ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.65773541
2	proteasome assembly (GO:0043248)	5.73498437
3	cytidine deamination (GO:0009972)	5.37232724
4	cytidine metabolic process (GO:0046087)	5.37232724
5	cytidine catabolic process (GO:0006216)	5.37232724
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.98150796
7	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.77540434
8	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	4.40674578
9	regulation of cellular amino acid metabolic process (GO:0006521)	4.26578490
10	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.25836342
11	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.25836342
12	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	4.08329596
13	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	4.00062007
14	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	4.00062007
15	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	4.00062007
16	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.98964872
17	negative regulation of ligase activity (GO:0051352)	3.98964872
18	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.96598545
19	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.96598545
20	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.96450414
21	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.89981312
22	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.86962054
23	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.86612142
24	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.83697670
25	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.78958354
26	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.78958354
27	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.73000306
28	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.68230265
29	T cell migration (GO:0072678)	3.64787929
30	regulation of T cell tolerance induction (GO:0002664)	3.57849995
31	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.55181517
32	B cell mediated immunity (GO:0019724)	3.53205650
33	immunoglobulin mediated immune response (GO:0016064)	3.52230846
34	cullin deneddylation (GO:0010388)	3.46555210
35	protein deneddylation (GO:0000338)	3.36781519
36	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	3.26397399
37	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.23000574
38	chaperone-mediated protein transport (GO:0072321)	3.21614067
39	ribosome assembly (GO:0042255)	3.19059934
40	regulation of chronic inflammatory response (GO:0002676)	3.10914340
41	protein neddylation (GO:0045116)	3.10808589
42	positive regulation of ligase activity (GO:0051351)	3.09648738
43	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.07764380
44	regulation of cellular amine metabolic process (GO:0033238)	3.06812560
45	dendritic cell chemotaxis (GO:0002407)	3.04666885
46	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	3.04253104
47	respiratory chain complex IV assembly (GO:0008535)	3.01448933
48	positive regulation of cell cycle arrest (GO:0071158)	2.97817782
49	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.94485027
50	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.92417479
51	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.91170192
52	rRNA modification (GO:0000154)	2.90296640
53	regulation of tolerance induction (GO:0002643)	2.88136303
54	positive regulation of defense response to virus by host (GO:0002230)	2.86893052
55	negative regulation of protein ubiquitination (GO:0031397)	2.86825808
56	cyclooxygenase pathway (GO:0019371)	2.84486099
57	regulation of antigen processing and presentation (GO:0002577)	2.84027598
58	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.81860990
59	isotype switching (GO:0045190)	2.81860990
60	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.81860990
61	regulation of interleukin-1 beta secretion (GO:0050706)	2.80555372
62	positive regulation of T-helper 1 type immune response (GO:0002827)	2.79197446
63	response to interferon-beta (GO:0035456)	2.79130494
64	positive regulation of monocyte chemotaxis (GO:0090026)	2.79080260
65	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.77815405
66	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.75799615
67	positive regulation of tolerance induction (GO:0002645)	2.73550295
68	positive regulation of interleukin-1 secretion (GO:0050716)	2.73526782
69	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.73199109
70	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.71023680
71	regulation of T-helper 1 type immune response (GO:0002825)	2.70793003
72	negative regulation of protein modification by small protein conjugation or removal (GO:1903321)	2.68789647
73	regulation of ligase activity (GO:0051340)	2.68571562
74	regulation of B cell receptor signaling pathway (GO:0050855)	2.67624987
75	purine nucleobase biosynthetic process (GO:0009113)	2.67260054
76	IMP biosynthetic process (GO:0006188)	2.67043404
77	tryptophan metabolic process (GO:0006568)	2.64327609
78	purine-containing compound salvage (GO:0043101)	2.63454792
79	myeloid dendritic cell activation (GO:0001773)	2.62828277
80	cytochrome complex assembly (GO:0017004)	2.62799437
81	kynurenine metabolic process (GO:0070189)	2.62208986
82	tolerance induction (GO:0002507)	2.61700438
83	water-soluble vitamin biosynthetic process (GO:0042364)	2.61246878
84	lymphocyte chemotaxis (GO:0048247)	2.59139974
85	negative regulation of T cell apoptotic process (GO:0070233)	2.57179968
86	platelet dense granule organization (GO:0060155)	2.56512891
87	regulation of cellular extravasation (GO:0002691)	2.56043070
88	ATP synthesis coupled proton transport (GO:0015986)	2.54363567
89	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.54363567
90	negative regulation of cell cycle G1/S phase transition (GO:1902807)	2.51329696
91	negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)	2.51329696
92	DNA damage response, detection of DNA damage (GO:0042769)	2.49061267
93	tryptophan catabolic process (GO:0006569)	2.48236419
94	indole-containing compound catabolic process (GO:0042436)	2.48236419
95	indolalkylamine catabolic process (GO:0046218)	2.48236419
96	dendritic cell migration (GO:0036336)	2.48182896
97	mitochondrial RNA metabolic process (GO:0000959)	2.47414367
98	purine nucleotide salvage (GO:0032261)	2.47294699
99	positive regulation of T cell chemotaxis (GO:0010820)	2.47288049
100	regulation of T cell chemotaxis (GO:0010819)	2.47288049

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.90614757
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.35982469
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.12194914
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.62158394
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.55279299
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.44693557
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.32060256
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.18046259
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.09603837
10	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	3.07692686
11	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	3.05467389
12	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.03816961
13	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.92144430
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.89687530
15	VDR_22108803_ChIP-Seq_LS180_Human	2.65163298
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.63412789
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.62043938
18	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.50602328
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.46462751
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.40793066
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.38691991
22	E2F7_22180533_ChIP-Seq_HELA_Human	2.37409688
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.26823504
24	ELK1_19687146_ChIP-ChIP_HELA_Human	2.24246084
25	FOXP3_21729870_ChIP-Seq_TREG_Human	2.23647750
26	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	2.14134638
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.13513124
28	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.12351452
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.03998343
30	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.97935071
31	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.97782328
32	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.86992333
33	MYB_26560356_Chip-Seq_TH2_Human	1.83686460
34	DCP1A_22483619_ChIP-Seq_HELA_Human	1.73583056
35	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.73515901
36	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.72446840
37	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.67503180
38	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.66832037
39	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.62954529
40	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.61053799
41	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.57608740
42	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.57209412
43	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.55821482
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.54335369
45	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.53670803
46	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.52708084
47	GATA3_26560356_Chip-Seq_TH2_Human	1.50170920
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.49988241
49	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.48726054
50	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.47793143
51	SPI1_23547873_ChIP-Seq_NB4_Human	1.47335907
52	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.43545735
53	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.33222886
54	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.30756798
55	ZNF274_21170338_ChIP-Seq_K562_Hela	1.30594261
56	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.30084640
57	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.29667177
58	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29003826
59	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.22844833
60	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.21609409
61	GABP_19822575_ChIP-Seq_HepG2_Human	1.19957249
62	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.12158605
63	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.10548875
64	MYB_26560356_Chip-Seq_TH1_Human	1.08294312
65	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.05114207
66	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.04808958
67	CIITA_25753668_ChIP-Seq_RAJI_Human	1.01669679
68	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.00188206
69	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.99412048
70	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.98253232
71	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.98247675
72	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.97085461
73	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.95897683
74	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.95039404
75	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.95006919
76	MYC_18940864_ChIP-ChIP_HL60_Human	0.94892226
77	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.94859211
78	GATA3_27048872_Chip-Seq_THYMUS_Human	0.94037298
79	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.93989505
80	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90496804
81	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90496804
82	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.90331900
83	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.89107540
84	AR_20517297_ChIP-Seq_VCAP_Human	0.87409820
85	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.86660784
86	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.85771232
87	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.85006141
88	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.84454048
89	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.84454048
90	TFEB_21752829_ChIP-Seq_HELA_Human	0.82026003
91	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.80926013
92	TP53_22573176_ChIP-Seq_HFKS_Human	0.80686136
93	TTF2_22483619_ChIP-Seq_HELA_Human	0.80550984
94	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.80361210
95	RUNX_20019798_ChIP-Seq_JUKART_Human	0.79489878
96	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.78624105
97	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.78469104
98	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.77706645
99	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.76563930
100	XRN2_22483619_ChIP-Seq_HELA_Human	0.76134815

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.06178977
2	MP0001835_abnormal_antigen_presentation	3.89895675
3	MP0002138_abnormal_hepatobiliary_system	3.54671096
4	MP0009785_altered_susceptibility_to	3.40180816
5	MP0002148_abnormal_hypersensitivity_rea	3.20931211
6	MP0005167_abnormal_blood-brain_barrier	2.92819228
7	MP0003724_increased_susceptibility_to	2.74438182
8	MP0005000_abnormal_immune_tolerance	2.74387090
9	MP0001790_abnormal_immune_system	2.72571455
10	MP0005387_immune_system_phenotype	2.72571455
11	MP0004147_increased_porphyrin_level	2.62296286
12	MP0001800_abnormal_humoral_immune	2.58103871
13	MP0003806_abnormal_nucleotide_metabolis	2.46961109
14	MP0002102_abnormal_ear_morphology	2.41262296
15	MP0000685_abnormal_immune_system	2.27012757
16	MP0002723_abnormal_immune_serum	2.18897135
17	MP0009333_abnormal_splenocyte_physiolog	2.18112771
18	MP0002452_abnormal_antigen_presenting	2.18099208
19	MP0003866_abnormal_defecation	2.03642437
20	MP0000465_gastrointestinal_hemorrhage	1.99788060
21	MP0010094_abnormal_chromosome_stability	1.99518167
22	MP0002166_altered_tumor_susceptibility	1.90913574
23	MP0001819_abnormal_immune_cell	1.90047101
24	MP0002420_abnormal_adaptive_immunity	1.88746569
25	MP0005025_abnormal_response_to	1.84578183
26	MP0009764_decreased_sensitivity_to	1.83661221
27	MP0010368_abnormal_lymphatic_system	1.82388261
28	MP0010155_abnormal_intestine_physiology	1.81362251
29	MP0000372_irregular_coat_pigmentation	1.72570400
30	MP0002006_tumorigenesis	1.70048492
31	MP0006082_CNS_inflammation	1.66301796
32	MP0001845_abnormal_inflammatory_respons	1.60774120
33	MP0002419_abnormal_innate_immunity	1.58613077
34	MP0003718_maternal_effect	1.56069342
35	MP0003436_decreased_susceptibility_to	1.54343773
36	MP0008007_abnormal_cellular_replicative	1.53413080
37	MP0003763_abnormal_thymus_physiology	1.48894570
38	MP0002398_abnormal_bone_marrow	1.46370986
39	MP0000689_abnormal_spleen_morphology	1.44210505
40	MP0006036_abnormal_mitochondrial_physio	1.43446096
41	MP0000343_altered_response_to	1.42112944
42	MP0002405_respiratory_system_inflammati	1.39683158
43	MP0005084_abnormal_gallbladder_morpholo	1.38242247
44	MP0002277_abnormal_respiratory_mucosa	1.38060278
45	MP0000716_abnormal_immune_system	1.37913714
46	MP0009697_abnormal_copulation	1.37787317
47	MP0003195_calcinosis	1.33411372
48	MP0002722_abnormal_immune_system	1.31123584
49	MP0004957_abnormal_blastocyst_morpholog	1.30195925
50	MP0003693_abnormal_embryo_hatching	1.29754610
51	MP0008058_abnormal_DNA_repair	1.23430519
52	MP0001879_abnormal_lymphatic_vessel	1.21648164
53	MP0008875_abnormal_xenobiotic_pharmacok	1.21624747
54	MP0002429_abnormal_blood_cell	1.20886765
55	MP0008469_abnormal_protein_level	1.20083644
56	MP0003186_abnormal_redox_activity	1.19547858
57	MP0004883_abnormal_blood_vessel	1.19546428
58	MP0006054_spinal_hemorrhage	1.16142045
59	MP0001873_stomach_inflammation	1.15811999
60	MP0006035_abnormal_mitochondrial_morpho	1.13086342
61	MP0003448_altered_tumor_morphology	1.12678381
62	MP0001243_abnormal_dermal_layer	1.11205096
63	MP0005310_abnormal_salivary_gland	1.09675464
64	MP0003786_premature_aging	1.06314401
65	MP0001533_abnormal_skeleton_physiology	1.03737940
66	MP0005464_abnormal_platelet_physiology	1.01494396
67	MP0001853_heart_inflammation	1.01204341
68	MP0006072_abnormal_retinal_apoptosis	0.98795395
69	MP0000249_abnormal_blood_vessel	0.98080971
70	MP0001986_abnormal_taste_sensitivity	0.97980875
71	MP0005379_endocrine/exocrine_gland_phen	0.96762120
72	MP0002163_abnormal_gland_morphology	0.96704418
73	MP0003646_muscle_fatigue	0.93334146
74	MP0001542_abnormal_bone_strength	0.92414615
75	MP0005165_increased_susceptibility_to	0.91830416
76	MP0005166_decreased_susceptibility_to	0.90436340
77	MP0001764_abnormal_homeostasis	0.90392211
78	MP0003077_abnormal_cell_cycle	0.88769477
79	MP0005645_abnormal_hypothalamus_physiol	0.85934309
80	MP0002139_abnormal_hepatobiliary_system	0.83719177
81	MP0004885_abnormal_endolymph	0.81742202
82	MP0003075_altered_response_to	0.80612596
83	MP0003303_peritoneal_inflammation	0.75976435
84	MP0000703_abnormal_thymus_morphology	0.75743921
85	MP0008872_abnormal_physiological_respon	0.75617096
86	MP0004947_skin_inflammation	0.75009856
87	MP0003111_abnormal_nucleus_morphology	0.73651129
88	MP0005332_abnormal_amino_acid	0.72463638
89	MP0003045_fibrosis	0.72100611
90	MP0002736_abnormal_nociception_after	0.71956309
91	MP0009763_increased_sensitivity_to	0.67226258
92	MP0005395_other_phenotype	0.65747104
93	MP0002933_joint_inflammation	0.65253811
94	MP0005319_abnormal_enzyme/_coenzyme	0.63826577
95	MP0005360_urolithiasis	0.61755255
96	MP0002019_abnormal_tumor_incidence	0.61278848
97	MP0005367_renal/urinary_system_phenotyp	0.61124003
98	MP0000516_abnormal_urinary_system	0.61124003
99	MP0008873_increased_physiological_sensi	0.61099211
100	MP0009765_abnormal_xenobiotic_induced	0.60998686

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.27615500
2	IgM deficiency (HP:0002850)	3.75832818
3	Elevated erythrocyte sedimentation rate (HP:0003565)	3.41648030
4	Mitochondrial inheritance (HP:0001427)	3.39143367
5	Abnormality of B cell number (HP:0010975)	3.35323008
6	Prostate neoplasm (HP:0100787)	3.34025708
7	Hepatocellular necrosis (HP:0001404)	3.23291269
8	Abnormality of T cell physiology (HP:0011840)	3.20214173
9	Acute necrotizing encephalopathy (HP:0006965)	3.19616199
10	Abnormality of the prostate (HP:0008775)	3.18974172
11	Increased CSF lactate (HP:0002490)	3.18661338
12	B lymphocytopenia (HP:0010976)	3.18082138
13	Recurrent bronchitis (HP:0002837)	3.11162309
14	Increased IgM level (HP:0003496)	2.99135163
15	Type I transferrin isoform profile (HP:0003642)	2.95939987
16	Hepatic necrosis (HP:0002605)	2.95837089
17	Abnormality of T cells (HP:0002843)	2.94947775
18	Autoimmune hemolytic anemia (HP:0001890)	2.90919880
19	IgA deficiency (HP:0002720)	2.86951435
20	Lipid accumulation in hepatocytes (HP:0006561)	2.85598963
21	Aplastic anemia (HP:0001915)	2.85057583
22	Abnormality of T cell number (HP:0011839)	2.81047946
23	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.80350677
24	Increased hepatocellular lipid droplets (HP:0006565)	2.80126688
25	Abnormal mitochondria in muscle tissue (HP:0008316)	2.79738363
26	Increased serum lactate (HP:0002151)	2.76646235
27	Acute encephalopathy (HP:0006846)	2.76196275
28	Progressive macrocephaly (HP:0004481)	2.64694536
29	T lymphocytopenia (HP:0005403)	2.59512622
30	Methylmalonic aciduria (HP:0012120)	2.53316871
31	Stomatitis (HP:0010280)	2.47621924
32	Stomach cancer (HP:0012126)	2.46405671
33	Cerebral hemorrhage (HP:0001342)	2.43907713
34	Lactic acidosis (HP:0003128)	2.43151196
35	Cerebral palsy (HP:0100021)	2.40870600
36	Cerebral edema (HP:0002181)	2.39515109
37	Abnormality of the pons (HP:0007361)	2.31028354
38	Panhypogammaglobulinemia (HP:0003139)	2.27183718
39	Hypoplasia of the pons (HP:0012110)	2.26757696
40	Abnormal protein glycosylation (HP:0012346)	2.26575586
41	Abnormal glycosylation (HP:0012345)	2.26575586
42	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.26575586
43	Abnormal protein N-linked glycosylation (HP:0012347)	2.26575586
44	Exertional dyspnea (HP:0002875)	2.25008564
45	Agammaglobulinemia (HP:0004432)	2.22179721
46	Methylmalonic acidemia (HP:0002912)	2.21527776
47	Redundant skin (HP:0001582)	2.20567451
48	Renal Fanconi syndrome (HP:0001994)	2.20477299
49	Myositis (HP:0100614)	2.16620114
50	Autoimmune thrombocytopenia (HP:0001973)	2.16551370
51	Vasculitis (HP:0002633)	2.15626748
52	Reduced antithrombin III activity (HP:0001976)	2.14847617
53	Eosinophilia (HP:0001880)	2.14195982
54	Bronchitis (HP:0012387)	2.13968672
55	Chronic diarrhea (HP:0002028)	2.12923000
56	Congenital, generalized hypertrichosis (HP:0004540)	2.11227873
57	Recurrent bacterial skin infections (HP:0005406)	2.08955058
58	Respiratory failure (HP:0002878)	2.08824587
59	Retrobulbar optic neuritis (HP:0100654)	2.08239495
60	Optic neuritis (HP:0100653)	2.08239495
61	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.08064297
62	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.08064297
63	Joint swelling (HP:0001386)	2.07910894
64	Recurrent abscess formation (HP:0002722)	2.07676839
65	Recurrent viral infections (HP:0004429)	2.07607245
66	Hemoptysis (HP:0002105)	2.06874061
67	Hematochezia (HP:0002573)	2.05918458
68	Abolished electroretinogram (ERG) (HP:0000550)	2.05757874
69	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.05636889
70	Parakeratosis (HP:0001036)	2.04396527
71	Neutropenia (HP:0001875)	2.04193139
72	Pancytopenia (HP:0001876)	2.01631912
73	Birth length less than 3rd percentile (HP:0003561)	2.01348012
74	Increased intramyocellular lipid droplets (HP:0012240)	2.00697991
75	Lethargy (HP:0001254)	1.99560944
76	Abnormality of eosinophils (HP:0001879)	1.96028728
77	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.95276088
78	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.95197643
79	3-Methylglutaconic aciduria (HP:0003535)	1.94951070
80	Abnormality of methionine metabolism (HP:0010901)	1.93075238
81	Colitis (HP:0002583)	1.92071582
82	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.92040972
83	Carpal bone hypoplasia (HP:0001498)	1.91902052
84	Chronic mucocutaneous candidiasis (HP:0002728)	1.87753914
85	Recurrent cutaneous fungal infections (HP:0011370)	1.87753914
86	Abnormality of male internal genitalia (HP:0000022)	1.87741950
87	Neuroendocrine neoplasm (HP:0100634)	1.85226192
88	Meningitis (HP:0001287)	1.84543159
89	Gastrointestinal stroma tumor (HP:0100723)	1.83787835
90	Eczematoid dermatitis (HP:0000976)	1.83544781
91	Paralysis (HP:0003470)	1.82617295
92	Orchitis (HP:0100796)	1.79058653
93	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.78595983
94	Abnormality of alanine metabolism (HP:0010916)	1.78595983
95	Hyperalaninemia (HP:0003348)	1.78595983
96	Opisthotonus (HP:0002179)	1.77890897
97	Glucose intolerance (HP:0000833)	1.76851521
98	Granulocytopenia (HP:0001913)	1.76498693
99	Increased muscle lipid content (HP:0009058)	1.76301745
100	Palpitations (HP:0001962)	1.76070897

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.78597079
2	TIE1	3.77121387
3	VRK2	3.38128099
4	TLK1	3.33145148
5	MST4	2.78840887
6	KDR	2.71473777
7	TSSK6	2.71059683
8	BUB1	2.67202581
9	EIF2AK3	2.65108696
10	VRK1	2.63932568
11	TESK2	2.57595971
12	EIF2AK1	2.44652349
13	ADRBK2	2.39557020
14	TXK	2.38321243
15	BMPR2	2.24313320
16	RIPK4	2.20498051
17	GRK1	2.20046694
18	SRPK1	2.06733626
19	BCKDK	1.75761285
20	NUAK1	1.75701924
21	MAP3K12	1.46936080
22	PLK3	1.44991207
23	TEC	1.43452540
24	STK16	1.33778615
25	PLK4	1.33602291
26	TAOK3	1.33255440
27	TAF1	1.26559599
28	TRIM28	1.25486961
29	GRK7	1.19678564
30	BMPR1B	1.16652268
31	MAP4K2	1.14141617
32	EPHB2	1.12178326
33	NEK1	1.10164689
34	IKBKB	1.08674466
35	TBK1	1.07964085
36	PBK	1.07754137
37	OXSR1	1.07469223
38	BCR	1.02576576
39	DAPK1	1.01478393
40	LIMK1	0.95850179
41	MAP4K1	0.93863718
42	TESK1	0.93608969
43	CDK8	0.93331400
44	KIT	0.92162854
45	SYK	0.91736467
46	MYLK	0.89120728
47	STK39	0.88201016
48	EIF2AK2	0.84534969
49	IRAK3	0.83409979
50	JAK3	0.80192603
51	FES	0.78028982
52	IKBKE	0.76408365
53	WEE1	0.75101101
54	PAK4	0.74198867
55	MKNK1	0.74109206
56	ITK	0.70061500
57	CSNK1G3	0.69158661
58	MKNK2	0.66462193
59	WNK3	0.65420286
60	FRK	0.64021920
61	TTK	0.60969973
62	CDC7	0.60255403
63	MAP3K14	0.58324153
64	PINK1	0.57848817
65	SIK3	0.57214812
66	RPS6KA5	0.57113034
67	NME1	0.56634533
68	MATK	0.56016842
69	PASK	0.55223816
70	CSNK1A1L	0.54977396
71	INSRR	0.54004031
72	CSNK1G1	0.53923025
73	GRK6	0.53553423
74	TYK2	0.51947484
75	ALK	0.51563180
76	PNCK	0.50670025
77	CDK9	0.49766209
78	PLK1	0.49713843
79	CSNK1G2	0.47791563
80	PLK2	0.47112401
81	DAPK3	0.46508046
82	PIK3CA	0.46354411
83	LCK	0.46286433
84	BLK	0.45592616
85	TGFBR1	0.44850582
86	CSF1R	0.44738824
87	IRAK4	0.44421403
88	PDK2	0.43719495
89	LYN	0.41945347
90	DYRK2	0.41328273
91	PRKCQ	0.39351886
92	MAPKAPK3	0.39226071
93	ACVR1B	0.39185776
94	AURKB	0.38929002
95	NME2	0.38269322
96	BTK	0.38158510
97	FGR	0.37792359
98	MAPKAPK5	0.36173860
99	MAP3K9	0.34677127
100	PIM1	0.33370143

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.71552200
2	Allograft rejection_Homo sapiens_hsa05330	3.16788445
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.07882466
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.99759296
5	Type I diabetes mellitus_Homo sapiens_hsa04940	2.71146959
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.70249802
7	Asthma_Homo sapiens_hsa05310	2.64364764
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.60321506
9	Antigen processing and presentation_Homo sapiens_hsa04612	2.43619993
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.16886388
11	DNA replication_Homo sapiens_hsa03030	2.15174973
12	Mismatch repair_Homo sapiens_hsa03430	2.12014628
13	Rheumatoid arthritis_Homo sapiens_hsa05323	2.06426070
14	Parkinsons disease_Homo sapiens_hsa05012	2.01348833
15	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.90977310
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.90415676
17	RNA polymerase_Homo sapiens_hsa03020	1.89185584
18	Protein export_Homo sapiens_hsa03060	1.86635484
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.84875021
20	Homologous recombination_Homo sapiens_hsa03440	1.74882837
21	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.47662380
22	Viral myocarditis_Homo sapiens_hsa05416	1.43535071
23	Glutathione metabolism_Homo sapiens_hsa00480	1.35819507
24	One carbon pool by folate_Homo sapiens_hsa00670	1.31599326
25	Leishmaniasis_Homo sapiens_hsa05140	1.29969743
26	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.29151908
27	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.24803239
28	Spliceosome_Homo sapiens_hsa03040	1.23474184
29	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.23389073
30	Sulfur metabolism_Homo sapiens_hsa00920	1.21794835
31	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.21406504
32	Alzheimers disease_Homo sapiens_hsa05010	1.15094009
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.14111560
34	Basal transcription factors_Homo sapiens_hsa03022	1.10392153
35	Propanoate metabolism_Homo sapiens_hsa00640	1.09765913
36	RNA degradation_Homo sapiens_hsa03018	1.09470417
37	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.06697741
38	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.06355656
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.06252702
40	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.04352740
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.03082747
42	Huntingtons disease_Homo sapiens_hsa05016	1.00344995
43	Herpes simplex infection_Homo sapiens_hsa05168	0.99518832
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.99027103
45	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.96469386
46	Purine metabolism_Homo sapiens_hsa00230	0.93721786
47	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.92960595
48	Non-homologous end-joining_Homo sapiens_hsa03450	0.92491259
49	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.91487348
50	Legionellosis_Homo sapiens_hsa05134	0.89212806
51	RNA transport_Homo sapiens_hsa03013	0.88448364
52	Base excision repair_Homo sapiens_hsa03410	0.87935316
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.84142714
54	African trypanosomiasis_Homo sapiens_hsa05143	0.83216946
55	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.82063390
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.81424707
57	Fanconi anemia pathway_Homo sapiens_hsa03460	0.78342154
58	Measles_Homo sapiens_hsa05162	0.77361385
59	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.76952366
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.69482263
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67918327
62	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.67866957
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.65902134
64	Influenza A_Homo sapiens_hsa05164	0.63398663
65	Fatty acid elongation_Homo sapiens_hsa00062	0.60308915
66	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.56847303
67	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.55976625
68	Ribosome_Homo sapiens_hsa03010	0.55233024
69	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.53301486
70	Peroxisome_Homo sapiens_hsa04146	0.52721323
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.52394138
72	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.51555322
73	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49844880
74	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.49148310
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48462493
76	Tuberculosis_Homo sapiens_hsa05152	0.48166302
77	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47704058
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.47225830
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.47214955
80	Apoptosis_Homo sapiens_hsa04210	0.44619551
81	Carbon metabolism_Homo sapiens_hsa01200	0.43574097
82	Toxoplasmosis_Homo sapiens_hsa05145	0.40595200
83	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.39952636
84	Pertussis_Homo sapiens_hsa05133	0.37694542
85	Pyruvate metabolism_Homo sapiens_hsa00620	0.35888743
86	Metabolic pathways_Homo sapiens_hsa01100	0.35340126
87	Phagosome_Homo sapiens_hsa04145	0.35047776
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.33003315
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.31647566
90	Shigellosis_Homo sapiens_hsa05131	0.31484867
91	Phototransduction_Homo sapiens_hsa04744	0.31469547
92	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.30008097
93	Caffeine metabolism_Homo sapiens_hsa00232	0.29759332
94	Salmonella infection_Homo sapiens_hsa05132	0.29367163
95	HTLV-I infection_Homo sapiens_hsa05166	0.28456287
96	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.25995004
97	Cell cycle_Homo sapiens_hsa04110	0.25317250
98	Osteoclast differentiation_Homo sapiens_hsa04380	0.24261380
99	Malaria_Homo sapiens_hsa05144	0.21967275
100	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.21490891

LAP3P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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