LAMP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-amino acid import (GO:0043092)8.55242344
2glycine transport (GO:0015816)7.69759903
3amino acid import (GO:0043090)7.01078490
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act6.42218228
5synaptic vesicle docking involved in exocytosis (GO:0016081)6.11477633
6glutamate secretion (GO:0014047)5.94066076
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.88866320
8synaptic vesicle exocytosis (GO:0016079)5.85868349
9neurotransmitter-gated ion channel clustering (GO:0072578)5.82248596
10regulation of short-term neuronal synaptic plasticity (GO:0048172)5.79725140
11vocalization behavior (GO:0071625)5.64518020
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.61867338
13regulation of glutamate receptor signaling pathway (GO:1900449)5.59835254
14protein localization to synapse (GO:0035418)5.42252076
15presynaptic membrane assembly (GO:0097105)5.34524388
16neuron cell-cell adhesion (GO:0007158)5.33665857
17negative regulation of synaptic transmission, GABAergic (GO:0032229)5.33601652
18neuronal action potential propagation (GO:0019227)5.31354196
19regulation of synaptic vesicle exocytosis (GO:2000300)5.31156740
20synaptic vesicle maturation (GO:0016188)5.04163667
21presynaptic membrane organization (GO:0097090)4.88035062
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.85838625
23gamma-aminobutyric acid signaling pathway (GO:0007214)4.68958889
24regulation of synaptic vesicle transport (GO:1902803)4.61879075
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.59132233
26glutamate receptor signaling pathway (GO:0007215)4.55258736
27neurotransmitter secretion (GO:0007269)4.53235566
28sodium ion export (GO:0071436)4.49056664
29postsynaptic membrane organization (GO:0001941)4.44330396
30neuron-neuron synaptic transmission (GO:0007270)4.40822898
31synaptic transmission, glutamatergic (GO:0035249)4.37876755
32regulation of excitatory postsynaptic membrane potential (GO:0060079)4.33577751
33locomotory exploration behavior (GO:0035641)4.29737913
34regulation of ARF protein signal transduction (GO:0032012)4.23711087
35regulation of postsynaptic membrane potential (GO:0060078)4.17023777
36regulation of long-term neuronal synaptic plasticity (GO:0048169)4.16424123
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.14208112
38long-term synaptic potentiation (GO:0060291)4.05906922
39neurofilament cytoskeleton organization (GO:0060052)4.02546608
40positive regulation of membrane potential (GO:0045838)4.02283694
41regulation of neuronal synaptic plasticity (GO:0048168)3.96936366
42positive regulation of neurotransmitter secretion (GO:0001956)3.86351939
43response to histamine (GO:0034776)3.84753080
44cerebellar granule cell differentiation (GO:0021707)3.83278797
45regulation of synaptic plasticity (GO:0048167)3.82758011
46behavioral response to cocaine (GO:0048148)3.73781369
47regulation of synaptic transmission, glutamatergic (GO:0051966)3.69969570
48gamma-aminobutyric acid transport (GO:0015812)3.67628982
49regulation of neurotransmitter secretion (GO:0046928)3.65983899
50startle response (GO:0001964)3.65355707
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64789002
52positive regulation of synapse maturation (GO:0090129)3.62382659
53exploration behavior (GO:0035640)3.59069045
54neurotransmitter uptake (GO:0001504)3.58935703
55regulation of dendritic spine morphogenesis (GO:0061001)3.58699959
56positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.55428618
57neurotransmitter transport (GO:0006836)3.55173867
58G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.53617484
59neuron recognition (GO:0008038)3.53352224
60energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.52734961
61ATP hydrolysis coupled proton transport (GO:0015991)3.52734961
62proline transport (GO:0015824)3.49727375
63cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.49549059
64vesicle docking involved in exocytosis (GO:0006904)3.49212570
65serotonin metabolic process (GO:0042428)3.46957708
66regulation of voltage-gated calcium channel activity (GO:1901385)3.46429684
67response to auditory stimulus (GO:0010996)3.42786176
68positive regulation of neurotransmitter transport (GO:0051590)3.42492185
69cerebellar Purkinje cell differentiation (GO:0021702)3.41960285
70regulation of dendritic spine development (GO:0060998)3.40081849
71G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.39207159
72regulation of glutamate secretion (GO:0014048)3.37211349
73negative regulation of dendrite morphogenesis (GO:0050774)3.37184254
74long-term memory (GO:0007616)3.35870151
75membrane depolarization (GO:0051899)3.35279931
76negative regulation of amino acid transport (GO:0051956)3.34379033
77potassium ion homeostasis (GO:0055075)3.32312603
78regulation of neurotransmitter transport (GO:0051588)3.31560559
79regulation of vesicle fusion (GO:0031338)3.29624967
80neuromuscular process controlling balance (GO:0050885)3.28806232
81regulation of neurotransmitter levels (GO:0001505)3.28724435
82membrane hyperpolarization (GO:0060081)3.27284505
83positive regulation of synapse assembly (GO:0051965)3.26818557
84layer formation in cerebral cortex (GO:0021819)3.26764010
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.26407025
86membrane depolarization during action potential (GO:0086010)3.23512204
87cellular sodium ion homeostasis (GO:0006883)3.23126413
88positive regulation of synaptic transmission (GO:0050806)3.22112186
89cellular potassium ion homeostasis (GO:0030007)3.21706911
90acidic amino acid transport (GO:0015800)3.20718768
91activation of protein kinase A activity (GO:0034199)3.20375863
92transferrin transport (GO:0033572)3.20015493
93establishment of synaptic vesicle localization (GO:0097480)3.18547321
94synaptic vesicle transport (GO:0048489)3.18547321
95synaptic transmission (GO:0007268)3.15990048
96synaptic vesicle endocytosis (GO:0048488)3.14229464
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.14045547
98dendritic spine morphogenesis (GO:0060997)3.14001116
99axonal fasciculation (GO:0007413)3.12645766
100regulation of synapse structural plasticity (GO:0051823)3.11489667
101regulation of synaptic transmission (GO:0050804)3.10368837
102neuromuscular synaptic transmission (GO:0007274)3.09759626
103positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.09384092
104mechanosensory behavior (GO:0007638)3.06850074
105long term synaptic depression (GO:0060292)3.05305037
106vesicle docking (GO:0048278)3.05299639
107neuronal ion channel clustering (GO:0045161)3.04961839
108learning (GO:0007612)3.03130079
109phosphorelay signal transduction system (GO:0000160)3.02715257
110potassium ion import (GO:0010107)3.02596255
111establishment of mitochondrion localization (GO:0051654)3.02353112
112detection of calcium ion (GO:0005513)3.00576366
113fear response (GO:0042596)2.99795716
114auditory behavior (GO:0031223)2.99541983
115synapse assembly (GO:0007416)2.98335861
116positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97232990
117negative regulation of dendrite development (GO:2000171)2.96559737
118central nervous system projection neuron axonogenesis (GO:0021952)2.96124775
119ferric iron transport (GO:0015682)2.96080317
120trivalent inorganic cation transport (GO:0072512)2.96080317
121regulation of respiratory system process (GO:0044065)2.95906838
122cell communication by electrical coupling (GO:0010644)2.94971475
123primary amino compound metabolic process (GO:1901160)2.92470664
124regulation of synaptic transmission, GABAergic (GO:0032228)2.91870613
125calcium ion-dependent exocytosis (GO:0017156)2.90073880
126behavioral defense response (GO:0002209)2.89269490
127behavioral fear response (GO:0001662)2.89269490
128cochlea development (GO:0090102)2.89207427
129regulation of synapse maturation (GO:0090128)2.87697251
130regulation of respiratory gaseous exchange (GO:0043576)2.85904163
131L-glutamate transport (GO:0015813)2.84433404
132dendritic spine organization (GO:0097061)2.82583055
133cell migration in hindbrain (GO:0021535)2.81694461
134neuromuscular process controlling posture (GO:0050884)2.78925005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.90279929
2GBX2_23144817_ChIP-Seq_PC3_Human4.57560108
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.31255924
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.18434837
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04717730
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.77442986
7REST_21632747_ChIP-Seq_MESCs_Mouse2.68074702
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67432087
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67432087
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.66471263
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60981280
12TAF15_26573619_Chip-Seq_HEK293_Human2.59851742
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58058703
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56375364
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.47145584
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.43526316
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42557908
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40961794
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33704990
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17965969
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.17340544
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17030077
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16539290
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13498426
25DROSHA_22980978_ChIP-Seq_HELA_Human2.13310212
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.09537377
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06911318
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01892533
29EZH2_27294783_Chip-Seq_ESCs_Mouse2.01559754
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99932401
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84663978
32AR_21572438_ChIP-Seq_LNCaP_Human1.84362709
33SMAD4_21799915_ChIP-Seq_A2780_Human1.84241179
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83521819
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82060531
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.81952127
37P300_19829295_ChIP-Seq_ESCs_Human1.80742063
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71233073
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69331165
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68461963
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.64703411
42FUS_26573619_Chip-Seq_HEK293_Human1.64232496
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62108262
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.58790056
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57378940
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57172107
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51807423
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.51673559
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48084595
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47766701
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46315491
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45120420
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.40343246
54AR_25329375_ChIP-Seq_VCAP_Human1.38813282
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38703000
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37195316
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36426776
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.35277053
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34450218
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34328294
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.34114936
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33662621
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31599927
64VDR_22108803_ChIP-Seq_LS180_Human1.29849656
65VDR_21846776_ChIP-Seq_THP-1_Human1.28095482
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27585325
67STAT3_23295773_ChIP-Seq_U87_Human1.25973663
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.23762589
69RNF2_27304074_Chip-Seq_NSC_Mouse1.19911900
70OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19898646
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19890413
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19791214
73TCF4_23295773_ChIP-Seq_U87_Human1.19465226
74ZNF274_21170338_ChIP-Seq_K562_Hela1.18330383
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17274028
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15073347
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.12957865
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11146940
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.10789204
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.10510952
81ER_23166858_ChIP-Seq_MCF-7_Human1.10267988
82AR_19668381_ChIP-Seq_PC3_Human1.09706338
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09330558
84RXR_22108803_ChIP-Seq_LS180_Human1.07983075
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07274804
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07274804
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07105929
88RUNX2_22187159_ChIP-Seq_PCA_Human1.06983236
89ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06960290
90SCL_19346495_ChIP-Seq_HPC-7_Human1.04718128
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.04329082
92JUN_21703547_ChIP-Seq_K562_Human1.04304483
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03779347
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03439968
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02311320
96KDM2B_26808549_Chip-Seq_K562_Human1.01357563
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00383869
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99994170
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98852950
100TP53_18474530_ChIP-ChIP_U2OS_Human0.98330162
101AHR_22903824_ChIP-Seq_MCF-7_Human0.98284685
102LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98037511
103DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97028083
104WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96620336
105SOX9_26525672_Chip-Seq_HEART_Mouse0.96173285
106SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95911344
107ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95865287
108CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95193815
109TP53_16413492_ChIP-PET_HCT116_Human0.94116976
110E2F1_18555785_Chip-Seq_ESCs_Mouse0.92817123
111BCAT_22108803_ChIP-Seq_LS180_Human0.92093365
112RUNX1_26923725_Chip-Seq_HPCs_Mouse0.91758848
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91026899
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.90825262
115CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90151381
116CBP_20019798_ChIP-Seq_JUKART_Human0.89902027
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89902027
118P53_22387025_ChIP-Seq_ESCs_Mouse0.89489163
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89182559
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88940401
121CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87372163
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.86863765
123LXR_22292898_ChIP-Seq_THP-1_Human0.86722713
124WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85013115
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84943564
126OCT4_19829295_ChIP-Seq_ESCs_Human0.83557865
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82684248
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.81719148
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80612255
130ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79789234
131VDR_24763502_ChIP-Seq_THP-1_Human0.79602242
132DPY_21335234_ChIP-Seq_ESCs_Mouse0.77513123
133EGR1_19032775_ChIP-ChIP_M12_Human0.76858977
134TAL1_26923725_Chip-Seq_HPCs_Mouse0.75939662
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75114435
136IGF1R_20145208_ChIP-Seq_DFB_Human0.75107346

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.58650848
2MP0004859_abnormal_synaptic_plasticity6.09733907
3MP0003635_abnormal_synaptic_transmissio4.26807840
4MP0009745_abnormal_behavioral_response3.71868887
5MP0004270_analgesia3.61930331
6MP0001968_abnormal_touch/_nociception3.54197039
7MP0009046_muscle_twitch3.53826020
8MP0002064_seizures3.46549190
9MP0002063_abnormal_learning/memory/cond3.38804736
10MP0002572_abnormal_emotion/affect_behav2.98013624
11MP0002736_abnormal_nociception_after2.89977327
12MP0001486_abnormal_startle_reflex2.83702173
13MP0002272_abnormal_nervous_system2.70689950
14MP0002734_abnormal_mechanical_nocicepti2.51127705
15MP0001440_abnormal_grooming_behavior2.44007645
16MP0001501_abnormal_sleep_pattern2.41633080
17MP0002822_catalepsy2.20899904
18MP0002067_abnormal_sensory_capabilities2.18833576
19MP0003879_abnormal_hair_cell2.17409162
20MP0005423_abnormal_somatic_nervous2.02285342
21MP0002735_abnormal_chemical_nociception1.95593714
22MP0002733_abnormal_thermal_nociception1.90697496
23MP0001984_abnormal_olfaction1.86813901
24MP0001970_abnormal_pain_threshold1.84632137
25MP0002653_abnormal_ependyma_morphology1.82062264
26MP0008569_lethality_at_weaning1.78611673
27MP0009780_abnormal_chondrocyte_physiolo1.78145735
28MP0002638_abnormal_pupillary_reflex1.72863066
29MP0005386_behavior/neurological_phenoty1.71178540
30MP0004924_abnormal_behavior1.71178540
31MP0003329_amyloid_beta_deposits1.64800099
32MP0005646_abnormal_pituitary_gland1.62406376
33MP0002557_abnormal_social/conspecific_i1.60595596
34MP0001529_abnormal_vocalization1.60526793
35MP0003787_abnormal_imprinting1.57382745
36MP0000778_abnormal_nervous_system1.56879993
37MP0002184_abnormal_innervation1.53886953
38MP0001188_hyperpigmentation1.51878427
39MP0002837_dystrophic_cardiac_calcinosis1.48925325
40MP0004811_abnormal_neuron_physiology1.46625818
41MP0002066_abnormal_motor_capabilities/c1.38688281
42MP0003633_abnormal_nervous_system1.37907245
43MP0006276_abnormal_autonomic_nervous1.34488091
44MP0005464_abnormal_platelet_physiology1.32873634
45MP0004142_abnormal_muscle_tone1.31467180
46MP0000955_abnormal_spinal_cord1.30975089
47MP0003136_yellow_coat_color1.23935386
48MP0002882_abnormal_neuron_morphology1.23525303
49MP0001905_abnormal_dopamine_level1.21040452
50MP0000013_abnormal_adipose_tissue1.19847072
51MP0008872_abnormal_physiological_respon1.19838423
52MP0001502_abnormal_circadian_rhythm1.15772770
53MP0002876_abnormal_thyroid_physiology1.13477071
54MP0004858_abnormal_nervous_system1.12644455
55MP0003631_nervous_system_phenotype1.12021996
56MP0004145_abnormal_muscle_electrophysio1.10091308
57MP0002909_abnormal_adrenal_gland1.09295268
58MP0003283_abnormal_digestive_organ1.05798273
59MP0005551_abnormal_eye_electrophysiolog1.05756787
60MP0005171_absent_coat_pigmentation1.05101480
61MP0008004_abnormal_stomach_pH1.04668173
62MP0000751_myopathy1.04667559
63MP0001986_abnormal_taste_sensitivity1.04045285
64MP0008874_decreased_physiological_sensi1.03853154
65MP0003303_peritoneal_inflammation1.03683030
66MP0004885_abnormal_endolymph1.03224843
67MP0003122_maternal_imprinting1.02197454
68MP0003183_abnormal_peptide_metabolism0.96130916
69MP0003385_abnormal_body_wall0.96051959
70MP0004484_altered_response_of0.96035444
71MP0001963_abnormal_hearing_physiology0.94471884
72MP0002152_abnormal_brain_morphology0.93344363
73MP0005535_abnormal_body_temperature0.91840677
74MP0004742_abnormal_vestibular_system0.91835038
75MP0000569_abnormal_digit_pigmentation0.90644055
76MP0004215_abnormal_myocardial_fiber0.89451371
77MP0001485_abnormal_pinna_reflex0.89364397
78MP0002229_neurodegeneration0.88427510
79MP0010386_abnormal_urinary_bladder0.87583703
80MP0002069_abnormal_eating/drinking_beha0.86725569
81MP0003172_abnormal_lysosome_physiology0.86535312
82MP0004085_abnormal_heartbeat0.85393605
83MP0001177_atelectasis0.83689198
84MP0005167_abnormal_blood-brain_barrier0.73782023
85MP0001664_abnormal_digestion0.72686959
86MP0000604_amyloidosis0.72264683
87MP0005645_abnormal_hypothalamus_physiol0.71510611
88MP0001346_abnormal_lacrimal_gland0.69200446
89MP0002089_abnormal_postnatal_growth/wei0.65258092
90MP0002752_abnormal_somatic_nervous0.64478120
91MP0003938_abnormal_ear_development0.63519415
92MP0000920_abnormal_myelination0.63440861
93MP0002090_abnormal_vision0.63235514
94MP0004130_abnormal_muscle_cell0.63033287
95MP0004510_myositis0.62923145
96MP0003690_abnormal_glial_cell0.62759315
97MP0003632_abnormal_nervous_system0.62114584
98MP0005388_respiratory_system_phenotype0.62031749
99MP0002133_abnormal_respiratory_system0.62031749
100MP0000631_abnormal_neuroendocrine_gland0.61482726
101MP0001943_abnormal_respiration0.61172033
102MP0000534_abnormal_ureter_morphology0.60177260
103MP0001348_abnormal_lacrimal_gland0.58796004
104MP0004233_abnormal_muscle_weight0.58061329
105MP0003075_altered_response_to0.57925437
106MP0005084_abnormal_gallbladder_morpholo0.57804864
107MP0005499_abnormal_olfactory_system0.56401839
108MP0005394_taste/olfaction_phenotype0.56401839
109MP0005623_abnormal_meninges_morphology0.56203219
110MP0004043_abnormal_pH_regulation0.54605583
111MP0002083_premature_death0.54230499
112MP0000681_abnormal_thyroid_gland0.53534068
113MP0003861_abnormal_nervous_system0.53013611
114MP0004134_abnormal_chest_morphology0.52550814
115MP0002082_postnatal_lethality0.51769541
116MP0010770_preweaning_lethality0.51769541
117MP0003634_abnormal_glial_cell0.51644268
118MP0000026_abnormal_inner_ear0.51431082
119MP0010769_abnormal_survival0.50392722
120MP0003956_abnormal_body_size0.48313177
121MP0010768_mortality/aging0.47917264
122MP0008877_abnormal_DNA_methylation0.46768460
123MP0001765_abnormal_ion_homeostasis0.45923298
124MP0005620_abnormal_muscle_contractility0.44926782

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.51893735
2Epileptic encephalopathy (HP:0200134)6.87181779
3Atonic seizures (HP:0010819)6.46323966
4Focal seizures (HP:0007359)6.11630526
5Myokymia (HP:0002411)5.45345511
6Febrile seizures (HP:0002373)5.39571889
7Hyperventilation (HP:0002883)5.28431403
8Absence seizures (HP:0002121)4.94266055
9Dialeptic seizures (HP:0011146)4.64947105
10Broad-based gait (HP:0002136)4.27368305
11Visual hallucinations (HP:0002367)4.08709998
12Generalized tonic-clonic seizures (HP:0002069)4.03704636
13Progressive cerebellar ataxia (HP:0002073)3.98883418
14Poor eye contact (HP:0000817)3.95191288
15Gaze-evoked nystagmus (HP:0000640)3.94124535
16Amblyopia (HP:0000646)3.90509727
17Papilledema (HP:0001085)3.90448226
18Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.62044971
19Abnormal social behavior (HP:0012433)3.40322547
20Impaired social interactions (HP:0000735)3.40322547
21Dysmetric saccades (HP:0000641)3.26750998
22Impaired vibration sensation in the lower limbs (HP:0002166)3.25880749
23Abnormal eating behavior (HP:0100738)3.21584248
24Epileptiform EEG discharges (HP:0011182)3.13437167
25Dysdiadochokinesis (HP:0002075)3.08846581
26Inability to walk (HP:0002540)3.07263416
27Truncal ataxia (HP:0002078)3.02247431
28Protruding tongue (HP:0010808)2.98839198
29Chronic bronchitis (HP:0004469)2.91486204
30Dysmetria (HP:0001310)2.90094379
31Decreased circulating renin level (HP:0003351)2.86212990
32Drooling (HP:0002307)2.84831039
33Excessive salivation (HP:0003781)2.84831039
34Neuronal loss in central nervous system (HP:0002529)2.76673500
35Depression (HP:0000716)2.74527917
36Impaired smooth pursuit (HP:0007772)2.73193265
37Urinary bladder sphincter dysfunction (HP:0002839)2.73156332
38Scanning speech (HP:0002168)2.69315301
39Status epilepticus (HP:0002133)2.68382457
40Absent speech (HP:0001344)2.65482991
41Stereotypic behavior (HP:0000733)2.63358996
42Action tremor (HP:0002345)2.60343575
43Anxiety (HP:0000739)2.59365821
44EEG with generalized epileptiform discharges (HP:0011198)2.57846600
45Insidious onset (HP:0003587)2.54447078
46Termporal pattern (HP:0011008)2.54447078
47Sensory axonal neuropathy (HP:0003390)2.52166263
48Impaired vibratory sensation (HP:0002495)2.51262210
49Hypokalemic alkalosis (HP:0001949)2.49360945
50Supranuclear gaze palsy (HP:0000605)2.49148003
51Turricephaly (HP:0000262)2.44801607
52Postural instability (HP:0002172)2.42690322
53Nuclear cataract (HP:0100018)2.40200925
54Hemiparesis (HP:0001269)2.40023359
55Annular pancreas (HP:0001734)2.38565109
56Hyperactive renin-angiotensin system (HP:0000841)2.36099759
57Hypsarrhythmia (HP:0002521)2.35944165
58Ankle clonus (HP:0011448)2.32368951
59Urinary urgency (HP:0000012)2.30460906
60Resting tremor (HP:0002322)2.30390997
61Abnormality of incisor morphology (HP:0011063)2.30298746
62Tetraplegia (HP:0002445)2.29928509
63Progressive inability to walk (HP:0002505)2.29684408
64Abnormality of the lower motor neuron (HP:0002366)2.28975323
65Blue irides (HP:0000635)2.28316343
66Mutism (HP:0002300)2.28265644
67Limb dystonia (HP:0002451)2.26592179
68Generalized myoclonic seizures (HP:0002123)2.26136398
69Abnormality of binocular vision (HP:0011514)2.24602935
70Diplopia (HP:0000651)2.24602935
71Abnormality of ocular smooth pursuit (HP:0000617)2.23091317
72Acute necrotizing encephalopathy (HP:0006965)2.21299275
73Bradykinesia (HP:0002067)2.20375229
74Clonus (HP:0002169)2.19469911
75CNS hypomyelination (HP:0003429)2.19329770
76Thickened helices (HP:0000391)2.18446162
77Fetal akinesia sequence (HP:0001989)2.17539777
78Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.17248192
79Abnormality of lateral ventricle (HP:0030047)2.17115078
80Gait ataxia (HP:0002066)2.17046063
81Genetic anticipation (HP:0003743)2.15521879
82Incomplete penetrance (HP:0003829)2.15464232
83Progressive macrocephaly (HP:0004481)2.11903437
84Gait imbalance (HP:0002141)2.11803948
85Abnormal mitochondria in muscle tissue (HP:0008316)2.10454605
86Prolonged bleeding time (HP:0003010)2.10186874
87Recurrent sinusitis (HP:0011108)2.06772054
88Polyphagia (HP:0002591)2.06003083
89Focal dystonia (HP:0004373)2.03696972
90Degeneration of the lateral corticospinal tracts (HP:0002314)2.03395935
91Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.03395935
92Abnormal ciliary motility (HP:0012262)2.02839160
93Torticollis (HP:0000473)2.01762488
94Hyperthyroidism (HP:0000836)2.01479578
95Fair hair (HP:0002286)2.01197234
96Pheochromocytoma (HP:0002666)2.00526515
97Spastic gait (HP:0002064)2.00123185
98Paraplegia (HP:0010550)1.98014764
99Abnormality of salivation (HP:0100755)1.96872499
100Congenital primary aphakia (HP:0007707)1.93108799
101Specific learning disability (HP:0001328)1.90339874
102Delusions (HP:0000746)1.89730016
103Abnormality of the periventricular white matter (HP:0002518)1.89369379
104Abnormal hair whorl (HP:0010721)1.88327951
105Morphological abnormality of the pyramidal tract (HP:0002062)1.87656518
106Pointed chin (HP:0000307)1.87043121
107Spastic paraplegia (HP:0001258)1.85672793
108Abnormality of the corticospinal tract (HP:0002492)1.84936718
109Medial flaring of the eyebrow (HP:0010747)1.84092993
110Generalized hypopigmentation of hair (HP:0011358)1.84086146
111Insomnia (HP:0100785)1.82742434
112Short chin (HP:0000331)1.82589370
113Hemiplegia (HP:0002301)1.81664410
114Abnormality of saccadic eye movements (HP:0000570)1.81597415
115Athetosis (HP:0002305)1.81023249
116Hypoplasia of the corpus callosum (HP:0002079)1.80722609
117Unsteady gait (HP:0002317)1.80386102
118Clumsiness (HP:0002312)1.80240757
119Absent/shortened dynein arms (HP:0200106)1.79886770
120Dynein arm defect of respiratory motile cilia (HP:0012255)1.79886770
121Deeply set eye (HP:0000490)1.78936303
122Muscle stiffness (HP:0003552)1.78724061
123Intellectual disability, moderate (HP:0002342)1.78709619
124Nephrogenic diabetes insipidus (HP:0009806)1.78596079
125Cerebral inclusion bodies (HP:0100314)1.78177761
126Craniofacial dystonia (HP:0012179)1.77001929
127Lower limb muscle weakness (HP:0007340)1.76489299
128Intention tremor (HP:0002080)1.75637489
129Neurofibrillary tangles (HP:0002185)1.73768872
130Abnormal respiratory motile cilium physiology (HP:0012261)1.73302292
131Lower limb hyperreflexia (HP:0002395)1.72601193
132Spastic tetraparesis (HP:0001285)1.72128581
133Spinal canal stenosis (HP:0003416)1.72033704
134Megalencephaly (HP:0001355)1.71312210
135Mild short stature (HP:0003502)1.69957881
136Lower limb asymmetry (HP:0100559)1.66200951
137Nasal polyposis (HP:0100582)1.63650398
138Retinal dysplasia (HP:0007973)1.63129925

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.61115746
2CASK4.47050687
3NTRK34.19886802
4DAPK23.51717976
5MAP3K43.14605965
6CDK193.10198190
7MAP2K73.02783515
8MAP3K122.94535495
9CCNB12.92343835
10MAP3K92.70488230
11DAPK12.62698484
12RIPK42.61522029
13PLK22.17989344
14MAP2K42.05972564
15MINK12.01802339
16PAK61.93755007
17OXSR11.72413872
18KSR21.69289723
19KSR11.62752979
20AKT31.57132112
21PRPF4B1.49262946
22CDK51.41129131
23SIK21.37853809
24MARK11.36078806
25TAOK31.32567742
26CAMKK11.31076704
27PNCK1.30111447
28BMPR21.27381536
29ARAF1.25754182
30NTRK21.24988503
31NTRK11.16387108
32PRKCG1.16160485
33GRK51.10649080
34SIK31.05743787
35MAPK131.04387676
36CAMK2B1.04327421
37CAMKK21.03780768
38CAMK2A1.01734644
39MOS1.00956561
40MARK20.99955750
41PTK2B0.98194541
42FES0.96897798
43CDK180.95740326
44RAF10.95050284
45TNIK0.94872275
46MAP3K20.94508442
47DAPK30.92914554
48SGK4940.92275447
49SGK2230.92275447
50CDK150.89690363
51PRKD30.89388790
52MAP3K130.86584045
53UHMK10.85330376
54CDK140.85192570
55SGK20.81794325
56CDK11A0.78819540
57BMX0.78763056
58MAPK70.78753846
59MAP4K20.78002327
60PIM20.76802230
61STK380.73914323
62LATS20.72550507
63BRAF0.70147045
64NME10.68548098
65PDK30.68148323
66PDK40.68148323
67TAOK10.67191885
68CAMK10.66719748
69SGK10.66167459
70DYRK20.65599355
71STK110.65196402
72MAPK120.64998203
73MAPK100.63748188
74DYRK1B0.63241965
75PRKCE0.61983139
76BCKDK0.61139046
77BRD40.60754607
78TYRO30.60253298
79SYK0.57892878
80PDK10.56608844
81RET0.54062583
82FGR0.52814591
83PDPK10.52312050
84CSNK1G30.52067813
85BCR0.51029538
86SGK30.50502516
87MAP3K10.48414018
88PHKG10.48269360
89PHKG20.48269360
90CSNK1A1L0.46168357
91MAP2K10.46125352
92TNK20.44444323
93CAMK2D0.44194792
94PDK20.44190796
95MAP3K60.44141568
96TSSK60.43940113
97CSF1R0.43353015
98NEK10.43117842
99PRKCH0.42993924
100MAPK40.42412205
101CAMK2G0.41984415
102PINK10.41861103
103PKN10.40472517
104PTK20.40265838
105TEC0.38788612
106ROCK20.38260613
107PAK30.37853572
108NEK60.37374275
109RPS6KA30.36835434
110MYLK0.36814438
111FER0.35553713
112WNK10.35159975
113CSNK1G20.33672977
114FYN0.32883122
115MAP3K110.32647713
116DYRK1A0.32333589
117CSNK1A10.32199138
118JAK20.31165113
119PRKACA0.30079408
120CSNK1D0.29762489
121PRKCA0.29049896
122PRKCZ0.29031481
123BTK0.28645265
124MAPK80.28155113
125CDK30.27949030
126IRAK20.27935725
127PRKCB0.26849335
128MAPKAPK50.26227658
129CAMK40.23656227

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.31190740
2Synaptic vesicle cycle_Homo sapiens_hsa047213.70964699
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.94572592
4Long-term potentiation_Homo sapiens_hsa047202.87172109
5Circadian entrainment_Homo sapiens_hsa047132.75299641
6GABAergic synapse_Homo sapiens_hsa047272.72522731
7Collecting duct acid secretion_Homo sapiens_hsa049662.68170860
8Olfactory transduction_Homo sapiens_hsa047402.67159689
9Amphetamine addiction_Homo sapiens_hsa050312.64024644
10Morphine addiction_Homo sapiens_hsa050322.61090014
11Glutamatergic synapse_Homo sapiens_hsa047242.53570517
12Salivary secretion_Homo sapiens_hsa049702.34396128
13Dopaminergic synapse_Homo sapiens_hsa047282.13587708
14Renin secretion_Homo sapiens_hsa049242.03209138
15Insulin secretion_Homo sapiens_hsa049111.87504409
16Taste transduction_Homo sapiens_hsa047421.84061878
17Vitamin B6 metabolism_Homo sapiens_hsa007501.81533928
18Gastric acid secretion_Homo sapiens_hsa049711.81502088
19Oxytocin signaling pathway_Homo sapiens_hsa049211.81372396
20Long-term depression_Homo sapiens_hsa047301.79512867
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74410346
22Serotonergic synapse_Homo sapiens_hsa047261.67998295
23Calcium signaling pathway_Homo sapiens_hsa040201.63519152
24Vibrio cholerae infection_Homo sapiens_hsa051101.62935471
25Cholinergic synapse_Homo sapiens_hsa047251.61789279
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58582565
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55654306
28Cocaine addiction_Homo sapiens_hsa050301.50021579
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.43907757
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33044780
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31976094
32Oxidative phosphorylation_Homo sapiens_hsa001901.30649415
33Gap junction_Homo sapiens_hsa045401.28767931
34Cardiac muscle contraction_Homo sapiens_hsa042601.28097686
35GnRH signaling pathway_Homo sapiens_hsa049121.27413419
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21017262
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20897494
38cAMP signaling pathway_Homo sapiens_hsa040241.19779589
39Phototransduction_Homo sapiens_hsa047441.17826302
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14735917
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13761440
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06033856
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05834166
44Alzheimers disease_Homo sapiens_hsa050101.05413854
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05064411
46Estrogen signaling pathway_Homo sapiens_hsa049150.94568636
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.94198292
48Axon guidance_Homo sapiens_hsa043600.92460925
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91022601
50Glioma_Homo sapiens_hsa052140.88301335
51Melanogenesis_Homo sapiens_hsa049160.87592536
52ErbB signaling pathway_Homo sapiens_hsa040120.87575933
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85017152
54Type II diabetes mellitus_Homo sapiens_hsa049300.83432124
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80270121
56Parkinsons disease_Homo sapiens_hsa050120.74600758
57Dilated cardiomyopathy_Homo sapiens_hsa054140.73137808
58Platelet activation_Homo sapiens_hsa046110.72815723
59Endocytosis_Homo sapiens_hsa041440.71283431
60Pancreatic secretion_Homo sapiens_hsa049720.70051475
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69922631
62Rheumatoid arthritis_Homo sapiens_hsa053230.69580382
63Type I diabetes mellitus_Homo sapiens_hsa049400.69425710
64Oocyte meiosis_Homo sapiens_hsa041140.68742035
65MAPK signaling pathway_Homo sapiens_hsa040100.68563728
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60040333
67Regulation of autophagy_Homo sapiens_hsa041400.58043766
68Dorso-ventral axis formation_Homo sapiens_hsa043200.57886538
69African trypanosomiasis_Homo sapiens_hsa051430.56309138
70Glucagon signaling pathway_Homo sapiens_hsa049220.54553330
71Thyroid hormone synthesis_Homo sapiens_hsa049180.53780935
72Ras signaling pathway_Homo sapiens_hsa040140.52971862
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52641068
74VEGF signaling pathway_Homo sapiens_hsa043700.52380640
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52278737
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51015640
77Huntingtons disease_Homo sapiens_hsa050160.50393542
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50192707
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49056298
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.48081123
81Non-small cell lung cancer_Homo sapiens_hsa052230.48061341
82Inositol phosphate metabolism_Homo sapiens_hsa005620.48010417
83Chemokine signaling pathway_Homo sapiens_hsa040620.45828185
84Rap1 signaling pathway_Homo sapiens_hsa040150.44600480
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43329888
86B cell receptor signaling pathway_Homo sapiens_hsa046620.41027926
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.40869434
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40833301
89Choline metabolism in cancer_Homo sapiens_hsa052310.40444370
90Endometrial cancer_Homo sapiens_hsa052130.39982825
91Alcoholism_Homo sapiens_hsa050340.39130939
92Circadian rhythm_Homo sapiens_hsa047100.38703888
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38289655
94Nitrogen metabolism_Homo sapiens_hsa009100.37035031
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35960646
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.35331004
97Phagosome_Homo sapiens_hsa041450.33565153
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32642621
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32008116
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30755931
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30635296
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.29088985
103Renal cell carcinoma_Homo sapiens_hsa052110.28263075
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26925564
105Systemic lupus erythematosus_Homo sapiens_hsa053220.26488418
106Wnt signaling pathway_Homo sapiens_hsa043100.26467308
107AMPK signaling pathway_Homo sapiens_hsa041520.26346938
108Prion diseases_Homo sapiens_hsa050200.24683854
109Pyruvate metabolism_Homo sapiens_hsa006200.24393947
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24200149
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22765108
112Butanoate metabolism_Homo sapiens_hsa006500.21317510
113Bile secretion_Homo sapiens_hsa049760.20013650
114Insulin signaling pathway_Homo sapiens_hsa049100.19192601
115mTOR signaling pathway_Homo sapiens_hsa041500.17960212
116Ovarian steroidogenesis_Homo sapiens_hsa049130.17672458

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