LAPTM4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.28306521
2COPI coating of Golgi vesicle (GO:0048205)4.28306521
3apoptotic cell clearance (GO:0043277)4.06682719
4protein heterotrimerization (GO:0070208)3.92424664
5regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.77025614
6extracellular fibril organization (GO:0043206)3.76591641
7sequestering of extracellular ligand from receptor (GO:0035581)3.73496648
8collagen fibril organization (GO:0030199)3.62009530
9regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.49665550
10cell adhesion mediated by integrin (GO:0033627)3.49361483
11desmosome organization (GO:0002934)3.42643924
12vascular endothelial growth factor signaling pathway (GO:0038084)3.37651536
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.34552620
14basement membrane organization (GO:0071711)3.23810944
15endodermal cell differentiation (GO:0035987)3.20690933
16type B pancreatic cell proliferation (GO:0044342)3.18478238
17fibril organization (GO:0097435)3.18062031
18COPII vesicle coating (GO:0048208)3.14326403
19gap junction assembly (GO:0016264)3.12826870
20plasma membrane repair (GO:0001778)3.12524036
21protein retention in ER lumen (GO:0006621)3.11994376
22epithelial cell-cell adhesion (GO:0090136)3.06602437
23negative regulation of fatty acid transport (GO:2000192)3.04288717
24protein maturation by protein folding (GO:0022417)3.03187121
25positive regulation of fatty acid beta-oxidation (GO:0032000)3.03069860
26low-density lipoprotein particle clearance (GO:0034383)3.01129955
27endothelium development (GO:0003158)2.97610228
28transcytosis (GO:0045056)2.97553731
29glomerular basement membrane development (GO:0032836)2.97371975
30L-serine transport (GO:0015825)2.96319863
31keratan sulfate catabolic process (GO:0042340)2.95712308
32collagen metabolic process (GO:0032963)2.95265913
33bundle of His cell to Purkinje myocyte communication (GO:0086069)2.93960970
34skin morphogenesis (GO:0043589)2.92188031
35activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.91093950
36chondrocyte proliferation (GO:0035988)2.90990609
37protein localization to endosome (GO:0036010)2.90595174
38collagen catabolic process (GO:0030574)2.89278408
39cellular response to vitamin (GO:0071295)2.88872168
40regulation of integrin-mediated signaling pathway (GO:2001044)2.88807723
41multicellular organismal macromolecule metabolic process (GO:0044259)2.87775792
42hemidesmosome assembly (GO:0031581)2.86025250
43cell migration involved in sprouting angiogenesis (GO:0002042)2.84334365
44extracellular matrix assembly (GO:0085029)2.83718180
45negative regulation of complement activation (GO:0045916)2.82274356
46alpha-linolenic acid metabolic process (GO:0036109)2.81900956
47regulation of fatty acid beta-oxidation (GO:0031998)2.81894294
48axon extension involved in axon guidance (GO:0048846)2.81597502
49neuron projection extension involved in neuron projection guidance (GO:1902284)2.81597502
504-hydroxyproline metabolic process (GO:0019471)2.79737051
51stress fiber assembly (GO:0043149)2.79577035
52regulation of metalloenzyme activity (GO:0048552)2.78514771
53multicellular organismal catabolic process (GO:0044243)2.78467309
54multicellular organismal metabolic process (GO:0044236)2.77807316
55retina vasculature morphogenesis in camera-type eye (GO:0061299)2.76570416
56extracellular matrix disassembly (GO:0022617)2.76142330
57negative regulation of protein activation cascade (GO:2000258)2.75957211
58paraxial mesoderm development (GO:0048339)2.74836694
59renal filtration (GO:0097205)2.74204313
60positive regulation of p38MAPK cascade (GO:1900745)2.73304046
61epoxygenase P450 pathway (GO:0019373)2.72986355
62positive regulation of nuclease activity (GO:0032075)2.72816589
63planar cell polarity pathway involved in neural tube closure (GO:0090179)2.72462480
64cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.70681411
65positive regulation of glycogen biosynthetic process (GO:0045725)2.68345447
66insulin-like growth factor receptor signaling pathway (GO:0048009)2.68098696
67retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.67601019
68positive regulation of fatty acid oxidation (GO:0046321)2.65243611
69cell migration involved in heart development (GO:0060973)2.64448656
70wound healing, spreading of epidermal cells (GO:0035313)2.64264020
71regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.62486501
72dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.61973341
73regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.61922499
74regulation of transforming growth factor beta2 production (GO:0032909)2.61849616
75negative regulation of smooth muscle cell migration (GO:0014912)2.60822472
76growth hormone receptor signaling pathway (GO:0060396)2.58376551
77endoplasmic reticulum unfolded protein response (GO:0030968)2.57299285
78peptidyl-proline hydroxylation (GO:0019511)2.56029321
79protein hydroxylation (GO:0018126)2.55567315
80regulation of cardioblast differentiation (GO:0051890)2.53792105
81L-ascorbic acid metabolic process (GO:0019852)2.53721564
82regulation of apoptotic cell clearance (GO:2000425)2.53713926
83cell proliferation involved in kidney development (GO:0072111)2.51573458
84endothelial cell morphogenesis (GO:0001886)2.51256303
85fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.50738188
86mesenchymal-epithelial cell signaling (GO:0060638)2.50471896
87cellular response to growth hormone stimulus (GO:0071378)2.48867343
88epithelial cell differentiation involved in prostate gland development (GO:0060742)2.47728090
89extracellular matrix organization (GO:0030198)2.47616222
90hippo signaling (GO:0035329)2.47196594
91metanephric mesenchyme development (GO:0072075)2.47196150
92extracellular structure organization (GO:0043062)2.46558379
93positive regulation of collagen biosynthetic process (GO:0032967)2.46347174
94negative regulation of cartilage development (GO:0061037)2.45877370
95regulation of glucose import in response to insulin stimulus (GO:2001273)2.45672008
96cellular response to unfolded protein (GO:0034620)2.45227602
97regulation of p38MAPK cascade (GO:1900744)2.44541169
98blood vessel endothelial cell migration (GO:0043534)2.44178818
99cellular response to interferon-alpha (GO:0035457)2.43980770
100polarized epithelial cell differentiation (GO:0030859)2.43877703
101extracellular negative regulation of signal transduction (GO:1900116)2.42690964
102extracellular regulation of signal transduction (GO:1900115)2.42690964
103glomerular epithelial cell development (GO:0072310)2.41490362
104cell-substrate junction assembly (GO:0007044)2.41172075
105regulation of plasminogen activation (GO:0010755)2.40979861
106G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.40922005
107serine transport (GO:0032329)2.40655204
108glomerular filtration (GO:0003094)2.40491757
109protein localization to cell surface (GO:0034394)2.40100816
110ER-nucleus signaling pathway (GO:0006984)2.39913247
111adhesion of symbiont to host (GO:0044406)2.39517760
112regulation of collagen metabolic process (GO:0010712)2.38934793
113kidney mesenchyme development (GO:0072074)2.38598315
114cellular response to vitamin D (GO:0071305)2.37577234
115regulation of complement activation (GO:0030449)2.37539703
116regulation of nuclease activity (GO:0032069)2.37503493
117glomerular visceral epithelial cell development (GO:0072015)2.37382196
118regulation of fatty acid oxidation (GO:0046320)2.37073592
119negative regulation of cardiac muscle tissue growth (GO:0055022)2.35666631
120negative regulation of heart growth (GO:0061117)2.35666631
121cytoskeletal anchoring at plasma membrane (GO:0007016)2.35247654
122substrate adhesion-dependent cell spreading (GO:0034446)2.34205220
123nucleotide-sugar biosynthetic process (GO:0009226)2.31918584
124regulation of cholesterol storage (GO:0010885)2.31850664
125regulation of transforming growth factor beta1 production (GO:0032908)2.31356389
126positive regulation of collagen metabolic process (GO:0010714)2.31063983
127regulation of phospholipase A2 activity (GO:0032429)2.31043303
128regulation of protein activation cascade (GO:2000257)2.30681958
129cell proliferation involved in metanephros development (GO:0072203)2.30676033
130anterior/posterior axis specification, embryo (GO:0008595)2.29991542
131positive regulation of endothelial cell apoptotic process (GO:2000353)2.29222635
132positive regulation of osteoblast proliferation (GO:0033690)2.29011533
133fibrinolysis (GO:0042730)2.28931976
134chondrocyte development (GO:0002063)2.28926533
135lysine metabolic process (GO:0006553)2.28624374
136lysine catabolic process (GO:0006554)2.28624374
137negative regulation of cell size (GO:0045792)2.28168689
138surfactant homeostasis (GO:0043129)2.27170749
139negative regulation of chondrocyte differentiation (GO:0032331)2.26005867
140protein carboxylation (GO:0018214)2.25287614
141peptidyl-glutamic acid carboxylation (GO:0017187)2.25287614
142endothelial cell chemotaxis (GO:0035767)2.24901915
143positive regulation of extracellular matrix organization (GO:1903055)2.24434015
144cellular response to nutrient (GO:0031670)2.23905061
145branching involved in salivary gland morphogenesis (GO:0060445)2.22993255
146cellular response to topologically incorrect protein (GO:0035967)2.22540406
147valine metabolic process (GO:0006573)2.21809816
148positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.21301466
149positive regulation of glycogen metabolic process (GO:0070875)2.20365081
150regulation of membrane protein ectodomain proteolysis (GO:0051043)2.19841709
151regulation of cholesterol homeostasis (GO:2000188)2.18697916
152regulation of tight junction assembly (GO:2000810)2.18654748
153adherens junction assembly (GO:0034333)2.18057839
154sulfur amino acid catabolic process (GO:0000098)2.17977712
155virion attachment to host cell (GO:0019062)2.16988959
156adhesion of symbiont to host cell (GO:0044650)2.16988959

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.48871084
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.13850129
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.09255482
4CLOCK_20551151_ChIP-Seq_293T_Human3.77948529
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.74882059
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.33334087
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.87690365
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.49651971
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30577742
10* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.30091335
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.29092392
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.26971921
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.26841593
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.20762715
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.05894614
16* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.98789409
17* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96760576
18ZNF263_19887448_ChIP-Seq_K562_Human1.89848633
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89060520
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85974202
21CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.84536903
22EP300_21415370_ChIP-Seq_HL-1_Mouse1.69789014
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69681672
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.69586354
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.69586354
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.69586354
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68993544
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.64883212
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.61859478
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.61636452
31TCF3_18692474_ChIP-Seq_MEFs_Mouse1.61027489
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59882083
33* CJUN_26792858_Chip-Seq_BT549_Human1.59525190
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59176737
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56161014
36* TBX20_22080862_ChIP-Seq_HEART_Mouse1.54882783
37* TBX20_22328084_ChIP-Seq_HEART_Mouse1.54882783
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.53008784
39P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50998743
40* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.50419270
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49708422
42RACK7_27058665_Chip-Seq_MCF-7_Human1.44463858
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43896869
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.43152804
45* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.42865158
46EOMES_21245162_ChIP-Seq_HESCs_Human1.42757578
47TP53_18474530_ChIP-ChIP_U2OS_Human1.39685398
48* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38256336
49LXR_22292898_ChIP-Seq_THP-1_Human1.37797161
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37654591
51* SOX2_20726797_ChIP-Seq_SW620_Human1.35084655
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34934442
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34823451
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32612800
55* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32591535
56ATF3_27146783_Chip-Seq_COLON_Human1.32186347
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32177750
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32177750
59EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.30232504
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.29463702
61AR_21909140_ChIP-Seq_LNCAP_Human1.28978912
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28856855
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28676709
64FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.28203827
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27457569
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26099965
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.26066217
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25479395
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25080058
70* GATA2_21666600_ChIP-Seq_HMVEC_Human1.24513915
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23753622
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22799781
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22662258
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22590796
75SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21025611
76SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21025611
77* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20272653
78ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16568078
79BRD4_25478319_ChIP-Seq_HGPS_Human1.15809384
80KDM2B_26808549_Chip-Seq_K562_Human1.13990227
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12350057
82GATA1_22025678_ChIP-Seq_K562_Human1.12236285
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.12019589
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11935102
85FOXA2_19822575_ChIP-Seq_HepG2_Human1.09975410
86RUNX1_27514584_Chip-Seq_MCF-7_Human1.09939595
87* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09292238
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08458337
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08398418
90UBF1/2_26484160_Chip-Seq_HMECs_Human1.08250043
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07829985
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07718633
93TCF4_18268006_ChIP-ChIP_LS174T_Human1.07572273
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06247261
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06222411
96P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05196270
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03782657
98KDM2B_26808549_Chip-Seq_DND41_Human1.03368736
99* SOX17_20123909_ChIP-Seq_XEN_Mouse1.03271103
100* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02928933
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02730968
102* SA1_22415368_ChIP-Seq_MEFs_Mouse1.02206866
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01805772
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00577138
105* CDX2_20551321_ChIP-Seq_CACO-2_Human1.00576263
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00133946
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99059976
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98879973
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96944360
110* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96662555
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94943238
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93455890
113* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92443955
114SMAD3_21741376_ChIP-Seq_HESCs_Human0.92289556
115MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91533925
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90764552
117* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.90704408
118GATA4_25053715_ChIP-Seq_YYC3_Human0.90047090
119CREB1_26743006_Chip-Seq_LNCaP_Human0.89943504
120* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89378830
121WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89318509
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89243872
123PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88872588
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.88509212
125* TP53_20018659_ChIP-ChIP_R1E_Mouse0.88412817
126NANOG_18692474_ChIP-Seq_MEFs_Mouse0.88357041
127FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88069856
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87830851
129GATA3_24758297_ChIP-Seq_MCF-7_Human0.86883668
130KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86855444
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86149611
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85989236
133EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85907249
134TP63_23658742_ChIP-Seq_EP156T_Human0.85850485
135TP53_22127205_ChIP-Seq_IMR90_Human0.85428171
136* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82394976

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.73360351
2MP0003705_abnormal_hypodermis_morpholog4.03095700
3MP0005275_abnormal_skin_tensile3.90475416
4MP0004272_abnormal_basement_membrane2.91171543
5MP0005503_abnormal_tendon_morphology2.85216992
6MP0003941_abnormal_skin_development2.78548768
7MP0001958_emphysema2.52322764
8MP0003279_aneurysm2.36402792
9MP0006054_spinal_hemorrhage2.28519889
10MP0003566_abnormal_cell_adhesion2.10598880
11MP0005623_abnormal_meninges_morphology2.08187009
12MP0003300_gastrointestinal_ulcer2.06660244
13MP0009384_cardiac_valve_regurgitation2.03624341
14MP0010234_abnormal_vibrissa_follicle1.96792081
15MP0010368_abnormal_lymphatic_system1.89684171
16MP0000013_abnormal_adipose_tissue1.70719989
17MP0004084_abnormal_cardiac_muscle1.69809901
18MP0004130_abnormal_muscle_cell1.68306430
19MP0002896_abnormal_bone_mineralization1.66198128
20MP0003950_abnormal_plasma_membrane1.56530160
21MP0002796_impaired_skin_barrier1.55849818
22MP0003283_abnormal_digestive_organ1.52612892
23MP0004185_abnormal_adipocyte_glucose1.51128070
24MP0000751_myopathy1.50656457
25MP0002060_abnormal_skin_morphology1.49185366
26MP0008004_abnormal_stomach_pH1.45983972
27MP0000762_abnormal_tongue_morphology1.44850002
28MP0005058_abnormal_lysosome_morphology1.44698157
29MP0005023_abnormal_wound_healing1.44099861
30MP0000733_abnormal_muscle_development1.44080078
31MP0002295_abnormal_pulmonary_circulatio1.43024836
32MP0009780_abnormal_chondrocyte_physiolo1.41130392
33MP0004782_abnormal_surfactant_physiolog1.41066144
34MP0001879_abnormal_lymphatic_vessel1.40626614
35MP0002877_abnormal_melanocyte_morpholog1.37833215
36MP0005666_abnormal_adipose_tissue1.32037866
37MP0005508_abnormal_skeleton_morphology1.31914084
38MP0003091_abnormal_cell_migration1.30617623
39MP0010352_gastrointestinal_tract_polyps1.30379735
40MP0005257_abnormal_intraocular_pressure1.30008856
41MP0000534_abnormal_ureter_morphology1.25645062
42MP0000750_abnormal_muscle_regeneration1.25230693
43MP0002139_abnormal_hepatobiliary_system1.23894350
44MP0000537_abnormal_urethra_morphology1.23571476
45MP0003252_abnormal_bile_duct1.23442729
46MP0001849_ear_inflammation1.20276996
47MP0003045_fibrosis1.19854282
48MP0002837_dystrophic_cardiac_calcinosis1.18575234
49MP0003186_abnormal_redox_activity1.18247271
50MP0009840_abnormal_foam_cell1.14157591
51MP0005375_adipose_tissue_phenotype1.14002221
52MP0002108_abnormal_muscle_morphology1.13986505
53MP0000767_abnormal_smooth_muscle1.13931600
54MP0009053_abnormal_anal_canal1.13887264
55MP0003191_abnormal_cellular_cholesterol1.13685881
56MP0002254_reproductive_system_inflammat1.12782245
57MP0002168_other_aberrant_phenotype1.12252851
58MP0004036_abnormal_muscle_relaxation1.12212163
59MP0001299_abnormal_eye_distance/1.10789520
60MP0004087_abnormal_muscle_fiber1.10491691
61MP0000462_abnormal_digestive_system1.10012439
62MP0000003_abnormal_adipose_tissue1.06859614
63MP0001243_abnormal_dermal_layer1.06318600
64MP0005167_abnormal_blood-brain_barrier1.06059918
65MP0005164_abnormal_response_to1.05898971
66MP0004858_abnormal_nervous_system1.04890474
67MP0005670_abnormal_white_adipose1.03752974
68MP0002909_abnormal_adrenal_gland0.98404492
69MP0005076_abnormal_cell_differentiation0.98029749
70MP0003942_abnormal_urinary_system0.97816329
71MP0000467_abnormal_esophagus_morphology0.97426232
72MP0005595_abnormal_vascular_smooth0.96398545
73MP0010329_abnormal_lipoprotein_level0.96316386
74MP0005360_urolithiasis0.95234843
75MP0000579_abnormal_nail_morphology0.92984299
76MP0001756_abnormal_urination0.92534887
77MP0005197_abnormal_uvea_morphology0.92502075
78MP0006138_congestive_heart_failure0.91427445
79MP0003195_calcinosis0.90929473
80MP0002233_abnormal_nose_morphology0.90462855
81MP0002234_abnormal_pharynx_morphology0.89325056
82MP0000428_abnormal_craniofacial_morphol0.89284914
83MP0002115_abnormal_skeleton_extremities0.88880668
84MP0000747_muscle_weakness0.88866547
85MP0005501_abnormal_skin_physiology0.88372389
86MP0010630_abnormal_cardiac_muscle0.87936639
87MP0009643_abnormal_urine_homeostasis0.87043124
88MP0004264_abnormal_extraembryonic_tissu0.86826573
89MP0000163_abnormal_cartilage_morphology0.86318391
90MP0010386_abnormal_urinary_bladder0.86121292
91MP0004233_abnormal_muscle_weight0.85252980
92MP0002128_abnormal_blood_circulation0.84577996
93MP0010030_abnormal_orbit_morphology0.84072416
94MP0000343_altered_response_to0.83321466
95MP0003115_abnormal_respiratory_system0.83264391
96MP0005365_abnormal_bile_salt0.81943970
97MP0005330_cardiomyopathy0.81893406
98MP0001666_abnormal_nutrient_absorption0.81498276
99MP0002282_abnormal_trachea_morphology0.81233117
100MP0009250_abnormal_appendicular_skeleto0.80777980
101MP0003385_abnormal_body_wall0.79987047
102MP0005388_respiratory_system_phenotype0.79298805
103MP0002133_abnormal_respiratory_system0.79298805
104MP0001542_abnormal_bone_strength0.76667231
105MP0005165_increased_susceptibility_to0.75907553
106MP0002998_abnormal_bone_remodeling0.75855053
107MP0005367_renal/urinary_system_phenotyp0.75682444
108MP0000516_abnormal_urinary_system0.75682444
109MP0001614_abnormal_blood_vessel0.75296951
110MP0005390_skeleton_phenotype0.75238346
111MP0008961_abnormal_basal_metabolism0.75225660
112MP0001533_abnormal_skeleton_physiology0.74246074
113MP0005385_cardiovascular_system_phenoty0.73478607
114MP0001544_abnormal_cardiovascular_syste0.73478607
115MP0004019_abnormal_vitamin_homeostasis0.73280706
116MP0005220_abnormal_exocrine_pancreas0.72827716
117MP0005193_abnormal_anterior_eye0.71988084
118MP0001915_intracranial_hemorrhage0.71365958
119MP0003828_pulmonary_edema0.71057363
120MP0002269_muscular_atrophy0.70923176
121MP0000749_muscle_degeneration0.70920352
122MP0010771_integument_phenotype0.70754825
123MP0000759_abnormal_skeletal_muscle0.70676745
124MP0000432_abnormal_head_morphology0.70626375
125MP0001881_abnormal_mammary_gland0.70125643
126MP0001270_distended_abdomen0.69440662
127MP0005085_abnormal_gallbladder_physiolo0.69380062
128MP0003868_abnormal_feces_composition0.69040608
129MP0005620_abnormal_muscle_contractility0.68869347
130MP0005332_abnormal_amino_acid0.68824645
131MP0001216_abnormal_epidermal_layer0.68629758
132MP0002113_abnormal_skeleton_development0.65772908
133MP0003755_abnormal_palate_morphology0.65633585
134MP0004883_abnormal_blood_vessel0.64899635
135MP0003453_abnormal_keratinocyte_physiol0.63620709
136MP0005409_darkened_coat_color0.62880678
137MP0003795_abnormal_bone_structure0.62252338
138MP0000627_abnormal_mammary_gland0.59513271
139MP0002697_abnormal_eye_size0.57787270
140MP0002925_abnormal_cardiovascular_devel0.57642435
141MP0002111_abnormal_tail_morphology0.57501027

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.66912760
2Premature rupture of membranes (HP:0001788)4.91983088
3Ankle contracture (HP:0006466)4.15013985
4Cerebral aneurysm (HP:0004944)4.04595870
5Broad metatarsal (HP:0001783)3.97532520
6Aortic dissection (HP:0002647)3.90106461
7Shallow orbits (HP:0000586)3.81395807
8Aortic aneurysm (HP:0004942)3.72236099
9Atrophic scars (HP:0001075)3.40664893
10Type 1 muscle fiber predominance (HP:0003803)3.35048770
11Cervical subluxation (HP:0003308)3.24669756
12Systemic lupus erythematosus (HP:0002725)2.96154464
13Mitral valve prolapse (HP:0001634)2.91125808
14Bladder diverticulum (HP:0000015)2.88213957
15Peritonitis (HP:0002586)2.86806587
16Increased connective tissue (HP:0009025)2.81680886
17Aneurysm (HP:0002617)2.79482310
18Dilatation of the ascending aorta (HP:0005111)2.73530913
19Soft skin (HP:0000977)2.69312113
20Abnormal delivery (HP:0001787)2.61819501
21Vascular tortuosity (HP:0004948)2.57137578
22Spinal rigidity (HP:0003306)2.55321338
23Increased variability in muscle fiber diameter (HP:0003557)2.54943847
24Fragile skin (HP:0001030)2.51339883
25Right ventricular cardiomyopathy (HP:0011663)2.50466165
26Cardiovascular calcification (HP:0011915)2.45925108
27Arterial tortuosity (HP:0005116)2.42645617
28Blue sclerae (HP:0000592)2.42642550
29Lymphangioma (HP:0100764)2.42226032
30Follicular hyperkeratosis (HP:0007502)2.42206688
31Abnormality of complement system (HP:0005339)2.39972202
32Mitral stenosis (HP:0001718)2.38981028
33Mildly elevated creatine phosphokinase (HP:0008180)2.38815407
34Abnormality of carpal bone ossification (HP:0006257)2.37511680
35Hematochezia (HP:0002573)2.37213308
36Abnormality of dentin (HP:0010299)2.33914796
37Long toe (HP:0010511)2.31404885
38Coronal craniosynostosis (HP:0004440)2.31144695
39Deep venous thrombosis (HP:0002625)2.29739801
40Striae distensae (HP:0001065)2.27939979
41Glomerulonephritis (HP:0000099)2.27339435
42Wormian bones (HP:0002645)2.24668489
43Abnormality of skeletal muscle fiber size (HP:0012084)2.24463913
44Enlarged penis (HP:0000040)2.19294606
45Short nail (HP:0001799)2.19173400
46Asymmetric septal hypertrophy (HP:0001670)2.17399288
47Vertebral compression fractures (HP:0002953)2.16582884
48Buphthalmos (HP:0000557)2.15849140
49Neonatal short-limb short stature (HP:0008921)2.15803799
50Osteolytic defects of the hand bones (HP:0009699)2.15744604
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.15744604
52Genu recurvatum (HP:0002816)2.14373403
53Hyperextensible skin (HP:0000974)2.14058769
54Hyporeflexia of lower limbs (HP:0002600)2.14007582
55Turricephaly (HP:0000262)2.13702174
56Back pain (HP:0003418)2.11780632
57Ulnar bowing (HP:0003031)2.10424837
58Distal upper limb amyotrophy (HP:0007149)2.09708836
59Upper limb amyotrophy (HP:0009129)2.09708836
60Thin bony cortex (HP:0002753)2.08712129
61Pterygium (HP:0001059)2.08655942
62Vascular calcification (HP:0004934)2.06918599
63Breech presentation (HP:0001623)2.06824300
64Camptodactyly of toe (HP:0001836)2.05280493
65Nuclear cataract (HP:0100018)2.04838342
66Abnormality of glycolipid metabolism (HP:0010969)2.04195274
67Abnormality of liposaccharide metabolism (HP:0010968)2.04195274
68Abnormality of glycosphingolipid metabolism (HP:0004343)2.04195274
69Difficulty running (HP:0009046)2.03404194
70Round ear (HP:0100830)2.02330020
71Scapular winging (HP:0003691)2.01309474
72Exercise-induced muscle cramps (HP:0003710)2.00198709
73Joint laxity (HP:0001388)1.98783861
74Urinary glycosaminoglycan excretion (HP:0003541)1.98543755
75Mucopolysacchariduria (HP:0008155)1.98543755
76Difficulty climbing stairs (HP:0003551)1.97889288
77Mesangial abnormality (HP:0001966)1.97428521
78Muscle fiber splitting (HP:0003555)1.96335978
79Spondylolisthesis (HP:0003302)1.95656922
80Intrahepatic cholestasis (HP:0001406)1.94562299
81Deviation of the hallux (HP:0010051)1.93858266
82Hand muscle atrophy (HP:0009130)1.93730412
83Wrist flexion contracture (HP:0001239)1.92465504
84Abnormal ossification of hand bones (HP:0005921)1.92434177
85Aplasia involving bones of the extremities (HP:0009825)1.89246536
86Aplasia involving bones of the upper limbs (HP:0009823)1.89246536
87Aplasia of the phalanges of the hand (HP:0009802)1.89246536
88Ectopia lentis (HP:0001083)1.89219830
89Ovoid vertebral bodies (HP:0003300)1.89036970
90Abnormality of molar morphology (HP:0011070)1.88962275
91Abnormality of molar (HP:0011077)1.88962275
92Dysostosis multiplex (HP:0000943)1.88282182
93Elbow flexion contracture (HP:0002987)1.87104933
94Rectal prolapse (HP:0002035)1.87079261
95Pulmonary artery stenosis (HP:0004415)1.86742721
96Complement deficiency (HP:0004431)1.86408858
97Bowel diverticulosis (HP:0005222)1.86030594
98Natal tooth (HP:0000695)1.85615636
99Hallux valgus (HP:0001822)1.85182046
100Bronchomalacia (HP:0002780)1.84280859
101Slender build (HP:0001533)1.83520504
102Abnormal hand bone ossification (HP:0010660)1.83303671
103Cupped ribs (HP:0000887)1.81945476
104Venous abnormality (HP:0002624)1.81115850
105Knee flexion contracture (HP:0006380)1.80895853
106Coxa vara (HP:0002812)1.79914484
107Bowing of the arm (HP:0006488)1.79799072
108Bowed forearm bones (HP:0003956)1.79799072
109Abnormal cartilage morphology (HP:0002763)1.79628106
110Radial bowing (HP:0002986)1.79622275
111Hypoglycemic coma (HP:0001325)1.79119051
112Biconcave vertebral bodies (HP:0004586)1.79013682
113Tetraparesis (HP:0002273)1.78580571
114Subacute progressive viral hepatitis (HP:0006572)1.78144938
115Hydroxyprolinuria (HP:0003080)1.77935459
116Abnormality of proline metabolism (HP:0010907)1.77935459
117Wide anterior fontanel (HP:0000260)1.77335653
118Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77235454
119Vertebral hypoplasia (HP:0008417)1.77235454
120Delayed cranial suture closure (HP:0000270)1.77103382
121Achilles tendon contracture (HP:0001771)1.76799211
122Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75751095
123Abnormality of polysaccharide metabolism (HP:0011012)1.75751095
124Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75751095
125Abnormality of the acetabulum (HP:0003170)1.75098936
126Focal segmental glomerulosclerosis (HP:0000097)1.74983679
127Abnormality of the Achilles tendon (HP:0005109)1.74783777
128Aortic valve stenosis (HP:0001650)1.73844743
129Polycythemia (HP:0001901)1.73714387
130Vacuolated lymphocytes (HP:0001922)1.73572068
131Osteopenia (HP:0000938)1.73223585
132Increased cerebral lipofuscin (HP:0011813)1.72553733
133Alopecia of scalp (HP:0002293)1.71760756
134Fragile nails (HP:0001808)1.71512737
135Myoglobinuria (HP:0002913)1.71499520
136Abnormality of the umbilical cord (HP:0010881)1.71344147
137Abnormal umbilical cord blood vessels (HP:0011403)1.70574167
138Single umbilical artery (HP:0001195)1.70574167
139Abnormality of the fetal cardiovascular system (HP:0010948)1.70574167
140Joint stiffness (HP:0001387)1.70524032
141Onycholysis (HP:0001806)1.69378885
142Overgrowth (HP:0001548)1.69322199
143Congenital glaucoma (HP:0001087)1.69221038
144Thin skin (HP:0000963)1.68475242
145Skin nodule (HP:0200036)1.68277187
146Generalized amyotrophy (HP:0003700)1.68073012
147Nephritis (HP:0000123)1.67109019
148Osteoarthritis (HP:0002758)1.66620039
149Beaking of vertebral bodies (HP:0004568)1.66347182
150Axonal loss (HP:0003447)1.65154561
151Inguinal hernia (HP:0000023)1.64173270
152Abnormality of the dental pulp (HP:0006479)1.63481595
153Abnormality of permanent molar morphology (HP:0011071)1.62308545
154Abnormality of the dental root (HP:0006486)1.62308545
155Taurodontia (HP:0000679)1.62308545
156Abnormality of monocarboxylic acid metabolism (HP:0010996)1.59749921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.03517510
2TTN3.24332103
3ERN13.20909525
4PKN23.13191389
5DDR23.08450323
6PDGFRA2.87480795
7SIK12.70657281
8RIPK12.53824700
9LATS12.53108145
10PBK2.26701453
11TGFBR22.21146245
12PTK62.08306070
13LMTK21.95305574
14MST41.86891864
15EPHB21.83203928
16MAP3K121.81847158
17FER1.77869754
18LRRK21.76729849
19ERBB41.61586934
20STK38L1.57021258
21PAK41.49051242
22TIE11.48280521
23EEF2K1.46799591
24SCYL21.46084171
25FGFR41.46026534
26STK241.45670189
27PTK21.40130396
28LATS21.36473310
29EPHB11.32626033
30BCKDK1.29008546
31FRK1.28941213
32VRK21.28117156
33PAK21.27553489
34EPHA31.26891514
35MET1.24821125
36PIM21.21255348
37CAMK1D1.20673095
38MAP3K21.18347149
39NEK91.17359689
40PRKD31.14751428
41BMPR1B1.14395271
42FLT31.14030748
43KSR21.12687572
44MYLK1.12225608
45PDK41.10990923
46PDK31.10990923
47STK161.10815581
48NTRK11.09491551
49EIF2AK11.08685094
50RET1.08123524
51BMX1.07924108
52ABL21.06342541
53ARAF1.06152502
54NME21.05354636
55DMPK1.04106284
56PAK31.02160096
57MST1R1.01395833
58PDGFRB0.99556888
59BCR0.96493901
60GRK10.95835754
61MAPKAPK30.94802715
62TESK10.94513953
63FGFR20.94186774
64ILK0.91420334
65PHKG10.90120475
66PHKG20.90120475
67PDK20.89908794
68MAP2K10.86743714
69MAP3K100.84267099
70JAK10.84002313
71FGFR30.83280657
72FGFR10.82566699
73CAMK1G0.81924298
74WNK40.80073221
75EIF2AK30.79718313
76PRKCE0.79555434
77STK30.79532046
78CDK60.77586956
79MTOR0.77527142
80MAP3K30.76750534
81DYRK1B0.76155902
82NEK10.74205759
83PIK3CG0.74147475
84CAMKK10.72774702
85ROCK10.72015523
86KIT0.71670591
87KDR0.71257363
88TGFBR10.71226580
89EPHA20.70686631
90MAPK70.70038031
91PRKD10.68854529
92CDK80.66700263
93PRKCH0.65923979
94TRPM70.65709729
95ACVR1B0.64636231
96CDK90.61907281
97ERBB30.61891431
98CAMKK20.61713440
99DAPK30.61112388
100MOS0.58628842
101MAP2K30.58436453
102PTK2B0.57834045
103INSRR0.56837723
104PIK3CA0.54965708
105PLK20.54782814
106LIMK10.54413633
107JAK20.50955214
108GSK3A0.50574223
109MAP3K70.50534376
110BRSK20.49513436
111CAMK2D0.48234076
112NUAK10.47019658
113STK380.46827526
114GRK70.45531230
115ICK0.44609690
116MAP3K10.43685204
117TBK10.42940770
118CDC42BPA0.42627544
119MAPK150.42493983
120CAMK2G0.42002293
121TYRO30.41748981
122CSNK1G10.41562344
123MKNK10.41510122
124ERBB20.40523295
125TRIM280.39459075
126SRC0.38458382
127PAK60.37682239
128IGF1R0.37057155
129TYK20.36491549
130RPS6KA40.36362952
131PRKG20.36240134
132MAP2K20.36211775
133STK100.36178168
134MAP3K60.36160927
135AKT30.35941443
136ROCK20.35893439
137PDPK10.34744279
138ADRBK10.33039835
139PLK30.30768344
140TTK0.27981725
141SIK30.27702342

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.67995439
2ECM-receptor interaction_Homo sapiens_hsa045122.47771837
3Fatty acid elongation_Homo sapiens_hsa000622.47765292
4Fatty acid degradation_Homo sapiens_hsa000712.12289280
5Protein export_Homo sapiens_hsa030602.10610629
6Focal adhesion_Homo sapiens_hsa045101.97749667
7Glutathione metabolism_Homo sapiens_hsa004801.86490520
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.83125755
9Fatty acid metabolism_Homo sapiens_hsa012121.75105035
10PPAR signaling pathway_Homo sapiens_hsa033201.63953967
11Protein digestion and absorption_Homo sapiens_hsa049741.63621274
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62235189
13Steroid biosynthesis_Homo sapiens_hsa001001.61726254
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60087786
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52686508
16Amoebiasis_Homo sapiens_hsa051461.50597189
17Proteoglycans in cancer_Homo sapiens_hsa052051.48465297
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47154562
19Histidine metabolism_Homo sapiens_hsa003401.46063952
20Propanoate metabolism_Homo sapiens_hsa006401.43822507
21Caffeine metabolism_Homo sapiens_hsa002321.40916726
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.38246450
23Vibrio cholerae infection_Homo sapiens_hsa051101.37978709
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36510036
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.35825658
26Adherens junction_Homo sapiens_hsa045201.34677379
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32776820
28Folate biosynthesis_Homo sapiens_hsa007901.32189177
29Complement and coagulation cascades_Homo sapiens_hsa046101.30062519
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29673603
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.29669785
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29613317
33Vitamin digestion and absorption_Homo sapiens_hsa049771.27304465
34* Lysosome_Homo sapiens_hsa041421.24574087
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24061884
36Insulin resistance_Homo sapiens_hsa049311.22663534
37Phenylalanine metabolism_Homo sapiens_hsa003601.21807451
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21368158
39Galactose metabolism_Homo sapiens_hsa000521.21291724
40Bladder cancer_Homo sapiens_hsa052191.21008332
41Proteasome_Homo sapiens_hsa030501.20583613
42Dilated cardiomyopathy_Homo sapiens_hsa054141.19753327
43Tryptophan metabolism_Homo sapiens_hsa003801.18434760
44Mineral absorption_Homo sapiens_hsa049781.17620810
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.16054299
46Bile secretion_Homo sapiens_hsa049761.14838627
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.14565543
48Small cell lung cancer_Homo sapiens_hsa052221.14076026
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13811728
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12511664
51Retinol metabolism_Homo sapiens_hsa008301.09650695
52Arginine biosynthesis_Homo sapiens_hsa002201.09089292
53Tyrosine metabolism_Homo sapiens_hsa003501.08889687
54Adipocytokine signaling pathway_Homo sapiens_hsa049201.08647848
55Primary bile acid biosynthesis_Homo sapiens_hsa001201.06968815
56Sphingolipid metabolism_Homo sapiens_hsa006001.05989325
57Fatty acid biosynthesis_Homo sapiens_hsa000611.04472500
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99477958
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97665179
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96679862
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91986656
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90940394
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.90606462
64Chronic myeloid leukemia_Homo sapiens_hsa052200.89389628
65Hippo signaling pathway_Homo sapiens_hsa043900.87726089
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.87607272
67Arginine and proline metabolism_Homo sapiens_hsa003300.85805686
68Peroxisome_Homo sapiens_hsa041460.85694423
69mTOR signaling pathway_Homo sapiens_hsa041500.84436060
70Starch and sucrose metabolism_Homo sapiens_hsa005000.83981650
71Sulfur metabolism_Homo sapiens_hsa009200.83054918
72Carbon metabolism_Homo sapiens_hsa012000.82231910
73Pyruvate metabolism_Homo sapiens_hsa006200.81617977
74AMPK signaling pathway_Homo sapiens_hsa041520.81196926
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80569249
76Staphylococcus aureus infection_Homo sapiens_hsa051500.80281475
77Pertussis_Homo sapiens_hsa051330.79081647
78Fat digestion and absorption_Homo sapiens_hsa049750.77919923
79Tight junction_Homo sapiens_hsa045300.77523457
80Insulin signaling pathway_Homo sapiens_hsa049100.75979550
81Prion diseases_Homo sapiens_hsa050200.75362223
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.74736461
83Thyroid hormone synthesis_Homo sapiens_hsa049180.74458265
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73171329
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73093885
86TGF-beta signaling pathway_Homo sapiens_hsa043500.72664312
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72533800
88Butanoate metabolism_Homo sapiens_hsa006500.72092907
89Pentose phosphate pathway_Homo sapiens_hsa000300.71484955
90Toxoplasmosis_Homo sapiens_hsa051450.70708909
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70708854
92Biosynthesis of amino acids_Homo sapiens_hsa012300.70108956
93Arachidonic acid metabolism_Homo sapiens_hsa005900.69733104
94Pancreatic cancer_Homo sapiens_hsa052120.69635531
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69460778
96Renin-angiotensin system_Homo sapiens_hsa046140.65330398
97Lysine degradation_Homo sapiens_hsa003100.64629762
98Selenocompound metabolism_Homo sapiens_hsa004500.63827632
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63616020
100Renal cell carcinoma_Homo sapiens_hsa052110.62946967
101Glioma_Homo sapiens_hsa052140.62937934
102Malaria_Homo sapiens_hsa051440.62235538
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62109087
104Other glycan degradation_Homo sapiens_hsa005110.62073786
105Glucagon signaling pathway_Homo sapiens_hsa049220.62022163
106Endometrial cancer_Homo sapiens_hsa052130.60907930
107Basal cell carcinoma_Homo sapiens_hsa052170.60382661
108Platelet activation_Homo sapiens_hsa046110.59717990
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59348236
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59164836
111Estrogen signaling pathway_Homo sapiens_hsa049150.57343170
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57137063
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.57073080
114beta-Alanine metabolism_Homo sapiens_hsa004100.54480923
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53811976
116Fructose and mannose metabolism_Homo sapiens_hsa000510.53540083
117Melanoma_Homo sapiens_hsa052180.53483572
118Viral myocarditis_Homo sapiens_hsa054160.51266339
119VEGF signaling pathway_Homo sapiens_hsa043700.51246559
120Chemical carcinogenesis_Homo sapiens_hsa052040.50077457
121Endocytosis_Homo sapiens_hsa041440.49549671
122Rap1 signaling pathway_Homo sapiens_hsa040150.49223598
123MicroRNAs in cancer_Homo sapiens_hsa052060.48688228
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48618199
125N-Glycan biosynthesis_Homo sapiens_hsa005100.48514054
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48209340
127Glycerolipid metabolism_Homo sapiens_hsa005610.48176601
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47810175
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47008784
130Prostate cancer_Homo sapiens_hsa052150.45964552
131Hedgehog signaling pathway_Homo sapiens_hsa043400.45396858
132Wnt signaling pathway_Homo sapiens_hsa043100.45378429
133Type II diabetes mellitus_Homo sapiens_hsa049300.44493029
134Thyroid cancer_Homo sapiens_hsa052160.43326139
135Metabolic pathways_Homo sapiens_hsa011000.43019454
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.42597042
137Phagosome_Homo sapiens_hsa041450.41727606
138Circadian rhythm_Homo sapiens_hsa047100.39933046
139Pathways in cancer_Homo sapiens_hsa052000.39754674

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