LARS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.74749749
2folic acid-containing compound biosynthetic process (GO:0009396)5.67108960
3nuclear pore complex assembly (GO:0051292)5.56645544
4DNA unwinding involved in DNA replication (GO:0006268)5.00274258
5IMP biosynthetic process (GO:0006188)4.79002229
6protein localization to kinetochore (GO:0034501)4.62008260
7mitotic nuclear envelope disassembly (GO:0007077)4.45375666
8regulation of posttranscriptional gene silencing (GO:0060147)4.28898994
9regulation of gene silencing by miRNA (GO:0060964)4.28898994
10regulation of gene silencing by RNA (GO:0060966)4.28898994
11membrane disassembly (GO:0030397)4.21020666
12nuclear envelope disassembly (GO:0051081)4.21020666
13IMP metabolic process (GO:0046040)4.19630405
14pore complex assembly (GO:0046931)4.17938115
15formation of translation preinitiation complex (GO:0001731)4.06960017
16nucleobase biosynthetic process (GO:0046112)4.06024323
17* regulation of translational fidelity (GO:0006450)3.98912812
18DNA replication-dependent nucleosome assembly (GO:0006335)3.96923702
19DNA replication-dependent nucleosome organization (GO:0034723)3.96923702
20DNA duplex unwinding (GO:0032508)3.86026173
21DNA geometric change (GO:0032392)3.85090349
22double-strand break repair via nonhomologous end joining (GO:0006303)3.84976451
23non-recombinational repair (GO:0000726)3.84976451
24DNA replication initiation (GO:0006270)3.79380720
25ribosome assembly (GO:0042255)3.78865509
26regulation of translational termination (GO:0006449)3.74101527
27DNA topological change (GO:0006265)3.70156285
28L-serine metabolic process (GO:0006563)3.69582144
29mitotic metaphase plate congression (GO:0007080)3.68431798
30DNA strand elongation involved in DNA replication (GO:0006271)3.60565629
31protein localization to chromosome, centromeric region (GO:0071459)3.60417235
32heterochromatin organization (GO:0070828)3.56851046
33pre-miRNA processing (GO:0031054)3.52736681
34sister chromatid segregation (GO:0000819)3.51130002
35purine nucleobase biosynthetic process (GO:0009113)3.50561143
36regulation of spindle organization (GO:0090224)3.49098470
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.46686104
38regulation of histone H3-K9 methylation (GO:0051570)3.46434131
39regulation of helicase activity (GO:0051095)3.44874807
40mitotic chromosome condensation (GO:0007076)3.44512169
41paraxial mesoderm development (GO:0048339)3.44359452
42negative regulation of mitotic sister chromatid separation (GO:2000816)3.41249595
43negative regulation of sister chromatid segregation (GO:0033046)3.41249595
44negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.41249595
45negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.41249595
46negative regulation of mitotic sister chromatid segregation (GO:0033048)3.41249595
47DNA strand elongation (GO:0022616)3.40379478
48tetrahydrofolate metabolic process (GO:0046653)3.39419009
49regulation of mitotic spindle organization (GO:0060236)3.38819331
50spliceosomal tri-snRNP complex assembly (GO:0000244)3.38614120
51maturation of SSU-rRNA (GO:0030490)3.38021126
52mitotic sister chromatid segregation (GO:0000070)3.35758638
53mitotic sister chromatid cohesion (GO:0007064)3.35692793
54negative regulation of histone methylation (GO:0031061)3.35502651
55DNA ligation (GO:0006266)3.33927520
56chaperone-mediated protein complex assembly (GO:0051131)3.31281018
57establishment of viral latency (GO:0019043)3.31114576
58histone exchange (GO:0043486)3.30951329
59* tRNA aminoacylation for protein translation (GO:0006418)3.30170225
60COPI coating of Golgi vesicle (GO:0048205)3.27820465
61Golgi transport vesicle coating (GO:0048200)3.27820465
62regulation of mitotic metaphase/anaphase transition (GO:0030071)3.26460049
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.26460049
64nuclear envelope organization (GO:0006998)3.25396749
65positive regulation of SMAD protein import into nucleus (GO:0060391)3.24866578
66somatic diversification of immune receptors via somatic mutation (GO:0002566)3.24128893
67somatic hypermutation of immunoglobulin genes (GO:0016446)3.24128893
68positive regulation of chromosome segregation (GO:0051984)3.23857398
69metaphase plate congression (GO:0051310)3.23423722
70mitotic spindle assembly checkpoint (GO:0007094)3.22060907
71regulation of sister chromatid segregation (GO:0033045)3.21618772
72regulation of mitotic sister chromatid separation (GO:0010965)3.21618772
73regulation of mitotic sister chromatid segregation (GO:0033047)3.21618772
74dosage compensation (GO:0007549)3.20267999
75chromatin assembly (GO:0031497)3.18359264
76regulation of DNA endoreduplication (GO:0032875)3.15047039
77* tRNA aminoacylation (GO:0043039)3.14021451
78* amino acid activation (GO:0043038)3.14021451
79histone H2A monoubiquitination (GO:0035518)3.12375482
80nucleotide-excision repair, DNA gap filling (GO:0006297)3.09659858
81ribosome biogenesis (GO:0042254)3.07755933
82telomere maintenance via telomerase (GO:0007004)3.06732633
83telomere maintenance via semi-conservative replication (GO:0032201)3.04800926
84regulation of centrosome cycle (GO:0046605)3.04613772
85protein complex localization (GO:0031503)3.04598451
86pteridine-containing compound biosynthetic process (GO:0042559)3.04392560
87regulation of centriole replication (GO:0046599)3.00512663
88regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.00005900
89regulation of mitotic spindle checkpoint (GO:1903504)3.00005900
90DNA double-strand break processing (GO:0000729)2.97191042
91chromatin remodeling at centromere (GO:0031055)2.95678328
92negative regulation of DNA-dependent DNA replication (GO:2000104)2.95483983
93mitotic recombination (GO:0006312)2.95256722
94establishment of chromosome localization (GO:0051303)2.94689798
95ATP-dependent chromatin remodeling (GO:0043044)2.92702909
96regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.92380490
97positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.91461687
98positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.91461687
99positive regulation of mitotic sister chromatid separation (GO:1901970)2.91461687
100RNA-dependent DNA replication (GO:0006278)2.89975235
101DNA conformation change (GO:0071103)2.88920316
102peptidyl-arginine omega-N-methylation (GO:0035247)2.88568382
103negative regulation of DNA repair (GO:0045738)2.87785356
104replication fork processing (GO:0031297)2.87532072
105ribosomal large subunit biogenesis (GO:0042273)2.87001663
106telomere maintenance (GO:0000723)2.85367363
107regulation of RNA export from nucleus (GO:0046831)2.85248252
108glutamine metabolic process (GO:0006541)2.84711153
109mRNA transport (GO:0051028)2.83613852
110kinetochore organization (GO:0051383)2.83004372
111protein K6-linked ubiquitination (GO:0085020)2.82570404
112regulation of telomere maintenance via telomerase (GO:0032210)2.82521514
113maturation of 5.8S rRNA (GO:0000460)2.82299706
114regulation of sister chromatid cohesion (GO:0007063)2.82019556
115telomere organization (GO:0032200)2.81672424
116regulation of SMAD protein import into nucleus (GO:0060390)2.81140244
117telomere maintenance via recombination (GO:0000722)2.80797960
118regulation of chromosome segregation (GO:0051983)2.80527247
119attachment of spindle microtubules to kinetochore (GO:0008608)2.79384074
120CENP-A containing nucleosome assembly (GO:0034080)2.79235492
121regulation of gene silencing (GO:0060968)2.78785224
122chromatin assembly or disassembly (GO:0006333)2.75999160
123spindle checkpoint (GO:0031577)2.75448286
124mitotic spindle checkpoint (GO:0071174)2.75125855
125telomere maintenance via telomere lengthening (GO:0010833)2.74285558
126negative regulation of chromosome segregation (GO:0051985)2.73331380
127ribonucleoprotein complex biogenesis (GO:0022613)2.73043168
128DNA replication-independent nucleosome organization (GO:0034724)2.72736368
129DNA replication-independent nucleosome assembly (GO:0006336)2.72736368
130spindle assembly checkpoint (GO:0071173)2.70132654
131establishment of integrated proviral latency (GO:0075713)2.70085266
132DNA replication checkpoint (GO:0000076)2.69338914
133folic acid-containing compound metabolic process (GO:0006760)2.68331431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.88285849
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.21458917
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.20419793
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.50339472
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.18788610
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.06711986
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.05815930
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.03434163
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84348692
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75162608
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.69575255
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.52603837
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37867790
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.31200733
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29900367
16AR_21909140_ChIP-Seq_LNCAP_Human2.18517056
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16731936
18* ETS1_20019798_ChIP-Seq_JURKAT_Human2.07914394
19XRN2_22483619_ChIP-Seq_HELA_Human2.07031441
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06401193
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.04241489
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03789639
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.02856081
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01655667
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00590423
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99937498
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.94894702
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.92637050
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91400790
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.86805494
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86073959
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81862334
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81273074
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79182563
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77688041
36VDR_23849224_ChIP-Seq_CD4+_Human1.70787340
37MYC_22102868_ChIP-Seq_BL_Human1.69216179
38* ELK1_19687146_ChIP-ChIP_HELA_Human1.68094782
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68050029
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67621747
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65758966
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.63502571
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.63502571
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.63502571
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.62883941
46DCP1A_22483619_ChIP-Seq_HELA_Human1.61391614
47FOXP3_21729870_ChIP-Seq_TREG_Human1.57764138
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55877776
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55131570
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52842390
51TFEB_21752829_ChIP-Seq_HELA_Human1.51169667
52TTF2_22483619_ChIP-Seq_HELA_Human1.50728032
53KDM5A_27292631_Chip-Seq_BREAST_Human1.48774360
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47840218
55GABP_19822575_ChIP-Seq_HepG2_Human1.47140781
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40705778
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39167466
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37210502
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36427541
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35625774
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35161529
62CIITA_25753668_ChIP-Seq_RAJI_Human1.34960915
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34193656
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33091566
65* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32880731
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32562077
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30925298
68SOX2_16153702_ChIP-ChIP_HESCs_Human1.30587343
69* NANOG_16153702_ChIP-ChIP_HESCs_Human1.30572711
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30452360
71FUS_26573619_Chip-Seq_HEK293_Human1.30139733
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29866182
73EWS_26573619_Chip-Seq_HEK293_Human1.29123980
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21948610
75MYC_18940864_ChIP-ChIP_HL60_Human1.21647913
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20126293
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19779554
78NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14974767
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14643628
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14624746
81* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14305204
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14189982
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.13924597
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.12905442
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11845691
86TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11331432
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10879365
88* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10366636
89SOX17_20123909_ChIP-Seq_XEN_Mouse1.10191158
90SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07901107
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07323837
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06697660
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05628774
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.04006020
95* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04004529
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03445543
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02965613
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01226395
99CHD1_26751641_Chip-Seq_LNCaP_Human0.99532895
100CLOCK_20551151_ChIP-Seq_293T_Human0.98891138
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97304606
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96945948
103YY1_21170310_ChIP-Seq_MESCs_Mouse0.96848000
104* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96185754
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95721239
106HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95186255
107ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92153769
108EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92061513
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91232766
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90925767
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90404975
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90281859
113ATF3_27146783_Chip-Seq_COLON_Human0.88853208
114ZNF263_19887448_ChIP-Seq_K562_Human0.87484082
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85102059
116WT1_19549856_ChIP-ChIP_CCG9911_Human0.78913237
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77960113
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.77540248
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.74326508
120POU3F2_20337985_ChIP-ChIP_501MEL_Human0.66711516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.88587106
2MP0004957_abnormal_blastocyst_morpholog3.77257942
3MP0010094_abnormal_chromosome_stability3.50723761
4MP0010352_gastrointestinal_tract_polyps3.48486495
5MP0003111_abnormal_nucleus_morphology3.43788682
6MP0003077_abnormal_cell_cycle3.27143048
7MP0008057_abnormal_DNA_replication3.06653062
8MP0003705_abnormal_hypodermis_morpholog2.78366544
9MP0001730_embryonic_growth_arrest2.60513157
10MP0010307_abnormal_tumor_latency2.43987164
11MP0008007_abnormal_cellular_replicative2.37670455
12MP0000350_abnormal_cell_proliferation2.31395499
13MP0003123_paternal_imprinting2.23789993
14MP0008058_abnormal_DNA_repair2.21669317
15MP0005076_abnormal_cell_differentiation2.21198144
16MP0009697_abnormal_copulation2.13131897
17MP0008438_abnormal_cutaneous_collagen2.12409036
18MP0002877_abnormal_melanocyte_morpholog2.07162200
19MP0004197_abnormal_fetal_growth/weight/2.05828562
20MP0008932_abnormal_embryonic_tissue2.04889616
21MP0002084_abnormal_developmental_patter1.96415683
22MP0001672_abnormal_embryogenesis/_devel1.95295623
23MP0005380_embryogenesis_phenotype1.95295623
24MP0000537_abnormal_urethra_morphology1.90977686
25MP0001697_abnormal_embryo_size1.90383043
26MP0003890_abnormal_embryonic-extraembry1.88569001
27MP0003566_abnormal_cell_adhesion1.87110970
28MP0003984_embryonic_growth_retardation1.79439163
29MP0002085_abnormal_embryonic_tissue1.78908764
30MP0002088_abnormal_embryonic_growth/wei1.77787294
31MP0002086_abnormal_extraembryonic_tissu1.71689775
32MP0002080_prenatal_lethality1.69036652
33MP0003806_abnormal_nucleotide_metabolis1.60412782
34MP0010030_abnormal_orbit_morphology1.55066159
35MP0010234_abnormal_vibrissa_follicle1.49926863
36MP0003567_abnormal_fetal_cardiomyocyte1.49595006
37MP0003283_abnormal_digestive_organ1.47745040
38MP0001661_extended_life_span1.45433919
39MP0006054_spinal_hemorrhage1.44964375
40MP0003119_abnormal_digestive_system1.43708881
41MP0006292_abnormal_olfactory_placode1.42671959
42MP0001293_anophthalmia1.40515676
43MP0002009_preneoplasia1.39346847
44MP0003121_genomic_imprinting1.36470803
45MP0005023_abnormal_wound_healing1.30831488
46MP0000733_abnormal_muscle_development1.26767851
47MP0004133_heterotaxia1.26405272
48MP0009053_abnormal_anal_canal1.25284197
49MP0006035_abnormal_mitochondrial_morpho1.20825225
50MP0002396_abnormal_hematopoietic_system1.18363369
51MP0003937_abnormal_limbs/digits/tail_de1.17060383
52MP0002653_abnormal_ependyma_morphology1.15740088
53MP0003786_premature_aging1.15637853
54MP0002111_abnormal_tail_morphology1.15011234
55MP0001849_ear_inflammation1.13640936
56MP0000313_abnormal_cell_death1.13592325
57MP0002697_abnormal_eye_size1.13462202
58MP0009672_abnormal_birth_weight1.11431134
59MP0009703_decreased_birth_body1.06727777
60MP0002233_abnormal_nose_morphology1.06190817
61MP0000490_abnormal_crypts_of1.06068978
62MP0001188_hyperpigmentation1.05556040
63MP0000428_abnormal_craniofacial_morphol1.03924704
64MP0001915_intracranial_hemorrhage1.03897321
65MP0002938_white_spotting1.03584793
66MP0005623_abnormal_meninges_morphology1.01819015
67MP0004808_abnormal_hematopoietic_stem1.01358589
68MP0005275_abnormal_skin_tensile0.99645459
69MP0002019_abnormal_tumor_incidence0.98541382
70MP0003941_abnormal_skin_development0.97758716
71MP0006072_abnormal_retinal_apoptosis0.97498679
72MP0003646_muscle_fatigue0.97449708
73MP0004233_abnormal_muscle_weight0.96170902
74MP0002092_abnormal_eye_morphology0.94556619
75MP0004084_abnormal_cardiac_muscle0.93799005
76MP0003385_abnormal_body_wall0.93608470
77MP0000579_abnormal_nail_morphology0.92086321
78MP0004264_abnormal_extraembryonic_tissu0.90946896
79MP0005384_cellular_phenotype0.87399698
80MP0005621_abnormal_cell_physiology0.86937832
81MP0005187_abnormal_penis_morphology0.86535611
82MP0000049_abnormal_middle_ear0.86456717
83MP0003861_abnormal_nervous_system0.86332163
84MP0000569_abnormal_digit_pigmentation0.85470691
85MP0003315_abnormal_perineum_morphology0.85320247
86MP0002925_abnormal_cardiovascular_devel0.84886620
87MP0002210_abnormal_sex_determination0.84589681
88MP0000358_abnormal_cell_content/0.84308700
89MP0001929_abnormal_gametogenesis0.84288602
90MP0000432_abnormal_head_morphology0.83624377
91MP0000647_abnormal_sebaceous_gland0.82653238
92MP0008789_abnormal_olfactory_epithelium0.80732043
93MP0001286_abnormal_eye_development0.80687393
94MP0000516_abnormal_urinary_system0.80350522
95MP0005367_renal/urinary_system_phenotyp0.80350522
96MP0008877_abnormal_DNA_methylation0.79753217
97MP0004185_abnormal_adipocyte_glucose0.79572138
98MP0002269_muscular_atrophy0.79150485
99MP0005220_abnormal_exocrine_pancreas0.78888376
100MP0002254_reproductive_system_inflammat0.78277063
101MP0003935_abnormal_craniofacial_develop0.77767020
102MP0000371_diluted_coat_color0.76864421
103MP0003115_abnormal_respiratory_system0.75475530
104MP0005503_abnormal_tendon_morphology0.75162525
105MP0002102_abnormal_ear_morphology0.73854998
106MP0001177_atelectasis0.72153694
107MP0000762_abnormal_tongue_morphology0.71076896
108MP0003300_gastrointestinal_ulcer0.70542498
109MP0003942_abnormal_urinary_system0.70449445
110MP0003718_maternal_effect0.69359200
111MP0000653_abnormal_sex_gland0.69181388
112MP0002160_abnormal_reproductive_system0.68820374
113MP0000750_abnormal_muscle_regeneration0.67123682
114MP0003091_abnormal_cell_migration0.66619678
115MP0000266_abnormal_heart_morphology0.66125729
116MP0003221_abnormal_cardiomyocyte_apopto0.65446741
117MP0008770_decreased_survivor_rate0.64279879
118MP0010678_abnormal_skin_adnexa0.63890740
119MP0008775_abnormal_heart_ventricle0.63604003
120MP0002081_perinatal_lethality0.63584522
121MP0001346_abnormal_lacrimal_gland0.63385442
122MP0001243_abnormal_dermal_layer0.63293883
123MP0000858_altered_metastatic_potential0.61560955
124MP0008995_early_reproductive_senescence0.60966826
125MP0000377_abnormal_hair_follicle0.60460114
126MP0004272_abnormal_basement_membrane0.60278958
127MP0010630_abnormal_cardiac_muscle0.60260705
128MP0002114_abnormal_axial_skeleton0.60248328
129MP0001299_abnormal_eye_distance/0.59074214
130MP0001529_abnormal_vocalization0.59018234
131MP0002234_abnormal_pharynx_morphology0.58955809
132MP0003755_abnormal_palate_morphology0.58800147
133MP0001145_abnormal_male_reproductive0.58734339
134MP0000477_abnormal_intestine_morphology0.58680716
135MP0005508_abnormal_skeleton_morphology0.58447351

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.28480878
2Abnormality of the astrocytes (HP:0100707)3.49937613
3Astrocytoma (HP:0009592)3.49937613
4Selective tooth agenesis (HP:0001592)3.36786891
5Colon cancer (HP:0003003)3.33523002
6Abnormality of the anterior horn cell (HP:0006802)3.23505076
7Degeneration of anterior horn cells (HP:0002398)3.23505076
8Medulloblastoma (HP:0002885)3.18940160
9Meckel diverticulum (HP:0002245)3.07752268
10Deviation of the thumb (HP:0009603)3.02925037
11Missing ribs (HP:0000921)3.02472058
12Nephroblastoma (Wilms tumor) (HP:0002667)2.97786647
13Abnormality of the ileum (HP:0001549)2.92317322
14Abnormality of the preputium (HP:0100587)2.89892150
15Aplasia/Hypoplasia of the uvula (HP:0010293)2.89096860
16Multiple enchondromatosis (HP:0005701)2.88004993
17Birth length less than 3rd percentile (HP:0003561)2.87355210
18Abnormality of the labia minora (HP:0012880)2.86170751
19Proximal placement of thumb (HP:0009623)2.85665900
20Biliary tract neoplasm (HP:0100574)2.85122353
21Embryonal renal neoplasm (HP:0011794)2.82019230
22Glioma (HP:0009733)2.81369231
23Agnosia (HP:0010524)2.71737798
24Abnormality of the calcaneus (HP:0008364)2.59010594
25Rhabdomyosarcoma (HP:0002859)2.58347992
26Abnormal lung lobation (HP:0002101)2.55437560
27Duodenal stenosis (HP:0100867)2.51755613
28Small intestinal stenosis (HP:0012848)2.51755613
29Aplasia/hypoplasia of the humerus (HP:0006507)2.49909020
30Protrusio acetabuli (HP:0003179)2.48595686
31Short humerus (HP:0005792)2.48335228
32Chromsome breakage (HP:0040012)2.37614492
33Neoplasm of the oral cavity (HP:0100649)2.34585030
34Abnormality of the carotid arteries (HP:0005344)2.27518280
3511 pairs of ribs (HP:0000878)2.26629136
36Spinal muscular atrophy (HP:0007269)2.25967849
37Rib fusion (HP:0000902)2.25141963
38Abnormality of the duodenum (HP:0002246)2.24419351
39Basal cell carcinoma (HP:0002671)2.23201186
40Cortical dysplasia (HP:0002539)2.22720878
41Neoplasm of the pancreas (HP:0002894)2.20190962
42Reticulocytopenia (HP:0001896)2.19304963
43Gastrointestinal carcinoma (HP:0002672)2.19147010
44Malignant gastrointestinal tract tumors (HP:0006749)2.19147010
45Ankle contracture (HP:0006466)2.18844794
46Abnormality of methionine metabolism (HP:0010901)2.18203709
47Angiofibromas (HP:0010615)2.16854645
48Adenoma sebaceum (HP:0009720)2.16854645
49Breast hypoplasia (HP:0003187)2.13887213
50Volvulus (HP:0002580)2.12387236
51Neoplasm of the adrenal cortex (HP:0100641)2.11440005
52Hand muscle atrophy (HP:0009130)2.11418555
53Abnormality of chromosome stability (HP:0003220)2.10743975
54Cervical subluxation (HP:0003308)2.08010597
55Abnormal biliary tract morphology (HP:0012440)2.07937955
56Absent radius (HP:0003974)2.07834105
57Microvesicular hepatic steatosis (HP:0001414)2.06307178
58Metaphyseal cupping (HP:0003021)2.05791274
59Homocystinuria (HP:0002156)2.04925560
60Abnormality of homocysteine metabolism (HP:0010919)2.04925560
61Ovarian neoplasm (HP:0100615)2.04348008
62Fused cervical vertebrae (HP:0002949)2.04333686
63Trismus (HP:0000211)2.04035203
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03934027
65Premature rupture of membranes (HP:0001788)2.02521719
66Increased nuchal translucency (HP:0010880)2.01044469
67Deep philtrum (HP:0002002)2.00987360
68Carpal bone hypoplasia (HP:0001498)2.00309080
69Cutaneous melanoma (HP:0012056)1.99713908
70Hypoplasia of the pons (HP:0012110)1.99427204
71Overlapping toe (HP:0001845)1.99411401
72Amaurosis fugax (HP:0100576)1.97664108
73Patellar aplasia (HP:0006443)1.97379063
74Increased density of long bones (HP:0006392)1.97094054
75Impulsivity (HP:0100710)1.96053162
76Uterine neoplasm (HP:0010784)1.95438386
77Neoplasm of striated muscle (HP:0009728)1.95078949
78Acute myeloid leukemia (HP:0004808)1.95040954
79Neoplasm of the rectum (HP:0100743)1.94648868
80Absent forearm bone (HP:0003953)1.92813296
81Aplasia involving forearm bones (HP:0009822)1.92813296
82Cafe-au-lait spot (HP:0000957)1.90221786
83Choanal atresia (HP:0000453)1.89698577
84Aplasia/Hypoplasia of the patella (HP:0006498)1.89630498
85Spastic diplegia (HP:0001264)1.89093531
86Neoplasm of the adrenal gland (HP:0100631)1.88410018
87Abnormality of cochlea (HP:0000375)1.88221510
88Neoplasm of the colon (HP:0100273)1.87722300
89Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.87602612
90Vertebral hypoplasia (HP:0008417)1.87602612
91Vertebral clefting (HP:0008428)1.87287000
92Progressive external ophthalmoplegia (HP:0000590)1.87102850
93Intestinal polyposis (HP:0200008)1.86821245
94Abnormality of glycolysis (HP:0004366)1.86621609
95Abnormal number of incisors (HP:0011064)1.86276428
96Atrophy/Degeneration involving motor neurons (HP:0007373)1.85662351
97Sandal gap (HP:0001852)1.84381999
98Triphalangeal thumb (HP:0001199)1.83363134
99Intestinal polyp (HP:0005266)1.83032263
100Slender long bone (HP:0003100)1.82690279
101Horseshoe kidney (HP:0000085)1.81568896
102Upper limb amyotrophy (HP:0009129)1.78579675
103Distal upper limb amyotrophy (HP:0007149)1.78579675
104High pitched voice (HP:0001620)1.78416410
105Aplasia/Hypoplasia of the sternum (HP:0006714)1.78388107
106Shallow orbits (HP:0000586)1.77451289
107Embryonal neoplasm (HP:0002898)1.77366778
108Freckling (HP:0001480)1.77096286
109Neoplasm of the small intestine (HP:0100833)1.76610360
110High anterior hairline (HP:0009890)1.76311086
111Myelodysplasia (HP:0002863)1.75071792
112Absent thumb (HP:0009777)1.74693901
113Facial cleft (HP:0002006)1.74127851
114Pelvic girdle muscle weakness (HP:0003749)1.73081687
115Short 4th metacarpal (HP:0010044)1.72818390
116Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72818390
117Ectopic kidney (HP:0000086)1.72654783
118Abnormality of the pons (HP:0007361)1.71990149
119Glossoptosis (HP:0000162)1.71269945
120Atresia of the external auditory canal (HP:0000413)1.70952027
121Abnormality of serum amino acid levels (HP:0003112)1.70715521
122Vertebral fusion (HP:0002948)1.70504613
123Oral leukoplakia (HP:0002745)1.69387874
124Rectal prolapse (HP:0002035)1.68965809
125Hyperglycinemia (HP:0002154)1.68897575
126Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68720551
127Increased serum pyruvate (HP:0003542)1.68300697
128Postnatal microcephaly (HP:0005484)1.67076816
129Ulnar bowing (HP:0003031)1.66693998
130Sloping forehead (HP:0000340)1.66676215
131Increased connective tissue (HP:0009025)1.65884027
132Subacute progressive viral hepatitis (HP:0006572)1.65424392
133Prominent nose (HP:0000448)1.65367080
134Bowel diverticulosis (HP:0005222)1.65290756
135Arteriovenous malformation (HP:0100026)1.64912857
136Pancreatic islet-cell hyperplasia (HP:0004510)1.64348081
137Calcaneovalgus deformity (HP:0001848)1.62549493
138Abnormality of aspartate family amino acid metabolism (HP:0010899)1.62020436
139Hepatoblastoma (HP:0002884)1.60326881
140Exercise-induced muscle cramps (HP:0003710)1.57346683
141Megaloblastic anemia (HP:0001889)1.56513646
142Obsessive-compulsive behavior (HP:0000722)1.55775090
143Neuroblastoma (HP:0003006)1.54731707
144Primitive neuroectodermal tumor (HP:0030065)1.54731707
145Neuroblastic tumors (HP:0004376)1.54731707
146Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.54731707
147Clubbing of toes (HP:0100760)1.53781833
148Breast carcinoma (HP:0003002)1.53678844
149Abnormality of sulfur amino acid metabolism (HP:0004339)1.52527427
150Skull defect (HP:0001362)1.51988492
151Abnormality of DNA repair (HP:0003254)1.49015007
152Progressive muscle weakness (HP:0003323)1.48930893
153Abnormality of cells of the erythroid lineage (HP:0012130)1.48533746
154Partial agenesis of the corpus callosum (HP:0001338)1.46273424
155Neuroectodermal neoplasm (HP:0030061)1.44165907
156Neuroepithelial neoplasm (HP:0030063)1.44165907
157Nervous tissue neoplasm (HP:0030060)1.44165907
158Gonadotropin excess (HP:0000837)1.43945889
159Esophageal atresia (HP:0002032)1.43540879

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.62190514
2PASK3.00774218
3WEE13.00763946
4EEF2K3.00492154
5CDK122.97843664
6EPHA22.77219850
7BUB12.74462843
8PBK2.68234333
9NEK12.47628619
10TSSK62.43693691
11TTK2.37181544
12PKN22.36772043
13RPS6KB22.28489528
14NEK22.24121768
15SCYL22.13987195
16TAF12.06485429
17SRPK11.98071070
18EIF2AK11.93684299
19VRK21.89107197
20TTN1.82902887
21BRSK21.67928362
22PLK31.67457741
23TGFBR11.66318448
24FLT31.58717830
25ATR1.57912371
26MAP3K81.56677089
27PLK11.54095957
28LATS11.51788491
29AURKB1.48037393
30BRD41.47151738
31STK101.46605654
32ALK1.40592711
33PAK41.39279083
34CHEK11.37660877
35NUAK11.37592934
36PDGFRA1.33956945
37CDK71.33014766
38ACVR1B1.30708727
39MKNK11.30153816
40MAP3K101.29255867
41MST41.27166837
42PNCK1.24486026
43CDK41.22892604
44EIF2AK31.19255294
45MET1.18692590
46CHEK21.10581417
47MTOR1.06646087
48NME11.06482042
49TNIK1.04275216
50CDK61.03857438
51AURKA1.03452528
52ATM1.03168979
53TESK21.02440814
54EIF2AK20.99784835
55LRRK20.97375013
56RPS6KA40.96137890
57TRIB30.96114285
58SMG10.93135769
59MELK0.91585806
60STK30.90426321
61CDK20.89331354
62ZAK0.88377528
63FGFR10.87795453
64STK160.86992878
65PAK20.85039579
66CLK10.84159453
67TLK10.83475876
68STK40.83367956
69DDR20.83111261
70LATS20.81736983
71MAPKAPK30.78724374
72PLK20.78560906
73NME20.77552437
74PLK40.77426496
75TESK10.77102104
76CSNK1G10.76711866
77BRSK10.76460436
78CAMK1G0.75914132
79AKT30.72000192
80PTK60.71840530
81DYRK30.71519111
82CSNK2A20.68030007
83CDK10.67780981
84BMPR1B0.65696961
85PIM10.64687239
86TRIM280.63712751
87CSNK1E0.62630444
88CDK80.62598246
89MAP3K30.62337182
90STK38L0.61669177
91WNK30.61467645
92MAPKAPK50.59869619
93MST1R0.59299267
94PRKDC0.57887268
95BRAF0.57418437
96PRKCI0.57176332
97CSNK1D0.56362914
98PDK40.55853225
99PDK30.55853225
100BCR0.51715964
101VRK10.51669483
102CSNK1G30.50594341
103CSNK1A1L0.50233058
104PAK10.48959867
105MKNK20.47890110
106STK390.46743366
107LIMK10.46137399
108CDK30.45072520
109AKT20.44222473
110FRK0.43873658
111CCNB10.43058493
112ERBB30.42475931
113BMX0.41957424
114RPS6KB10.41736190
115PDK20.40865674
116TRPM70.40227825
117MAP3K90.39966226
118CSNK2A10.39762836
119PDGFRB0.39296913
120MAPK140.38327744
121MAP3K40.36724986
122MAP2K30.36130084
123CSNK1G20.36117606
124YES10.34385540
125FER0.32001977
126AKT10.31758854
127CDK90.31758313
128PTK20.30878446
129CAMK1D0.30498984
130NLK0.30066265
131ERBB40.29658318
132MAPK10.27358701
133ILK0.24221494
134GSK3B0.23291870

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006704.02987056
2* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.92134866
3DNA replication_Homo sapiens_hsa030303.87444158
4Mismatch repair_Homo sapiens_hsa034303.77593793
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54048043
6RNA transport_Homo sapiens_hsa030133.42462543
7Spliceosome_Homo sapiens_hsa030402.95234014
8Cell cycle_Homo sapiens_hsa041102.61614983
9Nucleotide excision repair_Homo sapiens_hsa034202.44907208
10Base excision repair_Homo sapiens_hsa034102.28821781
11Non-homologous end-joining_Homo sapiens_hsa034502.23844528
12RNA polymerase_Homo sapiens_hsa030202.14774709
13Proteasome_Homo sapiens_hsa030502.11585521
14mRNA surveillance pathway_Homo sapiens_hsa030152.09712401
15Homologous recombination_Homo sapiens_hsa034402.00479870
16Ribosome_Homo sapiens_hsa030101.87343631
17RNA degradation_Homo sapiens_hsa030181.78116053
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.66319341
19Selenocompound metabolism_Homo sapiens_hsa004501.63922423
20Systemic lupus erythematosus_Homo sapiens_hsa053221.62558675
21Fanconi anemia pathway_Homo sapiens_hsa034601.58764575
22p53 signaling pathway_Homo sapiens_hsa041151.56174428
23Pyrimidine metabolism_Homo sapiens_hsa002401.50317372
24Pyruvate metabolism_Homo sapiens_hsa006201.49834528
25Viral carcinogenesis_Homo sapiens_hsa052031.48181371
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43624216
27Propanoate metabolism_Homo sapiens_hsa006401.38645451
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37236373
29Vitamin B6 metabolism_Homo sapiens_hsa007501.31924637
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24848135
31Biosynthesis of amino acids_Homo sapiens_hsa012301.24056761
32MicroRNAs in cancer_Homo sapiens_hsa052061.21273041
33Basal transcription factors_Homo sapiens_hsa030221.19303520
34Epstein-Barr virus infection_Homo sapiens_hsa051691.13386373
35Adherens junction_Homo sapiens_hsa045201.08809771
36Hippo signaling pathway_Homo sapiens_hsa043901.03710052
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01866855
38Antigen processing and presentation_Homo sapiens_hsa046121.01244264
39Steroid biosynthesis_Homo sapiens_hsa001000.97501449
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95582148
41Small cell lung cancer_Homo sapiens_hsa052220.94277874
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94056069
43Central carbon metabolism in cancer_Homo sapiens_hsa052300.93727569
44TGF-beta signaling pathway_Homo sapiens_hsa043500.92921895
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92054032
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91998044
47HTLV-I infection_Homo sapiens_hsa051660.89892605
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89017838
49Bladder cancer_Homo sapiens_hsa052190.88814333
50Oocyte meiosis_Homo sapiens_hsa041140.88680344
51Protein export_Homo sapiens_hsa030600.86860910
52Fatty acid elongation_Homo sapiens_hsa000620.86449816
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83181982
54mTOR signaling pathway_Homo sapiens_hsa041500.82795383
55Thyroid cancer_Homo sapiens_hsa052160.82528124
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80485183
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79709176
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76477537
59Legionellosis_Homo sapiens_hsa051340.74836114
60Chronic myeloid leukemia_Homo sapiens_hsa052200.74546892
61Alcoholism_Homo sapiens_hsa050340.73960978
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72785906
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72768924
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.70965627
65Carbon metabolism_Homo sapiens_hsa012000.70193888
66Basal cell carcinoma_Homo sapiens_hsa052170.69703578
67Proteoglycans in cancer_Homo sapiens_hsa052050.69551513
68Tight junction_Homo sapiens_hsa045300.69313952
69Colorectal cancer_Homo sapiens_hsa052100.68964221
70Purine metabolism_Homo sapiens_hsa002300.68700093
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.67688388
72Focal adhesion_Homo sapiens_hsa045100.60578612
73N-Glycan biosynthesis_Homo sapiens_hsa005100.59259989
74ECM-receptor interaction_Homo sapiens_hsa045120.58167545
75Herpes simplex infection_Homo sapiens_hsa051680.57648524
76Notch signaling pathway_Homo sapiens_hsa043300.57538713
77Prostate cancer_Homo sapiens_hsa052150.57280534
78Huntingtons disease_Homo sapiens_hsa050160.56063923
79Fatty acid metabolism_Homo sapiens_hsa012120.56022894
80HIF-1 signaling pathway_Homo sapiens_hsa040660.54506233
81Apoptosis_Homo sapiens_hsa042100.53533311
82Viral myocarditis_Homo sapiens_hsa054160.51982920
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48918538
84Lysine degradation_Homo sapiens_hsa003100.48296145
85Glutathione metabolism_Homo sapiens_hsa004800.45969417
86Pathways in cancer_Homo sapiens_hsa052000.45300664
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.45253950
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44305106
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42643167
90Melanoma_Homo sapiens_hsa052180.42474928
91Parkinsons disease_Homo sapiens_hsa050120.40207932
92Metabolic pathways_Homo sapiens_hsa011000.39354901
93Endometrial cancer_Homo sapiens_hsa052130.37472758
94Galactose metabolism_Homo sapiens_hsa000520.37373169
95Hedgehog signaling pathway_Homo sapiens_hsa043400.36720117
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36499741
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.34991345
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34738557
99Pentose phosphate pathway_Homo sapiens_hsa000300.34554744
100Hepatitis B_Homo sapiens_hsa051610.33954088
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33159571
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32958394
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32177614
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31128881
105Pancreatic cancer_Homo sapiens_hsa052120.31119499
106Arginine and proline metabolism_Homo sapiens_hsa003300.30696303
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29850877
108AMPK signaling pathway_Homo sapiens_hsa041520.29675715
109Non-small cell lung cancer_Homo sapiens_hsa052230.29147439
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.28616190
111Fructose and mannose metabolism_Homo sapiens_hsa000510.28499090
112Shigellosis_Homo sapiens_hsa051310.28074136
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27865731
114Arginine biosynthesis_Homo sapiens_hsa002200.26330682
115FoxO signaling pathway_Homo sapiens_hsa040680.25405888
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24298003
117Wnt signaling pathway_Homo sapiens_hsa043100.23749529
118Oxidative phosphorylation_Homo sapiens_hsa001900.23542189
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23486171
120Renin-angiotensin system_Homo sapiens_hsa046140.23181235
121Glucagon signaling pathway_Homo sapiens_hsa049220.22348575
122Folate biosynthesis_Homo sapiens_hsa007900.21901260
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20484298
124Butanoate metabolism_Homo sapiens_hsa006500.19466450
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19137292
126Sulfur metabolism_Homo sapiens_hsa009200.17944179
127Acute myeloid leukemia_Homo sapiens_hsa052210.16246826
128Alzheimers disease_Homo sapiens_hsa050100.14232922
129Fatty acid biosynthesis_Homo sapiens_hsa000610.13986006
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11521969
131beta-Alanine metabolism_Homo sapiens_hsa004100.08405920
132Fatty acid degradation_Homo sapiens_hsa000710.07266313
133Thyroid hormone synthesis_Homo sapiens_hsa049180.07130183

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