ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-fucose catabolic process (GO:0042355)	5.31614268
2	fucose catabolic process (GO:0019317)	5.31614268
3	L-fucose metabolic process (GO:0042354)	5.31614268
4	pyrimidine nucleobase catabolic process (GO:0006208)	4.91734748
5	behavioral response to nicotine (GO:0035095)	4.82542261
6	neuron cell-cell adhesion (GO:0007158)	4.48138533
7	regulation of glucokinase activity (GO:0033131)	4.30106686
8	regulation of hexokinase activity (GO:1903299)	4.30106686
9	neural tube formation (GO:0001841)	4.29239411
10	alkaloid metabolic process (GO:0009820)	4.22350402
11	cornea development in camera-type eye (GO:0061303)	4.19648012
12	nucleobase catabolic process (GO:0046113)	4.12882299
13	glycosphingolipid biosynthetic process (GO:0006688)	4.00816119
14	platelet dense granule organization (GO:0060155)	3.96092557
15	DNA integration (GO:0015074)	3.88430182
16	indolalkylamine metabolic process (GO:0006586)	3.73863203
17	indole-containing compound catabolic process (GO:0042436)	3.67254969
18	indolalkylamine catabolic process (GO:0046218)	3.67254969
19	tryptophan catabolic process (GO:0006569)	3.67254969
20	acrosome reaction (GO:0007340)	3.63781925
21	response to pheromone (GO:0019236)	3.60803166
22	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.52575500
23	transepithelial transport (GO:0070633)	3.47793739
24	startle response (GO:0001964)	3.39314057
25	nephron tubule morphogenesis (GO:0072078)	3.31223103
26	nephron epithelium morphogenesis (GO:0072088)	3.31223103
27	synapse assembly (GO:0007416)	3.26849017
28	water-soluble vitamin biosynthetic process (GO:0042364)	3.24510811
29	kynurenine metabolic process (GO:0070189)	3.22166962
30	synaptic transmission, cholinergic (GO:0007271)	3.18583482
31	postsynaptic membrane organization (GO:0001941)	3.13023036
32	amine catabolic process (GO:0009310)	3.12143113
33	cellular biogenic amine catabolic process (GO:0042402)	3.12143113
34	monoubiquitinated protein deubiquitination (GO:0035520)	3.11306595
35	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.10621505
36	protein-cofactor linkage (GO:0018065)	3.10154333
37	regulation of cilium movement (GO:0003352)	3.05113786
38	rRNA catabolic process (GO:0016075)	3.01189159
39	regulation of collateral sprouting (GO:0048670)	2.99311789
40	protein polyglutamylation (GO:0018095)	2.93626701
41	substrate-independent telencephalic tangential migration (GO:0021826)	2.92052718
42	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.92052718
43	vocalization behavior (GO:0071625)	2.91748090
44	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.90825495
45	regulation of male gonad development (GO:2000018)	2.90676708
46	protein localization to cilium (GO:0061512)	2.90082019
47	tryptophan metabolic process (GO:0006568)	2.86035631
48	inner ear receptor stereocilium organization (GO:0060122)	2.85620326
49	ribonucleoprotein complex disassembly (GO:0032988)	2.84215876
50	regulation of transmission of nerve impulse (GO:0051969)	2.82130163
51	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.79350233
52	presynaptic membrane organization (GO:0097090)	2.79141681
53	protein localization to Golgi apparatus (GO:0034067)	2.78295379
54	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.75423784
55	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.72451370
56	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.70917093
57	epithelial cilium movement (GO:0003351)	2.70746318
58	fucosylation (GO:0036065)	2.70212376
59	benzene-containing compound metabolic process (GO:0042537)	2.68742243
60	respiratory chain complex IV assembly (GO:0008535)	2.67674186
61	embryonic epithelial tube formation (GO:0001838)	2.67644356
62	calcium ion-dependent exocytosis (GO:0017156)	2.67465487
63	axoneme assembly (GO:0035082)	2.67100681
64	renal tubule morphogenesis (GO:0061333)	2.66947925
65	regulation of acrosome reaction (GO:0060046)	2.64832102
66	S-adenosylmethionine metabolic process (GO:0046500)	2.64803679
67	reflex (GO:0060004)	2.64600051
68	regulation of telomere maintenance (GO:0032204)	2.64589490
69	DNA deamination (GO:0045006)	2.61656883
70	protein complex biogenesis (GO:0070271)	2.57986248
71	auditory behavior (GO:0031223)	2.56530903
72	regulation of neuron projection regeneration (GO:0070570)	2.54727027
73	regulation of axon regeneration (GO:0048679)	2.54727027
74	organelle disassembly (GO:1903008)	2.53952731
75	sympathetic nervous system development (GO:0048485)	2.53535414
76	base-excision repair, AP site formation (GO:0006285)	2.53529461
77	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.52994808
78	gamma-aminobutyric acid transport (GO:0015812)	2.51459127
79	mannosylation (GO:0097502)	2.50931755
80	neuron recognition (GO:0008038)	2.50749172
81	auditory receptor cell stereocilium organization (GO:0060088)	2.50009544
82	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.49709919
83	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.49709919
84	NADH dehydrogenase complex assembly (GO:0010257)	2.49709919
85	indole-containing compound metabolic process (GO:0042430)	2.48579713
86	serotonin receptor signaling pathway (GO:0007210)	2.48491756
87	cilium morphogenesis (GO:0060271)	2.47600991
88	epithelial tube formation (GO:0072175)	2.46824806
89	cilium organization (GO:0044782)	2.45549684
90	regulation of meiosis I (GO:0060631)	2.44846889
91	establishment of protein localization to Golgi (GO:0072600)	2.43560666
92	cilium assembly (GO:0042384)	2.42538433
93	behavioral response to ethanol (GO:0048149)	2.42451990
94	histone H3-K4 trimethylation (GO:0080182)	2.42207238
95	protein targeting to Golgi (GO:0000042)	2.42184752
96	cytochrome complex assembly (GO:0017004)	2.41708748
97	kidney morphogenesis (GO:0060993)	2.41403044
98	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.41235857
99	regulation of microtubule-based movement (GO:0060632)	2.40793588
100	RNA destabilization (GO:0050779)	2.39709319

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.68165969
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.28467402
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.16262337
4	VDR_22108803_ChIP-Seq_LS180_Human	3.04369318
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.82618028
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.62783222
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.53083240
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.52521315
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.43236437
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.21894655
11	FUS_26573619_Chip-Seq_HEK293_Human	2.20360386
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.16556988
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.06240946
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04069671
15	P300_19829295_ChIP-Seq_ESCs_Human	2.02352448
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00378801
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.85821198
18	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.80543564
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.79667453
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.79106469
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.75995020
22	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.73259971
23	EWS_26573619_Chip-Seq_HEK293_Human	1.72414323
24	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.69327535
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.69037657
26	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.68000749
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.64393935
28	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.62699363
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.58975561
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.58731019
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58731019
32	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.55565760
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.52586478
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.51853537
35	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.51723065
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.50387511
37	TCF4_23295773_ChIP-Seq_U87_Human	1.49647515
38	AR_25329375_ChIP-Seq_VCAP_Human	1.45507646
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44273063
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44273063
41	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.42737212
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42465742
43	REST_21632747_ChIP-Seq_MESCs_Mouse	1.40281559
44	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.39039917
45	STAT3_23295773_ChIP-Seq_U87_Human	1.38106139
46	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.37938040
47	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.34944233
48	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.33682220
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32851672
50	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30270509
51	BCAT_22108803_ChIP-Seq_LS180_Human	1.29885306
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.29085930
53	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.28832441
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26558085
55	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.26416855
56	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25045656
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.22587769
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.22584672
59	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.22467087
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21615315
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20729757
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20225831
63	MYC_18940864_ChIP-ChIP_HL60_Human	1.19984532
64	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19579531
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18733675
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18455510
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18455510
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.18397091
69	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16129484
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.14840050
71	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.13939006
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13773909
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12110346
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11733583
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11733583
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11299644
77	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.10421894
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10194917
79	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.09995746
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09568089
81	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.09084595
82	AR_21572438_ChIP-Seq_LNCaP_Human	1.08943877
83	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08612005
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08361435
85	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.07430957
86	TCF4_22108803_ChIP-Seq_LS180_Human	1.07008550
87	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.06554992
88	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06223403
89	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.05196509
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05086093
91	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.02448452
92	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.01892001
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01696945
94	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01643229
95	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01289548
96	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99872333
97	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.99182010
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99147745
99	ELK1_19687146_ChIP-ChIP_HELA_Human	0.98213946
100	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98188644

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.39739951
2	MP0003880_abnormal_central_pattern	3.18881836
3	MP0003787_abnormal_imprinting	3.18109074
4	MP0006072_abnormal_retinal_apoptosis	3.04177214
5	MP0006292_abnormal_olfactory_placode	2.78956544
6	MP0002102_abnormal_ear_morphology	2.62147779
7	MP0002876_abnormal_thyroid_physiology	2.56898708
8	MP0006276_abnormal_autonomic_nervous	2.53287390
9	MP0010386_abnormal_urinary_bladder	2.49743410
10	MP0004043_abnormal_pH_regulation	2.20372875
11	MP0003195_calcinosis	2.13798351
12	MP0009046_muscle_twitch	2.10986671
13	MP0005551_abnormal_eye_electrophysiolog	2.07604503
14	MP0004147_increased_porphyrin_level	2.05984835
15	MP0000569_abnormal_digit_pigmentation	1.88392847
16	MP0005253_abnormal_eye_physiology	1.83349535
17	MP0009745_abnormal_behavioral_response	1.82265480
18	MP0001968_abnormal_touch/_nociception	1.79789561
19	MP0002736_abnormal_nociception_after	1.79151918
20	MP0001529_abnormal_vocalization	1.75463949
21	MP0002733_abnormal_thermal_nociception	1.68349076
22	MP0000778_abnormal_nervous_system	1.67244524
23	MP0002272_abnormal_nervous_system	1.60812600
24	MP0002735_abnormal_chemical_nociception	1.59702205
25	MP0001970_abnormal_pain_threshold	1.58088812
26	MP0002909_abnormal_adrenal_gland	1.54163362
27	MP0001486_abnormal_startle_reflex	1.49998977
28	MP0008872_abnormal_physiological_respon	1.49629434
29	MP0001188_hyperpigmentation	1.49504798
30	MP0000631_abnormal_neuroendocrine_gland	1.47457489
31	MP0008995_early_reproductive_senescence	1.42693328
32	MP0004133_heterotaxia	1.40998906
33	MP0002638_abnormal_pupillary_reflex	1.40682573
34	MP0005645_abnormal_hypothalamus_physiol	1.40266346
35	MP0005084_abnormal_gallbladder_morpholo	1.40087105
36	MP0005386_behavior/neurological_phenoty	1.40026748
37	MP0004924_abnormal_behavior	1.40026748
38	MP0003635_abnormal_synaptic_transmissio	1.39465412
39	MP0005379_endocrine/exocrine_gland_phen	1.38892469
40	MP0002557_abnormal_social/conspecific_i	1.38252337
41	MP0004885_abnormal_endolymph	1.37844302
42	MP0002063_abnormal_learning/memory/cond	1.37642606
43	MP0002234_abnormal_pharynx_morphology	1.37157864
44	MP0002277_abnormal_respiratory_mucosa	1.36675456
45	MP0004142_abnormal_muscle_tone	1.34702822
46	MP0003718_maternal_effect	1.32807851
47	MP0008875_abnormal_xenobiotic_pharmacok	1.31820111
48	MP0002139_abnormal_hepatobiliary_system	1.30014984
49	MP0004782_abnormal_surfactant_physiolog	1.29349382
50	MP0003121_genomic_imprinting	1.29041239
51	MP0002572_abnormal_emotion/affect_behav	1.27859176
52	MP0002064_seizures	1.27743418
53	MP0002184_abnormal_innervation	1.26872854
54	MP0005423_abnormal_somatic_nervous	1.23013201
55	MP0005410_abnormal_fertilization	1.22454079
56	MP0001502_abnormal_circadian_rhythm	1.21935477
57	MP0001501_abnormal_sleep_pattern	1.20304129
58	MP0002163_abnormal_gland_morphology	1.18400348
59	MP0002138_abnormal_hepatobiliary_system	1.17744037
60	MP0004145_abnormal_muscle_electrophysio	1.14794768
61	MP0003646_muscle_fatigue	1.14128045
62	MP0000383_abnormal_hair_follicle	1.08750525
63	MP0000647_abnormal_sebaceous_gland	1.08384188
64	MP0005499_abnormal_olfactory_system	1.08190783
65	MP0005394_taste/olfaction_phenotype	1.08190783
66	MP0003136_yellow_coat_color	1.07489914
67	MP0003122_maternal_imprinting	1.06725580
68	MP0001986_abnormal_taste_sensitivity	1.06266556
69	MP0002067_abnormal_sensory_capabilities	1.05227242
70	MP0000372_irregular_coat_pigmentation	1.03908929
71	MP0005646_abnormal_pituitary_gland	1.03562447
72	MP0002229_neurodegeneration	1.02527738
73	MP0009780_abnormal_chondrocyte_physiolo	1.01183933
74	MP0002882_abnormal_neuron_morphology	0.99284332
75	MP0002752_abnormal_somatic_nervous	0.98894650
76	MP0002160_abnormal_reproductive_system	0.98516876
77	MP0002928_abnormal_bile_duct	0.98173051
78	MP0001666_abnormal_nutrient_absorption	0.95422457
79	MP0000427_abnormal_hair_cycle	0.94584179
80	MP0002938_white_spotting	0.93455452
81	MP0005174_abnormal_tail_pigmentation	0.93358325
82	MP0003698_abnormal_male_reproductive	0.89855263
83	MP0002751_abnormal_autonomic_nervous	0.89604538
84	MP0001919_abnormal_reproductive_system	0.88096036
85	MP0001485_abnormal_pinna_reflex	0.85839199
86	MP0005389_reproductive_system_phenotype	0.85514765
87	MP0005195_abnormal_posterior_eye	0.85307312
88	MP0001905_abnormal_dopamine_level	0.85267903
89	MP0005085_abnormal_gallbladder_physiolo	0.84657093
90	MP0009764_decreased_sensitivity_to	0.83374235
91	MP0005365_abnormal_bile_salt	0.81891930
92	MP0001324_abnormal_eye_pigmentation	0.77131376
93	MP0002837_dystrophic_cardiac_calcinosis	0.75784004
94	MP0000955_abnormal_spinal_cord	0.75669070
95	MP0003137_abnormal_impulse_conducting	0.75390478
96	MP0002210_abnormal_sex_determination	0.72606424
97	MP0006035_abnormal_mitochondrial_morpho	0.72423748
98	MP0000026_abnormal_inner_ear	0.71491730
99	MP0001293_anophthalmia	0.70958523
100	MP0003937_abnormal_limbs/digits/tail_de	0.70946462

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.20197275
2	Pancreatic cysts (HP:0001737)	4.04042881
3	Hyperventilation (HP:0002883)	3.90950684
4	Abnormality of midbrain morphology (HP:0002418)	3.81125249
5	Molar tooth sign on MRI (HP:0002419)	3.81125249
6	Limb dystonia (HP:0002451)	3.69393561
7	Pancreatic fibrosis (HP:0100732)	3.45424026
8	Type II lissencephaly (HP:0007260)	3.39377477
9	Lissencephaly (HP:0001339)	3.30933304
10	Agitation (HP:0000713)	3.29060512
11	Drooling (HP:0002307)	3.28999371
12	Nephronophthisis (HP:0000090)	3.02773579
13	Excessive salivation (HP:0003781)	3.00533319
14	Keratoconus (HP:0000563)	2.93623110
15	Increased corneal curvature (HP:0100692)	2.93623110
16	Abnormal rod and cone electroretinograms (HP:0008323)	2.86105816
17	Broad-based gait (HP:0002136)	2.79607540
18	Congenital stationary night blindness (HP:0007642)	2.75438476
19	Abnormality of the labia minora (HP:0012880)	2.75184529
20	Chronic hepatic failure (HP:0100626)	2.69190433
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.67945873
22	Hypothermia (HP:0002045)	2.62295164
23	Abnormality of the renal medulla (HP:0100957)	2.61691032
24	Hypsarrhythmia (HP:0002521)	2.59530942
25	Pachygyria (HP:0001302)	2.59323580
26	Genetic anticipation (HP:0003743)	2.53517112
27	EEG with generalized epileptiform discharges (HP:0011198)	2.50764168
28	Abolished electroretinogram (ERG) (HP:0000550)	2.50028329
29	Cystic liver disease (HP:0006706)	2.44636460
30	Decreased circulating renin level (HP:0003351)	2.43670592
31	Epileptiform EEG discharges (HP:0011182)	2.39888407
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.39651440
33	Absent/shortened dynein arms (HP:0200106)	2.39651440
34	Intestinal atresia (HP:0011100)	2.39103962
35	Medial flaring of the eyebrow (HP:0010747)	2.38546494
36	Concave nail (HP:0001598)	2.35909542
37	Progressive inability to walk (HP:0002505)	2.32482877
38	Patellar aplasia (HP:0006443)	2.32301964
39	Supernumerary spleens (HP:0009799)	2.30834684
40	Absent speech (HP:0001344)	2.29544682
41	Aplasia/Hypoplasia of the patella (HP:0006498)	2.28947829
42	Protruding tongue (HP:0010808)	2.22820117
43	Progressive cerebellar ataxia (HP:0002073)	2.21505535
44	Nephrogenic diabetes insipidus (HP:0009806)	2.20798547
45	Attenuation of retinal blood vessels (HP:0007843)	2.19009383
46	Broad alveolar ridges (HP:0000187)	2.18980436
47	Poor eye contact (HP:0000817)	2.15644590
48	Dandy-Walker malformation (HP:0001305)	2.12705216
49	Decreased central vision (HP:0007663)	2.11885522
50	Cerebellar dysplasia (HP:0007033)	2.11718452
51	Gait imbalance (HP:0002141)	2.07917339
52	Sclerocornea (HP:0000647)	2.02843709
53	Scrotal hypoplasia (HP:0000046)	2.01937380
54	Male pseudohermaphroditism (HP:0000037)	2.01163962
55	Abnormality of the renal cortex (HP:0011035)	2.00973614
56	Anencephaly (HP:0002323)	2.00890957
57	Focal motor seizures (HP:0011153)	2.00697927
58	Lipid accumulation in hepatocytes (HP:0006561)	2.00045772
59	Aplasia/hypoplasia of the uterus (HP:0008684)	1.99472232
60	Inability to walk (HP:0002540)	1.97810688
61	Stomach cancer (HP:0012126)	1.97167019
62	Occipital encephalocele (HP:0002085)	1.96892504
63	Abnormality of dental color (HP:0011073)	1.96467625
64	Abnormal respiratory epithelium morphology (HP:0012253)	1.95904092
65	Abnormal respiratory motile cilium morphology (HP:0005938)	1.95904092
66	Failure to thrive in infancy (HP:0001531)	1.94047562
67	Congenital primary aphakia (HP:0007707)	1.93817640
68	Widely spaced teeth (HP:0000687)	1.93742934
69	Retinal dysplasia (HP:0007973)	1.92804795
70	Optic nerve hypoplasia (HP:0000609)	1.88965856
71	Febrile seizures (HP:0002373)	1.88307849
72	Gaze-evoked nystagmus (HP:0000640)	1.87756281
73	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.87536230
74	Epileptic encephalopathy (HP:0200134)	1.87288774
75	Colon cancer (HP:0003003)	1.86878423
76	Muscular hypotonia of the trunk (HP:0008936)	1.86866848
77	Volvulus (HP:0002580)	1.85460534
78	Disproportionate short-trunk short stature (HP:0003521)	1.84811244
79	Abnormal biliary tract physiology (HP:0012439)	1.83026983
80	Bile duct proliferation (HP:0001408)	1.83026983
81	Barrel-shaped chest (HP:0001552)	1.81898923
82	Limb hypertonia (HP:0002509)	1.81690035
83	Polymicrogyria (HP:0002126)	1.80322231
84	Methylmalonic acidemia (HP:0002912)	1.79914899
85	Furrowed tongue (HP:0000221)	1.78789817
86	Metaphyseal dysplasia (HP:0100255)	1.77308976
87	Increased CSF lactate (HP:0002490)	1.76864463
88	Abnormality of the pubic bones (HP:0003172)	1.75946118
89	Acute necrotizing encephalopathy (HP:0006965)	1.73561641
90	Narrow forehead (HP:0000341)	1.73065561
91	Thyroid-stimulating hormone excess (HP:0002925)	1.71816313
92	Tented upper lip vermilion (HP:0010804)	1.70300688
93	Septo-optic dysplasia (HP:0100842)	1.69319593
94	Abnormality of salivation (HP:0100755)	1.69005550
95	Exotropia (HP:0000577)	1.68891047
96	Prolonged QT interval (HP:0001657)	1.68585483
97	3-Methylglutaconic aciduria (HP:0003535)	1.67260250
98	Progressive microcephaly (HP:0000253)	1.67044503
99	Follicular hyperkeratosis (HP:0007502)	1.66553680
100	Impaired social interactions (HP:0000735)	1.66517829

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	3.63567142
2	MARK1	3.26255336
3	WNK3	3.12627675
4	TRIM28	3.00758236
5	TAOK3	2.90997662
6	PINK1	2.88222039
7	LMTK2	2.86565562
8	NTRK3	2.76861159
9	FRK	2.76187584
10	INSRR	2.56726421
11	ZAK	2.37138238
12	MAPK13	2.21425863
13	TAF1	2.08833091
14	ADRBK2	2.04609211
15	TNIK	1.98988090
16	BCR	1.86525567
17	NUAK1	1.72579866
18	MKNK2	1.64532121
19	EPHA4	1.59886619
20	ERBB3	1.57345898
21	BMPR1B	1.56024169
22	GRK1	1.55833871
23	WNK4	1.51284278
24	DYRK2	1.47367643
25	MAP3K4	1.45465086
26	MAP3K12	1.45382486
27	PIK3CA	1.43654061
28	PAK3	1.42234669
29	MAP2K7	1.38547227
30	MAP4K2	1.33627776
31	BRSK2	1.29799087
32	FLT3	1.28963684
33	PNCK	1.23913652
34	CAMKK2	1.20625511
35	CSNK1G2	1.03560330
36	OXSR1	1.02957885
37	PRKCE	0.97948075
38	MAPKAPK5	0.94206173
39	MKNK1	0.86882964
40	CSNK1G3	0.82238970
41	AKT3	0.80135457
42	PHKG1	0.79011005
43	PHKG2	0.79011005
44	PRKCG	0.76903578
45	MAP2K4	0.76811323
46	DYRK1A	0.76452209
47	VRK1	0.74883177
48	ITK	0.73076726
49	STK39	0.70832314
50	PLK2	0.69228249
51	CSNK1G1	0.68624961
52	MAPKAPK3	0.68230866
53	SIK2	0.67654388
54	PIM2	0.67328057
55	STK38L	0.64797608
56	TEC	0.64136492
57	NTRK2	0.63857300
58	RPS6KA4	0.60760170
59	PRKCQ	0.60257953
60	CHUK	0.59073997
61	DAPK2	0.56777683
62	CAMK1G	0.56211665
63	PTK2B	0.56043527
64	PRKAA1	0.55316474
65	IKBKB	0.54981531
66	SGK2	0.54234238
67	CAMK1D	0.51934905
68	CAMK1	0.51910802
69	VRK2	0.51513676
70	PLK3	0.51088284
71	STK16	0.50206301
72	CAMK2A	0.50025771
73	MAP3K5	0.49242045
74	RPS6KA5	0.49138829
75	SGK223	0.47644045
76	SGK494	0.47644045
77	CAMK2D	0.46059064
78	KIT	0.46013271
79	PRKACA	0.45851047
80	TLK1	0.45229005
81	MARK3	0.45183830
82	PDK2	0.44878299
83	ADRBK1	0.43846048
84	CSNK1A1L	0.43573526
85	PRKACB	0.43559860
86	CSNK1E	0.42036394
87	CSNK1A1	0.41784389
88	WEE1	0.40465757
89	GRK5	0.36597837
90	OBSCN	0.34453197
91	PRKCA	0.34408853
92	FGFR2	0.34066658
93	TIE1	0.33387901
94	CDK3	0.33300956
95	BCKDK	0.33290096
96	GRK7	0.32922587
97	PRKG2	0.32715951
98	PKN1	0.31973389
99	CSNK1D	0.31730156
100	CAMK4	0.31549290

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.97544840
2	Protein export_Homo sapiens_hsa03060	2.91307815
3	Butanoate metabolism_Homo sapiens_hsa00650	2.71961374
4	Basal transcription factors_Homo sapiens_hsa03022	2.63007158
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.47314531
6	Phototransduction_Homo sapiens_hsa04744	2.36218703
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.24990859
8	Asthma_Homo sapiens_hsa05310	2.15787082
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.06197648
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.06043511
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.01214366
12	Oxidative phosphorylation_Homo sapiens_hsa00190	1.94286168
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.94123676
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.87439263
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.87188662
16	Regulation of autophagy_Homo sapiens_hsa04140	1.79284553
17	Collecting duct acid secretion_Homo sapiens_hsa04966	1.76322482
18	Type I diabetes mellitus_Homo sapiens_hsa04940	1.70041406
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.67476996
20	GABAergic synapse_Homo sapiens_hsa04727	1.61728809
21	Allograft rejection_Homo sapiens_hsa05330	1.58913469
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.58712855
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.56322563
24	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.55495122
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.53543037
26	Morphine addiction_Homo sapiens_hsa05032	1.49105263
27	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.48883105
28	Sulfur metabolism_Homo sapiens_hsa00920	1.48248383
29	Graft-versus-host disease_Homo sapiens_hsa05332	1.47458655
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.47264403
31	Taste transduction_Homo sapiens_hsa04742	1.45068491
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.43498218
33	Caffeine metabolism_Homo sapiens_hsa00232	1.43169477
34	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.43009535
35	Circadian rhythm_Homo sapiens_hsa04710	1.42941828
36	Parkinsons disease_Homo sapiens_hsa05012	1.31454157
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.30408368
38	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.29858197
39	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.28760843
40	Rheumatoid arthritis_Homo sapiens_hsa05323	1.27886703
41	RNA polymerase_Homo sapiens_hsa03020	1.26123715
42	Circadian entrainment_Homo sapiens_hsa04713	1.19814875
43	Cardiac muscle contraction_Homo sapiens_hsa04260	1.19689516
44	One carbon pool by folate_Homo sapiens_hsa00670	1.19289904
45	Serotonergic synapse_Homo sapiens_hsa04726	1.17507743
46	Propanoate metabolism_Homo sapiens_hsa00640	1.16386099
47	Insulin secretion_Homo sapiens_hsa04911	1.11379661
48	Dopaminergic synapse_Homo sapiens_hsa04728	1.10018658
49	RNA degradation_Homo sapiens_hsa03018	1.01327530
50	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.01286305
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.97941424
52	Olfactory transduction_Homo sapiens_hsa04740	0.96966810
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.95395441
54	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.94845611
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94785400
56	Amphetamine addiction_Homo sapiens_hsa05031	0.94126509
57	Glutamatergic synapse_Homo sapiens_hsa04724	0.92008424
58	Huntingtons disease_Homo sapiens_hsa05016	0.89578109
59	ABC transporters_Homo sapiens_hsa02010	0.81901110
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80236107
61	Cocaine addiction_Homo sapiens_hsa05030	0.76926173
62	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.75931864
63	Vibrio cholerae infection_Homo sapiens_hsa05110	0.74779787
64	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.73948471
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.73470735
66	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.72981123
67	Fanconi anemia pathway_Homo sapiens_hsa03460	0.72012647
68	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.68072369
69	Type II diabetes mellitus_Homo sapiens_hsa04930	0.63170336
70	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.62235616
71	Cholinergic synapse_Homo sapiens_hsa04725	0.60261500
72	Fatty acid metabolism_Homo sapiens_hsa01212	0.59757613
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56381497
74	Alzheimers disease_Homo sapiens_hsa05010	0.53071166
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52951926
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51254566
77	Peroxisome_Homo sapiens_hsa04146	0.51109207
78	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.48135381
79	Tyrosine metabolism_Homo sapiens_hsa00350	0.47781513
80	Metabolic pathways_Homo sapiens_hsa01100	0.47683317
81	Fatty acid elongation_Homo sapiens_hsa00062	0.47056020
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.46961337
83	Retinol metabolism_Homo sapiens_hsa00830	0.46786294
84	Pancreatic secretion_Homo sapiens_hsa04972	0.46617844
85	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.45992595
86	Chemical carcinogenesis_Homo sapiens_hsa05204	0.45812965
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.44700685
88	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.44106029
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43937094
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40795228
91	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.40202528
92	Mineral absorption_Homo sapiens_hsa04978	0.39846238
93	RNA transport_Homo sapiens_hsa03013	0.38973346
94	Sphingolipid metabolism_Homo sapiens_hsa00600	0.36956106
95	Antigen processing and presentation_Homo sapiens_hsa04612	0.36472548
96	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.34799623
97	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.34450611
98	Long-term depression_Homo sapiens_hsa04730	0.32599895
99	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.32502689
100	Salivary secretion_Homo sapiens_hsa04970	0.32241075

LAMTOR3P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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