LAMTOR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.46880039
2energy coupled proton transport, down electrochemical gradient (GO:0015985)7.04087493
3ATP synthesis coupled proton transport (GO:0015986)7.04087493
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.61631893
5respiratory electron transport chain (GO:0022904)6.04519928
6electron transport chain (GO:0022900)5.92047153
7ribosomal small subunit biogenesis (GO:0042274)5.36616806
8protein complex biogenesis (GO:0070271)4.92186465
9protein neddylation (GO:0045116)4.90623152
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.86006818
11NADH dehydrogenase complex assembly (GO:0010257)4.86006818
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.86006818
13chaperone-mediated protein transport (GO:0072321)4.84632934
14viral transcription (GO:0019083)4.71158208
15ribosomal small subunit assembly (GO:0000028)4.66596384
16sequestering of actin monomers (GO:0042989)4.61955741
17cotranslational protein targeting to membrane (GO:0006613)4.60247390
18aldehyde catabolic process (GO:0046185)4.56119928
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.55725303
20protein targeting to ER (GO:0045047)4.51314895
21translational termination (GO:0006415)4.50165007
22mitochondrial respiratory chain complex assembly (GO:0033108)4.47114371
23protein localization to endoplasmic reticulum (GO:0070972)4.36417856
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.31690744
25establishment of protein localization to endoplasmic reticulum (GO:0072599)4.26105408
26proteasome assembly (GO:0043248)4.19798636
27DNA deamination (GO:0045006)4.15699274
28regulation of mitochondrial translation (GO:0070129)3.82752808
29GDP-mannose metabolic process (GO:0019673)3.80969165
30oxidative phosphorylation (GO:0006119)3.77678558
31translational elongation (GO:0006414)3.75285587
32hydrogen ion transmembrane transport (GO:1902600)3.71057237
33viral life cycle (GO:0019058)3.67533582
34ATP biosynthetic process (GO:0006754)3.64114823
35L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.64101544
36respiratory chain complex IV assembly (GO:0008535)3.61313966
37regulation of cellular amino acid metabolic process (GO:0006521)3.59446928
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.59356331
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.59356331
40translation (GO:0006412)3.57156733
41protein targeting to mitochondrion (GO:0006626)3.55603086
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.54870069
43cellular protein complex disassembly (GO:0043624)3.54543410
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.52962322
45purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.51115380
46purine nucleoside triphosphate biosynthetic process (GO:0009145)3.50675043
47nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.49205884
48establishment of protein localization to mitochondrion (GO:0072655)3.48845351
49platelet dense granule organization (GO:0060155)3.45744597
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.42421362
51termination of RNA polymerase III transcription (GO:0006386)3.42421362
52cytochrome complex assembly (GO:0017004)3.41111836
53pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.36629600
54proton transport (GO:0015992)3.36604208
55positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.36023025
56antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.35506748
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.34176324
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.32087266
59negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31380700
60base-excision repair, AP site formation (GO:0006285)3.29942415
61inner mitochondrial membrane organization (GO:0007007)3.29123932
62hydrogen transport (GO:0006818)3.28957417
63deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.28920156
64signal peptide processing (GO:0006465)3.27689941
65rRNA modification (GO:0000154)3.27140650
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.25246576
67intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.25246576
68pseudouridine synthesis (GO:0001522)3.24825394
69dopamine transport (GO:0015872)3.24216880
70nuclear-transcribed mRNA catabolic process (GO:0000956)3.22524490
71spliceosomal snRNP assembly (GO:0000387)3.22408614
72positive regulation of ligase activity (GO:0051351)3.21784908
73signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.21111374
74signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.21111374
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.21111374
76amino acid salvage (GO:0043102)3.20429184
77L-methionine salvage (GO:0071267)3.20429184
78L-methionine biosynthetic process (GO:0071265)3.20429184
79mitochondrial transport (GO:0006839)3.17266512
80deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.16828938
81protein-cofactor linkage (GO:0018065)3.16471735
82fatty acid elongation (GO:0030497)3.13904242
83translational initiation (GO:0006413)3.13557101
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13474866
85negative regulation of ligase activity (GO:0051352)3.13474866
86DNA damage response, detection of DNA damage (GO:0042769)3.13260856
87protein localization to mitochondrion (GO:0070585)3.13048018
88ribonucleoside triphosphate biosynthetic process (GO:0009201)3.11645011
89intracellular protein transmembrane import (GO:0044743)3.10764982
90signal transduction involved in DNA damage checkpoint (GO:0072422)3.09046208
91signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09046208
92purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.06006805
93purine nucleoside monophosphate biosynthetic process (GO:0009127)3.06006805
94nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05800442
95GTP biosynthetic process (GO:0006183)3.05617331
96regulation of oxidative phosphorylation (GO:0002082)3.05142720
97mRNA catabolic process (GO:0006402)3.03928503
98signal transduction involved in cell cycle checkpoint (GO:0072395)3.03757532
99maturation of SSU-rRNA (GO:0030490)3.02006423
100cellular component biogenesis (GO:0044085)3.01088450
101protein targeting to membrane (GO:0006612)3.00613632
102metallo-sulfur cluster assembly (GO:0031163)2.98840913
103iron-sulfur cluster assembly (GO:0016226)2.98840913
104cullin deneddylation (GO:0010388)2.94470511
105regulation of cellular amine metabolic process (GO:0033238)2.93801910
106aerobic respiration (GO:0009060)2.91152107
107protein deneddylation (GO:0000338)2.88209942
108positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83452296
109antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.80774621
110protein complex disassembly (GO:0043241)2.79973133
111cofactor catabolic process (GO:0051187)2.78764125
112nucleoside triphosphate biosynthetic process (GO:0009142)2.76271307
113ribosomal large subunit biogenesis (GO:0042273)2.73288354
114regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70625330
115positive regulation of cellular amine metabolic process (GO:0033240)2.69064581
116regulation of cellular respiration (GO:0043457)2.67625810
117macromolecular complex disassembly (GO:0032984)2.66736086
118peptidyl-histidine modification (GO:0018202)2.62437359
1197-methylguanosine mRNA capping (GO:0006370)2.62377457
120quinone metabolic process (GO:1901661)2.59805565
1217-methylguanosine RNA capping (GO:0009452)2.59510431
122RNA capping (GO:0036260)2.59510431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.50777443
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.86450542
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.63113373
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.41795721
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.07743415
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.95290501
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.81658688
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.37338550
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20264339
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.11951841
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.11426393
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.96838355
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.93820985
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.93664144
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.88609274
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.83277305
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.71940248
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61068859
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55949995
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52874394
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.36590347
22CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.20404844
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12876931
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12316840
25VDR_23849224_ChIP-Seq_CD4+_Human2.11854880
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.10098504
27DCP1A_22483619_ChIP-Seq_HELA_Human2.01934144
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83643814
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81187237
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.80222237
31FOXP3_21729870_ChIP-Seq_TREG_Human1.79546528
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.76418457
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73180231
34XRN2_22483619_ChIP-Seq_HELA_Human1.72135328
35ELK1_19687146_ChIP-ChIP_HELA_Human1.71655000
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67331904
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64644754
38ELK1_22589737_ChIP-Seq_MCF10A_Human1.62728365
39GABP_19822575_ChIP-Seq_HepG2_Human1.62670058
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60825123
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54256489
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51935927
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48415477
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45619351
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44191666
46IRF1_19129219_ChIP-ChIP_H3396_Human1.41258332
47TTF2_22483619_ChIP-Seq_HELA_Human1.41226539
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40037477
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39395502
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39317181
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35604075
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28555419
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28101879
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25974160
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25925606
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20930086
57CTCF_18555785_ChIP-Seq_MESCs_Mouse1.20446459
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16483115
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14717982
60CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13885758
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13763456
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11048790
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.10008001
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09711693
65MYC_18940864_ChIP-ChIP_HL60_Human1.08266999
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07684786
67STAT1_20625510_ChIP-Seq_HELA_Human1.06809364
68VDR_22108803_ChIP-Seq_LS180_Human1.03210811
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02906514
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02866216
71KDM5A_27292631_Chip-Seq_BREAST_Human1.02625313
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00302191
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99716461
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97356320
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95939838
76NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94950613
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93240072
78ZNF274_21170338_ChIP-Seq_K562_Hela0.91158104
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91062343
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90916581
81STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89481455
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89411745
83OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88935973
84YY1_22570637_ChIP-Seq_MALME-3M_Human0.88181480
85* SPI1_23547873_ChIP-Seq_NB4_Human0.88121939
86FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87307884
87TP53_22573176_ChIP-Seq_HFKS_Human0.86462217
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86357915
89SOX2_16153702_ChIP-ChIP_HESCs_Human0.85667003
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85611216
91AR_20517297_ChIP-Seq_VCAP_Human0.84312884
92MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84079434
93* FOXP1_21924763_ChIP-Seq_HESCs_Human0.83572260
94SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82767973
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82364246
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82036229
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.81908284
98CTCF_26484167_Chip-Seq_Bcells_Mouse0.81802855
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81791536
100ERG_20517297_ChIP-Seq_VCAP_Human0.81207893
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80922771
102ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80730340
103BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.80617091
104CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79869780
105SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79689889
106IRF8_22096565_ChIP-ChIP_GC-B_Human0.79412915
107RXR_22158963_ChIP-Seq_LIVER_Mouse0.78980565
108KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78806765
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78338822
110SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78165653
111* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78063051
112HTT_18923047_ChIP-ChIP_STHdh_Human0.78056633
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.77963227
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76608353
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.75522108
116ELF5_23300383_ChIP-Seq_T47D_Human0.74874236
117MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.74277453
118MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.74237717
119PU.1_20513432_ChIP-Seq_Bcells_Mouse0.73862682
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71952514
121ZFX_18555785_ChIP-Seq_MESCs_Mouse0.71504705
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.69752936
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.68844049
124FOXA1_27270436_Chip-Seq_PROSTATE_Human0.68116523
125FOXA1_25329375_ChIP-Seq_VCAP_Human0.68116523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.09805142
2MP0009379_abnormal_foot_pigmentation3.78054770
3MP0001529_abnormal_vocalization3.52683164
4MP0005083_abnormal_biliary_tract3.20222258
5MP0003186_abnormal_redox_activity3.00976902
6MP0006036_abnormal_mitochondrial_physio2.90656386
7MP0001905_abnormal_dopamine_level2.60294760
8MP0003195_calcinosis2.55887216
9MP0008875_abnormal_xenobiotic_pharmacok2.49634277
10MP0008058_abnormal_DNA_repair2.47119135
11MP0001986_abnormal_taste_sensitivity2.38651607
12MP0006035_abnormal_mitochondrial_morpho2.36975533
13MP0003724_increased_susceptibility_to2.33335623
14MP0005085_abnormal_gallbladder_physiolo2.31349350
15MP0002139_abnormal_hepatobiliary_system2.21976375
16MP0002938_white_spotting2.18259917
17MP0010030_abnormal_orbit_morphology2.18034325
18MP0003880_abnormal_central_pattern2.08003088
19MP0005075_abnormal_melanosome_morpholog2.05912222
20MP0002102_abnormal_ear_morphology2.04598414
21MP0005365_abnormal_bile_salt2.02682149
22MP0002132_abnormal_respiratory_system1.99212643
23MP0004142_abnormal_muscle_tone1.98124950
24MP0006072_abnormal_retinal_apoptosis1.96840682
25MP0004147_increased_porphyrin_level1.90714962
26MP0003786_premature_aging1.90653781
27MP0009785_altered_susceptibility_to1.90437653
28MP0005360_urolithiasis1.81416768
29MP0002148_abnormal_hypersensitivity_rea1.81297488
30MP0001764_abnormal_homeostasis1.68389186
31MP0005451_abnormal_body_composition1.68053826
32MP0005058_abnormal_lysosome_morphology1.67331027
33MP0006082_CNS_inflammation1.61360251
34MP0006276_abnormal_autonomic_nervous1.57471449
35MP0002837_dystrophic_cardiac_calcinosis1.52041816
36MP0004043_abnormal_pH_regulation1.48599562
37MP0005408_hypopigmentation1.48488659
38MP0000372_irregular_coat_pigmentation1.47099354
39MP0004381_abnormal_hair_follicle1.46818458
40MP0008995_early_reproductive_senescence1.45962056
41MP0005636_abnormal_mineral_homeostasis1.45569010
42MP0003136_yellow_coat_color1.41746673
43MP0005025_abnormal_response_to1.38783519
44MP0005332_abnormal_amino_acid1.38513795
45MP0003011_delayed_dark_adaptation1.38393332
46MP0002876_abnormal_thyroid_physiology1.36389270
47MP0005551_abnormal_eye_electrophysiolog1.35775466
48MP0008872_abnormal_physiological_respon1.35643631
49MP0002653_abnormal_ependyma_morphology1.35365729
50MP0002163_abnormal_gland_morphology1.35003317
51MP0005253_abnormal_eye_physiology1.32683350
52MP0005266_abnormal_metabolism1.32423576
53MP0002277_abnormal_respiratory_mucosa1.30324600
54MP0003656_abnormal_erythrocyte_physiolo1.29204019
55MP0002090_abnormal_vision1.28843204
56MP0001485_abnormal_pinna_reflex1.25936242
57MP0002736_abnormal_nociception_after1.25615842
58MP0005171_absent_coat_pigmentation1.24903091
59MP0003436_decreased_susceptibility_to1.24890553
60MP0001835_abnormal_antigen_presentation1.24467125
61MP0002095_abnormal_skin_pigmentation1.24211145
62MP0005000_abnormal_immune_tolerance1.21013556
63MP0002332_abnormal_exercise_endurance1.19751407
64MP0001666_abnormal_nutrient_absorption1.19343819
65MP0005671_abnormal_response_to1.18566140
66MP0005376_homeostasis/metabolism_phenot1.18067328
67MP0005379_endocrine/exocrine_gland_phen1.16952000
68MP0008469_abnormal_protein_level1.16345103
69MP0004133_heterotaxia1.15460760
70MP0005084_abnormal_gallbladder_morpholo1.14540518
71MP0009840_abnormal_foam_cell1.14014565
72MP0003718_maternal_effect1.13410053
73MP0009333_abnormal_splenocyte_physiolog1.13315387
74MP0005410_abnormal_fertilization1.08327729
75MP0005584_abnormal_enzyme/coenzyme_acti1.07872044
76MP0001293_anophthalmia1.07173305
77MP0006292_abnormal_olfactory_placode1.06904483
78MP0002735_abnormal_chemical_nociception1.04741864
79MP0002419_abnormal_innate_immunity1.04103278
80MP0000920_abnormal_myelination1.03909727
81MP0005319_abnormal_enzyme/_coenzyme1.03482451
82MP0001324_abnormal_eye_pigmentation1.00343934
83MP0008932_abnormal_embryonic_tissue0.98021168
84MP0004782_abnormal_surfactant_physiolog0.97164371
85MP0003693_abnormal_embryo_hatching0.97117721
86MP0003646_muscle_fatigue0.95711632
87MP0004742_abnormal_vestibular_system0.93602109
88MP0001727_abnormal_embryo_implantation0.91422838
89MP0008873_increased_physiological_sensi0.91300051
90MP0004957_abnormal_blastocyst_morpholog0.91179702
91MP0001970_abnormal_pain_threshold0.91152256
92MP0003938_abnormal_ear_development0.90915738
93MP0009643_abnormal_urine_homeostasis0.90910744
94MP0009046_muscle_twitch0.90394449
95MP0004019_abnormal_vitamin_homeostasis0.90166828
96MP0008260_abnormal_autophagy0.89305089
97MP0002282_abnormal_trachea_morphology0.89258995
98MP0002272_abnormal_nervous_system0.88411618
99MP0000026_abnormal_inner_ear0.88208703
100MP0010386_abnormal_urinary_bladder0.87053586
101MP0005377_hearing/vestibular/ear_phenot0.86375537
102MP0003878_abnormal_ear_physiology0.86375537
103MP0005646_abnormal_pituitary_gland0.85913122
104MP0000631_abnormal_neuroendocrine_gland0.83681237
105MP0001968_abnormal_touch/_nociception0.82779155
106MP0008789_abnormal_olfactory_epithelium0.82375095
107MP0001845_abnormal_inflammatory_respons0.80689737
108MP0005394_taste/olfaction_phenotype0.80143933
109MP0005499_abnormal_olfactory_system0.80143933
110MP0002723_abnormal_immune_serum0.79269084
111MP0000358_abnormal_cell_content/0.78086562
112MP0008877_abnormal_DNA_methylation0.77811711
113MP0001542_abnormal_bone_strength0.77621544
114MP0009697_abnormal_copulation0.77558335
115MP0000343_altered_response_to0.76994983
116MP0005174_abnormal_tail_pigmentation0.76193433
117MP0005195_abnormal_posterior_eye0.75839717
118MP0001663_abnormal_digestive_system0.75575079
119MP0005535_abnormal_body_temperature0.74555139
120MP0000049_abnormal_middle_ear0.73808348
121MP0003638_abnormal_response/metabolism_0.73440167
122MP0002822_catalepsy0.73296361
123MP0003137_abnormal_impulse_conducting0.72894927
124MP0002064_seizures0.72766475
125MP0001756_abnormal_urination0.72611714
126MP0003183_abnormal_peptide_metabolism0.71099416
127MP0003329_amyloid_beta_deposits0.70959212
128MP0005645_abnormal_hypothalamus_physiol0.70832036
129MP0009764_decreased_sensitivity_to0.70569492
130MP0003077_abnormal_cell_cycle0.70387408
131MP0002751_abnormal_autonomic_nervous0.69505607
132MP0009745_abnormal_behavioral_response0.67234402
133MP0001853_heart_inflammation0.67194655
134MP0003121_genomic_imprinting0.66785037
135MP0002733_abnormal_thermal_nociception0.66406802
136MP0001664_abnormal_digestion0.66046595
137MP0002638_abnormal_pupillary_reflex0.65742557
138MP0005310_abnormal_salivary_gland0.65595369
139MP0001984_abnormal_olfaction0.65116519
140MP0002420_abnormal_adaptive_immunity0.64702327
141MP0010094_abnormal_chromosome_stability0.63756169
142MP0002210_abnormal_sex_determination0.63101499
143MP0002295_abnormal_pulmonary_circulatio0.62785014

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.59835530
2Abnormal mitochondria in muscle tissue (HP:0008316)6.07934161
3Mitochondrial inheritance (HP:0001427)5.81028840
4Acute encephalopathy (HP:0006846)5.61372099
5Progressive macrocephaly (HP:0004481)5.31140750
6Hepatocellular necrosis (HP:0001404)5.29439530
7Increased CSF lactate (HP:0002490)5.03090968
8Hepatic necrosis (HP:0002605)4.86921133
93-Methylglutaconic aciduria (HP:0003535)4.60751765
10Increased hepatocellular lipid droplets (HP:0006565)4.37838936
11Renal Fanconi syndrome (HP:0001994)4.21934269
12Cerebral edema (HP:0002181)4.19192930
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.13738752
14Decreased activity of mitochondrial respiratory chain (HP:0008972)4.12510915
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.12510915
16Abnormality of cells of the erythroid lineage (HP:0012130)4.06106101
17Lipid accumulation in hepatocytes (HP:0006561)4.03818345
18Abnormality of glycolysis (HP:0004366)3.86857181
19Increased serum pyruvate (HP:0003542)3.86857181
20Abnormal number of erythroid precursors (HP:0012131)3.77289168
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.74354516
22Increased intramyocellular lipid droplets (HP:0012240)3.68610590
23Respiratory failure (HP:0002878)3.55992701
24Lactic acidosis (HP:0003128)3.52107255
25Exercise intolerance (HP:0003546)3.46148002
26Increased serum lactate (HP:0002151)3.41922877
27Leukodystrophy (HP:0002415)3.38594632
28Abnormality of aromatic amino acid family metabolism (HP:0004338)3.30344986
29Optic disc pallor (HP:0000543)3.25661987
30Increased muscle lipid content (HP:0009058)3.25109522
31Exertional dyspnea (HP:0002875)3.20975317
32Type I transferrin isoform profile (HP:0003642)2.86680600
33Lethargy (HP:0001254)2.81481555
34Macrocytic anemia (HP:0001972)2.74564093
35Abnormality of renal resorption (HP:0011038)2.74443955
36Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.72529106
37Respiratory difficulties (HP:0002880)2.68704988
38Congenital, generalized hypertrichosis (HP:0004540)2.66637146
39Reticulocytopenia (HP:0001896)2.64972632
40Hypothermia (HP:0002045)2.64045188
41Parakeratosis (HP:0001036)2.58056789
42CNS demyelination (HP:0007305)2.54059669
43Abnormality of urine glucose concentration (HP:0011016)2.48694589
44Glycosuria (HP:0003076)2.48694589
45Reduced antithrombin III activity (HP:0001976)2.41129130
46Hyperglycinemia (HP:0002154)2.34472273
47Hyperphosphaturia (HP:0003109)2.32456578
48Vacuolated lymphocytes (HP:0001922)2.31825558
49Congenital ichthyosiform erythroderma (HP:0007431)2.31108287
50Abnormality of the anterior horn cell (HP:0006802)2.29557225
51Degeneration of anterior horn cells (HP:0002398)2.29557225
52Emotional lability (HP:0000712)2.27975901
53Microvesicular hepatic steatosis (HP:0001414)2.25993965
54Neuroendocrine neoplasm (HP:0100634)2.24345714
55Oral leukoplakia (HP:0002745)2.24248457
56Pallor (HP:0000980)2.23673662
57Generalized aminoaciduria (HP:0002909)2.22279173
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.21082373
59Dicarboxylic aciduria (HP:0003215)2.21082373
60Pancytopenia (HP:0001876)2.14411789
61Cerebral hypomyelination (HP:0006808)2.12324174
62Vomiting (HP:0002013)2.07190825
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06823439
64Abnormal protein N-linked glycosylation (HP:0012347)2.06823439
65Abnormal protein glycosylation (HP:0012346)2.06823439
66Abnormal glycosylation (HP:0012345)2.06823439
67X-linked dominant inheritance (HP:0001423)2.06439636
68Methylmalonic aciduria (HP:0012120)2.04277093
69Abnormality of midbrain morphology (HP:0002418)2.00943918
70Molar tooth sign on MRI (HP:0002419)2.00943918
71Purpura (HP:0000979)2.00067237
72Pancreatic cysts (HP:0001737)1.99984036
73Nausea (HP:0002018)1.98988203
74Poor suck (HP:0002033)1.98565404
75Opisthotonus (HP:0002179)1.98047043
76Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97354478
77Petechiae (HP:0000967)1.96168276
78Colon cancer (HP:0003003)1.95254417
79Medial flaring of the eyebrow (HP:0010747)1.94342315
80Abnormality of placental membranes (HP:0011409)1.93914718
81Amniotic constriction ring (HP:0009775)1.93914718
82Gliosis (HP:0002171)1.90590613
83Abnormal pupillary function (HP:0007686)1.90232447
84Pheochromocytoma (HP:0002666)1.89455628
85Multiple enchondromatosis (HP:0005701)1.88269733
86Abnormal urine phosphate concentration (HP:0012599)1.87875852
87True hermaphroditism (HP:0010459)1.87544961
88Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86516948
89Spastic paraparesis (HP:0002313)1.85993848
90Retinal dysplasia (HP:0007973)1.85345926
91Axonal loss (HP:0003447)1.83615166
92Pancreatic fibrosis (HP:0100732)1.83007826
93Aplastic anemia (HP:0001915)1.81942052
94Methylmalonic acidemia (HP:0002912)1.81853233
95Renal tubular dysfunction (HP:0000124)1.81656388
96Prolonged partial thromboplastin time (HP:0003645)1.80581098
97Concave nail (HP:0001598)1.78555252
98Esophageal neoplasm (HP:0100751)1.77375703
99Neoplasm of head and neck (HP:0012288)1.77375703
100Myokymia (HP:0002411)1.77208946
101Abnormal hemoglobin (HP:0011902)1.73481511
102Poor head control (HP:0002421)1.72805695
103Sparse eyelashes (HP:0000653)1.72582235
104Testicular atrophy (HP:0000029)1.71350000
105Type II lissencephaly (HP:0007260)1.69394385
106Aplasia/hypoplasia of the uterus (HP:0008684)1.69140474
107Abnormality of serum amino acid levels (HP:0003112)1.68790900
108Blindness (HP:0000618)1.68769691
109Limb dystonia (HP:0002451)1.67520068
110Rough bone trabeculation (HP:0100670)1.65532582
111Abnormality of fatty-acid metabolism (HP:0004359)1.64379064
112Nephronophthisis (HP:0000090)1.64362606
113Septo-optic dysplasia (HP:0100842)1.63683091
114Delusions (HP:0000746)1.63626465
115Brushfield spots (HP:0001088)1.62563807
116Delayed CNS myelination (HP:0002188)1.61472872
117Hepatosplenomegaly (HP:0001433)1.57627521
118Cleft eyelid (HP:0000625)1.56068840
119Hypokinesia (HP:0002375)1.55907464
120Abolished electroretinogram (ERG) (HP:0000550)1.55350547
121Sclerocornea (HP:0000647)1.53830026
122Abnormality of the heme biosynthetic pathway (HP:0010472)1.50845647
123Abnormal gallbladder physiology (HP:0012438)1.50337381
124Cholecystitis (HP:0001082)1.50337381
125Increased IgM level (HP:0003496)1.50313118
126Progressive neurologic deterioration (HP:0002344)1.49327825
127Metabolic acidosis (HP:0001942)1.47877341
128Steatorrhea (HP:0002570)1.47583807
129Sensory axonal neuropathy (HP:0003390)1.47298808
130Hypobetalipoproteinemia (HP:0003563)1.47289403

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.62393278
2STK163.66754281
3MAP3K123.64717472
4NME23.61776663
5NME13.06024552
6ARAF2.93114275
7PIM22.85177837
8ZAK2.73931813
9BCKDK2.47607890
10GRK52.37595975
11BUB12.27895897
12EIF2AK32.22032573
13TESK22.21647244
14NUAK12.10734346
15PBK2.09286713
16MST42.08027396
17CASK1.93152635
18MYLK1.90065211
19CDK191.86388081
20ADRBK21.84220089
21VRK11.79339928
22MAP4K21.78732051
23GRK71.68031079
24OXSR11.58344326
25LIMK11.58028468
26MAPKAPK51.53833463
27EPHB21.51088858
28KDR1.46805598
29BRAF1.39725815
30MUSK1.38393418
31WNK31.35778868
32GRK61.35128065
33STK391.32907114
34NEK11.23237375
35CDC71.22737713
36WEE11.22095156
37PDK21.20704039
38ABL21.20380709
39TRIM281.15829870
40BLK1.15611115
41FGR1.14065867
42MST1R1.10709545
43BMPR1B1.08599264
44PLK31.08317313
45EIF2AK11.04104713
46MATK1.03421729
47GRK11.02259009
48DYRK20.99523161
49ERN10.99466987
50CSNK1G20.98033791
51TESK10.97063242
52TSSK60.96367497
53TXK0.94373569
54IRAK30.91067902
55ADRBK10.89822013
56DAPK10.89314607
57MAPK150.88995494
58IRAK40.88729535
59MARK30.87245493
60BMPR20.86679865
61PINK10.85762898
62CSF1R0.84310311
63MAPKAPK30.84182841
64BCR0.81961691
65SIK30.81246245
66CAMK2B0.80330359
67DYRK30.80112264
68CDK80.78385785
69CSNK1G30.76942385
70TNIK0.75920807
71DAPK30.75717930
72CSNK1A1L0.75669709
73TAF10.75642861
74MAP3K110.73704387
75RPS6KA50.72983365
76SYK0.72321418
77PLK10.71719109
78PASK0.69725150
79PAK40.68815558
80SRPK10.67155095
81LYN0.66577238
82RIPK40.64595569
83PRKCG0.63018546
84ILK0.62763812
85WNK40.62702605
86IRAK20.61593026
87AURKB0.61250005
88CAMK2G0.59951938
89CAMK2D0.59420279
90KIT0.56999501
91CCNB10.56181275
92AURKA0.54300251
93MAPK40.53780624
94TEC0.53463506
95PAK10.52797643
96AKT30.52792700
97TGFBR10.51784421
98UHMK10.51380258
99CSNK2A10.51314559
100TLK10.51045243
101RPS6KB20.51038057
102PLK40.50444890
103YES10.50339987
104TAOK20.49588431
105MOS0.49316655
106PLK20.48688653
107BRSK20.48550585
108LRRK20.48281787
109PRKCD0.47274790
110EIF2AK20.46636052
111IKBKB0.46522586
112CSNK2A20.45851967
113CAMK2A0.45304792
114TTK0.45221923
115ERBB40.44952979
116TYK20.44605382
117INSRR0.44352506
118BTK0.43402749
119MAP2K70.43377863
120RPS6KA40.43185947
121TNK20.42606925
122MAP2K20.41746389
123PRKG20.41630300
124TAOK30.41591517
125PRKACA0.40395863
126PRKCI0.39286573
127TBK10.38015589
128ATR0.37097716
129EPHA40.35919697
130MAP4K10.33799100
131CSNK1G10.33771745
132CHEK20.33381755
133TIE10.32276970
134CSNK1A10.30889698
135MINK10.29787221
136PRKCE0.29672881
137ACVR1B0.28919136
138MAPK130.27792553
139ERBB30.25869094

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.16562271
2Parkinsons disease_Homo sapiens_hsa050124.29728195
3Ribosome_Homo sapiens_hsa030104.16714945
4Proteasome_Homo sapiens_hsa030503.62497062
5Alzheimers disease_Homo sapiens_hsa050103.18373876
6Protein export_Homo sapiens_hsa030603.03822755
7Huntingtons disease_Homo sapiens_hsa050162.94321841
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.80764885
9RNA polymerase_Homo sapiens_hsa030202.36637796
10Fatty acid elongation_Homo sapiens_hsa000622.22667803
11Folate biosynthesis_Homo sapiens_hsa007902.16408013
12Sulfur metabolism_Homo sapiens_hsa009201.76227804
13Sulfur relay system_Homo sapiens_hsa041221.71817151
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69700354
15Collecting duct acid secretion_Homo sapiens_hsa049661.61087564
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51668562
17Pyrimidine metabolism_Homo sapiens_hsa002401.48878631
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45981770
19Steroid biosynthesis_Homo sapiens_hsa001001.38927101
20Cardiac muscle contraction_Homo sapiens_hsa042601.37058068
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34037910
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33542660
23Histidine metabolism_Homo sapiens_hsa003401.32918164
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27350845
25Glutathione metabolism_Homo sapiens_hsa004801.23334359
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22548194
27Pyruvate metabolism_Homo sapiens_hsa006201.20175726
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16510482
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16343202
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15298769
31Chemical carcinogenesis_Homo sapiens_hsa052041.14639108
32Vibrio cholerae infection_Homo sapiens_hsa051101.13335014
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13300928
34Peroxisome_Homo sapiens_hsa041461.10737526
35Phenylalanine metabolism_Homo sapiens_hsa003601.06944090
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.02915298
37Metabolic pathways_Homo sapiens_hsa011001.01752629
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00586602
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99128725
40Pentose phosphate pathway_Homo sapiens_hsa000300.95936902
41Tyrosine metabolism_Homo sapiens_hsa003500.95596571
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93887904
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93640813
44Butanoate metabolism_Homo sapiens_hsa006500.92705816
45Propanoate metabolism_Homo sapiens_hsa006400.91605425
46Fanconi anemia pathway_Homo sapiens_hsa034600.90722863
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.88075682
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88045610
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87875378
50Arachidonic acid metabolism_Homo sapiens_hsa005900.87668986
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.85503884
52DNA replication_Homo sapiens_hsa030300.85003892
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84650299
54Carbon metabolism_Homo sapiens_hsa012000.83477738
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81954581
56RNA transport_Homo sapiens_hsa030130.80430024
57Linoleic acid metabolism_Homo sapiens_hsa005910.80137583
58Rheumatoid arthritis_Homo sapiens_hsa053230.79500640
59One carbon pool by folate_Homo sapiens_hsa006700.79286943
60Homologous recombination_Homo sapiens_hsa034400.75890116
61Other glycan degradation_Homo sapiens_hsa005110.74793775
62Arginine and proline metabolism_Homo sapiens_hsa003300.73757033
63beta-Alanine metabolism_Homo sapiens_hsa004100.73400625
64Vitamin B6 metabolism_Homo sapiens_hsa007500.72907668
65Tryptophan metabolism_Homo sapiens_hsa003800.71966483
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69451422
67Fructose and mannose metabolism_Homo sapiens_hsa000510.69358808
68Mismatch repair_Homo sapiens_hsa034300.67938988
69Ether lipid metabolism_Homo sapiens_hsa005650.66905332
70Purine metabolism_Homo sapiens_hsa002300.66801440
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.64845289
72Spliceosome_Homo sapiens_hsa030400.63376250
73Phagosome_Homo sapiens_hsa041450.63033249
74Regulation of autophagy_Homo sapiens_hsa041400.62870098
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61959575
76Nucleotide excision repair_Homo sapiens_hsa034200.61626642
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60746127
78Phototransduction_Homo sapiens_hsa047440.60606105
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53832639
80Biosynthesis of amino acids_Homo sapiens_hsa012300.53625640
81Basal transcription factors_Homo sapiens_hsa030220.52678231
82Fatty acid metabolism_Homo sapiens_hsa012120.51672983
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.50181827
84Retinol metabolism_Homo sapiens_hsa008300.49212469
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47621100
86Galactose metabolism_Homo sapiens_hsa000520.46933370
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46195443
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.45696637
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43830590
90Non-homologous end-joining_Homo sapiens_hsa034500.43147585
91Staphylococcus aureus infection_Homo sapiens_hsa051500.42308231
92Fatty acid degradation_Homo sapiens_hsa000710.42263641
93Nitrogen metabolism_Homo sapiens_hsa009100.40651991
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39868291
95Mineral absorption_Homo sapiens_hsa049780.39217500
96Asthma_Homo sapiens_hsa053100.36269101
97Base excision repair_Homo sapiens_hsa034100.36051002
98N-Glycan biosynthesis_Homo sapiens_hsa005100.35880484
99Systemic lupus erythematosus_Homo sapiens_hsa053220.35721858
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34320484
101Caffeine metabolism_Homo sapiens_hsa002320.32851822
102RNA degradation_Homo sapiens_hsa030180.31961034
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.31399981
104Fat digestion and absorption_Homo sapiens_hsa049750.30793843
105Sphingolipid metabolism_Homo sapiens_hsa006000.29376760
106Complement and coagulation cascades_Homo sapiens_hsa046100.29301923
107Graft-versus-host disease_Homo sapiens_hsa053320.28882280
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28852759
109Lysosome_Homo sapiens_hsa041420.27660827
110Epstein-Barr virus infection_Homo sapiens_hsa051690.26855873
111Antigen processing and presentation_Homo sapiens_hsa046120.26281817
112Vitamin digestion and absorption_Homo sapiens_hsa049770.26006605
113Allograft rejection_Homo sapiens_hsa053300.24179407
114Synaptic vesicle cycle_Homo sapiens_hsa047210.23078154
115Autoimmune thyroid disease_Homo sapiens_hsa053200.21706012
116Legionellosis_Homo sapiens_hsa051340.21386344

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