LARP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)5.78679333
2mitotic metaphase plate congression (GO:0007080)5.76934728
3nuclear pore organization (GO:0006999)5.51883037
4nuclear pore complex assembly (GO:0051292)5.48903091
5nucleobase biosynthetic process (GO:0046112)5.43820349
6ribosome assembly (GO:0042255)5.28415157
7regulation of spindle organization (GO:0090224)5.11414605
8metaphase plate congression (GO:0051310)4.82502569
9protein localization to kinetochore (GO:0034501)4.79679587
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.75075746
11monoubiquitinated protein deubiquitination (GO:0035520)4.54538951
12mitotic nuclear envelope disassembly (GO:0007077)4.38487357
13positive regulation of chromosome segregation (GO:0051984)4.38021469
14regulation of mitotic spindle organization (GO:0060236)4.36081964
15ribosome biogenesis (GO:0042254)4.35089320
16pore complex assembly (GO:0046931)4.30809521
17DNA unwinding involved in DNA replication (GO:0006268)4.19676410
18membrane disassembly (GO:0030397)4.12057809
19nuclear envelope disassembly (GO:0051081)4.12057809
20protein localization to chromosome, centromeric region (GO:0071459)4.09914999
21DNA replication checkpoint (GO:0000076)4.08268259
22regulation of RNA export from nucleus (GO:0046831)4.06621975
23folic acid metabolic process (GO:0046655)4.00903010
24regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.94687507
25IMP biosynthetic process (GO:0006188)3.93248286
26establishment of chromosome localization (GO:0051303)3.87266191
27spindle checkpoint (GO:0031577)3.70688774
28double-strand break repair via nonhomologous end joining (GO:0006303)3.70293735
29non-recombinational repair (GO:0000726)3.70293735
30attachment of spindle microtubules to kinetochore (GO:0008608)3.70129587
31protein K6-linked ubiquitination (GO:0085020)3.67272540
32establishment of integrated proviral latency (GO:0075713)3.67182733
33CENP-A containing nucleosome assembly (GO:0034080)3.65913420
34histone H2A monoubiquitination (GO:0035518)3.60868469
35DNA strand elongation involved in DNA replication (GO:0006271)3.60254900
36mitotic chromosome condensation (GO:0007076)3.59371837
37regulation of DNA endoreduplication (GO:0032875)3.57208419
38chromatin remodeling at centromere (GO:0031055)3.56600745
39positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.55353371
40positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.55353371
41positive regulation of mitotic sister chromatid separation (GO:1901970)3.55353371
42vitamin transmembrane transport (GO:0035461)3.55339018
43regulation of chromosome segregation (GO:0051983)3.50442151
44formation of translation preinitiation complex (GO:0001731)3.50399936
45regulation of translational termination (GO:0006449)3.49875370
46DNA strand elongation (GO:0022616)3.47280255
47histone-serine phosphorylation (GO:0035404)3.46571480
48mitotic sister chromatid segregation (GO:0000070)3.44463620
49DNA replication-independent nucleosome assembly (GO:0006336)3.44161129
50DNA replication-independent nucleosome organization (GO:0034724)3.44161129
51nuclear envelope organization (GO:0006998)3.42713689
52termination of RNA polymerase I transcription (GO:0006363)3.42229078
53transcription elongation from RNA polymerase I promoter (GO:0006362)3.41498720
54mitotic spindle checkpoint (GO:0071174)3.41387962
55DNA replication initiation (GO:0006270)3.38965058
56mitotic sister chromatid cohesion (GO:0007064)3.38553002
57regulation of centrosome cycle (GO:0046605)3.37622923
58regulation of mitotic metaphase/anaphase transition (GO:0030071)3.35215680
59sister chromatid segregation (GO:0000819)3.33767444
60IMP metabolic process (GO:0046040)3.30504598
61transcription from RNA polymerase I promoter (GO:0006360)3.29205821
62histone exchange (GO:0043486)3.28823215
63transcription initiation from RNA polymerase I promoter (GO:0006361)3.28744936
64kinetochore organization (GO:0051383)3.27938542
65regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.26807269
66protein localization to chromosome (GO:0034502)3.22658588
67spindle assembly checkpoint (GO:0071173)3.21994963
68rRNA modification (GO:0000154)3.21970928
69DNA duplex unwinding (GO:0032508)3.20443504
70negative regulation of chromosome segregation (GO:0051985)3.19730231
71maturation of 5.8S rRNA (GO:0000460)3.19713740
72folic acid-containing compound biosynthetic process (GO:0009396)3.19395759
73telomere maintenance via semi-conservative replication (GO:0032201)3.19310749
74glycine metabolic process (GO:0006544)3.19081263
75folic acid transport (GO:0015884)3.17143171
76negative regulation of mitotic sister chromatid separation (GO:2000816)3.16349137
77negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16349137
78negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16349137
79negative regulation of sister chromatid segregation (GO:0033046)3.16349137
80mitotic spindle assembly checkpoint (GO:0007094)3.16237779
81intestinal epithelial cell development (GO:0060576)3.15289586
82ribonucleoprotein complex biogenesis (GO:0022613)3.15171884
83DNA geometric change (GO:0032392)3.12710281
84regulation of translational fidelity (GO:0006450)3.10352628
85regulation of sister chromatid segregation (GO:0033045)3.08808742
86regulation of mitotic sister chromatid separation (GO:0010965)3.08808742
87regulation of mitotic sister chromatid segregation (GO:0033047)3.08808742
88termination of RNA polymerase III transcription (GO:0006386)3.07305992
89transcription elongation from RNA polymerase III promoter (GO:0006385)3.07305992
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06022561
91regulation of centrosome duplication (GO:0010824)3.05957418
92maturation of SSU-rRNA (GO:0030490)3.05730846
93protein complex localization (GO:0031503)3.05511247
94rRNA processing (GO:0006364)3.05304589
95regulation of translation in response to stress (GO:0043555)3.05250551
96mitotic recombination (GO:0006312)3.05213475
97inner cell mass cell proliferation (GO:0001833)3.04298988
98pre-miRNA processing (GO:0031054)3.03980297
99DNA ligation (GO:0006266)3.02178122
100DNA replication-dependent nucleosome assembly (GO:0006335)3.01609190
101DNA replication-dependent nucleosome organization (GO:0034723)3.01609190
102regulation of nucleobase-containing compound transport (GO:0032239)3.00840571
103cellular protein complex localization (GO:0034629)2.99464346
104microtubule depolymerization (GO:0007019)2.99382093
105rRNA metabolic process (GO:0016072)2.98173290
106kinetochore assembly (GO:0051382)2.97012005
107regulation of helicase activity (GO:0051095)2.95907861
108maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95345438
109negative regulation of DNA-dependent DNA replication (GO:2000104)2.94386073
110negative regulation of DNA repair (GO:0045738)2.93906157
111telomere maintenance via recombination (GO:0000722)2.92805688
112tRNA aminoacylation for protein translation (GO:0006418)2.92540264
113chromosome condensation (GO:0030261)2.89668805
114tRNA aminoacylation (GO:0043039)2.89621846
115amino acid activation (GO:0043038)2.89621846
116sister chromatid cohesion (GO:0007062)2.88454510
117chromosome segregation (GO:0007059)2.86757050
118regulation of sister chromatid cohesion (GO:0007063)2.86561980
119regulation of nuclear cell cycle DNA replication (GO:0033262)2.85862761
120DNA topological change (GO:0006265)2.84052358
1217-methylguanosine mRNA capping (GO:0006370)2.83868911
122histone H2A ubiquitination (GO:0033522)2.82404381
123response to X-ray (GO:0010165)2.82102608
124chromatin assembly or disassembly (GO:0006333)2.82068531
125microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.81638032
126negative regulation of translational initiation (GO:0045947)2.80294148
127regulation of centriole replication (GO:0046599)2.80234412
128DNA conformation change (GO:0071103)2.79456681
129ATP-dependent chromatin remodeling (GO:0043044)2.71585118
130somatic recombination of immunoglobulin gene segments (GO:0016447)2.70696370
131mitotic G2/M transition checkpoint (GO:0044818)2.69696800
132DNA packaging (GO:0006323)2.66157917
133mitotic spindle organization (GO:0007052)2.64541055
134COPII vesicle coating (GO:0048208)2.59907760
135ventricular cardiac muscle cell development (GO:0055015)2.59855836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.61934846
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.62603705
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.70391023
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.69385348
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.25898062
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.14306759
7AR_21909140_ChIP-Seq_LNCAP_Human2.92892465
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.87834490
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.83920235
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75815088
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75485960
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59926681
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.50333420
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.47614774
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.42800303
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42290602
17* GABP_17652178_ChIP-ChIP_JURKAT_Human2.37430354
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.36158304
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31486924
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.31164020
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.25027704
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23059010
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.21380636
24VDR_23849224_ChIP-Seq_CD4+_Human2.17576151
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16340241
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04949320
27MYCN_18555785_ChIP-Seq_MESCs_Mouse2.04636335
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.00034063
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95664993
30XRN2_22483619_ChIP-Seq_HELA_Human1.89040543
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84258766
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81390784
33ELK1_19687146_ChIP-ChIP_HELA_Human1.81314057
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76387761
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75165292
36KDM5A_27292631_Chip-Seq_BREAST_Human1.74017174
37FOXP3_21729870_ChIP-Seq_TREG_Human1.66538311
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.65656845
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64413129
40* GABP_19822575_ChIP-Seq_HepG2_Human1.62426605
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60900138
42DCP1A_22483619_ChIP-Seq_HELA_Human1.55682747
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54199194
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.52436756
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43845084
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38050023
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32691590
48KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31645080
49* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31546073
50* TTF2_22483619_ChIP-Seq_HELA_Human1.31006314
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28043341
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27980565
53FUS_26573619_Chip-Seq_HEK293_Human1.27272546
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26397001
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25494859
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.23717896
57* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21972201
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21037306
59* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20589633
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20316614
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18441536
62ZNF263_19887448_ChIP-Seq_K562_Human1.17433780
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17263098
64CIITA_25753668_ChIP-Seq_RAJI_Human1.17064907
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16721232
66MYC_22102868_ChIP-Seq_BL_Human1.16058388
67EWS_26573619_Chip-Seq_HEK293_Human1.16041504
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15850176
69* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13802074
70GATA1_22025678_ChIP-Seq_K562_Human1.13337072
71SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13098621
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12995129
73* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11801726
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.11353485
75SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06728927
76* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06727115
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04266066
78TFEB_21752829_ChIP-Seq_HELA_Human1.03451104
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03378125
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02526224
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.02096004
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01038823
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.00875599
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00583392
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00290491
86CHD1_26751641_Chip-Seq_LNCaP_Human0.98535554
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98412845
88* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98262420
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97692558
90ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95911676
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95224812
92SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94896001
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93808494
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93381406
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.92683384
96FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92220208
97* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92028119
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91600644
99YY1_21170310_ChIP-Seq_MESCs_Mouse0.91022218
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90642623
101MYC_18940864_ChIP-ChIP_HL60_Human0.89382531
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88911770
103EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88353621
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87063835
105* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86676480
106* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86484639
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85813886
108* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85454887
109HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.82981134
110SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81751712
111SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81751712
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81091868
113FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80762537
114SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.79972589
115GATA4_21415370_ChIP-Seq_HL-1_Mouse0.79801082
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79459784
117TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79452702
118KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79310272
119NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77695073
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77680287
121TAF15_26573619_Chip-Seq_HEK293_Human0.77540220
122* SRF_21415370_ChIP-Seq_HL-1_Mouse0.77343651
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77000001
124SOX17_20123909_ChIP-Seq_XEN_Mouse0.76895514
125BRD4_25478319_ChIP-Seq_HGPS_Human0.76884214
126CLOCK_20551151_ChIP-Seq_293T_Human0.75653442
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.74335002
128KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.74154688
129KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.74154688
130KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.74154688

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.43733542
2MP0003111_abnormal_nucleus_morphology4.21803775
3MP0008057_abnormal_DNA_replication4.05707966
4MP0010094_abnormal_chromosome_stability4.03517293
5MP0004957_abnormal_blastocyst_morpholog3.91363692
6MP0003077_abnormal_cell_cycle3.57804859
7MP0003718_maternal_effect2.75003711
8MP0010307_abnormal_tumor_latency2.67145898
9MP0008007_abnormal_cellular_replicative2.62543089
10MP0008058_abnormal_DNA_repair2.52820564
11MP0001730_embryonic_growth_arrest2.51085039
12MP0003123_paternal_imprinting2.43313837
13MP0002396_abnormal_hematopoietic_system2.35116465
14MP0010352_gastrointestinal_tract_polyps2.24548418
15MP0000350_abnormal_cell_proliferation2.19577829
16MP0001672_abnormal_embryogenesis/_devel2.08898562
17MP0005380_embryogenesis_phenotype2.08898562
18MP0003786_premature_aging2.08432309
19MP0008932_abnormal_embryonic_tissue2.02496140
20MP0003984_embryonic_growth_retardation1.91890024
21MP0002088_abnormal_embryonic_growth/wei1.88066334
22MP0008877_abnormal_DNA_methylation1.85628435
23MP0001697_abnormal_embryo_size1.74127120
24MP0004233_abnormal_muscle_weight1.66829144
25MP0002086_abnormal_extraembryonic_tissu1.64737425
26MP0003567_abnormal_fetal_cardiomyocyte1.60387319
27MP0002877_abnormal_melanocyte_morpholog1.59481382
28MP0005076_abnormal_cell_differentiation1.57161819
29MP0004264_abnormal_extraembryonic_tissu1.52910297
30MP0002080_prenatal_lethality1.52671163
31MP0004272_abnormal_basement_membrane1.48266323
32MP0002084_abnormal_developmental_patter1.44128363
33MP0008260_abnormal_autophagy1.43365854
34MP0002085_abnormal_embryonic_tissue1.42017624
35MP0004197_abnormal_fetal_growth/weight/1.41689043
36MP0002009_preneoplasia1.36008389
37MP0002697_abnormal_eye_size1.32491098
38MP0009672_abnormal_birth_weight1.29199139
39MP0001661_extended_life_span1.28510714
40MP0004808_abnormal_hematopoietic_stem1.27802516
41MP0005408_hypopigmentation1.27093018
42MP0003705_abnormal_hypodermis_morpholog1.25902237
43MP0005397_hematopoietic_system_phenotyp1.10694972
44MP0001545_abnormal_hematopoietic_system1.10694972
45MP0000313_abnormal_cell_death1.09970837
46MP0009703_decreased_birth_body1.09570195
47MP0000490_abnormal_crypts_of1.09108528
48MP0003221_abnormal_cardiomyocyte_apopto1.06021815
49MP0003937_abnormal_limbs/digits/tail_de1.05716176
50MP0002019_abnormal_tumor_incidence1.05592559
51MP0000627_abnormal_mammary_gland1.05328495
52MP0009053_abnormal_anal_canal1.04932603
53MP0005395_other_phenotype1.04415543
54MP0002210_abnormal_sex_determination1.03855144
55MP0003121_genomic_imprinting1.03300216
56MP0003890_abnormal_embryonic-extraembry1.01312294
57MP0003868_abnormal_feces_composition1.00546106
58MP0000358_abnormal_cell_content/1.00287405
59MP0001293_anophthalmia0.99456512
60MP0002796_impaired_skin_barrier0.97729853
61MP0001145_abnormal_male_reproductive0.95112187
62MP0002269_muscular_atrophy0.93747842
63MP0003941_abnormal_skin_development0.92882803
64MP0010234_abnormal_vibrissa_follicle0.91596600
65MP0009333_abnormal_splenocyte_physiolog0.91297694
66MP0005220_abnormal_exocrine_pancreas0.90831127
67MP0005621_abnormal_cell_physiology0.90399198
68MP0004215_abnormal_myocardial_fiber0.89411726
69MP0000653_abnormal_sex_gland0.88534153
70MP0005187_abnormal_penis_morphology0.87413620
71MP0003315_abnormal_perineum_morphology0.86222765
72MP0002233_abnormal_nose_morphology0.85592811
73MP0010030_abnormal_orbit_morphology0.84804875
74MP0000647_abnormal_sebaceous_gland0.84767496
75MP0003943_abnormal_hepatobiliary_system0.84184082
76MP0000579_abnormal_nail_morphology0.83284311
77MP0002092_abnormal_eye_morphology0.82515562
78MP0006035_abnormal_mitochondrial_morpho0.81851917
79MP0001929_abnormal_gametogenesis0.81647743
80MP0002166_altered_tumor_susceptibility0.81504028
81MP0001119_abnormal_female_reproductive0.81117561
82MP0005384_cellular_phenotype0.80771235
83MP0000762_abnormal_tongue_morphology0.80356537
84MP0005501_abnormal_skin_physiology0.79719557
85MP0003755_abnormal_palate_morphology0.78938975
86MP0005451_abnormal_body_composition0.78560806
87MP0009697_abnormal_copulation0.78245928
88MP0003806_abnormal_nucleotide_metabolis0.78199125
89MP0000750_abnormal_muscle_regeneration0.77892289
90MP0003935_abnormal_craniofacial_develop0.77830916
91MP0001666_abnormal_nutrient_absorption0.76792735
92MP0000428_abnormal_craniofacial_morphol0.76665196
93MP0000383_abnormal_hair_follicle0.76354164
94MP0005365_abnormal_bile_salt0.75810030
95MP0002938_white_spotting0.75603213
96MP0005248_abnormal_Harderian_gland0.75108760
97MP0001881_abnormal_mammary_gland0.74921675
98MP0009840_abnormal_foam_cell0.74694564
99MP0004084_abnormal_cardiac_muscle0.74690956
100MP0005389_reproductive_system_phenotype0.74665668
101MP0010678_abnormal_skin_adnexa0.73964908
102MP0003699_abnormal_female_reproductive0.73224834
103MP0000537_abnormal_urethra_morphology0.72327994
104MP0005330_cardiomyopathy0.71260341
105MP0003936_abnormal_reproductive_system0.71190068
106MP0002006_tumorigenesis0.70989330
107MP0002060_abnormal_skin_morphology0.70272988
108MP0002254_reproductive_system_inflammat0.67118541
109MP0001542_abnormal_bone_strength0.65506864
110MP0000749_muscle_degeneration0.64886522
111MP0003385_abnormal_body_wall0.64261975
112MP0001915_intracranial_hemorrhage0.64198334
113MP0004185_abnormal_adipocyte_glucose0.63712268
114MP0001286_abnormal_eye_development0.63445247
115MP0000598_abnormal_liver_morphology0.63013975
116MP0010630_abnormal_cardiac_muscle0.62769652
117MP0002160_abnormal_reproductive_system0.61915804
118MP0000372_irregular_coat_pigmentation0.61444976
119MP0001299_abnormal_eye_distance/0.60966934
120MP0002234_abnormal_pharynx_morphology0.60505510
121MP0000377_abnormal_hair_follicle0.60045942
122MP0002111_abnormal_tail_morphology0.59925211
123MP0003119_abnormal_digestive_system0.59618823
124MP0000432_abnormal_head_morphology0.59005544
125MP0005367_renal/urinary_system_phenotyp0.58905334
126MP0000516_abnormal_urinary_system0.58905334
127MP0003566_abnormal_cell_adhesion0.57883408
128MP0001216_abnormal_epidermal_layer0.57804500
129MP0003950_abnormal_plasma_membrane0.56505851
130MP0002139_abnormal_hepatobiliary_system0.56497705
131MP0000733_abnormal_muscle_development0.56381356
132MP0001919_abnormal_reproductive_system0.56308779
133MP0000609_abnormal_liver_physiology0.55022328

Predicted human phenotypes

RankGene SetZ-score
1Impulsivity (HP:0100710)5.32372417
2Birth length less than 3rd percentile (HP:0003561)5.30151186
3Hyperglycinemia (HP:0002154)4.40909774
4Breast hypoplasia (HP:0003187)4.29418559
5Chromsome breakage (HP:0040012)3.64601901
6Abnormality of the labia minora (HP:0012880)3.45914415
7Hyperglycinuria (HP:0003108)3.42885049
8Entropion (HP:0000621)3.40571399
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.34273367
10Patellar aplasia (HP:0006443)3.25492036
11Carpal bone hypoplasia (HP:0001498)3.20905428
12Aplasia/Hypoplasia of the patella (HP:0006498)3.16829496
13Abnormality of chromosome stability (HP:0003220)3.15862681
14Ureteral duplication (HP:0000073)3.13709464
15Nephroblastoma (Wilms tumor) (HP:0002667)3.13154845
16Rough bone trabeculation (HP:0100670)3.10513574
17Embryonal renal neoplasm (HP:0011794)3.02604168
18Degeneration of anterior horn cells (HP:0002398)2.91500572
19Abnormality of the anterior horn cell (HP:0006802)2.91500572
20Facial hemangioma (HP:0000329)2.89401475
21Abnormality of glycine metabolism (HP:0010895)2.82766360
22Abnormality of serine family amino acid metabolism (HP:0010894)2.82766360
23Increased nuchal translucency (HP:0010880)2.76998810
24Osteolytic defects of the hand bones (HP:0009699)2.66910686
25Osteolytic defects of the phalanges of the hand (HP:0009771)2.66910686
26Absent radius (HP:0003974)2.64521654
27Abnormality of the preputium (HP:0100587)2.62731892
28Meckel diverticulum (HP:0002245)2.61553768
29Stillbirth (HP:0003826)2.60533315
30Abnormality of methionine metabolism (HP:0010901)2.58584704
31Cerebral hypomyelination (HP:0006808)2.55492270
32Abnormality of the umbilical cord (HP:0010881)2.54740761
33Capillary hemangiomas (HP:0005306)2.52844427
34Cortical dysplasia (HP:0002539)2.48214816
35Abnormal biliary tract morphology (HP:0012440)2.47452614
36Hyperglycemia (HP:0003074)2.45510223
37Colon cancer (HP:0003003)2.45320998
38Abnormal lung lobation (HP:0002101)2.45312824
39Sparse lateral eyebrow (HP:0005338)2.42735007
40Aplasia involving forearm bones (HP:0009822)2.42105520
41Absent forearm bone (HP:0003953)2.42105520
42Abnormal spermatogenesis (HP:0008669)2.41512454
43Hypobetalipoproteinemia (HP:0003563)2.41317048
44Prominent nose (HP:0000448)2.38659175
45Abnormal trabecular bone morphology (HP:0100671)2.38537466
46Abnormality of glycolysis (HP:0004366)2.36560087
47Secondary amenorrhea (HP:0000869)2.36250054
48Pelvic girdle muscle weakness (HP:0003749)2.34500581
49Abnormality of the ileum (HP:0001549)2.33929945
50Oligodactyly (hands) (HP:0001180)2.31553127
51Abnormality of the duodenum (HP:0002246)2.30681825
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.30676383
53Abnormality of serum amino acid levels (HP:0003112)2.29396325
54Increased serum pyruvate (HP:0003542)2.28128813
55Deep philtrum (HP:0002002)2.27830561
56Ependymoma (HP:0002888)2.27010409
57Oral leukoplakia (HP:0002745)2.24363467
58Biliary tract neoplasm (HP:0100574)2.23830368
59Progressive external ophthalmoplegia (HP:0000590)2.22410043
60Myelodysplasia (HP:0002863)2.21327221
61Termporal pattern (HP:0011008)2.20504006
62Insidious onset (HP:0003587)2.20504006
63Multiple enchondromatosis (HP:0005701)2.19618024
64Selective tooth agenesis (HP:0001592)2.19513031
65Microglossia (HP:0000171)2.18656504
66Abnormality of the distal phalanges of the toes (HP:0010182)2.18634524
67Thyroid carcinoma (HP:0002890)2.14111343
68Acute myeloid leukemia (HP:0004808)2.10611586
69Small intestinal stenosis (HP:0012848)2.09673404
70Duodenal stenosis (HP:0100867)2.09673404
71Ankyloglossia (HP:0010296)2.09466143
72Neoplasm of the pancreas (HP:0002894)2.09040936
73Spinal muscular atrophy (HP:0007269)2.07320009
74Choanal atresia (HP:0000453)2.06196125
75Ankle contracture (HP:0006466)2.05985810
76Ectopic kidney (HP:0000086)2.05804502
77Areflexia of lower limbs (HP:0002522)2.04085991
78Premature rupture of membranes (HP:0001788)2.04065392
79Oligodactyly (HP:0012165)2.02692610
80Bone marrow hypocellularity (HP:0005528)2.02221031
81Squamous cell carcinoma (HP:0002860)1.99540244
82Overlapping toe (HP:0001845)1.99167614
83Spastic diplegia (HP:0001264)1.99121562
84Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.98629585
85Abnormality of the astrocytes (HP:0100707)1.98537068
86Astrocytoma (HP:0009592)1.98537068
87Deviation of the thumb (HP:0009603)1.97904742
88Cutaneous melanoma (HP:0012056)1.97646535
89Aplasia/hypoplasia of the humerus (HP:0006507)1.97547680
90Single umbilical artery (HP:0001195)1.97263330
91Abnormality of the fetal cardiovascular system (HP:0010948)1.97263330
92Abnormal umbilical cord blood vessels (HP:0011403)1.97263330
93Gout (HP:0001997)1.96603684
94Volvulus (HP:0002580)1.96207907
95Neoplasm of the colon (HP:0100273)1.95060693
96Shoulder girdle muscle weakness (HP:0003547)1.92971828
97Neoplasm of the small intestine (HP:0100833)1.92912471
98Abnormality of the carotid arteries (HP:0005344)1.91941302
99Abnormal auditory evoked potentials (HP:0006958)1.91918802
100Cafe-au-lait spot (HP:0000957)1.91229674
101Prostate neoplasm (HP:0100787)1.91101948
102Glioma (HP:0009733)1.90867751
103Horseshoe kidney (HP:0000085)1.90247002
104Medulloblastoma (HP:0002885)1.90191636
105Glossoptosis (HP:0000162)1.89346505
106Shawl scrotum (HP:0000049)1.89168744
107Right ventricular cardiomyopathy (HP:0011663)1.89073073
108Malignant gastrointestinal tract tumors (HP:0006749)1.88828852
109Gastrointestinal carcinoma (HP:0002672)1.88828852
110Proximal placement of thumb (HP:0009623)1.88081813
111Rhabdomyosarcoma (HP:0002859)1.87800145
112Sloping forehead (HP:0000340)1.87495729
113Abnormality of the intrinsic pathway (HP:0010989)1.87344356
114Bifid tongue (HP:0010297)1.87310931
115Premature ovarian failure (HP:0008209)1.86595130
116Glucose intolerance (HP:0000833)1.86465261
117Abnormality of the musculature of the pelvis (HP:0001469)1.84976673
118Abnormality of the hip-girdle musculature (HP:0001445)1.84976673
119Progressive muscle weakness (HP:0003323)1.84779415
120Breast carcinoma (HP:0003002)1.84693869
121Reduced subcutaneous adipose tissue (HP:0003758)1.84633172
122Azoospermia (HP:0000027)1.84452140
123Uterine neoplasm (HP:0010784)1.84361903
124Embryonal neoplasm (HP:0002898)1.83295874
125Breast aplasia (HP:0100783)1.82001395
126Papillary thyroid carcinoma (HP:0002895)1.81761951
127Microretrognathia (HP:0000308)1.81504016
128Septate vagina (HP:0001153)1.80701381
129Submucous cleft hard palate (HP:0000176)1.80608465
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79377621
131Abnormality of alanine metabolism (HP:0010916)1.79377621
132Hyperalaninemia (HP:0003348)1.79377621
133Exercise-induced muscle cramps (HP:0003710)1.79242395
134Atresia of the external auditory canal (HP:0000413)1.79071343
135Leiomyosarcoma (HP:0100243)1.77856370
136Uterine leiomyosarcoma (HP:0002891)1.77856370
137Missing ribs (HP:0000921)1.77028558
138Abnormality of oral frenula (HP:0000190)1.76971621
139Megaloblastic anemia (HP:0001889)1.76642351
140Tetraplegia (HP:0002445)1.76563692
141Short nail (HP:0001799)1.76176391
142Absent thumb (HP:0009777)1.75932636
143Hypolipoproteinemia (HP:0010981)1.75676735
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.75195667
145Ovarian neoplasm (HP:0100615)1.73842353
146Abnormality of chromosome segregation (HP:0002916)1.73604588
147Abnormality of the proximal phalanges of the hand (HP:0009834)1.73310726
148Short humerus (HP:0005792)1.72701353
149Curly hair (HP:0002212)1.72608673
150Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72213015
151Intrahepatic cholestasis (HP:0001406)1.70920686
152Microvesicular hepatic steatosis (HP:0001414)1.70609044
153Gonadotropin excess (HP:0000837)1.70188981
154Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69601044
155Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67814391
156Pancreatic islet-cell hyperplasia (HP:0004510)1.67738004
157Anal stenosis (HP:0002025)1.67467494
158Cystic hygroma (HP:0000476)1.66166056
159Abnormal foot bone ossification (HP:0010675)1.65456130
160Facial cleft (HP:0002006)1.63745742
161Transitional cell carcinoma of the bladder (HP:0006740)1.63717946
162Abnormalities of placenta or umbilical cord (HP:0001194)1.62314181
163Neoplasm of the adrenal gland (HP:0100631)1.61920503

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.16620532
2BUB13.77080907
3BRSK23.27520842
4PBK3.20715010
5TSSK63.13688289
6LATS12.82005918
7SRPK12.79228724
8CDC72.71711937
9NEK22.68532049
10AKT32.68204982
11PLK32.52510920
12EIF2AK12.48036514
13PLK42.46324071
14MKNK22.27234233
15TTK2.21022684
16TAF12.19384853
17STK32.13007231
18MKNK12.04647010
19PLK11.96616273
20STK38L1.89873735
21EIF2AK31.88340396
22ZAK1.87860071
23EPHA21.82980999
24NEK11.79106668
25ACVR1B1.76536789
26CDK121.70981224
27AURKB1.63155742
28MST1R1.62072350
29BRSK11.60347410
30TRIM281.51704139
31CHEK21.49668193
32ERBB31.38321534
33NME21.37776262
34RPS6KA41.37681051
35NUAK11.33885412
36FRK1.33194805
37CHEK11.28888595
38DYRK31.27207951
39ATR1.25271938
40VRK11.25271586
41CDK71.22695832
42MET1.20307723
43CDK41.19955315
44LATS21.18938540
45ALK1.15557718
46MAP3K81.09051929
47STK101.06985882
48IRAK31.05726818
49TNIK1.04837111
50ATM0.99305372
51PIM10.98463370
52CDK60.97641001
53PNCK0.97292099
54PDK30.96856921
55PDK40.96856921
56RPS6KB20.96670106
57NEK90.96167474
58BCR0.93830161
59BMPR1B0.92646548
60STK40.92483637
61STK390.89170759
62PAK40.88304898
63CDK20.85735372
64PDK20.85530683
65MARK30.85392815
66PASK0.84312638
67MELK0.82726090
68SMG10.81911991
69AURKA0.80254828
70STK240.75370554
71CCNB10.72803120
72EIF2AK20.70044951
73MAP3K120.69535921
74MTOR0.68827310
75MAP3K100.68823914
76VRK20.68405642
77SCYL20.67975091
78CDK10.66534336
79EEF2K0.65625310
80CAMK1G0.64732111
81KSR10.64709263
82CSNK2A20.59499891
83CLK10.57451986
84CDK80.57013270
85CSNK1E0.56750220
86BRD40.54851912
87TLK10.54445631
88PRKCI0.54171563
89TGFBR10.53833479
90MAP3K90.53291515
91PLK20.52427937
92CSNK2A10.49429124
93CDK90.49322239
94MST40.48694889
95PRKAA10.47900363
96PAK20.47684344
97MAP3K30.46564790
98CDK30.46032421
99RPS6KA50.45107744
100STK160.44839917
101OBSCN0.42475066
102DMPK0.42220694
103PDGFRA0.41420671
104CHUK0.40909402
105PIM20.39816134
106YES10.39053397
107FER0.38784868
108RPS6KB10.35725129
109ERBB40.35125187
110NEK60.34954681
111BRAF0.33022681
112CSNK1A1L0.32890974
113PRKDC0.32515372
114CSNK1G10.32105636
115CSNK1D0.30397524
116MAPK140.29795552
117MAP3K50.29063831
118FLT30.26789155
119CSNK1G30.26484578
120FGFR10.26413354
121MAP2K30.24340355
122AKT20.24235726
123CAMK1D0.23742218
124RAF10.23506590
125PAK10.23486249
126MAPK100.21882887
127TRPM70.20077096

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.80768267
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.65404287
3RNA polymerase_Homo sapiens_hsa030203.91765854
4RNA transport_Homo sapiens_hsa030133.56100728
5Cell cycle_Homo sapiens_hsa041102.94542220
6DNA replication_Homo sapiens_hsa030302.83315709
7Mismatch repair_Homo sapiens_hsa034302.57950553
8Spliceosome_Homo sapiens_hsa030402.56849589
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.43701996
10One carbon pool by folate_Homo sapiens_hsa006702.26974248
11Basal transcription factors_Homo sapiens_hsa030222.20765895
12Pyrimidine metabolism_Homo sapiens_hsa002402.16533346
13Nucleotide excision repair_Homo sapiens_hsa034202.14353163
14Homologous recombination_Homo sapiens_hsa034402.14147825
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97784008
16p53 signaling pathway_Homo sapiens_hsa041151.85822038
17Fanconi anemia pathway_Homo sapiens_hsa034601.85315768
18Proteasome_Homo sapiens_hsa030501.82695717
19Propanoate metabolism_Homo sapiens_hsa006401.81203621
20Base excision repair_Homo sapiens_hsa034101.81002817
21RNA degradation_Homo sapiens_hsa030181.73638080
22Pyruvate metabolism_Homo sapiens_hsa006201.73066110
23mRNA surveillance pathway_Homo sapiens_hsa030151.72705276
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69703875
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68964548
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.52218108
27Non-homologous end-joining_Homo sapiens_hsa034501.51131000
28Selenocompound metabolism_Homo sapiens_hsa004501.41091669
29Folate biosynthesis_Homo sapiens_hsa007901.38687601
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33461921
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31148543
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30116378
33Purine metabolism_Homo sapiens_hsa002301.29184536
34Steroid biosynthesis_Homo sapiens_hsa001001.25751110
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.25522077
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.23600355
37Regulation of autophagy_Homo sapiens_hsa041401.22243169
38Epstein-Barr virus infection_Homo sapiens_hsa051691.21442156
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19113871
40Vitamin digestion and absorption_Homo sapiens_hsa049771.14484153
41Pentose phosphate pathway_Homo sapiens_hsa000301.10521834
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10124649
43Systemic lupus erythematosus_Homo sapiens_hsa053221.09861747
44Viral carcinogenesis_Homo sapiens_hsa052031.04920260
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03781238
46Antigen processing and presentation_Homo sapiens_hsa046121.01783519
47Oocyte meiosis_Homo sapiens_hsa041140.99349797
48Biosynthesis of amino acids_Homo sapiens_hsa012300.97492679
49Fatty acid metabolism_Homo sapiens_hsa012120.94171387
50Fatty acid degradation_Homo sapiens_hsa000710.88854582
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88468668
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87926566
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86488866
54MicroRNAs in cancer_Homo sapiens_hsa052060.86167760
55Ribosome_Homo sapiens_hsa030100.84466141
56Small cell lung cancer_Homo sapiens_hsa052220.83584556
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82977512
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82429050
59Fatty acid elongation_Homo sapiens_hsa000620.80331042
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77836428
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76921836
62Herpes simplex infection_Homo sapiens_hsa051680.76490466
63Sulfur metabolism_Homo sapiens_hsa009200.74925648
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73398240
65Caffeine metabolism_Homo sapiens_hsa002320.72746275
66Thyroid cancer_Homo sapiens_hsa052160.69251041
67mTOR signaling pathway_Homo sapiens_hsa041500.66809428
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64595055
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.63778192
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.62057918
71HTLV-I infection_Homo sapiens_hsa051660.58016811
72Prostate cancer_Homo sapiens_hsa052150.55609749
73TGF-beta signaling pathway_Homo sapiens_hsa043500.54667343
74Butanoate metabolism_Homo sapiens_hsa006500.53979120
75FoxO signaling pathway_Homo sapiens_hsa040680.52183737
76Retinol metabolism_Homo sapiens_hsa008300.49827920
77beta-Alanine metabolism_Homo sapiens_hsa004100.48727412
78Proteoglycans in cancer_Homo sapiens_hsa052050.47565387
79Carbon metabolism_Homo sapiens_hsa012000.44844484
80Protein export_Homo sapiens_hsa030600.44759693
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.44313568
82Adherens junction_Homo sapiens_hsa045200.42335128
83Colorectal cancer_Homo sapiens_hsa052100.39448992
84Renin-angiotensin system_Homo sapiens_hsa046140.39057032
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38632210
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.37419168
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37405118
88Hippo signaling pathway_Homo sapiens_hsa043900.36808073
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36696109
90Starch and sucrose metabolism_Homo sapiens_hsa005000.36621757
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.35784117
92Tyrosine metabolism_Homo sapiens_hsa003500.34583739
93Lysine degradation_Homo sapiens_hsa003100.34376266
94Legionellosis_Homo sapiens_hsa051340.34115122
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33901461
96Wnt signaling pathway_Homo sapiens_hsa043100.32925934
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32799519
98Basal cell carcinoma_Homo sapiens_hsa052170.31321138
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31176244
100Phenylalanine metabolism_Homo sapiens_hsa003600.30095510
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29534562
102Fructose and mannose metabolism_Homo sapiens_hsa000510.28667134
103Hepatitis B_Homo sapiens_hsa051610.28638699
104Circadian rhythm_Homo sapiens_hsa047100.28557246
105Sphingolipid metabolism_Homo sapiens_hsa006000.28204670
106Pancreatic cancer_Homo sapiens_hsa052120.27668994
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.27382222
108Apoptosis_Homo sapiens_hsa042100.26623374
109ECM-receptor interaction_Homo sapiens_hsa045120.26310496
110Melanoma_Homo sapiens_hsa052180.26252259
111Arginine and proline metabolism_Homo sapiens_hsa003300.26020632
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25452652
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25392982
114Fatty acid biosynthesis_Homo sapiens_hsa000610.25041330
115HIF-1 signaling pathway_Homo sapiens_hsa040660.24204555
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23843676
117Sulfur relay system_Homo sapiens_hsa041220.21616721
118Inositol phosphate metabolism_Homo sapiens_hsa005620.20941885
119Influenza A_Homo sapiens_hsa051640.20909100
120Chronic myeloid leukemia_Homo sapiens_hsa052200.20801559
121Metabolic pathways_Homo sapiens_hsa011000.20770554
122Glutathione metabolism_Homo sapiens_hsa004800.19553122
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.18090540
124Bladder cancer_Homo sapiens_hsa052190.16162312
125Measles_Homo sapiens_hsa051620.16048733
126Endometrial cancer_Homo sapiens_hsa052130.15482847
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15268029
128Renal cell carcinoma_Homo sapiens_hsa052110.15266412
129N-Glycan biosynthesis_Homo sapiens_hsa005100.13582235
130Arginine biosynthesis_Homo sapiens_hsa002200.12732744
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.12060928
132Tight junction_Homo sapiens_hsa045300.11874228
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11675392
134Pathways in cancer_Homo sapiens_hsa052000.11403070
135AMPK signaling pathway_Homo sapiens_hsa041520.10876320
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.08737579

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