LAMTOR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.64305757
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64283779
3neutrophil activation involved in immune response (GO:0002283)4.59961541
4ATP synthesis coupled proton transport (GO:0015986)4.54513676
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.54513676
6presynaptic membrane assembly (GO:0097105)4.51914910
7DNA double-strand break processing (GO:0000729)4.48602925
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.29057721
9platelet dense granule organization (GO:0060155)4.25193850
10intraciliary transport (GO:0042073)4.17616572
11phagosome maturation (GO:0090382)4.17202222
12presynaptic membrane organization (GO:0097090)4.04646828
13respiratory electron transport chain (GO:0022904)3.94848197
14cytochrome complex assembly (GO:0017004)3.90716191
15electron transport chain (GO:0022900)3.84210321
16protein neddylation (GO:0045116)3.81654810
17protein complex biogenesis (GO:0070271)3.81098156
18protein localization to cilium (GO:0061512)3.78101695
19eosinophil chemotaxis (GO:0048245)3.76621822
20superoxide anion generation (GO:0042554)3.70096581
21energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.69921159
22ATP hydrolysis coupled proton transport (GO:0015991)3.69921159
23signal peptide processing (GO:0006465)3.59209490
24transferrin transport (GO:0033572)3.56287909
25antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.54699293
26NADH dehydrogenase complex assembly (GO:0010257)3.54395835
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54395835
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.54395835
29protein deneddylation (GO:0000338)3.49060671
30cullin deneddylation (GO:0010388)3.47147248
31neuron cell-cell adhesion (GO:0007158)3.46303308
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.45765243
33water-soluble vitamin biosynthetic process (GO:0042364)3.42474838
34respiratory burst (GO:0045730)3.41359280
35chaperone-mediated protein transport (GO:0072321)3.39932171
36eosinophil migration (GO:0072677)3.39913173
37proteasome assembly (GO:0043248)3.39683173
38neuron fate determination (GO:0048664)3.37867139
39postsynaptic membrane organization (GO:0001941)3.36169973
40respiratory chain complex IV assembly (GO:0008535)3.34346890
41epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33473805
42neural tube formation (GO:0001841)3.32101392
43pyrimidine nucleobase catabolic process (GO:0006208)3.30746928
44response to peptidoglycan (GO:0032494)3.28093468
45mitochondrial respiratory chain complex assembly (GO:0033108)3.27491641
46ferric iron transport (GO:0015682)3.26262498
47trivalent inorganic cation transport (GO:0072512)3.26262498
48cilium morphogenesis (GO:0060271)3.25949071
49epithelial cilium movement (GO:0003351)3.25600393
50hydrogen peroxide biosynthetic process (GO:0050665)3.20938749
51behavioral response to nicotine (GO:0035095)3.20327048
52regulation of cilium movement (GO:0003352)3.18369451
53protein-cofactor linkage (GO:0018065)3.13844609
54endosome to melanosome transport (GO:0035646)3.12005708
55endosome to pigment granule transport (GO:0043485)3.12005708
56nonmotile primary cilium assembly (GO:0035058)3.09253185
57cellular response to zinc ion (GO:0071294)3.07705615
58production of molecular mediator involved in inflammatory response (GO:0002532)3.02653959
59heart process (GO:0003015)3.00732314
60heart contraction (GO:0060047)3.00732314
61cellular response to interferon-beta (GO:0035458)2.99557483
62nucleobase catabolic process (GO:0046113)2.97904474
63reactive oxygen species biosynthetic process (GO:1903409)2.96596800
64negative regulation of mast cell activation (GO:0033004)2.96259551
65antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.96074980
66axoneme assembly (GO:0035082)2.93149205
67positive regulation of monocyte chemotaxis (GO:0090026)2.92692873
68C4-dicarboxylate transport (GO:0015740)2.90779937
69limb bud formation (GO:0060174)2.89782200
70glycosphingolipid biosynthetic process (GO:0006688)2.88440266
71immunoglobulin mediated immune response (GO:0016064)2.87909511
72gamma-aminobutyric acid transport (GO:0015812)2.87275814
73sequestering of actin monomers (GO:0042989)2.85068697
74neutrophil activation (GO:0042119)2.82885327
75hydrogen ion transmembrane transport (GO:1902600)2.82500894
76modulation by symbiont of host defense response (GO:0052031)2.80934434
77modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.80934434
78modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.80934434
79positive regulation by organism of defense response of other organism involved in symbiotic interact2.80934434
80modulation by symbiont of host immune response (GO:0052553)2.80934434
81positive regulation by symbiont of host defense response (GO:0052509)2.80934434
82cilium organization (GO:0044782)2.80604430
83retinal ganglion cell axon guidance (GO:0031290)2.80333135
84granulocyte activation (GO:0036230)2.80231657
85anterograde synaptic vesicle transport (GO:0048490)2.78146933
86intracellular pH reduction (GO:0051452)2.75060130
87cilium assembly (GO:0042384)2.75003393
88oxidative phosphorylation (GO:0006119)2.74191511
89ribonucleoprotein complex disassembly (GO:0032988)2.73096913
90detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.72475005
91response to interferon-beta (GO:0035456)2.72169388
92regulation of heat generation (GO:0031650)2.70369103
93organelle disassembly (GO:1903008)2.68695444
94DNA integration (GO:0015074)2.67874135
95regulation of T-helper 1 cell differentiation (GO:0045625)2.67785708
96inositol phosphate catabolic process (GO:0071545)2.67228164
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.66938906
98DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.65787522
99regulation of hexokinase activity (GO:1903299)2.65652559
100regulation of glucokinase activity (GO:0033131)2.65652559
101photoreceptor cell maintenance (GO:0045494)2.65621857
102negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.64991361
103regulation of feeding behavior (GO:0060259)2.64005408
104L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.62398576
105regulation of cellular amino acid metabolic process (GO:0006521)2.62246174
106proton transport (GO:0015992)2.61681612
107negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.61657974
108pH reduction (GO:0045851)2.58902077
109positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.57670616
110mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.57670616
1117-methylguanosine mRNA capping (GO:0006370)2.57528311
112iron-sulfur cluster assembly (GO:0016226)2.56870596
113metallo-sulfur cluster assembly (GO:0031163)2.56870596
114signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.56819211
115intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.56819211
116cilium movement (GO:0003341)2.55829044
117hydrogen transport (GO:0006818)2.55655837
118positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.54639586
119behavioral response to ethanol (GO:0048149)2.53790401
120signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.53168054
121signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.53168054
122signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.53168054
123dopamine transport (GO:0015872)2.52405003
1247-methylguanosine RNA capping (GO:0009452)2.51490610
125RNA capping (GO:0036260)2.51490610
126myeloid dendritic cell activation (GO:0001773)2.51321764
127regulation of meiosis I (GO:0060631)2.50904080
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.49664181
129negative regulation of cytosolic calcium ion concentration (GO:0051481)2.49485755
130regulation of fever generation (GO:0031620)2.48910707
131reflex (GO:0060004)2.48869700
132prenylation (GO:0097354)2.48844629
133protein prenylation (GO:0018342)2.48844629
134regulation of mast cell activation (GO:0033003)2.47707209
135aerobic respiration (GO:0009060)2.47442142
136G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.45499405
137negative regulation of transcription regulatory region DNA binding (GO:2000678)2.45350571
138positive regulation of interferon-alpha production (GO:0032727)2.44961854
139fatty acid elongation (GO:0030497)2.44582042
140RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.44558520
141tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.44558520
142peptidyl-histidine modification (GO:0018202)2.44347682
143myeloid dendritic cell differentiation (GO:0043011)2.44209302
144cellular response to thyroid hormone stimulus (GO:0097067)2.43112066
145regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.40967161
146retinal rod cell development (GO:0046548)2.40864270
147positive regulation of antigen processing and presentation (GO:0002579)2.40211322
148cellular ketone body metabolic process (GO:0046950)2.39604643
149DNA demethylation (GO:0080111)2.39333045
150positive regulation of mast cell degranulation (GO:0043306)2.39222043
151positive regulation of mast cell activation involved in immune response (GO:0033008)2.39222043
152regulation of mononuclear cell migration (GO:0071675)2.38870195
153nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.38686124
154neurotransmitter uptake (GO:0001504)2.38542636
155melanosome transport (GO:0032402)2.37738395
156positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.37095731
157DNA damage response, detection of DNA damage (GO:0042769)2.37053348
158proline transport (GO:0015824)2.36552609
159axonal fasciculation (GO:0007413)2.35824441
160positive regulation of mitochondrial fission (GO:0090141)2.35816104
161regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.35721625
162regulation of respiratory system process (GO:0044065)2.35273540
163regulation of mast cell degranulation (GO:0043304)2.35134494
164regulation of dendritic cell antigen processing and presentation (GO:0002604)2.34898280
165exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.34346969
166positive regulation of lymphocyte migration (GO:2000403)2.34225037
167GPI anchor metabolic process (GO:0006505)2.34178823
168establishment of melanosome localization (GO:0032401)2.33933095
169signal transduction involved in DNA integrity checkpoint (GO:0072401)2.33884893
170signal transduction involved in DNA damage checkpoint (GO:0072422)2.33884893
171kidney morphogenesis (GO:0060993)2.33868925
172regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.33137596
173preassembly of GPI anchor in ER membrane (GO:0016254)2.33099076
174peptidyl-cysteine modification (GO:0018198)2.32777719
175establishment of protein localization to mitochondrial membrane (GO:0090151)2.32615857
176inner ear receptor stereocilium organization (GO:0060122)2.31944783
177signal transduction involved in cell cycle checkpoint (GO:0072395)2.31444852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.16845197
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.41131041
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.07665316
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.80010773
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.59388416
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.21850345
7ZNF274_21170338_ChIP-Seq_K562_Hela3.11082944
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.00866640
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76019695
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.71686377
11ELK1_19687146_ChIP-ChIP_HELA_Human2.64610429
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51293285
13SRF_21415370_ChIP-Seq_HL-1_Mouse2.44761786
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.38957167
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30415173
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29227019
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.25303866
18EWS_26573619_Chip-Seq_HEK293_Human2.23162115
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.23071554
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20501249
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.17176916
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.15281415
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08272020
24HOXB4_20404135_ChIP-ChIP_EML_Mouse2.07033911
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06451063
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06352822
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03023151
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.00021197
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97495687
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96910641
31VDR_22108803_ChIP-Seq_LS180_Human1.95246549
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.95207911
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93790610
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89031668
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88697752
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86434035
37EZH2_22144423_ChIP-Seq_EOC_Human1.85755889
38VDR_23849224_ChIP-Seq_CD4+_Human1.83121458
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76397733
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76143019
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73950437
42DCP1A_22483619_ChIP-Seq_HELA_Human1.73438282
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70920883
44SMAD4_21799915_ChIP-Seq_A2780_Human1.68356552
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67456971
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64034318
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.62029872
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62005013
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61631710
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.61198960
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60540394
52SPI1_23547873_ChIP-Seq_NB4_Human1.59913229
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59459299
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58292778
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58258634
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56880790
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56452956
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53267397
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50510422
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50025337
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48869573
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48151407
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.47960930
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.47337838
65GBX2_23144817_ChIP-Seq_PC3_Human1.44619770
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44479905
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.44354015
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.43942226
69BCAT_22108803_ChIP-Seq_LS180_Human1.43900010
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43558445
71CBP_20019798_ChIP-Seq_JUKART_Human1.43558445
72AR_25329375_ChIP-Seq_VCAP_Human1.42797162
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42718663
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41474490
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41474490
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41157717
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.40665981
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39392100
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37929616
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37072301
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.36306956
82E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35466543
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34292598
84FUS_26573619_Chip-Seq_HEK293_Human1.32536782
85STAT3_23295773_ChIP-Seq_U87_Human1.31202839
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31049706
87TAF15_26573619_Chip-Seq_HEK293_Human1.31014197
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30700498
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29880554
90P53_22387025_ChIP-Seq_ESCs_Mouse1.29835919
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29393679
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.29109543
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28816807
94NANOG_19829295_ChIP-Seq_ESCs_Human1.28341720
95SOX2_19829295_ChIP-Seq_ESCs_Human1.28341720
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28080199
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27779826
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27465542
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27411324
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25960039
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25311244
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24859444
103RNF2_27304074_Chip-Seq_NSC_Mouse1.24042721
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23525913
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23476589
106TFEB_21752829_ChIP-Seq_HELA_Human1.20530915
107POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18473431
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.18304939
109MYC_18940864_ChIP-ChIP_HL60_Human1.18016430
110TCF4_22108803_ChIP-Seq_LS180_Human1.17531111
111TP53_22573176_ChIP-Seq_HFKS_Human1.17473567
112SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17328637
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.17263235
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16986443
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16986443
116CRX_20693478_ChIP-Seq_RETINA_Mouse1.16826594
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16498813
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15547266
119RUNX2_22187159_ChIP-Seq_PCA_Human1.14088352
120GATA3_26560356_Chip-Seq_TH2_Human1.13879922
121TCF4_23295773_ChIP-Seq_U87_Human1.13624827
122CMYC_18555785_Chip-Seq_ESCs_Mouse1.13246346
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13144956
124MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12995814
125CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12752466
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12381287
127GATA1_22025678_ChIP-Seq_K562_Human1.12225439
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11625687
129EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10272029
130CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09868026
131P300_18555785_Chip-Seq_ESCs_Mouse1.09805433
132FOXP3_21729870_ChIP-Seq_TREG_Human1.08648854
133IRF1_19129219_ChIP-ChIP_H3396_Human1.08618002
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.07934591
135MYC_18555785_ChIP-Seq_MESCs_Mouse1.06892121
136MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06006721
137BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05509777
138TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05405422
139KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04944968
140CDX2_22108803_ChIP-Seq_LS180_Human1.04237480
141STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04018159
142GABP_19822575_ChIP-Seq_HepG2_Human1.04015804
143BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03844554
144SMAD4_21741376_ChIP-Seq_EPCs_Human1.03736017
145E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03641301
146RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02812009
147CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02690235
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01809794
149CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01520353
150FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01290591
151SALL4_22934838_ChIP-ChIP_CD34+_Human0.99831776
152P300_19829295_ChIP-Seq_ESCs_Human0.99709850
153CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99199597
154STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99159372
155RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98848390
156NOTCH1_21737748_ChIP-Seq_TLL_Human0.96794285
157TTF2_22483619_ChIP-Seq_HELA_Human0.96567787
158ER_23166858_ChIP-Seq_MCF-7_Human0.94677454
159PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94271337
160STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93797026
161YY1_21170310_ChIP-Seq_MESCs_Mouse0.93693431
162IGF1R_20145208_ChIP-Seq_DFB_Human0.89551147
163ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89238362
164STAT3_18555785_Chip-Seq_ESCs_Mouse0.89146478
165GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88976704
166FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.87958929
167JUN_21703547_ChIP-Seq_K562_Human0.86593839
168NELFA_20434984_ChIP-Seq_ESCs_Mouse0.85318868
169LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83714771
170CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83475411
171PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82814925
172ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82726299
173NMYC_18555785_Chip-Seq_ESCs_Mouse0.80729237
174BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80015648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002148_abnormal_hypersensitivity_rea3.36933069
2MP0001835_abnormal_antigen_presentation3.34135005
3MP0003724_increased_susceptibility_to2.98876792
4MP0009785_altered_susceptibility_to2.97941202
5MP0002102_abnormal_ear_morphology2.79599580
6MP0003646_muscle_fatigue2.74487184
7MP0001984_abnormal_olfaction2.67161937
8MP0002822_catalepsy2.62017078
9MP0003436_decreased_susceptibility_to2.60460851
10MP0010386_abnormal_urinary_bladder2.38111331
11MP0005000_abnormal_immune_tolerance2.36869133
12MP0005671_abnormal_response_to2.32974039
13MP0006072_abnormal_retinal_apoptosis2.31420083
14MP0006082_CNS_inflammation2.27218759
15MP0002419_abnormal_innate_immunity2.25438406
16MP0004510_myositis2.22877482
17MP0002837_dystrophic_cardiac_calcinosis2.15888308
18MP0008877_abnormal_DNA_methylation2.13470698
19MP0000569_abnormal_digit_pigmentation2.10411208
20MP0005025_abnormal_response_to2.01856086
21MP0005084_abnormal_gallbladder_morpholo1.92868683
22MP0003787_abnormal_imprinting1.91569571
23MP0005253_abnormal_eye_physiology1.89838575
24MP0009745_abnormal_behavioral_response1.86788060
25MP0004885_abnormal_endolymph1.84527821
26MP0005058_abnormal_lysosome_morphology1.83816145
27MP0004142_abnormal_muscle_tone1.82573707
28MP0000343_altered_response_to1.81128040
29MP0003122_maternal_imprinting1.81061582
30MP0001986_abnormal_taste_sensitivity1.80417140
31MP0002452_abnormal_antigen_presenting1.79895972
32MP0004270_analgesia1.75501821
33MP0002272_abnormal_nervous_system1.75217856
34MP0005551_abnormal_eye_electrophysiolog1.74650588
35MP0002638_abnormal_pupillary_reflex1.69925917
36MP0002332_abnormal_exercise_endurance1.67060671
37MP0002723_abnormal_immune_serum1.66630596
38MP0000685_abnormal_immune_system1.65694340
39MP0005387_immune_system_phenotype1.64124458
40MP0001790_abnormal_immune_system1.64124458
41MP0000372_irregular_coat_pigmentation1.62863343
42MP0005171_absent_coat_pigmentation1.62244863
43MP0002876_abnormal_thyroid_physiology1.61965391
44MP0002163_abnormal_gland_morphology1.61941746
45MP0008260_abnormal_autophagy1.59388204
46MP0005423_abnormal_somatic_nervous1.58754932
47MP0008789_abnormal_olfactory_epithelium1.58725190
48MP0001486_abnormal_startle_reflex1.58459651
49MP0009333_abnormal_splenocyte_physiolog1.57196609
50MP0003121_genomic_imprinting1.56656879
51MP0003880_abnormal_central_pattern1.56490809
52MP0001819_abnormal_immune_cell1.56314805
53MP0005367_renal/urinary_system_phenotyp1.54031149
54MP0000516_abnormal_urinary_system1.54031149
55MP0002420_abnormal_adaptive_immunity1.53967255
56MP0003011_delayed_dark_adaptation1.53814075
57MP0001533_abnormal_skeleton_physiology1.51782624
58MP0001800_abnormal_humoral_immune1.49587292
59MP0004215_abnormal_myocardial_fiber1.47766244
60MP0004147_increased_porphyrin_level1.46604673
61MP0002090_abnormal_vision1.43804886
62MP0003136_yellow_coat_color1.43242712
63MP0000778_abnormal_nervous_system1.43014070
64MP0006036_abnormal_mitochondrial_physio1.42732207
65MP0002928_abnormal_bile_duct1.42015649
66MP0003186_abnormal_redox_activity1.40005615
67MP0001905_abnormal_dopamine_level1.39358501
68MP0002734_abnormal_mechanical_nocicepti1.38905638
69MP0002572_abnormal_emotion/affect_behav1.36491860
70MP0002938_white_spotting1.36104436
71MP0000631_abnormal_neuroendocrine_gland1.34400575
72MP0000015_abnormal_ear_pigmentation1.33970302
73MP0005379_endocrine/exocrine_gland_phen1.33765356
74MP0003828_pulmonary_edema1.33509391
75MP0002405_respiratory_system_inflammati1.32657349
76MP0002064_seizures1.32586825
77MP0000749_muscle_degeneration1.32174053
78MP0005310_abnormal_salivary_gland1.29764953
79MP0002751_abnormal_autonomic_nervous1.29281836
80MP0002909_abnormal_adrenal_gland1.28973592
81MP0005394_taste/olfaction_phenotype1.28909704
82MP0005499_abnormal_olfactory_system1.28909704
83MP0003635_abnormal_synaptic_transmissio1.28667226
84MP0001188_hyperpigmentation1.28069033
85MP0005645_abnormal_hypothalamus_physiol1.27397226
86MP0004133_heterotaxia1.26257948
87MP0001853_heart_inflammation1.26253756
88MP0006292_abnormal_olfactory_placode1.25515352
89MP0004484_altered_response_of1.24599358
90MP0009046_muscle_twitch1.23283147
91MP0004043_abnormal_pH_regulation1.21770085
92MP0001970_abnormal_pain_threshold1.21483694
93MP0006035_abnormal_mitochondrial_morpho1.21309498
94MP0009764_decreased_sensitivity_to1.21081041
95MP0002736_abnormal_nociception_after1.20933640
96MP0004782_abnormal_surfactant_physiolog1.20814767
97MP0005464_abnormal_platelet_physiology1.20108295
98MP0002557_abnormal_social/conspecific_i1.19527220
99MP0000427_abnormal_hair_cycle1.19051359
100MP0005248_abnormal_Harderian_gland1.17752979
101MP0002972_abnormal_cardiac_muscle1.17278619
102MP0003195_calcinosis1.15247923
103MP0001529_abnormal_vocalization1.14764145
104MP0001845_abnormal_inflammatory_respons1.14518015
105MP0004924_abnormal_behavior1.13205289
106MP0005386_behavior/neurological_phenoty1.13205289
107MP0003718_maternal_effect1.12561925
108MP0003890_abnormal_embryonic-extraembry1.12557393
109MP0005174_abnormal_tail_pigmentation1.11614550
110MP0001542_abnormal_bone_strength1.11034227
111MP0001485_abnormal_pinna_reflex1.10973958
112MP0002067_abnormal_sensory_capabilities1.06311461
113MP0006054_spinal_hemorrhage1.06259709
114MP0002063_abnormal_learning/memory/cond1.05967137
115MP0002277_abnormal_respiratory_mucosa1.05230245
116MP0002735_abnormal_chemical_nociception1.04121272
117MP0008058_abnormal_DNA_repair1.04097581
118MP0003303_peritoneal_inflammation1.04070647
119MP0002733_abnormal_thermal_nociception1.03305935
120MP0009697_abnormal_copulation1.02518396
121MP0003252_abnormal_bile_duct1.01932164
122MP0003137_abnormal_impulse_conducting1.01105031
123MP0004036_abnormal_muscle_relaxation1.00238565
124MP0000681_abnormal_thyroid_gland1.00090344
125MP0001968_abnormal_touch/_nociception1.00035780
126MP0004084_abnormal_cardiac_muscle0.99339347
127MP0008469_abnormal_protein_level0.99125221
128MP0002998_abnormal_bone_remodeling0.98269118
129MP0004859_abnormal_synaptic_plasticity0.97766946
130MP0002282_abnormal_trachea_morphology0.97320139
131MP0008004_abnormal_stomach_pH0.96626077
132MP0008995_early_reproductive_senescence0.96406903
133MP0005390_skeleton_phenotype0.95916017
134MP0000858_altered_metastatic_potential0.95751114
135MP0003448_altered_tumor_morphology0.95454616
136MP0000716_abnormal_immune_system0.94574364
137MP0002398_abnormal_bone_marrow0.94039595
138MP0002693_abnormal_pancreas_physiology0.93337676
139MP0000049_abnormal_middle_ear0.92689670
140MP0000647_abnormal_sebaceous_gland0.92565950
141MP0002877_abnormal_melanocyte_morpholog0.92109612
142MP0002653_abnormal_ependyma_morphology0.92062063
143MP0008872_abnormal_physiological_respon0.91774194
144MP0003656_abnormal_erythrocyte_physiolo0.91474797
145MP0002254_reproductive_system_inflammat0.91457543
146MP0000026_abnormal_inner_ear0.90785758
147MP0002234_abnormal_pharynx_morphology0.89683839
148MP0002184_abnormal_innervation0.88393329
149MP0001501_abnormal_sleep_pattern0.88083415
150MP0005164_abnormal_response_to0.87226283
151MP0010678_abnormal_skin_adnexa0.86684428
152MP0005075_abnormal_melanosome_morpholog0.86478884
153MP0001544_abnormal_cardiovascular_syste0.85398113
154MP0005385_cardiovascular_system_phenoty0.85398113
155MP0002233_abnormal_nose_morphology0.84352919
156MP0001879_abnormal_lymphatic_vessel0.83760578
157MP0005195_abnormal_posterior_eye0.83022270
158MP0001764_abnormal_homeostasis0.82958287
159MP0009379_abnormal_foot_pigmentation0.82733580
160MP0000013_abnormal_adipose_tissue0.82601175
161MP0002752_abnormal_somatic_nervous0.80452710
162MP0001963_abnormal_hearing_physiology0.80260240
163MP0002933_joint_inflammation0.80105979
164MP0001727_abnormal_embryo_implantation0.79739419
165MP0005646_abnormal_pituitary_gland0.79261004
166MP0002429_abnormal_blood_cell0.78157785
167MP0003941_abnormal_skin_development0.76821585
168MP0005503_abnormal_tendon_morphology0.76532922
169MP0008775_abnormal_heart_ventricle0.75492263
170MP0000751_myopathy0.74917181
171MP0000689_abnormal_spleen_morphology0.74040339
172MP0003183_abnormal_peptide_metabolism0.72949646
173MP0006276_abnormal_autonomic_nervous0.72216812
174MP0002095_abnormal_skin_pigmentation0.70677716

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.34650854
2Recurrent abscess formation (HP:0002722)5.05475857
3Abnormal mitochondria in muscle tissue (HP:0008316)5.01613679
4Mitochondrial inheritance (HP:0001427)4.92556889
5Hepatocellular necrosis (HP:0001404)4.46681435
6Progressive macrocephaly (HP:0004481)4.39355542
7Increased CSF lactate (HP:0002490)4.28110089
8Recurrent bacterial skin infections (HP:0005406)4.25073941
9Eczematoid dermatitis (HP:0000976)3.96028859
10Hepatic necrosis (HP:0002605)3.85945973
11Acute encephalopathy (HP:0006846)3.81101720
12Pancreatic cysts (HP:0001737)3.54919881
13Vacuolated lymphocytes (HP:0001922)3.36819967
14Molar tooth sign on MRI (HP:0002419)3.29872638
15Abnormality of midbrain morphology (HP:0002418)3.29872638
16Esophageal neoplasm (HP:0100751)3.25701784
17Neoplasm of head and neck (HP:0012288)3.25701784
18Abnormality of macrophages (HP:0004311)3.22794703
19Nephronophthisis (HP:0000090)3.22316126
20Abnormality of glycolysis (HP:0004366)3.21756039
21Increased serum pyruvate (HP:0003542)3.21756039
22Pancreatic fibrosis (HP:0100732)3.19530516
23Hypothermia (HP:0002045)3.16330286
24Exercise intolerance (HP:0003546)3.14877106
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.07645011
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.07645011
27Hemiparesis (HP:0001269)3.06485465
28Recurrent gram-negative bacterial infections (HP:0005420)3.04214005
29Gait imbalance (HP:0002141)3.03515251
30Respiratory failure (HP:0002878)2.98292230
313-Methylglutaconic aciduria (HP:0003535)2.96375298
32Congenital primary aphakia (HP:0007707)2.95211586
33Increased hepatocellular lipid droplets (HP:0006565)2.92966031
34Mediastinal lymphadenopathy (HP:0100721)2.87298142
35Methylmalonic acidemia (HP:0002912)2.86783688
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.81763088
37Optic disc pallor (HP:0000543)2.77816964
38Lactic acidosis (HP:0003128)2.74435580
39Abnormality of the renal medulla (HP:0100957)2.73134496
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.69535853
41Abnormality of alanine metabolism (HP:0010916)2.69535853
42Hyperalaninemia (HP:0003348)2.69535853
43Vertebral compression fractures (HP:0002953)2.68189578
44Exertional dyspnea (HP:0002875)2.68022553
45Obstructive lung disease (HP:0006536)2.63831038
46Chronic obstructive pulmonary disease (HP:0006510)2.63831038
47Genital tract atresia (HP:0001827)2.63739856
48Neuroendocrine neoplasm (HP:0100634)2.63658944
49Intestinal atresia (HP:0011100)2.63634089
50Increased serum lactate (HP:0002151)2.62036372
51Lipid accumulation in hepatocytes (HP:0006561)2.58447143
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.56739941
53Abolished electroretinogram (ERG) (HP:0000550)2.55674201
54Hyperventilation (HP:0002883)2.53324703
55Vaginal atresia (HP:0000148)2.49387368
56Myositis (HP:0100614)2.47472165
57Renal Fanconi syndrome (HP:0001994)2.46467873
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43004933
59Increased cerebral lipofuscin (HP:0011813)2.41329561
60Recurrent skin infections (HP:0001581)2.39290459
61Retrobulbar optic neuritis (HP:0100654)2.39282413
62Optic neuritis (HP:0100653)2.39282413
63Abnormality of the renal cortex (HP:0011035)2.35434104
64Increased intramyocellular lipid droplets (HP:0012240)2.27982483
65Type I transferrin isoform profile (HP:0003642)2.26552765
66Type II lissencephaly (HP:0007260)2.24235255
67Respiratory difficulties (HP:0002880)2.23962276
68Pheochromocytoma (HP:0002666)2.23613535
69Methylmalonic aciduria (HP:0012120)2.23461138
70Chronic hepatic failure (HP:0100626)2.21738774
71Orchitis (HP:0100796)2.16233395
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.13036267
73Poor head control (HP:0002421)2.09549501
74Tinnitus (HP:0000360)2.09455592
75Polyphagia (HP:0002591)2.09402939
76Microvesicular hepatic steatosis (HP:0001414)2.09132326
77Abnormality of the labia minora (HP:0012880)2.09110100
78Cerebral edema (HP:0002181)2.04612899
79Abnormal hair whorl (HP:0010721)2.04513373
80Split foot (HP:0001839)2.03798554
81Hyperinsulinemic hypoglycemia (HP:0000825)2.02995996
82Stomatitis (HP:0010280)2.01596436
83Abnormality of vitamin B metabolism (HP:0004340)2.01143688
84Limb dystonia (HP:0002451)2.00895022
85Gingivitis (HP:0000230)1.99354625
86Petechiae (HP:0000967)1.98777021
87Aplasia/Hypoplasia of the tongue (HP:0010295)1.98645831
88Agnosia (HP:0010524)1.98449653
89Oligodactyly (hands) (HP:0001180)1.97705076
90Hypoglycemic coma (HP:0001325)1.97695430
91Irregular epiphyses (HP:0010582)1.96810161
92Postaxial hand polydactyly (HP:0001162)1.96351863
93Hypokinesia (HP:0002375)1.95236601
94Tubular atrophy (HP:0000092)1.94903399
95Congenital, generalized hypertrichosis (HP:0004540)1.94081725
96Polydipsia (HP:0001959)1.93815263
97Abnormal drinking behavior (HP:0030082)1.93815263
98Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.91795279
99Hyperglycinemia (HP:0002154)1.91498598
100Metaphyseal dysplasia (HP:0100255)1.90418042
101Drooling (HP:0002307)1.90321403
102Abnormality of urine glucose concentration (HP:0011016)1.88708291
103Glycosuria (HP:0003076)1.88708291
104Autoimmune thrombocytopenia (HP:0001973)1.88484394
105Increased muscle lipid content (HP:0009058)1.86452574
106Amyotrophic lateral sclerosis (HP:0007354)1.86347853
107Dialeptic seizures (HP:0011146)1.85809292
108Elevated erythrocyte sedimentation rate (HP:0003565)1.85582226
109Large for gestational age (HP:0001520)1.85556145
110Focal motor seizures (HP:0011153)1.84617516
111Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84528718
112Absent speech (HP:0001344)1.84382768
113Basal ganglia calcification (HP:0002135)1.83853999
114Renal cortical cysts (HP:0000803)1.83591708
115Atonic seizures (HP:0010819)1.83273944
116Febrile seizures (HP:0002373)1.83233878
117Poor coordination (HP:0002370)1.83052583
118Aplasia/hypoplasia of the uterus (HP:0008684)1.82935522
119Abnormal biliary tract physiology (HP:0012439)1.82933115
120Bile duct proliferation (HP:0001408)1.82933115
121Recurrent fungal infections (HP:0002841)1.81879636
122Aplasia/Hypoplasia of the tibia (HP:0005772)1.81733537
123Prostate neoplasm (HP:0100787)1.81648331
124Broad-based gait (HP:0002136)1.81038847
125Ketoacidosis (HP:0001993)1.80072594
126Atrophy/Degeneration involving motor neurons (HP:0007373)1.78496305
127Supernumerary spleens (HP:0009799)1.78332684
128True hermaphroditism (HP:0010459)1.77877685
129Recurrent pneumonia (HP:0006532)1.77631715
130Lissencephaly (HP:0001339)1.77609121
131Hypomagnesemia (HP:0002917)1.77304651
132Oculomotor apraxia (HP:0000657)1.77095648
133Short tibia (HP:0005736)1.76928334
134Gaze-evoked nystagmus (HP:0000640)1.76879759
135Agitation (HP:0000713)1.76458254
136Gliosis (HP:0002171)1.76054962
137Mutism (HP:0002300)1.76028492
138Disproportionate short-trunk short stature (HP:0003521)1.75416777
139Optic nerve hypoplasia (HP:0000609)1.74904344
140Hypoplasia of the fovea (HP:0007750)1.74700433
141Aplasia/Hypoplasia of the fovea (HP:0008060)1.74700433
142Male pseudohermaphroditism (HP:0000037)1.74661129
143Increased IgM level (HP:0003496)1.74294066
144Anencephaly (HP:0002323)1.74224091
145Narrow forehead (HP:0000341)1.72318276
146Abnormality of the anterior horn cell (HP:0006802)1.72310549
147Degeneration of anterior horn cells (HP:0002398)1.72310549
148Sclerocornea (HP:0000647)1.72193909
149Leukodystrophy (HP:0002415)1.72004808
150Medial flaring of the eyebrow (HP:0010747)1.71972232
151Abnormality of the vitamin B12 metabolism (HP:0004341)1.71743956
152Generalized tonic-clonic seizures (HP:0002069)1.71691947
153Median cleft lip (HP:0000161)1.71621863
154Progressive cerebellar ataxia (HP:0002073)1.71446317
155CNS demyelination (HP:0007305)1.71278296
156Attenuation of retinal blood vessels (HP:0007843)1.70802106
157Congenital stationary night blindness (HP:0007642)1.70502397
158Furrowed tongue (HP:0000221)1.70116360
159Excessive salivation (HP:0003781)1.69049075
160X-linked dominant inheritance (HP:0001423)1.68961778
161Osteomyelitis (HP:0002754)1.68734287
162Specific learning disability (HP:0001328)1.68591781
163Broad foot (HP:0001769)1.68078918
164Abnormality of the fovea (HP:0000493)1.66840309
165Congenital sensorineural hearing impairment (HP:0008527)1.65177650
166Beaking of vertebral bodies (HP:0004568)1.65085988
167Conjunctival hamartoma (HP:0100780)1.64419646
168Reduced antithrombin III activity (HP:0001976)1.63331655
169Oligomenorrhea (HP:0000876)1.62449954
170Nausea (HP:0002018)1.61259030
171Abnormal glycosylation (HP:0012345)1.59056299
172Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.59056299
173Abnormal protein N-linked glycosylation (HP:0012347)1.59056299
174Abnormal protein glycosylation (HP:0012346)1.59056299
175Birth length less than 3rd percentile (HP:0003561)1.58447564
176Recurrent cutaneous fungal infections (HP:0011370)1.57868033
177Chronic mucocutaneous candidiasis (HP:0002728)1.57868033
178Purpura (HP:0000979)1.57693652
179Nephrogenic diabetes insipidus (HP:0009806)1.57580765

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.79091298
2CASK3.33501652
3WNK33.07215479
4MAP4K23.04464296
5RIPK43.00047376
6TRIM282.94324332
7MAP3K42.67380608
8PBK2.57341257
9MST42.52443974
10PIM22.46491981
11BMPR22.45368500
12MYLK2.14484717
13NME22.12537996
14STK162.11537711
15EIF2AK12.06667582
16EIF2AK32.05528219
17MAP3K141.99982875
18PINK11.96919388
19PLK21.93890811
20MARK11.93618499
21BLK1.90060876
22NME11.89653259
23ERBB31.85630633
24IRAK31.77444502
25IRAK41.76096127
26MAP2K71.67366041
27TXK1.64964828
28TBK11.64951320
29ADRBK21.63525619
30MAPK131.60028822
31EPHA31.56957162
32ARAF1.53004349
33PRPF4B1.51340203
34SRPK11.49043622
35KIT1.48318229
36GRK71.46314133
37CSNK1G21.46173119
38STK241.46137042
39CSNK1G11.43803538
40SIK31.41015145
41MUSK1.29561336
42PAK31.26375266
43CSNK1G31.24860518
44TRPM71.24125676
45EPHA41.23110218
46DYRK21.22825302
47VRK11.19222472
48JAK31.18868798
49GRK11.18757381
50PLK31.15836170
51TEC1.13689863
52FGFR21.13371301
53TNIK1.13059057
54NEK91.10319435
55PNCK1.09502514
56SYK1.09271040
57PLK41.06074194
58CCNB11.05548801
59INSRR1.04463168
60WEE11.04139470
61IKBKB1.03801061
62CDK81.02214391
63ZAK1.00462278
64YES11.00341824
65DAPK20.99945848
66IKBKE0.99010641
67CAMKK20.97756476
68OXSR10.95608699
69PRKCG0.95378319
70MAP2K40.92299983
71DAPK10.91391224
72NLK0.90559186
73LIMK10.89467016
74CDK190.89450413
75TGFBR10.88619478
76BRAF0.85681539
77TYK20.85357529
78ABL20.83661016
79BMPR1B0.83552315
80CSNK1A1L0.82314317
81NTRK30.82236933
82TNK20.79228832
83PDK20.78577264
84LYN0.77146248
85NTRK20.76470754
86DYRK30.75326259
87EIF2AK20.75166352
88MOS0.75129303
89MINK10.74957673
90TESK10.74874796
91OBSCN0.72557373
92MKNK20.72451184
93ZAP700.70870971
94TAOK10.70474868
95PHKG20.70405926
96PHKG10.70405926
97BUB10.70181219
98FER0.65614111
99CDK30.64493158
100TSSK60.64192369
101GRK50.63026940
102TAOK30.62947880
103KSR10.62747079
104TAOK20.62217007
105STK30.60713983
106MAP3K30.60480594
107PRKCE0.60049951
108STK390.59958578
109BCKDK0.58806812
110PRKCD0.58406345
111FES0.58297235
112PKN10.57535639
113AKT30.56235882
114BCR0.56191375
115FLT30.56151550
116MKNK10.52519051
117MAP3K50.51506005
118ADRBK10.51194966
119PDK30.50314970
120PDK40.50314970
121LCK0.50301318
122TIE10.50073027
123NEK10.49585678
124BTK0.47915539
125DYRK1A0.47553437
126PIM10.47442262
127BRSK20.47125739
128DAPK30.46944114
129MAPKAPK30.44789609
130CHUK0.44576067
131CSNK1A10.44360306
132CAMK2A0.44304662
133NUAK10.43372167
134STK38L0.42556162
135RPS6KA40.41522961
136PRKG10.41275133
137ILK0.40885166
138WNK40.40319501
139MAP4K10.39784043
140MAP2K60.39164958
141RAF10.38626022
142UHMK10.38612670
143MAP3K110.38221225
144PIK3CA0.37976871
145PLK10.37746260
146PRKACA0.36236816
147FRK0.34601452
148FGFR10.33727623
149CAMK2D0.32969652
150PRKACB0.32120509
151PTK2B0.31848327
152ACVR1B0.31624756
153SGK20.31270951
154CSNK1D0.30404879
155MARK30.29681328
156RPS6KA50.29184949
157CSNK2A10.28519429
158PRKG20.28474730
159PASK0.27026199
160TLK10.26255012
161CDK50.24883423

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.24082627
2Proteasome_Homo sapiens_hsa030503.32730154
3Parkinsons disease_Homo sapiens_hsa050123.31312836
4Collecting duct acid secretion_Homo sapiens_hsa049663.08991664
5Protein export_Homo sapiens_hsa030602.82721549
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76380128
7Rheumatoid arthritis_Homo sapiens_hsa053232.62115593
8Alzheimers disease_Homo sapiens_hsa050102.51324839
9Huntingtons disease_Homo sapiens_hsa050162.39033581
10Butanoate metabolism_Homo sapiens_hsa006502.31073211
11Propanoate metabolism_Homo sapiens_hsa006402.27859060
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.22675046
13Vibrio cholerae infection_Homo sapiens_hsa051102.20364457
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.17607418
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17142641
16Phagosome_Homo sapiens_hsa041452.05675871
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.96284291
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95230490
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91158926
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82480439
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.77640845
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75500127
23Fatty acid elongation_Homo sapiens_hsa000621.75112134
24Ribosome_Homo sapiens_hsa030101.72494162
25Graft-versus-host disease_Homo sapiens_hsa053321.72083007
26RNA polymerase_Homo sapiens_hsa030201.69836641
27Legionellosis_Homo sapiens_hsa051341.69427608
28Nitrogen metabolism_Homo sapiens_hsa009101.64350455
29Type I diabetes mellitus_Homo sapiens_hsa049401.63735716
30Allograft rejection_Homo sapiens_hsa053301.60871323
31Steroid biosynthesis_Homo sapiens_hsa001001.54432692
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.54418297
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.51365537
34Asthma_Homo sapiens_hsa053101.48233810
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.48032189
36Synaptic vesicle cycle_Homo sapiens_hsa047211.43440309
37Leishmaniasis_Homo sapiens_hsa051401.43291185
38Sulfur metabolism_Homo sapiens_hsa009201.41239547
39Peroxisome_Homo sapiens_hsa041461.37084757
40GABAergic synapse_Homo sapiens_hsa047271.36025245
41Cardiac muscle contraction_Homo sapiens_hsa042601.33559481
42Tuberculosis_Homo sapiens_hsa051521.32534313
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22701410
44Malaria_Homo sapiens_hsa051441.22367792
45Lysosome_Homo sapiens_hsa041421.21576225
46Other glycan degradation_Homo sapiens_hsa005111.20341663
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13194303
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10273528
49Selenocompound metabolism_Homo sapiens_hsa004501.10084800
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.08552847
51Pertussis_Homo sapiens_hsa051331.05107161
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03571685
53Tryptophan metabolism_Homo sapiens_hsa003801.02587999
54Hematopoietic cell lineage_Homo sapiens_hsa046401.02338248
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98546023
56Regulation of autophagy_Homo sapiens_hsa041400.96647324
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95756447
58beta-Alanine metabolism_Homo sapiens_hsa004100.94987026
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94784435
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94364437
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92611698
62Fatty acid metabolism_Homo sapiens_hsa012120.92586770
63Fanconi anemia pathway_Homo sapiens_hsa034600.92453938
64Salmonella infection_Homo sapiens_hsa051320.91309361
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.91127530
66Pyrimidine metabolism_Homo sapiens_hsa002400.90546500
67Autoimmune thyroid disease_Homo sapiens_hsa053200.90236968
68Basal transcription factors_Homo sapiens_hsa030220.89371267
69Osteoclast differentiation_Homo sapiens_hsa043800.89304985
70Dopaminergic synapse_Homo sapiens_hsa047280.88702432
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85940831
72Ether lipid metabolism_Homo sapiens_hsa005650.85009030
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84880855
74Insulin secretion_Homo sapiens_hsa049110.84343440
75Measles_Homo sapiens_hsa051620.83775687
76Glutamatergic synapse_Homo sapiens_hsa047240.82514420
77Vitamin B6 metabolism_Homo sapiens_hsa007500.81149938
78Antigen processing and presentation_Homo sapiens_hsa046120.80738640
79Mineral absorption_Homo sapiens_hsa049780.80584553
80Folate biosynthesis_Homo sapiens_hsa007900.79110564
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77899491
82Caffeine metabolism_Homo sapiens_hsa002320.77542113
83Base excision repair_Homo sapiens_hsa034100.77399939
84Epstein-Barr virus infection_Homo sapiens_hsa051690.76950973
85Sphingolipid metabolism_Homo sapiens_hsa006000.74239930
86Shigellosis_Homo sapiens_hsa051310.73586174
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73412663
88Amphetamine addiction_Homo sapiens_hsa050310.72220726
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71031212
90Cocaine addiction_Homo sapiens_hsa050300.71019216
91Chemical carcinogenesis_Homo sapiens_hsa052040.70850151
92Influenza A_Homo sapiens_hsa051640.69071766
93Herpes simplex infection_Homo sapiens_hsa051680.67388263
94Homologous recombination_Homo sapiens_hsa034400.67217264
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67054864
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66763457
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66463277
98Mismatch repair_Homo sapiens_hsa034300.65971578
99Apoptosis_Homo sapiens_hsa042100.65314309
100Linoleic acid metabolism_Homo sapiens_hsa005910.64657692
101African trypanosomiasis_Homo sapiens_hsa051430.63344307
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62279525
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60735732
104TNF signaling pathway_Homo sapiens_hsa046680.60520280
105Olfactory transduction_Homo sapiens_hsa047400.60002321
106Purine metabolism_Homo sapiens_hsa002300.59186282
107Nucleotide excision repair_Homo sapiens_hsa034200.58500112
108Glutathione metabolism_Homo sapiens_hsa004800.57819229
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57391511
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.57292005
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57184273
112Oocyte meiosis_Homo sapiens_hsa041140.56951393
113Fatty acid degradation_Homo sapiens_hsa000710.55980722
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55958084
115Nicotine addiction_Homo sapiens_hsa050330.54307104
116Viral myocarditis_Homo sapiens_hsa054160.54041603
117Retinol metabolism_Homo sapiens_hsa008300.53282922
118Serotonergic synapse_Homo sapiens_hsa047260.53007420
119Salivary secretion_Homo sapiens_hsa049700.52582535
120Arachidonic acid metabolism_Homo sapiens_hsa005900.50975529
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50953521
122Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50531984
123Chemokine signaling pathway_Homo sapiens_hsa040620.49508320
124Long-term depression_Homo sapiens_hsa047300.48794636
125RNA degradation_Homo sapiens_hsa030180.47441439
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43407297
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42793048
128Toxoplasmosis_Homo sapiens_hsa051450.42438643
129Pyruvate metabolism_Homo sapiens_hsa006200.42193551
130Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41838233
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41157614
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41090534
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40112861
134DNA replication_Homo sapiens_hsa030300.40023699
135Taste transduction_Homo sapiens_hsa047420.38171796
136Primary immunodeficiency_Homo sapiens_hsa053400.38048880
137Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37039180
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.36297338
139RNA transport_Homo sapiens_hsa030130.35771571
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.35117263
141TGF-beta signaling pathway_Homo sapiens_hsa043500.35117262
142Hepatitis B_Homo sapiens_hsa051610.33367219
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32514085
144Morphine addiction_Homo sapiens_hsa050320.32383609
145Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28760807
146ABC transporters_Homo sapiens_hsa020100.28519808
147Galactose metabolism_Homo sapiens_hsa000520.27537218
148HIF-1 signaling pathway_Homo sapiens_hsa040660.26888768
149Glycosaminoglycan degradation_Homo sapiens_hsa005310.25029427
150Dilated cardiomyopathy_Homo sapiens_hsa054140.24524869
151p53 signaling pathway_Homo sapiens_hsa041150.24348624
152Non-homologous end-joining_Homo sapiens_hsa034500.24249774
153Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24073644
154Circadian rhythm_Homo sapiens_hsa047100.21473656
155Phototransduction_Homo sapiens_hsa047440.19692294
156Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19534582
157Spliceosome_Homo sapiens_hsa030400.19074895
158AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.18596167
159Platelet activation_Homo sapiens_hsa046110.17254427
160Metabolic pathways_Homo sapiens_hsa011000.17211078
161Circadian entrainment_Homo sapiens_hsa047130.17207142

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