LAPTM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.69516820
2positive regulation of gamma-delta T cell activation (GO:0046645)5.61848933
3regulation of B cell receptor signaling pathway (GO:0050855)5.32157256
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.29447390
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.29447390
6antigen processing and presentation of endogenous antigen (GO:0019883)5.24202774
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.78903160
8negative regulation of cell killing (GO:0031342)4.78903160
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.63653763
10modulation by symbiont of host immune response (GO:0052553)4.63653763
11positive regulation by symbiont of host defense response (GO:0052509)4.63653763
12modulation by symbiont of host defense response (GO:0052031)4.63653763
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.63653763
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.63653763
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.54997289
16detection of other organism (GO:0098543)4.48141219
17detection of bacterium (GO:0016045)4.35183013
18immunoglobulin mediated immune response (GO:0016064)4.17028189
19regulation of interferon-beta biosynthetic process (GO:0045357)4.15738405
20regulation of gamma-delta T cell differentiation (GO:0045586)4.13458805
21leukocyte aggregation (GO:0070486)4.13451531
22neutrophil activation involved in immune response (GO:0002283)4.10664474
23positive regulation of B cell differentiation (GO:0045579)4.05096594
24regulation of B cell differentiation (GO:0045577)4.03379750
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.98427753
26regulation of gamma-delta T cell activation (GO:0046643)3.94176476
27T cell migration (GO:0072678)3.92410062
28B cell receptor signaling pathway (GO:0050853)3.86534901
29negative thymic T cell selection (GO:0045060)3.85226248
30negative T cell selection (GO:0043383)3.84394007
31detection of external biotic stimulus (GO:0098581)3.75875036
32respiratory burst (GO:0045730)3.74781752
33tolerance induction (GO:0002507)3.71129350
34positive regulation of antigen processing and presentation (GO:0002579)3.70060673
35cellular extravasation (GO:0045123)3.69972355
36positive thymic T cell selection (GO:0045059)3.68194179
37macrophage activation involved in immune response (GO:0002281)3.66254360
38mast cell activation (GO:0045576)3.59630874
39positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.55342016
40Arp2/3 complex-mediated actin nucleation (GO:0034314)3.54011329
41positive regulation of interferon-alpha production (GO:0032727)3.49863469
42detection of molecule of bacterial origin (GO:0032490)3.48050421
43interferon-gamma production (GO:0032609)3.47729625
44response to peptidoglycan (GO:0032494)3.45066435
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.44557028
46myeloid cell activation involved in immune response (GO:0002275)3.42348349
47regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.42272336
48regulation of dendritic cell antigen processing and presentation (GO:0002604)3.39145558
49negative regulation of erythrocyte differentiation (GO:0045647)3.38847553
50regulation of interferon-alpha production (GO:0032647)3.37548333
51regulation of mast cell activation involved in immune response (GO:0033006)3.35980099
52positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.34513399
53myeloid dendritic cell activation (GO:0001773)3.34353451
54detection of biotic stimulus (GO:0009595)3.33418530
55negative regulation of phagocytosis (GO:0050765)3.32851036
56B cell mediated immunity (GO:0019724)3.32355926
57response to interleukin-15 (GO:0070672)3.31671648
58antigen processing and presentation via MHC class Ib (GO:0002475)3.31096675
59neutrophil activation (GO:0042119)3.29837894
60regulation of interleukin-12 biosynthetic process (GO:0045075)3.29560212
61leukocyte cell-cell adhesion (GO:0007159)3.27963939
62negative regulation of leukocyte mediated immunity (GO:0002704)3.27340309
63lipopolysaccharide-mediated signaling pathway (GO:0031663)3.27246149
64germinal center formation (GO:0002467)3.23872045
65regulation of myeloid leukocyte mediated immunity (GO:0002886)3.23841246
66negative regulation of interleukin-12 production (GO:0032695)3.23100792
67granulocyte activation (GO:0036230)3.21034502
68macrophage activation (GO:0042116)3.20674907
69regulation of leukocyte degranulation (GO:0043300)3.19023893
70regulation of antigen processing and presentation (GO:0002577)3.18861301
71interferon-gamma-mediated signaling pathway (GO:0060333)3.18673140
72negative regulation of T cell mediated immunity (GO:0002710)3.17946931
73defense response to protozoan (GO:0042832)3.16845158
74response to muramyl dipeptide (GO:0032495)3.16807804
75thymic T cell selection (GO:0045061)3.15572406
76positive regulation of mast cell activation involved in immune response (GO:0033008)3.13650328
77positive regulation of mast cell degranulation (GO:0043306)3.13650328
78regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.13330842
79response to type I interferon (GO:0034340)3.12668174
80type I interferon signaling pathway (GO:0060337)3.11279580
81cellular response to type I interferon (GO:0071357)3.11279580
82regulation of tolerance induction (GO:0002643)3.10206629
83myeloid dendritic cell differentiation (GO:0043011)3.07689527
84cellular response to interleukin-15 (GO:0071350)3.06721317
85response to protozoan (GO:0001562)3.05316293
86cellular response to zinc ion (GO:0071294)3.04912350
87negative regulation of granulocyte differentiation (GO:0030853)2.99606257
88T-helper 1 type immune response (GO:0042088)2.98179883
89T cell selection (GO:0045058)2.97646770
90positive T cell selection (GO:0043368)2.95942885
91pinocytosis (GO:0006907)2.95216550
92regulation of T cell tolerance induction (GO:0002664)2.93243815
93negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.92466091
94leukocyte degranulation (GO:0043299)2.92184930
95positive regulation of isotype switching (GO:0045830)2.91990289
96response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.91667785
97response to host immune response (GO:0052572)2.91667785
98activated T cell proliferation (GO:0050798)2.91218791
99antigen receptor-mediated signaling pathway (GO:0050851)2.90170735
100production of molecular mediator involved in inflammatory response (GO:0002532)2.88852401
101regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.86667919
102regulation of natural killer cell mediated immunity (GO:0002715)2.86667919
103negative regulation of cytokine production involved in immune response (GO:0002719)2.86663727
104positive regulation of mast cell activation (GO:0033005)2.86523278
105regulation of T-helper 2 cell differentiation (GO:0045628)2.86472782
106cellular response to interferon-beta (GO:0035458)2.86343171
107regulation of alpha-beta T cell proliferation (GO:0046640)2.84937169
108regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.84401310
109negative regulation of innate immune response (GO:0045824)2.83615456
110myeloid leukocyte activation (GO:0002274)2.83259936
111negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.82024722
112regulation of T cell receptor signaling pathway (GO:0050856)2.82018208
113positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.81169030
114response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.80098520
115response to host (GO:0075136)2.80098520
116response to host defenses (GO:0052200)2.80098520
117microglial cell activation (GO:0001774)2.77879549
118JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.77252029
119NIK/NF-kappaB signaling (GO:0038061)2.75818418
120mature B cell differentiation (GO:0002335)2.75275346
121cellular defense response (GO:0006968)2.73548776
122regulation of type I interferon-mediated signaling pathway (GO:0060338)2.73062281
123T cell proliferation (GO:0042098)2.72119521
124regulation of mast cell activation (GO:0033003)2.72082454
125positive regulation of interleukin-2 production (GO:0032743)2.71825331
126T cell costimulation (GO:0031295)2.70220883
127regulation of mast cell degranulation (GO:0043304)2.69807055
128regulation of interleukin-2 biosynthetic process (GO:0045076)2.69581784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.18356045
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.93975081
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.46059742
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.16651801
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.80889370
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.76717073
7E2F7_22180533_ChIP-Seq_HELA_Human3.51262599
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.48031440
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.33007499
10* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.17665050
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.11627602
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03601466
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.92521323
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.83139619
15SCL_19346495_ChIP-Seq_HPC-7_Human2.77197926
16* MYC_22102868_ChIP-Seq_BL_Human2.76516140
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.73781737
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.71330982
19VDR_21846776_ChIP-Seq_THP-1_Human2.62424409
20* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.61934277
21* SPI1_23547873_ChIP-Seq_NB4_Human2.54064085
22* MYB_26560356_Chip-Seq_TH2_Human2.53518526
23RUNX_20019798_ChIP-Seq_JUKART_Human2.51566687
24* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.43971307
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.39965397
26* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.39539367
27MAF_26560356_Chip-Seq_TH1_Human2.38353817
28* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.23159920
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.19732414
30* VDR_24763502_ChIP-Seq_THP-1_Human2.16502224
31* MYB_26560356_Chip-Seq_TH1_Human2.13471867
32* BP1_19119308_ChIP-ChIP_Hs578T_Human2.11403774
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.06317720
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06299948
35* UTX_26944678_Chip-Seq_JUKART_Human2.01998502
36* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99379277
37* SPI1_23127762_ChIP-Seq_K562_Human1.90790701
38* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87012173
39* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86913559
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.85135548
41* TCF7_22412390_ChIP-Seq_EML_Mouse1.79908769
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75377985
43* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59141940
44* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58659888
45* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58599205
46PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.57891544
47PU_27001747_Chip-Seq_BMDM_Mouse1.57711182
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54888822
49* GATA3_27048872_Chip-Seq_THYMUS_Human1.52989015
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50059891
51* MAF_26560356_Chip-Seq_TH2_Human1.48227632
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47656504
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44834610
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.44347332
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41631910
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39733814
57* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37921878
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33790789
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.32179290
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31646610
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31065150
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30475966
63* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27278849
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24292070
65KDM2B_26808549_Chip-Seq_DND41_Human1.22434295
66* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22194420
67* ELK3_25401928_ChIP-Seq_HUVEC_Human1.20272250
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19489294
69CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17242879
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17140346
71GATA3_26560356_Chip-Seq_TH2_Human1.17026597
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16247987
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15882232
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15398318
75* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14722916
76* GATA1_19941826_ChIP-Seq_K562_Human1.14124911
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13921232
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.13372541
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12604772
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11762009
81* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11676336
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10607016
83BCOR_27268052_Chip-Seq_Bcells_Human1.10039220
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06733826
85* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05525475
86GATA1_22025678_ChIP-Seq_K562_Human1.04918314
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04094442
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.03406656
89VDR_24787735_ChIP-Seq_THP-1_Human1.02497028
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02129664
91* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01851395
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01556654
93CIITA_25753668_ChIP-Seq_RAJI_Human1.00612797
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97813981
95* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97388859
96KDM2B_26808549_Chip-Seq_JURKAT_Human0.96510084
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.96000280
98TFEB_21752829_ChIP-Seq_HELA_Human0.92721222
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88481585
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87434337
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84145858
102* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83737505
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83294663
104SPI1_20517297_ChIP-Seq_HL60_Human0.82638362
105* LXR_22292898_ChIP-Seq_THP-1_Human0.80539032
106* NCOR1_26117541_ChIP-Seq_K562_Human0.79500290
107E2F4_17652178_ChIP-ChIP_JURKAT_Human0.79302512
108VDR_23849224_ChIP-Seq_CD4+_Human0.75349575
109* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73480021
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.73474270
111BCL6_27268052_Chip-Seq_Bcells_Human0.73002250
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72745630
113* GATA2_19941826_ChIP-Seq_K562_Human0.71529398
114* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.71376523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.48290253
2MP0005671_abnormal_response_to3.47670497
3MP0003436_decreased_susceptibility_to3.36261106
4MP0000685_abnormal_immune_system3.23478961
5MP0005000_abnormal_immune_tolerance3.14526862
6MP0001800_abnormal_humoral_immune3.11642406
7MP0005387_immune_system_phenotype3.06970829
8MP0001790_abnormal_immune_system3.06970829
9MP0006082_CNS_inflammation3.05573760
10MP0009785_altered_susceptibility_to3.02588390
11MP0002452_abnormal_antigen_presenting2.89663201
12MP0002419_abnormal_innate_immunity2.87265703
13MP0005025_abnormal_response_to2.86917561
14MP0003303_peritoneal_inflammation2.83459578
15* MP0002148_abnormal_hypersensitivity_rea2.75828627
16* MP0002723_abnormal_immune_serum2.73399756
17* MP0002420_abnormal_adaptive_immunity2.68593407
18* MP0001819_abnormal_immune_cell2.67308103
19MP0003763_abnormal_thymus_physiology2.59610998
20MP0005464_abnormal_platelet_physiology2.44622695
21MP0005058_abnormal_lysosome_morphology2.43344068
22* MP0002398_abnormal_bone_marrow2.31656262
23MP0003724_increased_susceptibility_to2.31450400
24MP0002405_respiratory_system_inflammati2.27109337
25MP0009333_abnormal_splenocyte_physiolog2.25408882
26MP0002396_abnormal_hematopoietic_system2.20410633
27* MP0000716_abnormal_immune_system2.19302392
28MP0004510_myositis2.08009380
29MP0000689_abnormal_spleen_morphology2.04141481
30MP0002166_altered_tumor_susceptibility2.03613276
31MP0002722_abnormal_immune_system1.94804131
32MP0003300_gastrointestinal_ulcer1.91770399
33MP0003172_abnormal_lysosome_physiology1.90230391
34MP0004947_skin_inflammation1.90214794
35MP0010155_abnormal_intestine_physiology1.88954294
36MP0001845_abnormal_inflammatory_respons1.88650237
37MP0001853_heart_inflammation1.87674230
38* MP0002429_abnormal_blood_cell1.83576739
39MP0001873_stomach_inflammation1.78706940
40MP0002006_tumorigenesis1.77406980
41MP0001533_abnormal_skeleton_physiology1.74246996
42MP0000465_gastrointestinal_hemorrhage1.65420843
43MP0005310_abnormal_salivary_gland1.61306625
44MP0000703_abnormal_thymus_morphology1.54411398
45MP0005451_abnormal_body_composition1.52890586
46MP0003191_abnormal_cellular_cholesterol1.52192788
47MP0004808_abnormal_hematopoietic_stem1.52182088
48MP0005397_hematopoietic_system_phenotyp1.50470119
49MP0001545_abnormal_hematopoietic_system1.50470119
50MP0009278_abnormal_bone_marrow1.48376403
51MP0008469_abnormal_protein_level1.47053543
52MP0002933_joint_inflammation1.46391141
53MP0003448_altered_tumor_morphology1.40141707
54MP0008260_abnormal_autophagy1.37692474
55MP0003866_abnormal_defecation1.35909490
56MP0000858_altered_metastatic_potential1.35225228
57MP0000490_abnormal_crypts_of1.30295993
58MP0005174_abnormal_tail_pigmentation1.29470871
59MP0000343_altered_response_to1.27849950
60MP0001851_eye_inflammation1.27568110
61MP0009840_abnormal_foam_cell1.19171864
62MP0003075_altered_response_to1.14138202
63MP0003183_abnormal_peptide_metabolism1.07465785
64MP0003806_abnormal_nucleotide_metabolis1.05847138
65MP0002998_abnormal_bone_remodeling1.05202280
66MP0004883_abnormal_blood_vessel1.03168272
67MP0009764_decreased_sensitivity_to1.00671028
68MP0005166_decreased_susceptibility_to0.96598024
69MP0010307_abnormal_tumor_latency0.95883831
70MP0002277_abnormal_respiratory_mucosa0.94794019
71MP0002019_abnormal_tumor_incidence0.87583244
72MP0008004_abnormal_stomach_pH0.86780322
73MP0009763_increased_sensitivity_to0.85768024
74MP0010352_gastrointestinal_tract_polyps0.84224361
75MP0005164_abnormal_response_to0.83552713
76MP0004381_abnormal_hair_follicle0.81133463
77MP0003828_pulmonary_edema0.80919764
78MP0005167_abnormal_blood-brain_barrier0.78384232
79MP0005075_abnormal_melanosome_morpholog0.77303743
80MP0005390_skeleton_phenotype0.76341317
81MP0000249_abnormal_blood_vessel0.75626844
82MP0002132_abnormal_respiratory_system0.74462629
83MP0003566_abnormal_cell_adhesion0.72041975
84MP0000604_amyloidosis0.71612309
85MP0005076_abnormal_cell_differentiation0.69489995
86MP0000015_abnormal_ear_pigmentation0.68529871
87MP0009765_abnormal_xenobiotic_induced0.68278657
88MP0005023_abnormal_wound_healing0.67906634
89MP0001663_abnormal_digestive_system0.67826334
90MP0008057_abnormal_DNA_replication0.66562898
91MP0000920_abnormal_myelination0.64432998
92MP0003795_abnormal_bone_structure0.63798554
93MP0008874_decreased_physiological_sensi0.63221215
94MP0002139_abnormal_hepatobiliary_system0.62796588
95MP0002136_abnormal_kidney_physiology0.62366074
96MP0003690_abnormal_glial_cell0.61833888
97MP0008007_abnormal_cellular_replicative0.60794234
98MP0003656_abnormal_erythrocyte_physiolo0.60326868
99MP0008873_increased_physiological_sensi0.58767885
100MP0003091_abnormal_cell_migration0.56991362
101MP0002095_abnormal_skin_pigmentation0.56791732
102MP0000371_diluted_coat_color0.55769417
103MP0000313_abnormal_cell_death0.52734311
104MP0002138_abnormal_hepatobiliary_system0.51834570
105MP0000569_abnormal_digit_pigmentation0.51746421
106MP0003077_abnormal_cell_cycle0.50903654
107MP0002009_preneoplasia0.49169732
108MP0003453_abnormal_keratinocyte_physiol0.48608197
109MP0000609_abnormal_liver_physiology0.48551851
110MP0010094_abnormal_chromosome_stability0.48544417
111MP0003045_fibrosis0.48104633
112MP0000598_abnormal_liver_morphology0.47058744
113MP0005319_abnormal_enzyme/_coenzyme0.46770716
114MP0005381_digestive/alimentary_phenotyp0.46298372
115MP0002693_abnormal_pancreas_physiology0.46128325
116MP0003329_amyloid_beta_deposits0.46125752
117MP0004782_abnormal_surfactant_physiolog0.44935189
118MP0000477_abnormal_intestine_morphology0.43575102
119MP0001915_intracranial_hemorrhage0.42976054
120MP0005584_abnormal_enzyme/coenzyme_acti0.42481327

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.13695938
2Eczematoid dermatitis (HP:0000976)5.58228584
3Recurrent bacterial skin infections (HP:0005406)5.29284544
4Elevated erythrocyte sedimentation rate (HP:0003565)4.53167368
5Systemic lupus erythematosus (HP:0002725)4.46370124
6Myositis (HP:0100614)4.40078234
7Recurrent gram-negative bacterial infections (HP:0005420)4.31413712
8Recurrent fungal infections (HP:0002841)4.29703409
9Recurrent viral infections (HP:0004429)4.03805571
10IgM deficiency (HP:0002850)4.02852516
11Abnormality of macrophages (HP:0004311)3.86132446
12Chronic otitis media (HP:0000389)3.84556011
13Vacuolated lymphocytes (HP:0001922)3.78196365
14Recurrent skin infections (HP:0001581)3.78061501
15Increased cerebral lipofuscin (HP:0011813)3.64111927
16Mediastinal lymphadenopathy (HP:0100721)3.63474597
17Obstructive lung disease (HP:0006536)3.56014103
18Chronic obstructive pulmonary disease (HP:0006510)3.56014103
19Recurrent cutaneous fungal infections (HP:0011370)3.50891234
20Chronic mucocutaneous candidiasis (HP:0002728)3.50891234
21Pustule (HP:0200039)3.45663623
22Meningitis (HP:0001287)3.44544002
23Cellulitis (HP:0100658)3.42551882
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.40181434
25Recurrent bronchitis (HP:0002837)3.38550285
26Orchitis (HP:0100796)3.35431038
27Nasal polyposis (HP:0100582)3.34776957
28T lymphocytopenia (HP:0005403)3.32306090
29Abnormality of T cell number (HP:0011839)3.29335181
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.26362136
31Stomatitis (HP:0010280)3.25570770
32Gastrointestinal infarctions (HP:0005244)3.21194416
33Autoimmune thrombocytopenia (HP:0001973)3.18719708
34Dysostosis multiplex (HP:0000943)3.17364622
35Panhypogammaglobulinemia (HP:0003139)3.16437335
36Abnormality of T cells (HP:0002843)3.13609313
37Petechiae (HP:0000967)3.13051263
38Vasculitis (HP:0002633)3.12403957
39Inflammation of the large intestine (HP:0002037)3.11893816
40Optic neuritis (HP:0100653)3.08503382
41Retrobulbar optic neuritis (HP:0100654)3.08503382
42Spontaneous hematomas (HP:0007420)3.05451023
43Abnormality of the nasal mucosa (HP:0000433)3.02662048
44Gingivitis (HP:0000230)3.01826710
45Gastrointestinal inflammation (HP:0004386)3.01795570
46Glomerulonephritis (HP:0000099)3.00274068
47Agammaglobulinemia (HP:0004432)2.97507321
48Colitis (HP:0002583)2.93639152
49Abnormality of glycolipid metabolism (HP:0010969)2.90644818
50Abnormality of liposaccharide metabolism (HP:0010968)2.90644818
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.90644818
52Thrombocytosis (HP:0001894)2.85922349
53Interstitial pulmonary disease (HP:0006530)2.83447853
54Leukocytosis (HP:0001974)2.82903236
55Abnormality of T cell physiology (HP:0011840)2.81692777
56Chest pain (HP:0100749)2.79717815
57Prolonged bleeding time (HP:0003010)2.71996140
58Lymphopenia (HP:0001888)2.71733552
59Keratoconjunctivitis (HP:0001096)2.71091393
60Increased IgM level (HP:0003496)2.71082029
61Periodontitis (HP:0000704)2.67393867
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.65346381
63Thyroiditis (HP:0100646)2.62597917
64Eosinophilia (HP:0001880)2.58652417
65Pulmonary infiltrates (HP:0002113)2.55638489
66Purpura (HP:0000979)2.54779663
67Mucopolysacchariduria (HP:0008155)2.52405350
68Urinary glycosaminoglycan excretion (HP:0003541)2.52405350
69IgG deficiency (HP:0004315)2.51917661
70Agnosia (HP:0010524)2.50967082
71Epistaxis (HP:0000421)2.48533687
72Disinhibition (HP:0000734)2.47110526
73Combined immunodeficiency (HP:0005387)2.44105539
74Severe combined immunodeficiency (HP:0004430)2.43563940
75Sepsis (HP:0100806)2.43244103
76Pulmonary embolism (HP:0002204)2.42687874
77Abnormality of eosinophils (HP:0001879)2.42549480
78Loss of speech (HP:0002371)2.42215150
79Arterial thrombosis (HP:0004420)2.40352492
80Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.40190332
81Osteomyelitis (HP:0002754)2.38946252
82Gastrointestinal stroma tumor (HP:0100723)2.38749418
83Amyloidosis (HP:0011034)2.37608105
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.35688660
85Abnormality of mucopolysaccharide metabolism (HP:0011020)2.35688660
86Abnormality of polysaccharide metabolism (HP:0011012)2.35688660
87Hemoptysis (HP:0002105)2.35611074
88Abnormality of B cell number (HP:0010975)2.35276672
89B lymphocytopenia (HP:0010976)2.35276672
90Granulocytopenia (HP:0001913)2.34074137
91Restrictive lung disease (HP:0002091)2.33953752
92Increased IgE level (HP:0003212)2.33772954
93Recurrent pneumonia (HP:0006532)2.33554299
94Encephalitis (HP:0002383)2.33553186
95Hematochezia (HP:0002573)2.33286988
96Increased serum ferritin (HP:0003281)2.33061969
97Chronic diarrhea (HP:0002028)2.32596209
98Autoimmune hemolytic anemia (HP:0001890)2.28082210
99Hepatosplenomegaly (HP:0001433)2.26899382
100Episodic fever (HP:0001954)2.23730351
101Abnormality of the prostate (HP:0008775)2.22450711
102Abnormality of the pleura (HP:0002103)2.21549148
103Recurrent sinusitis (HP:0011108)2.20987131
104Recurrent lower respiratory tract infections (HP:0002783)2.19540790
105Urticaria (HP:0001025)2.18766092
106Hypergammaglobulinemia (HP:0010702)2.18097928
107Gingival bleeding (HP:0000225)2.17228893
108Gangrene (HP:0100758)2.17212839
109Abnormal platelet function (HP:0011869)2.17124454
110Impaired platelet aggregation (HP:0003540)2.17124454
111Keratoconjunctivitis sicca (HP:0001097)2.12770750
112IgA deficiency (HP:0002720)2.12117557
113Anorexia (HP:0002039)2.10791426
114Verrucae (HP:0200043)2.09520474
115Papilloma (HP:0012740)2.09520474
116Emphysema (HP:0002097)2.08448869
117Polyneuropathy (HP:0001271)2.04095000
118Abnormality of iron homeostasis (HP:0011031)2.03155187

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.28179733
2TXK3.42720580
3BLK3.25848645
4TYK22.87516957
5PRPF4B2.67660934
6KIT2.64147453
7IRAK42.58913314
8ZAP702.48055632
9TBK12.45180268
10JAK32.40522096
11MAP3K142.30338893
12TGFBR22.29876579
13STK102.24596090
14CSF1R2.17790230
15ERN12.15522594
16BTK2.09429199
17IKBKE2.04050354
18SYK1.96772632
19RIPK41.96393273
20ITK1.95666754
21TEC1.84177794
22JAK11.81378950
23GRK61.70106418
24CSK1.61004455
25IKBKB1.59715732
26HCK1.59484416
27LCK1.57893576
28IRAK31.52185789
29FES1.47816149
30EEF2K1.43813537
31CLK11.42431905
32TAOK31.35537722
33MAP2K31.33602742
34TAOK11.30670527
35PKN21.30235112
36LYN1.28013923
37BMPR21.25726246
38EPHB11.25011668
39MAP3K131.19541515
40FGFR41.18922628
41NME21.17599623
42TAOK21.17196979
43LRRK21.14012361
44RPS6KA41.13275417
45PIM11.11311325
46MAP3K11.08985791
47MAP3K101.08326811
48TRIB31.06860229
49FLT31.06621708
50FGFR30.98776685
51JAK20.93991129
52MARK30.91903579
53SIK20.90670468
54CHUK0.90257508
55NLK0.89664411
56PIM20.88506695
57CDC42BPA0.81012884
58NEK90.78726365
59MATK0.77507514
60KDR0.75926418
61IRAK10.75595141
62IRAK20.69645912
63CAMKK20.68914340
64TESK20.67961560
65KSR20.66503870
66PDPK10.65759239
67PRKCH0.64220340
68MARK20.64202185
69PRKCQ0.63806467
70CDK190.63301927
71GRK70.62535737
72YES10.62141484
73CAMK1D0.60531330
74SMG10.58695218
75SIK30.58512516
76CDK40.58422612
77MAP3K110.57930847
78RPS6KA60.55851819
79PRKD20.55662133
80STK40.55390299
81MST40.55302409
82PAK40.55281680
83CDK120.54148006
84TRPM70.53785374
85TNK20.52188198
86CDK60.51847804
87CAMKK10.51551641
88TGFBR10.51489960
89MAP3K50.49987960
90PIK3CG0.49877590
91SCYL20.49707988
92FGR0.48457190
93MAPKAPK20.46648200
94PRKCD0.46342567
95PDK10.46065783
96PTK60.45429955
97MOS0.45399741
98MAP3K120.44736890
99RPS6KL10.43860291
100RPS6KC10.43860291
101MAPK40.39513532
102EGFR0.39144328
103EPHA30.37913938
104ABL10.37852371
105MAP2K60.36128587
106MAP3K80.36046067
107SIK10.34272113
108MAP3K70.33873686
109ADRBK20.33603313
110NEK20.33524979
111IGF1R0.33086845
112FYN0.32720420
113HIPK20.31958369
114TTN0.31553664
115CDK90.30222230
116MAP3K30.29075428
117MAPK120.27907149
118DAPK20.27213417
119DYRK1B0.26175377
120MAP3K60.25857193
121BMX0.25599622
122MAPK110.25060094
123MAPK70.24473036
124CAMK1G0.23560529
125ALK0.23493298
126MAP2K20.23057514
127MAPK30.22967259
128SGK30.21928379

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.42004664
2Staphylococcus aureus infection_Homo sapiens_hsa051503.05595714
3Leishmaniasis_Homo sapiens_hsa051403.04876026
4Osteoclast differentiation_Homo sapiens_hsa043802.48869870
5Other glycan degradation_Homo sapiens_hsa005112.45978884
6B cell receptor signaling pathway_Homo sapiens_hsa046622.41043848
7Antigen processing and presentation_Homo sapiens_hsa046122.37341091
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.37327163
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.35949729
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.35576656
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.27092524
12Measles_Homo sapiens_hsa051622.25312723
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.15667524
14Hematopoietic cell lineage_Homo sapiens_hsa046402.05909613
15Graft-versus-host disease_Homo sapiens_hsa053322.00803874
16Pertussis_Homo sapiens_hsa051331.98872112
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98106128
18T cell receptor signaling pathway_Homo sapiens_hsa046601.84180443
19Allograft rejection_Homo sapiens_hsa053301.83236625
20Legionellosis_Homo sapiens_hsa051341.81265986
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78834692
22Tuberculosis_Homo sapiens_hsa051521.75729835
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69967376
24* Lysosome_Homo sapiens_hsa041421.66109474
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64604429
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.59734771
27Malaria_Homo sapiens_hsa051441.58489727
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56585313
29Herpes simplex infection_Homo sapiens_hsa051681.54227923
30Toxoplasmosis_Homo sapiens_hsa051451.53393234
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.49692578
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45864865
33Chemokine signaling pathway_Homo sapiens_hsa040621.45564828
34Shigellosis_Homo sapiens_hsa051311.42341007
35Influenza A_Homo sapiens_hsa051641.42079334
36Asthma_Homo sapiens_hsa053101.36023976
37Apoptosis_Homo sapiens_hsa042101.29155372
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27855462
39Viral myocarditis_Homo sapiens_hsa054161.27645926
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.26954347
41Salmonella infection_Homo sapiens_hsa051321.25074814
42Hepatitis B_Homo sapiens_hsa051611.23479033
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22037924
44TNF signaling pathway_Homo sapiens_hsa046681.18729865
45Acute myeloid leukemia_Homo sapiens_hsa052211.17964255
46Rheumatoid arthritis_Homo sapiens_hsa053231.10178972
47Platelet activation_Homo sapiens_hsa046111.06682611
48DNA replication_Homo sapiens_hsa030300.98938908
49Chronic myeloid leukemia_Homo sapiens_hsa052200.97985770
50Pancreatic cancer_Homo sapiens_hsa052120.96649166
51Autoimmune thyroid disease_Homo sapiens_hsa053200.95911660
52Phagosome_Homo sapiens_hsa041450.94426437
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91654087
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89704047
55Epstein-Barr virus infection_Homo sapiens_hsa051690.83673297
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83092365
57Base excision repair_Homo sapiens_hsa034100.80956468
58Hepatitis C_Homo sapiens_hsa051600.77624020
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77188119
60Type I diabetes mellitus_Homo sapiens_hsa049400.74192475
61HTLV-I infection_Homo sapiens_hsa051660.69963866
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.69573461
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67225213
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64839703
65Viral carcinogenesis_Homo sapiens_hsa052030.62819362
66Mismatch repair_Homo sapiens_hsa034300.60862396
67Non-homologous end-joining_Homo sapiens_hsa034500.59953308
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59088526
69African trypanosomiasis_Homo sapiens_hsa051430.58906158
70Complement and coagulation cascades_Homo sapiens_hsa046100.55520522
71Colorectal cancer_Homo sapiens_hsa052100.54203742
72VEGF signaling pathway_Homo sapiens_hsa043700.54138778
73Caffeine metabolism_Homo sapiens_hsa002320.52858468
74Non-small cell lung cancer_Homo sapiens_hsa052230.51656359
75Endocytosis_Homo sapiens_hsa041440.49988221
76Prolactin signaling pathway_Homo sapiens_hsa049170.49269083
77Ribosome_Homo sapiens_hsa030100.49186860
78Renal cell carcinoma_Homo sapiens_hsa052110.47887723
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46813595
80Systemic lupus erythematosus_Homo sapiens_hsa053220.46544013
81Notch signaling pathway_Homo sapiens_hsa043300.46079744
82Collecting duct acid secretion_Homo sapiens_hsa049660.43341517
83p53 signaling pathway_Homo sapiens_hsa041150.43109393
84Small cell lung cancer_Homo sapiens_hsa052220.42562789
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42470801
86Amoebiasis_Homo sapiens_hsa051460.41997995
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.41806664
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.40657374
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39679985
90Prion diseases_Homo sapiens_hsa050200.36015331
91HIF-1 signaling pathway_Homo sapiens_hsa040660.35243698
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35120856
93Homologous recombination_Homo sapiens_hsa034400.31753145
94GnRH signaling pathway_Homo sapiens_hsa049120.31030111
95Bladder cancer_Homo sapiens_hsa052190.30924199
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27225976
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26985573
98mTOR signaling pathway_Homo sapiens_hsa041500.25595868
99Type II diabetes mellitus_Homo sapiens_hsa049300.25366482
100FoxO signaling pathway_Homo sapiens_hsa040680.24672092
101Choline metabolism in cancer_Homo sapiens_hsa052310.24306550
102Dorso-ventral axis formation_Homo sapiens_hsa043200.23875499
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22478886
104Spliceosome_Homo sapiens_hsa030400.21714606
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.21460043
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20853946
107N-Glycan biosynthesis_Homo sapiens_hsa005100.19507634
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19479575
109MAPK signaling pathway_Homo sapiens_hsa040100.19009350
110Pentose phosphate pathway_Homo sapiens_hsa000300.18930830
111Insulin resistance_Homo sapiens_hsa049310.18301666
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.18278540
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17086492
114Renin-angiotensin system_Homo sapiens_hsa046140.16889251
115Proteoglycans in cancer_Homo sapiens_hsa052050.16876712
116Pathways in cancer_Homo sapiens_hsa052000.15580756

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