LARP1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfate transmembrane transport (GO:1902358)6.80558326
2sterol catabolic process (GO:0016127)6.49727474
3cholesterol catabolic process (GO:0006707)6.49727474
4cerebral cortex radially oriented cell migration (GO:0021799)6.23693538
5mRNA modification (GO:0016556)6.01512821
6sulfate transport (GO:0008272)5.79900737
7acrosome assembly (GO:0001675)5.64387156
8cytidine deamination (GO:0009972)5.13934694
9cytidine metabolic process (GO:0046087)5.13934694
10cytidine catabolic process (GO:0006216)5.13934694
11entrainment of circadian clock by photoperiod (GO:0043153)5.09497061
12melanocyte differentiation (GO:0030318)5.05973722
13regulation of cholesterol homeostasis (GO:2000188)5.05797181
14regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.97440510
15entrainment of circadian clock (GO:0009649)4.92770660
16protein polyglutamylation (GO:0018095)4.78492316
17pigment cell differentiation (GO:0050931)4.58800069
18pyrimidine ribonucleoside catabolic process (GO:0046133)4.48294617
19virion assembly (GO:0019068)4.45812300
20lipoprotein transport (GO:0042953)4.43257032
21tRNA methylation (GO:0030488)4.39215178
22regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.32731736
23mucosal-associated lymphoid tissue development (GO:0048537)4.25014153
24Peyers patch development (GO:0048541)4.25014153
25regulation of megakaryocyte differentiation (GO:0045652)4.23216812
26regulation of synapse maturation (GO:0090128)4.19348727
27viral protein processing (GO:0019082)4.17458934
28negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.09445577
29COPII vesicle coating (GO:0048208)4.07651862
30positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc4.05565747
31positive regulation of extracellular matrix organization (GO:1903055)3.99050486
32detection of light stimulus involved in visual perception (GO:0050908)3.96883898
33detection of light stimulus involved in sensory perception (GO:0050962)3.96883898
34keratinocyte development (GO:0003334)3.95960323
35DNA replication-dependent nucleosome assembly (GO:0006335)3.95770645
36DNA replication-dependent nucleosome organization (GO:0034723)3.95770645
37TOR signaling (GO:0031929)3.95239138
38photoperiodism (GO:0009648)3.86880139
39somite development (GO:0061053)3.83757518
40regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.83025810
41positive regulation of astrocyte differentiation (GO:0048711)3.74583000
42positive regulation of mitochondrial membrane permeability (GO:0035794)3.74420624
43positive regulation of erythrocyte differentiation (GO:0045648)3.73730318
44base-excision repair, AP site formation (GO:0006285)3.71604000
45mammary gland epithelial cell proliferation (GO:0033598)3.69553408
46negative regulation of oligodendrocyte differentiation (GO:0048715)3.69269639
47positive regulation of action potential (GO:0045760)3.64367059
48base-excision repair (GO:0006284)3.63694154
49mitochondrial calcium ion homeostasis (GO:0051560)3.62420780
50DNA demethylation (GO:0080111)3.54278092
51mitochondrial genome maintenance (GO:0000002)3.52848832
52positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.46237493
53stress granule assembly (GO:0034063)3.45457501
54response to nerve growth factor (GO:1990089)3.44946518
55cellular response to nerve growth factor stimulus (GO:1990090)3.44946518
56negative regulation of keratinocyte proliferation (GO:0010839)3.44613976
57protein K6-linked ubiquitination (GO:0085020)3.44530899
58DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.44046075
59embryonic digestive tract morphogenesis (GO:0048557)3.40904935
60neuroepithelial cell differentiation (GO:0060563)3.36997584
61positive regulation of stem cell differentiation (GO:2000738)3.36832575
62negative regulation of stress fiber assembly (GO:0051497)3.33433242
63steroid catabolic process (GO:0006706)3.32672611
64negative regulation of dendrite development (GO:2000171)3.31267055
65regulation of gene silencing (GO:0060968)3.29099465
66mitochondrial DNA metabolic process (GO:0032042)3.25757646
67mitochondrial DNA replication (GO:0006264)3.25038925
68positive regulation of neuroblast proliferation (GO:0002052)3.25019052
69long term synaptic depression (GO:0060292)3.23737586
70regulation of metalloenzyme activity (GO:0048552)3.22909429
71ear development (GO:0043583)3.12162187
72positive regulation of protein homooligomerization (GO:0032464)3.10378827
73regulation of clathrin-mediated endocytosis (GO:2000369)3.09346614
74regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.08639436
75negative regulation of gene silencing (GO:0060969)3.06177658
76adult feeding behavior (GO:0008343)3.05170642
77detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.04856538
78regulation of hematopoietic progenitor cell differentiation (GO:1901532)3.03606906
79fibroblast migration (GO:0010761)3.01635983
80dopamine transport (GO:0015872)2.98204548
81establishment of protein localization to Golgi (GO:0072600)2.97796976
82cellular response to reactive nitrogen species (GO:1902170)2.96715880
83sulfur compound transport (GO:0072348)2.95349696
84positive regulation of histone deacetylation (GO:0031065)2.94434329
85positive regulation of megakaryocyte differentiation (GO:0045654)2.93686364
86DNA damage response, signal transduction resulting in transcription (GO:0042772)2.93001021
87negative regulation of mRNA processing (GO:0050686)2.90547247
88regulation of cilium movement (GO:0003352)2.90513559
89regulation of histone deacetylation (GO:0031063)2.86161849
90cell proliferation in forebrain (GO:0021846)2.86034137
91positive regulation of calcium ion import (GO:0090280)2.83301707
92response to gravity (GO:0009629)2.82643469
93regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.79848570
94natural killer cell differentiation (GO:0001779)2.78606109
95histone deubiquitination (GO:0016578)2.78179097
96negative regulation of DNA recombination (GO:0045910)2.76508815
97mRNA splice site selection (GO:0006376)2.75741090
98mesenchymal cell differentiation involved in renal system development (GO:2001012)2.75006224
99mesenchymal cell differentiation involved in kidney development (GO:0072161)2.75006224
100hematopoietic stem cell differentiation (GO:0060218)12.0278066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse7.46483739
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse7.24082392
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.01935423
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.16034382
5ESR1_15608294_ChIP-ChIP_MCF-7_Human3.56397180
6ESR1_20079471_ChIP-ChIP_T-47D_Human3.41396150
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.15025413
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.15025413
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.15025413
10DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.05134668
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.63731363
12ZNF274_21170338_ChIP-Seq_K562_Hela2.62755891
13IGF1R_20145208_ChIP-Seq_DFB_Human2.50006177
14ELK4_26923725_Chip-Seq_MESODERM_Mouse2.39042966
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse11.1677606
16SCL_19346495_ChIP-Seq_HPC-7_Human1.87057955
17TP63_19390658_ChIP-ChIP_HaCaT_Human1.65786318
18CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.49290788
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46074728
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36073058
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.32652659
22DROSHA_22980978_ChIP-Seq_HELA_Human1.32290739
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.31389164
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29459346
25VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.27749272
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25401956
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24320786
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23371316
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22810170
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19184407
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17362330
32PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13812897
33IRF1_19129219_ChIP-ChIP_H3396_Human1.13216214
34ETS1_22383799_ChIP-Seq_G1ME_Mouse1.10616147
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07502339
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05886769
37AHR_22903824_ChIP-Seq_MCF-7_Human1.04636253
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02307861
39ERG_20517297_ChIP-Seq_VCAP_Human1.02065561
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00754797
41FOXA1_25552417_ChIP-Seq_VCAP_Human0.97806588
42GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96935787
43GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94662090
44TDRD3_21172665_ChIP-Seq_MCF-7_Human0.92895486
45CIITA_25753668_ChIP-Seq_RAJI_Human0.92468091
46GATA3_21878914_ChIP-Seq_MCF-7_Human0.91071141
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89910910
48HOXB7_26014856_ChIP-Seq_BT474_Human0.89081706
49GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88262048
50ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87560360
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87485452
52GATA3_24758297_ChIP-Seq_MCF-7_Human0.87434963
53E2F1_20622854_ChIP-Seq_HELA_Human0.86524591
54E2F1_21310950_ChIP-Seq_MCF-7_Human0.85562339
55RARB_24833708_ChIP-Seq_LIVER_Mouse0.85453776
56YY1_21170310_ChIP-Seq_MESCs_Mouse0.85201595
57BRD4_25478319_ChIP-Seq_HGPS_Human0.85019375
58VDR_23849224_ChIP-Seq_CD4+_Human0.84247474
59ER_23166858_ChIP-Seq_MCF-7_Human0.82374283
60EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82016752
61MYC_22102868_ChIP-Seq_BL_Human0.80013122
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79807192
63SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79256511
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78574506
65RUNX1_27514584_Chip-Seq_MCF-7_Human0.78041261
66FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76468782
67FOXM1_26456572_ChIP-Seq_MCF-7_Human0.75467841
68CEBPB_22108803_ChIP-Seq_LS180_Human0.74611457
69RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.72554970
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72430084
71FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.72178199
72PHF8_20622854_ChIP-Seq_HELA_Human0.71484531
73P53_21459846_ChIP-Seq_SAOS-2_Human0.69196199
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.68259757
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.67087955
76TP53_22573176_ChIP-Seq_HFKS_Human0.65680934
77CDX2_19796622_ChIP-Seq_MESCs_Mouse0.65172427
78STAT3_23295773_ChIP-Seq_U87_Human0.64529703
79BCL6_27268052_Chip-Seq_Bcells_Human0.64449064
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64433155
81SALL4_22934838_ChIP-ChIP_CD34+_Human0.63876371
82SOX2_16153702_ChIP-ChIP_HESCs_Human0.63828841
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.61766563
84LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.61760630
85P300_19829295_ChIP-Seq_ESCs_Human0.61502328
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.61442017
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.60502118
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.59529576
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.59469921
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.59259191
91JUN_21703547_ChIP-Seq_K562_Human0.59103375
92CTCF_20526341_ChIP-Seq_ESCs_Human0.58781464
93BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.58729818
94FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.58604696
95ETV1_20927104_ChIP-Seq_GIST48_Human0.57840652
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57390056
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.56329145
98DPY_21335234_ChIP-Seq_ESCs_Mouse0.56100237
99SOX2_19829295_ChIP-Seq_ESCs_Human0.56048689
100NANOG_19829295_ChIP-Seq_ESCs_Human0.56048689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH9.44716949
2MP0000003_abnormal_adipose_tissue6.08162960
3MP0001502_abnormal_circadian_rhythm3.07386219
4MP0002933_joint_inflammation2.74920624
5MP0008961_abnormal_basal_metabolism2.55743371
6MP0005375_adipose_tissue_phenotype2.41353425
7MP0003195_calcinosis2.22525060
8MP0001986_abnormal_taste_sensitivity2.07671673
9MP0000371_diluted_coat_color2.02162435
10MP0000013_abnormal_adipose_tissue10.2034706
11MP0005076_abnormal_cell_differentiation1.86759585
12MP0008260_abnormal_autophagy1.82533586
13MP0009278_abnormal_bone_marrow1.78593407
14MP0001984_abnormal_olfaction1.70944330
15MP0004233_abnormal_muscle_weight1.69139645
16MP0002736_abnormal_nociception_after1.58249626
17MP0009250_abnormal_appendicular_skeleto1.54609974
18MP0002138_abnormal_hepatobiliary_system1.49229111
19MP0004484_altered_response_of1.40790145
20MP0010307_abnormal_tumor_latency1.40719608
21MP0003221_abnormal_cardiomyocyte_apopto1.35694504
22MP0001968_abnormal_touch/_nociception1.34419701
23MP0005551_abnormal_eye_electrophysiolog1.33159686
24MP0000470_abnormal_stomach_morphology1.30093603
25MP0008875_abnormal_xenobiotic_pharmacok1.27734402
26MP0004885_abnormal_endolymph1.25233737
27MP0002896_abnormal_bone_mineralization1.23028854
28MP0005646_abnormal_pituitary_gland1.14231339
29MP0006054_spinal_hemorrhage1.12996088
30MP0000516_abnormal_urinary_system1.11966615
31MP0005367_renal/urinary_system_phenotyp1.11966615
32MP0002166_altered_tumor_susceptibility1.06736196
33MP0009115_abnormal_fat_cell1.06410474
34MP0003959_abnormal_lean_body1.06350179
35MP0001501_abnormal_sleep_pattern1.06221939
36MP0004742_abnormal_vestibular_system1.05749984
37MP0005410_abnormal_fertilization1.05188595
38MP0002282_abnormal_trachea_morphology1.03855541
39MP0003786_premature_aging1.01285152
40MP0008995_early_reproductive_senescence0.99999529
41MP0004808_abnormal_hematopoietic_stem0.96616429
42MP0010329_abnormal_lipoprotein_level0.95235499
43MP0000538_abnormal_urinary_bladder0.93197600
44MP0004147_increased_porphyrin_level0.91583267
45MP0005334_abnormal_fat_pad0.89760829
46MP0001929_abnormal_gametogenesis0.88094029
47MP0003172_abnormal_lysosome_physiology0.85253675
48MP0005360_urolithiasis0.82858660
49MP0002210_abnormal_sex_determination0.81417007
50MP0000627_abnormal_mammary_gland0.81242913
51MP0005452_abnormal_adipose_tissue0.80210412
52MP0003698_abnormal_male_reproductive0.79846875
53MP0004145_abnormal_muscle_electrophysio0.79283937
54MP0003948_abnormal_gas_homeostasis0.77828338
55MP0001545_abnormal_hematopoietic_system0.77006490
56MP0005397_hematopoietic_system_phenotyp0.77006490
57MP0000767_abnormal_smooth_muscle0.75640029
58MP0005253_abnormal_eye_physiology0.74836144
59MP0001186_pigmentation_phenotype0.74764068
60MP0001664_abnormal_digestion0.74154323
61MP0001944_abnormal_pancreas_morphology0.73915592
62MP0002075_abnormal_coat/hair_pigmentati0.72716377
63MP0002733_abnormal_thermal_nociception0.72153070
64MP0001485_abnormal_pinna_reflex0.71013479
65MP0002006_tumorigenesis0.70358628
66MP0002118_abnormal_lipid_homeostasis0.67871608
67MP0001145_abnormal_male_reproductive0.66743623
68MP0001764_abnormal_homeostasis0.64148709
69MP0009384_cardiac_valve_regurgitation0.63709849
70MP0004858_abnormal_nervous_system0.63298911
71MP0004142_abnormal_muscle_tone0.61392539
72MP0003011_delayed_dark_adaptation0.60606541
73MP0000653_abnormal_sex_gland0.60528015
74MP0002653_abnormal_ependyma_morphology0.59935995
75MP0003077_abnormal_cell_cycle0.59829396
76MP0002572_abnormal_emotion/affect_behav0.59525535
77MP0004019_abnormal_vitamin_homeostasis0.58595004
78MP0002751_abnormal_autonomic_nervous0.57890902
79MP0005075_abnormal_melanosome_morpholog0.56343096
80MP0008770_decreased_survivor_rate0.55764841
81MP0002970_abnormal_white_adipose0.54429541
82MP0005332_abnormal_amino_acid0.53950600
83MP0000613_abnormal_salivary_gland0.53181317
84MP0006072_abnormal_retinal_apoptosis0.52759940
85MP0000609_abnormal_liver_physiology0.52507652
86MP0003724_increased_susceptibility_to0.51973568
87MP0002161_abnormal_fertility/fecundity0.51041977
88MP0001486_abnormal_startle_reflex0.49724830
89MP0004264_abnormal_extraembryonic_tissu0.48720187
90MP0002078_abnormal_glucose_homeostasis0.47520477
91MP0002135_abnormal_kidney_morphology0.46751888
92MP0009931_abnormal_skin_appearance0.46611612
93MP0002928_abnormal_bile_duct0.45217709
94MP0010368_abnormal_lymphatic_system0.44545534
95MP0001943_abnormal_respiration0.43200628
96MP0003953_abnormal_hormone_level0.43091899
97MP0003879_abnormal_hair_cell0.42803138
98MP0000427_abnormal_hair_cycle0.42654448
99MP0002229_neurodegeneration0.41984595
100MP0003635_abnormal_synaptic_transmissio0.40097095

Predicted human phenotypes

RankGene SetZ-score
1Generalized hypopigmentation of hair (HP:0011358)6.62510032
2Hypoplasia of the fovea (HP:0007750)6.27479738
3Aplasia/Hypoplasia of the fovea (HP:0008060)6.27479738
4Anterior segment dysgenesis (HP:0007700)5.11019436
5Prominent supraorbital ridges (HP:0000336)4.80832486
6Abnormality of the fovea (HP:0000493)4.80772530
7Curly hair (HP:0002212)4.72594167
8Abnormality of the renal cortex (HP:0011035)4.66448695
9Renal cortical cysts (HP:0000803)4.61551506
10Aplasia/Hypoplasia of the macula (HP:0008059)4.07549867
11Proximal amyotrophy (HP:0007126)3.95511515
12Wormian bones (HP:0002645)3.90131908
13Aplasia/Hypoplasia affecting the retina (HP:0008061)3.75480824
14Generalized hypopigmentation (HP:0007513)3.75420394
15Flat capital femoral epiphysis (HP:0003370)3.75102833
16Ocular albinism (HP:0001107)3.62930274
17Metaphyseal irregularity (HP:0003025)3.54990034
18Thrombocytosis (HP:0001894)3.52492363
19Cone-rod dystrophy (HP:0000548)3.46202936
20Vertebral arch anomaly (HP:0008438)3.45312199
21Abnormal albumin level (HP:0012116)3.44319752
22Hypoalbuminemia (HP:0003073)3.44319752
23Abnormality of methionine metabolism (HP:0010901)3.38781754
24Abnormal hair laboratory examination (HP:0003328)3.37482234
25Absent speech (HP:0001344)3.25216081
26Small epiphyses (HP:0010585)3.24505122
27Cholecystitis (HP:0001082)3.24039881
28Abnormal gallbladder physiology (HP:0012438)3.24039881
29Prominent forehead (HP:0011220)3.21769705
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.17046080
31Abnormality of small intestinal villus morphology (HP:0011472)3.09062091
32Villous atrophy (HP:0011473)3.09062091
33Iris hypopigmentation (HP:0007730)3.07169380
34Increased mean platelet volume (HP:0011877)3.03073480
35Hypoplastic labia majora (HP:0000059)2.98916129
36Delayed epiphyseal ossification (HP:0002663)2.96763571
37Carpal bone hypoplasia (HP:0001498)2.86714793
38Abnormality of the labia majora (HP:0012881)2.82473708
39Tracheomalacia (HP:0002779)2.81069181
40Vacuolated lymphocytes (HP:0001922)2.80930151
41Abnormal platelet volume (HP:0011876)2.80089590
42Hypoplasia of the capital femoral epiphysis (HP:0003090)2.77461593
43Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.76086237
44Nausea (HP:0002018)2.71756524
45Severe visual impairment (HP:0001141)2.68050456
46J-shaped sella turcica (HP:0002680)2.67921065
47Polyuria (HP:0000103)2.65399201
48Irregular epiphyses (HP:0010582)2.65279091
49Hyperaldosteronism (HP:0000859)2.61590299
50Scrotal hypoplasia (HP:0000046)2.58128921
51Aortic regurgitation (HP:0001659)2.56538057
52Chronic hepatic failure (HP:0100626)2.54577902
53Glossoptosis (HP:0000162)2.54170802
54Chorioretinal coloboma (HP:0000567)2.54045365
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.45852250
56Abnormality of iron homeostasis (HP:0011031)2.45386421
57Progressive external ophthalmoplegia (HP:0000590)2.43180320
58Stomach cancer (HP:0012126)2.39904323
59Abnormality of macular pigmentation (HP:0008002)2.38360984
60Woolly hair (HP:0002224)2.33938785
61Broad distal phalanx of finger (HP:0009836)2.33054407
62Abnormality of the proximal phalanges of the hand (HP:0009834)2.28902170
63Abnormality of transition element cation homeostasis (HP:0011030)2.26094392
64Absent epiphyses (HP:0010577)2.22326658
65Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.22326658
66Narrow mouth (HP:0000160)2.21524255
67Esotropia (HP:0000565)2.16887726
68Abnormal urine output (HP:0012590)2.16848725
69Abnormality of chloride homeostasis (HP:0011422)2.15540659
70Flattened epiphyses (HP:0003071)2.15390419
71Brittle hair (HP:0002299)2.14862872
72Low anterior hairline (HP:0000294)2.14411277
73Ependymoma (HP:0002888)2.12781856
74Tubulointerstitial fibrosis (HP:0005576)2.12715200
75Conjugated hyperbilirubinemia (HP:0002908)2.12497580
76Increased corneal curvature (HP:0100692)2.07263034
77Keratoconus (HP:0000563)2.07263034
78Abnormality of the costochondral junction (HP:0000919)2.05142275
79Hypoplasia of the thymus (HP:0000778)2.04455086
80Metabolic alkalosis (HP:0200114)2.03908825
81Overlapping toe (HP:0001845)2.02252209
82Oligodactyly (hands) (HP:0001180)2.02157728
83Labial hypoplasia (HP:0000066)2.02067463
84Hypokalemic alkalosis (HP:0001949)2.01991920
85Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99247114
86Elevated erythrocyte sedimentation rate (HP:0003565)1.98966233
87Polydipsia (HP:0001959)1.98736516
88Abnormal drinking behavior (HP:0030082)1.98736516
89Easy fatigability (HP:0003388)1.97541933
90Agnosia (HP:0010524)1.96247572
91Broad nasal tip (HP:0000455)1.95723308
92Abnormality of the renal medulla (HP:0100957)1.94658274
93Prominent nose (HP:0000448)1.93190700
94Congenital stationary night blindness (HP:0007642)1.91449793
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91028479
96Tetraplegia (HP:0002445)1.88170029
97Rib fusion (HP:0000902)1.87887220
98Gaze-evoked nystagmus (HP:0000640)1.87322308
99Optic nerve hypoplasia (HP:0000609)1.86123691
100Pectus carinatum (HP:0000768)1.85352823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.72387080
2ZAK7.12061489
3CASK6.81552407
4CCNB12.86362882
5MST42.83242987
6CDK122.65308349
7VRK12.13614081
8TSSK62.12508062
9BCKDK1.91679602
10PHKG11.91380981
11PHKG21.91380981
12DAPK21.76286304
13KDR1.67357601
14FRK1.64085399
15FLT31.61237060
16WNK41.59363809
17STK38L1.32072287
18PIM11.17519473
19RPS6KA51.15621886
20PKN11.10880962
21WEE11.10620869
22STK241.08870450
23MAP3K51.08044514
24SIK31.06503434
25PRKCI0.94094475
26BMX0.87319958
27NEK60.86186670
28ICK0.83634481
29DAPK10.83154388
30MELK0.79948224
31TAOK30.79694479
32MKNK20.78552920
33PAK30.77975495
34PRKAA10.75347185
35JAK20.74214250
36NTRK10.72038078
37KSR10.69217647
38PRKCQ0.69053978
39STK390.68147075
40AKT20.66429601
41JAK30.64007156
42EPHA20.61523555
43PNCK0.61168828
44KSR20.59853885
45ROCK10.53957136
46CHUK0.51187944
47CDK60.50019211
48TNK20.49750453
49JAK10.47362153
50MET0.46157254
51STK40.46107239
52MAPK140.46007819
53MAPK100.45508424
54STK100.44425449
55CHEK20.43368548
56PRKAA20.42531017
57PIK3CA0.41466996
58MAPK90.39401301
59MAP3K140.37592951
60CDK70.37287757
61CAMK1G0.32496287
62MATK0.32495489
63TRIM280.31907861
64MAP3K80.31655769
65CDK40.30797413
66CSNK1G30.30140249
67AURKB0.29828044
68DAPK30.29626583
69WNK10.29563717
70IKBKB0.26353393
71GSK3B0.23959791
72CSNK1A1L0.23267619
73CDK20.22862381
74BMPR20.22470828
75PDK10.22375308
76PDPK10.22358666
77MAP4K20.21934811
78DYRK20.21829772
79CSNK1G10.21009034
80PINK10.20561908
81ADRBK20.20548079
82BMPR1B0.19112147
83ZAP700.17707676
84TGFBR20.17615072
85MAP3K10.15426891
86PAK60.14528780
87CDK10.14403107
88MAP2K10.14078024
89MAP3K60.13958409
90LRRK20.13307334
91MAPK110.12865468
92SGK10.12467339
93HIPK20.12200299
94AURKA0.11699587
95TEC0.10549800
96SIK20.10036693
97IKBKE0.09686654
98GRK10.08160995
99ADRBK10.07411698
100MAPK150.06597939

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034105.89174298
2Systemic lupus erythematosus_Homo sapiens_hsa053225.29576973
3Alcoholism_Homo sapiens_hsa050344.34328542
4Selenocompound metabolism_Homo sapiens_hsa004503.12534335
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96362945
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.57416987
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38808184
8Caffeine metabolism_Homo sapiens_hsa002322.32145415
9SNARE interactions in vesicular transport_Homo sapiens_hsa041301.97386667
10Butanoate metabolism_Homo sapiens_hsa006501.87191381
11Viral carcinogenesis_Homo sapiens_hsa052031.87049947
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82449181
13Fructose and mannose metabolism_Homo sapiens_hsa000511.77818342
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74152416
15Transcriptional misregulation in cancer_Homo sapiens_hsa052021.64358035
16Dorso-ventral axis formation_Homo sapiens_hsa043201.61069548
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60852042
18Phototransduction_Homo sapiens_hsa047441.57926254
19Adipocytokine signaling pathway_Homo sapiens_hsa049201.48891671
20Mineral absorption_Homo sapiens_hsa049781.44672102
21RNA polymerase_Homo sapiens_hsa030201.42456938
22Circadian rhythm_Homo sapiens_hsa047101.35405231
23Inositol phosphate metabolism_Homo sapiens_hsa005621.27504691
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26332572
25Olfactory transduction_Homo sapiens_hsa047401.25848720
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24730246
27FoxO signaling pathway_Homo sapiens_hsa040681.03908578
28Amphetamine addiction_Homo sapiens_hsa050311.03488522
29Fanconi anemia pathway_Homo sapiens_hsa034600.97787660
30Taste transduction_Homo sapiens_hsa047420.95563310
31RNA transport_Homo sapiens_hsa030130.93478677
32Arginine and proline metabolism_Homo sapiens_hsa003300.91842367
33Calcium signaling pathway_Homo sapiens_hsa040200.91724511
34Retinol metabolism_Homo sapiens_hsa008300.88535550
35Dopaminergic synapse_Homo sapiens_hsa047280.87796891
36Estrogen signaling pathway_Homo sapiens_hsa049150.81554000
37Circadian entrainment_Homo sapiens_hsa047130.79916074
38African trypanosomiasis_Homo sapiens_hsa051430.78699054
39Lysine degradation_Homo sapiens_hsa003100.77407693
40Gastric acid secretion_Homo sapiens_hsa049710.77348032
41Salivary secretion_Homo sapiens_hsa049700.76975478
42TGF-beta signaling pathway_Homo sapiens_hsa043500.76103367
43Phenylalanine metabolism_Homo sapiens_hsa003600.75881810
44ABC transporters_Homo sapiens_hsa020100.75736109
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73078738
46Insulin secretion_Homo sapiens_hsa049110.70648590
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70149864
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69917492
49Herpes simplex infection_Homo sapiens_hsa051680.65559194
50Cocaine addiction_Homo sapiens_hsa050300.64859960
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63554146
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62370235
53mRNA surveillance pathway_Homo sapiens_hsa030150.61873493
54Arginine biosynthesis_Homo sapiens_hsa002200.60292167
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60109564
56Nicotine addiction_Homo sapiens_hsa050330.57232571
57Serotonergic synapse_Homo sapiens_hsa047260.56869889
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56132258
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55902372
60Glucagon signaling pathway_Homo sapiens_hsa049220.55569266
61Fatty acid biosynthesis_Homo sapiens_hsa000610.54235115
62Linoleic acid metabolism_Homo sapiens_hsa005910.53414802
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.52554059
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52411801
65Bile secretion_Homo sapiens_hsa049760.50637066
66Staphylococcus aureus infection_Homo sapiens_hsa051500.48987916
67cAMP signaling pathway_Homo sapiens_hsa040240.47970663
68Thyroid cancer_Homo sapiens_hsa052160.47879819
69Tyrosine metabolism_Homo sapiens_hsa003500.46965473
70Insulin resistance_Homo sapiens_hsa049310.45381148
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45275799
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45147517
73RNA degradation_Homo sapiens_hsa030180.41911740
74Thyroid hormone synthesis_Homo sapiens_hsa049180.40998153
75Morphine addiction_Homo sapiens_hsa050320.40200272
76AMPK signaling pathway_Homo sapiens_hsa041520.39186631
77Nitrogen metabolism_Homo sapiens_hsa009100.37020274
78Pyrimidine metabolism_Homo sapiens_hsa002400.36099709
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34519641
80TNF signaling pathway_Homo sapiens_hsa046680.32610542
81PPAR signaling pathway_Homo sapiens_hsa033200.32469468
82Regulation of autophagy_Homo sapiens_hsa041400.32342134
83Glycerolipid metabolism_Homo sapiens_hsa005610.30191710
84Antigen processing and presentation_Homo sapiens_hsa046120.29041880
85Type II diabetes mellitus_Homo sapiens_hsa049300.26866615
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25259373
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.25108158
88Ovarian steroidogenesis_Homo sapiens_hsa049130.25072247
89Graft-versus-host disease_Homo sapiens_hsa053320.24262253
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23503748
91Sphingolipid metabolism_Homo sapiens_hsa006000.23074247
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22876932
93Endocytosis_Homo sapiens_hsa041440.22819555
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.21775911
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21293434
96Prolactin signaling pathway_Homo sapiens_hsa049170.20923753
97Cholinergic synapse_Homo sapiens_hsa047250.20312342
98Insulin signaling pathway_Homo sapiens_hsa049100.19477202
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18223329
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18166713

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