ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of DNA endoreduplication (GO:0032875)	5.11985992
2	resolution of meiotic recombination intermediates (GO:0000712)	4.46696870
3	piRNA metabolic process (GO:0034587)	4.37920116
4	centriole replication (GO:0007099)	4.17919054
5	neural tube formation (GO:0001841)	4.09113977
6	replication fork processing (GO:0031297)	4.06541947
7	indolalkylamine metabolic process (GO:0006586)	4.03626041
8	positive regulation of male gonad development (GO:2000020)	4.00288553
9	regulation of male gonad development (GO:2000018)	3.98471302
10	tryptophan metabolic process (GO:0006568)	3.95256345
11	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.92318631
12	DNA double-strand break processing (GO:0000729)	3.86327480
13	synapsis (GO:0007129)	3.86218868
14	somite development (GO:0061053)	3.85880396
15	dorsal/ventral axis specification (GO:0009950)	3.81276319
16	kynurenine metabolic process (GO:0070189)	3.78360867
17	negative regulation of axon guidance (GO:1902668)	3.71578082
18	atrial cardiac muscle cell action potential (GO:0086014)	3.61944452
19	response to pheromone (GO:0019236)	3.56791689
20	limb bud formation (GO:0060174)	3.41015769
21	embryonic foregut morphogenesis (GO:0048617)	3.40634118
22	prostate gland growth (GO:0060736)	3.40496753
23	tryptophan catabolic process (GO:0006569)	3.39772315
24	indole-containing compound catabolic process (GO:0042436)	3.39772315
25	indolalkylamine catabolic process (GO:0046218)	3.39772315
26	multicellular organism reproduction (GO:0032504)	3.35690683
27	meiotic chromosome segregation (GO:0045132)	3.31407155
28	mesonephros development (GO:0001823)	3.30387387
29	regulation of mesoderm development (GO:2000380)	3.27190966
30	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.17407037
31	mitotic sister chromatid cohesion (GO:0007064)	3.13806152
32	indole-containing compound metabolic process (GO:0042430)	3.11804810
33	regulation of mRNA 3-end processing (GO:0031440)	3.11763819
34	positive regulation of meiosis (GO:0045836)	3.10105501
35	male meiosis I (GO:0007141)	3.07979085
36	glomerulus development (GO:0032835)	3.07419053
37	cellular ketone body metabolic process (GO:0046950)	3.04183122
38	artery development (GO:0060840)	3.00125853
39	male meiosis (GO:0007140)	2.99930447
40	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.99691004
41	embryonic digestive tract morphogenesis (GO:0048557)	2.98671871
42	behavioral response to nicotine (GO:0035095)	2.98352589
43	double-strand break repair via homologous recombination (GO:0000724)	2.90910194
44	recombinational repair (GO:0000725)	2.87535087
45	chromosome organization involved in meiosis (GO:0070192)	2.87335280
46	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.87260883
47	detection of light stimulus involved in sensory perception (GO:0050962)	2.86196401
48	detection of light stimulus involved in visual perception (GO:0050908)	2.86196401
49	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.86102046
50	positive regulation of meiotic cell cycle (GO:0051446)	2.85491490
51	kinetochore organization (GO:0051383)	2.85305075
52	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.84431042
53	DNA methylation involved in gamete generation (GO:0043046)	2.82156433
54	prenylation (GO:0097354)	2.81939189
55	protein prenylation (GO:0018342)	2.81939189
56	protein K6-linked ubiquitination (GO:0085020)	2.81190256
57	hindbrain development (GO:0030902)	2.81056333
58	tachykinin receptor signaling pathway (GO:0007217)	2.79106367
59	lysine catabolic process (GO:0006554)	2.78587108
60	lysine metabolic process (GO:0006553)	2.78587108
61	ectoderm development (GO:0007398)	2.77123550
62	epithelial cilium movement (GO:0003351)	2.77106501
63	regulation of meiosis I (GO:0060631)	2.71696191
64	rRNA catabolic process (GO:0016075)	2.70075529
65	positive regulation of mRNA 3-end processing (GO:0031442)	2.67936859
66	microtubule nucleation (GO:0007020)	2.65605386
67	thalamus development (GO:0021794)	2.65169200
68	retinal ganglion cell axon guidance (GO:0031290)	2.64345791
69	ketone body metabolic process (GO:1902224)	2.63554513
70	reciprocal meiotic recombination (GO:0007131)	2.63379847
71	reciprocal DNA recombination (GO:0035825)	2.63379847
72	endoderm formation (GO:0001706)	2.61662900
73	platelet dense granule organization (GO:0060155)	2.60411275
74	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.59830343
75	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.59749179
76	axon extension involved in axon guidance (GO:0048846)	2.59749179
77	centriole assembly (GO:0098534)	2.55760577
78	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.55554176
79	histone-serine phosphorylation (GO:0035404)	2.54987689
80	oocyte development (GO:0048599)	2.54753885
81	pericardium development (GO:0060039)	2.53550866
82	regulation of female gonad development (GO:2000194)	2.52822514
83	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.52090777
84	microtubule depolymerization (GO:0007019)	2.51201939
85	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.50216751
86	fucose catabolic process (GO:0019317)	2.50213745
87	L-fucose metabolic process (GO:0042354)	2.50213745
88	L-fucose catabolic process (GO:0042355)	2.50213745
89	embryonic epithelial tube formation (GO:0001838)	2.49984256
90	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.49587799
91	otic vesicle formation (GO:0030916)	2.49184664
92	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.48661878
93	regulation of mitotic spindle checkpoint (GO:1903504)	2.48661878
94	histone H3-K9 demethylation (GO:0033169)	2.48608428
95	postreplication repair (GO:0006301)	2.48578090
96	pancreas development (GO:0031016)	2.47263084
97	lung lobe morphogenesis (GO:0060463)	2.45994295
98	inner ear receptor stereocilium organization (GO:0060122)	2.45834996
99	protein K48-linked deubiquitination (GO:0071108)	2.44486602
100	interkinetic nuclear migration (GO:0022027)	2.43194178

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.67477119
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.32072178
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.09410369
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.08730604
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.95620114
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69512587
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.64184466
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.61894817
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.56577965
10	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.46092162
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.31376300
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.29251915
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.26943060
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.25768958
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.21994656
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.20444461
17	EWS_26573619_Chip-Seq_HEK293_Human	2.19577113
18	P300_19829295_ChIP-Seq_ESCs_Human	2.18054981
19	EZH2_22144423_ChIP-Seq_EOC_Human	2.00718280
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.00035101
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.97712101
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.87906347
23	FUS_26573619_Chip-Seq_HEK293_Human	1.86163281
24	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.85336705
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.83008895
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79008412
27	STAT3_23295773_ChIP-Seq_U87_Human	1.71363912
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.69570393
29	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.65527272
30	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.65368188
31	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.64477912
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.64412661
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.63615339
34	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.61146596
35	TCF4_23295773_ChIP-Seq_U87_Human	1.57949283
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.57526760
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.57072983
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55599043
39	AR_25329375_ChIP-Seq_VCAP_Human	1.54636626
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54488816
41	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.52045953
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.51741695
43	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.51406280
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.47875694
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46335735
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.45256283
47	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.40980368
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38948017
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37407893
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.37407893
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.36777799
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.35063439
53	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.34654770
54	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.34313141
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33393162
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.30162216
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.29880914
58	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29870617
59	AR_21572438_ChIP-Seq_LNCaP_Human	1.29849728
60	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.27558493
61	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.24889269
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24351272
63	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24064446
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24015160
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24015160
66	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.23755516
67	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23595096
68	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23589186
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23493588
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.22661334
71	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18566733
72	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17425860
73	E2F7_22180533_ChIP-Seq_HELA_Human	1.15535775
74	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.15238712
75	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.14307176
76	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.13334694
77	P53_22387025_ChIP-Seq_ESCs_Mouse	1.12029854
78	RXR_22108803_ChIP-Seq_LS180_Human	1.11231097
79	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.11020027
80	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06834352
81	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.06804180
82	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.06090551
83	JUN_21703547_ChIP-Seq_K562_Human	1.05786618
84	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.05600291
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05037964
86	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.04759800
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03245009
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02359470
89	NCOR_22424771_ChIP-Seq_293T_Human	1.01927617
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.98792020
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98706860
92	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98295847
93	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.96658889
94	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.96415310
95	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96415310
96	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.96159306
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.96003644
98	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.95796391
99	CDX2_22108803_ChIP-Seq_LS180_Human	0.95470459
100	TP53_16413492_ChIP-PET_HCT116_Human	0.94957096

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003283_abnormal_digestive_organ	4.87966212
2	MP0008057_abnormal_DNA_replication	4.58399033
3	MP0008877_abnormal_DNA_methylation	3.39972854
4	MP0006292_abnormal_olfactory_placode	3.02436309
5	MP0006072_abnormal_retinal_apoptosis	2.95891439
6	MP0002102_abnormal_ear_morphology	2.93734809
7	MP0000569_abnormal_digit_pigmentation	2.88972943
8	MP0003646_muscle_fatigue	2.21249584
9	MP0006276_abnormal_autonomic_nervous	2.02892593
10	MP0003950_abnormal_plasma_membrane	2.02763269
11	MP0000383_abnormal_hair_follicle	2.02093849
12	MP0004215_abnormal_myocardial_fiber	2.01963662
13	MP0004885_abnormal_endolymph	1.99579778
14	MP0002837_dystrophic_cardiac_calcinosis	1.99568255
15	MP0003195_calcinosis	1.96729696
16	MP0002234_abnormal_pharynx_morphology	1.92668534
17	MP0005253_abnormal_eye_physiology	1.87436062
18	MP0000427_abnormal_hair_cycle	1.81949721
19	MP0005551_abnormal_eye_electrophysiolog	1.76105485
20	MP0004145_abnormal_muscle_electrophysio	1.67939827
21	MP0004742_abnormal_vestibular_system	1.65314375
22	MP0002751_abnormal_autonomic_nervous	1.58859359
23	MP0003880_abnormal_central_pattern	1.55356875
24	MP0003938_abnormal_ear_development	1.51439025
25	MP0003119_abnormal_digestive_system	1.47234741
26	MP0002822_catalepsy	1.46751389
27	MP0009046_muscle_twitch	1.44820410
28	MP0002736_abnormal_nociception_after	1.43715243
29	MP0003890_abnormal_embryonic-extraembry	1.40409265
30	MP0002160_abnormal_reproductive_system	1.38861151
31	MP0001929_abnormal_gametogenesis	1.37007299
32	MP0008058_abnormal_DNA_repair	1.32541581
33	MP0004043_abnormal_pH_regulation	1.31357595
34	MP0002210_abnormal_sex_determination	1.30162942
35	MP0008995_early_reproductive_senescence	1.29458846
36	MP0001968_abnormal_touch/_nociception	1.28716879
37	MP0009697_abnormal_copulation	1.27781708
38	MP0010094_abnormal_chromosome_stability	1.26560018
39	MP0002272_abnormal_nervous_system	1.23013294
40	MP0009745_abnormal_behavioral_response	1.22834332
41	MP0001501_abnormal_sleep_pattern	1.21455245
42	MP0005389_reproductive_system_phenotype	1.20920647
43	MP0003693_abnormal_embryo_hatching	1.20309433
44	MP0005410_abnormal_fertilization	1.16161023
45	MP0010678_abnormal_skin_adnexa	1.15928643
46	MP0001661_extended_life_span	1.14565274
47	MP0008875_abnormal_xenobiotic_pharmacok	1.14395104
48	MP0005386_behavior/neurological_phenoty	1.13579359
49	MP0004924_abnormal_behavior	1.13579359
50	MP0008775_abnormal_heart_ventricle	1.12179094
51	MP0000653_abnormal_sex_gland	1.12097491
52	MP0003787_abnormal_imprinting	1.11719050
53	MP0003698_abnormal_male_reproductive	1.11525349
54	MP0004142_abnormal_muscle_tone	1.09995684
55	MP0002557_abnormal_social/conspecific_i	1.07887987
56	MP0003937_abnormal_limbs/digits/tail_de	1.05979049
57	MP0000631_abnormal_neuroendocrine_gland	1.05395967
58	MP0004484_altered_response_of	1.03791450
59	MP0001145_abnormal_male_reproductive	1.02419730
60	MP0003567_abnormal_fetal_cardiomyocyte	1.01911545
61	MP0001764_abnormal_homeostasis	1.01554597
62	MP0003137_abnormal_impulse_conducting	0.99374770
63	MP0005266_abnormal_metabolism	0.97132154
64	MP0006036_abnormal_mitochondrial_physio	0.96275322
65	MP0003121_genomic_imprinting	0.94754626
66	MP0004085_abnormal_heartbeat	0.94691859
67	MP0000778_abnormal_nervous_system	0.94668163
68	MP0002067_abnormal_sensory_capabilities	0.93509457
69	MP0005391_vision/eye_phenotype	0.91810465
70	MP0004133_heterotaxia	0.91016370
71	MP0010386_abnormal_urinary_bladder	0.90028723
72	MP0001119_abnormal_female_reproductive	0.86665158
73	MP0000647_abnormal_sebaceous_gland	0.85619997
74	MP0006035_abnormal_mitochondrial_morpho	0.85608509
75	MP0001485_abnormal_pinna_reflex	0.84325131
76	MP0001486_abnormal_startle_reflex	0.84191596
77	MP0005195_abnormal_posterior_eye	0.83151494
78	MP0010368_abnormal_lymphatic_system	0.80436133
79	MP0005174_abnormal_tail_pigmentation	0.78644526
80	MP0002254_reproductive_system_inflammat	0.78601842
81	MP0002095_abnormal_skin_pigmentation	0.78359635
82	MP0001986_abnormal_taste_sensitivity	0.78316079
83	MP0002938_white_spotting	0.77725777
84	MP0001286_abnormal_eye_development	0.77699118
85	MP0002064_seizures	0.74338695
86	MP0005620_abnormal_muscle_contractility	0.73051960
87	MP0005376_homeostasis/metabolism_phenot	0.72903841
88	MP0003252_abnormal_bile_duct	0.71832886
89	MP0000015_abnormal_ear_pigmentation	0.71782472
90	MP0002229_neurodegeneration	0.71572519
91	MP0002572_abnormal_emotion/affect_behav	0.71413451
92	MP0000049_abnormal_middle_ear	0.70138912
93	MP0002282_abnormal_trachea_morphology	0.69802816
94	MP0002184_abnormal_innervation	0.68026895
95	MP0000470_abnormal_stomach_morphology	0.65867683
96	MP0001529_abnormal_vocalization	0.65486522
97	MP0001502_abnormal_circadian_rhythm	0.65036260
98	MP0003943_abnormal_hepatobiliary_system	0.64556699
99	MP0002752_abnormal_somatic_nervous	0.64509119
100	MP0003942_abnormal_urinary_system	0.64154091

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Volvulus (HP:0002580)	4.76214583
2	True hermaphroditism (HP:0010459)	4.62054840
3	Pancreatic fibrosis (HP:0100732)	4.11154417
4	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.90797220
5	Congenital stationary night blindness (HP:0007642)	3.56025403
6	Abnormality of the renal cortex (HP:0011035)	3.50286942
7	Pancreatic cysts (HP:0001737)	3.45717154
8	Molar tooth sign on MRI (HP:0002419)	3.44748053
9	Abnormality of midbrain morphology (HP:0002418)	3.44748053
10	Short tibia (HP:0005736)	3.31149196
11	Ectopic kidney (HP:0000086)	3.12368359
12	Oligodactyly (hands) (HP:0001180)	3.12149234
13	Tubulointerstitial fibrosis (HP:0005576)	2.91208744
14	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.87240815
15	Atonic seizures (HP:0010819)	2.81259674
16	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.78498245
17	Abnormality of the labia minora (HP:0012880)	2.71542735
18	Hyperventilation (HP:0002883)	2.70458682
19	Chromsome breakage (HP:0040012)	2.69485810
20	Intestinal atresia (HP:0011100)	2.66956164
21	Tented upper lip vermilion (HP:0010804)	2.63572049
22	Abnormality of lateral ventricle (HP:0030047)	2.59724021
23	Small hand (HP:0200055)	2.56118101
24	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.50188759
25	Abnormality of the renal medulla (HP:0100957)	2.50005420
26	Abnormality of chromosome stability (HP:0003220)	2.46847631
27	Cystic liver disease (HP:0006706)	2.44093374
28	Preaxial foot polydactyly (HP:0001841)	2.44010227
29	Male pseudohermaphroditism (HP:0000037)	2.43057496
30	Abnormality of the ileum (HP:0001549)	2.42133538
31	Attenuation of retinal blood vessels (HP:0007843)	2.40830093
32	Hypoplasia of the fovea (HP:0007750)	2.38272100
33	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.38272100
34	Anomalous pulmonary venous return (HP:0010772)	2.36694088
35	Tubulointerstitial abnormality (HP:0001969)	2.36560690
36	Nephronophthisis (HP:0000090)	2.36481689
37	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.33592737
38	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.33592737
39	Mesangial abnormality (HP:0001966)	2.31292856
40	Chronic hepatic failure (HP:0100626)	2.28170042
41	Small intestinal stenosis (HP:0012848)	2.27384622
42	Duodenal stenosis (HP:0100867)	2.27384622
43	Preaxial hand polydactyly (HP:0001177)	2.26501767
44	Meckel diverticulum (HP:0002245)	2.23944054
45	Gonadal dysgenesis (HP:0000133)	2.23140700
46	Renal cortical cysts (HP:0000803)	2.22911356
47	Fair hair (HP:0002286)	2.20596742
48	Hypothermia (HP:0002045)	2.20495436
49	Abnormal rod and cone electroretinograms (HP:0008323)	2.18179835
50	Polyuria (HP:0000103)	2.17555106
51	Central scotoma (HP:0000603)	2.16120178
52	Abnormality of the duodenum (HP:0002246)	2.11556831
53	Tubular atrophy (HP:0000092)	2.11372907
54	Abnormal drinking behavior (HP:0030082)	2.10248489
55	Polydipsia (HP:0001959)	2.10248489
56	Furrowed tongue (HP:0000221)	2.09036687
57	Anophthalmia (HP:0000528)	2.08182998
58	Abnormality of the preputium (HP:0100587)	2.04124131
59	Hypoplastic left heart (HP:0004383)	2.01393441
60	Sclerocornea (HP:0000647)	1.99490771
61	Abnormality of the pulmonary veins (HP:0011718)	1.99348434
62	Medial flaring of the eyebrow (HP:0010747)	1.99108959
63	Gaze-evoked nystagmus (HP:0000640)	1.97516597
64	Bilateral microphthalmos (HP:0007633)	1.97501773
65	Sloping forehead (HP:0000340)	1.96055814
66	Median cleft lip (HP:0000161)	1.95424609
67	Congenital, generalized hypertrichosis (HP:0004540)	1.95256375
68	Nephroblastoma (Wilms tumor) (HP:0002667)	1.94323799
69	Abnormal number of incisors (HP:0011064)	1.92379180
70	Oligodactyly (HP:0012165)	1.92333741
71	Hypoplastic ischia (HP:0003175)	1.89799807
72	Optic nerve hypoplasia (HP:0000609)	1.88327759
73	Postaxial foot polydactyly (HP:0001830)	1.87092514
74	Embryonal renal neoplasm (HP:0011794)	1.86852239
75	Absent speech (HP:0001344)	1.85714586
76	Abnormality of the corticospinal tract (HP:0002492)	1.85363724
77	Gastrointestinal atresia (HP:0002589)	1.85311943
78	Abnormality of DNA repair (HP:0003254)	1.82664034
79	Oligohydramnios (HP:0001562)	1.82603527
80	Astigmatism (HP:0000483)	1.82036148
81	Highly arched eyebrow (HP:0002553)	1.81168308
82	Broad-based gait (HP:0002136)	1.80283825
83	Abnormality of urine glucose concentration (HP:0011016)	1.80049125
84	Glycosuria (HP:0003076)	1.80049125
85	Fibular hypoplasia (HP:0003038)	1.79338247
86	Abnormality of the fovea (HP:0000493)	1.76522248
87	Albinism (HP:0001022)	1.75588925
88	Type II lissencephaly (HP:0007260)	1.75276089
89	Absence seizures (HP:0002121)	1.74991370
90	Clubbing of toes (HP:0100760)	1.72766098
91	Abnormality of the incisor (HP:0000676)	1.72206416
92	Abnormality of the renal collecting system (HP:0004742)	1.72065018
93	Metabolic alkalosis (HP:0200114)	1.71528417
94	Duplicated collecting system (HP:0000081)	1.71484313
95	Triphalangeal thumb (HP:0001199)	1.71401233
96	Birth length less than 3rd percentile (HP:0003561)	1.68590572
97	Protruding tongue (HP:0010808)	1.67866299
98	Severe visual impairment (HP:0001141)	1.67557907
99	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.66054827
100	Abnormality of incisor morphology (HP:0011063)	1.65462731

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.84611762
2	ACVR1B	4.33660928
3	BMPR1B	3.35392343
4	CASK	3.16440586
5	NUAK1	3.10042429
6	TAOK3	2.49533540
7	TLK1	2.29753512
8	ZAK	2.11473109
9	STK16	2.11426600
10	ADRBK2	2.09693574
11	TNIK	2.01327648
12	NTRK3	1.83737489
13	OBSCN	1.81845821
14	LATS1	1.80181464
15	EPHA4	1.77877700
16	BRSK2	1.61870944
17	STK3	1.60160140
18	STK39	1.49707379
19	OXSR1	1.47843703
20	PINK1	1.46676597
21	GRK1	1.41322736
22	CDK19	1.35461624
23	WNK4	1.28634362
24	PLK4	1.28391980
25	MAPK13	1.26728427
26	WNK3	1.26546107
27	PNCK	1.25790272
28	GRK5	1.24392797
29	TGFBR1	1.22883838
30	MAP3K4	1.21520604
31	MAP3K7	1.19461923
32	MKNK2	1.17131827
33	PRKCE	1.03867688
34	BRD4	0.98675093
35	PAK3	0.98649778
36	PLK1	0.94769573
37	WEE1	0.91019495
38	NLK	0.89030085
39	ADRBK1	0.87044618
40	RAF1	0.86855907
41	PTK2B	0.81507420
42	CSNK1G1	0.81305202
43	MARK1	0.80886326
44	GRK7	0.80003467
45	INSRR	0.77727129
46	TRIM28	0.76466387
47	CDK3	0.76127612
48	PHKG2	0.74793519
49	PHKG1	0.74793519
50	ERBB3	0.74433732
51	SGK2	0.73668886
52	MAP2K6	0.72663857
53	PLK3	0.72065126
54	PKN1	0.71678267
55	IRAK1	0.69931315
56	PLK2	0.68170685
57	CHEK2	0.66683596
58	VRK1	0.66450389
59	AURKB	0.65303235
60	ATR	0.59921742
61	TTK	0.59322521
62	MAPKAPK3	0.58868963
63	CDC7	0.58470588
64	AURKA	0.56872232
65	BRSK1	0.56531581
66	CDK8	0.56291166
67	CAMK2A	0.55204021
68	MELK	0.54844383
69	CDK4	0.54742909
70	CAMK4	0.54341340
71	ATM	0.52719815
72	MYLK	0.51731691
73	SGK1	0.48041917
74	PRKCG	0.45340173
75	DAPK2	0.45208082
76	NEK1	0.44823875
77	TSSK6	0.44179176
78	TIE1	0.43920189
79	MARK3	0.43689797
80	MAP2K1	0.43037367
81	KSR1	0.42289410
82	STK4	0.42048818
83	PRKACA	0.40899348
84	CAMK1	0.39684991
85	MAP3K2	0.39071889
86	GRK6	0.38880023
87	TRPM7	0.37149295
88	MKNK1	0.36783850
89	TEC	0.35254337
90	NEK2	0.33351791
91	CSNK1G2	0.32841076
92	FER	0.32799977
93	STK38L	0.32706322
94	PRKDC	0.32430221
95	MAP2K7	0.32034547
96	CHEK1	0.31759280
97	PRKAA2	0.31704577
98	CSNK1E	0.31487582
99	CSNK1G3	0.31226707
100	PRKG1	0.30913701

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Tryptophan metabolism_Homo sapiens_hsa00380	2.83880841
2	Fanconi anemia pathway_Homo sapiens_hsa03460	2.82836449
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.66739803
4	Butanoate metabolism_Homo sapiens_hsa00650	2.58869070
5	Protein export_Homo sapiens_hsa03060	2.28740571
6	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.19930590
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.15006578
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.06524046
9	Homologous recombination_Homo sapiens_hsa03440	2.03545845
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.00142802
11	Phototransduction_Homo sapiens_hsa04744	1.87278241
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.79483370
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.68245432
14	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.68169041
15	Propanoate metabolism_Homo sapiens_hsa00640	1.62945259
16	Sulfur relay system_Homo sapiens_hsa04122	1.60480987
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.60018598
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59880429
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.54529750
20	Lysine degradation_Homo sapiens_hsa00310	1.51578103
21	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.50591323
22	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.46529122
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.44337095
24	Caffeine metabolism_Homo sapiens_hsa00232	1.43980491
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.43912141
26	Mismatch repair_Homo sapiens_hsa03430	1.43399383
27	One carbon pool by folate_Homo sapiens_hsa00670	1.43194606
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.39216760
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.32852669
30	RNA degradation_Homo sapiens_hsa03018	1.32008219
31	Nicotine addiction_Homo sapiens_hsa05033	1.30714649
32	ABC transporters_Homo sapiens_hsa02010	1.27925389
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.24813799
34	Serotonergic synapse_Homo sapiens_hsa04726	1.24079935
35	RNA polymerase_Homo sapiens_hsa03020	1.23580369
36	Fatty acid elongation_Homo sapiens_hsa00062	1.23560041
37	Morphine addiction_Homo sapiens_hsa05032	1.20415632
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.12627386
39	Basal transcription factors_Homo sapiens_hsa03022	1.12445832
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.12412168
41	Olfactory transduction_Homo sapiens_hsa04740	1.10789896
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.08962777
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.08947677
44	Taste transduction_Homo sapiens_hsa04742	1.07591343
45	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.06982163
46	Nitrogen metabolism_Homo sapiens_hsa00910	1.05703720
47	Retinol metabolism_Homo sapiens_hsa00830	1.04293103
48	Insulin secretion_Homo sapiens_hsa04911	1.04192251
49	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03888223
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02057687
51	GABAergic synapse_Homo sapiens_hsa04727	1.00387285
52	Basal cell carcinoma_Homo sapiens_hsa05217	1.00330522
53	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.00141011
54	Fatty acid degradation_Homo sapiens_hsa00071	0.97808104
55	Oxidative phosphorylation_Homo sapiens_hsa00190	0.97565710
56	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.95196734
57	Circadian entrainment_Homo sapiens_hsa04713	0.93682946
58	Oocyte meiosis_Homo sapiens_hsa04114	0.84285851
59	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.83865180
60	DNA replication_Homo sapiens_hsa03030	0.83197863
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.82332295
62	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.81697259
63	Parkinsons disease_Homo sapiens_hsa05012	0.81301804
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.79441471
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.77779838
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76854582
67	Calcium signaling pathway_Homo sapiens_hsa04020	0.76769447
68	Huntingtons disease_Homo sapiens_hsa05016	0.76278395
69	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75717351
70	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.75624079
71	RNA transport_Homo sapiens_hsa03013	0.75125294
72	Glutamatergic synapse_Homo sapiens_hsa04724	0.73832411
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.73707301
74	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.69326300
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67800797
76	Renin secretion_Homo sapiens_hsa04924	0.67045926
77	Hippo signaling pathway_Homo sapiens_hsa04390	0.63135000
78	Folate biosynthesis_Homo sapiens_hsa00790	0.62676175
79	Peroxisome_Homo sapiens_hsa04146	0.61627251
80	Fatty acid metabolism_Homo sapiens_hsa01212	0.60178595
81	Purine metabolism_Homo sapiens_hsa00230	0.56720697
82	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.56711243
83	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.54427781
84	Nucleotide excision repair_Homo sapiens_hsa03420	0.54114327
85	Cholinergic synapse_Homo sapiens_hsa04725	0.53850325
86	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.53180498
87	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.50830155
88	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50168301
89	Fat digestion and absorption_Homo sapiens_hsa04975	0.48502632
90	Salivary secretion_Homo sapiens_hsa04970	0.47608960
91	Alzheimers disease_Homo sapiens_hsa05010	0.47230709
92	Metabolic pathways_Homo sapiens_hsa01100	0.46531234
93	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.45994739
94	Long-term depression_Homo sapiens_hsa04730	0.45930506
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.45641595
96	Pyrimidine metabolism_Homo sapiens_hsa00240	0.45518878
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.45464082
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.44752201
99	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.44496368
100	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.43002011

LARP4P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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