LARP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.09168619
2central nervous system myelination (GO:0022010)8.09168619
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.58320275
4fatty acid elongation (GO:0030497)4.84430128
5myelination (GO:0042552)4.75993414
6axon ensheathment (GO:0008366)4.74448136
7ensheathment of neurons (GO:0007272)4.74448136
8neuron cell-cell adhesion (GO:0007158)4.52255402
9long-chain fatty acid biosynthetic process (GO:0042759)4.50577236
10negative regulation of neurotransmitter transport (GO:0051589)4.39962527
11presynaptic membrane organization (GO:0097090)4.32216505
12neuronal action potential propagation (GO:0019227)4.28452129
13negative regulation of neurotransmitter secretion (GO:0046929)4.14771781
14presynaptic membrane assembly (GO:0097105)4.05866569
15establishment of mitochondrion localization (GO:0051654)4.00829048
16synaptic vesicle maturation (GO:0016188)4.00208731
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.73696873
18synaptic vesicle exocytosis (GO:0016079)3.72595128
19myelin maintenance (GO:0043217)3.65518916
20vocalization behavior (GO:0071625)3.65333795
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.65250542
22cellular potassium ion homeostasis (GO:0030007)3.61406659
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.55852247
24protein heterotrimerization (GO:0070208)3.54200763
25neuron recognition (GO:0008038)3.53964263
26regulation of short-term neuronal synaptic plasticity (GO:0048172)3.52761040
27response to methylmercury (GO:0051597)3.51552643
28transmission of nerve impulse (GO:0019226)3.50879372
29L-amino acid import (GO:0043092)3.50092544
30negative regulation of protein localization to cell surface (GO:2000009)3.48123307
31regulation of synaptic vesicle exocytosis (GO:2000300)3.43654050
32protein localization to synapse (GO:0035418)3.42074448
33adult walking behavior (GO:0007628)3.37545967
34glutamate secretion (GO:0014047)3.36413117
35regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.36055938
36locomotory exploration behavior (GO:0035641)3.33196206
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.26070024
38cerebellar granule cell differentiation (GO:0021707)3.24916009
39glutamate receptor signaling pathway (GO:0007215)3.24774347
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.21367893
41kidney mesenchyme development (GO:0072074)3.18136221
42axonal fasciculation (GO:0007413)3.16875244
43oligodendrocyte differentiation (GO:0048709)3.15775847
44sodium ion export (GO:0071436)3.15196821
45response to gravity (GO:0009629)3.13486059
46dendritic spine morphogenesis (GO:0060997)3.13094829
47apical protein localization (GO:0045176)3.12930765
48neuron-neuron synaptic transmission (GO:0007270)3.09061225
49negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.08775846
50regulation of collateral sprouting (GO:0048670)3.08307700
51negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07080709
52synaptic transmission, glutamatergic (GO:0035249)3.05000179
53neuron remodeling (GO:0016322)3.04285728
54regulation of neuronal synaptic plasticity (GO:0048168)3.04272274
55gamma-aminobutyric acid transport (GO:0015812)3.03442817
56regulation of glutamate secretion (GO:0014048)3.03161112
57neuronal ion channel clustering (GO:0045161)3.01143307
58cerebral cortex radially oriented cell migration (GO:0021799)2.94564433
59substantia nigra development (GO:0021762)2.93985748
60glycine transport (GO:0015816)2.93478096
61glycerophospholipid catabolic process (GO:0046475)2.91018179
62asymmetric protein localization (GO:0008105)2.90814667
63negative regulation of axonogenesis (GO:0050771)2.88324128
64regulation of synaptic vesicle transport (GO:1902803)2.88086863
65regulation of glutamate receptor signaling pathway (GO:1900449)2.87127020
66collagen fibril organization (GO:0030199)2.85292070
67regulation of excitatory postsynaptic membrane potential (GO:0060079)2.84648095
68astrocyte development (GO:0014002)2.80962593
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80119811
70photoreceptor cell differentiation (GO:0046530)2.79466815
71eye photoreceptor cell differentiation (GO:0001754)2.79466815
72peptidyl-tyrosine autophosphorylation (GO:0038083)2.77722735
73axon extension (GO:0048675)2.77243828
74neurotransmitter uptake (GO:0001504)2.76358769
75mating behavior (GO:0007617)2.75586858
76positive regulation of membrane potential (GO:0045838)2.74867500
77regulation of long-term neuronal synaptic plasticity (GO:0048169)2.74617613
78regulation of dendritic spine morphogenesis (GO:0061001)2.74457383
79membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72822809
80nerve growth factor signaling pathway (GO:0038180)2.72790103
81extracellular matrix assembly (GO:0085029)2.72558862
82chondrocyte proliferation (GO:0035988)2.70488648
83exploration behavior (GO:0035640)2.69500177
84regulation of postsynaptic membrane potential (GO:0060078)2.69240849
85long-term memory (GO:0007616)2.68800422
86regulation of voltage-gated calcium channel activity (GO:1901385)2.67370317
87positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.67247965
88long-term synaptic potentiation (GO:0060291)2.66874199
89amino acid import (GO:0043090)2.64200455
90skin morphogenesis (GO:0043589)2.64007021
91cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.63547210
92detection of temperature stimulus involved in sensory perception (GO:0050961)2.63525964
93detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.63525964
94neurotransmitter secretion (GO:0007269)2.63288844
95bone trabecula formation (GO:0060346)2.63202402
96regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.63114157
97metanephric mesenchyme development (GO:0072075)2.63073874
98negative regulation of amino acid transport (GO:0051956)2.63008328
99mesenchymal-epithelial cell signaling (GO:0060638)2.62265214
100negative regulation of synaptic transmission (GO:0050805)2.61799602
101membrane hyperpolarization (GO:0060081)2.61406007
102layer formation in cerebral cortex (GO:0021819)2.60715361
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.60116113
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.59667562
105regulation of dendritic spine development (GO:0060998)2.59638381
106dendrite morphogenesis (GO:0048813)2.59606166
107neurotransmitter transport (GO:0006836)2.57668558
108regulation of dopamine metabolic process (GO:0042053)2.57462565
109regulation of catecholamine metabolic process (GO:0042069)2.57462565
110neuromuscular process controlling posture (GO:0050884)2.56124057
111positive regulation of synapse assembly (GO:0051965)2.56060172
112cholesterol biosynthetic process (GO:0006695)2.54042100
113negative regulation of axon extension (GO:0030517)2.53716271
114regulation of synaptic plasticity (GO:0048167)2.53505219
115postsynaptic membrane organization (GO:0001941)2.53419042
116cell communication by electrical coupling (GO:0010644)2.53108530
117peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.52796133
118dermatan sulfate biosynthetic process (GO:0030208)2.52295426
119mitochondrion transport along microtubule (GO:0047497)2.52024148
120establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.52024148
121protein retention in ER lumen (GO:0006621)2.51957357
122peripheral nervous system axon ensheathment (GO:0032292)2.49532312
123myelination in peripheral nervous system (GO:0022011)2.49532312
124endodermal cell differentiation (GO:0035987)2.47221194
125neuron projection extension (GO:1990138)2.45827924
126membrane assembly (GO:0071709)2.42576763
127cytoskeletal anchoring at plasma membrane (GO:0007016)2.40436851
128regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.39290074
129maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.39031907
130dermatan sulfate metabolic process (GO:0030205)2.34686825
131cell migration involved in heart development (GO:0060973)2.33933074
132response to redox state (GO:0051775)2.33600204
133positive regulation of dendritic spine development (GO:0060999)2.32518337
134cerebellar Purkinje cell layer development (GO:0021680)2.32373714
135axon extension involved in axon guidance (GO:0048846)2.32008059
136neuron projection extension involved in neuron projection guidance (GO:1902284)2.32008059
137neuromuscular process controlling balance (GO:0050885)2.31080595
138potassium ion homeostasis (GO:0055075)2.30746041
139positive regulation of axon extension (GO:0045773)2.27424569
140peptidyl-proline hydroxylation (GO:0019511)2.22589138
141regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.21619546
142negative regulation of catenin import into nucleus (GO:0035414)2.20573316
143type B pancreatic cell proliferation (GO:0044342)2.19932944
144potassium ion import (GO:0010107)2.19919736
145sequestering of extracellular ligand from receptor (GO:0035581)2.19514892
146protein targeting to plasma membrane (GO:0072661)2.16746913
147regulation of axon extension involved in axon guidance (GO:0048841)2.13961486
148extracellular fibril organization (GO:0043206)2.11912897
149regulation of neurotransmitter secretion (GO:0046928)2.11875992
150detection of calcium ion (GO:0005513)2.11509370
151relaxation of smooth muscle (GO:0044557)2.11017300
152paraxial mesoderm development (GO:0048339)2.10865857
153positive regulation of neurotransmitter transport (GO:0051590)2.09953322
154synaptic vesicle endocytosis (GO:0048488)2.09370115
155positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.09124487
156positive regulation of synapse maturation (GO:0090129)2.07063014
157cellular response to vitamin (GO:0071295)2.05075209

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.59582770
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.68290057
3GBX2_23144817_ChIP-Seq_PC3_Human3.58541558
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.03875158
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93227677
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89234906
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85123419
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.64668030
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55644461
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55644461
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40508014
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.40183725
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40043451
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39900164
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37622686
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36271395
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32666367
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.26256927
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25262997
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17107320
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.13906856
22TAF15_26573619_Chip-Seq_HEK293_Human2.10635750
23DROSHA_22980978_ChIP-Seq_HELA_Human2.02777542
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.02351156
25* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.01209969
26AR_21572438_ChIP-Seq_LNCaP_Human1.98104379
27REST_21632747_ChIP-Seq_MESCs_Mouse1.96318917
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95020988
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.87098633
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83631240
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71304005
32* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.70675411
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68589819
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68176713
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.66373280
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65848075
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.60239870
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56245052
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53076704
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52473216
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51651408
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50185830
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.49113034
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48309090
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.47690974
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.46033315
47KDM2B_26808549_Chip-Seq_K562_Human1.44736947
48VDR_22108803_ChIP-Seq_LS180_Human1.44499283
49P300_19829295_ChIP-Seq_ESCs_Human1.44022421
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43752672
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42788294
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42400278
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42137371
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41490645
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41015812
56SMAD4_21799915_ChIP-Seq_A2780_Human1.38874518
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36725699
58* TET1_21490601_ChIP-Seq_MESCs_Mouse1.35556111
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.35393285
60OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.34292815
61ER_23166858_ChIP-Seq_MCF-7_Human1.33597776
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32171408
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31771948
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.31709352
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31372440
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30970135
67TP53_23651856_ChIP-Seq_MEFs_Mouse1.28039540
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26304980
69CJUN_26792858_Chip-Seq_BT549_Human1.25856469
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25443586
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24372148
72* CTCF_27219007_Chip-Seq_Bcells_Human1.23908491
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22992126
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20871349
75STAT3_23295773_ChIP-Seq_U87_Human1.19333697
76* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19194526
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18316925
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.18177512
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17450789
80BRD4_25478319_ChIP-Seq_HGPS_Human1.16814180
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15199627
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.15174206
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12766486
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12696653
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12685070
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11889781
87STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11767259
88EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09449028
89RNF2_27304074_Chip-Seq_NSC_Mouse1.09314429
90* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08278781
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.07848641
92ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07588316
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07359767
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.06850979
95FUS_26573619_Chip-Seq_HEK293_Human1.05823884
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05626053
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05135221
98TP53_22127205_ChIP-Seq_IMR90_Human1.04952765
99WT1_19549856_ChIP-ChIP_CCG9911_Human1.04914085
100TCF4_23295773_ChIP-Seq_U87_Human1.04865494
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.04514333
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04169076
103ZNF274_21170338_ChIP-Seq_K562_Hela1.03780058
104AR_25329375_ChIP-Seq_VCAP_Human1.03778054
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.01862758
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.00724202
107ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99227289
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99127788
109P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99100882
110AHR_22903824_ChIP-Seq_MCF-7_Human0.98707584
111RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97245277
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97023652
113* RUNX2_22187159_ChIP-Seq_PCA_Human0.96828818
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96517816
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95130848
116EP300_21415370_ChIP-Seq_HL-1_Mouse0.95126192
117SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94344626
118CMYC_18555785_Chip-Seq_ESCs_Mouse0.93658665
119SA1_22415368_ChIP-Seq_MEFs_Mouse0.92968155
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92473953
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91790254
122TP53_18474530_ChIP-ChIP_U2OS_Human0.90276353
123TP53_16413492_ChIP-PET_HCT116_Human0.90100470
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90017881
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89616165
126KDM2B_26808549_Chip-Seq_REH_Human0.88870071
127GATA1_26923725_Chip-Seq_HPCs_Mouse0.88082350
128LXR_22292898_ChIP-Seq_THP-1_Human0.87938767
129SMAD4_21741376_ChIP-Seq_EPCs_Human0.87605549
130SMC1_22415368_ChIP-Seq_MEFs_Mouse0.87005642
131JUN_21703547_ChIP-Seq_K562_Human0.86799004
132IGF1R_20145208_ChIP-Seq_DFB_Human0.86560747
133ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86169228
134CLOCK_20551151_ChIP-Seq_293T_Human0.86121949
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86032749
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86032749
137ISL1_27105846_Chip-Seq_CPCs_Mouse0.85757025
138TAL1_26923725_Chip-Seq_HPCs_Mouse0.84826745
139EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84496224
140AR_19668381_ChIP-Seq_PC3_Human0.84250869
141DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83726488
142NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83528122
143SUZ12_18555785_Chip-Seq_ESCs_Mouse0.82800028
144CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81772700
145YAP1_20516196_ChIP-Seq_MESCs_Mouse0.81049255
146MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.80652421
147* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79435822
148SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78129949
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78003519
150SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.77341649
151DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.76788695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.09102938
2MP0008438_abnormal_cutaneous_collagen4.55677819
3MP0004859_abnormal_synaptic_plasticity4.45957823
4MP0004270_analgesia3.76864325
5MP0000920_abnormal_myelination3.46080020
6MP0003635_abnormal_synaptic_transmissio3.27736417
7MP0002064_seizures2.96506973
8MP0002272_abnormal_nervous_system2.92773960
9MP0005503_abnormal_tendon_morphology2.91288202
10MP0009745_abnormal_behavioral_response2.88576989
11MP0009046_muscle_twitch2.78467535
12MP0001486_abnormal_startle_reflex2.69246672
13MP0003329_amyloid_beta_deposits2.68411779
14MP0004272_abnormal_basement_membrane2.55521103
15MP0002063_abnormal_learning/memory/cond2.53922402
16MP0003705_abnormal_hypodermis_morpholog2.52666491
17MP0005423_abnormal_somatic_nervous2.52538906
18MP0002734_abnormal_mechanical_nocicepti2.41643335
19MP0001958_emphysema2.40420800
20MP0001529_abnormal_vocalization2.34519191
21MP0002572_abnormal_emotion/affect_behav2.30378487
22MP0003279_aneurysm2.27964756
23MP0005275_abnormal_skin_tensile2.25149164
24MP0001968_abnormal_touch/_nociception2.19532266
25MP0000778_abnormal_nervous_system2.19064174
26MP0004885_abnormal_endolymph2.18308229
27MP0001905_abnormal_dopamine_level2.07935340
28MP0010368_abnormal_lymphatic_system2.07799626
29MP0004142_abnormal_muscle_tone2.05547931
30MP0002735_abnormal_chemical_nociception2.03350950
31MP0001440_abnormal_grooming_behavior2.01779963
32MP0004742_abnormal_vestibular_system1.98285108
33MP0003690_abnormal_glial_cell1.94468364
34MP0001970_abnormal_pain_threshold1.87572193
35MP0008569_lethality_at_weaning1.85815342
36MP0010030_abnormal_orbit_morphology1.84970094
37MP0005257_abnormal_intraocular_pressure1.84094806
38MP0002067_abnormal_sensory_capabilities1.80173249
39MP0002733_abnormal_thermal_nociception1.75371793
40MP0005171_absent_coat_pigmentation1.73633287
41MP0002736_abnormal_nociception_after1.71619486
42MP0003634_abnormal_glial_cell1.70253897
43MP0001501_abnormal_sleep_pattern1.69505752
44MP0000955_abnormal_spinal_cord1.68935741
45MP0003950_abnormal_plasma_membrane1.63506971
46MP0002822_catalepsy1.63053835
47MP0005386_behavior/neurological_phenoty1.58658363
48MP0004924_abnormal_behavior1.58658363
49MP0009384_cardiac_valve_regurgitation1.55363448
50MP0005409_darkened_coat_color1.54158215
51MP0002882_abnormal_neuron_morphology1.52654331
52MP0002229_neurodegeneration1.51852232
53MP0006276_abnormal_autonomic_nervous1.49829049
54MP0002184_abnormal_innervation1.49801907
55MP0002066_abnormal_motor_capabilities/c1.48443709
56MP0001485_abnormal_pinna_reflex1.45432563
57MP0001542_abnormal_bone_strength1.43702814
58MP0003631_nervous_system_phenotype1.42316059
59MP0005410_abnormal_fertilization1.41914941
60MP0003633_abnormal_nervous_system1.41373019
61MP0003632_abnormal_nervous_system1.41173155
62MP0003283_abnormal_digestive_organ1.41118423
63MP0009250_abnormal_appendicular_skeleto1.34237056
64MP0000749_muscle_degeneration1.33359260
65MP0003136_yellow_coat_color1.33340199
66MP0002557_abnormal_social/conspecific_i1.32652077
67MP0005508_abnormal_skeleton_morphology1.30676800
68MP0000604_amyloidosis1.29692983
69MP0000534_abnormal_ureter_morphology1.29120222
70MP0004811_abnormal_neuron_physiology1.24676511
71MP0010386_abnormal_urinary_bladder1.21715197
72MP0004145_abnormal_muscle_electrophysio1.20899339
73MP0003942_abnormal_urinary_system1.19856930
74MP0000762_abnormal_tongue_morphology1.19645875
75MP0004858_abnormal_nervous_system1.16840501
76MP0005551_abnormal_eye_electrophysiolog1.16136034
77MP0001502_abnormal_circadian_rhythm1.15248205
78MP0002108_abnormal_muscle_morphology1.14017625
79MP0009053_abnormal_anal_canal1.13330636
80MP0009780_abnormal_chondrocyte_physiolo1.11920850
81MP0005645_abnormal_hypothalamus_physiol1.10547648
82MP0001963_abnormal_hearing_physiology1.09346860
83MP0001879_abnormal_lymphatic_vessel1.09254966
84MP0003566_abnormal_cell_adhesion1.08218001
85MP0002752_abnormal_somatic_nervous1.07580185
86MP0003385_abnormal_body_wall1.07349517
87MP0005623_abnormal_meninges_morphology1.05925910
88MP0002152_abnormal_brain_morphology1.03522056
89MP0004043_abnormal_pH_regulation1.01443603
90MP0000049_abnormal_middle_ear1.01327835
91MP0005595_abnormal_vascular_smooth0.97371399
92MP0000537_abnormal_urethra_morphology0.96356579
93MP0005670_abnormal_white_adipose0.95388190
94MP0000462_abnormal_digestive_system0.93969318
95MP0001299_abnormal_eye_distance/0.93136202
96MP0001177_atelectasis0.92239847
97MP0000747_muscle_weakness0.92234962
98MP0002234_abnormal_pharynx_morphology0.92231106
99MP0002896_abnormal_bone_mineralization0.90710264
100MP0008260_abnormal_autophagy0.89447057
101MP0000428_abnormal_craniofacial_morphol0.88538061
102MP0004084_abnormal_cardiac_muscle0.87996219
103MP0005646_abnormal_pituitary_gland0.87571931
104MP0004134_abnormal_chest_morphology0.86852486
105MP0000759_abnormal_skeletal_muscle0.86828897
106MP0005023_abnormal_wound_healing0.85979291
107MP0003941_abnormal_skin_development0.84019684
108MP0000751_myopathy0.83715853
109MP0002249_abnormal_larynx_morphology0.83340920
110MP0000767_abnormal_smooth_muscle0.80601873
111MP0001984_abnormal_olfaction0.79888408
112MP0009379_abnormal_foot_pigmentation0.79818640
113MP0003755_abnormal_palate_morphology0.77659938
114MP0000733_abnormal_muscle_development0.77213197
115MP0001188_hyperpigmentation0.76846216
116MP0002069_abnormal_eating/drinking_beha0.75512779
117MP0003879_abnormal_hair_cell0.75037519
118MP0004233_abnormal_muscle_weight0.73513139
119MP0000163_abnormal_cartilage_morphology0.72356291
120MP0000003_abnormal_adipose_tissue0.72107941
121MP0003137_abnormal_impulse_conducting0.71775611
122MP0002060_abnormal_skin_morphology0.71724885
123MP0004085_abnormal_heartbeat0.71249264
124MP0003122_maternal_imprinting0.71068429
125MP0001348_abnormal_lacrimal_gland0.70665602
126MP0003123_paternal_imprinting0.70170855
127MP0008874_decreased_physiological_sensi0.68716108
128MP0010678_abnormal_skin_adnexa0.68329863
129MP0000013_abnormal_adipose_tissue0.67330238
130MP0000631_abnormal_neuroendocrine_gland0.65673440
131MP0000026_abnormal_inner_ear0.65646939
132MP0005195_abnormal_posterior_eye0.63077563
133MP0003938_abnormal_ear_development0.62401770
134MP0003787_abnormal_imprinting0.62011876
135MP0003075_altered_response_to0.60906197
136MP0004381_abnormal_hair_follicle0.60883250
137MP0002837_dystrophic_cardiac_calcinosis0.60713976
138MP0001943_abnormal_respiration0.60473397
139MP0004036_abnormal_muscle_relaxation0.59412893
140MP0002090_abnormal_vision0.59002004
141MP0001664_abnormal_digestion0.57659385
142MP0001346_abnormal_lacrimal_gland0.57650439
143MP0003861_abnormal_nervous_system0.51974397
144MP0004147_increased_porphyrin_level0.51537113
145MP0002295_abnormal_pulmonary_circulatio0.50131345
146MP0008872_abnormal_physiological_respon0.49342432

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.83110494
2Protrusio acetabuli (HP:0003179)5.55879116
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.55016571
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.55016571
5Premature rupture of membranes (HP:0001788)5.47681830
6Myokymia (HP:0002411)5.06739293
7Focal motor seizures (HP:0011153)4.77730125
8Cerebral inclusion bodies (HP:0100314)4.72273120
9Abnormality of the corticospinal tract (HP:0002492)4.54683032
10Supranuclear gaze palsy (HP:0000605)4.49478365
11Peripheral hypomyelination (HP:0007182)3.79979721
12Ankle clonus (HP:0011448)3.70661055
13Dysmetria (HP:0001310)3.66509265
14Spastic gait (HP:0002064)3.59875443
15Focal seizures (HP:0007359)3.59799409
16Sensory axonal neuropathy (HP:0003390)3.43979127
17Insidious onset (HP:0003587)3.41597342
18Termporal pattern (HP:0011008)3.41597342
19Aortic dissection (HP:0002647)3.38151733
20Ankle contracture (HP:0006466)3.36937018
21Bladder diverticulum (HP:0000015)3.35975072
22Cerebral hypomyelination (HP:0006808)3.35021024
23Vascular tortuosity (HP:0004948)3.31241824
24Aortic aneurysm (HP:0004942)3.29956959
25Shallow orbits (HP:0000586)3.29604364
26Atonic seizures (HP:0010819)3.28361209
27Atrophic scars (HP:0001075)3.23550045
28Onion bulb formation (HP:0003383)3.21785613
29Spinal rigidity (HP:0003306)3.21405797
30Type 1 muscle fiber predominance (HP:0003803)3.21221271
31Intention tremor (HP:0002080)3.18834520
32Scanning speech (HP:0002168)3.17374489
33Broad metatarsal (HP:0001783)3.16041510
34Epileptic encephalopathy (HP:0200134)3.13320505
35Follicular hyperkeratosis (HP:0007502)3.13070608
36Action tremor (HP:0002345)3.08610559
37Abnormality of dentin (HP:0010299)3.01952774
38Soft skin (HP:0000977)2.97855959
39Arterial tortuosity (HP:0005116)2.95191732
40Genu recurvatum (HP:0002816)2.83583245
41Retinal dysplasia (HP:0007973)2.81497817
42Progressive cerebellar ataxia (HP:0002073)2.81108684
43Parakeratosis (HP:0001036)2.79559058
44Neonatal short-limb short stature (HP:0008921)2.76155788
45Urinary urgency (HP:0000012)2.73018138
46Coronal craniosynostosis (HP:0004440)2.72657669
47Bowel diverticulosis (HP:0005222)2.69686859
48Hyperventilation (HP:0002883)2.67770665
49Wormian bones (HP:0002645)2.67453171
50Alacrima (HP:0000522)2.66491105
51Pheochromocytoma (HP:0002666)2.64583679
52Fragile skin (HP:0001030)2.61585774
53Broad-based gait (HP:0002136)2.61541161
54Dialeptic seizures (HP:0011146)2.61068278
55Visual hallucinations (HP:0002367)2.60921183
56Absence seizures (HP:0002121)2.53851552
57Progressive inability to walk (HP:0002505)2.52168343
58Lower limb muscle weakness (HP:0007340)2.50580164
59Insomnia (HP:0100785)2.49408216
60Dysdiadochokinesis (HP:0002075)2.49106592
61Leukodystrophy (HP:0002415)2.47966602
62Slow saccadic eye movements (HP:0000514)2.47520655
63Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.46381885
64Hypoventilation (HP:0002791)2.46325587
65Akinesia (HP:0002304)2.45063704
66Mitral regurgitation (HP:0001653)2.43460908
67Truncal ataxia (HP:0002078)2.39886774
68Generalized tonic-clonic seizures (HP:0002069)2.39294885
69Cervical subluxation (HP:0003308)2.36569983
70Slender build (HP:0001533)2.36364759
71Overgrowth (HP:0001548)2.36254048
72Abnormal auditory evoked potentials (HP:0006958)2.36163506
73Neuroendocrine neoplasm (HP:0100634)2.33602864
74Increased variability in muscle fiber diameter (HP:0003557)2.33172976
75Hyperextensible skin (HP:0000974)2.32992284
76Thickened helices (HP:0000391)2.31646939
77Vertebral compression fractures (HP:0002953)2.30263112
78Clumsiness (HP:0002312)2.29678663
79Gaze-evoked nystagmus (HP:0000640)2.28376562
80Limb dystonia (HP:0002451)2.26367741
81Urinary bladder sphincter dysfunction (HP:0002839)2.26243834
82Anxiety (HP:0000739)2.25627154
83Renal duplication (HP:0000075)2.25240788
84CNS hypomyelination (HP:0003429)2.24668179
85Obstructive sleep apnea (HP:0002870)2.24438431
86Cerebral hemorrhage (HP:0001342)2.23020105
87Foot dorsiflexor weakness (HP:0009027)2.19541591
88Turricephaly (HP:0000262)2.17838039
89Impaired vibration sensation in the lower limbs (HP:0002166)2.17700237
90Generalized myoclonic seizures (HP:0002123)2.17535713
91Upper limb amyotrophy (HP:0009129)2.16693011
92Distal upper limb amyotrophy (HP:0007149)2.16693011
93Mildly elevated creatine phosphokinase (HP:0008180)2.15469457
94Delusions (HP:0000746)2.11452792
95Neuronal loss in central nervous system (HP:0002529)2.09481408
96Wide anterior fontanel (HP:0000260)2.09235880
97Mild short stature (HP:0003502)2.07450939
98Hammertoe (HP:0001765)2.07297422
99Morphological abnormality of the pyramidal tract (HP:0002062)2.07229706
100Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.07144942
101Postural instability (HP:0002172)2.06925398
102Ulnar bowing (HP:0003031)2.06785647
103Clonus (HP:0002169)2.06609766
104Aplasia involving bones of the extremities (HP:0009825)2.05257544
105Aplasia involving bones of the upper limbs (HP:0009823)2.05257544
106Aplasia of the phalanges of the hand (HP:0009802)2.05257544
107Absent speech (HP:0001344)2.04548756
108Segmental peripheral demyelination/remyelination (HP:0003481)2.03854154
109Abnormality of the foot musculature (HP:0001436)2.02797089
110Mitral valve prolapse (HP:0001634)2.01655547
111Megalencephaly (HP:0001355)1.99758561
112Mutism (HP:0002300)1.99415654
113Febrile seizures (HP:0002373)1.98867745
114Blue sclerae (HP:0000592)1.98547123
115Increased circulating renin level (HP:0000848)1.97839401
116Bowel incontinence (HP:0002607)1.97714196
117Aortic regurgitation (HP:0001659)1.97488746
118Bundle branch block (HP:0011710)1.96675295
119Depression (HP:0000716)1.95593619
120Decreased lacrimation (HP:0000633)1.94161526
121Focal dystonia (HP:0004373)1.94142337
122Craniofacial dystonia (HP:0012179)1.92816221
123Increased serum pyruvate (HP:0003542)1.92494465
124Abnormality of glycolysis (HP:0004366)1.92494465
125Diplopia (HP:0000651)1.90480751
126Abnormality of binocular vision (HP:0011514)1.90480751
127Hand muscle atrophy (HP:0009130)1.89339292
128Overriding aorta (HP:0002623)1.89073677
129Excessive salivation (HP:0003781)1.88769471
130Drooling (HP:0002307)1.88769471
131Hemiparesis (HP:0001269)1.88387770
132Spastic tetraparesis (HP:0001285)1.88382389
133Hyperacusis (HP:0010780)1.87776883
134Poor speech (HP:0002465)1.87620543
135Abnormal eating behavior (HP:0100738)1.87394179
136Metabolic alkalosis (HP:0200114)1.87237553
137Achilles tendon contracture (HP:0001771)1.86887795
138Torticollis (HP:0000473)1.86843989
139Type II lissencephaly (HP:0007260)1.86677047
140Decreased motor nerve conduction velocity (HP:0003431)1.86027461
141Poor eye contact (HP:0000817)1.85978011
142Flat cornea (HP:0007720)1.85835944
143Deviation of the hallux (HP:0010051)1.84281816
144Partial duplication of the phalanx of hand (HP:0009999)1.83754518
145Congenital glaucoma (HP:0001087)1.83388775
146Split foot (HP:0001839)1.81757241
147Anteriorly placed anus (HP:0001545)1.81518918
148Infantile muscular hypotonia (HP:0008947)1.81382103
149Abnormality of saccadic eye movements (HP:0000570)1.81343407
150Delayed gross motor development (HP:0002194)1.81258380
151Humeroradial synostosis (HP:0003041)1.79588174
152Synostosis involving the elbow (HP:0003938)1.79588174
153Abnormal large intestine physiology (HP:0012700)1.79339495
154Autoamputation (HP:0001218)1.79244368
155Elbow flexion contracture (HP:0002987)1.79058200
156Biconcave vertebral bodies (HP:0004586)1.77640697
157Hallux valgus (HP:0001822)1.77119343
158Spastic paraparesis (HP:0002313)1.76893909
159Mitral stenosis (HP:0001718)1.76750950
160Stridor (HP:0010307)1.76643738
161Abnormality of skeletal muscle fiber size (HP:0012084)1.75023672
162Hyporeflexia of lower limbs (HP:0002600)1.69653960
163Elfin facies (HP:0004428)1.68599948
164Joint laxity (HP:0001388)1.68579824
165Buphthalmos (HP:0000557)1.68319418
166Generalized amyotrophy (HP:0003700)1.67570320
167Aortic valve stenosis (HP:0001650)1.66477768
168Dilatation of the ascending aorta (HP:0005111)1.65801906
169Spinal cord compression (HP:0002176)1.64396928
170Protruding ear (HP:0000411)1.64081043
171Limb-girdle muscle weakness (HP:0003325)1.63801570
172Bradycardia (HP:0001662)1.61429045
173Limited hip movement (HP:0008800)1.61021502
174Cerebral aneurysm (HP:0004944)1.60692926
175Partial duplication of thumb phalanx (HP:0009944)1.60639863
176Hypoplasia of the iris (HP:0007676)1.60271774
177Round ear (HP:0100830)1.58429260

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.56950889
2OXSR13.31975133
3MYLK2.93152279
4EPHA42.82662496
5LATS22.68798360
6CASK2.63528552
7NTRK32.49272190
8MARK12.21743191
9PKN12.18554077
10PNCK2.15988730
11EPHB22.09404591
12NTRK12.08758595
13CDK192.02915798
14PDGFRA2.01548791
15BCR2.01161709
16MAPKAPK51.89798053
17STK381.88535769
18MAP3K41.86389125
19UHMK11.86350917
20WNK41.85197747
21MAP3K91.82339298
22DDR21.82322890
23PAK61.81576508
24EPHB11.79562808
25TNIK1.75438535
26PTK21.73614595
27CAMK2B1.59286680
28WNK11.56461064
29MOS1.56084751
30LIMK11.53950360
31MINK11.52155901
32PRPF4B1.49376655
33TESK11.48435823
34MAP2K71.46657397
35KSR21.46462712
36SGK2231.46301157
37SGK4941.46301157
38PAK21.42830859
39ROCK21.35616987
40FGR1.34139828
41RIPK11.34064833
42LMTK21.33574614
43CDK51.31193363
44FGFR21.30051569
45ABL21.25941530
46NEK61.25473372
47NTRK21.24301625
48TTN1.20493068
49CAMK2D1.20122023
50ILK1.19053508
51DAPK21.18969244
52ARAF1.17384309
53PHKG21.17071728
54PHKG11.17071728
55BRAF1.16549983
56CAMK2A1.15383940
57MET1.11604354
58CSNK1G21.10720465
59CSNK1G31.10228633
60PRKD31.07688733
61MAPK131.04787338
62GRK51.03864637
63MARK21.03234525
64CDK141.03203477
65PLK21.03144683
66CSNK1A1L1.01364793
67CLK11.00789060
68CAMK2G0.99186754
69MAP3K130.98164787
70CDK150.96947511
71CDK180.96633029
72SIK10.95784409
73PAK30.94942704
74ROCK10.93855497
75PRKD20.93675707
76CAMKK10.93313518
77TYRO30.93243654
78FES0.91154237
79LATS10.90758134
80MAP2K40.86534977
81CDK11A0.86361568
82TESK20.86287320
83TRIB30.85041146
84RIPK40.82769974
85PTK2B0.82430942
86AKT30.79964168
87DYRK20.79497916
88PRKCE0.79035057
89CSNK1G10.76277308
90MAP3K20.76020618
91PRKCG0.70137656
92KSR10.67620607
93ICK0.66569906
94PINK10.66459572
95PRKCQ0.64949572
96BMPR20.64827876
97MUSK0.64412329
98PDPK10.64202933
99DAPK30.62872951
100PDGFRB0.62464929
101PRKCH0.62414474
102MAP3K120.61700164
103ADRBK10.60634926
104BRSK10.60373291
105PRKG20.58653627
106STK110.58506409
107FYN0.58070349
108PAK10.58039438
109PRKD10.57760573
110PBK0.55820362
111DYRK1A0.52345292
112NEK90.52106934
113RPS6KA20.52091031
114PIM20.52008282
115STK38L0.51739190
116PRKG10.51096048
117DMPK0.51011826
118ERBB40.49402282
119CAMK10.49335650
120GRK70.48387825
121CAMK1G0.46819482
122DAPK10.46586591
123PAK40.45779771
124RET0.44209099
125EPHA20.44128231
126CSNK1A10.43262017
127SGK10.42421112
128MAPK120.42403071
129PDK10.41969465
130MTOR0.41388866
131MAP2K10.41034785
132SIK20.40431367
133MAPK100.38782464
134PRKCZ0.38438656
135IRAK20.38406033
136GRK10.37785301
137ADRBK20.36767877
138PRKACA0.36658595
139PRKACB0.36303653
140NME10.35944853
141CDC42BPA0.34256888
142CDK80.32981389
143SGK30.32759357

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.15075796
2Nicotine addiction_Homo sapiens_hsa050332.83936516
3GABAergic synapse_Homo sapiens_hsa047272.41484469
4Synaptic vesicle cycle_Homo sapiens_hsa047212.41457521
5Glutamatergic synapse_Homo sapiens_hsa047242.34656753
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30982949
7Fatty acid elongation_Homo sapiens_hsa000622.26373701
8Steroid biosynthesis_Homo sapiens_hsa001002.19972749
9ECM-receptor interaction_Homo sapiens_hsa045122.18838334
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12175072
11Morphine addiction_Homo sapiens_hsa050322.11054560
12Circadian entrainment_Homo sapiens_hsa047132.05277257
13Serotonergic synapse_Homo sapiens_hsa047261.84385452
14Long-term potentiation_Homo sapiens_hsa047201.83694133
15Amphetamine addiction_Homo sapiens_hsa050311.80222847
16Olfactory transduction_Homo sapiens_hsa047401.78016920
17Ether lipid metabolism_Homo sapiens_hsa005651.76212062
18Long-term depression_Homo sapiens_hsa047301.76135259
19Salivary secretion_Homo sapiens_hsa049701.75411625
20Axon guidance_Homo sapiens_hsa043601.75022507
21Dopaminergic synapse_Homo sapiens_hsa047281.67960686
22Collecting duct acid secretion_Homo sapiens_hsa049661.64725321
23Oxidative phosphorylation_Homo sapiens_hsa001901.61416171
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.60742639
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.59702579
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.58275877
27Focal adhesion_Homo sapiens_hsa045101.56813713
28Cocaine addiction_Homo sapiens_hsa050301.51043876
29Gastric acid secretion_Homo sapiens_hsa049711.50522719
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47942114
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45128359
32Taste transduction_Homo sapiens_hsa047421.43562746
33Renin secretion_Homo sapiens_hsa049241.40699337
34Cholinergic synapse_Homo sapiens_hsa047251.40404320
35Hippo signaling pathway_Homo sapiens_hsa043901.40165280
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37658095
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33376905
38Nitrogen metabolism_Homo sapiens_hsa009101.32757320
39Alzheimers disease_Homo sapiens_hsa050101.31622387
40Cardiac muscle contraction_Homo sapiens_hsa042601.29608532
41Insulin secretion_Homo sapiens_hsa049111.23669074
42Vibrio cholerae infection_Homo sapiens_hsa051101.23177361
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19755426
44Parkinsons disease_Homo sapiens_hsa050121.18728912
45Phototransduction_Homo sapiens_hsa047441.17869945
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17598796
47Calcium signaling pathway_Homo sapiens_hsa040201.14493662
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14418401
49Basal cell carcinoma_Homo sapiens_hsa052171.13586283
50Oxytocin signaling pathway_Homo sapiens_hsa049211.12551674
51Gap junction_Homo sapiens_hsa045401.12371780
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10908205
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08544980
54Vascular smooth muscle contraction_Homo sapiens_hsa042701.08064020
55Protein digestion and absorption_Homo sapiens_hsa049741.07272473
56Vitamin B6 metabolism_Homo sapiens_hsa007501.02871954
57Arginine and proline metabolism_Homo sapiens_hsa003301.01402731
58Proteoglycans in cancer_Homo sapiens_hsa052050.96262708
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95726830
60cAMP signaling pathway_Homo sapiens_hsa040240.94222456
61Melanoma_Homo sapiens_hsa052180.93077019
62GnRH signaling pathway_Homo sapiens_hsa049120.91896139
63Sphingolipid metabolism_Homo sapiens_hsa006000.88514222
64ErbB signaling pathway_Homo sapiens_hsa040120.87652569
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87443586
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87428470
67Butanoate metabolism_Homo sapiens_hsa006500.87192345
68Pancreatic secretion_Homo sapiens_hsa049720.85300333
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.85240118
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84783519
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.83037788
72Dorso-ventral axis formation_Homo sapiens_hsa043200.82756457
73Renal cell carcinoma_Homo sapiens_hsa052110.82116041
74Circadian rhythm_Homo sapiens_hsa047100.82044231
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81573883
76Melanogenesis_Homo sapiens_hsa049160.79815521
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79311979
78Linoleic acid metabolism_Homo sapiens_hsa005910.78442802
79Adherens junction_Homo sapiens_hsa045200.77831237
80Sulfur metabolism_Homo sapiens_hsa009200.76241271
81Sulfur relay system_Homo sapiens_hsa041220.75468281
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75293363
83Ras signaling pathway_Homo sapiens_hsa040140.75046832
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71773326
85Endocytosis_Homo sapiens_hsa041440.70622788
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69731948
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67380450
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67173564
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66656458
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64955412
91Estrogen signaling pathway_Homo sapiens_hsa049150.64785716
92TGF-beta signaling pathway_Homo sapiens_hsa043500.63082439
93beta-Alanine metabolism_Homo sapiens_hsa004100.61927851
94Choline metabolism in cancer_Homo sapiens_hsa052310.61202655
95Huntingtons disease_Homo sapiens_hsa050160.61037527
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60756141
97Glucagon signaling pathway_Homo sapiens_hsa049220.59028786
98Tight junction_Homo sapiens_hsa045300.58592684
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.57914481
100Amoebiasis_Homo sapiens_hsa051460.57658050
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57451641
102Rheumatoid arthritis_Homo sapiens_hsa053230.57243102
103MAPK signaling pathway_Homo sapiens_hsa040100.56419108
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.56108340
105Prion diseases_Homo sapiens_hsa050200.55841298
106Folate biosynthesis_Homo sapiens_hsa007900.54674653
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54377600
108AMPK signaling pathway_Homo sapiens_hsa041520.54245549
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53897943
110Dilated cardiomyopathy_Homo sapiens_hsa054140.53859211
111Thyroid hormone synthesis_Homo sapiens_hsa049180.52312681
112Ovarian steroidogenesis_Homo sapiens_hsa049130.51632997
113Bile secretion_Homo sapiens_hsa049760.46844621
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.46498413
115Phagosome_Homo sapiens_hsa041450.46217900
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46065730
117Pathways in cancer_Homo sapiens_hsa052000.45842130
118Bladder cancer_Homo sapiens_hsa052190.45146382
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45062295
120Histidine metabolism_Homo sapiens_hsa003400.44853723
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44658583
122Oocyte meiosis_Homo sapiens_hsa041140.44133660
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43373050
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43192213
125Alcoholism_Homo sapiens_hsa050340.42993066
126Mineral absorption_Homo sapiens_hsa049780.42817819
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42492342
128Type II diabetes mellitus_Homo sapiens_hsa049300.42402556
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41393925
130Glioma_Homo sapiens_hsa052140.40573572
131Rap1 signaling pathway_Homo sapiens_hsa040150.38013985
132Wnt signaling pathway_Homo sapiens_hsa043100.37480867
133Hedgehog signaling pathway_Homo sapiens_hsa043400.37440221
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35145031
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34794503

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