LARP1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing domains found in the La related protein of Drosophila melanogaster. La motif-containing proteins are thought to be RNA-binding proteins, where the La motif and adjacent amino acids fold into an RNA recognition motif. The La motif is also found in proteins unrelated to the La protein. Alternative splicing has been observed at this locus and multiple variants, encoding distinct isoforms, are described. Additional splice variation has been identified but the full-length nature of these transcripts has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.65602651
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.65602651
3aromatic amino acid family catabolic process (GO:0009074)5.53777131
4indolalkylamine catabolic process (GO:0046218)5.46525375
5tryptophan catabolic process (GO:0006569)5.46525375
6indole-containing compound catabolic process (GO:0042436)5.46525375
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.43253191
8L-phenylalanine metabolic process (GO:0006558)5.43253191
9polyketide metabolic process (GO:0030638)5.31498815
10doxorubicin metabolic process (GO:0044598)5.31498815
11daunorubicin metabolic process (GO:0044597)5.31498815
12serine family amino acid catabolic process (GO:0009071)5.31087412
13tryptophan metabolic process (GO:0006568)5.14952127
14kynurenine metabolic process (GO:0070189)5.11979420
15centriole replication (GO:0007099)4.84858024
16cysteine metabolic process (GO:0006534)4.81715321
17urea metabolic process (GO:0019627)4.79380661
18urea cycle (GO:0000050)4.79380661
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.74667841
20amino-acid betaine metabolic process (GO:0006577)4.58492129
21homocysteine metabolic process (GO:0050667)4.53681210
22nitrogen cycle metabolic process (GO:0071941)4.40340679
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.38683330
24cilium or flagellum-dependent cell motility (GO:0001539)4.32552568
25bile acid biosynthetic process (GO:0006699)4.22931750
26piRNA metabolic process (GO:0034587)4.19675721
27drug catabolic process (GO:0042737)4.18852857
28aromatic amino acid family metabolic process (GO:0009072)4.16861337
29sulfur amino acid catabolic process (GO:0000098)4.15389888
30high-density lipoprotein particle remodeling (GO:0034375)4.14314482
31nuclear pore complex assembly (GO:0051292)4.10868901
32complement activation, alternative pathway (GO:0006957)4.09576119
33regulation of protein activation cascade (GO:2000257)4.07930113
34regulation of triglyceride catabolic process (GO:0010896)4.07381588
35glycine metabolic process (GO:0006544)4.07315096
36bile acid and bile salt transport (GO:0015721)4.06335440
37mitotic sister chromatid cohesion (GO:0007064)4.04055036
38glyoxylate metabolic process (GO:0046487)4.02995580
39triglyceride homeostasis (GO:0070328)4.01358484
40acylglycerol homeostasis (GO:0055090)4.01358484
41lysine catabolic process (GO:0006554)4.00921162
42lysine metabolic process (GO:0006553)4.00921162
43bile acid metabolic process (GO:0008206)4.00346628
44alpha-amino acid catabolic process (GO:1901606)3.96615115
45positive regulation of histone H3-K4 methylation (GO:0051571)3.96368652
46peptidyl-glutamic acid carboxylation (GO:0017187)3.94906194
47protein carboxylation (GO:0018214)3.94906194
48regulation of bile acid biosynthetic process (GO:0070857)3.94273207
49negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.88277372
50exogenous drug catabolic process (GO:0042738)3.86978310
51cellular biogenic amine catabolic process (GO:0042402)3.83689928
52amine catabolic process (GO:0009310)3.83689928
53regulation of complement activation (GO:0030449)3.82740040
54sperm motility (GO:0030317)3.81410843
55serine family amino acid metabolic process (GO:0009069)3.80975320
56regulation of helicase activity (GO:0051095)3.80530623
57indolalkylamine metabolic process (GO:0006586)3.78931566
58male meiosis (GO:0007140)3.73569710
59negative regulation of fibrinolysis (GO:0051918)3.73313537
60regulation of fibrinolysis (GO:0051917)3.72978011
61nuclear pore organization (GO:0006999)3.70704740
62aminoglycoside antibiotic metabolic process (GO:0030647)3.70486170
63protein-lipid complex remodeling (GO:0034368)3.66403313
64macromolecular complex remodeling (GO:0034367)3.66403313
65plasma lipoprotein particle remodeling (GO:0034369)3.66403313
66carnitine metabolic process (GO:0009437)3.66209126
67alpha-linolenic acid metabolic process (GO:0036109)3.65551183
68fusion of sperm to egg plasma membrane (GO:0007342)3.63523123
69regulation of cholesterol esterification (GO:0010872)3.63101415
70reverse cholesterol transport (GO:0043691)3.62475690
71regulation of centriole replication (GO:0046599)3.62398964
72centriole assembly (GO:0098534)3.61779313
73regulation of DNA endoreduplication (GO:0032875)3.61267799
74urate metabolic process (GO:0046415)3.57737297
75cellular amino acid catabolic process (GO:0009063)3.56878400
76phospholipid efflux (GO:0033700)3.54032273
77positive regulation of triglyceride lipase activity (GO:0061365)3.50104760
78positive regulation of lipoprotein lipase activity (GO:0051006)3.50104760
79motile cilium assembly (GO:0044458)3.47996200
80drug transmembrane transport (GO:0006855)3.47409394
81male meiosis I (GO:0007141)3.46149701
82axonemal dynein complex assembly (GO:0070286)3.44413064
83cellular glucuronidation (GO:0052695)3.43035398
84fructose metabolic process (GO:0006000)3.42439433
85coenzyme catabolic process (GO:0009109)3.42055591
86tyrosine metabolic process (GO:0006570)3.41010972
87synapsis (GO:0007129)3.38842642
88benzene-containing compound metabolic process (GO:0042537)3.33170999
89regulation of retinoic acid receptor signaling pathway (GO:0048385)3.33121211
90mitotic metaphase plate congression (GO:0007080)3.32635204
91cellular ketone body metabolic process (GO:0046950)3.32160469
92synaptonemal complex organization (GO:0070193)3.29464643
93intestinal cholesterol absorption (GO:0030299)3.29166283
94synaptonemal complex assembly (GO:0007130)3.27647524
95chromatin remodeling at centromere (GO:0031055)3.26606466
96CENP-A containing nucleosome assembly (GO:0034080)3.24438559
97fatty acid transmembrane transport (GO:1902001)3.24110854
98ribosome assembly (GO:0042255)3.23638731
99kinetochore organization (GO:0051383)3.23636946
100amino-acid betaine transport (GO:0015838)3.22721347
101carnitine transport (GO:0015879)3.22721347
102plasma lipoprotein particle clearance (GO:0034381)3.22665694
103arginine metabolic process (GO:0006525)3.22468723
104monoubiquitinated protein deubiquitination (GO:0035520)3.20421221
105negative regulation of fatty acid biosynthetic process (GO:0045717)3.19478637
106carnitine transmembrane transport (GO:1902603)3.19081840
107multicellular organism reproduction (GO:0032504)3.18881492
108carboxylic acid catabolic process (GO:0046395)3.16915004
109organic acid catabolic process (GO:0016054)3.16915004
110metaphase plate congression (GO:0051310)3.16265232
111serine family amino acid biosynthetic process (GO:0009070)3.15992737
112DNA replication checkpoint (GO:0000076)3.14926675
113nicotinamide nucleotide biosynthetic process (GO:0019359)3.14834239
114pyridine nucleotide biosynthetic process (GO:0019363)3.14834239
115NAD biosynthetic process (GO:0009435)3.14318198
116histone exchange (GO:0043486)3.13136509
117negative regulation of sterol transport (GO:0032372)3.10218702
118negative regulation of cholesterol transport (GO:0032375)3.10218702
119sister chromatid cohesion (GO:0007062)3.09489109
120sterol homeostasis (GO:0055092)3.09436483
1212-oxoglutarate metabolic process (GO:0006103)3.08749185
122regulation of meiosis I (GO:0060631)2.99300140
123attachment of spindle microtubules to kinetochore (GO:0008608)2.98642953
124meiotic chromosome segregation (GO:0045132)2.97592352
125negative regulation of DNA-dependent DNA replication (GO:2000104)2.95576738
126protein localization to kinetochore (GO:0034501)2.95207840
127kinetochore assembly (GO:0051382)2.92224878
128somatic hypermutation of immunoglobulin genes (GO:0016446)2.89240101
129somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89240101
130telomere maintenance via telomerase (GO:0007004)2.87237451
131double-strand break repair via nonhomologous end joining (GO:0006303)2.83664450
132non-recombinational repair (GO:0000726)2.83664450
133sister chromatid segregation (GO:0000819)2.83173400
134positive regulation of mitotic sister chromatid separation (GO:1901970)2.83004631
135positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.83004631
136positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.83004631
137pore complex assembly (GO:0046931)2.75791502
138DNA double-strand break processing (GO:0000729)2.73882101
139mitotic sister chromatid segregation (GO:0000070)2.73537846
140negative regulation of DNA recombination (GO:0045910)2.70784789
141protein K6-linked ubiquitination (GO:0085020)2.70456913
142single strand break repair (GO:0000012)2.67633129
143regulation of centrosome duplication (GO:0010824)2.64854162
144regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.64581141
145regulation of centrosome cycle (GO:0046605)2.64378123
146regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.58901165
147regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.58864791
148regulation of mitotic spindle checkpoint (GO:1903504)2.58864791
149protein localization to chromosome, centromeric region (GO:0071459)2.58821682
150rRNA methylation (GO:0031167)2.55885995
151somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.53861348
152somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.53861348
153isotype switching (GO:0045190)2.53861348
154rRNA modification (GO:0000154)2.51595806
155microtubule depolymerization (GO:0007019)2.50745096
156DNA damage response, detection of DNA damage (GO:0042769)2.50294668
157protoporphyrinogen IX biosynthetic process (GO:0006782)2.49843618
158spindle checkpoint (GO:0031577)2.49192314
159regulation of glucokinase activity (GO:0033131)2.48812743
160regulation of hexokinase activity (GO:1903299)2.48812743
161positive regulation of histone methylation (GO:0031062)2.48476940
162intra-S DNA damage checkpoint (GO:0031573)2.47534034
163regulation of histone H3-K9 methylation (GO:0051570)2.45721310
164resolution of meiotic recombination intermediates (GO:0000712)2.45522922
165establishment of protein localization to Golgi (GO:0072600)2.44328394
166regulation of mitotic metaphase/anaphase transition (GO:0030071)2.43626072
167regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.43626072
168heme transport (GO:0015886)2.42314337
169regulation of chromosome segregation (GO:0051983)2.42174861
170regulation of acyl-CoA biosynthetic process (GO:0050812)2.41067704
171regulation of mitotic sister chromatid separation (GO:0010965)2.40977512
172regulation of mitotic sister chromatid segregation (GO:0033047)2.40977512
173regulation of sister chromatid segregation (GO:0033045)2.40977512
174microtubule anchoring (GO:0034453)2.40244928
175somatic recombination of immunoglobulin gene segments (GO:0016447)2.39349302
176COPII vesicle coating (GO:0048208)2.39089622
177purine nucleobase biosynthetic process (GO:0009113)2.36038737
178positive regulation of chromosome segregation (GO:0051984)2.35779502
179DNA replication-independent nucleosome organization (GO:0034724)2.35683091
180DNA replication-independent nucleosome assembly (GO:0006336)2.35683091
181oxidative demethylation (GO:0070989)2.35019865
182somatic diversification of immunoglobulins (GO:0016445)2.34918223
183mitotic spindle checkpoint (GO:0071174)2.34593943
184negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.34187879
185negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.34187879
186negative regulation of mitotic sister chromatid segregation (GO:0033048)2.34187879
187negative regulation of mitotic sister chromatid separation (GO:2000816)2.34187879
188negative regulation of sister chromatid segregation (GO:0033046)2.34187879
189regulation of sister chromatid cohesion (GO:0007063)2.33981062
190pre-miRNA processing (GO:0031054)2.33022963
191mitotic G2/M transition checkpoint (GO:0044818)2.32640813
192establishment of chromosome localization (GO:0051303)2.31827959
193centrosome organization (GO:0051297)2.31728540
194negative regulation of chromosome segregation (GO:0051985)2.31445491

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.09262818
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.24243590
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.84013897
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.37152625
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.99739124
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.08057039
7E2F7_22180533_ChIP-Seq_HELA_Human4.03013585
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.76497817
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.22972779
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.17338429
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.88567725
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80194597
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.76780195
14KAP1_22055183_ChIP-Seq_ESCs_Mouse2.68368569
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.66696387
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.58864475
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.58850741
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45830537
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.43859582
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.39982126
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37700418
22ELK1_19687146_ChIP-ChIP_HELA_Human2.19839720
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.13316741
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.13245695
25FUS_26573619_Chip-Seq_HEK293_Human2.12850029
26EWS_26573619_Chip-Seq_HEK293_Human2.11772224
27IGF1R_20145208_ChIP-Seq_DFB_Human2.01638332
28GBX2_23144817_ChIP-Seq_PC3_Human2.00678372
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98105223
30TAF15_26573619_Chip-Seq_HEK293_Human1.95587839
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.92134505
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91167700
33ZNF274_21170338_ChIP-Seq_K562_Hela1.89543896
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89409748
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.86016963
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84581922
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.83734745
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80036527
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65603536
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.65438352
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63459219
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63274135
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61751537
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61537154
45P300_19829295_ChIP-Seq_ESCs_Human1.61251627
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59192802
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59143221
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.54744781
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53773072
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.53291239
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51925976
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51057407
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50135597
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.47627921
55STAT1_17558387_ChIP-Seq_HELA_Human1.46092136
56ER_23166858_ChIP-Seq_MCF-7_Human1.44198148
57IRF1_19129219_ChIP-ChIP_H3396_Human1.41279219
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40613116
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.40526862
60VDR_23849224_ChIP-Seq_CD4+_Human1.40454804
61RXRA_24833708_ChIP-Seq_LIVER_Mouse1.40101363
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39632984
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39184655
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37385929
65HTT_18923047_ChIP-ChIP_STHdh_Human1.35780041
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35626547
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35043890
68HNF4A_19822575_ChIP-Seq_HepG2_Human1.34113760
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33955756
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.31026366
71GATA4_25053715_ChIP-Seq_YYC3_Human1.30505883
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29257156
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28710300
74* STAT3_23295773_ChIP-Seq_U87_Human1.27962289
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27844073
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.27480589
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27206211
78ZNF263_19887448_ChIP-Seq_K562_Human1.26815947
79SMAD4_21799915_ChIP-Seq_A2780_Human1.24795221
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.24749771
81* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24397956
82OCT4_21477851_ChIP-Seq_ESCs_Mouse1.24195150
83TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.23751241
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23336169
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.22394976
86MYC_18940864_ChIP-ChIP_HL60_Human1.22348705
87* TCF4_23295773_ChIP-Seq_U87_Human1.19262651
88* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18491050
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16492982
90FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15171009
91* CBP_20019798_ChIP-Seq_JUKART_Human1.14624759
92* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14624759
93VDR_22108803_ChIP-Seq_LS180_Human1.13364598
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11550398
95* E2F1_18555785_Chip-Seq_ESCs_Mouse1.11042227
96FOXA2_19822575_ChIP-Seq_HepG2_Human1.10847509
97FOXP3_21729870_ChIP-Seq_TREG_Human1.10681586
98TP53_22573176_ChIP-Seq_HFKS_Human1.09657664
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09105507
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08522264
101CDX2_22108803_ChIP-Seq_LS180_Human1.07375992
102* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06838525
103RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06755366
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05823046
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05673880
106MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05635134
107AR_21909140_ChIP-Seq_LNCAP_Human1.05459745
108CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05341227
109HNFA_21074721_ChIP-Seq_CACO-2_Human1.04936613
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04210821
111BCAT_22108803_ChIP-Seq_LS180_Human1.03392249
112OCT4_18555785_Chip-Seq_ESCs_Mouse1.03346787
113JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02454738
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.01422874
115TCF4_22108803_ChIP-Seq_LS180_Human0.98916357
116ESET_19884257_ChIP-Seq_ESCs_Mouse0.98379719
117TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98366135
118NANOG_16153702_ChIP-ChIP_HESCs_Human0.97395894
119PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96961285
120P300_18555785_Chip-Seq_ESCs_Mouse0.96957311
121NANOG_19829295_ChIP-Seq_ESCs_Human0.96809808
122SOX2_19829295_ChIP-Seq_ESCs_Human0.96809808
123RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96769013
124CMYC_18555785_Chip-Seq_ESCs_Mouse0.96479675
125PHF8_20622853_ChIP-Seq_HELA_Human0.96201668
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96064783
127SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.93226391
128RARA_24833708_ChIP-Seq_LIVER_Mouse0.92129060
129ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91531643
130GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91399080
131STAT3_18555785_Chip-Seq_ESCs_Mouse0.90787562
132CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.90420437
133EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90359052
134NFYB_21822215_ChIP-Seq_K562_Human0.89054295
135ERG_20517297_ChIP-Seq_VCAP_Human0.88412197
136ZFX_18555785_Chip-Seq_ESCs_Mouse0.88256233
137TBL1_22424771_ChIP-Seq_293T_Human0.87743892
138CBP_21632823_ChIP-Seq_H3396_Human0.87465534
139SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87348908
140SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85994604
141GF1_26923725_Chip-Seq_HPCs_Mouse0.85833087
142GATA3_21867929_ChIP-Seq_CD8_Mouse0.84376121
143NFYA_21822215_ChIP-Seq_K562_Human0.84145058
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83990397
145CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83752125
146GATA6_21074721_ChIP-Seq_CACO-2_Human0.83506151
147NANOG_18555785_Chip-Seq_ESCs_Mouse0.83261333
148RBPJ_21746931_ChIP-Seq_IB4_Human0.83119146
149* P53_22387025_ChIP-Seq_ESCs_Mouse0.82681204
150SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82025079
151SPI1_26923725_Chip-Seq_HPCs_Mouse0.81893741
152NMYC_18555785_Chip-Seq_ESCs_Mouse0.81782948
153ETV1_20927104_ChIP-Seq_GIST48_Human0.81624453
154KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.81011400
155PU1_27457419_Chip-Seq_LIVER_Mouse0.80744339
156FOXH1_21741376_ChIP-Seq_EPCs_Human0.80616364
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80472927
158BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79991868
159SMAD1_18555785_Chip-Seq_ESCs_Mouse0.79859618
160KLF4_18555785_Chip-Seq_ESCs_Mouse0.78878459
161SOX2_18555785_Chip-Seq_ESCs_Mouse0.77903101
162RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77800547
163PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.77785684
164TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.76742327
165FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76643835
166GATA3_26560356_Chip-Seq_TH1_Human0.76616797
167RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76549940
168FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.76442157
169FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76352613
170GATA3_21867929_ChIP-Seq_TH1_Mouse0.76283496
171P53_21459846_ChIP-Seq_SAOS-2_Human0.74370292
172TAL1_26923725_Chip-Seq_HPCs_Mouse0.73901075
173* FOXA1_25552417_ChIP-Seq_VCAP_Human0.72939028
174RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.72557788

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.90036931
2MP0005360_urolithiasis6.08114687
3MP0005365_abnormal_bile_salt5.74941260
4MP0005085_abnormal_gallbladder_physiolo5.67390566
5MP0008875_abnormal_xenobiotic_pharmacok3.95046876
6MP0003252_abnormal_bile_duct3.28460750
7MP0008058_abnormal_DNA_repair3.15096794
8MP0003890_abnormal_embryonic-extraembry3.13641502
9MP0005410_abnormal_fertilization3.01376838
10MP0010329_abnormal_lipoprotein_level2.94321645
11MP0003195_calcinosis2.88002067
12MP0003806_abnormal_nucleotide_metabolis2.67531399
13MP0004957_abnormal_blastocyst_morpholog2.54781531
14MP0009840_abnormal_foam_cell2.52688318
15MP0010094_abnormal_chromosome_stability2.47658236
16MP0005451_abnormal_body_composition2.42519616
17MP0003123_paternal_imprinting2.39445803
18MP0004019_abnormal_vitamin_homeostasis2.37202147
19MP0005332_abnormal_amino_acid2.35331170
20MP0001666_abnormal_nutrient_absorption2.34892673
21MP0005083_abnormal_biliary_tract2.32273886
22MP0003868_abnormal_feces_composition2.15183064
23MP0009697_abnormal_copulation2.06429722
24MP0003646_muscle_fatigue2.06416820
25MP0003787_abnormal_imprinting2.05983435
26MP0005377_hearing/vestibular/ear_phenot2.05129632
27MP0003878_abnormal_ear_physiology2.05129632
28MP0005647_abnormal_sex_gland1.98477340
29MP0001764_abnormal_homeostasis1.94282741
30MP0000609_abnormal_liver_physiology1.93332227
31MP0003121_genomic_imprinting1.92014982
32MP0002138_abnormal_hepatobiliary_system1.91291442
33MP0002118_abnormal_lipid_homeostasis1.80819851
34MP0003077_abnormal_cell_cycle1.76419897
35MP0003941_abnormal_skin_development1.76074428
36MP0003191_abnormal_cellular_cholesterol1.69457033
37MP0005319_abnormal_enzyme/_coenzyme1.65804050
38MP0005670_abnormal_white_adipose1.55765280
39MP0008004_abnormal_stomach_pH1.53300666
40MP0003718_maternal_effect1.50713623
41MP0001929_abnormal_gametogenesis1.49356613
42MP0004147_increased_porphyrin_level1.45134124
43MP0008932_abnormal_embryonic_tissue1.43318536
44MP0003698_abnormal_male_reproductive1.38864138
45MP0010234_abnormal_vibrissa_follicle1.38447063
46MP0002163_abnormal_gland_morphology1.35448169
47MP0001529_abnormal_vocalization1.31187783
48MP0005636_abnormal_mineral_homeostasis1.26857980
49MP0008007_abnormal_cellular_replicative1.26805925
50MP0010352_gastrointestinal_tract_polyps1.25147044
51MP0009643_abnormal_urine_homeostasis1.24882770
52MP0010678_abnormal_skin_adnexa1.23113414
53MP0001697_abnormal_embryo_size1.17598168
54MP0008995_early_reproductive_senescence1.17075037
55MP0003937_abnormal_limbs/digits/tail_de1.16172658
56MP0005646_abnormal_pituitary_gland1.14379085
57MP0002210_abnormal_sex_determination1.14129615
58MP0004215_abnormal_myocardial_fiber1.14107693
59MP0002084_abnormal_developmental_patter1.14033458
60MP0005187_abnormal_penis_morphology1.13203145
61MP0004043_abnormal_pH_regulation1.11408247
62MP0001661_extended_life_span1.11406337
63MP0003656_abnormal_erythrocyte_physiolo1.09566873
64MP0006036_abnormal_mitochondrial_physio1.08732403
65MP0003186_abnormal_redox_activity1.06969293
66MP0000383_abnormal_hair_follicle1.05625159
67MP0008877_abnormal_DNA_methylation1.04610923
68MP0003122_maternal_imprinting1.04547787
69MP0002837_dystrophic_cardiac_calcinosis1.04523482
70MP0001730_embryonic_growth_arrest1.04067008
71MP0001188_hyperpigmentation1.02979285
72MP0006292_abnormal_olfactory_placode1.02128043
73MP0001672_abnormal_embryogenesis/_devel0.99881492
74MP0005380_embryogenesis_phenotype0.99881492
75MP0003879_abnormal_hair_cell0.98739551
76MP0005220_abnormal_exocrine_pancreas0.98652721
77MP0000647_abnormal_sebaceous_gland0.98258029
78MP0005666_abnormal_adipose_tissue0.98245845
79MP0004133_heterotaxia0.96971327
80MP0004270_analgesia0.96772530
81MP0003693_abnormal_embryo_hatching0.95349691
82MP0000653_abnormal_sex_gland0.91719151
83MP0002102_abnormal_ear_morphology0.91166028
84MP0010307_abnormal_tumor_latency0.91141161
85MP0005551_abnormal_eye_electrophysiolog0.90864556
86MP0002971_abnormal_brown_adipose0.89837830
87MP0000631_abnormal_neuroendocrine_gland0.88467324
88MP0002233_abnormal_nose_morphology0.87778373
89MP0005084_abnormal_gallbladder_morpholo0.87698248
90MP0001145_abnormal_male_reproductive0.87215543
91MP0000598_abnormal_liver_morphology0.86790455
92MP0003984_embryonic_growth_retardation0.86048772
93MP0002876_abnormal_thyroid_physiology0.85853954
94MP0002078_abnormal_glucose_homeostasis0.85390370
95MP0001293_anophthalmia0.85313383
96MP0002088_abnormal_embryonic_growth/wei0.85043166
97MP0005584_abnormal_enzyme/coenzyme_acti0.84942129
98MP0005395_other_phenotype0.84685400
99MP0009764_decreased_sensitivity_to0.84589013
100MP0001485_abnormal_pinna_reflex0.84176280
101MP0002161_abnormal_fertility/fecundity0.83882482
102MP0002132_abnormal_respiratory_system0.82961921
103MP0002085_abnormal_embryonic_tissue0.81041601
104MP0009780_abnormal_chondrocyte_physiolo0.80420579
105MP0008260_abnormal_autophagy0.79874450
106MP0005408_hypopigmentation0.79798574
107MP0009703_decreased_birth_body0.78069960
108MP0000358_abnormal_cell_content/0.77585883
109MP0001765_abnormal_ion_homeostasis0.76411540
110MP0004185_abnormal_adipocyte_glucose0.74510472
111MP0005334_abnormal_fat_pad0.74361628
112MP0004197_abnormal_fetal_growth/weight/0.73595635
113MP0001984_abnormal_olfaction0.73536396
114MP0009642_abnormal_blood_homeostasis0.73214118
115MP0001944_abnormal_pancreas_morphology0.72552576
116MP0004782_abnormal_surfactant_physiolog0.72152478
117MP0002090_abnormal_vision0.71752820
118MP0008872_abnormal_physiological_respon0.71665290
119MP0001756_abnormal_urination0.71198895
120MP0001286_abnormal_eye_development0.71130668
121MP0009046_muscle_twitch0.70735018
122MP0000350_abnormal_cell_proliferation0.69012206
123MP0002086_abnormal_extraembryonic_tissu0.67737048
124MP0004130_abnormal_muscle_cell0.67018986
125MP0001881_abnormal_mammary_gland0.66973705
126MP0008469_abnormal_protein_level0.65502025
127MP0001119_abnormal_female_reproductive0.62374940
128MP0004264_abnormal_extraembryonic_tissu0.61885367
129MP0009763_increased_sensitivity_to0.61561024
130MP0003699_abnormal_female_reproductive0.60896657
131MP0002928_abnormal_bile_duct0.60841058
132MP0000566_synostosis0.58368228
133MP0006035_abnormal_mitochondrial_morpho0.57415708
134MP0003786_premature_aging0.56955011
135MP0005535_abnormal_body_temperature0.55804169
136MP0002136_abnormal_kidney_physiology0.55614823
137MP0005376_homeostasis/metabolism_phenot0.55604144
138MP0009115_abnormal_fat_cell0.55025973
139MP0005389_reproductive_system_phenotype0.54960689
140MP0002796_impaired_skin_barrier0.53866675
141MP0005379_endocrine/exocrine_gland_phen0.51936970
142MP0003953_abnormal_hormone_level0.51239982
143MP0000579_abnormal_nail_morphology0.49550623
144MP0002254_reproductive_system_inflammat0.49429540
145MP0009672_abnormal_birth_weight0.49424045
146MP0008057_abnormal_DNA_replication0.48767286
147MP0000678_abnormal_parathyroid_gland0.48223947
148MP0002160_abnormal_reproductive_system0.47442107
149MP0002693_abnormal_pancreas_physiology0.47424310
150MP0005448_abnormal_energy_balance0.45785168
151MP0003221_abnormal_cardiomyocyte_apopto0.45284554
152MP0005266_abnormal_metabolism0.44482392
153MP0003011_delayed_dark_adaptation0.43398366
154MP0005330_cardiomyopathy0.43276551
155MP0003111_abnormal_nucleus_morphology0.43147042

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)5.31950250
2Intrahepatic cholestasis (HP:0001406)5.19813301
3Absent/shortened dynein arms (HP:0200106)4.96506774
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.96506774
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.92600625
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.83683630
7Prolonged partial thromboplastin time (HP:0003645)4.72735073
8Hyperglycinuria (HP:0003108)4.65965621
9Abnormality of monocarboxylic acid metabolism (HP:0010996)4.62985621
10Deep venous thrombosis (HP:0002625)4.56813294
11Hypobetalipoproteinemia (HP:0003563)4.39033905
12Xanthomatosis (HP:0000991)4.31932052
13Abnormality of glycine metabolism (HP:0010895)4.21876152
14Abnormality of serine family amino acid metabolism (HP:0010894)4.21876152
15Conjugated hyperbilirubinemia (HP:0002908)3.66230246
16Hypolipoproteinemia (HP:0010981)3.64747159
17Hyperammonemia (HP:0001987)3.63935128
18Complement deficiency (HP:0004431)3.60867280
19Hyperlipoproteinemia (HP:0010980)3.60644791
20Abnormal respiratory motile cilium physiology (HP:0012261)3.58861178
21Joint hemorrhage (HP:0005261)3.49444560
22Papillary thyroid carcinoma (HP:0002895)3.48993100
23Hypoalphalipoproteinemia (HP:0003233)3.45989072
24Abnormality of serum amino acid levels (HP:0003112)3.43527057
25Hypoglycemic coma (HP:0001325)3.38825803
26Abnormal respiratory epithelium morphology (HP:0012253)3.38313173
27Abnormal respiratory motile cilium morphology (HP:0005938)3.38313173
28Alopecia of scalp (HP:0002293)3.37990629
29Rhinitis (HP:0012384)3.36157916
30Ketosis (HP:0001946)3.29525136
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.25310184
32Fat malabsorption (HP:0002630)3.24306365
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.23604588
34Chromsome breakage (HP:0040012)3.19980631
35Gout (HP:0001997)3.19578072
36Abnormality of glutamine family amino acid metabolism (HP:0010902)3.15702896
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.14966246
38Epidermoid cyst (HP:0200040)3.14652773
39Abnormality of the labia minora (HP:0012880)3.12265733
40Abnormality of the intrinsic pathway (HP:0010989)3.05781441
41Abnormality of pyrimidine metabolism (HP:0004353)3.02249013
42Abnormality of methionine metabolism (HP:0010901)3.01018256
43Volvulus (HP:0002580)3.00499949
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98169861
45Abnormality of fatty-acid metabolism (HP:0004359)2.95366841
46Azoospermia (HP:0000027)2.95205621
47Abnormality of nucleobase metabolism (HP:0010932)2.94407243
48Abnormality of purine metabolism (HP:0004352)2.90486358
49Abnormality of the common coagulation pathway (HP:0010990)2.86390478
50Increased serum pyruvate (HP:0003542)2.84270500
51Abnormal ciliary motility (HP:0012262)2.84150669
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81549470
53Abnormality of alanine metabolism (HP:0010916)2.81549470
54Hyperalaninemia (HP:0003348)2.81549470
55Hepatoblastoma (HP:0002884)2.78998753
56Abnormal spermatogenesis (HP:0008669)2.78388287
57Chronic bronchitis (HP:0004469)2.72971016
58Spontaneous abortion (HP:0005268)2.65970545
59Acanthocytosis (HP:0001927)2.65774221
60Abnormality of chromosome stability (HP:0003220)2.62563383
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.62182024
62Vascular calcification (HP:0004934)2.61812299
63Myocardial infarction (HP:0001658)2.58900844
64Double outlet right ventricle (HP:0001719)2.58217700
65Congenital malformation of the right heart (HP:0011723)2.58217700
66Metabolic acidosis (HP:0001942)2.57615630
67Hypercholesterolemia (HP:0003124)2.56683848
68Dicarboxylic aciduria (HP:0003215)2.56287210
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56287210
70Abnormal pancreas size (HP:0012094)2.54949120
71Hyperglycemia (HP:0003074)2.54494245
72Impulsivity (HP:0100710)2.52562062
73Unilateral renal agenesis (HP:0000122)2.52110424
74Abnormality of glycolysis (HP:0004366)2.49334897
75Abnormality of complement system (HP:0005339)2.47954817
76Renal cortical cysts (HP:0000803)2.47710694
77Lethargy (HP:0001254)2.44911220
78Infertility (HP:0000789)2.44871997
79Increased purine levels (HP:0004368)2.44152870
80Hyperuricemia (HP:0002149)2.44152870
81Pancreatic islet-cell hyperplasia (HP:0004510)2.40618210
82Aplasia/Hypoplasia of the uvula (HP:0010293)2.39777505
83Hypoglycemic seizures (HP:0002173)2.39674549
84Increased hepatocellular lipid droplets (HP:0006565)2.36118550
85Hyperbilirubinemia (HP:0002904)2.35986672
86Meckel diverticulum (HP:0002245)2.35976406
87Colon cancer (HP:0003003)2.35479912
88Embryonal renal neoplasm (HP:0011794)2.35467207
89Thyroid carcinoma (HP:0002890)2.33500264
90Nephroblastoma (Wilms tumor) (HP:0002667)2.33396695
91Abnormality of the ileum (HP:0001549)2.30359794
92Ketoacidosis (HP:0001993)2.29176972
93Steatorrhea (HP:0002570)2.28504229
94Hypoplasia of the pons (HP:0012110)2.27177602
95Generalized aminoaciduria (HP:0002909)2.26668646
96Medial flaring of the eyebrow (HP:0010747)2.24581692
97Fair hair (HP:0002286)2.23808727
98Cardiovascular calcification (HP:0011915)2.23253026
99Nausea (HP:0002018)2.23250408
100Intestinal atresia (HP:0011100)2.22251174
101Atrioventricular block (HP:0001678)2.22129413
102Poikilocytosis (HP:0004447)2.21413737
103Neoplasm of the adrenal cortex (HP:0100641)2.19577584
104Rhabdomyosarcoma (HP:0002859)2.19448208
105Abnormality of the pons (HP:0007361)2.19231769
106Lipid accumulation in hepatocytes (HP:0006561)2.18488861
107Abnormality of the duodenum (HP:0002246)2.17320523
108Hyperinsulinemic hypoglycemia (HP:0000825)2.16081488
109Male infertility (HP:0003251)2.15849696
110Small intestinal stenosis (HP:0012848)2.15209103
111Duodenal stenosis (HP:0100867)2.15209103
112Cerebral edema (HP:0002181)2.14087681
113Parakeratosis (HP:0001036)2.13489067
114Increased CSF lactate (HP:0002490)2.12807449
115Abnormality of the renal cortex (HP:0011035)2.11126187
116Abnormality of the preputium (HP:0100587)2.08631391
117Chronic hepatic failure (HP:0100626)2.06187326
118Hepatocellular carcinoma (HP:0001402)2.05501153
119Biliary tract neoplasm (HP:0100574)2.02637178
120Proximal tubulopathy (HP:0000114)2.01800033
121Acute necrotizing encephalopathy (HP:0006965)2.01572201
122Acute encephalopathy (HP:0006846)2.00958340
123Birth length less than 3rd percentile (HP:0003561)2.00323599
124Bile duct proliferation (HP:0001408)1.97595160
125Abnormal biliary tract physiology (HP:0012439)1.97595160
126Sloping forehead (HP:0000340)1.97357118
127Gaze-evoked nystagmus (HP:0000640)1.96023729
128Abnormal biliary tract morphology (HP:0012440)1.95873499
129Microvesicular hepatic steatosis (HP:0001414)1.94398806
130Pancreatitis (HP:0001733)1.91680810
131Nasal polyposis (HP:0100582)1.91003425
132Neoplasm of the adrenal gland (HP:0100631)1.89367014
133Malnutrition (HP:0004395)1.87862733
134Poor coordination (HP:0002370)1.87692184
135Hypophosphatemic rickets (HP:0004912)1.87336967
136Renal Fanconi syndrome (HP:0001994)1.86046246
137Bilateral sensorineural hearing impairment (HP:0008619)1.85183477
138Ependymoma (HP:0002888)1.84407522
139Polycythemia (HP:0001901)1.84015578
140Absent eyebrow (HP:0002223)1.83711605
141Heart block (HP:0012722)1.83347178
142Hypochromic microcytic anemia (HP:0004840)1.83181815
143Labial hypoplasia (HP:0000066)1.82959824
144Acute myeloid leukemia (HP:0004808)1.82867024
145Recurrent gram-negative bacterial infections (HP:0005420)1.82764930
146Symptomatic seizures (HP:0011145)1.81225154
147Ileus (HP:0002595)1.81082591
148Insulin-resistant diabetes mellitus (HP:0000831)1.80938121
149Oligodactyly (hands) (HP:0001180)1.80693311
150Hypoplastic labia majora (HP:0000059)1.80435253
151Congenital primary aphakia (HP:0007707)1.79378922
152Aplasia/Hypoplasia of the tibia (HP:0005772)1.79066937
153Bronchiectasis (HP:0002110)1.77637251
154Tubulointerstitial nephritis (HP:0001970)1.77237628
155Glycosuria (HP:0003076)1.76571287
156Abnormality of urine glucose concentration (HP:0011016)1.76571287
157Abnormal lung lobation (HP:0002101)1.76557907
158Irritability (HP:0000737)1.75396453
159Enlarged kidneys (HP:0000105)1.74769172
160Progressive macrocephaly (HP:0004481)1.74664782
161Hypoplastic female external genitalia (HP:0012815)1.73463926
162Mitochondrial inheritance (HP:0001427)1.73128759
163Hypothermia (HP:0002045)1.71370552
164Absent radius (HP:0003974)1.71343474
165Molar tooth sign on MRI (HP:0002419)1.71120472
166Abnormality of midbrain morphology (HP:0002418)1.71120472
167Myelodysplasia (HP:0002863)1.70983077
168Abnormality of renal resorption (HP:0011038)1.68987776
169Gait imbalance (HP:0002141)1.68930863
170Genital tract atresia (HP:0001827)1.68029394
171Abnormality of the pancreatic islet cells (HP:0006476)1.65241604
172Abnormality of endocrine pancreas physiology (HP:0012093)1.65241604
173Supernumerary spleens (HP:0009799)1.64856902
174Astrocytoma (HP:0009592)1.63730428
175Abnormality of the astrocytes (HP:0100707)1.63730428
176Neoplasm of the small intestine (HP:0100833)1.61979011
177Vaginal atresia (HP:0000148)1.59696049
178Median cleft lip (HP:0000161)1.59647269
179Abnormality of the labia majora (HP:0012881)1.59275968
180Osteomalacia (HP:0002749)1.58916225
181Gastrointestinal atresia (HP:0002589)1.56865036

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.39964865
2PDK35.39964865
3STK38L4.06669398
4PDK23.87585667
5LATS13.67518009
6MST43.38156355
7BCKDK2.91683536
8SIK12.87617836
9NEK12.83625230
10TNIK2.49587895
11TAOK32.40700840
12FRK2.30482227
13CDC72.27028608
14BMPR1B2.26769530
15STK32.18424986
16PBK2.17375954
17NEK22.08153280
18LATS21.98678776
19CCNB11.93230574
20INSRR1.92858972
21MAP4K21.92348012
22BUB11.87875282
23PLK31.86343553
24MARK31.83252994
25SIK31.75763076
26STK381.73805028
27MKNK11.72020677
28PNCK1.71681683
29PINK11.69521287
30CAMK1G1.68897578
31MAP3K41.67007748
32IRAK31.64033008
33FGFR41.55480265
34TSSK61.54661706
35TAF11.40311503
36AKT31.38811159
37CAMK1D1.37116929
38BRD41.34166813
39PRKAA11.31489430
40ZAK1.30127555
41PLK21.29423612
42ERBB41.28479308
43WNK41.26626479
44MAPK111.22754232
45MAP3K31.22579533
46OBSCN1.20636773
47EPHA21.18018584
48DYRK31.14473733
49MST1R1.13831828
50TRIM281.12470416
51PIK3CG1.09598166
52PLK41.08792076
53WNK31.08673683
54EIF2AK11.06740527
55VRK11.05556556
56TTK1.05221182
57NUAK11.04290887
58PRKAA21.01336703
59STK161.00430548
60SIK20.95519149
61PRKD30.95356725
62MAP3K50.91658061
63ERBB30.91068307
64NME20.89128852
65ABL20.88181488
66OXSR10.87978393
67BRSK20.86627729
68NEK90.86218240
69CSNK1G10.85226397
70NLK0.84556893
71CDK40.83777347
72CAMKK20.82797077
73CDK80.77826260
74SRPK10.76463152
75ACVR1B0.76347802
76SGK20.75811192
77CSNK1E0.73367392
78TYK20.70117090
79STK390.69284701
80MUSK0.69000764
81ATR0.64154856
82CHEK20.63785882
83CASK0.63627619
84MET0.63594619
85PHKG20.63586927
86PHKG10.63586927
87CDK30.63504137
88BRSK10.62511003
89MAP2K40.62120382
90STK240.61399957
91VRK20.61099047
92MAP3K90.60269972
93FGFR10.59045505
94AURKB0.57614104
95BCR0.55244078
96IRAK10.53867548
97ERN10.52058193
98IRAK20.52010189
99MAP3K60.51883094
100SGK30.50005327
101NTRK30.49980384
102CDK10.48980529
103RPS6KB20.48331269
104PLK10.48061074
105RPS6KA40.47530366
106TEC0.47331552
107MAP2K30.44931679
108LMTK20.44693259
109TGFBR10.44450513
110CDK120.44090611
111CSNK2A20.43844199
112MAP3K20.43512267
113JAK10.43439154
114EIF2AK20.42890998
115PRKCE0.42225031
116JAK20.42116738
117SCYL20.41398194
118MAPKAPK30.41043849
119PDK10.40608217
120WEE10.40549285
121PRKCG0.40388248
122PIM10.39200632
123MKNK20.39136432
124CSNK1G20.39011144
125WNK10.38860657
126PRKACB0.38597927
127CDK20.38498439
128MAPK150.38325444
129MAP2K60.38103681
130TLK10.37978029
131STK40.37183964
132PAK30.35733848
133PIK3CA0.34981938
134MAP3K140.34749770
135MAP2K20.34648404
136EIF2AK30.34437736
137PRKG10.34234441
138CHEK10.33950494
139MAP3K120.33275922
140CSNK2A10.33160533
141TAOK20.31449469
142GSK3A0.30018319
143MTOR0.29778411
144TIE10.28824790
145CDK70.28732329
146TRIB30.28321034
147CDK90.27670748
148ATM0.27217507
149NME10.26290474
150PDPK10.25495492
151GRK10.25444355
152EPHA30.25229934
153PRKACG0.24363329
154TXK0.23391507
155MELK0.23197540
156BRAF0.21666746

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.60998683
2Vitamin B6 metabolism_Homo sapiens_hsa007503.34322054
3Protein export_Homo sapiens_hsa030602.97941715
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.83020348
5Arginine biosynthesis_Homo sapiens_hsa002202.69187001
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.58516293
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.50021807
8Fatty acid degradation_Homo sapiens_hsa000712.47046729
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45903046
10Nitrogen metabolism_Homo sapiens_hsa009102.45318014
11Mismatch repair_Homo sapiens_hsa034302.44319970
12Tryptophan metabolism_Homo sapiens_hsa003802.40959494
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.35615705
14Propanoate metabolism_Homo sapiens_hsa006402.31579148
15Complement and coagulation cascades_Homo sapiens_hsa046102.23900653
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.17238300
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.16395427
18Homologous recombination_Homo sapiens_hsa034402.02142591
19Peroxisome_Homo sapiens_hsa041461.94446472
20PPAR signaling pathway_Homo sapiens_hsa033201.94432526
21Non-homologous end-joining_Homo sapiens_hsa034501.93991210
22Selenocompound metabolism_Homo sapiens_hsa004501.93525424
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91559665
24Butanoate metabolism_Homo sapiens_hsa006501.91438716
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91121233
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.89160460
27Chemical carcinogenesis_Homo sapiens_hsa052041.79895001
28beta-Alanine metabolism_Homo sapiens_hsa004101.78768950
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77412174
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.76924600
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.74436640
32DNA replication_Homo sapiens_hsa030301.70890286
33Fatty acid metabolism_Homo sapiens_hsa012121.66483131
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.65556289
35Histidine metabolism_Homo sapiens_hsa003401.62396169
36Retinol metabolism_Homo sapiens_hsa008301.62263788
37Nucleotide excision repair_Homo sapiens_hsa034201.61794695
38Vitamin digestion and absorption_Homo sapiens_hsa049771.61769865
39RNA degradation_Homo sapiens_hsa030181.57748740
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52829527
41Pyruvate metabolism_Homo sapiens_hsa006201.52411080
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.51702896
43Fat digestion and absorption_Homo sapiens_hsa049751.50347891
44Folate biosynthesis_Homo sapiens_hsa007901.45824826
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.43138964
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42856324
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.41582463
48Starch and sucrose metabolism_Homo sapiens_hsa005001.40668912
49Sulfur metabolism_Homo sapiens_hsa009201.39297309
50Base excision repair_Homo sapiens_hsa034101.37015276
51Staphylococcus aureus infection_Homo sapiens_hsa051501.35318746
52Caffeine metabolism_Homo sapiens_hsa002321.32307402
53Cell cycle_Homo sapiens_hsa041101.30354873
54ABC transporters_Homo sapiens_hsa020101.27397995
55Arginine and proline metabolism_Homo sapiens_hsa003301.21105266
56Carbon metabolism_Homo sapiens_hsa012001.20583239
57Phenylalanine metabolism_Homo sapiens_hsa003601.19173742
58Pentose phosphate pathway_Homo sapiens_hsa000301.16920165
59mRNA surveillance pathway_Homo sapiens_hsa030151.16850626
60Bile secretion_Homo sapiens_hsa049761.12826672
61Biosynthesis of amino acids_Homo sapiens_hsa012301.11853251
62Spliceosome_Homo sapiens_hsa030401.11045301
63Glycerolipid metabolism_Homo sapiens_hsa005611.08103708
64Oxidative phosphorylation_Homo sapiens_hsa001901.06557230
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04316195
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03660483
67Tyrosine metabolism_Homo sapiens_hsa003501.02806685
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00666176
69Sulfur relay system_Homo sapiens_hsa041220.98764405
70Oocyte meiosis_Homo sapiens_hsa041140.98717750
71Proteasome_Homo sapiens_hsa030500.96294775
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94358665
73Parkinsons disease_Homo sapiens_hsa050120.93231604
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92675463
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90977769
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90409923
77Linoleic acid metabolism_Homo sapiens_hsa005910.89075308
78Fatty acid biosynthesis_Homo sapiens_hsa000610.89050419
79Lysine degradation_Homo sapiens_hsa003100.88641750
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86279208
81Huntingtons disease_Homo sapiens_hsa050160.85213767
82Fatty acid elongation_Homo sapiens_hsa000620.84531552
83Steroid biosynthesis_Homo sapiens_hsa001000.83405681
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79672748
85Glutathione metabolism_Homo sapiens_hsa004800.79398847
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.72402884
87p53 signaling pathway_Homo sapiens_hsa041150.71379986
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.68739629
89Fructose and mannose metabolism_Homo sapiens_hsa000510.65525912
90Metabolic pathways_Homo sapiens_hsa011000.64965933
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63201707
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61841019
93Pancreatic secretion_Homo sapiens_hsa049720.61677220
94Basal transcription factors_Homo sapiens_hsa030220.60930567
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55855790
96Regulation of autophagy_Homo sapiens_hsa041400.54937647
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52918115
98Glucagon signaling pathway_Homo sapiens_hsa049220.48409373
99Ribosome_Homo sapiens_hsa030100.48402140
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45943079
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43563487
102One carbon pool by folate_Homo sapiens_hsa006700.41254074
103Insulin resistance_Homo sapiens_hsa049310.40391370
104Mineral absorption_Homo sapiens_hsa049780.40300105
105Circadian rhythm_Homo sapiens_hsa047100.40213605
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39137687
107Phototransduction_Homo sapiens_hsa047440.38207187
108Alzheimers disease_Homo sapiens_hsa050100.37639688
109Arachidonic acid metabolism_Homo sapiens_hsa005900.36818084
110Fanconi anemia pathway_Homo sapiens_hsa034600.36119156
111Galactose metabolism_Homo sapiens_hsa000520.35550247
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.33827710
113RNA polymerase_Homo sapiens_hsa030200.32644057
114Pyrimidine metabolism_Homo sapiens_hsa002400.30377454
115Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.29472587
116AMPK signaling pathway_Homo sapiens_hsa041520.22253555
117Purine metabolism_Homo sapiens_hsa002300.20268297
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18676734
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16817354
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.08436066
121Ovarian steroidogenesis_Homo sapiens_hsa049130.05790732
122Dorso-ventral axis formation_Homo sapiens_hsa043200.04271800
123RNA transport_Homo sapiens_hsa030130.01938225
124Renin-angiotensin system_Homo sapiens_hsa04614-0.0636771
125Insulin signaling pathway_Homo sapiens_hsa04910-0.0590612
126Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0334028
127Sphingolipid metabolism_Homo sapiens_hsa00600-0.0259200
128Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0216365
129Ether lipid metabolism_Homo sapiens_hsa00565-0.0145876

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