LAPTM4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal rod cell development (GO:0046548)5.95046322
2detection of light stimulus involved in sensory perception (GO:0050962)5.88819189
3detection of light stimulus involved in visual perception (GO:0050908)5.88819189
4rhodopsin mediated signaling pathway (GO:0016056)5.04882913
5regulation of rhodopsin mediated signaling pathway (GO:0022400)4.81690794
6response to pheromone (GO:0019236)4.80343574
7cellular potassium ion homeostasis (GO:0030007)4.65401758
8photoreceptor cell development (GO:0042461)4.37676744
9eye photoreceptor cell differentiation (GO:0001754)4.33315947
10photoreceptor cell differentiation (GO:0046530)4.33315947
11retinal cone cell development (GO:0046549)4.28663834
12establishment of integrated proviral latency (GO:0075713)4.24268957
13DNA unwinding involved in DNA replication (GO:0006268)4.18613645
14paraxial mesoderm development (GO:0048339)4.17752904
15photoreceptor cell maintenance (GO:0045494)4.15921031
16eye photoreceptor cell development (GO:0042462)4.11818619
17potassium ion homeostasis (GO:0055075)4.08320259
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.08299455
19regulation of female gonad development (GO:2000194)4.01924963
20nuclear pore complex assembly (GO:0051292)3.94929424
21heterochromatin organization (GO:0070828)3.76972645
22protein-chromophore linkage (GO:0018298)3.61252075
23nuclear pore organization (GO:0006999)3.59614937
24regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.59426687
25sodium ion export (GO:0071436)3.52096122
26protein complex localization (GO:0031503)3.50629866
27apical protein localization (GO:0045176)3.47685636
28pre-miRNA processing (GO:0031054)3.39972569
29regulation of gene silencing by RNA (GO:0060966)3.36597900
30regulation of posttranscriptional gene silencing (GO:0060147)3.36597900
31regulation of gene silencing by miRNA (GO:0060964)3.36597900
32mitotic chromosome condensation (GO:0007076)3.31949321
33notochord development (GO:0030903)3.30105345
34visual perception (GO:0007601)3.27509470
35regulation of cardioblast differentiation (GO:0051890)3.27484779
36detection of visible light (GO:0009584)3.27031122
37nonmotile primary cilium assembly (GO:0035058)3.26334698
38sensory perception of light stimulus (GO:0050953)3.26209769
39detection of light stimulus (GO:0009583)3.25694477
40chromatin remodeling at centromere (GO:0031055)3.25659706
41protein localization to kinetochore (GO:0034501)3.23604883
42regulation of translational fidelity (GO:0006450)3.23265287
43estrogen biosynthetic process (GO:0006703)3.22927561
44L-serine metabolic process (GO:0006563)3.22355047
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.20893739
46DNA strand elongation involved in DNA replication (GO:0006271)3.19748136
47CENP-A containing nucleosome assembly (GO:0034080)3.19401051
48synaptic vesicle exocytosis (GO:0016079)3.13431195
49formation of translation preinitiation complex (GO:0001731)3.12496159
50negative regulation of cytosolic calcium ion concentration (GO:0051481)3.12399368
51bundle of His cell to Purkinje myocyte communication (GO:0086069)3.10818695
52positive regulation of SMAD protein import into nucleus (GO:0060391)3.10012249
53mitotic metaphase plate congression (GO:0007080)3.08768446
54DNA strand elongation (GO:0022616)3.07785799
55piRNA metabolic process (GO:0034587)3.04255568
56phototransduction (GO:0007602)3.03175345
57cell migration involved in gastrulation (GO:0042074)2.99413082
58mitotic sister chromatid cohesion (GO:0007064)2.99067838
59GMP metabolic process (GO:0046037)2.98228102
60negative regulation of cell fate specification (GO:0009996)2.97021395
61protein localization to chromosome, centromeric region (GO:0071459)2.95572213
62regulation of cell fate specification (GO:0042659)2.95496867
63ribosomal small subunit assembly (GO:0000028)2.95489123
64phototransduction, visible light (GO:0007603)2.94482580
65innervation (GO:0060384)2.93366042
66potassium ion export (GO:0071435)2.92461001
67establishment of viral latency (GO:0019043)2.92254031
68cellular protein complex localization (GO:0034629)2.91975235
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91377101
70regulation of centriole replication (GO:0046599)2.85736851
71DNA replication checkpoint (GO:0000076)2.84187385
72cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.83569608
73gap junction assembly (GO:0016264)2.82563046
74membrane repolarization (GO:0086009)2.82485535
75positive regulation of sodium ion transmembrane transport (GO:1902307)2.81014427
76urinary tract smooth muscle contraction (GO:0014848)2.80809902
77DNA replication-independent nucleosome organization (GO:0034724)2.79565794
78DNA replication-independent nucleosome assembly (GO:0006336)2.79565794
79convergent extension (GO:0060026)2.78339985
80regulation of stem cell maintenance (GO:2000036)2.77809872
81IMP biosynthetic process (GO:0006188)2.76826847
82anterior/posterior axis specification, embryo (GO:0008595)2.76206079
83histone exchange (GO:0043486)2.74065796
84regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.73737706
85protein localization to synapse (GO:0035418)2.73269568
86positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.72472313
87relaxation of smooth muscle (GO:0044557)2.70935916
88telomere maintenance via semi-conservative replication (GO:0032201)2.70765432
89DNA replication initiation (GO:0006270)2.70547217
90pore complex assembly (GO:0046931)2.69405882
91regulation of transforming growth factor beta2 production (GO:0032909)2.68535783
92planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67596599
93ribosome assembly (GO:0042255)2.65794430
94ribosomal large subunit biogenesis (GO:0042273)2.64907603
95DNA replication-dependent nucleosome organization (GO:0034723)2.63509163
96DNA replication-dependent nucleosome assembly (GO:0006335)2.63509163
97IMP metabolic process (GO:0046040)2.63468069
98sister chromatid segregation (GO:0000819)2.62682158
99neuromuscular process controlling posture (GO:0050884)2.62554424
100mating behavior (GO:0007617)2.62534449
101retina development in camera-type eye (GO:0060041)2.59960300
102axon ensheathment in central nervous system (GO:0032291)2.59575378
103central nervous system myelination (GO:0022010)2.59575378
104detection of abiotic stimulus (GO:0009582)2.58914076
105primitive streak formation (GO:0090009)2.58886541
106detection of external stimulus (GO:0009581)2.58837441
107ATP-dependent chromatin remodeling (GO:0043044)2.58181291
108potassium ion import (GO:0010107)2.58173712
109asymmetric protein localization (GO:0008105)2.57891844
110chromatin assembly (GO:0031497)2.57736592
111histone arginine methylation (GO:0034969)2.57536233
112purine nucleobase biosynthetic process (GO:0009113)2.56921914
113regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.56257979
114regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.56257979
115ribosomal small subunit biogenesis (GO:0042274)2.55478209
116regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.54957043
117membrane repolarization during action potential (GO:0086011)2.54870812
118mitotic sister chromatid segregation (GO:0000070)2.53954775
119cell communication by electrical coupling (GO:0010644)2.53750650
120negative regulation of cell fate commitment (GO:0010454)2.52424191
121cellular sodium ion homeostasis (GO:0006883)2.52026561
122cellular response to light stimulus (GO:0071482)2.51926013
123righting reflex (GO:0060013)2.51577458
124regulation of helicase activity (GO:0051095)2.51215381
125maturation of SSU-rRNA (GO:0030490)2.50739039
126metaphase plate congression (GO:0051310)2.50327669
127positive regulation of potassium ion transport (GO:0043268)2.49845181
128regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.48695094
129establishment of apical/basal cell polarity (GO:0035089)2.48600222
130regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.47995570
131nucleobase biosynthetic process (GO:0046112)2.47039502
132positive regulation of potassium ion transmembrane transport (GO:1901381)2.45279731
133glutamate secretion (GO:0014047)2.44912545
134synaptic vesicle maturation (GO:0016188)2.44849458
135regulation of synaptic vesicle exocytosis (GO:2000300)2.43870833
136fatty acid elongation (GO:0030497)2.43773044
137DNA duplex unwinding (GO:0032508)2.43390849
138hyperosmotic salinity response (GO:0042538)2.43319980
139lung-associated mesenchyme development (GO:0060484)2.42984062
140gamma-aminobutyric acid signaling pathway (GO:0007214)2.42634303
141regulation of voltage-gated calcium channel activity (GO:1901385)2.42045048
142mitotic nuclear envelope disassembly (GO:0007077)2.40601977
143G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.40310479
144double-strand break repair via nonhomologous end joining (GO:0006303)2.40021940
145non-recombinational repair (GO:0000726)2.40021940
146regulation of neurotransmitter uptake (GO:0051580)2.39420394
147regulation of meiosis (GO:0040020)2.39351231
148DNA topological change (GO:0006265)2.39043783
149peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.38569730
150protein polyglutamylation (GO:0018095)2.38511249
151regulation of mitochondrial translation (GO:0070129)2.38487323
152nucleosome disassembly (GO:0006337)2.38264555
153protein-DNA complex disassembly (GO:0032986)2.38264555
154chromatin assembly or disassembly (GO:0006333)2.38140659
155regulation of RNA export from nucleus (GO:0046831)2.37165889
156regulation of short-term neuronal synaptic plasticity (GO:0048172)2.36018571
157regulation of membrane repolarization (GO:0060306)2.35627645
158regulation of cGMP metabolic process (GO:0030823)2.35549031
159DNA geometric change (GO:0032392)2.35469667
160positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.34596832
161peptidyl-arginine omega-N-methylation (GO:0035247)2.34487992
162regulation of SMAD protein import into nucleus (GO:0060390)2.33758116
163negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.33682777
164mitotic recombination (GO:0006312)2.33139860
165layer formation in cerebral cortex (GO:0021819)2.33030680
166regulation of mesoderm development (GO:2000380)2.32873575
167microtubule severing (GO:0051013)2.32717330
168glycerophospholipid catabolic process (GO:0046475)2.32456210
169proline biosynthetic process (GO:0006561)2.32451796
170ventricular cardiac muscle cell development (GO:0055015)2.31845602
171positive regulation of catenin import into nucleus (GO:0035413)2.31600669
172synaptic vesicle endocytosis (GO:0048488)2.31480970
173positive regulation of synapse maturation (GO:0090129)2.31136879
174positive regulation of guanylate cyclase activity (GO:0031284)2.30887834
175positive regulation of TOR signaling (GO:0032008)2.30322706
176regulation of histone H3-K9 methylation (GO:0051570)2.30300974
177folic acid-containing compound biosynthetic process (GO:0009396)2.29663951
178positive regulation of chromosome segregation (GO:0051984)2.29569438
179nodal signaling pathway (GO:0038092)2.29462542
180hippo signaling (GO:0035329)2.29326409
181regulation of phospholipid biosynthetic process (GO:0071071)2.28858630
182response to misfolded protein (GO:0051788)2.28706229
183regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.28382832
184translational termination (GO:0006415)2.28374392
185dorsal/ventral axis specification (GO:0009950)2.27752361
186regulation of acrosome reaction (GO:0060046)2.26824840
187membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.25489225
188negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.25183801
189positive regulation of cGMP biosynthetic process (GO:0030828)2.24378330
190regulation of autophagic vacuole assembly (GO:2000785)2.23087772
191striatum development (GO:0021756)2.21433753
192positive regulation of gastrulation (GO:2000543)2.20473983
193membrane hyperpolarization (GO:0060081)2.18041493
194CDP-diacylglycerol biosynthetic process (GO:0016024)2.17207752
195negative regulation of hormone biosynthetic process (GO:0032353)2.15581008
196negative regulation of hormone metabolic process (GO:0032351)2.15581008
197estrogen metabolic process (GO:0008210)2.15297231
198regulation of synaptic vesicle transport (GO:1902803)2.14395425
199CDP-diacylglycerol metabolic process (GO:0046341)2.14220949
200regulation of cGMP biosynthetic process (GO:0030826)2.12572316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.27703788
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.34796791
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.60375608
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03015162
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02874059
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89240145
7AR_21909140_ChIP-Seq_LNCAP_Human2.75507792
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72867243
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.69731799
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.69731799
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.69731799
12GBX2_23144817_ChIP-Seq_PC3_Human2.68731468
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66734724
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47318627
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33848162
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29039630
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28915377
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.28764091
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.25500535
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21000377
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19785629
22ZNF263_19887448_ChIP-Seq_K562_Human2.11403047
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09789623
24ZFX_18555785_ChIP-Seq_MESCs_Mouse2.08518271
25* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.05663233
26VDR_22108803_ChIP-Seq_LS180_Human2.04170282
27ESR1_15608294_ChIP-ChIP_MCF-7_Human2.02132082
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.96593161
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95298786
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95298786
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94698942
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91470214
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89929831
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87558282
35TCF3_18692474_ChIP-Seq_MEFs_Mouse1.87463525
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86196329
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86126951
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84909204
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84098370
40XRN2_22483619_ChIP-Seq_HELA_Human1.82092266
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.81637377
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.80711413
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.78215800
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.75293428
45* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73819082
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73164952
47NANOG_16153702_ChIP-ChIP_HESCs_Human1.71804457
48* EZH2_27294783_Chip-Seq_ESCs_Mouse1.70675830
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70590569
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68163553
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67714371
52* TTF2_22483619_ChIP-Seq_HELA_Human1.66694013
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.66245834
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63762693
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.63754453
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63032246
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60187084
58NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.58981941
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57572693
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.54370740
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.54125495
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53181131
63* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51075551
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48820392
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.47654860
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46485857
67AR_21572438_ChIP-Seq_LNCaP_Human1.45970967
68EZH2_22144423_ChIP-Seq_EOC_Human1.45501268
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45232307
70CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.43307082
71DCP1A_22483619_ChIP-Seq_HELA_Human1.42725706
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.42418345
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42365758
74SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.41703970
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41562255
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40945501
77NANOG_21062744_ChIP-ChIP_HESCs_Human1.40657870
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.40258029
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39537056
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38855470
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37840529
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36925084
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36566137
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34482243
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34012254
86* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.32583764
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31357553
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31212555
89ELK1_19687146_ChIP-ChIP_HELA_Human1.30926210
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30828272
91GABP_17652178_ChIP-ChIP_JURKAT_Human1.30500344
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.29942968
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28623455
94FUS_26573619_Chip-Seq_HEK293_Human1.27065309
95SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27056038
96REST_21632747_ChIP-Seq_MESCs_Mouse1.26459291
97EST1_17652178_ChIP-ChIP_JURKAT_Human1.25937586
98* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23979493
99SOX17_20123909_ChIP-Seq_XEN_Mouse1.22013228
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21514068
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21346627
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21271643
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20277781
104TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.20061842
105SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19233681
106RNF2_27304074_Chip-Seq_NSC_Mouse1.18717814
107TP63_19390658_ChIP-ChIP_HaCaT_Human1.18443328
108SMAD4_21799915_ChIP-Seq_A2780_Human1.18071009
109* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16029850
110* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15246154
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14780782
112* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14766247
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14749470
114STAT3_23295773_ChIP-Seq_U87_Human1.14699253
115CBX2_27304074_Chip-Seq_ESCs_Mouse1.14356318
116CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14326272
117REST_18959480_ChIP-ChIP_MESCs_Mouse1.14072452
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13685716
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13527983
120PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12710068
121WT1_19549856_ChIP-ChIP_CCG9911_Human1.12063842
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10978137
123* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08983351
124TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07826093
125CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07024828
126WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06808789
127EOMES_21245162_ChIP-Seq_HESCs_Human1.05262264
128SMAD3_21741376_ChIP-Seq_HESCs_Human1.04997202
129SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04802659
130* RING1B_27294783_Chip-Seq_ESCs_Mouse1.04576597
131P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03993896
132DROSHA_22980978_ChIP-Seq_HELA_Human1.02515046
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02145676
134POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01710657
135NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01211766
136RING1B_27294783_Chip-Seq_NPCs_Mouse1.01201404
137STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01067171
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00256633
139GABP_19822575_ChIP-Seq_HepG2_Human0.99750841
140CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99732394
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99402417
142FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99157235
143ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99082963
144* CLOCK_20551151_ChIP-Seq_293T_Human0.98972508
145ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98538622
146DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98006455
147SMAD4_21741376_ChIP-Seq_EPCs_Human0.97856259
148* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97808543
149SMAD3_21741376_ChIP-Seq_EPCs_Human0.97432881
150HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96789964
151OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96490359
152NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96056019
153BCAT_22108803_ChIP-Seq_LS180_Human0.95641774
154OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95555154
155NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.95027873
156HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95019022
157STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94839682
158P300_19829295_ChIP-Seq_ESCs_Human0.94796254
159SOX2_21211035_ChIP-Seq_LN229_Gbm0.93433492
160ISL1_27105846_Chip-Seq_CPCs_Mouse0.93281558
161GATA1_26923725_Chip-Seq_HPCs_Mouse0.92982355
162FOXP3_21729870_ChIP-Seq_TREG_Human0.92736410
163TP53_20018659_ChIP-ChIP_R1E_Mouse0.92501772
164DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91019993
165* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90299628
166NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89889439
167CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89628715
168* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89325800
169RARB_27405468_Chip-Seq_BRAIN_Mouse0.89185648
170* CHD1_26751641_Chip-Seq_LNCaP_Human0.87709529
171TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87636269
172* MYC_18940864_ChIP-ChIP_HL60_Human0.87496604
173ZNF274_21170338_ChIP-Seq_K562_Hela0.87442850
174PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87130201
175* AR_19668381_ChIP-Seq_PC3_Human0.86616120
176TAF15_26573619_Chip-Seq_HEK293_Human0.86529731
177KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86133618
178E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86079474
179EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86038620
180ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85712929
181IGF1R_20145208_ChIP-Seq_DFB_Human0.85382037
182GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84570155
183RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84324553
184TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83819471
185LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83496804
186ESR1_20079471_ChIP-ChIP_T-47D_Human0.82370948
187AR_25329375_ChIP-Seq_VCAP_Human0.82249687
188EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82120218
189FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81893967
190TET1_21490601_ChIP-Seq_MESCs_Mouse0.81647149
191TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81196073

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog4.71923786
2MP0006072_abnormal_retinal_apoptosis4.24789356
3MP0003011_delayed_dark_adaptation4.06487907
4MP0003950_abnormal_plasma_membrane3.28374559
5MP0005253_abnormal_eye_physiology3.26545094
6MP0003941_abnormal_skin_development3.12897403
7MP0004957_abnormal_blastocyst_morpholog2.85994550
8MP0003693_abnormal_embryo_hatching2.82875638
9MP0002653_abnormal_ependyma_morphology2.72820190
10MP0008932_abnormal_embryonic_tissue2.31343383
11MP0010094_abnormal_chromosome_stability2.27653034
12MP0003111_abnormal_nucleus_morphology2.26276736
13MP0005195_abnormal_posterior_eye2.06862598
14MP0000537_abnormal_urethra_morphology1.96532159
15MP0009672_abnormal_birth_weight1.94591030
16MP0004233_abnormal_muscle_weight1.92634308
17MP0002090_abnormal_vision1.92275066
18MP0003880_abnormal_central_pattern1.88146144
19MP0010386_abnormal_urinary_bladder1.87391000
20MP0001730_embryonic_growth_arrest1.86328045
21MP0003136_yellow_coat_color1.85687416
22MP0003077_abnormal_cell_cycle1.85555195
23MP0010030_abnormal_orbit_morphology1.83124093
24MP0001984_abnormal_olfaction1.81679650
25MP0001293_anophthalmia1.81483040
26MP0002638_abnormal_pupillary_reflex1.79644107
27MP0002254_reproductive_system_inflammat1.77515087
28MP0005380_embryogenesis_phenotype1.76480592
29MP0001672_abnormal_embryogenesis/_devel1.76480592
30MP0003567_abnormal_fetal_cardiomyocyte1.74337806
31MP0002697_abnormal_eye_size1.74156850
32MP0002084_abnormal_developmental_patter1.74029528
33MP0002085_abnormal_embryonic_tissue1.61378555
34MP0003718_maternal_effect1.60217452
35MP0003984_embryonic_growth_retardation1.60073208
36MP0005391_vision/eye_phenotype1.58091765
37MP0001502_abnormal_circadian_rhythm1.54494684
38MP0002088_abnormal_embryonic_growth/wei1.54261945
39MP0004270_analgesia1.53776513
40MP0003646_muscle_fatigue1.51336344
41MP0004133_heterotaxia1.50579660
42MP0004043_abnormal_pH_regulation1.50512267
43MP0002229_neurodegeneration1.50420026
44MP0002752_abnormal_somatic_nervous1.48299971
45MP0004036_abnormal_muscle_relaxation1.48183524
46MP0001697_abnormal_embryo_size1.46411875
47MP0009697_abnormal_copulation1.43291757
48MP0004885_abnormal_endolymph1.42573668
49MP0008058_abnormal_DNA_repair1.41382189
50MP0000428_abnormal_craniofacial_morphol1.41323065
51MP0000534_abnormal_ureter_morphology1.37449147
52MP0003123_paternal_imprinting1.36486390
53MP0005623_abnormal_meninges_morphology1.35120986
54MP0004084_abnormal_cardiac_muscle1.33249958
55MP0002111_abnormal_tail_morphology1.32177425
56MP0010352_gastrointestinal_tract_polyps1.31583830
57MP0002080_prenatal_lethality1.31454801
58MP0002272_abnormal_nervous_system1.30442490
59MP0009379_abnormal_foot_pigmentation1.29067919
60MP0004145_abnormal_muscle_electrophysio1.28708867
61MP0000350_abnormal_cell_proliferation1.27851654
62MP0001286_abnormal_eye_development1.24405654
63MP0005451_abnormal_body_composition1.24344159
64MP0002234_abnormal_pharynx_morphology1.23893817
65MP0003283_abnormal_digestive_organ1.23690163
66MP0005423_abnormal_somatic_nervous1.22835474
67MP0000049_abnormal_middle_ear1.21227808
68MP0000579_abnormal_nail_morphology1.21109964
69MP0002086_abnormal_extraembryonic_tissu1.21074213
70MP0004859_abnormal_synaptic_plasticity1.20573508
71MP0010630_abnormal_cardiac_muscle1.19050160
72MP0004264_abnormal_extraembryonic_tissu1.18921875
73MP0003329_amyloid_beta_deposits1.18031132
74MP0002882_abnormal_neuron_morphology1.17744924
75MP0002734_abnormal_mechanical_nocicepti1.17198599
76MP0008057_abnormal_DNA_replication1.16504153
77MP0010234_abnormal_vibrissa_follicle1.16306946
78MP0004197_abnormal_fetal_growth/weight/1.12461025
79MP0004215_abnormal_myocardial_fiber1.12436353
80MP0001529_abnormal_vocalization1.12303783
81MP0003635_abnormal_synaptic_transmissio1.10005215
82MP0003315_abnormal_perineum_morphology1.09709851
83MP0009046_muscle_twitch1.09218383
84MP0001324_abnormal_eye_pigmentation1.07177778
85MP0009703_decreased_birth_body1.06914831
86MP0003935_abnormal_craniofacial_develop1.06812078
87MP0002938_white_spotting1.06321217
88MP0008789_abnormal_olfactory_epithelium1.06113085
89MP0008877_abnormal_DNA_methylation1.06051330
90MP0004185_abnormal_adipocyte_glucose1.03118938
91MP0002796_impaired_skin_barrier1.02741955
92MP0005499_abnormal_olfactory_system1.01404555
93MP0005394_taste/olfaction_phenotype1.01404555
94MP0000751_myopathy1.00721520
95MP0002092_abnormal_eye_morphology1.00337878
96MP0001849_ear_inflammation1.00181171
97MP0000631_abnormal_neuroendocrine_gland1.00011096
98MP0010368_abnormal_lymphatic_system0.99389331
99MP0003942_abnormal_urinary_system0.99297712
100MP0008007_abnormal_cellular_replicative0.98370627
101MP0004142_abnormal_muscle_tone0.97919078
102MP0003861_abnormal_nervous_system0.97795105
103MP0003937_abnormal_limbs/digits/tail_de0.97059876
104MP0000462_abnormal_digestive_system0.96873450
105MP0003705_abnormal_hypodermis_morpholog0.95744976
106MP0002184_abnormal_innervation0.94966913
107MP0003634_abnormal_glial_cell0.94574156
108MP0009053_abnormal_anal_canal0.93725788
109MP0003566_abnormal_cell_adhesion0.93641984
110MP0001661_extended_life_span0.93365303
111MP0005670_abnormal_white_adipose0.93254352
112MP0000955_abnormal_spinal_cord0.92850860
113MP0001299_abnormal_eye_distance/0.92206227
114MP0001486_abnormal_startle_reflex0.91736597
115MP0003755_abnormal_palate_morphology0.91418479
116MP0001485_abnormal_pinna_reflex0.89904580
117MP0000566_synostosis0.89790620
118MP0003121_genomic_imprinting0.88867492
119MP0002064_seizures0.87611824
120MP0005330_cardiomyopathy0.87047210
121MP0002909_abnormal_adrenal_gland0.86188618
122MP0002067_abnormal_sensory_capabilities0.85649398
123MP0008004_abnormal_stomach_pH0.85553953
124MP0000639_abnormal_adrenal_gland0.85081973
125MP0000013_abnormal_adipose_tissue0.83957039
126MP0005620_abnormal_muscle_contractility0.83503965
127MP0000432_abnormal_head_morphology0.83008102
128MP0009250_abnormal_appendicular_skeleto0.82827267
129MP0005248_abnormal_Harderian_gland0.82671825
130MP0001963_abnormal_hearing_physiology0.82391214
131MP0003787_abnormal_imprinting0.81534882
132MP0002102_abnormal_ear_morphology0.80163473
133MP0006292_abnormal_olfactory_placode0.79881449
134MP0002332_abnormal_exercise_endurance0.78261783
135MP0003122_maternal_imprinting0.77025764
136MP0005501_abnormal_skin_physiology0.77020706
137MP0006138_congestive_heart_failure0.76438513
138MP0003943_abnormal_hepatobiliary_system0.75983690
139MP0010307_abnormal_tumor_latency0.75396369
140MP0004087_abnormal_muscle_fiber0.75320730
141MP0008775_abnormal_heart_ventricle0.75198432
142MP0002925_abnormal_cardiovascular_devel0.74912268
143MP0001188_hyperpigmentation0.74904548
144MP0005646_abnormal_pituitary_gland0.74047828
145MP0005187_abnormal_penis_morphology0.73852451
146MP0003119_abnormal_digestive_system0.73824935
147MP0002063_abnormal_learning/memory/cond0.72454998
148MP0000762_abnormal_tongue_morphology0.72103571
149MP0003115_abnormal_respiratory_system0.70829563
150MP0009384_cardiac_valve_regurgitation0.70381176
151MP0001346_abnormal_lacrimal_gland0.70096777
152MP0002233_abnormal_nose_morphology0.69624356
153MP0002837_dystrophic_cardiac_calcinosis0.69375431
154MP0005257_abnormal_intraocular_pressure0.68925471
155MP0000266_abnormal_heart_morphology0.68735651
156MP0004272_abnormal_basement_membrane0.68695403
157MP0003879_abnormal_hair_cell0.68447170
158MP0002081_perinatal_lethality0.68365746
159MP0001905_abnormal_dopamine_level0.67646808
160MP0000778_abnormal_nervous_system0.67328523
161MP0005395_other_phenotype0.66392990
162MP0003890_abnormal_embryonic-extraembry0.66106630
163MP0003385_abnormal_body_wall0.66094355
164MP0000026_abnormal_inner_ear0.65471952
165MP0002249_abnormal_larynx_morphology0.64254629
166MP0002295_abnormal_pulmonary_circulatio0.64153527
167MP0000003_abnormal_adipose_tissue0.64047632
168MP0003699_abnormal_female_reproductive0.63449727

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)8.56788027
2Central scotoma (HP:0000603)5.72422703
3Bony spicule pigmentary retinopathy (HP:0007737)5.70410189
4Abnormality of macular pigmentation (HP:0008002)5.26234508
5Abnormal rod and cone electroretinograms (HP:0008323)5.13574692
6Scotoma (HP:0000575)4.60258061
7Chorioretinal atrophy (HP:0000533)4.44749447
8Abolished electroretinogram (ERG) (HP:0000550)3.88650904
9Keratoconus (HP:0000563)3.83586197
10Increased corneal curvature (HP:0100692)3.83586197
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.78184186
12Pigmentary retinal degeneration (HP:0001146)3.70609115
13Decreased central vision (HP:0007663)3.60792770
14Pendular nystagmus (HP:0012043)3.29654639
15Dyschromatopsia (HP:0007641)3.19539069
16Attenuation of retinal blood vessels (HP:0007843)2.90261124
17Severe visual impairment (HP:0001141)2.77821798
18Male infertility (HP:0003251)2.76131578
19Congenital primary aphakia (HP:0007707)2.74725739
20Choroideremia (HP:0001139)2.71785805
21Gait imbalance (HP:0002141)2.71400153
22Type II diabetes mellitus (HP:0005978)2.70902606
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62038893
24Vaginal atresia (HP:0000148)2.61566544
25Chromsome breakage (HP:0040012)2.58971003
26Retinitis pigmentosa (HP:0000510)2.58448055
27Vitreoretinal degeneration (HP:0000655)2.57951658
28Abnormality of the fovea (HP:0000493)2.57510527
29Genital tract atresia (HP:0001827)2.56628082
30Septo-optic dysplasia (HP:0100842)2.54200711
31Right ventricular cardiomyopathy (HP:0011663)2.52406085
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.52085070
33Nephrogenic diabetes insipidus (HP:0009806)2.49816460
34Posterior subcapsular cataract (HP:0007787)2.49660762
35Myelomeningocele (HP:0002475)2.45585530
36Congenital sensorineural hearing impairment (HP:0008527)2.43265885
37Reticulocytopenia (HP:0001896)2.42776910
38Absent eyebrow (HP:0002223)2.40875433
39Photophobia (HP:0000613)2.40498611
40Medial flaring of the eyebrow (HP:0010747)2.37139838
41Cone-rod dystrophy (HP:0000548)2.36022680
42Single umbilical artery (HP:0001195)2.35601371
43Abnormality of the fetal cardiovascular system (HP:0010948)2.35601371
44Abnormal umbilical cord blood vessels (HP:0011403)2.35601371
45Colon cancer (HP:0003003)2.34872571
46Abnormal ventriculo-arterial connection (HP:0011563)2.34100552
47Transposition of the great arteries (HP:0001669)2.34100552
48Abnormal connection of the cardiac segments (HP:0011545)2.34100552
49Hypoplasia of the fovea (HP:0007750)2.33737553
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.33737553
51Cholecystitis (HP:0001082)2.27278373
52Abnormal gallbladder physiology (HP:0012438)2.27278373
53Aplasia involving bones of the extremities (HP:0009825)2.26967504
54Aplasia involving bones of the upper limbs (HP:0009823)2.26967504
55Aplasia of the phalanges of the hand (HP:0009802)2.26967504
56Selective tooth agenesis (HP:0001592)2.26554073
57Maternal diabetes (HP:0009800)2.22301269
58Retinal dysplasia (HP:0007973)2.22157862
59Short middle phalanx of the 5th finger (HP:0004220)2.21271839
60Abnormal lung lobation (HP:0002101)2.19075287
61Abnormality of the umbilical cord (HP:0010881)2.16369860
62Bifid tongue (HP:0010297)2.15579231
63Multiple enchondromatosis (HP:0005701)2.14371744
64Choanal stenosis (HP:0000452)2.13978054
65Congenital malformation of the right heart (HP:0011723)2.12962927
66Double outlet right ventricle (HP:0001719)2.12962927
67Bilateral microphthalmos (HP:0007633)2.12690884
68Neurofibrillary tangles (HP:0002185)2.11500723
69Missing ribs (HP:0000921)2.09754003
70Increased nuchal translucency (HP:0010880)2.08959250
71Poor coordination (HP:0002370)2.07966682
72Absent radius (HP:0003974)2.07877025
73Partial duplication of thumb phalanx (HP:0009944)2.07620071
74Nephroblastoma (Wilms tumor) (HP:0002667)2.07540564
75Hepatoblastoma (HP:0002884)2.06083325
76Embryonal renal neoplasm (HP:0011794)2.05087282
77Proximal placement of thumb (HP:0009623)2.04784927
78Deviation of the thumb (HP:0009603)2.04671561
79Ventricular fibrillation (HP:0001663)2.02636822
80Subcapsular cataract (HP:0000523)2.01099596
81Duplication of thumb phalanx (HP:0009942)2.00119436
82Facial cleft (HP:0002006)1.99700040
83Arterial tortuosity (HP:0005116)1.99522382
84Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99044620
85Macular degeneration (HP:0000608)1.98907009
86Spastic diplegia (HP:0001264)1.91460021
87Aplasia involving forearm bones (HP:0009822)1.90825871
88Absent forearm bone (HP:0003953)1.90825871
89Aplasia/hypoplasia of the humerus (HP:0006507)1.90285448
90Short humerus (HP:0005792)1.90012197
91Vascular tortuosity (HP:0004948)1.88586401
92Abnormality of the lacrimal duct (HP:0011481)1.88189470
93Anophthalmia (HP:0000528)1.87849463
94Epileptic encephalopathy (HP:0200134)1.87457428
95Ectopic anus (HP:0004397)1.87432185
96Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.86184555
97Progressive muscle weakness (HP:0003323)1.85632177
98Microglossia (HP:0000171)1.84698406
99Meckel diverticulum (HP:0002245)1.84087505
100Myokymia (HP:0002411)1.82725703
101Adrenal hypoplasia (HP:0000835)1.82545173
102Preaxial foot polydactyly (HP:0001841)1.82064782
103Abdominal situs inversus (HP:0003363)1.81980211
104Abnormality of abdominal situs (HP:0011620)1.81980211
105Cutaneous syndactyly (HP:0012725)1.77771305
106Partial duplication of the phalanx of hand (HP:0009999)1.75941477
107Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.75685558
108Absence seizures (HP:0002121)1.74778285
109Ventricular tachycardia (HP:0004756)1.74384973
110Absent septum pellucidum (HP:0001331)1.73687289
111Back pain (HP:0003418)1.73576319
112Aplasia/Hypoplasia of the lens (HP:0008063)1.73528711
113Abnormality of cochlea (HP:0000375)1.72952279
114Anal stenosis (HP:0002025)1.72255802
115Atonic seizures (HP:0010819)1.72095668
116Constricted visual fields (HP:0001133)1.71931255
117Atresia of the external auditory canal (HP:0000413)1.70469286
118Aplasia/Hypoplasia affecting the retina (HP:0008061)1.70410129
119Esophageal atresia (HP:0002032)1.68607968
120Skull defect (HP:0001362)1.68315904
121Birth length less than 3rd percentile (HP:0003561)1.68312336
122Broad foot (HP:0001769)1.67880141
123Vertebral clefting (HP:0008428)1.66281019
124Pheochromocytoma (HP:0002666)1.66128798
125Stenosis of the external auditory canal (HP:0000402)1.65956294
126Pterygium (HP:0001059)1.65880020
127Abnormality of the ileum (HP:0001549)1.65540777
128Cutaneous finger syndactyly (HP:0010554)1.65188314
129Coronal craniosynostosis (HP:0004440)1.64888438
130Triphalangeal thumb (HP:0001199)1.64079073
131Absent eyelashes (HP:0000561)1.61909330
132Horseshoe kidney (HP:0000085)1.61737101
133Type II lissencephaly (HP:0007260)1.61373211
134Rectal fistula (HP:0100590)1.61247092
135Rectovaginal fistula (HP:0000143)1.61247092
136Exercise-induced muscle cramps (HP:0003710)1.60630320
137Cerebral hypomyelination (HP:0006808)1.60359495
138Patent foramen ovale (HP:0001655)1.60035829
139Abnormality of the nasolacrimal system (HP:0000614)1.58453608
140Cerebellar dysplasia (HP:0007033)1.58371436
141Aplasia/Hypoplasia of the macula (HP:0008059)1.58052745
142Abnormality of glycolysis (HP:0004366)1.57851806
143Increased serum pyruvate (HP:0003542)1.57851806
144Short hallux (HP:0010109)1.57390987
145Degeneration of the lateral corticospinal tracts (HP:0002314)1.57100956
146Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.57100956
147Aplasia/Hypoplasia of the uvula (HP:0010293)1.56672214
148Ankle clonus (HP:0011448)1.55866108
149Prolonged QT interval (HP:0001657)1.55351996
150Humeroradial synostosis (HP:0003041)1.55199081
151Synostosis involving the elbow (HP:0003938)1.55199081
152Preauricular pit (HP:0004467)1.53907480
153Periauricular skin pits (HP:0100277)1.53907480
154Ependymoma (HP:0002888)1.53792060
155Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.53041681
156High anterior hairline (HP:0009890)1.52361212
157Vaginal fistula (HP:0004320)1.51734869
158Generalized hypotonia (HP:0001290)1.51446090
159Abnormality of cells of the erythroid lineage (HP:0012130)1.50840291
160Ankyloglossia (HP:0010296)1.50698856
161Macrocytic anemia (HP:0001972)1.50385988
162Gonadotropin excess (HP:0000837)1.49507075
163Abnormality of dentin (HP:0010299)1.49394032
164Abnormality of the labia minora (HP:0012880)1.49068635
165Microvesicular hepatic steatosis (HP:0001414)1.48778954
166Aplasia/Hypoplasia of the tongue (HP:0010295)1.48664063
167Abnormalities of placenta or umbilical cord (HP:0001194)1.48334779
168Cerebral inclusion bodies (HP:0100314)1.47755113
169Hypoplastic left heart (HP:0004383)1.47561355
170Severe Myopia (HP:0011003)1.46888819
171Breast aplasia (HP:0100783)1.46871077
172Left ventricular hypertrophy (HP:0001712)1.46496629
173Gonadal dysgenesis (HP:0000133)1.46133504
174True hermaphroditism (HP:0010459)1.45513103
175Optic disc pallor (HP:0000543)1.45200206
176Hypoplasia of the uterus (HP:0000013)1.45106191
177Overriding aorta (HP:0002623)1.45022180
178Pancreatic fibrosis (HP:0100732)1.44984362
179Aplasia/Hypoplasia of the breasts (HP:0010311)1.44585726
180Neuroendocrine neoplasm (HP:0100634)1.44143427
181Dysdiadochokinesis (HP:0002075)1.43859030
182Increased circulating renin level (HP:0000848)1.43423667
183Supranuclear gaze palsy (HP:0000605)1.40765963
184Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.40548922
185Abnormality of alanine metabolism (HP:0010916)1.40548922
186Hyperalaninemia (HP:0003348)1.40548922
187Abnormality of the septum pellucidum (HP:0007375)1.39996351
188Syncope (HP:0001279)1.39692466
189Optic nerve hypoplasia (HP:0000609)1.38693102
190Labial hypoplasia (HP:0000066)1.36003374
191Hypoplastic female external genitalia (HP:0012815)1.35176284
192Cortical dysplasia (HP:0002539)1.33028838
193Progressive cerebellar ataxia (HP:0002073)1.31344873
194Symphalangism affecting the phalanges of the hand (HP:0009773)1.31296688
195Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.29830250
196Decreased testicular size (HP:0008734)1.29513130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.56922339
2CDC73.24363715
3PRKD33.10660281
4STK38L2.88115235
5MOS2.59854252
6KSR22.50670058
7BUB12.39874805
8VRK22.37355828
9NEK12.33936648
10LATS22.32142360
11PAK62.29335767
12STK392.23979547
13BMPR22.22688586
14TSSK62.22615530
15TAF12.05205496
16SCYL22.03403275
17MKNK11.97999826
18SRPK11.96874183
19WNK41.94926326
20MAP3K101.88949331
21LATS11.82458749
22MAP3K41.81089785
23MKNK21.76895827
24WEE11.76826290
25MAP3K91.74114606
26SMG11.68966314
27NME21.67376681
28BRAF1.64641383
29TTK1.64031400
30PINK11.63169730
31OXSR11.62991833
32GRK11.56194598
33FER1.45870469
34ARAF1.44859751
35EEF2K1.43987662
36MAP3K61.41288562
37ERBB41.39773917
38PAK31.39638764
39LIMK11.37143114
40NEK21.36314584
41TNIK1.33235057
42BRSK21.32747066
43WNK31.32036020
44PLK41.31051801
45SGK2231.27905385
46SGK4941.27905385
47MET1.27419014
48PNCK1.26725040
49PKN21.25412088
50EIF2AK11.25353493
51DMPK1.23267221
52CDK71.23246228
53LMTK21.22309493
54PAK41.21574918
55EPHA21.20130700
56NTRK11.20049703
57STK31.19926167
58MAP3K131.19255262
59FLT31.18698250
60PDK41.17714496
61PDK31.17714496
62OBSCN1.16225479
63STK381.15940341
64WNK11.15653630
65PHKG11.14514287
66PHKG21.14514287
67CDK121.14459800
68BCR1.13784829
69CAMK2D1.12475111
70PLK21.12313602
71TIE11.06697332
72EPHA41.05647836
73MUSK1.03945255
74MAPKAPK51.00596796
75MST40.99550298
76AURKB0.96353010
77DDR20.94987202
78TTN0.94612830
79ATR0.94418867
80ROCK20.94018636
81BRSK10.93344140
82PDK20.92505586
83MINK10.90616874
84NUAK10.90603320
85MAP2K70.90510515
86KSR10.89887164
87ZAK0.88144223
88KDR0.87761709
89TRIM280.85499025
90CAMK2A0.85360858
91MELK0.85241865
92CHEK10.83946490
93NME10.83579921
94TYRO30.83043933
95PASK0.82469135
96BRD40.81945361
97CSNK1G30.81003844
98RET0.80982687
99ICK0.77416358
100ALK0.76116617
101CSNK1G20.74880501
102DYRK20.74810516
103PRKG20.74596237
104PTK20.74477451
105ATM0.73490660
106BMX0.73408366
107AKT20.72696254
108CDK140.72317870
109EIF2AK20.71527792
110CAMK2G0.69588976
111CSNK1G10.67363498
112DYRK1A0.67286693
113EIF2AK30.66794899
114MAP3K80.65532448
115TESK20.64155075
116MAPKAPK30.61593136
117CDK10.61341178
118MAPK130.61235577
119STK160.60915284
120FGFR10.60672784
121MAP2K40.60612905
122STK240.60185247
123PRKAA10.60005525
124MAP3K120.58541017
125PRKD20.58403621
126RAF10.58310180
127EPHA30.58297584
128FGFR20.57556797
129VRK10.57554642
130CSNK1A1L0.56492617
131CAMK2B0.56179573
132RIPK10.56075940
133CDK150.56065986
134CDK20.56023966
135PDGFRA0.55173967
136CDK90.53511836
137CDK40.53333419
138RPS6KA40.52454947
139MTOR0.51975438
140STK40.51348629
141CDK180.51226602
142PRKCE0.49794315
143MST1R0.48672904
144TRIB30.48627137
145ROCK10.48383998
146CHEK20.48003904
147MAP2K10.47602980
148CDK11A0.47251418
149PRKDC0.45394660
150ILK0.45035838
151CDK80.44532543
152CDK190.44240692
153CSNK2A20.43894464
154DYRK30.43728790
155AURKA0.42649302
156PLK30.42304716
157CDK30.42285131
158CDK60.41083745
159PLK10.40040024
160LRRK20.39807288
161CSNK2A10.39630112
162TAOK30.38031888
163CDK50.37451835
164AKT30.35717556
165PAK20.35089091
166PRKAA20.34234325
167BCKDK0.33116572
168CAMK1G0.32912651
169RPS6KB20.32202184
170NTRK30.31439395
171MAP3K20.30679616
172CSNK1E0.29787814

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.89785705
2DNA replication_Homo sapiens_hsa030303.16910236
3Mismatch repair_Homo sapiens_hsa034302.77073350
4Synaptic vesicle cycle_Homo sapiens_hsa047212.74653856
5Ribosome_Homo sapiens_hsa030102.40417483
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.39278786
7RNA transport_Homo sapiens_hsa030132.22252447
8GABAergic synapse_Homo sapiens_hsa047272.18790717
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09218927
10Circadian rhythm_Homo sapiens_hsa047102.06056771
11Non-homologous end-joining_Homo sapiens_hsa034502.05463467
12Spliceosome_Homo sapiens_hsa030402.00966324
13Cell cycle_Homo sapiens_hsa041101.96853925
14Base excision repair_Homo sapiens_hsa034101.91464422
15Nicotine addiction_Homo sapiens_hsa050331.88610919
16One carbon pool by folate_Homo sapiens_hsa006701.84472847
17Ovarian steroidogenesis_Homo sapiens_hsa049131.76321201
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71593953
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70534490
20mRNA surveillance pathway_Homo sapiens_hsa030151.63068593
21Homologous recombination_Homo sapiens_hsa034401.62148390
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60060405
23Proteasome_Homo sapiens_hsa030501.51959283
24Morphine addiction_Homo sapiens_hsa050321.51628249
25Collecting duct acid secretion_Homo sapiens_hsa049661.48836516
26Nucleotide excision repair_Homo sapiens_hsa034201.48141782
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45055681
28Circadian entrainment_Homo sapiens_hsa047131.45029541
29Pyruvate metabolism_Homo sapiens_hsa006201.43564517
30Selenocompound metabolism_Homo sapiens_hsa004501.43024405
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42875722
32Insulin secretion_Homo sapiens_hsa049111.42119210
33Thyroid cancer_Homo sapiens_hsa052161.38511993
34Fatty acid elongation_Homo sapiens_hsa000621.38327645
35RNA polymerase_Homo sapiens_hsa030201.37339264
36Glutamatergic synapse_Homo sapiens_hsa047241.31874289
37Vibrio cholerae infection_Homo sapiens_hsa051101.31693669
38Fanconi anemia pathway_Homo sapiens_hsa034601.31664891
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30611834
40Ether lipid metabolism_Homo sapiens_hsa005651.26445234
41Serotonergic synapse_Homo sapiens_hsa047261.24437199
42Cardiac muscle contraction_Homo sapiens_hsa042601.24409514
43Adherens junction_Homo sapiens_hsa045201.24113945
44Olfactory transduction_Homo sapiens_hsa047401.23599069
45Linoleic acid metabolism_Homo sapiens_hsa005911.23335923
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21793772
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20890849
48Pyrimidine metabolism_Homo sapiens_hsa002401.16102239
49Hedgehog signaling pathway_Homo sapiens_hsa043401.14436071
50Oocyte meiosis_Homo sapiens_hsa041141.13829067
51Cholinergic synapse_Homo sapiens_hsa047251.13809998
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13303979
53Dopaminergic synapse_Homo sapiens_hsa047281.13250273
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12381787
55Hippo signaling pathway_Homo sapiens_hsa043901.11808997
56Salivary secretion_Homo sapiens_hsa049701.09300589
57Pentose phosphate pathway_Homo sapiens_hsa000301.09292055
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.07382870
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05169914
60Tight junction_Homo sapiens_hsa045301.03099783
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01684370
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98364079
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98082982
64Oxidative phosphorylation_Homo sapiens_hsa001900.97433324
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95645647
66Renin secretion_Homo sapiens_hsa049240.95069163
67Sphingolipid metabolism_Homo sapiens_hsa006000.94584059
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93587197
69Gastric acid secretion_Homo sapiens_hsa049710.92759134
70Biosynthesis of amino acids_Homo sapiens_hsa012300.92396750
71N-Glycan biosynthesis_Homo sapiens_hsa005100.92063190
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91390586
73Propanoate metabolism_Homo sapiens_hsa006400.90438682
74Protein export_Homo sapiens_hsa030600.90334604
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89551966
76Dilated cardiomyopathy_Homo sapiens_hsa054140.88343755
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87933486
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87560169
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86698854
80Mineral absorption_Homo sapiens_hsa049780.86563499
81Purine metabolism_Homo sapiens_hsa002300.86063798
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85122218
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.84805439
84Oxytocin signaling pathway_Homo sapiens_hsa049210.82747800
85GnRH signaling pathway_Homo sapiens_hsa049120.82120442
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81795368
87Gap junction_Homo sapiens_hsa045400.81070887
88Glutathione metabolism_Homo sapiens_hsa004800.80028909
89Fatty acid metabolism_Homo sapiens_hsa012120.79081423
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78677305
91Pancreatic secretion_Homo sapiens_hsa049720.74656295
92Long-term depression_Homo sapiens_hsa047300.74644008
93Taste transduction_Homo sapiens_hsa047420.73864146
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.73547135
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72915299
96Galactose metabolism_Homo sapiens_hsa000520.68200571
97MicroRNAs in cancer_Homo sapiens_hsa052060.68097150
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67897910
99Carbon metabolism_Homo sapiens_hsa012000.67282081
100Arginine biosynthesis_Homo sapiens_hsa002200.67240370
101Sulfur relay system_Homo sapiens_hsa041220.67126828
102Lysine degradation_Homo sapiens_hsa003100.66845395
103p53 signaling pathway_Homo sapiens_hsa041150.66190952
104Parkinsons disease_Homo sapiens_hsa050120.64979738
105Basal cell carcinoma_Homo sapiens_hsa052170.64585310
106RNA degradation_Homo sapiens_hsa030180.64344830
107Cocaine addiction_Homo sapiens_hsa050300.63774115
108Melanogenesis_Homo sapiens_hsa049160.63486263
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63205863
110TGF-beta signaling pathway_Homo sapiens_hsa043500.62412856
111Huntingtons disease_Homo sapiens_hsa050160.62089086
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61440772
113Thyroid hormone synthesis_Homo sapiens_hsa049180.60442602
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.59565571
115Melanoma_Homo sapiens_hsa052180.59517398
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59277918
117Protein digestion and absorption_Homo sapiens_hsa049740.58481183
118cAMP signaling pathway_Homo sapiens_hsa040240.57903754
119Axon guidance_Homo sapiens_hsa043600.57235614
120Wnt signaling pathway_Homo sapiens_hsa043100.56401914
121Arginine and proline metabolism_Homo sapiens_hsa003300.55935215
122Basal transcription factors_Homo sapiens_hsa030220.55400239
123Ras signaling pathway_Homo sapiens_hsa040140.55086281
124Amphetamine addiction_Homo sapiens_hsa050310.53934364
125Folate biosynthesis_Homo sapiens_hsa007900.53396714
126Alzheimers disease_Homo sapiens_hsa050100.53202442
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52437873
128Glycerolipid metabolism_Homo sapiens_hsa005610.50572336
129Steroid biosynthesis_Homo sapiens_hsa001000.49739641
130Small cell lung cancer_Homo sapiens_hsa052220.48031115
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47700674
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.46458637
133Metabolic pathways_Homo sapiens_hsa011000.46055856
134Bile secretion_Homo sapiens_hsa049760.45591877
135Butanoate metabolism_Homo sapiens_hsa006500.44911774
136Glucagon signaling pathway_Homo sapiens_hsa049220.44632252
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44089484
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43923347
139Arachidonic acid metabolism_Homo sapiens_hsa005900.43553888
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43492422
141Renal cell carcinoma_Homo sapiens_hsa052110.43034626
142Fatty acid biosynthesis_Homo sapiens_hsa000610.42747415
143Calcium signaling pathway_Homo sapiens_hsa040200.42622011
144Proteoglycans in cancer_Homo sapiens_hsa052050.42577238
145Vitamin B6 metabolism_Homo sapiens_hsa007500.42062312
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41823193
147Fructose and mannose metabolism_Homo sapiens_hsa000510.41601776
148Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41559192
149ECM-receptor interaction_Homo sapiens_hsa045120.41499947
150Colorectal cancer_Homo sapiens_hsa052100.41045698
151Bladder cancer_Homo sapiens_hsa052190.40023392
152Vitamin digestion and absorption_Homo sapiens_hsa049770.38828920
153Endometrial cancer_Homo sapiens_hsa052130.38732967
154Pathways in cancer_Homo sapiens_hsa052000.37968018
155AMPK signaling pathway_Homo sapiens_hsa041520.32429303
156Starch and sucrose metabolism_Homo sapiens_hsa005000.32297032
157Insulin signaling pathway_Homo sapiens_hsa049100.31659686
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30042692
159Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29761058

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