

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | purine nucleobase biosynthetic process (GO:0009113) | 5.78679333 |
| 2 | mitotic metaphase plate congression (GO:0007080) | 5.76934728 |
| 3 | nuclear pore organization (GO:0006999) | 5.51883037 |
| 4 | nuclear pore complex assembly (GO:0051292) | 5.48903091 |
| 5 | nucleobase biosynthetic process (GO:0046112) | 5.43820349 |
| 6 | ribosome assembly (GO:0042255) | 5.28415157 |
| 7 | regulation of spindle organization (GO:0090224) | 5.11414605 |
| 8 | metaphase plate congression (GO:0051310) | 4.82502569 |
| 9 | protein localization to kinetochore (GO:0034501) | 4.79679587 |
| 10 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 4.75075746 |
| 11 | monoubiquitinated protein deubiquitination (GO:0035520) | 4.54538951 |
| 12 | mitotic nuclear envelope disassembly (GO:0007077) | 4.38487357 |
| 13 | positive regulation of chromosome segregation (GO:0051984) | 4.38021469 |
| 14 | regulation of mitotic spindle organization (GO:0060236) | 4.36081964 |
| 15 | ribosome biogenesis (GO:0042254) | 4.35089320 |
| 16 | pore complex assembly (GO:0046931) | 4.30809521 |
| 17 | DNA unwinding involved in DNA replication (GO:0006268) | 4.19676410 |
| 18 | membrane disassembly (GO:0030397) | 4.12057809 |
| 19 | nuclear envelope disassembly (GO:0051081) | 4.12057809 |
| 20 | protein localization to chromosome, centromeric region (GO:0071459) | 4.09914999 |
| 21 | DNA replication checkpoint (GO:0000076) | 4.08268259 |
| 22 | regulation of RNA export from nucleus (GO:0046831) | 4.06621975 |
| 23 | folic acid metabolic process (GO:0046655) | 4.00903010 |
| 24 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.94687507 |
| 25 | IMP biosynthetic process (GO:0006188) | 3.93248286 |
| 26 | establishment of chromosome localization (GO:0051303) | 3.87266191 |
| 27 | spindle checkpoint (GO:0031577) | 3.70688774 |
| 28 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.70293735 |
| 29 | non-recombinational repair (GO:0000726) | 3.70293735 |
| 30 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.70129587 |
| 31 | protein K6-linked ubiquitination (GO:0085020) | 3.67272540 |
| 32 | establishment of integrated proviral latency (GO:0075713) | 3.67182733 |
| 33 | CENP-A containing nucleosome assembly (GO:0034080) | 3.65913420 |
| 34 | histone H2A monoubiquitination (GO:0035518) | 3.60868469 |
| 35 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.60254900 |
| 36 | mitotic chromosome condensation (GO:0007076) | 3.59371837 |
| 37 | regulation of DNA endoreduplication (GO:0032875) | 3.57208419 |
| 38 | chromatin remodeling at centromere (GO:0031055) | 3.56600745 |
| 39 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.55353371 |
| 40 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.55353371 |
| 41 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.55353371 |
| 42 | vitamin transmembrane transport (GO:0035461) | 3.55339018 |
| 43 | regulation of chromosome segregation (GO:0051983) | 3.50442151 |
| 44 | formation of translation preinitiation complex (GO:0001731) | 3.50399936 |
| 45 | regulation of translational termination (GO:0006449) | 3.49875370 |
| 46 | DNA strand elongation (GO:0022616) | 3.47280255 |
| 47 | histone-serine phosphorylation (GO:0035404) | 3.46571480 |
| 48 | mitotic sister chromatid segregation (GO:0000070) | 3.44463620 |
| 49 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.44161129 |
| 50 | DNA replication-independent nucleosome organization (GO:0034724) | 3.44161129 |
| 51 | nuclear envelope organization (GO:0006998) | 3.42713689 |
| 52 | termination of RNA polymerase I transcription (GO:0006363) | 3.42229078 |
| 53 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.41498720 |
| 54 | mitotic spindle checkpoint (GO:0071174) | 3.41387962 |
| 55 | DNA replication initiation (GO:0006270) | 3.38965058 |
| 56 | mitotic sister chromatid cohesion (GO:0007064) | 3.38553002 |
| 57 | regulation of centrosome cycle (GO:0046605) | 3.37622923 |
| 58 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.35215680 |
| 59 | sister chromatid segregation (GO:0000819) | 3.33767444 |
| 60 | IMP metabolic process (GO:0046040) | 3.30504598 |
| 61 | transcription from RNA polymerase I promoter (GO:0006360) | 3.29205821 |
| 62 | histone exchange (GO:0043486) | 3.28823215 |
| 63 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.28744936 |
| 64 | kinetochore organization (GO:0051383) | 3.27938542 |
| 65 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.26807269 |
| 66 | protein localization to chromosome (GO:0034502) | 3.22658588 |
| 67 | spindle assembly checkpoint (GO:0071173) | 3.21994963 |
| 68 | rRNA modification (GO:0000154) | 3.21970928 |
| 69 | DNA duplex unwinding (GO:0032508) | 3.20443504 |
| 70 | negative regulation of chromosome segregation (GO:0051985) | 3.19730231 |
| 71 | maturation of 5.8S rRNA (GO:0000460) | 3.19713740 |
| 72 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.19395759 |
| 73 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.19310749 |
| 74 | glycine metabolic process (GO:0006544) | 3.19081263 |
| 75 | folic acid transport (GO:0015884) | 3.17143171 |
| 76 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.16349137 |
| 77 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.16349137 |
| 78 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.16349137 |
| 79 | negative regulation of sister chromatid segregation (GO:0033046) | 3.16349137 |
| 80 | mitotic spindle assembly checkpoint (GO:0007094) | 3.16237779 |
| 81 | intestinal epithelial cell development (GO:0060576) | 3.15289586 |
| 82 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.15171884 |
| 83 | DNA geometric change (GO:0032392) | 3.12710281 |
| 84 | regulation of translational fidelity (GO:0006450) | 3.10352628 |
| 85 | regulation of sister chromatid segregation (GO:0033045) | 3.08808742 |
| 86 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.08808742 |
| 87 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.08808742 |
| 88 | termination of RNA polymerase III transcription (GO:0006386) | 3.07305992 |
| 89 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.07305992 |
| 90 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.06022561 |
| 91 | regulation of centrosome duplication (GO:0010824) | 3.05957418 |
| 92 | maturation of SSU-rRNA (GO:0030490) | 3.05730846 |
| 93 | protein complex localization (GO:0031503) | 3.05511247 |
| 94 | rRNA processing (GO:0006364) | 3.05304589 |
| 95 | regulation of translation in response to stress (GO:0043555) | 3.05250551 |
| 96 | mitotic recombination (GO:0006312) | 3.05213475 |
| 97 | inner cell mass cell proliferation (GO:0001833) | 3.04298988 |
| 98 | pre-miRNA processing (GO:0031054) | 3.03980297 |
| 99 | DNA ligation (GO:0006266) | 3.02178122 |
| 100 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.01609190 |
| 101 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.01609190 |
| 102 | regulation of nucleobase-containing compound transport (GO:0032239) | 3.00840571 |
| 103 | cellular protein complex localization (GO:0034629) | 2.99464346 |
| 104 | microtubule depolymerization (GO:0007019) | 2.99382093 |
| 105 | rRNA metabolic process (GO:0016072) | 2.98173290 |
| 106 | kinetochore assembly (GO:0051382) | 2.97012005 |
| 107 | regulation of helicase activity (GO:0051095) | 2.95907861 |
| 108 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.95345438 |
| 109 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.94386073 |
| 110 | negative regulation of DNA repair (GO:0045738) | 2.93906157 |
| 111 | telomere maintenance via recombination (GO:0000722) | 2.92805688 |
| 112 | tRNA aminoacylation for protein translation (GO:0006418) | 2.92540264 |
| 113 | chromosome condensation (GO:0030261) | 2.89668805 |
| 114 | tRNA aminoacylation (GO:0043039) | 2.89621846 |
| 115 | amino acid activation (GO:0043038) | 2.89621846 |
| 116 | sister chromatid cohesion (GO:0007062) | 2.88454510 |
| 117 | chromosome segregation (GO:0007059) | 2.86757050 |
| 118 | regulation of sister chromatid cohesion (GO:0007063) | 2.86561980 |
| 119 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.85862761 |
| 120 | DNA topological change (GO:0006265) | 2.84052358 |
| 121 | 7-methylguanosine mRNA capping (GO:0006370) | 2.83868911 |
| 122 | histone H2A ubiquitination (GO:0033522) | 2.82404381 |
| 123 | response to X-ray (GO:0010165) | 2.82102608 |
| 124 | chromatin assembly or disassembly (GO:0006333) | 2.82068531 |
| 125 | microtubule cytoskeleton organization involved in mitosis (GO:1902850) | 2.81638032 |
| 126 | negative regulation of translational initiation (GO:0045947) | 2.80294148 |
| 127 | regulation of centriole replication (GO:0046599) | 2.80234412 |
| 128 | DNA conformation change (GO:0071103) | 2.79456681 |
| 129 | ATP-dependent chromatin remodeling (GO:0043044) | 2.71585118 |
| 130 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 2.70696370 |
| 131 | mitotic G2/M transition checkpoint (GO:0044818) | 2.69696800 |
| 132 | DNA packaging (GO:0006323) | 2.66157917 |
| 133 | mitotic spindle organization (GO:0007052) | 2.64541055 |
| 134 | COPII vesicle coating (GO:0048208) | 2.59907760 |
| 135 | ventricular cardiac muscle cell development (GO:0055015) | 2.59855836 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.61934846 |
| 2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.62603705 |
| 3 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.70391023 |
| 4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.69385348 |
| 5 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.25898062 |
| 6 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.14306759 |
| 7 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.92892465 |
| 8 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.87834490 |
| 9 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.83920235 |
| 10 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.75815088 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.75485960 |
| 12 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.59926681 |
| 13 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.50333420 |
| 14 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.47614774 |
| 15 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.42800303 |
| 16 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.42290602 |
| 17 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.37430354 |
| 18 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.36158304 |
| 19 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.31486924 |
| 20 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.31164020 |
| 21 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.25027704 |
| 22 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.23059010 |
| 23 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.21380636 |
| 24 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.17576151 |
| 25 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.16340241 |
| 26 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.04949320 |
| 27 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 2.04636335 |
| 28 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.00034063 |
| 29 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.95664993 |
| 30 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.89040543 |
| 31 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.84258766 |
| 32 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.81390784 |
| 33 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.81314057 |
| 34 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.76387761 |
| 35 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.75165292 |
| 36 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.74017174 |
| 37 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.66538311 |
| 38 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.65656845 |
| 39 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.64413129 |
| 40 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.62426605 |
| 41 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.60900138 |
| 42 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.55682747 |
| 43 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.54199194 |
| 44 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.52436756 |
| 45 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.43845084 |
| 46 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.38050023 |
| 47 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.32691590 |
| 48 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.31645080 |
| 49 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.31546073 |
| 50 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.31006314 |
| 51 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.28043341 |
| 52 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.27980565 |
| 53 | FUS_26573619_Chip-Seq_HEK293_Human | 1.27272546 |
| 54 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.26397001 |
| 55 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.25494859 |
| 56 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.23717896 |
| 57 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.21972201 |
| 58 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.21037306 |
| 59 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.20589633 |
| 60 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.20316614 |
| 61 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.18441536 |
| 62 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.17433780 |
| 63 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.17263098 |
| 64 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.17064907 |
| 65 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.16721232 |
| 66 | MYC_22102868_ChIP-Seq_BL_Human | 1.16058388 |
| 67 | EWS_26573619_Chip-Seq_HEK293_Human | 1.16041504 |
| 68 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.15850176 |
| 69 | * FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.13802074 |
| 70 | GATA1_22025678_ChIP-Seq_K562_Human | 1.13337072 |
| 71 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.13098621 |
| 72 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.12995129 |
| 73 | * HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.11801726 |
| 74 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.11353485 |
| 75 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.06728927 |
| 76 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.06727115 |
| 77 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.04266066 |
| 78 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.03451104 |
| 79 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.03378125 |
| 80 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.02526224 |
| 81 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.02096004 |
| 82 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.01038823 |
| 83 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.00875599 |
| 84 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.00583392 |
| 85 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.00290491 |
| 86 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.98535554 |
| 87 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.98412845 |
| 88 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.98262420 |
| 89 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.97692558 |
| 90 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.95911676 |
| 91 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.95224812 |
| 92 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.94896001 |
| 93 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.93808494 |
| 94 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.93381406 |
| 95 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.92683384 |
| 96 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.92220208 |
| 97 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.92028119 |
| 98 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.91600644 |
| 99 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.91022218 |
| 100 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.90642623 |
| 101 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.89382531 |
| 102 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.88911770 |
| 103 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.88353621 |
| 104 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.87063835 |
| 105 | * FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.86676480 |
| 106 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.86484639 |
| 107 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.85813886 |
| 108 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.85454887 |
| 109 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.82981134 |
| 110 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.81751712 |
| 111 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.81751712 |
| 112 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.81091868 |
| 113 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.80762537 |
| 114 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.79972589 |
| 115 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 0.79801082 |
| 116 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.79459784 |
| 117 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.79452702 |
| 118 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.79310272 |
| 119 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.77695073 |
| 120 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.77680287 |
| 121 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.77540220 |
| 122 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.77343651 |
| 123 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.77000001 |
| 124 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.76895514 |
| 125 | BRD4_25478319_ChIP-Seq_HGPS_Human | 0.76884214 |
| 126 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.75653442 |
| 127 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.74335002 |
| 128 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.74154688 |
| 129 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.74154688 |
| 130 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.74154688 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.43733542 |
| 2 | MP0003111_abnormal_nucleus_morphology | 4.21803775 |
| 3 | MP0008057_abnormal_DNA_replication | 4.05707966 |
| 4 | MP0010094_abnormal_chromosome_stability | 4.03517293 |
| 5 | MP0004957_abnormal_blastocyst_morpholog | 3.91363692 |
| 6 | MP0003077_abnormal_cell_cycle | 3.57804859 |
| 7 | MP0003718_maternal_effect | 2.75003711 |
| 8 | MP0010307_abnormal_tumor_latency | 2.67145898 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.62543089 |
| 10 | MP0008058_abnormal_DNA_repair | 2.52820564 |
| 11 | MP0001730_embryonic_growth_arrest | 2.51085039 |
| 12 | MP0003123_paternal_imprinting | 2.43313837 |
| 13 | MP0002396_abnormal_hematopoietic_system | 2.35116465 |
| 14 | MP0010352_gastrointestinal_tract_polyps | 2.24548418 |
| 15 | MP0000350_abnormal_cell_proliferation | 2.19577829 |
| 16 | MP0001672_abnormal_embryogenesis/_devel | 2.08898562 |
| 17 | MP0005380_embryogenesis_phenotype | 2.08898562 |
| 18 | MP0003786_premature_aging | 2.08432309 |
| 19 | MP0008932_abnormal_embryonic_tissue | 2.02496140 |
| 20 | MP0003984_embryonic_growth_retardation | 1.91890024 |
| 21 | MP0002088_abnormal_embryonic_growth/wei | 1.88066334 |
| 22 | MP0008877_abnormal_DNA_methylation | 1.85628435 |
| 23 | MP0001697_abnormal_embryo_size | 1.74127120 |
| 24 | MP0004233_abnormal_muscle_weight | 1.66829144 |
| 25 | MP0002086_abnormal_extraembryonic_tissu | 1.64737425 |
| 26 | MP0003567_abnormal_fetal_cardiomyocyte | 1.60387319 |
| 27 | MP0002877_abnormal_melanocyte_morpholog | 1.59481382 |
| 28 | MP0005076_abnormal_cell_differentiation | 1.57161819 |
| 29 | MP0004264_abnormal_extraembryonic_tissu | 1.52910297 |
| 30 | MP0002080_prenatal_lethality | 1.52671163 |
| 31 | MP0004272_abnormal_basement_membrane | 1.48266323 |
| 32 | MP0002084_abnormal_developmental_patter | 1.44128363 |
| 33 | MP0008260_abnormal_autophagy | 1.43365854 |
| 34 | MP0002085_abnormal_embryonic_tissue | 1.42017624 |
| 35 | MP0004197_abnormal_fetal_growth/weight/ | 1.41689043 |
| 36 | MP0002009_preneoplasia | 1.36008389 |
| 37 | MP0002697_abnormal_eye_size | 1.32491098 |
| 38 | MP0009672_abnormal_birth_weight | 1.29199139 |
| 39 | MP0001661_extended_life_span | 1.28510714 |
| 40 | MP0004808_abnormal_hematopoietic_stem | 1.27802516 |
| 41 | MP0005408_hypopigmentation | 1.27093018 |
| 42 | MP0003705_abnormal_hypodermis_morpholog | 1.25902237 |
| 43 | MP0005397_hematopoietic_system_phenotyp | 1.10694972 |
| 44 | MP0001545_abnormal_hematopoietic_system | 1.10694972 |
| 45 | MP0000313_abnormal_cell_death | 1.09970837 |
| 46 | MP0009703_decreased_birth_body | 1.09570195 |
| 47 | MP0000490_abnormal_crypts_of | 1.09108528 |
| 48 | MP0003221_abnormal_cardiomyocyte_apopto | 1.06021815 |
| 49 | MP0003937_abnormal_limbs/digits/tail_de | 1.05716176 |
| 50 | MP0002019_abnormal_tumor_incidence | 1.05592559 |
| 51 | MP0000627_abnormal_mammary_gland | 1.05328495 |
| 52 | MP0009053_abnormal_anal_canal | 1.04932603 |
| 53 | MP0005395_other_phenotype | 1.04415543 |
| 54 | MP0002210_abnormal_sex_determination | 1.03855144 |
| 55 | MP0003121_genomic_imprinting | 1.03300216 |
| 56 | MP0003890_abnormal_embryonic-extraembry | 1.01312294 |
| 57 | MP0003868_abnormal_feces_composition | 1.00546106 |
| 58 | MP0000358_abnormal_cell_content/ | 1.00287405 |
| 59 | MP0001293_anophthalmia | 0.99456512 |
| 60 | MP0002796_impaired_skin_barrier | 0.97729853 |
| 61 | MP0001145_abnormal_male_reproductive | 0.95112187 |
| 62 | MP0002269_muscular_atrophy | 0.93747842 |
| 63 | MP0003941_abnormal_skin_development | 0.92882803 |
| 64 | MP0010234_abnormal_vibrissa_follicle | 0.91596600 |
| 65 | MP0009333_abnormal_splenocyte_physiolog | 0.91297694 |
| 66 | MP0005220_abnormal_exocrine_pancreas | 0.90831127 |
| 67 | MP0005621_abnormal_cell_physiology | 0.90399198 |
| 68 | MP0004215_abnormal_myocardial_fiber | 0.89411726 |
| 69 | MP0000653_abnormal_sex_gland | 0.88534153 |
| 70 | MP0005187_abnormal_penis_morphology | 0.87413620 |
| 71 | MP0003315_abnormal_perineum_morphology | 0.86222765 |
| 72 | MP0002233_abnormal_nose_morphology | 0.85592811 |
| 73 | MP0010030_abnormal_orbit_morphology | 0.84804875 |
| 74 | MP0000647_abnormal_sebaceous_gland | 0.84767496 |
| 75 | MP0003943_abnormal_hepatobiliary_system | 0.84184082 |
| 76 | MP0000579_abnormal_nail_morphology | 0.83284311 |
| 77 | MP0002092_abnormal_eye_morphology | 0.82515562 |
| 78 | MP0006035_abnormal_mitochondrial_morpho | 0.81851917 |
| 79 | MP0001929_abnormal_gametogenesis | 0.81647743 |
| 80 | MP0002166_altered_tumor_susceptibility | 0.81504028 |
| 81 | MP0001119_abnormal_female_reproductive | 0.81117561 |
| 82 | MP0005384_cellular_phenotype | 0.80771235 |
| 83 | MP0000762_abnormal_tongue_morphology | 0.80356537 |
| 84 | MP0005501_abnormal_skin_physiology | 0.79719557 |
| 85 | MP0003755_abnormal_palate_morphology | 0.78938975 |
| 86 | MP0005451_abnormal_body_composition | 0.78560806 |
| 87 | MP0009697_abnormal_copulation | 0.78245928 |
| 88 | MP0003806_abnormal_nucleotide_metabolis | 0.78199125 |
| 89 | MP0000750_abnormal_muscle_regeneration | 0.77892289 |
| 90 | MP0003935_abnormal_craniofacial_develop | 0.77830916 |
| 91 | MP0001666_abnormal_nutrient_absorption | 0.76792735 |
| 92 | MP0000428_abnormal_craniofacial_morphol | 0.76665196 |
| 93 | MP0000383_abnormal_hair_follicle | 0.76354164 |
| 94 | MP0005365_abnormal_bile_salt | 0.75810030 |
| 95 | MP0002938_white_spotting | 0.75603213 |
| 96 | MP0005248_abnormal_Harderian_gland | 0.75108760 |
| 97 | MP0001881_abnormal_mammary_gland | 0.74921675 |
| 98 | MP0009840_abnormal_foam_cell | 0.74694564 |
| 99 | MP0004084_abnormal_cardiac_muscle | 0.74690956 |
| 100 | MP0005389_reproductive_system_phenotype | 0.74665668 |
| 101 | MP0010678_abnormal_skin_adnexa | 0.73964908 |
| 102 | MP0003699_abnormal_female_reproductive | 0.73224834 |
| 103 | MP0000537_abnormal_urethra_morphology | 0.72327994 |
| 104 | MP0005330_cardiomyopathy | 0.71260341 |
| 105 | MP0003936_abnormal_reproductive_system | 0.71190068 |
| 106 | MP0002006_tumorigenesis | 0.70989330 |
| 107 | MP0002060_abnormal_skin_morphology | 0.70272988 |
| 108 | MP0002254_reproductive_system_inflammat | 0.67118541 |
| 109 | MP0001542_abnormal_bone_strength | 0.65506864 |
| 110 | MP0000749_muscle_degeneration | 0.64886522 |
| 111 | MP0003385_abnormal_body_wall | 0.64261975 |
| 112 | MP0001915_intracranial_hemorrhage | 0.64198334 |
| 113 | MP0004185_abnormal_adipocyte_glucose | 0.63712268 |
| 114 | MP0001286_abnormal_eye_development | 0.63445247 |
| 115 | MP0000598_abnormal_liver_morphology | 0.63013975 |
| 116 | MP0010630_abnormal_cardiac_muscle | 0.62769652 |
| 117 | MP0002160_abnormal_reproductive_system | 0.61915804 |
| 118 | MP0000372_irregular_coat_pigmentation | 0.61444976 |
| 119 | MP0001299_abnormal_eye_distance/ | 0.60966934 |
| 120 | MP0002234_abnormal_pharynx_morphology | 0.60505510 |
| 121 | MP0000377_abnormal_hair_follicle | 0.60045942 |
| 122 | MP0002111_abnormal_tail_morphology | 0.59925211 |
| 123 | MP0003119_abnormal_digestive_system | 0.59618823 |
| 124 | MP0000432_abnormal_head_morphology | 0.59005544 |
| 125 | MP0005367_renal/urinary_system_phenotyp | 0.58905334 |
| 126 | MP0000516_abnormal_urinary_system | 0.58905334 |
| 127 | MP0003566_abnormal_cell_adhesion | 0.57883408 |
| 128 | MP0001216_abnormal_epidermal_layer | 0.57804500 |
| 129 | MP0003950_abnormal_plasma_membrane | 0.56505851 |
| 130 | MP0002139_abnormal_hepatobiliary_system | 0.56497705 |
| 131 | MP0000733_abnormal_muscle_development | 0.56381356 |
| 132 | MP0001919_abnormal_reproductive_system | 0.56308779 |
| 133 | MP0000609_abnormal_liver_physiology | 0.55022328 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Impulsivity (HP:0100710) | 5.32372417 |
| 2 | Birth length less than 3rd percentile (HP:0003561) | 5.30151186 |
| 3 | Hyperglycinemia (HP:0002154) | 4.40909774 |
| 4 | Breast hypoplasia (HP:0003187) | 4.29418559 |
| 5 | Chromsome breakage (HP:0040012) | 3.64601901 |
| 6 | Abnormality of the labia minora (HP:0012880) | 3.45914415 |
| 7 | Hyperglycinuria (HP:0003108) | 3.42885049 |
| 8 | Entropion (HP:0000621) | 3.40571399 |
| 9 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.34273367 |
| 10 | Patellar aplasia (HP:0006443) | 3.25492036 |
| 11 | Carpal bone hypoplasia (HP:0001498) | 3.20905428 |
| 12 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.16829496 |
| 13 | Abnormality of chromosome stability (HP:0003220) | 3.15862681 |
| 14 | Ureteral duplication (HP:0000073) | 3.13709464 |
| 15 | Nephroblastoma (Wilms tumor) (HP:0002667) | 3.13154845 |
| 16 | Rough bone trabeculation (HP:0100670) | 3.10513574 |
| 17 | Embryonal renal neoplasm (HP:0011794) | 3.02604168 |
| 18 | Degeneration of anterior horn cells (HP:0002398) | 2.91500572 |
| 19 | Abnormality of the anterior horn cell (HP:0006802) | 2.91500572 |
| 20 | Facial hemangioma (HP:0000329) | 2.89401475 |
| 21 | Abnormality of glycine metabolism (HP:0010895) | 2.82766360 |
| 22 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.82766360 |
| 23 | Increased nuchal translucency (HP:0010880) | 2.76998810 |
| 24 | Osteolytic defects of the hand bones (HP:0009699) | 2.66910686 |
| 25 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.66910686 |
| 26 | Absent radius (HP:0003974) | 2.64521654 |
| 27 | Abnormality of the preputium (HP:0100587) | 2.62731892 |
| 28 | Meckel diverticulum (HP:0002245) | 2.61553768 |
| 29 | Stillbirth (HP:0003826) | 2.60533315 |
| 30 | Abnormality of methionine metabolism (HP:0010901) | 2.58584704 |
| 31 | Cerebral hypomyelination (HP:0006808) | 2.55492270 |
| 32 | Abnormality of the umbilical cord (HP:0010881) | 2.54740761 |
| 33 | Capillary hemangiomas (HP:0005306) | 2.52844427 |
| 34 | Cortical dysplasia (HP:0002539) | 2.48214816 |
| 35 | Abnormal biliary tract morphology (HP:0012440) | 2.47452614 |
| 36 | Hyperglycemia (HP:0003074) | 2.45510223 |
| 37 | Colon cancer (HP:0003003) | 2.45320998 |
| 38 | Abnormal lung lobation (HP:0002101) | 2.45312824 |
| 39 | Sparse lateral eyebrow (HP:0005338) | 2.42735007 |
| 40 | Aplasia involving forearm bones (HP:0009822) | 2.42105520 |
| 41 | Absent forearm bone (HP:0003953) | 2.42105520 |
| 42 | Abnormal spermatogenesis (HP:0008669) | 2.41512454 |
| 43 | Hypobetalipoproteinemia (HP:0003563) | 2.41317048 |
| 44 | Prominent nose (HP:0000448) | 2.38659175 |
| 45 | Abnormal trabecular bone morphology (HP:0100671) | 2.38537466 |
| 46 | Abnormality of glycolysis (HP:0004366) | 2.36560087 |
| 47 | Secondary amenorrhea (HP:0000869) | 2.36250054 |
| 48 | Pelvic girdle muscle weakness (HP:0003749) | 2.34500581 |
| 49 | Abnormality of the ileum (HP:0001549) | 2.33929945 |
| 50 | Oligodactyly (hands) (HP:0001180) | 2.31553127 |
| 51 | Abnormality of the duodenum (HP:0002246) | 2.30681825 |
| 52 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.30676383 |
| 53 | Abnormality of serum amino acid levels (HP:0003112) | 2.29396325 |
| 54 | Increased serum pyruvate (HP:0003542) | 2.28128813 |
| 55 | Deep philtrum (HP:0002002) | 2.27830561 |
| 56 | Ependymoma (HP:0002888) | 2.27010409 |
| 57 | Oral leukoplakia (HP:0002745) | 2.24363467 |
| 58 | Biliary tract neoplasm (HP:0100574) | 2.23830368 |
| 59 | Progressive external ophthalmoplegia (HP:0000590) | 2.22410043 |
| 60 | Myelodysplasia (HP:0002863) | 2.21327221 |
| 61 | Termporal pattern (HP:0011008) | 2.20504006 |
| 62 | Insidious onset (HP:0003587) | 2.20504006 |
| 63 | Multiple enchondromatosis (HP:0005701) | 2.19618024 |
| 64 | Selective tooth agenesis (HP:0001592) | 2.19513031 |
| 65 | Microglossia (HP:0000171) | 2.18656504 |
| 66 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.18634524 |
| 67 | Thyroid carcinoma (HP:0002890) | 2.14111343 |
| 68 | Acute myeloid leukemia (HP:0004808) | 2.10611586 |
| 69 | Small intestinal stenosis (HP:0012848) | 2.09673404 |
| 70 | Duodenal stenosis (HP:0100867) | 2.09673404 |
| 71 | Ankyloglossia (HP:0010296) | 2.09466143 |
| 72 | Neoplasm of the pancreas (HP:0002894) | 2.09040936 |
| 73 | Spinal muscular atrophy (HP:0007269) | 2.07320009 |
| 74 | Choanal atresia (HP:0000453) | 2.06196125 |
| 75 | Ankle contracture (HP:0006466) | 2.05985810 |
| 76 | Ectopic kidney (HP:0000086) | 2.05804502 |
| 77 | Areflexia of lower limbs (HP:0002522) | 2.04085991 |
| 78 | Premature rupture of membranes (HP:0001788) | 2.04065392 |
| 79 | Oligodactyly (HP:0012165) | 2.02692610 |
| 80 | Bone marrow hypocellularity (HP:0005528) | 2.02221031 |
| 81 | Squamous cell carcinoma (HP:0002860) | 1.99540244 |
| 82 | Overlapping toe (HP:0001845) | 1.99167614 |
| 83 | Spastic diplegia (HP:0001264) | 1.99121562 |
| 84 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.98629585 |
| 85 | Abnormality of the astrocytes (HP:0100707) | 1.98537068 |
| 86 | Astrocytoma (HP:0009592) | 1.98537068 |
| 87 | Deviation of the thumb (HP:0009603) | 1.97904742 |
| 88 | Cutaneous melanoma (HP:0012056) | 1.97646535 |
| 89 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.97547680 |
| 90 | Single umbilical artery (HP:0001195) | 1.97263330 |
| 91 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.97263330 |
| 92 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.97263330 |
| 93 | Gout (HP:0001997) | 1.96603684 |
| 94 | Volvulus (HP:0002580) | 1.96207907 |
| 95 | Neoplasm of the colon (HP:0100273) | 1.95060693 |
| 96 | Shoulder girdle muscle weakness (HP:0003547) | 1.92971828 |
| 97 | Neoplasm of the small intestine (HP:0100833) | 1.92912471 |
| 98 | Abnormality of the carotid arteries (HP:0005344) | 1.91941302 |
| 99 | Abnormal auditory evoked potentials (HP:0006958) | 1.91918802 |
| 100 | Cafe-au-lait spot (HP:0000957) | 1.91229674 |
| 101 | Prostate neoplasm (HP:0100787) | 1.91101948 |
| 102 | Glioma (HP:0009733) | 1.90867751 |
| 103 | Horseshoe kidney (HP:0000085) | 1.90247002 |
| 104 | Medulloblastoma (HP:0002885) | 1.90191636 |
| 105 | Glossoptosis (HP:0000162) | 1.89346505 |
| 106 | Shawl scrotum (HP:0000049) | 1.89168744 |
| 107 | Right ventricular cardiomyopathy (HP:0011663) | 1.89073073 |
| 108 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.88828852 |
| 109 | Gastrointestinal carcinoma (HP:0002672) | 1.88828852 |
| 110 | Proximal placement of thumb (HP:0009623) | 1.88081813 |
| 111 | Rhabdomyosarcoma (HP:0002859) | 1.87800145 |
| 112 | Sloping forehead (HP:0000340) | 1.87495729 |
| 113 | Abnormality of the intrinsic pathway (HP:0010989) | 1.87344356 |
| 114 | Bifid tongue (HP:0010297) | 1.87310931 |
| 115 | Premature ovarian failure (HP:0008209) | 1.86595130 |
| 116 | Glucose intolerance (HP:0000833) | 1.86465261 |
| 117 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.84976673 |
| 118 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.84976673 |
| 119 | Progressive muscle weakness (HP:0003323) | 1.84779415 |
| 120 | Breast carcinoma (HP:0003002) | 1.84693869 |
| 121 | Reduced subcutaneous adipose tissue (HP:0003758) | 1.84633172 |
| 122 | Azoospermia (HP:0000027) | 1.84452140 |
| 123 | Uterine neoplasm (HP:0010784) | 1.84361903 |
| 124 | Embryonal neoplasm (HP:0002898) | 1.83295874 |
| 125 | Breast aplasia (HP:0100783) | 1.82001395 |
| 126 | Papillary thyroid carcinoma (HP:0002895) | 1.81761951 |
| 127 | Microretrognathia (HP:0000308) | 1.81504016 |
| 128 | Septate vagina (HP:0001153) | 1.80701381 |
| 129 | Submucous cleft hard palate (HP:0000176) | 1.80608465 |
| 130 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.79377621 |
| 131 | Abnormality of alanine metabolism (HP:0010916) | 1.79377621 |
| 132 | Hyperalaninemia (HP:0003348) | 1.79377621 |
| 133 | Exercise-induced muscle cramps (HP:0003710) | 1.79242395 |
| 134 | Atresia of the external auditory canal (HP:0000413) | 1.79071343 |
| 135 | Leiomyosarcoma (HP:0100243) | 1.77856370 |
| 136 | Uterine leiomyosarcoma (HP:0002891) | 1.77856370 |
| 137 | Missing ribs (HP:0000921) | 1.77028558 |
| 138 | Abnormality of oral frenula (HP:0000190) | 1.76971621 |
| 139 | Megaloblastic anemia (HP:0001889) | 1.76642351 |
| 140 | Tetraplegia (HP:0002445) | 1.76563692 |
| 141 | Short nail (HP:0001799) | 1.76176391 |
| 142 | Absent thumb (HP:0009777) | 1.75932636 |
| 143 | Hypolipoproteinemia (HP:0010981) | 1.75676735 |
| 144 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.75195667 |
| 145 | Ovarian neoplasm (HP:0100615) | 1.73842353 |
| 146 | Abnormality of chromosome segregation (HP:0002916) | 1.73604588 |
| 147 | Abnormality of the proximal phalanges of the hand (HP:0009834) | 1.73310726 |
| 148 | Short humerus (HP:0005792) | 1.72701353 |
| 149 | Curly hair (HP:0002212) | 1.72608673 |
| 150 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.72213015 |
| 151 | Intrahepatic cholestasis (HP:0001406) | 1.70920686 |
| 152 | Microvesicular hepatic steatosis (HP:0001414) | 1.70609044 |
| 153 | Gonadotropin excess (HP:0000837) | 1.70188981 |
| 154 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.69601044 |
| 155 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.67814391 |
| 156 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.67738004 |
| 157 | Anal stenosis (HP:0002025) | 1.67467494 |
| 158 | Cystic hygroma (HP:0000476) | 1.66166056 |
| 159 | Abnormal foot bone ossification (HP:0010675) | 1.65456130 |
| 160 | Facial cleft (HP:0002006) | 1.63745742 |
| 161 | Transitional cell carcinoma of the bladder (HP:0006740) | 1.63717946 |
| 162 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.62314181 |
| 163 | Neoplasm of the adrenal gland (HP:0100631) | 1.61920503 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | WEE1 | 4.16620532 |
| 2 | BUB1 | 3.77080907 |
| 3 | BRSK2 | 3.27520842 |
| 4 | PBK | 3.20715010 |
| 5 | TSSK6 | 3.13688289 |
| 6 | LATS1 | 2.82005918 |
| 7 | SRPK1 | 2.79228724 |
| 8 | CDC7 | 2.71711937 |
| 9 | NEK2 | 2.68532049 |
| 10 | AKT3 | 2.68204982 |
| 11 | PLK3 | 2.52510920 |
| 12 | EIF2AK1 | 2.48036514 |
| 13 | PLK4 | 2.46324071 |
| 14 | MKNK2 | 2.27234233 |
| 15 | TTK | 2.21022684 |
| 16 | TAF1 | 2.19384853 |
| 17 | STK3 | 2.13007231 |
| 18 | MKNK1 | 2.04647010 |
| 19 | PLK1 | 1.96616273 |
| 20 | STK38L | 1.89873735 |
| 21 | EIF2AK3 | 1.88340396 |
| 22 | ZAK | 1.87860071 |
| 23 | EPHA2 | 1.82980999 |
| 24 | NEK1 | 1.79106668 |
| 25 | ACVR1B | 1.76536789 |
| 26 | CDK12 | 1.70981224 |
| 27 | AURKB | 1.63155742 |
| 28 | MST1R | 1.62072350 |
| 29 | BRSK1 | 1.60347410 |
| 30 | TRIM28 | 1.51704139 |
| 31 | CHEK2 | 1.49668193 |
| 32 | ERBB3 | 1.38321534 |
| 33 | NME2 | 1.37776262 |
| 34 | RPS6KA4 | 1.37681051 |
| 35 | NUAK1 | 1.33885412 |
| 36 | FRK | 1.33194805 |
| 37 | CHEK1 | 1.28888595 |
| 38 | DYRK3 | 1.27207951 |
| 39 | ATR | 1.25271938 |
| 40 | VRK1 | 1.25271586 |
| 41 | CDK7 | 1.22695832 |
| 42 | MET | 1.20307723 |
| 43 | CDK4 | 1.19955315 |
| 44 | LATS2 | 1.18938540 |
| 45 | ALK | 1.15557718 |
| 46 | MAP3K8 | 1.09051929 |
| 47 | STK10 | 1.06985882 |
| 48 | IRAK3 | 1.05726818 |
| 49 | TNIK | 1.04837111 |
| 50 | ATM | 0.99305372 |
| 51 | PIM1 | 0.98463370 |
| 52 | CDK6 | 0.97641001 |
| 53 | PNCK | 0.97292099 |
| 54 | PDK3 | 0.96856921 |
| 55 | PDK4 | 0.96856921 |
| 56 | RPS6KB2 | 0.96670106 |
| 57 | NEK9 | 0.96167474 |
| 58 | BCR | 0.93830161 |
| 59 | BMPR1B | 0.92646548 |
| 60 | STK4 | 0.92483637 |
| 61 | STK39 | 0.89170759 |
| 62 | PAK4 | 0.88304898 |
| 63 | CDK2 | 0.85735372 |
| 64 | PDK2 | 0.85530683 |
| 65 | MARK3 | 0.85392815 |
| 66 | PASK | 0.84312638 |
| 67 | MELK | 0.82726090 |
| 68 | SMG1 | 0.81911991 |
| 69 | AURKA | 0.80254828 |
| 70 | STK24 | 0.75370554 |
| 71 | CCNB1 | 0.72803120 |
| 72 | EIF2AK2 | 0.70044951 |
| 73 | MAP3K12 | 0.69535921 |
| 74 | MTOR | 0.68827310 |
| 75 | MAP3K10 | 0.68823914 |
| 76 | VRK2 | 0.68405642 |
| 77 | SCYL2 | 0.67975091 |
| 78 | CDK1 | 0.66534336 |
| 79 | EEF2K | 0.65625310 |
| 80 | CAMK1G | 0.64732111 |
| 81 | KSR1 | 0.64709263 |
| 82 | CSNK2A2 | 0.59499891 |
| 83 | CLK1 | 0.57451986 |
| 84 | CDK8 | 0.57013270 |
| 85 | CSNK1E | 0.56750220 |
| 86 | BRD4 | 0.54851912 |
| 87 | TLK1 | 0.54445631 |
| 88 | PRKCI | 0.54171563 |
| 89 | TGFBR1 | 0.53833479 |
| 90 | MAP3K9 | 0.53291515 |
| 91 | PLK2 | 0.52427937 |
| 92 | CSNK2A1 | 0.49429124 |
| 93 | CDK9 | 0.49322239 |
| 94 | MST4 | 0.48694889 |
| 95 | PRKAA1 | 0.47900363 |
| 96 | PAK2 | 0.47684344 |
| 97 | MAP3K3 | 0.46564790 |
| 98 | CDK3 | 0.46032421 |
| 99 | RPS6KA5 | 0.45107744 |
| 100 | STK16 | 0.44839917 |
| 101 | OBSCN | 0.42475066 |
| 102 | DMPK | 0.42220694 |
| 103 | PDGFRA | 0.41420671 |
| 104 | CHUK | 0.40909402 |
| 105 | PIM2 | 0.39816134 |
| 106 | YES1 | 0.39053397 |
| 107 | FER | 0.38784868 |
| 108 | RPS6KB1 | 0.35725129 |
| 109 | ERBB4 | 0.35125187 |
| 110 | NEK6 | 0.34954681 |
| 111 | BRAF | 0.33022681 |
| 112 | CSNK1A1L | 0.32890974 |
| 113 | PRKDC | 0.32515372 |
| 114 | CSNK1G1 | 0.32105636 |
| 115 | CSNK1D | 0.30397524 |
| 116 | MAPK14 | 0.29795552 |
| 117 | MAP3K5 | 0.29063831 |
| 118 | FLT3 | 0.26789155 |
| 119 | CSNK1G3 | 0.26484578 |
| 120 | FGFR1 | 0.26413354 |
| 121 | MAP2K3 | 0.24340355 |
| 122 | AKT2 | 0.24235726 |
| 123 | CAMK1D | 0.23742218 |
| 124 | RAF1 | 0.23506590 |
| 125 | PAK1 | 0.23486249 |
| 126 | MAPK10 | 0.21882887 |
| 127 | TRPM7 | 0.20077096 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 4.80768267 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 4.65404287 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 3.91765854 |
| 4 | RNA transport_Homo sapiens_hsa03013 | 3.56100728 |
| 5 | Cell cycle_Homo sapiens_hsa04110 | 2.94542220 |
| 6 | DNA replication_Homo sapiens_hsa03030 | 2.83315709 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 2.57950553 |
| 8 | Spliceosome_Homo sapiens_hsa03040 | 2.56849589 |
| 9 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.43701996 |
| 10 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.26974248 |
| 11 | Basal transcription factors_Homo sapiens_hsa03022 | 2.20765895 |
| 12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.16533346 |
| 13 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.14353163 |
| 14 | Homologous recombination_Homo sapiens_hsa03440 | 2.14147825 |
| 15 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.97784008 |
| 16 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.85822038 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.85315768 |
| 18 | Proteasome_Homo sapiens_hsa03050 | 1.82695717 |
| 19 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.81203621 |
| 20 | Base excision repair_Homo sapiens_hsa03410 | 1.81002817 |
| 21 | RNA degradation_Homo sapiens_hsa03018 | 1.73638080 |
| 22 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.73066110 |
| 23 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.72705276 |
| 24 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.69703875 |
| 25 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.68964548 |
| 26 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.52218108 |
| 27 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.51131000 |
| 28 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.41091669 |
| 29 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.38687601 |
| 30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.33461921 |
| 31 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.31148543 |
| 32 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.30116378 |
| 33 | Purine metabolism_Homo sapiens_hsa00230 | 1.29184536 |
| 34 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.25751110 |
| 35 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.25522077 |
| 36 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.23600355 |
| 37 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.22243169 |
| 38 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.21442156 |
| 39 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.19113871 |
| 40 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.14484153 |
| 41 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.10521834 |
| 42 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.10124649 |
| 43 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.09861747 |
| 44 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.04920260 |
| 45 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.03781238 |
| 46 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.01783519 |
| 47 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.99349797 |
| 48 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.97492679 |
| 49 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.94171387 |
| 50 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.88854582 |
| 51 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.88468668 |
| 52 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.87926566 |
| 53 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.86488866 |
| 54 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.86167760 |
| 55 | Ribosome_Homo sapiens_hsa03010 | 0.84466141 |
| 56 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.83584556 |
| 57 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.82977512 |
| 58 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.82429050 |
| 59 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.80331042 |
| 60 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.77836428 |
| 61 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.76921836 |
| 62 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.76490466 |
| 63 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.74925648 |
| 64 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.73398240 |
| 65 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.72746275 |
| 66 | Thyroid cancer_Homo sapiens_hsa05216 | 0.69251041 |
| 67 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.66809428 |
| 68 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.64595055 |
| 69 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.63778192 |
| 70 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.62057918 |
| 71 | HTLV-I infection_Homo sapiens_hsa05166 | 0.58016811 |
| 72 | Prostate cancer_Homo sapiens_hsa05215 | 0.55609749 |
| 73 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.54667343 |
| 74 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.53979120 |
| 75 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.52183737 |
| 76 | Retinol metabolism_Homo sapiens_hsa00830 | 0.49827920 |
| 77 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.48727412 |
| 78 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.47565387 |
| 79 | Carbon metabolism_Homo sapiens_hsa01200 | 0.44844484 |
| 80 | Protein export_Homo sapiens_hsa03060 | 0.44759693 |
| 81 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.44313568 |
| 82 | Adherens junction_Homo sapiens_hsa04520 | 0.42335128 |
| 83 | Colorectal cancer_Homo sapiens_hsa05210 | 0.39448992 |
| 84 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.39057032 |
| 85 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.38632210 |
| 86 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.37419168 |
| 87 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.37405118 |
| 88 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.36808073 |
| 89 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.36696109 |
| 90 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.36621757 |
| 91 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.35784117 |
| 92 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.34583739 |
| 93 | Lysine degradation_Homo sapiens_hsa00310 | 0.34376266 |
| 94 | Legionellosis_Homo sapiens_hsa05134 | 0.34115122 |
| 95 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.33901461 |
| 96 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.32925934 |
| 97 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.32799519 |
| 98 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.31321138 |
| 99 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.31176244 |
| 100 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.30095510 |
| 101 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.29534562 |
| 102 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.28667134 |
| 103 | Hepatitis B_Homo sapiens_hsa05161 | 0.28638699 |
| 104 | Circadian rhythm_Homo sapiens_hsa04710 | 0.28557246 |
| 105 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.28204670 |
| 106 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.27668994 |
| 107 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.27382222 |
| 108 | Apoptosis_Homo sapiens_hsa04210 | 0.26623374 |
| 109 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.26310496 |
| 110 | Melanoma_Homo sapiens_hsa05218 | 0.26252259 |
| 111 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.26020632 |
| 112 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.25452652 |
| 113 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.25392982 |
| 114 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.25041330 |
| 115 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.24204555 |
| 116 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.23843676 |
| 117 | Sulfur relay system_Homo sapiens_hsa04122 | 0.21616721 |
| 118 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.20941885 |
| 119 | Influenza A_Homo sapiens_hsa05164 | 0.20909100 |
| 120 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.20801559 |
| 121 | Metabolic pathways_Homo sapiens_hsa01100 | 0.20770554 |
| 122 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.19553122 |
| 123 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.18090540 |
| 124 | Bladder cancer_Homo sapiens_hsa05219 | 0.16162312 |
| 125 | Measles_Homo sapiens_hsa05162 | 0.16048733 |
| 126 | Endometrial cancer_Homo sapiens_hsa05213 | 0.15482847 |
| 127 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.15268029 |
| 128 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.15266412 |
| 129 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.13582235 |
| 130 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.12732744 |
| 131 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.12060928 |
| 132 | Tight junction_Homo sapiens_hsa04530 | 0.11874228 |
| 133 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.11675392 |
| 134 | Pathways in cancer_Homo sapiens_hsa05200 | 0.11403070 |
| 135 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.10876320 |
| 136 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.08737579 |

