metabolic process (GO:0006670)3.37288495
97positive regulation of NF-kappaB import into nucleus (GO:0042346)3.36249339
98dendritic cell differentiation (GO:0097028)3.36083203
99regulation of interferon-beta biosynthetic process (GO:0045357)3.35571326
100negative regulation of alcohol biosynthetic process (GO:1902931)3.33833079
101response to interferon-gamma (GO:0034341)3.33645478
102regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.32645343
103positive regulation of neutrophil chemotaxis (GO:0090023)3.32426171
104positive regulation of neutrophil migration (GO:1902624)3.32426171
105positive regulation of alpha-beta T cell differentiation (GO:0046638)3.31874628
106adhesion of symbiont to host (GO:0044406)3.31748427
107glomerular epithelial cell development (GO:0072310)3.31324870
108response to peptidoglycan (GO:0032494)3.29666419
109positive regulation of interleukin-17 production (GO:0032740)3.29552308
110hemidesmosome assembly (GO:0031581)3.27392405
111macrophage activation involved in immune response (GO:0002281)3.27107502
112respiratory tube development (GO:0030323)3.26582179
113branch elongation of an epithelium (GO:0060602)3.25499290
114sodium ion homeostasis (GO:0055078)3.25275155
115regulation of interleukin-2 biosynthetic process (GO:0045076)3.24719961
116natural killer cell activation involved in immune response (GO:0002323)3.23746148
117endocardial cushion development (GO:0003197)3.22945839
118regulation of memory T cell differentiation (GO:0043380)3.22887736
119dendritic cell chemotaxis (GO:0002407)3.19924415
120lung secretory cell differentiation (GO:0061140)3.19822985
121germinal center formation (GO:0002467)3.18735301
122negative regulation of fatty acid transport (GO:2000192)3.17749268
123regulation of glomerular filtration (GO:0003093)3.15208346
124myeloid dendritic cell differentiation (GO:0043011)3.14620658
125negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.14329425
126negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.13813473
127negative regulation of cell killing (GO:0031342)3.13813473
128regulation of alpha-beta T cell differentiation (GO:0046637)3.13691395
129response to vitamin A (GO:0033189)3.13315758
130Leydig cell differentiation (GO:0033327)3.13164958
131axis elongation (GO:0003401)3.11977405
132regulation of type I interferon-mediated signaling pathway (GO:0060338)3.09834290
133negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.09375970
134modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.09371093
135positive regulation by organism of defense response of other organism involved in symbiotic interact3.09371093
136modulation by symbiont of host immune response (GO:0052553)3.09371093
137positive regulation by symbiont of host defense response (GO:0052509)3.09371093
138modulation by symbiont of host defense response (GO:0052031)3.09371093
139modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.09371093
140negative regulation of transcription by competitive promoter binding (GO:0010944)3.08630741
141long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.08365189
142response to hyperoxia (GO:0055093)3.07775227
143response to increased oxygen levels (GO:0036296)3.07775227
144lymphangiogenesis (GO:0001946)3.06625501
145regulation of inflammatory response to antigenic stimulus (GO:0002861)3.06559087
146branching involved in salivary gland morphogenesis (GO:0060445)3.05647834
147negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.04493209
148negative regulation of viral genome replication (GO:0045071)3.03514702
149CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.02970847
150response to interleukin-6 (GO:0070741)3.02864442
151sexual reproduction (GO:0019953)3.01829563
152establishment of monopolar cell polarity (GO:0061162)3.01709223
153establishment or maintenance of monopolar cell polarity (GO:0061339)3.01709223
154embryonic foregut morphogenesis (GO:0048617)3.01700222
155cell adhesion mediated by integrin (GO:0033627)3.01567821
156regulation of interleukin-13 production (GO:0032656)3.00424982
157positive regulation of granulocyte chemotaxis (GO:0071624)3.00384772
158glomerular visceral epithelial cell development (GO:0072015)3.00319294
159surfactant homeostasis (GO:0043129)20.1634683
160lipopolysaccharide-mediated signaling pathway (GO:0031663)2.97897070
161regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.95370449
162regulation of hypersensitivity (GO:0002883)2.94942532
163receptor catabolic process (GO:0032801)2.93287374
164lymphocyte chemotaxis (GO:0048247)2.92584729
165negative regulation of interleukin-17 production (GO:0032700)2.92477688
166diol metabolic process (GO:0034311)2.91727666
167regulation of hippo signaling (GO:0035330)2.90996539
168branching involved in labyrinthine layer morphogenesis (GO:0060670)2.90370366
169CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.88933594
170T-helper cell differentiation (GO:0042093)2.88933594
171vascular endothelial growth factor signaling pathway (GO:0038084)2.87541731
172positive regulation of humoral immune response (GO:0002922)2.87045051
173positive regulation of vasculogenesis (GO:2001214)2.86608722
174regulation of alpha-beta T cell activation (GO:0046634)2.86061907
175regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.80457342
176endothelial cell chemotaxis (GO:0035767)2.79102090
177lung-associated mesenchyme development (GO:0060484)2.71546626
178triglyceride biosynthetic process (GO:0019432)2.70993096
179fatty-acyl-CoA biosynthetic process (GO:0046949)2.70808171
180positive regulation of p38MAPK cascade (GO:1900745)2.70148466
181mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.68970032
182hormone catabolic process (GO:0042447)2.67473526
183regulation of integrin-mediated signaling pathway (GO:2001044)2.66991667
184artery development (GO:0060840)2.65302135
185regulation of hydrogen peroxide-induced cell death (GO:1903205)2.61360058
186neutral lipid biosynthetic process (GO:0046460)2.60344487
187acylglycerol biosynthetic process (GO:0046463)2.60344487
188negative regulation of cell fate specification (GO:0009996)2.55850240
189renal system process involved in regulation of blood volume (GO:0001977)2.53508342
190gas transport (GO:0015669)2.52768526
191renal filtration (GO:0097205)2.52149585
192lateral sprouting from an epithelium (GO:0060601)2.51758304
193mesenchymal cell proliferation (GO:0010463)2.50432538
194cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.50052162
195negative regulation of epithelial to mesenchymal transition (GO:0010719)2.49806839
196regulation of cardioblast differentiation (GO:0051890)2.49015877
197chemical homeostasis within a tissue (GO:0048875)16.1695642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.75702444
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.83480846
3GATA1_22025678_ChIP-Seq_K562_Human4.78328479
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.46487987
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.99265469
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.73966019
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.61281961
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.58066745
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01854523
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.94565262
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.79281433
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.78303715
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.75971698
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.75657264
15CLOCK_20551151_ChIP-Seq_293T_Human2.75615123
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73718913
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59662184
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.55518803
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.46161258
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.43931612
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.31541191
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.29730121
23GATA2_21666600_ChIP-Seq_HMVEC_Human2.27970641
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25942590
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.22462273
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18349212
27STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12617770
28RUNX_20019798_ChIP-Seq_JUKART_Human2.12332951
29ESR1_21235772_ChIP-Seq_MCF-7_Human2.12230542
30CDX2_20551321_ChIP-Seq_CACO-2_Human2.07955450
31SOX2_20726797_ChIP-Seq_SW620_Human2.06540881
32EGR1_19374776_ChIP-ChIP_THP-1_Human2.05529268
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.02129770
34AHR_22903824_ChIP-Seq_MCF-7_Human2.01577148
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98639040
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98057654
37VDR_24787735_ChIP-Seq_THP-1_Human1.88307629
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.86981269
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.85743251
40MYB_26560356_Chip-Seq_TH2_Human1.83446901
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.71814986
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.67548732
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.64587896
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64039323
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63403188
46RACK7_27058665_Chip-Seq_MCF-7_Human1.61759398
47GATA4_25053715_ChIP-Seq_YYC3_Human1.60719196
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60178653
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58533886
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.58391517
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58307626
52TBX20_22328084_ChIP-Seq_HEART_Mouse1.58275721
53TBX20_22080862_ChIP-Seq_HEART_Mouse1.58275721
54MAF_26560356_Chip-Seq_TH1_Human1.58207532
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.55415755
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.54585523
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.54190987
58VDR_24763502_ChIP-Seq_THP-1_Human1.51823760
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50902810
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.50174130
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49284725
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47230892
63ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.45765696
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.45041108
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43282371
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42470352
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42171638
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41740378
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41339815
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.40508975
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40449096
72ZNF263_19887448_ChIP-Seq_K562_Human1.39215886
73CJUN_26792858_Chip-Seq_BT549_Human1.38951513
74ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38926004
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37543507
76* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36917258
77SCL_19346495_ChIP-Seq_HPC-7_Human1.36802885
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34874442
79SPI1_23547873_ChIP-Seq_NB4_Human1.33984299
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33665440
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33471503
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33001090
83* MYB_26560356_Chip-Seq_TH1_Human1.32828387
84TP53_18474530_ChIP-ChIP_U2OS_Human1.29048789
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.28489402
86NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28434685
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28402425
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27923239
89RXR_22158963_ChIP-Seq_LIVER_Mouse1.25291794
90EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24584217
91* GATA3_27048872_Chip-Seq_THYMUS_Human1.23954799
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23683333
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23140932
94PU_27001747_Chip-Seq_BMDM_Mouse1.23071432
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20715291
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20715291
97PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16982521
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16892576
99IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16304663
100SPI1_23127762_ChIP-Seq_K562_Human1.15921847
101* KDM2B_26808549_Chip-Seq_K562_Human1.15512174
102PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15401403
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12431274
104ISL1_27105846_Chip-Seq_CPCs_Mouse1.10429229
105GATA3_26560356_Chip-Seq_TH2_Human1.09654389
106ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09323030
107KLF5_25053715_ChIP-Seq_YYC3_Human1.09164876
108CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08661259
109FOXA2_19822575_ChIP-Seq_HepG2_Human1.08514711
110EGR1_19032775_ChIP-ChIP_M12_Human1.05244679
111RUNX1_22412390_ChIP-Seq_EML_Mouse1.05179842
112TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04535164
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04452987
114GATA1_19941827_ChIP-Seq_MEL_Mouse1.04345725
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04318205
116GATA6_25053715_ChIP-Seq_YYC3_Human1.04308960
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03331785
118TP63_17297297_ChIP-ChIP_HaCaT_Human1.03205825
119MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02953945
120GATA1_19941826_ChIP-Seq_K562_Human1.01241942
121MYC_22102868_ChIP-Seq_BL_Human1.00923750
122SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00766683
123* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99679227
124IRF8_22096565_ChIP-ChIP_GC-B_Human0.99648108
125P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98462889
126GATA3_24758297_ChIP-Seq_MCF-7_Human0.98342190
127ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97121887
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96729278
129LXR_22292898_ChIP-Seq_THP-1_Human0.96536659
130SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96297000
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95193444
132VDR_21846776_ChIP-Seq_THP-1_Human0.94136179
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94016241
134ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91866038
135TCF7_22412390_ChIP-Seq_EML_Mouse0.91774838
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91320436
137SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90319070
138JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89972482
139LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88871681
140* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88483016
141NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88329045
142UBF1/2_26484160_Chip-Seq_HMECs_Human0.88202640
143CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88154330
144UTX_26944678_Chip-Seq_JUKART_Human0.84633081
145PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84494786
146GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83682394
147PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82344823
148MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.81656015
149SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81107041
150VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80004337
151MAF_26560356_Chip-Seq_TH2_Human0.77071590
152FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.76508081
153KDM2B_26808549_Chip-Seq_DND41_Human0.75338164
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75270975
155GATA2_22383799_ChIP-Seq_G1ME_Mouse0.74202948
156KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.73711272
157KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.73711272
158KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.73711272
159SMRT_27268052_Chip-Seq_Bcells_Human0.73330233
160LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73297332
161NOTCH1_21737748_ChIP-Seq_TLL_Human0.72928057
162KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.69894301
163GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69341758
164GATA2_19941826_ChIP-Seq_K562_Human0.67128950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001958_emphysema6.12967943
2MP0008995_early_reproductive_senescence4.89077806
3MP0005083_abnormal_biliary_tract4.34747048
4MP0008004_abnormal_stomach_pH4.10022245
5MP0001835_abnormal_antigen_presentation3.98101037
6MP0002148_abnormal_hypersensitivity_rea3.47596142
7MP0009785_altered_susceptibility_to3.32760772
8MP0001177_atelectasis3.22557079
9MP0003724_increased_susceptibility_to3.16448094
10MP0010368_abnormal_lymphatic_system3.15371642
11MP0005671_abnormal_response_to2.95882701
12MP0005388_respiratory_system_phenotype2.94418112
13MP0002133_abnormal_respiratory_system2.94418112
14MP0005000_abnormal_immune_tolerance2.88727409
15MP0001800_abnormal_humoral_immune2.82758544
16MP0006082_CNS_inflammation2.82116905
17MP0002295_abnormal_pulmonary_circulatio2.79927753
18MP0002138_abnormal_hepatobiliary_system2.76539995
19MP0005025_abnormal_response_to2.70833598
20MP0002452_abnormal_antigen_presenting2.55505354
21MP0002723_abnormal_immune_serum2.55402514
22MP0000566_synostosis2.35783936
23MP0002419_abnormal_innate_immunity2.32247485
24MP0000537_abnormal_urethra_morphology2.31086313
25MP0003191_abnormal_cellular_cholesterol2.19587136
26MP0005167_abnormal_blood-brain_barrier2.15513222
27MP0010155_abnormal_intestine_physiology2.08458641
28MP0001819_abnormal_immune_cell2.03204454
29MP0004782_abnormal_surfactant_physiolog10.7311213
30MP0002420_abnormal_adaptive_immunity1.99579878
31MP0004947_skin_inflammation1.98959555
32MP0010234_abnormal_vibrissa_follicle1.98355363
33MP0001879_abnormal_lymphatic_vessel1.96161784
34MP0001845_abnormal_inflammatory_respons1.87685672
35MP0005310_abnormal_salivary_gland1.74873039
36MP0004510_myositis1.73629650
37MP0005451_abnormal_body_composition1.71311025
38MP0001348_abnormal_lacrimal_gland1.65103596
39MP0001533_abnormal_skeleton_physiology1.64000244
40MP0008469_abnormal_protein_level1.61216087
41MP0000716_abnormal_immune_system1.54759309
42MP0009764_decreased_sensitivity_to1.53258335
43MP0002166_altered_tumor_susceptibility1.52428603
44MP0002132_abnormal_respiratory_system1.51815089
45MP0004272_abnormal_basement_membrane1.51395228
46MP0005058_abnormal_lysosome_morphology1.44437960
47MP0001175_abnormal_lung_morphology1.42665618
48MP0009333_abnormal_splenocyte_physiolog1.36594100
49MP0001853_heart_inflammation1.33688907
50MP0003950_abnormal_plasma_membrane1.31168678
51MP0003115_abnormal_respiratory_system1.31067733
52MP0002998_abnormal_bone_remodeling1.30905623
53MP0002398_abnormal_bone_marrow1.29798282
54MP0001542_abnormal_bone_strength1.26723968
55MP0003786_premature_aging1.22698571
56MP0002006_tumorigenesis1.22583676
57MP0003763_abnormal_thymus_physiology1.22340728
58MP0003566_abnormal_cell_adhesion1.20906221
59MP0008875_abnormal_xenobiotic_pharmacok1.19271069
60MP0001545_abnormal_hematopoietic_system1.16968541
61MP0005397_hematopoietic_system_phenotyp1.16968541
62MP0002429_abnormal_blood_cell1.16783525
63MP0002332_abnormal_exercise_endurance1.16076656
64MP0002163_abnormal_gland_morphology1.11151847
65MP0003690_abnormal_glial_cell1.10559231
66MP0000534_abnormal_ureter_morphology1.09548290
67MP0002277_abnormal_respiratory_mucosa1.09502877
68MP0010678_abnormal_skin_adnexa1.09226013
69MP0009840_abnormal_foam_cell1.09054577
70MP0001851_eye_inflammation1.03582075
71MP0009763_increased_sensitivity_to1.02824529
72MP0003172_abnormal_lysosome_physiology1.02634166
73MP0005085_abnormal_gallbladder_physiolo1.01622023
74MP0005275_abnormal_skin_tensile1.00220474
75MP0003045_fibrosis1.00182040
76MP0010352_gastrointestinal_tract_polyps0.99663458
77MP0004883_abnormal_blood_vessel0.98885640
78MP0005408_hypopigmentation0.97605478
79MP0000689_abnormal_spleen_morphology0.97008880
80MP0002722_abnormal_immune_system0.96547800
81MP0002139_abnormal_hepatobiliary_system0.94055863
82MP0005164_abnormal_response_to0.93693464
83MP0009765_abnormal_xenobiotic_induced0.93629534
84MP0000343_altered_response_to0.93627447
85MP0002098_abnormal_vibrissa_morphology0.90933308
86MP0005166_decreased_susceptibility_to0.89386110
87MP0000858_altered_metastatic_potential0.88403140
88MP0006054_spinal_hemorrhage0.87542073
89MP0000462_abnormal_digestive_system0.87475185
90MP0005023_abnormal_wound_healing0.86272518
91MP0001943_abnormal_respiration0.86173018
92MP0004185_abnormal_adipocyte_glucose0.85597628
93MP0000249_abnormal_blood_vessel0.85515635
94MP0002118_abnormal_lipid_homeostasis0.83615166
95MP0002909_abnormal_adrenal_gland0.82876249
96MP0002254_reproductive_system_inflammat0.82786716
97MP0001666_abnormal_nutrient_absorption0.82424937
98MP0005464_abnormal_platelet_physiology0.82363621
99MP0003656_abnormal_erythrocyte_physiolo0.82113631
100MP0005623_abnormal_meninges_morphology0.81716306
101MP0005595_abnormal_vascular_smooth0.81663053
102MP0000767_abnormal_smooth_muscle0.81519478
103MP0001664_abnormal_digestion0.81312918
104MP0002405_respiratory_system_inflammati0.81026963
105MP0002796_impaired_skin_barrier0.80373005
106MP0000383_abnormal_hair_follicle0.79622507
107MP0003303_peritoneal_inflammation0.79425532
108MP0006138_congestive_heart_failure0.78263723
109MP0001873_stomach_inflammation0.77770312
110MP0000604_amyloidosis0.77727249
111MP0003279_aneurysm0.76220215
112MP0003453_abnormal_keratinocyte_physiol0.74097933
113MP0002234_abnormal_pharynx_morphology0.74006089
114MP0010329_abnormal_lipoprotein_level0.73675654
115MP0000465_gastrointestinal_hemorrhage0.71358986
116MP0003091_abnormal_cell_migration0.69567877
117MP0001346_abnormal_lacrimal_gland0.68291195
118MP0003436_decreased_susceptibility_to0.66327464
119MP0005165_increased_susceptibility_to0.66007996
120MP0003448_altered_tumor_morphology0.64242567
121MP0008874_decreased_physiological_sensi0.63737418
122MP0003705_abnormal_hypodermis_morpholog0.63605405
123MP0009278_abnormal_bone_marrow0.63549123
124MP0004808_abnormal_hematopoietic_stem0.63260381
125MP0003300_gastrointestinal_ulcer0.63239318
126MP0003075_altered_response_to0.61040522
127MP0000627_abnormal_mammary_gland0.60386423
128MP0005390_skeleton_phenotype0.59508137
129MP0003866_abnormal_defecation0.59414214
130MP0003329_amyloid_beta_deposits0.59013796
131MP0000681_abnormal_thyroid_gland0.58211441
132MP0003828_pulmonary_edema0.57431348
133MP0002128_abnormal_blood_circulation0.57335004
134MP0005379_endocrine/exocrine_gland_phen0.56506628
135MP0010030_abnormal_orbit_morphology0.56020870
136MP0001501_abnormal_sleep_pattern0.55957274
137MP0008438_abnormal_cutaneous_collagen0.54516729
138MP0002925_abnormal_cardiovascular_devel0.54324025
139MP0003890_abnormal_embryonic-extraembry0.53514600
140MP0004858_abnormal_nervous_system0.53464327
141MP0000639_abnormal_adrenal_gland0.52893948
142MP0002282_abnormal_trachea_morphology0.52725019
143MP0008961_abnormal_basal_metabolism0.52269383
144MP0005076_abnormal_cell_differentiation0.50653363
145MP0002877_abnormal_melanocyte_morpholog0.50517358
146MP0001614_abnormal_blood_vessel0.50329310
147MP0003119_abnormal_digestive_system0.49761350
148MP0000470_abnormal_stomach_morphology0.49628285
149MP0001849_ear_inflammation0.48809771
150MP0000685_abnormal_immune_system0.48761321
151MP0002168_other_aberrant_phenotype0.48297011
152MP0003638_abnormal_response/metabolism_0.45521481
153MP0004084_abnormal_cardiac_muscle0.45457341
154MP0001790_abnormal_immune_system0.44581611
155MP0005387_immune_system_phenotype0.44581611
156MP0005647_abnormal_sex_gland0.44519235
157MP0009643_abnormal_urine_homeostasis0.44403173
158MP0004130_abnormal_muscle_cell0.44069467
159MP0008260_abnormal_autophagy0.43885796
160MP0002136_abnormal_kidney_physiology0.43017517
161MP0001440_abnormal_grooming_behavior0.41572275

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial fibrosis (HP:0005576)7.02569373
2Tachypnea (HP:0002789)6.98189608
3Respiratory distress (HP:0002098)6.29181876
4Hyperactive renin-angiotensin system (HP:0000841)5.93054625
5Gout (HP:0001997)5.56698587
6Renal salt wasting (HP:0000127)5.43437602
7Chronic bronchitis (HP:0004469)5.08474585
8Neurofibrillary tangles (HP:0002185)4.78655747
9Gastrointestinal infarctions (HP:0005244)4.67232892
10Polycythemia (HP:0001901)4.32444445
11Eczematoid dermatitis (HP:0000976)4.26830471
12Systemic lupus erythematosus (HP:0002725)4.22808459
13Retrobulbar optic neuritis (HP:0100654)4.18682319
14Optic neuritis (HP:0100653)4.18682319
15Onycholysis (HP:0001806)4.07661743
16Tubulointerstitial abnormality (HP:0001969)4.01334761
17Ulnar bowing (HP:0003031)4.00885574
18Vasculitis (HP:0002633)3.95509008
19Orchitis (HP:0100796)3.93697671
20Recurrent bacterial skin infections (HP:0005406)3.88669475
21Tubulointerstitial nephritis (HP:0001970)3.86465903
22Cerebral inclusion bodies (HP:0100314)3.86147218
23Recurrent abscess formation (HP:0002722)3.79569300
24Hypergammaglobulinemia (HP:0010702)3.75849927
25Hemoptysis (HP:0002105)3.71192987
26Mediastinal lymphadenopathy (HP:0100721)3.65055902
27Hematochezia (HP:0002573)3.64856505
28Hyperkalemia (HP:0002153)3.62326047
29Alveolar cell carcinoma (HP:0006519)3.52155912
30Abnormality of glycolipid metabolism (HP:0010969)3.51137125
31Abnormality of liposaccharide metabolism (HP:0010968)3.51137125
32Abnormality of glycosphingolipid metabolism (HP:0004343)3.51137125
33Broad metatarsal (HP:0001783)3.47252393
34Gastrointestinal stroma tumor (HP:0100723)3.46653684
35Myositis (HP:0100614)3.45748477
36Recurrent viral infections (HP:0004429)3.43852193
37Thyroid-stimulating hormone excess (HP:0002925)3.42848462
38Increased IgM level (HP:0003496)3.41481583
39Pulmonary infiltrates (HP:0002113)3.40218995
40Glomerulonephritis (HP:0000099)3.39576060
41Visceral angiomatosis (HP:0100761)3.35951515
42Neoplasm of the tracheobronchial system (HP:0100552)3.31713450
43Chronic otitis media (HP:0000389)3.26904208
44Recurrent bronchitis (HP:0002837)3.26071099
45Abnormality of the nasal mucosa (HP:0000433)3.23007697
46Colitis (HP:0002583)3.21184083
47Keratoconjunctivitis sicca (HP:0001097)3.19727874
48Increased IgE level (HP:0003212)3.17786131
49Recurrent fungal infections (HP:0002841)3.16314019
50Hemangiomatosis (HP:0007461)3.15315541
51Autoimmune thrombocytopenia (HP:0001973)3.14943772
52Gangrene (HP:0100758)3.12800486
53Abnormality of the fingertips (HP:0001211)3.11480731
54Neonatal respiratory distress (HP:0002643)3.07123731
55Recurrent cutaneous fungal infections (HP:0011370)3.06868029
56Chronic mucocutaneous candidiasis (HP:0002728)3.06868029
57Supranuclear gaze palsy (HP:0000605)3.05503130
58Spontaneous hematomas (HP:0007420)2.97320643
59Long toe (HP:0010511)2.96373286
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.95502509
61Tubular atrophy (HP:0000092)2.94481653
62Keratoconjunctivitis (HP:0001096)2.92675461
63Hypertensive crisis (HP:0100735)2.89113977
64IgA deficiency (HP:0002720)2.86735360
65Recurrent skin infections (HP:0001581)2.86375025
66Hypotension (HP:0002615)2.83259700
67Recurrent gram-negative bacterial infections (HP:0005420)2.82224627
68Bowed forearm bones (HP:0003956)2.82173411
69Bowing of the arm (HP:0006488)2.82173411
70Stomach cancer (HP:0012126)2.80800684
71Loss of speech (HP:0002371)2.79631136
72Meningitis (HP:0001287)2.77747662
73Hyperaldosteronism (HP:0000859)2.72498769
74Abnormality of chloride homeostasis (HP:0011422)2.69707026
75Joint swelling (HP:0001386)2.65788219
76Vacuolated lymphocytes (HP:0001922)2.63257033
77Emphysema (HP:0002097)2.62365599
78Amaurosis fugax (HP:0100576)2.60764349
79Chest pain (HP:0100749)2.60060467
80Esophageal varix (HP:0002040)2.59307673
81Autoimmune hemolytic anemia (HP:0001890)2.57940956
82Premature loss of primary teeth (HP:0006323)2.57372302
83Cerebral aneurysm (HP:0004944)2.53628277
84Bronchomalacia (HP:0002780)2.52555260
85Agammaglobulinemia (HP:0004432)2.51067130
86Bronchitis (HP:0012387)2.50575959
87Stenosis of the external auditory canal (HP:0000402)2.47831680
88Dysostosis multiplex (HP:0000943)2.46506551
89Pulmonary fibrosis (HP:0002206)2.46190941
90Abnormality of T cell number (HP:0011839)2.46011266
91Abnormality of the fetal cardiovascular system (HP:0010948)2.44169044
92Abnormal umbilical cord blood vessels (HP:0011403)2.44169044
93Single umbilical artery (HP:0001195)2.44169044
94Inflammation of the large intestine (HP:0002037)2.43719578
95Complement deficiency (HP:0004431)2.43191517
96Increased purine levels (HP:0004368)2.40361461
97Hyperuricemia (HP:0002149)2.40361461
98Megalencephaly (HP:0001355)2.40322887
99Glomerulosclerosis (HP:0000096)2.39568424
100Turricephaly (HP:0000262)2.33820271
101Abnormality of renin-angiotensin system (HP:0000847)2.32934410
102T lymphocytopenia (HP:0005403)2.32473594
103Osteolytic defects of the phalanges of the hand (HP:0009771)2.32041710
104Osteolytic defects of the hand bones (HP:0009699)2.32041710
105Fragile nails (HP:0001808)2.31808724
106Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.31772369
107Subacute progressive viral hepatitis (HP:0006572)2.29471646
108Stomatitis (HP:0010280)2.29280218
109Encephalitis (HP:0002383)2.28961705
110Aplasia involving bones of the extremities (HP:0009825)2.27536617
111Aplasia involving bones of the upper limbs (HP:0009823)2.27536617
112Aplasia of the phalanges of the hand (HP:0009802)2.27536617
113Gastrointestinal inflammation (HP:0004386)2.26650509
114Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.26235989
115Anorexia (HP:0002039)2.24674460
116Arterial thrombosis (HP:0004420)2.22059108
117Nasal polyposis (HP:0100582)2.21064163
118Increased cerebral lipofuscin (HP:0011813)2.20573559
119Malnutrition (HP:0004395)2.19658226
120Arthralgia (HP:0002829)2.19556302
121Nephritis (HP:0000123)2.18843573
122Abnormality of the pleura (HP:0002103)2.18713280
123Humeroradial synostosis (HP:0003041)2.18676175
124Synostosis involving the elbow (HP:0003938)2.18676175
125Recurrent sinusitis (HP:0011108)2.18243281
126Rapidly progressive (HP:0003678)2.17656381
127Pulmonary hypertension (HP:0002092)2.15848600
128Shallow orbits (HP:0000586)2.14008252
129Gingivitis (HP:0000230)2.12388138
130Atrophic scars (HP:0001075)2.12173869
131Abnormality of the endocardium (HP:0004306)2.10438047
132Milia (HP:0001056)2.09815403
133Abnormality of cells of the lymphoid lineage (HP:0012140)2.09699597
134Abnormality of complement system (HP:0005339)2.09640381
135Abnormality of macrophages (HP:0004311)2.08818063
136Lymphopenia (HP:0001888)2.07261560
137Elevated erythrocyte sedimentation rate (HP:0003565)2.06371261
138Xerostomia (HP:0000217)2.06248947
139Partial duplication of thumb phalanx (HP:0009944)2.06189924
140Chronic diarrhea (HP:0002028)2.05948386
141Urticaria (HP:0001025)2.05803377
142Leukocytosis (HP:0001974)2.05448703
143Exertional dyspnea (HP:0002875)2.04919449
144Disinhibition (HP:0000734)2.04881396
145Abnormality of polysaccharide metabolism (HP:0011012)2.04131608
146Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04131608
147Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04131608
148Urinary glycosaminoglycan excretion (HP:0003541)2.03512242
149Mucopolysacchariduria (HP:0008155)2.03512242
150Abnormality of the prostate (HP:0008775)2.02791464
151Pulmonary embolism (HP:0002204)2.02564131
152Decreased circulating renin level (HP:0003351)2.01924206
153Growth hormone excess (HP:0000845)2.01530490
154Interstitial pulmonary disease (HP:0006530)15.2422994
155Split foot (HP:0001839)1.97829935
156Hyponatremia (HP:0002902)1.96692504
157Abnormality of the 2nd finger (HP:0004100)1.95848234
158Broad distal phalanx of finger (HP:0009836)1.92971365
159Conjunctival telangiectasia (HP:0000524)1.88945474
160Abnormality of purine metabolism (HP:0004352)1.88176833
161Thickened helices (HP:0000391)1.85176868
162Prolonged neonatal jaundice (HP:0006579)1.84269896
163Cerebral hemorrhage (HP:0001342)1.81936915
164Deep venous thrombosis (HP:0002625)1.77949942
165Partial duplication of the phalanx of hand (HP:0009999)1.74065501
166Potter facies (HP:0002009)1.71998695
167Facial shape deformation (HP:0011334)1.71998695
168Buphthalmos (HP:0000557)1.71083969
169Abnormality of the phalanges of the 2nd finger (HP:0009541)1.70733771
170Mildly elevated creatine phosphokinase (HP:0008180)1.70204071
171Microcytic anemia (HP:0001935)1.70129725
172Pustule (HP:0200039)1.69838898
173Abnormality of the vasculature of the conjunctiva (HP:0008054)1.67443227
174Overriding aorta (HP:0002623)1.67045457
175Resting tremor (HP:0002322)1.64736070
176Hypokalemic alkalosis (HP:0001949)1.64274642
177Rectal prolapse (HP:0002035)1.60436659
178Adrenal overactivity (HP:0002717)1.59587699
179Plantar hyperkeratosis (HP:0007556)1.59257123
180Cavernous hemangioma (HP:0001048)1.56002922
181Restrictive lung disease (HP:0002091)1.54785380
182Coronal craniosynostosis (HP:0004440)1.53785269
183Progressive sensorineural hearing impairment (HP:0000408)1.53746358
184Abnormality of sodium homeostasis (HP:0010931)1.53390492
185Hyperpituitarism (HP:0010514)1.53311123
186Hypoplasia of dental enamel (HP:0006297)1.53096868
187Premature skin wrinkling (HP:0100678)1.52927353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR25.46894457
2STK244.81039711
3TIE14.65699866
4MAP3K143.98858808
5LRRK23.49217652
6PRPF4B3.23925834
7ZAP702.99917851
8JAK32.99167215
9RIPK42.94810445
10TGFBR22.94482991
11IKBKE2.91359775
12IRAK32.89323193
13GRK72.75192553
14TRIB32.57643667
15PAK42.51947791
16EPHB12.49281623
17EPHA22.42637087
18MAP4K12.39978895
19MST42.31664644
20DAPK22.30984943
21LMTK22.29372046
22RIPK12.28186600
23PDGFRB2.10464499
24ILK2.06721284
25IKBKB2.02304804
26IRAK41.96391633
27KIT1.95742364
28MAP3K131.83223905
29FER1.79229359
30EPHB21.77926880
31FGFR41.76940002
32MST1R1.71653057
33STK101.65440715
34MAPK151.65094011
35IRAK11.54675005
36MAP3K21.50752735
37MAP3K91.45771010
38ERN11.44710901
39PTK61.42951794
40MAP3K31.37292697
41GRK11.35248583
42BMPR21.34549087
43TESK11.32434177
44EPHA31.31251235
45CDK61.25349436
46ADRBK21.18762690
47TAOK31.18402857
48MET1.17659006
49PDGFRA1.15494237
50TXK1.14163440
51KSR21.13113962
52GSK3A1.10474353
53SYK1.10379939
54CAMK1D1.08340312
55SIK11.07819112
56FGFR31.06541029
57MYLK1.05198049
58LYN1.02451611
59CSF1R0.97716174
60TAOK20.96721088
61PIM20.95973990
62NLK0.92941721
63SIK30.89117856
64LATS10.86405045
65LIMK10.85669802
66EGFR0.84527312
67PRKD10.79526805
68CSK0.79184556
69LCK0.74682356
70BTK0.72878580
71FGFR10.71322044
72PTK20.68666980
73NTRK10.67416967
74MAPK70.65418153
75PKN20.65259196
76MOS0.65157937
77MAP2K20.65077671
78KDR0.64519084
79CLK10.63541382
80ERBB20.63119662
81DDR20.60481256
82MAP2K30.59818882
83PTK2B0.59014996
84HCK0.58726009
85MAPK110.58622227
86TGFBR10.58516477
87CAMK1G0.58423602
88MAP3K10.57869124
89PRKCQ0.57605494
90DAPK10.53396523
91PDPK10.51360878
92YES10.49754387
93NEK90.49149862
94DAPK30.48921321
95PRKG20.48473916
96BMX0.48468189
97PDK10.48273663
98MAP2K10.47915610
99MARK20.46806897
100ITK0.46667090
101RPS6KA50.46406688
102TTN0.45157707
103RPS6KA40.43977909
104JAK10.43346703
105INSR0.43069103
106MATK0.41515917
107MAP3K120.41180986
108CDK120.40274754
109PIM10.40267660
110TYRO30.38516571
111RET0.38491895
112HIPK20.37713845
113ABL10.37101176
114TEC0.37055247
115SIK20.36793828
116MAPKAPK20.36754646
117MAP3K50.35797229
118WNK40.35644001
119ROCK20.34877618
120IRAK20.34239481
121TYK20.34103708
122FGR0.33047855
123CHUK0.32493319
124DMPK0.32462196
125SGK30.32072434
126MAP3K70.31002427
127BLK0.30489487
128RPS6KA20.29928115
129NME20.29784336
130PRKCH0.29658821
131BRD40.29571188
132MAPK40.29380139
133TBK10.28201276
134MAPK30.27810701
135IGF1R0.27710809
136MARK30.27586500
137MELK0.26294797
138FYN0.26117563
139FES0.24527505
140ROCK10.24509212
141PKN10.23618130
142TAOK10.23032735
143PRKCD0.22907805
144SMG10.22554618
145EIF2AK20.21715405
146TRPM70.21503576
147JAK20.20918904
148PRKCE0.20810224
149STK390.20707858
150BCR0.20596748
151CDC42BPA0.19533655
152STK30.19020970
153DYRK1B0.18776385

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.11520937
2Mineral absorption_Homo sapiens_hsa049783.68766348
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.41998076
4Autoimmune thyroid disease_Homo sapiens_hsa053203.31862541
5Graft-versus-host disease_Homo sapiens_hsa053323.20065121
6Asthma_Homo sapiens_hsa053103.15451020
7Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.06333605
8Type I diabetes mellitus_Homo sapiens_hsa049402.98420372
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.83357463
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.82237540
11Fatty acid biosynthesis_Homo sapiens_hsa000612.75350650
12Leishmaniasis_Homo sapiens_hsa051402.62631120
13ECM-receptor interaction_Homo sapiens_hsa045122.53520567
14Caffeine metabolism_Homo sapiens_hsa002322.42183182
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.42178047
16Adherens junction_Homo sapiens_hsa045202.35327458
17African trypanosomiasis_Homo sapiens_hsa051432.34407334
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.26369218
19Influenza A_Homo sapiens_hsa051642.13863960
20Osteoclast differentiation_Homo sapiens_hsa043802.06846568
21Phagosome_Homo sapiens_hsa041452.04698847
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.94780215
23Measles_Homo sapiens_hsa051621.93951371
24Tight junction_Homo sapiens_hsa045301.92511374
25Antigen processing and presentation_Homo sapiens_hsa046121.83861969
26Herpes simplex infection_Homo sapiens_hsa051681.82942630
27Primary immunodeficiency_Homo sapiens_hsa053401.73942239
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.72825794
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.68676506
30* Lysosome_Homo sapiens_hsa041421.67774366
31Focal adhesion_Homo sapiens_hsa045101.62504406
32Pertussis_Homo sapiens_hsa051331.61900063
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.58397458
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.55791885
35Renin-angiotensin system_Homo sapiens_hsa046141.53994690
36Bladder cancer_Homo sapiens_hsa052191.52660940
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50050102
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47727898
39Hippo signaling pathway_Homo sapiens_hsa043901.44931893
40B cell receptor signaling pathway_Homo sapiens_hsa046621.44608439
41Fatty acid elongation_Homo sapiens_hsa000621.42682920
42Malaria_Homo sapiens_hsa051441.41046392
43Legionellosis_Homo sapiens_hsa051341.37476667
44Chemokine signaling pathway_Homo sapiens_hsa040621.33973661
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.32946760
46Amoebiasis_Homo sapiens_hsa051461.32854741
47Hematopoietic cell lineage_Homo sapiens_hsa046401.32629188
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32602981
49ABC transporters_Homo sapiens_hsa020101.31848542
50Vibrio cholerae infection_Homo sapiens_hsa051101.30272369
51Histidine metabolism_Homo sapiens_hsa003401.24924944
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22981591
53Small cell lung cancer_Homo sapiens_hsa052221.22066699
54Renal cell carcinoma_Homo sapiens_hsa052111.21312866
55Ether lipid metabolism_Homo sapiens_hsa005651.18573062
56Fatty acid degradation_Homo sapiens_hsa000711.17491980
57Other glycan degradation_Homo sapiens_hsa005111.16024088
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15623372
59VEGF signaling pathway_Homo sapiens_hsa043701.14374248
60Rap1 signaling pathway_Homo sapiens_hsa040151.10873790
61Gastric acid secretion_Homo sapiens_hsa049711.08461101
62Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06090494
63Hepatitis B_Homo sapiens_hsa051611.05555406
64Platelet activation_Homo sapiens_hsa046111.02315705
65Endocytosis_Homo sapiens_hsa041441.01272490
66Proteoglycans in cancer_Homo sapiens_hsa052051.01243683
67Tryptophan metabolism_Homo sapiens_hsa003801.00084170
68Toxoplasmosis_Homo sapiens_hsa051450.99804794
69Thyroid cancer_Homo sapiens_hsa052160.98902653
70Fatty acid metabolism_Homo sapiens_hsa012120.92940836
71Rheumatoid arthritis_Homo sapiens_hsa053230.91832028
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90918569
73Axon guidance_Homo sapiens_hsa043600.89899408
74Renin secretion_Homo sapiens_hsa049240.89610937
75Endometrial cancer_Homo sapiens_hsa052130.89126405
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86337450
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85829945
78Collecting duct acid secretion_Homo sapiens_hsa049660.85757098
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84512972
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.83966923
81Pancreatic cancer_Homo sapiens_hsa052120.83891853
82Epstein-Barr virus infection_Homo sapiens_hsa051690.81683639
83Dorso-ventral axis formation_Homo sapiens_hsa043200.81649748
84Viral myocarditis_Homo sapiens_hsa054160.80184384
85Salmonella infection_Homo sapiens_hsa051320.79856791
86TGF-beta signaling pathway_Homo sapiens_hsa043500.79674817
87Bile secretion_Homo sapiens_hsa049760.78011252
88Glutathione metabolism_Homo sapiens_hsa004800.77560428
89Taste transduction_Homo sapiens_hsa047420.77269276
90Sphingolipid metabolism_Homo sapiens_hsa006000.75429533
91Complement and coagulation cascades_Homo sapiens_hsa046100.73635301
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.73316275
93T cell receptor signaling pathway_Homo sapiens_hsa046600.73285503
94Selenocompound metabolism_Homo sapiens_hsa004500.72203091
95Hepatitis C_Homo sapiens_hsa051600.71988420
96Prion diseases_Homo sapiens_hsa050200.71817025
97Pathways in cancer_Homo sapiens_hsa052000.70310060
98Salivary secretion_Homo sapiens_hsa049700.70177895
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70003369
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69420997
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.67465962
102Dilated cardiomyopathy_Homo sapiens_hsa054140.66914529
103Systemic lupus erythematosus_Homo sapiens_hsa053220.64780147
104PPAR signaling pathway_Homo sapiens_hsa033200.64280628
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.64016194
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.62804258
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61290047
108Chronic myeloid leukemia_Homo sapiens_hsa052200.59261797
109Thyroid hormone synthesis_Homo sapiens_hsa049180.58397681
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54034342
111Acute myeloid leukemia_Homo sapiens_hsa052210.53810470
112Apoptosis_Homo sapiens_hsa042100.53790622
113Inositol phosphate metabolism_Homo sapiens_hsa005620.53179021
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52077407
115Staphylococcus aureus infection_Homo sapiens_hsa051500.51539199
116Insulin resistance_Homo sapiens_hsa049310.51398491
117HTLV-I infection_Homo sapiens_hsa051660.51178053
118Chemical carcinogenesis_Homo sapiens_hsa052040.49823922
119Colorectal cancer_Homo sapiens_hsa052100.48458030
120TNF signaling pathway_Homo sapiens_hsa046680.48354642
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48121526
122Shigellosis_Homo sapiens_hsa051310.47920567
123Peroxisome_Homo sapiens_hsa041460.44787155
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44169537
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43841763
126Estrogen signaling pathway_Homo sapiens_hsa049150.43519124
127MicroRNAs in cancer_Homo sapiens_hsa052060.42475409
128Viral carcinogenesis_Homo sapiens_hsa052030.41185075
129Prostate cancer_Homo sapiens_hsa052150.40057725
130Prolactin signaling pathway_Homo sapiens_hsa049170.39858996
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.38934132
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37787450
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37170280
134Melanoma_Homo sapiens_hsa052180.37142372
135Tuberculosis_Homo sapiens_hsa051520.37091179
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.36670781
137Basal cell carcinoma_Homo sapiens_hsa052170.36134378
138Melanogenesis_Homo sapiens_hsa049160.35879756
139Notch signaling pathway_Homo sapiens_hsa043300.35578212
140Type II diabetes mellitus_Homo sapiens_hsa049300.34566364
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29810505
142HIF-1 signaling pathway_Homo sapiens_hsa040660.24468092
143MAPK signaling pathway_Homo sapiens_hsa040100.21422546
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21392611
145FoxO signaling pathway_Homo sapiens_hsa040680.19466544
146Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18482817
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16417191
148GnRH signaling pathway_Homo sapiens_hsa049120.14927627
149Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.11601471
150Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.11588339
151alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10041197
152Sulfur metabolism_Homo sapiens_hsa009200.09525781
153Ovarian steroidogenesis_Homo sapiens_hsa049130.05018010

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »