LAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.11044449
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.11044449
3L-phenylalanine metabolic process (GO:0006558)6.89087211
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.89087211
5aromatic amino acid family catabolic process (GO:0009074)6.09233381
6glyoxylate metabolic process (GO:0046487)5.75542277
7cysteine metabolic process (GO:0006534)5.62869791
8serine family amino acid biosynthetic process (GO:0009070)5.29813792
9cellular response to type I interferon (GO:0071357)5.27347447
10type I interferon signaling pathway (GO:0060337)5.27347447
11response to type I interferon (GO:0034340)5.20136860
12tryptophan catabolic process (GO:0006569)5.19238446
13indole-containing compound catabolic process (GO:0042436)5.19238446
14indolalkylamine catabolic process (GO:0046218)5.19238446
15kynurenine metabolic process (GO:0070189)5.03638640
16bile acid biosynthetic process (GO:0006699)4.99873805
17serine family amino acid metabolic process (GO:0009069)4.95120504
18tryptophan metabolic process (GO:0006568)4.92305036
19serine family amino acid catabolic process (GO:0009071)4.87300898
20glycine metabolic process (GO:0006544)4.84349373
21immunoglobulin mediated immune response (GO:0016064)4.83866469
22sulfur amino acid catabolic process (GO:0000098)4.80235783
23triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.77640856
24L-serine metabolic process (GO:0006563)4.67655829
25lysine metabolic process (GO:0006553)4.66055375
26lysine catabolic process (GO:0006554)4.66055375
27homocysteine metabolic process (GO:0050667)4.55136423
28alpha-linolenic acid metabolic process (GO:0036109)4.53201474
29aromatic amino acid family metabolic process (GO:0009072)4.49842759
30interferon-gamma-mediated signaling pathway (GO:0060333)4.46163736
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.36337914
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.34813958
33aldehyde catabolic process (GO:0046185)4.34062154
34alpha-amino acid catabolic process (GO:1901606)4.30073614
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.29581224
36urea metabolic process (GO:0019627)4.21001859
37urea cycle (GO:0000050)4.21001859
38bile acid metabolic process (GO:0008206)4.20738598
39negative regulation of interleukin-12 production (GO:0032695)4.15017680
40heme transport (GO:0015886)4.13399793
41antigen processing and presentation of endogenous antigen (GO:0019883)4.12588873
42acetyl-CoA metabolic process (GO:0006084)4.12332577
43cellular amino acid catabolic process (GO:0009063)4.09625133
44amino-acid betaine metabolic process (GO:0006577)4.08818584
45regulation of interferon-alpha production (GO:0032647)4.07850571
46ethanol oxidation (GO:0006069)4.06291883
47regulation of dendritic cell antigen processing and presentation (GO:0002604)4.06128694
48B cell mediated immunity (GO:0019724)4.04617742
49high-density lipoprotein particle remodeling (GO:0034375)4.02998647
50aspartate family amino acid catabolic process (GO:0009068)4.01766216
51negative regulation of fibrinolysis (GO:0051918)4.01123564
52nitrogen cycle metabolic process (GO:0071941)4.00483877
53fatty acid elongation (GO:0030497)3.98601548
54drug transmembrane transport (GO:0006855)3.98427117
55response to peptidoglycan (GO:0032494)3.97721319
56tyrosine metabolic process (GO:0006570)3.97003099
57regulation of triglyceride catabolic process (GO:0010896)3.96529434
58protein carboxylation (GO:0018214)3.94608846
59peptidyl-glutamic acid carboxylation (GO:0017187)3.94608846
60positive regulation of type 2 immune response (GO:0002830)3.93215814
61regulation of T-helper 1 cell differentiation (GO:0045625)3.92646603
62positive regulation of interferon-alpha production (GO:0032727)3.91922422
63urate metabolic process (GO:0046415)3.90678422
64regulation of protein activation cascade (GO:2000257)3.89800619
65macrophage activation involved in immune response (GO:0002281)3.89206190
66cellular modified amino acid catabolic process (GO:0042219)3.87764575
67complement activation, alternative pathway (GO:0006957)3.87630104
68regulation of cholesterol esterification (GO:0010872)3.84557407
69glutamate metabolic process (GO:0006536)3.81049479
70short-chain fatty acid metabolic process (GO:0046459)3.76782735
71regulation of fibrinolysis (GO:0051917)3.76346785
72negative regulation of cholesterol transport (GO:0032375)3.76344382
73negative regulation of sterol transport (GO:0032372)3.76344382
74response to nitrosative stress (GO:0051409)3.73484911
75positive regulation of gamma-delta T cell activation (GO:0046645)3.73272257
76positive regulation by symbiont of host defense response (GO:0052509)3.72516016
77modulation by symbiont of host defense response (GO:0052031)3.72516016
78modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.72516016
79modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.72516016
80positive regulation by organism of defense response of other organism involved in symbiotic interact3.72516016
81modulation by symbiont of host immune response (GO:0052553)3.72516016
82cellular glucuronidation (GO:0052695)3.72340053
83lipopolysaccharide-mediated signaling pathway (GO:0031663)3.72150888
84coenzyme catabolic process (GO:0009109)3.71775287
85amine catabolic process (GO:0009310)3.69261751
86cellular biogenic amine catabolic process (GO:0042402)3.69261751
87drug catabolic process (GO:0042737)3.68498061
88regulation of complement activation (GO:0030449)3.66836738
89response to interferon-beta (GO:0035456)3.64942346
90plasma lipoprotein particle clearance (GO:0034381)3.64805932
91indolalkylamine metabolic process (GO:0006586)3.63838472
92myeloid dendritic cell differentiation (GO:0043011)3.62859773
93regulation of antigen processing and presentation (GO:0002577)3.62324304
94response to interferon-alpha (GO:0035455)3.61906626
95cellular response to interferon-gamma (GO:0071346)3.61599574
96negative regulation of viral genome replication (GO:0045071)3.61337149
97positive regulation of antigen processing and presentation (GO:0002579)3.61178508
98T-helper 1 type immune response (GO:0042088)3.59599177
99organic acid catabolic process (GO:0016054)3.58825406
100carboxylic acid catabolic process (GO:0046395)3.58825406
101cellular ketone body metabolic process (GO:0046950)3.56361911
102very long-chain fatty acid metabolic process (GO:0000038)3.55782243
103branched-chain amino acid catabolic process (GO:0009083)3.53053693
104plasma lipoprotein particle remodeling (GO:0034369)3.50217354
105protein-lipid complex remodeling (GO:0034368)3.50217354
106macromolecular complex remodeling (GO:0034367)3.50217354
107reverse cholesterol transport (GO:0043691)3.50103897
108detection of molecule of bacterial origin (GO:0032490)3.49348184
109acylglycerol homeostasis (GO:0055090)3.47850147
110triglyceride homeostasis (GO:0070328)3.47850147
111glucuronate metabolic process (GO:0019585)3.47603340
112uronic acid metabolic process (GO:0006063)3.47603340
113benzene-containing compound metabolic process (GO:0042537)3.46244830
114regulation of vitamin D biosynthetic process (GO:0060556)3.45789844
115imidazole-containing compound metabolic process (GO:0052803)3.45165229
116regulation of type I interferon-mediated signaling pathway (GO:0060338)3.44386269
117detection of other organism (GO:0098543)3.44218186
118response to interferon-gamma (GO:0034341)3.43946028
119fatty acid beta-oxidation (GO:0006635)3.42615139
120cholesterol homeostasis (GO:0042632)3.41633181
121positive regulation of lipoprotein lipase activity (GO:0051006)3.39696310
122positive regulation of triglyceride lipase activity (GO:0061365)3.39696310
123drug transport (GO:0015893)3.38357872
124sterol homeostasis (GO:0055092)3.37596970
125cholesterol biosynthetic process (GO:0006695)3.36541599
126NIK/NF-kappaB signaling (GO:0038061)3.35941852
127cellular response to interferon-alpha (GO:0035457)3.34180167
128myeloid dendritic cell activation (GO:0001773)3.33480281
129regulation of bile acid biosynthetic process (GO:0070857)3.32010630
130regulation of interferon-beta biosynthetic process (GO:0045357)3.31751055
131bile acid and bile salt transport (GO:0015721)3.31053067
132fatty acid oxidation (GO:0019395)3.30858517
133very-low-density lipoprotein particle assembly (GO:0034379)3.30704265
134drug metabolic process (GO:0017144)3.30697873
135T cell migration (GO:0072678)3.30203314
136cofactor catabolic process (GO:0051187)3.30027167
137detection of bacterium (GO:0016045)3.29640570
138branched-chain amino acid metabolic process (GO:0009081)3.25976091
139cholesterol efflux (GO:0033344)3.25968978
140lipid oxidation (GO:0034440)3.25614196
141exogenous drug catabolic process (GO:0042738)3.25593155
142regulation of mononuclear cell migration (GO:0071675)3.25231507
143detection of external biotic stimulus (GO:0098581)3.24759782
144regulation of cholesterol metabolic process (GO:0090181)3.24759082
145thioester metabolic process (GO:0035383)3.24753312
146acyl-CoA metabolic process (GO:0006637)3.24753312
147regulation of T cell tolerance induction (GO:0002664)3.18672717
148neutrophil activation involved in immune response (GO:0002283)3.17747380
149antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.16930145
150positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.16472098
151cellular response to interferon-beta (GO:0035458)3.09051757
152regulation of vitamin metabolic process (GO:0030656)3.08438062
153positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.06267504
154positive regulation of toll-like receptor signaling pathway (GO:0034123)3.05482718
155lymphocyte chemotaxis (GO:0048247)3.03957574
156regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.03872324
157dendritic cell differentiation (GO:0097028)3.00791104
158defense response to protozoan (GO:0042832)3.00495967
159regulation of type 2 immune response (GO:0002828)2.99584911
160regulation of cytokine secretion involved in immune response (GO:0002739)2.99145018
161positive regulation of interferon-beta production (GO:0032728)2.95568306
162defense response to virus (GO:0051607)2.94265482
163negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93020106
164negative regulation of cell killing (GO:0031342)2.93020106
165regulation of hypersensitivity (GO:0002883)2.92079790
166regulation of interleukin-12 production (GO:0032655)2.91633078
167regulation of podosome assembly (GO:0071801)2.88479446
168response to protozoan (GO:0001562)2.88163427
169regulation of RIG-I signaling pathway (GO:0039535)2.87894619
170regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.87865669
171regulation of tolerance induction (GO:0002643)2.87269069
172regulation of response to interferon-gamma (GO:0060330)2.87218888
173germinal center formation (GO:0002467)2.87177536
174negative regulation of cytokine production involved in immune response (GO:0002719)2.85551901
175regulation of macrophage chemotaxis (GO:0010758)2.83269735
176detection of biotic stimulus (GO:0009595)2.81737786
177response to host immune response (GO:0052572)2.79030365
178response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.79030365
179negative regulation of myeloid cell apoptotic process (GO:0033033)2.77880883
180positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.76336513
181regulation of chronic inflammatory response (GO:0002676)2.74675764
182positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.73249275
183glycosphingolipid catabolic process (GO:0046479)2.72598629
184cellular response to exogenous dsRNA (GO:0071360)2.68288766
185regulation of inflammatory response to antigenic stimulus (GO:0002861)2.68168475
186cellular response to thyroid hormone stimulus (GO:0097067)2.67730056
187production of molecular mediator involved in inflammatory response (GO:0002532)2.66027682
188regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.65166745
189pinocytosis (GO:0006907)2.64655828
190negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.63549567
191positive regulation of interleukin-12 production (GO:0032735)2.63330960
192positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.60439629
193eosinophil chemotaxis (GO:0048245)2.59049043
194myeloid cell activation involved in immune response (GO:0002275)2.58790946
195negative regulation of innate immune response (GO:0045824)2.56981925
196regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.56017238
197positive regulation of chemokine biosynthetic process (GO:0045080)2.55822730
198cellular response to lipopolysaccharide (GO:0071222)2.55194343
199response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.51728323
200response to host defenses (GO:0052200)2.51728323

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.81855013
2IRF8_22096565_ChIP-ChIP_GC-B_Human7.26186674
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.96034993
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.28614029
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.12537416
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.00212596
7BP1_19119308_ChIP-ChIP_Hs578T_Human4.69719318
8IRF8_21731497_ChIP-ChIP_J774_Mouse4.67101540
9LXR_22158963_ChIP-Seq_LIVER_Mouse4.58811938
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.06507019
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.98201882
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.84248144
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.49544456
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.34693146
15IRF8_27001747_Chip-Seq_BMDM_Mouse3.23005637
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.17170163
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.00892889
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85858073
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83930436
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.82025227
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77687452
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59473373
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.53271079
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50447665
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44775277
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.44394384
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.37298037
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27632611
29GATA1_22025678_ChIP-Seq_K562_Human2.21766842
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.17815102
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.16454596
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.10825175
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.04953908
34SPI1_23547873_ChIP-Seq_NB4_Human2.04145385
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92678076
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86616687
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.83811174
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82089454
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80532000
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.80467943
41AR_21909140_ChIP-Seq_LNCAP_Human1.80445425
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.80067794
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.80067794
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.80067794
45VDR_24763502_ChIP-Seq_THP-1_Human1.77868152
46* MYC_18555785_ChIP-Seq_MESCs_Mouse1.77618328
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76415323
48MYB_26560356_Chip-Seq_TH2_Human1.70968957
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69563780
50VDR_21846776_ChIP-Seq_THP-1_Human1.67790325
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61729383
52* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.61239357
53MAF_26560356_Chip-Seq_TH1_Human1.60913618
54SPI1_23127762_ChIP-Seq_K562_Human1.59830677
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57996794
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52678478
57CLOCK_20551151_ChIP-Seq_293T_Human1.51676076
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50997758
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50146616
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49473462
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48523841
62VDR_24787735_ChIP-Seq_THP-1_Human1.48443081
63NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.48355676
64MYB_26560356_Chip-Seq_TH1_Human1.47294454
65TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.43842990
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43508199
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.43329713
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40173069
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40068346
70* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39541651
71* RUNX1_22412390_ChIP-Seq_EML_Mouse1.37524770
72JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34702124
73MYC_22102868_ChIP-Seq_BL_Human1.34423501
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33340653
75SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32960752
76* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.32949366
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32763630
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29883370
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29294398
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28265272
81SCL_19346495_ChIP-Seq_HPC-7_Human1.25635425
82* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25302072
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24190308
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24139599
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23746617
86TFEB_21752829_ChIP-Seq_HELA_Human1.23547013
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22684279
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22578443
89RUNX_20019798_ChIP-Seq_JUKART_Human1.20889314
90GABP_17652178_ChIP-ChIP_JURKAT_Human1.20685807
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19655074
92* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16300581
93* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.15562594
94PU_27001747_Chip-Seq_BMDM_Mouse1.15123912
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14920489
96MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14562360
97SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13517396
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13367583
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12889011
100ELK3_25401928_ChIP-Seq_HUVEC_Human1.12808802
101EST1_17652178_ChIP-ChIP_JURKAT_Human1.12305379
102SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12025318
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11554784
104UTX_26944678_Chip-Seq_JUKART_Human1.11530350
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11212238
106HNF4A_19822575_ChIP-Seq_HepG2_Human1.10603594
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09445221
108NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09333568
109CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08930839
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08799955
111ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08042816
112* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07827867
113* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06798463
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06772770
115ETS1_20019798_ChIP-Seq_JURKAT_Human1.06397255
116GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06236994
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04799431
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04640703
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04524618
120LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04217659
121CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04008407
122GATA4_25053715_ChIP-Seq_YYC3_Human1.03315143
123NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02232037
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02175536
125GATA2_21666600_ChIP-Seq_HMVEC_Human1.01927240
126ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01262105
127SOX17_20123909_ChIP-Seq_XEN_Mouse1.01105859
128* MAF_26560356_Chip-Seq_TH2_Human0.98710112
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98019611
130GATA3_27048872_Chip-Seq_THYMUS_Human0.97763643
131RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97591874
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96949851
133FOXA2_19822575_ChIP-Seq_HepG2_Human0.96596352
134GATA3_26560356_Chip-Seq_TH2_Human0.95706731
135SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95264512
136* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94453615
137PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92926073
138HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92578507
139POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92175610
140* SRF_21415370_ChIP-Seq_HL-1_Mouse0.91498275
141ZNF263_19887448_ChIP-Seq_K562_Human0.91460264
142LXR_22292898_ChIP-Seq_THP-1_Human0.90927618
143SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90208813
144E2F7_22180533_ChIP-Seq_HELA_Human0.89999525
145STAT1_20625510_ChIP-Seq_HELA_Human0.87124159
146HTT_18923047_ChIP-ChIP_STHdh_Human0.86908366
147GATA1_19941827_ChIP-Seq_MEL_Mouse0.86286410
148GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86283242
149PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86109781
150KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85724367
151FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85004777
152THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84069775
153TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82144369
154POU5F1_16518401_ChIP-PET_MESCs_Mouse0.81617616
155EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.80939251
156* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.80740915
157TCF7_22412390_ChIP-Seq_EML_Mouse0.80723127
158SOX2_20726797_ChIP-Seq_SW620_Human0.79448456
159NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79427189
160ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78733710
161IRF1_19129219_ChIP-ChIP_H3396_Human0.78194326
162XRN2_22483619_ChIP-Seq_HELA_Human0.76548142
163* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.76115858
164* DCP1A_22483619_ChIP-Seq_HELA_Human0.75987141
165MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.75434342
166TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74678136
167* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.74609289
168* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.73565151
169GATA6_25053715_ChIP-Seq_YYC3_Human0.72625659
170ESR2_21235772_ChIP-Seq_MCF-7_Human0.72344847
171KLF4_18555785_ChIP-Seq_MESCs_Mouse0.72073459
172ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71912108
173RARG_19884340_ChIP-ChIP_MEFs_Mouse0.71319360
174KAP1_22055183_ChIP-Seq_ESCs_Mouse0.69997248
175FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67508026
176CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.67399373
177TP63_17297297_ChIP-ChIP_HaCaT_Human0.64696642
178FOXO3_23340844_ChIP-Seq_DLD1_Human0.64604608
179SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.63546912
180ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.62405638

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.29428744
2MP0002139_abnormal_hepatobiliary_system7.03848262
3MP0003806_abnormal_nucleotide_metabolis6.13380752
4MP0005085_abnormal_gallbladder_physiolo5.21027196
5MP0005365_abnormal_bile_salt4.75681605
6MP0008875_abnormal_xenobiotic_pharmacok4.30481646
7MP0003303_peritoneal_inflammation4.05743534
8MP0001835_abnormal_antigen_presentation4.05252523
9MP0009840_abnormal_foam_cell3.39341610
10MP0003724_increased_susceptibility_to3.34835032
11MP0009785_altered_susceptibility_to3.34080814
12MP0005332_abnormal_amino_acid3.18647889
13MP0002148_abnormal_hypersensitivity_rea3.07068616
14MP0003252_abnormal_bile_duct2.97887656
15MP0003436_decreased_susceptibility_to2.88084161
16MP0003195_calcinosis2.84531873
17MP0005387_immune_system_phenotype2.83362306
18MP0001790_abnormal_immune_system2.83362306
19MP0005671_abnormal_response_to2.69500204
20MP0005000_abnormal_immune_tolerance2.68339795
21MP0010329_abnormal_lipoprotein_level2.61357752
22MP0005025_abnormal_response_to2.61086694
23MP0001666_abnormal_nutrient_absorption2.59996589
24MP0000685_abnormal_immune_system2.57168986
25MP0002419_abnormal_innate_immunity2.44098532
26MP0001800_abnormal_humoral_immune2.43212336
27MP0003300_gastrointestinal_ulcer2.34891886
28MP0004019_abnormal_vitamin_homeostasis2.31458967
29MP0002452_abnormal_antigen_presenting2.29756693
30MP0002723_abnormal_immune_serum2.20226654
31MP0005083_abnormal_biliary_tract2.16719755
32MP0003186_abnormal_redox_activity2.10730218
33MP0010155_abnormal_intestine_physiology1.94922770
34MP0003191_abnormal_cellular_cholesterol1.91131029
35MP0001819_abnormal_immune_cell1.88484234
36MP0000343_altered_response_to1.87636123
37MP0005451_abnormal_body_composition1.87482956
38MP0002420_abnormal_adaptive_immunity1.87447024
39MP0001845_abnormal_inflammatory_respons1.84462382
40MP0002118_abnormal_lipid_homeostasis1.77728296
41MP0001853_heart_inflammation1.77674277
42MP0003075_altered_response_to1.77188464
43MP0001533_abnormal_skeleton_physiology1.75100670
44MP0004947_skin_inflammation1.73169046
45MP0004510_myositis1.71592492
46MP0000609_abnormal_liver_physiology1.68683827
47MP0009643_abnormal_urine_homeostasis1.64967490
48MP0009333_abnormal_splenocyte_physiolog1.60396112
49MP0005319_abnormal_enzyme/_coenzyme1.59784819
50MP0005166_decreased_susceptibility_to1.56875451
51MP0001764_abnormal_homeostasis1.51843027
52MP0005464_abnormal_platelet_physiology1.51512808
53MP0003448_altered_tumor_morphology1.47417826
54MP0005584_abnormal_enzyme/coenzyme_acti1.45968891
55MP0002405_respiratory_system_inflammati1.43226231
56MP0003172_abnormal_lysosome_physiology1.41449633
57MP0000716_abnormal_immune_system1.41295622
58MP0004043_abnormal_pH_regulation1.41016600
59MP0003705_abnormal_hypodermis_morpholog1.40094801
60MP0000858_altered_metastatic_potential1.39628187
61MP0002138_abnormal_hepatobiliary_system1.37076391
62MP0005310_abnormal_salivary_gland1.37025738
63MP0002166_altered_tumor_susceptibility1.31744695
64MP0002998_abnormal_bone_remodeling1.30354528
65MP0002398_abnormal_bone_marrow1.29963369
66MP0003690_abnormal_glial_cell1.28570375
67MP0008004_abnormal_stomach_pH1.28099396
68MP0003718_maternal_effect1.23306115
69MP0005397_hematopoietic_system_phenotyp1.22969459
70MP0001545_abnormal_hematopoietic_system1.22969459
71MP0002877_abnormal_melanocyte_morpholog1.19612401
72MP0003763_abnormal_thymus_physiology1.19560386
73MP0000920_abnormal_myelination1.18524560
74MP0003868_abnormal_feces_composition1.17455889
75MP0005408_hypopigmentation1.17441813
76MP0008260_abnormal_autophagy1.16297639
77MP0003011_delayed_dark_adaptation1.15701226
78MP0002429_abnormal_blood_cell1.15629707
79MP0006036_abnormal_mitochondrial_physio1.14318876
80MP0009278_abnormal_bone_marrow1.14124133
81MP0003950_abnormal_plasma_membrane1.11779885
82MP0000689_abnormal_spleen_morphology1.09693751
83MP0005167_abnormal_blood-brain_barrier1.09187738
84MP0001661_extended_life_span1.08293016
85MP0002796_impaired_skin_barrier1.07422588
86MP0005164_abnormal_response_to1.05406768
87MP0000598_abnormal_liver_morphology1.05325539
88MP0002722_abnormal_immune_system1.04253454
89MP0002006_tumorigenesis1.02813582
90MP0009697_abnormal_copulation1.02589470
91MP0005636_abnormal_mineral_homeostasis1.01161439
92MP0006054_spinal_hemorrhage0.98240780
93MP0005266_abnormal_metabolism0.97389530
94MP0003091_abnormal_cell_migration0.95831946
95MP0003656_abnormal_erythrocyte_physiolo0.95658891
96MP0005165_increased_susceptibility_to0.95341565
97MP0000604_amyloidosis0.91486913
98MP0003828_pulmonary_edema0.90442329
99MP0005058_abnormal_lysosome_morphology0.89854202
100MP0004883_abnormal_blood_vessel0.89421240
101MP0002332_abnormal_exercise_endurance0.87827641
102MP0005647_abnormal_sex_gland0.87645103
103MP0000465_gastrointestinal_hemorrhage0.86996104
104MP0003183_abnormal_peptide_metabolism0.86637726
105MP0009053_abnormal_anal_canal0.86427345
106MP0005376_homeostasis/metabolism_phenot0.85291855
107MP0009765_abnormal_xenobiotic_induced0.84336274
108MP0003329_amyloid_beta_deposits0.84076960
109MP0001756_abnormal_urination0.81888235
110MP0009763_increased_sensitivity_to0.79299906
111MP0003866_abnormal_defecation0.77927979
112MP0000249_abnormal_blood_vessel0.77903877
113MP0005395_other_phenotype0.76836493
114MP0002254_reproductive_system_inflammat0.75777588
115MP0002136_abnormal_kidney_physiology0.73426960
116MP0004808_abnormal_hematopoietic_stem0.73222756
117MP0005666_abnormal_adipose_tissue0.72364677
118MP0004147_increased_porphyrin_level0.71729153
119MP0001873_stomach_inflammation0.69416659
120MP0004264_abnormal_extraembryonic_tissu0.68855005
121MP0010234_abnormal_vibrissa_follicle0.68805536
122MP0004885_abnormal_endolymph0.68542963
123MP0010678_abnormal_skin_adnexa0.68152425
124MP0005501_abnormal_skin_physiology0.66707335
125MP0000579_abnormal_nail_morphology0.66452469
126MP0009764_decreased_sensitivity_to0.66415530
127MP0000462_abnormal_digestive_system0.65804089
128MP0001663_abnormal_digestive_system0.65415114
129MP0004133_heterotaxia0.65120076
130MP0005390_skeleton_phenotype0.64554115
131MP0004185_abnormal_adipocyte_glucose0.64521578
132MP0002098_abnormal_vibrissa_morphology0.64163463
133MP0006035_abnormal_mitochondrial_morpho0.63558378
134MP0008874_decreased_physiological_sensi0.63373217
135MP0003795_abnormal_bone_structure0.62428379
136MP0000647_abnormal_sebaceous_gland0.62306748
137MP0003453_abnormal_keratinocyte_physiol0.62247121
138MP0000467_abnormal_esophagus_morphology0.62063667
139MP0000490_abnormal_crypts_of0.61573973
140MP0008469_abnormal_protein_level0.60862809
141MP0009642_abnormal_blood_homeostasis0.60588613
142MP0005670_abnormal_white_adipose0.59981182
143MP0004957_abnormal_blastocyst_morpholog0.59699974
144MP0000377_abnormal_hair_follicle0.59282450
145MP0010307_abnormal_tumor_latency0.59037078
146MP0001730_embryonic_growth_arrest0.57757837
147MP0008438_abnormal_cutaneous_collagen0.56682239
148MP0008873_increased_physiological_sensi0.54653761
149MP0003136_yellow_coat_color0.54261808
150MP0005084_abnormal_gallbladder_morpholo0.53115259
151MP0004381_abnormal_hair_follicle0.52683179
152MP0000566_synostosis0.52677318
153MP0005220_abnormal_exocrine_pancreas0.51752164
154MP0001243_abnormal_dermal_layer0.51006679
155MP0003632_abnormal_nervous_system0.50424460
156MP0000537_abnormal_urethra_morphology0.47992855
157MP0005023_abnormal_wound_healing0.47263528
158MP0002971_abnormal_brown_adipose0.46161910
159MP0009672_abnormal_birth_weight0.42699337
160MP0002295_abnormal_pulmonary_circulatio0.41416678
161MP0000383_abnormal_hair_follicle0.41227205
162MP0006082_CNS_inflammation0.40241873
163MP0001293_anophthalmia0.38471737
164MP0009384_cardiac_valve_regurgitation0.37933654
165MP0000747_muscle_weakness0.37782032
166MP0003221_abnormal_cardiomyocyte_apopto0.37101288
167MP0001485_abnormal_pinna_reflex0.36553526
168MP0002269_muscular_atrophy0.36041857
169MP0010352_gastrointestinal_tract_polyps0.35737403
170MP0002111_abnormal_tail_morphology0.34734130

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.62021666
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.37639455
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.69047459
4Hypobetalipoproteinemia (HP:0003563)5.45765090
5Xanthomatosis (HP:0000991)5.23494514
6Deep venous thrombosis (HP:0002625)5.03465638
7Abnormality of serine family amino acid metabolism (HP:0010894)4.87154564
8Abnormality of glycine metabolism (HP:0010895)4.87154564
9Hyperglycinuria (HP:0003108)4.78278772
10Abnormality of glycolipid metabolism (HP:0010969)4.68710353
11Abnormality of liposaccharide metabolism (HP:0010968)4.68710353
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.68710353
13Hyperglycinemia (HP:0002154)4.61642404
14Recurrent bacterial skin infections (HP:0005406)4.48163133
15Hyperammonemia (HP:0001987)4.44906162
16Abnormality of aspartate family amino acid metabolism (HP:0010899)4.31617938
17Prolonged partial thromboplastin time (HP:0003645)4.27207111
18Abnormality of macrophages (HP:0004311)4.25811982
19Eczematoid dermatitis (HP:0000976)4.25683625
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.21810116
21Recurrent abscess formation (HP:0002722)4.20471200
22Abnormality of sulfur amino acid metabolism (HP:0004339)4.18101698
23Hyperlipoproteinemia (HP:0010980)4.09866673
24Abnormality of methionine metabolism (HP:0010901)4.02668732
25Glomerulonephritis (HP:0000099)3.92605575
26Fat malabsorption (HP:0002630)3.86682847
27Orchitis (HP:0100796)3.84685567
28Hypolipoproteinemia (HP:0010981)3.83531117
29Optic neuritis (HP:0100653)3.77772248
30Retrobulbar optic neuritis (HP:0100654)3.77772248
31Complement deficiency (HP:0004431)3.77307140
32Ketosis (HP:0001946)3.71522646
33Recurrent gram-negative bacterial infections (HP:0005420)3.59624288
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.57893389
35Abnormality of pyrimidine metabolism (HP:0004353)3.52428489
36Myositis (HP:0100614)3.52107566
37Epidermoid cyst (HP:0200040)3.49221395
38Abnormality of fatty-acid metabolism (HP:0004359)3.45911855
39Mediastinal lymphadenopathy (HP:0100721)3.41969037
40Hypoglycemic coma (HP:0001325)3.34424706
41Abnormality of serum amino acid levels (HP:0003112)3.24405077
42Recurrent viral infections (HP:0004429)3.23613870
43Delayed CNS myelination (HP:0002188)3.20866051
44Vacuolated lymphocytes (HP:0001922)3.15184203
45Vasculitis (HP:0002633)3.14678952
46Steatorrhea (HP:0002570)3.11186738
47Recurrent skin infections (HP:0001581)3.05687087
48Loss of speech (HP:0002371)3.04780164
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.02269464
50Increased serum pyruvate (HP:0003542)2.97606161
51Abnormality of glycolysis (HP:0004366)2.97606161
52Abnormality of nucleobase metabolism (HP:0010932)2.96834273
53Lethargy (HP:0001254)2.94140225
54Hypoalphalipoproteinemia (HP:0003233)2.93351494
55Colitis (HP:0002583)2.92195053
56Dicarboxylic aciduria (HP:0003215)2.91333235
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.91333235
58Pulmonary infiltrates (HP:0002113)2.88402285
59Increased IgM level (HP:0003496)2.87444607
60Recurrent fungal infections (HP:0002841)2.82999799
61Meningitis (HP:0001287)2.82152363
62Abnormality of the common coagulation pathway (HP:0010990)2.80477370
63Gout (HP:0001997)2.80201981
64Spastic diplegia (HP:0001264)2.79471089
65Dysostosis multiplex (HP:0000943)2.77312722
66Recurrent cutaneous fungal infections (HP:0011370)2.75949181
67Chronic mucocutaneous candidiasis (HP:0002728)2.75949181
68Malnutrition (HP:0004395)2.74406037
69Joint hemorrhage (HP:0005261)2.74402672
70Abnormality of complement system (HP:0005339)2.71747146
71Vascular calcification (HP:0004934)2.70007921
72Recurrent bronchitis (HP:0002837)2.69127992
73Abnormality of purine metabolism (HP:0004352)2.69037165
74Conjugated hyperbilirubinemia (HP:0002908)2.68443922
75Ketoacidosis (HP:0001993)2.68251982
76Disinhibition (HP:0000734)2.68103356
77Keratoconjunctivitis sicca (HP:0001097)2.67146265
78Autoimmune thrombocytopenia (HP:0001973)2.66813797
79Gastrointestinal stroma tumor (HP:0100723)2.66498582
80Purpura (HP:0000979)2.63716110
81Chronic otitis media (HP:0000389)2.63626145
82Metabolic acidosis (HP:0001942)2.63029342
83Increased cerebral lipofuscin (HP:0011813)2.62626441
84Cerebral edema (HP:0002181)2.62336914
85Hemoptysis (HP:0002105)2.61862826
86Proximal tubulopathy (HP:0000114)2.59772414
87Chronic obstructive pulmonary disease (HP:0006510)2.57480613
88Obstructive lung disease (HP:0006536)2.57480613
89Gastrointestinal infarctions (HP:0005244)2.56908131
90Abnormality of the intrinsic pathway (HP:0010989)2.55586071
91Spastic paraparesis (HP:0002313)2.54667568
92Gingivitis (HP:0000230)2.52455359
93Hypercholesterolemia (HP:0003124)2.49327956
94Hyperbilirubinemia (HP:0002904)2.49090328
95Elevated erythrocyte sedimentation rate (HP:0003565)2.48463922
96IgA deficiency (HP:0002720)2.47081160
97Generalized aminoaciduria (HP:0002909)2.46518056
98Irritability (HP:0000737)2.45223245
99Rickets (HP:0002748)2.44160123
100Abnormality of the nasal mucosa (HP:0000433)2.41119845
101Nephritis (HP:0000123)2.39124488
102Autoimmune hemolytic anemia (HP:0001890)2.38725453
103Urticaria (HP:0001025)2.38229290
104Hypergammaglobulinemia (HP:0010702)2.37814805
105Cardiovascular calcification (HP:0011915)2.36154085
106Premature loss of primary teeth (HP:0006323)2.36137000
107Keratoconjunctivitis (HP:0001096)2.35085417
108Hepatocellular carcinoma (HP:0001402)2.34203729
109Glycosuria (HP:0003076)2.33240609
110Abnormality of urine glucose concentration (HP:0011016)2.33240609
111Abnormal delayed hypersensitivity skin test (HP:0002963)2.30903375
112Arterial thrombosis (HP:0004420)2.30563151
113Interstitial pulmonary disease (HP:0006530)2.30290494
114Gangrene (HP:0100758)2.29976634
115Amyloidosis (HP:0011034)2.29808523
116Increased serum ferritin (HP:0003281)2.27668697
117Stomatitis (HP:0010280)2.26166485
118Cellulitis (HP:0100658)2.25115002
119Encephalitis (HP:0002383)2.25018460
120Inflammation of the large intestine (HP:0002037)2.21205705
121Vomiting (HP:0002013)2.21159872
122Basal ganglia calcification (HP:0002135)2.20216774
123Nasal polyposis (HP:0100582)2.19662329
124Abnormality of vitamin metabolism (HP:0100508)2.19194900
125Spontaneous hematomas (HP:0007420)2.18878684
126Abnormal enzyme/coenzyme activity (HP:0012379)2.18833135
127Alkalosis (HP:0001948)2.17497987
128Opisthotonus (HP:0002179)2.16580948
129Abnormality of T cell number (HP:0011839)2.15886961
130Osteomyelitis (HP:0002754)2.14849867
131Ileus (HP:0002595)2.14109952
132Increased purine levels (HP:0004368)2.11377421
133Hyperuricemia (HP:0002149)2.11377421
134Gastrointestinal inflammation (HP:0004386)2.10866847
135T lymphocytopenia (HP:0005403)2.10270538
136Axonal loss (HP:0003447)2.09658803
137Hydroxyprolinuria (HP:0003080)2.09394832
138Abnormality of proline metabolism (HP:0010907)2.09394832
139Abnormal cartilage morphology (HP:0002763)2.09108165
140Petechiae (HP:0000967)2.08241370
141Increased IgE level (HP:0003212)2.06465224
142Polyneuropathy (HP:0001271)2.06050200
143Hepatosplenomegaly (HP:0001433)2.05556475
144Hypophosphatemic rickets (HP:0004912)2.04427003
145Emphysema (HP:0002097)2.02810007
146Abnormality of the prostate (HP:0008775)2.02735884
147Agammaglobulinemia (HP:0004432)2.02734335
148Systemic lupus erythematosus (HP:0002725)2.02067282
149Pulmonary embolism (HP:0002204)2.01349829
150Megaloblastic anemia (HP:0001889)2.01247146
151Increased neuronal autofluorescent lipopigment (HP:0002074)1.99668684
152Skin nodule (HP:0200036)1.99406116
153Mucopolysacchariduria (HP:0008155)1.98826966
154Urinary glycosaminoglycan excretion (HP:0003541)1.98826966
155Abnormality of alkaline phosphatase activity (HP:0004379)1.98495768
156Abnormality of polysaccharide metabolism (HP:0011012)1.98286751
157Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98286751
158Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98286751
159Restrictive lung disease (HP:0002091)1.97811994
160Hematochezia (HP:0002573)1.95798605
161Joint swelling (HP:0001386)1.94134226
162Back pain (HP:0003418)1.93969863
163Acanthocytosis (HP:0001927)1.93954467
164Confusion (HP:0001289)1.93924587
165Abnormal gallbladder morphology (HP:0012437)1.93467883
166Cerebral hypomyelination (HP:0006808)1.92530547
167Anorexia (HP:0002039)1.91843911
168Abnormality of the pleura (HP:0002103)1.91003768
169Progressive neurologic deterioration (HP:0002344)1.90883438
170Abnormality of the vasculature of the conjunctiva (HP:0008054)1.90426036
171Chronic diarrhea (HP:0002028)1.90182481
172Enlarged kidneys (HP:0000105)1.88929667
173Brushfield spots (HP:0001088)1.88838838
174IgM deficiency (HP:0002850)1.88574098
175Pancreatitis (HP:0001733)1.86769233
176Abnormality of iron homeostasis (HP:0011031)1.86320177
177Methylmalonic aciduria (HP:0012120)1.85624928
178Prolonged neonatal jaundice (HP:0006579)1.85529053
179Gingival bleeding (HP:0000225)1.85458371
180Glomerulopathy (HP:0100820)1.85157303
181Nausea (HP:0002018)1.83308220
182Elevated alkaline phosphatase (HP:0003155)1.81966188
183Neurofibrillary tangles (HP:0002185)1.81732273
184Myocardial infarction (HP:0001658)1.79390951
185Cholelithiasis (HP:0001081)1.79266433
186Cholecystitis (HP:0001082)1.79005968
187Abnormal gallbladder physiology (HP:0012438)1.79005968
188Abnormality of transition element cation homeostasis (HP:0011030)1.76663256
189Hypoglycemic seizures (HP:0002173)1.76272893
190Parakeratosis (HP:0001036)1.73438622
191Acute encephalopathy (HP:0006846)1.72722068
192CNS demyelination (HP:0007305)1.72215016
193Sensorimotor neuropathy (HP:0007141)1.70428898

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.46889953
2STK394.44256632
3TYK23.97079063
4PBK3.67888285
5OXSR13.63805069
6IRAK33.53632764
7BLK3.14985908
8RIPK43.10853709
9MET3.06680966
10MAP3K143.01227369
11WNK42.62382306
12TBK12.59704537
13JAK32.54856559
14EPHA22.53134397
15MAP4K12.50278416
16IKBKE2.48473913
17PRPF4B2.43630614
18JAK12.43550206
19ERBB42.36099071
20TESK22.26989885
21MST42.24002113
22BMPR22.22451666
23IRAK42.17309105
24EPHB12.08611830
25RIPK12.05425062
26GRK71.92049831
27EIF2AK11.88814708
28FGFR41.76234692
29MATK1.73138819
30KIT1.70187935
31TAOK21.67290762
32BCR1.65811961
33BUB11.63761453
34WEE11.62408367
35ERN11.61598914
36IKBKB1.59664313
37FGR1.56056427
38SIK11.53993892
39MAP3K131.53855100
40FGFR21.49028359
41ICK1.42890792
42TTK1.35468753
43FGFR31.32874687
44MST1R1.31645782
45LATS11.29363618
46TGFBR21.28665622
47NME21.28334063
48CSF1R1.26740520
49ABL21.26188972
50ZAP701.25258958
51SYK1.23057363
52JAK21.19503850
53NEK11.19251804
54PIK3CG1.17682604
55WNK31.15262371
56STK38L1.14551537
57PIM21.13546681
58CDC42BPA1.11506309
59MAP3K81.10967039
60PKN11.10731522
61LYN1.10684723
62MOS1.09992676
63PDK21.09741354
64MARK31.08759888
65CSNK1G31.06633293
66TXK1.05783748
67MAP3K11.03345445
68STK101.01190279
69BTK1.00061810
70LIMK10.98591630
71FLT30.98249756
72SMG10.97935185
73CSNK1G10.96841787
74CSNK1A1L0.91238588
75STK160.90095812
76MAP2K20.88084825
77RPS6KB20.88071310
78EIF2AK30.87648711
79TLK10.86938628
80AKT30.85718202
81IRAK10.83298346
82MAPK110.82661155
83PDK40.79634756
84PDK30.79634756
85STK40.77586937
86GSK3A0.76926631
87LCK0.76712142
88MAP3K50.75967042
89MAP3K110.74810254
90CAMK2G0.71889185
91MAP3K30.71408087
92HCK0.70914471
93FES0.69591649
94BMX0.69018759
95CHUK0.67931029
96AURKA0.63330056
97CDK70.62284171
98NEK90.61886434
99EPHA30.61797996
100NEK60.60824789
101LRRK20.60097566
102TEC0.59524907
103ARAF0.59268874
104MELK0.58472478
105TAOK10.57227923
106WNK10.55823790
107STK30.54716484
108CLK10.54697198
109IRAK20.54530138
110PINK10.53737923
111SCYL20.50766381
112PAK10.50747743
113PNCK0.50302376
114CDK40.47914584
115PAK40.47090679
116ERBB20.46195217
117CSNK1E0.46050445
118ROCK20.45684648
119ITK0.45231631
120PIM10.45111631
121FGFR10.44848523
122TSSK60.44769597
123KDR0.44316209
124PTK60.44211643
125STK240.43343140
126CSNK2A20.43187234
127PDK10.42693938
128ACVR1B0.42533253
129SIK30.41415754
130MAP2K30.41192977
131CSNK1G20.40748654
132PDGFRA0.40337953
133EIF2AK20.40311238
134DYRK20.39789575
135MAPKAPK20.39783947
136CDK60.39543146
137PDPK10.39371904
138TRIB30.39322520
139PTK20.39272414
140MTOR0.39170181
141CSNK1D0.38737244
142HIPK20.38298467
143EGFR0.36503221
144PLK10.36464973
145CSK0.35296267
146PKN20.35181566
147ALK0.34095237
148ABL10.33517702
149DDR20.31949988
150AURKB0.31924932
151DAPK30.31024866
152PRKCI0.30957264
153PAK30.30793985
154PAK20.30658380
155CAMK2B0.30406472
156RPS6KA50.28673381
157PRKCD0.28658248
158CSNK2A10.28598374
159PRKCQ0.27605720
160MAPK150.27110945
161GRK60.26290496
162MAPK70.26188629
163ADRBK20.25520092
164CAMK2D0.24884084
165CDK190.24645751
166BRSK20.23062450
167PRKG20.22979791
168TESK10.22802321
169MAPK40.21982803

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.63206993
2Asthma_Homo sapiens_hsa053103.39832871
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.37341704
4Nitrogen metabolism_Homo sapiens_hsa009103.19859905
5Autoimmune thyroid disease_Homo sapiens_hsa053203.18523491
6Graft-versus-host disease_Homo sapiens_hsa053323.09481008
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.95588604
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.90664255
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.84851096
10Leishmaniasis_Homo sapiens_hsa051402.84515745
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71788726
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.55719222
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.53398192
14Type I diabetes mellitus_Homo sapiens_hsa049402.49818731
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44665430
16Arginine biosynthesis_Homo sapiens_hsa002202.43705467
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.41823034
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.34624687
19Tryptophan metabolism_Homo sapiens_hsa003802.31762095
20Antigen processing and presentation_Homo sapiens_hsa046122.31759372
21Fatty acid degradation_Homo sapiens_hsa000712.29487107
22NF-kappa B signaling pathway_Homo sapiens_hsa040642.22282052
23Rheumatoid arthritis_Homo sapiens_hsa053232.22149874
24Butanoate metabolism_Homo sapiens_hsa006502.19698644
25Other glycan degradation_Homo sapiens_hsa005112.14638789
26Influenza A_Homo sapiens_hsa051642.12094884
27Propanoate metabolism_Homo sapiens_hsa006402.11280586
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09908878
29Osteoclast differentiation_Homo sapiens_hsa043802.09435490
30Peroxisome_Homo sapiens_hsa041462.07797110
31Pentose and glucuronate interconversions_Homo sapiens_hsa000402.06424576
32Tuberculosis_Homo sapiens_hsa051522.00314629
33Steroid biosynthesis_Homo sapiens_hsa001001.99574103
34Viral myocarditis_Homo sapiens_hsa054161.97729916
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.93479577
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90706998
37Histidine metabolism_Homo sapiens_hsa003401.89906759
38Fatty acid elongation_Homo sapiens_hsa000621.89900788
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.89441506
40Folate biosynthesis_Homo sapiens_hsa007901.87401205
41Pertussis_Homo sapiens_hsa051331.85348882
42Sulfur metabolism_Homo sapiens_hsa009201.83183242
43Herpes simplex infection_Homo sapiens_hsa051681.82227038
44Complement and coagulation cascades_Homo sapiens_hsa046101.79042997
45Fatty acid metabolism_Homo sapiens_hsa012121.76985088
46Measles_Homo sapiens_hsa051621.75229150
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73250042
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72890361
49Chemical carcinogenesis_Homo sapiens_hsa052041.68201077
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67380213
51Toxoplasmosis_Homo sapiens_hsa051451.67335475
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66724530
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.62670678
54beta-Alanine metabolism_Homo sapiens_hsa004101.61295830
55Selenocompound metabolism_Homo sapiens_hsa004501.60783923
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.58785199
57Lysosome_Homo sapiens_hsa041421.57801466
58Pyruvate metabolism_Homo sapiens_hsa006201.57799823
59Malaria_Homo sapiens_hsa051441.55840738
60Legionellosis_Homo sapiens_hsa051341.54928908
61PPAR signaling pathway_Homo sapiens_hsa033201.54836413
62Cysteine and methionine metabolism_Homo sapiens_hsa002701.51550937
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.50590957
64Biosynthesis of amino acids_Homo sapiens_hsa012301.49879870
65Primary immunodeficiency_Homo sapiens_hsa053401.49766824
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49016676
67TNF signaling pathway_Homo sapiens_hsa046681.47813838
68Phagosome_Homo sapiens_hsa041451.43757515
69Carbon metabolism_Homo sapiens_hsa012001.42935016
70African trypanosomiasis_Homo sapiens_hsa051431.41187343
71NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40337522
72Vitamin B6 metabolism_Homo sapiens_hsa007501.40266350
73Retinol metabolism_Homo sapiens_hsa008301.39194350
74One carbon pool by folate_Homo sapiens_hsa006701.38844657
75B cell receptor signaling pathway_Homo sapiens_hsa046621.37074143
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36220635
77Hematopoietic cell lineage_Homo sapiens_hsa046401.33807337
78Hepatitis C_Homo sapiens_hsa051601.33503093
79Caffeine metabolism_Homo sapiens_hsa002321.32455755
80* Arginine and proline metabolism_Homo sapiens_hsa003301.28782192
81* Glutathione metabolism_Homo sapiens_hsa004801.26978843
82Phenylalanine metabolism_Homo sapiens_hsa003601.26622212
83Fat digestion and absorption_Homo sapiens_hsa049751.26023186
84Tyrosine metabolism_Homo sapiens_hsa003501.21392377
85Vitamin digestion and absorption_Homo sapiens_hsa049771.19679212
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12540031
87Sulfur relay system_Homo sapiens_hsa041221.09780917
88Bile secretion_Homo sapiens_hsa049761.08657097
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05857487
90Starch and sucrose metabolism_Homo sapiens_hsa005001.05742270
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04137775
92Jak-STAT signaling pathway_Homo sapiens_hsa046301.03277587
93Glycosaminoglycan degradation_Homo sapiens_hsa005311.02364420
94Chemokine signaling pathway_Homo sapiens_hsa040621.01362308
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01313323
96Salmonella infection_Homo sapiens_hsa051320.99399348
97Apoptosis_Homo sapiens_hsa042100.99306578
98Hepatitis B_Homo sapiens_hsa051610.97603573
99Staphylococcus aureus infection_Homo sapiens_hsa051500.96425564
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88773471
101Epstein-Barr virus infection_Homo sapiens_hsa051690.86433957
102Pentose phosphate pathway_Homo sapiens_hsa000300.84469490
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82831476
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82046940
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75345028
106Shigellosis_Homo sapiens_hsa051310.73656052
107ABC transporters_Homo sapiens_hsa020100.70642819
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70061865
109* Metabolic pathways_Homo sapiens_hsa011000.66919651
110Glycerolipid metabolism_Homo sapiens_hsa005610.65221982
111Proteasome_Homo sapiens_hsa030500.64957770
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.63520997
113Lysine degradation_Homo sapiens_hsa003100.61190687
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60218421
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60199501
116Acute myeloid leukemia_Homo sapiens_hsa052210.57663406
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55500428
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54680355
119Fructose and mannose metabolism_Homo sapiens_hsa000510.53493652
120T cell receptor signaling pathway_Homo sapiens_hsa046600.52499387
121Linoleic acid metabolism_Homo sapiens_hsa005910.52017337
122Fatty acid biosynthesis_Homo sapiens_hsa000610.51938182
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49214514
124Viral carcinogenesis_Homo sapiens_hsa052030.48258231
125HTLV-I infection_Homo sapiens_hsa051660.48115413
126Bladder cancer_Homo sapiens_hsa052190.47936107
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47683174
128Amoebiasis_Homo sapiens_hsa051460.44986555
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43967764
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42074871
131Sphingolipid metabolism_Homo sapiens_hsa006000.40684708
132Prolactin signaling pathway_Homo sapiens_hsa049170.38786903
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.37840281
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35185443
135Arachidonic acid metabolism_Homo sapiens_hsa005900.32776943
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32659271
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32185163
138Ether lipid metabolism_Homo sapiens_hsa005650.31793381
139Galactose metabolism_Homo sapiens_hsa000520.31559629
140Pancreatic cancer_Homo sapiens_hsa052120.30910525
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29390776
142Renin-angiotensin system_Homo sapiens_hsa046140.27255809
143HIF-1 signaling pathway_Homo sapiens_hsa040660.27137699
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26317807
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25701212
146Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25182159
147Pyrimidine metabolism_Homo sapiens_hsa002400.24772956
148Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24195504
149Protein export_Homo sapiens_hsa030600.23266232
150Oxidative phosphorylation_Homo sapiens_hsa001900.23066384
151Mismatch repair_Homo sapiens_hsa034300.22230899
152Prion diseases_Homo sapiens_hsa050200.21632211
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.20173260
154Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16104622
155RNA polymerase_Homo sapiens_hsa030200.16014424
156Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14057465
157Chronic myeloid leukemia_Homo sapiens_hsa052200.13793523
158Systemic lupus erythematosus_Homo sapiens_hsa053220.13739032
159Mineral absorption_Homo sapiens_hsa049780.13250530
160Glycerophospholipid metabolism_Homo sapiens_hsa005640.13084333
161Platelet activation_Homo sapiens_hsa046110.13064599
162Vibrio cholerae infection_Homo sapiens_hsa051100.13033183
163DNA replication_Homo sapiens_hsa030300.11369891
164Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.10965964
165Parkinsons disease_Homo sapiens_hsa050120.08278486
166Protein digestion and absorption_Homo sapiens_hsa049740.03463531
167Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.02780506
168Ribosome_Homo sapiens_hsa030100.01193556
169Nucleotide excision repair_Homo sapiens_hsa03420-0.0318066
170Tight junction_Homo sapiens_hsa04530-0.0284470
171Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0171899
172RNA transport_Homo sapiens_hsa03013-0.0141345

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