LARS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.52966323
2DNA strand elongation involved in DNA replication (GO:0006271)4.99232964
3mitotic chromosome condensation (GO:0007076)4.95251334
4DNA strand elongation (GO:0022616)4.92676957
5establishment of integrated proviral latency (GO:0075713)4.78015160
6protein localization to chromosome, centromeric region (GO:0071459)4.55616073
7protein localization to kinetochore (GO:0034501)4.41361557
8DNA replication initiation (GO:0006270)4.40434873
9cytoplasmic mRNA processing body assembly (GO:0033962)4.28445966
10mitotic sister chromatid segregation (GO:0000070)4.27454365
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.18816358
12protein complex localization (GO:0031503)4.16273634
13mitotic metaphase plate congression (GO:0007080)4.08175721
14mitotic nuclear envelope disassembly (GO:0007077)4.06867588
15sister chromatid segregation (GO:0000819)4.05316492
16L-serine metabolic process (GO:0006563)3.99586667
17nuclear envelope disassembly (GO:0051081)3.89996390
18membrane disassembly (GO:0030397)3.89996390
19mitotic sister chromatid cohesion (GO:0007064)3.89902355
20* regulation of translational fidelity (GO:0006450)3.89751686
21heterochromatin organization (GO:0070828)3.84412038
22formation of translation preinitiation complex (GO:0001731)3.71434578
23cellular protein complex localization (GO:0034629)3.66579178
24IMP biosynthetic process (GO:0006188)3.65593415
25positive regulation of chromosome segregation (GO:0051984)3.63957984
26telomere maintenance via semi-conservative replication (GO:0032201)3.62340288
27DNA duplex unwinding (GO:0032508)3.60625573
28IMP metabolic process (GO:0046040)3.50252557
29NLS-bearing protein import into nucleus (GO:0006607)3.45722887
30DNA geometric change (GO:0032392)3.41916848
31establishment of viral latency (GO:0019043)3.41457531
32proline biosynthetic process (GO:0006561)3.37068940
33nuclear pore complex assembly (GO:0051292)3.34661823
34metaphase plate congression (GO:0051310)3.32222028
35DNA replication checkpoint (GO:0000076)3.29094604
36chromatin assembly (GO:0031497)3.29024655
37regulation of sister chromatid cohesion (GO:0007063)3.28322153
38CENP-A containing nucleosome assembly (GO:0034080)3.28204519
39ribosome assembly (GO:0042255)3.27950257
40chromatin remodeling at centromere (GO:0031055)3.25593023
41regulation of mitotic spindle organization (GO:0060236)3.24041238
42DNA topological change (GO:0006265)3.23808366
43folic acid-containing compound biosynthetic process (GO:0009396)3.22320244
44positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.18357734
45regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.18357734
46peptidyl-arginine omega-N-methylation (GO:0035247)3.18323951
47chromosome condensation (GO:0030261)3.17783267
48chromatin assembly or disassembly (GO:0006333)3.15881572
49DNA replication-independent nucleosome assembly (GO:0006336)3.15693079
50DNA replication-independent nucleosome organization (GO:0034724)3.15693079
51regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15574251
52histone H3-K4 trimethylation (GO:0080182)3.14293401
53negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.14225362
54negative regulation of translation, ncRNA-mediated (GO:0040033)3.14225362
55regulation of translation, ncRNA-mediated (GO:0045974)3.14225362
56spliceosomal tri-snRNP complex assembly (GO:0000244)3.13743250
57regulation of spindle organization (GO:0090224)3.12342706
58non-recombinational repair (GO:0000726)3.12240599
59double-strand break repair via nonhomologous end joining (GO:0006303)3.12240599
60nucleobase biosynthetic process (GO:0046112)3.11757845
61regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.10354365
62positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.10354365
63establishment of chromosome localization (GO:0051303)3.09459154
64histone arginine methylation (GO:0034969)3.09299337
65DNA conformation change (GO:0071103)3.08237363
66nuclear envelope organization (GO:0006998)3.07132604
67telomere maintenance via recombination (GO:0000722)3.05690030
68ATP-dependent chromatin remodeling (GO:0043044)3.05609762
69regulation of chromosome segregation (GO:0051983)3.04696056
70serine family amino acid biosynthetic process (GO:0009070)3.03270759
71hemidesmosome assembly (GO:0031581)3.01813798
72mitotic recombination (GO:0006312)2.99421251
73regulation of translational termination (GO:0006449)2.98625330
74purine nucleobase biosynthetic process (GO:0009113)2.96218800
75negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.93165368
76glucocorticoid receptor signaling pathway (GO:0042921)2.91156865
77retrograde transport, vesicle recycling within Golgi (GO:0000301)2.89067174
78insulin-like growth factor receptor signaling pathway (GO:0048009)2.87851231
79establishment of apical/basal cell polarity (GO:0035089)2.84714590
80nucleobase-containing small molecule interconversion (GO:0015949)2.84660229
81DNA replication-dependent nucleosome assembly (GO:0006335)2.82850829
82DNA replication-dependent nucleosome organization (GO:0034723)2.82850829
83maturation of SSU-rRNA (GO:0030490)2.81331781
84pre-miRNA processing (GO:0031054)2.80951886
85ribosome biogenesis (GO:0042254)2.78088770
86RNA stabilization (GO:0043489)2.77798139
87mRNA stabilization (GO:0048255)2.77798139
88protein localization to chromosome (GO:0034502)2.76080558
89protein export from nucleus (GO:0006611)2.75373149
90negative regulation of chromosome segregation (GO:0051985)2.74865777
91protein-DNA complex disassembly (GO:0032986)2.73331018
92nucleosome disassembly (GO:0006337)2.73331018
93DNA packaging (GO:0006323)2.71530597
94peptidyl-arginine N-methylation (GO:0035246)2.71508189
95peptidyl-arginine methylation (GO:0018216)2.71508189
96hippo signaling (GO:0035329)2.71459793
97histone H3-K4 methylation (GO:0051568)2.70482026
98chromosome segregation (GO:0007059)2.68960808
99bundle of His cell to Purkinje myocyte communication (GO:0086069)2.68858016
100regulation of centrosome cycle (GO:0046605)2.68191110
101mitochondrial DNA metabolic process (GO:0032042)2.66889940
102negative regulation of cell killing (GO:0031342)2.66782745
103negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.66782745
104nuclear pore organization (GO:0006999)2.66781499
105regulation of gene silencing by RNA (GO:0060966)2.66093671
106regulation of posttranscriptional gene silencing (GO:0060147)2.66093671
107regulation of gene silencing by miRNA (GO:0060964)2.66093671
108regulation of NFAT protein import into nucleus (GO:0051532)2.65554557
109plasma membrane repair (GO:0001778)2.64026767
110regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.62899705
111regulation of mitotic metaphase/anaphase transition (GO:0030071)2.62899705
112corticosteroid receptor signaling pathway (GO:0031958)2.62357579
113negative regulation of mitotic sister chromatid segregation (GO:0033048)2.61923509
114negative regulation of sister chromatid segregation (GO:0033046)2.61923509
115cerebellar Purkinje cell differentiation (GO:0021702)2.59818398
116regulation of RNA export from nucleus (GO:0046831)2.56744418
117desmosome organization (GO:0002934)2.55659670
118cell-substrate junction assembly (GO:0007044)2.54978599
119heart morphogenesis (GO:0003007)2.51316896
120regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.50145609
121axon extension involved in axon guidance (GO:0048846)2.47442787
122neuron projection extension involved in neuron projection guidance (GO:1902284)2.47442787
123cytoskeletal anchoring at plasma membrane (GO:0007016)2.46616989
124semaphorin-plexin signaling pathway (GO:0071526)2.45965630
125planar cell polarity pathway involved in neural tube closure (GO:0090179)2.42974745
126establishment of protein localization to Golgi (GO:0072600)2.40639343
127neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.38543397
128pore complex assembly (GO:0046931)2.37361592
129peptidyl-lysine trimethylation (GO:0018023)2.35496598
130embryonic retina morphogenesis in camera-type eye (GO:0060059)2.34998218
131protein targeting to Golgi (GO:0000042)2.33374331
132positive regulation of mRNA catabolic process (GO:0061014)2.31197617
133regulation of DNA endoreduplication (GO:0032875)2.30061111
134epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.29918825
135regulation of mRNA catabolic process (GO:0061013)2.29250866
136stress granule assembly (GO:0034063)2.27921831
137positive regulation of histone deacetylation (GO:0031065)2.26917913
138positive regulation of cardiac muscle cell differentiation (GO:2000727)2.26239765
139regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.26177920
140sodium ion export (GO:0071436)2.24871761
141response to UV-C (GO:0010225)2.23692639
142embryonic viscerocranium morphogenesis (GO:0048703)2.23253125
143regulation of nucleobase-containing compound transport (GO:0032239)2.21975645
144radial glial cell differentiation (GO:0060019)2.21260448
145positive regulation of hormone biosynthetic process (GO:0046886)2.19926514
146regulation of p38MAPK cascade (GO:1900744)2.19842787
147positive regulation of p38MAPK cascade (GO:1900745)2.19333060
148cardiac myofibril assembly (GO:0055003)2.19111493
149regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.18565906
150coronary vasculature morphogenesis (GO:0060977)2.18133219
151cell adhesion mediated by integrin (GO:0033627)2.17784098
152positive regulation of tolerance induction (GO:0002645)2.15989230
153apoptotic process involved in morphogenesis (GO:0060561)2.13098635
154adherens junction assembly (GO:0034333)2.13047582
155histone lysine methylation (GO:0034968)2.12704649
156neural tube closure (GO:0001843)2.12270523
157wound healing, spreading of epidermal cells (GO:0035313)2.10848967
158tube closure (GO:0060606)2.10386556
159antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.10056453
160cell-substrate adherens junction assembly (GO:0007045)2.09873368
161focal adhesion assembly (GO:0048041)2.09873368
162I-kappaB phosphorylation (GO:0007252)2.08805817
163chondrocyte development (GO:0002063)2.08771812
164artery development (GO:0060840)2.08285399
165positive T cell selection (GO:0043368)2.07614420
166positive thymic T cell selection (GO:0045059)2.07283271
167gastrulation with mouth forming second (GO:0001702)2.07220939
168head development (GO:0060322)2.06323632
169regulation of clathrin-mediated endocytosis (GO:2000369)2.05263355
170histone H3-K36 demethylation (GO:0070544)2.04717385
171establishment of nucleus localization (GO:0040023)2.04629130
172negative regulation of histone methylation (GO:0031061)2.02876617
173negative regulation of catenin import into nucleus (GO:0035414)2.02477324
174lateral sprouting from an epithelium (GO:0060601)2.02296180
175regulation of histone H3-K9 methylation (GO:0051570)2.01026052
176paraxial mesoderm development (GO:0048339)1.99988086
177histone lysine demethylation (GO:0070076)1.99253206
178positive regulation of SMAD protein import into nucleus (GO:0060391)1.96999589
179peptidyl-threonine phosphorylation (GO:0018107)1.96848318
180regulation of establishment of planar polarity (GO:0090175)1.96648864
181histone H3-K9 demethylation (GO:0033169)1.95733452
182positive regulation by symbiont of host defense response (GO:0052509)1.95648322
183modulation by symbiont of host defense response (GO:0052031)1.95648322
184modulation by organism of immune response of other organism involved in symbiotic interaction (GO:001.95648322
185modulation by organism of defense response of other organism involved in symbiotic interaction (GO:01.95648322
186positive regulation by organism of defense response of other organism involved in symbiotic interact1.95648322
187modulation by symbiont of host immune response (GO:0052553)1.95648322
188nucleus localization (GO:0051647)1.93330408
189somatic stem cell division (GO:0048103)1.93259770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.18103658
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.25937241
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.52463870
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.52191932
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.45228329
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.37322292
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.23785641
8AR_21909140_ChIP-Seq_LNCAP_Human3.11565091
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.07533957
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.00280712
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93764598
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.87028210
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82843866
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61624547
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.46329245
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.45907147
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44594825
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.37470703
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.31750087
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.27780494
21XRN2_22483619_ChIP-Seq_HELA_Human2.21283190
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19944081
23TP53_16413492_ChIP-PET_HCT116_Human2.12508459
24ZFX_18555785_ChIP-Seq_MESCs_Mouse2.12078109
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.08884121
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07042026
27ZNF217_24962896_ChIP-Seq_MCF-7_Human2.03234573
28* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03211802
29MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02833525
30ZNF263_19887448_ChIP-Seq_K562_Human1.96975354
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96259479
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94533836
33* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91117350
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.82943661
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81178745
36* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79674332
37* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79670305
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78614974
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76634097
40* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75627752
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.74143785
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.72222238
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70933642
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68939404
45TTF2_22483619_ChIP-Seq_HELA_Human1.67135744
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.66960559
47DCP1A_22483619_ChIP-Seq_HELA_Human1.65203799
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.64143096
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63693722
50AR_21572438_ChIP-Seq_LNCaP_Human1.63102230
51* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.62784806
52DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.60667328
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.58084445
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56224772
55* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56043274
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55966607
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54459217
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53547061
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51617605
60AHR_22903824_ChIP-Seq_MCF-7_Human1.51409445
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50741348
62KDM2B_26808549_Chip-Seq_DND41_Human1.50101438
63* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49987647
64TCF7_22412390_ChIP-Seq_EML_Mouse1.49746896
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49541032
66ISL1_27105846_Chip-Seq_CPCs_Mouse1.48298691
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46643013
68EZH2_22144423_ChIP-Seq_EOC_Human1.45391578
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43724445
70CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43382881
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42549648
72* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42228031
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.41592496
74CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.39972528
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.39831578
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.38159291
77DROSHA_22980978_ChIP-Seq_HELA_Human1.37939429
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37347571
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36170980
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35425654
81GABP_19822575_ChIP-Seq_HepG2_Human1.35046654
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.34986938
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33266321
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.32527211
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32044543
86BRD4_25478319_ChIP-Seq_HGPS_Human1.32029128
87* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31595046
88* EP300_21415370_ChIP-Seq_HL-1_Mouse1.31382079
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30353924
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30108292
91* TCF4_18268006_ChIP-ChIP_LS174T_Human1.29532837
92* FOXO3_23340844_ChIP-Seq_DLD1_Human1.28973087
93ESR1_21235772_ChIP-Seq_MCF-7_Human1.28605120
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.27873206
95EST1_17652178_ChIP-ChIP_JURKAT_Human1.27545305
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24916535
97CLOCK_20551151_ChIP-Seq_293T_Human1.23810908
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22911139
99KDM5A_27292631_Chip-Seq_BREAST_Human1.21365012
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20790163
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19681544
102KDM2B_26808549_Chip-Seq_K562_Human1.19387041
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19259134
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19259134
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19259134
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18875748
107E2F7_22180533_ChIP-Seq_HELA_Human1.17468774
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17446713
109RXR_22108803_ChIP-Seq_LS180_Human1.16132337
110CHD1_26751641_Chip-Seq_LNCaP_Human1.14469694
111SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14451806
112* YY1_21170310_ChIP-Seq_MESCs_Mouse1.14164585
113SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13851462
114P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12967069
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12882652
116RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12447697
117CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11609932
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11498166
119NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10677327
120SALL1_21062744_ChIP-ChIP_HESCs_Human1.10459271
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09416791
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09197342
123NANOG_21062744_ChIP-ChIP_HESCs_Human1.09151511
124* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09050159
125* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08918232
126* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08386068
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07698962
128* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07226689
129PIAS1_25552417_ChIP-Seq_VCAP_Human1.06726164
130FOXP3_21729870_ChIP-Seq_TREG_Human1.06501303
131SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05712944
132SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05712944
133* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05322842
134* SPI1_23127762_ChIP-Seq_K562_Human1.05106902
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04301433
136FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03947253
137NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03913306
138TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03621423
139ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03204472
140SOX17_20123909_ChIP-Seq_XEN_Mouse1.03067622
141KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01922217
142KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01478670
143TP53_18474530_ChIP-ChIP_U2OS_Human1.00448225
144PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00319693
145AR_19668381_ChIP-Seq_PC3_Human1.00204634
146RUNX1_27514584_Chip-Seq_MCF-7_Human1.00007360
147BCAT_22108803_ChIP-Seq_LS180_Human0.99498874
148HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98580800
149WT1_19549856_ChIP-ChIP_CCG9911_Human0.98512047
150MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98487968
151SMAD4_21799915_ChIP-Seq_A2780_Human0.98364831
152ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97389477
153GABP_17652178_ChIP-ChIP_JURKAT_Human0.97155532
154SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97113010
155SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97004237
156TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96641385
157NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96554894
158TFEB_21752829_ChIP-Seq_HELA_Human0.96202365
159KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95980640
160PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95768483
161FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95709932
162PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95575049
163TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95502891
164POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95426705
165TBX20_22328084_ChIP-Seq_HEART_Mouse0.95015533
166TBX20_22080862_ChIP-Seq_HEART_Mouse0.95015533
167NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94444548
168ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94138973
169TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93876537
170TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93674854
171RNF2_27304074_Chip-Seq_ESCs_Mouse0.93433043
172RUNX_20019798_ChIP-Seq_JUKART_Human0.93323569
173MYC_22102868_ChIP-Seq_BL_Human0.92547626
174DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91632362
175ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91592884
176ELK1_19687146_ChIP-ChIP_HELA_Human0.91422470
177BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91291674
178FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91146816
179HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90995794
180VDR_24787735_ChIP-Seq_THP-1_Human0.90933826
181TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90739510
182POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90739510
183OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88560528
184NANOG_16153702_ChIP-ChIP_HESCs_Human0.88543445
185* CIITA_25753668_ChIP-Seq_RAJI_Human0.87425798
186TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86760967
187SOX2_16153702_ChIP-ChIP_HESCs_Human0.85715131

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.00404398
2MP0003693_abnormal_embryo_hatching4.14813363
3MP0003111_abnormal_nucleus_morphology3.93976199
4MP0010094_abnormal_chromosome_stability3.86125955
5MP0004957_abnormal_blastocyst_morpholog3.76967185
6MP0005076_abnormal_cell_differentiation3.16709192
7MP0003077_abnormal_cell_cycle3.07965027
8MP0008932_abnormal_embryonic_tissue2.88349689
9MP0008057_abnormal_DNA_replication2.81059137
10MP0010352_gastrointestinal_tract_polyps2.62399697
11MP0001730_embryonic_growth_arrest2.60971033
12MP0003300_gastrointestinal_ulcer2.48295290
13MP0003705_abnormal_hypodermis_morpholog2.32326858
14MP0008058_abnormal_DNA_repair2.25516457
15MP0003045_fibrosis2.18511002
16MP0001299_abnormal_eye_distance/2.08905639
17MP0003890_abnormal_embryonic-extraembry2.08357248
18MP0000350_abnormal_cell_proliferation2.07909217
19MP0003828_pulmonary_edema2.07806608
20MP0005503_abnormal_tendon_morphology2.04450207
21MP0010234_abnormal_vibrissa_follicle2.01652779
22MP0003566_abnormal_cell_adhesion1.95137680
23MP0009672_abnormal_birth_weight1.89208665
24MP0008007_abnormal_cellular_replicative1.87965310
25MP0002877_abnormal_melanocyte_morpholog1.84304173
26MP0005187_abnormal_penis_morphology1.84011451
27MP0005623_abnormal_meninges_morphology1.80892602
28MP0004272_abnormal_basement_membrane1.78522631
29MP0000383_abnormal_hair_follicle1.77231201
30MP0000733_abnormal_muscle_development1.71464802
31MP0010678_abnormal_skin_adnexa1.70956326
32MP0002080_prenatal_lethality1.68061068
33MP0005275_abnormal_skin_tensile1.66900731
34MP0001697_abnormal_embryo_size1.65785282
35MP0002697_abnormal_eye_size1.65698413
36MP0003315_abnormal_perineum_morphology1.63577450
37MP0003718_maternal_effect1.59447578
38MP0001346_abnormal_lacrimal_gland1.53763554
39MP0003091_abnormal_cell_migration1.53229085
40MP0004808_abnormal_hematopoietic_stem1.51685087
41MP0000537_abnormal_urethra_morphology1.51345647
42MP0002009_preneoplasia1.49431883
43MP0000428_abnormal_craniofacial_morphol1.46495139
44MP0009697_abnormal_copulation1.45357045
45MP0005409_darkened_coat_color1.41791957
46MP0009384_cardiac_valve_regurgitation1.41683996
47MP0004185_abnormal_adipocyte_glucose1.40610733
48MP0010307_abnormal_tumor_latency1.40124094
49MP0003136_yellow_coat_color1.39226625
50MP0003279_aneurysm1.34806304
51MP0004084_abnormal_cardiac_muscle1.34391498
52MP0008961_abnormal_basal_metabolism1.34261697
53MP0004233_abnormal_muscle_weight1.33954032
54MP0009278_abnormal_bone_marrow1.31528649
55MP0001661_extended_life_span1.28885237
56MP0002254_reproductive_system_inflammat1.28533788
57MP0010630_abnormal_cardiac_muscle1.26942466
58MP0002396_abnormal_hematopoietic_system1.24558369
59MP0000427_abnormal_hair_cycle1.23289294
60MP0002092_abnormal_eye_morphology1.23087652
61MP0003567_abnormal_fetal_cardiomyocyte1.22754495
62MP0002925_abnormal_cardiovascular_devel1.21676227
63MP0004510_myositis1.21575207
64MP0008438_abnormal_cutaneous_collagen1.21269732
65MP0003935_abnormal_craniofacial_develop1.19906361
66MP0003123_paternal_imprinting1.19155474
67MP0000750_abnormal_muscle_regeneration1.19126606
68MP0003115_abnormal_respiratory_system1.16922692
69MP0000751_myopathy1.16498450
70MP0001849_ear_inflammation1.16275437
71MP0003303_peritoneal_inflammation1.16254842
72MP0000313_abnormal_cell_death1.15618543
73MP0005257_abnormal_intraocular_pressure1.15414918
74MP0003121_genomic_imprinting1.15333100
75MP0000432_abnormal_head_morphology1.14690047
76MP0002108_abnormal_muscle_morphology1.14602634
77MP0005451_abnormal_body_composition1.14513338
78MP0001958_emphysema1.14388066
79MP0000579_abnormal_nail_morphology1.12845923
80MP0005248_abnormal_Harderian_gland1.11912929
81MP0002166_altered_tumor_susceptibility1.11538958
82MP0004947_skin_inflammation1.08622652
83MP0003122_maternal_imprinting1.07833005
84MP0004197_abnormal_fetal_growth/weight/1.06979673
85MP0005023_abnormal_wound_healing1.06972802
86MP0005367_renal/urinary_system_phenotyp1.05435727
87MP0000516_abnormal_urinary_system1.05435727
88MP0000762_abnormal_tongue_morphology1.03872225
89MP0002111_abnormal_tail_morphology1.03801847
90MP0002006_tumorigenesis1.03328295
91MP0006035_abnormal_mitochondrial_morpho1.03234880
92MP0001286_abnormal_eye_development1.02134009
93MP0009053_abnormal_anal_canal1.00400438
94MP0002084_abnormal_developmental_patter1.00078262
95MP0000358_abnormal_cell_content/0.99994249
96MP0009703_decreased_birth_body0.99827913
97MP0005508_abnormal_skeleton_morphology0.98904609
98MP0000266_abnormal_heart_morphology0.98313128
99MP0004087_abnormal_muscle_fiber0.98172136
100MP0005174_abnormal_tail_pigmentation0.96118127
101MP0002086_abnormal_extraembryonic_tissu0.95125490
102MP0004858_abnormal_nervous_system0.94020539
103MP0006292_abnormal_olfactory_placode0.92371279
104MP0001293_anophthalmia0.91880431
105MP0003786_premature_aging0.91767014
106MP0003937_abnormal_limbs/digits/tail_de0.91430147
107MP0003942_abnormal_urinary_system0.91065155
108MP0005621_abnormal_cell_physiology0.90237729
109MP0000490_abnormal_crypts_of0.90132542
110MP0003861_abnormal_nervous_system0.89893794
111MP0002233_abnormal_nose_morphology0.89585207
112MP0008770_decreased_survivor_rate0.89544129
113MP0004264_abnormal_extraembryonic_tissu0.89457295
114MP0000767_abnormal_smooth_muscle0.89333022
115MP0001851_eye_inflammation0.89000379
116MP0003221_abnormal_cardiomyocyte_apopto0.88195934
117MP0008877_abnormal_DNA_methylation0.87969993
118MP0005384_cellular_phenotype0.87740697
119MP0002088_abnormal_embryonic_growth/wei0.87609758
120MP0003385_abnormal_body_wall0.87377971
121MP0002282_abnormal_trachea_morphology0.87042623
122MP0003787_abnormal_imprinting0.86101009
123MP0002089_abnormal_postnatal_growth/wei0.85415499
124MP0003984_embryonic_growth_retardation0.85132352
125MP0010030_abnormal_orbit_morphology0.85060912
126MP0000566_synostosis0.84485164
127MP0003453_abnormal_keratinocyte_physiol0.84457645
128MP0001915_intracranial_hemorrhage0.83855918
129MP0005501_abnormal_skin_physiology0.83797735
130MP0002896_abnormal_bone_mineralization0.83505326
131MP0002837_dystrophic_cardiac_calcinosis0.83154908
132MP0003755_abnormal_palate_morphology0.82975507
133MP0004134_abnormal_chest_morphology0.82818425
134MP0000377_abnormal_hair_follicle0.82390401
135MP0004484_altered_response_of0.80735061
136MP0001784_abnormal_fluid_regulation0.80215827
137MP0002168_other_aberrant_phenotype0.79086251
138MP0002085_abnormal_embryonic_tissue0.78982411
139MP0000747_muscle_weakness0.77688969
140MP0003941_abnormal_skin_development0.76502607
141MP0000371_diluted_coat_color0.76321378
142MP0002234_abnormal_pharynx_morphology0.76263073
143MP0001672_abnormal_embryogenesis/_devel0.74738044
144MP0005380_embryogenesis_phenotype0.74738044
145MP0002796_impaired_skin_barrier0.74590042
146MP0000534_abnormal_ureter_morphology0.74387750
147MP0002109_abnormal_limb_morphology0.73770766
148MP0001340_abnormal_eyelid_morphology0.73247187
149MP0002098_abnormal_vibrissa_morphology0.72270882
150MP0002269_muscular_atrophy0.64667568
151MP0005197_abnormal_uvea_morphology0.62383537
152MP0000627_abnormal_mammary_gland0.61935483
153MP0003119_abnormal_digestive_system0.61934261
154MP0002114_abnormal_axial_skeleton0.61498854
155MP0008260_abnormal_autophagy0.61083288

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.68281212
2Short 4th metacarpal (HP:0010044)3.64082783
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.64082783
4Chromsome breakage (HP:0040012)3.48444435
5Urethral obstruction (HP:0000796)3.46937185
6Abnormality of the fingertips (HP:0001211)3.22165317
7Abnormality of the nasal septum (HP:0000419)3.18651194
8Shallow orbits (HP:0000586)2.96139601
9Long eyelashes (HP:0000527)2.89667011
10Multiple enchondromatosis (HP:0005701)2.89037552
11Narrow palate (HP:0000189)2.84560464
12Trigonocephaly (HP:0000243)2.78837106
13Abnormality of glycolysis (HP:0004366)2.74262460
14Insomnia (HP:0100785)2.71247340
15Progressive muscle weakness (HP:0003323)2.67826906
16Distal lower limb amyotrophy (HP:0008944)2.61386995
17Overriding aorta (HP:0002623)2.60056151
18Selective tooth agenesis (HP:0001592)2.59863738
19Volvulus (HP:0002580)2.55301751
20Abnormality of the 4th metacarpal (HP:0010012)2.54962005
21Microvesicular hepatic steatosis (HP:0001414)2.53436285
22Cortical dysplasia (HP:0002539)2.50938711
23Spastic diplegia (HP:0001264)2.45575895
24Macroorchidism (HP:0000053)2.45143889
25Birth length less than 3rd percentile (HP:0003561)2.42059603
26Midline defect of the nose (HP:0004122)2.41950383
27Hypoplastic ischia (HP:0003175)2.39293936
28Nephroblastoma (Wilms tumor) (HP:0002667)2.38669588
29Genetic anticipation (HP:0003743)2.37272555
30Hyporeflexia of lower limbs (HP:0002600)2.36495847
31Increased serum pyruvate (HP:0003542)2.34165787
32Renal duplication (HP:0000075)2.31581051
33Protrusio acetabuli (HP:0003179)2.29833107
34Progressive external ophthalmoplegia (HP:0000590)2.28769668
35Large earlobe (HP:0009748)2.27874383
36Facial cleft (HP:0002006)2.27080212
37Elfin facies (HP:0004428)2.26493647
38Absent frontal sinuses (HP:0002688)2.25867831
39Cerebral aneurysm (HP:0004944)2.24921276
40Meckel diverticulum (HP:0002245)2.24394784
41Insidious onset (HP:0003587)2.24179426
42Termporal pattern (HP:0011008)2.24179426
43Aortic aneurysm (HP:0004942)2.18608477
44Lower limb amyotrophy (HP:0007210)2.17480118
45Embryonal renal neoplasm (HP:0011794)2.16620268
46Broad metatarsal (HP:0001783)2.13849505
47Depressed nasal tip (HP:0000437)2.13522234
48Anal stenosis (HP:0002025)2.13342852
49Oligodontia (HP:0000677)2.12600290
50Hypoplastic labia majora (HP:0000059)2.11503711
51Duplication of thumb phalanx (HP:0009942)2.11277091
52Limited elbow extension (HP:0001377)2.11161572
53Abnormality of the ileum (HP:0001549)2.09868753
54Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.09728334
55Missing ribs (HP:0000921)2.09334389
56Abnormality of the ischium (HP:0003174)2.09288937
57Abnormality of the parietal bone (HP:0002696)2.04869694
58Supernumerary ribs (HP:0005815)2.04084267
59Abnormal lung lobation (HP:0002101)2.03380479
60High anterior hairline (HP:0009890)2.02798580
61Back pain (HP:0003418)2.00608526
62Abnormality of the preputium (HP:0100587)2.00545753
63Heterotopia (HP:0002282)1.99952795
64Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99630406
65Broad thumb (HP:0011304)1.98220352
66Aplasia cutis congenita (HP:0001057)1.97640664
67Renovascular hypertension (HP:0100817)1.97490288
68Ankle contracture (HP:0006466)1.97464482
69Abnormal gallbladder physiology (HP:0012438)1.96526211
70Cholecystitis (HP:0001082)1.96526211
71Genu recurvatum (HP:0002816)1.95108906
72Abnormality of the salivary glands (HP:0010286)1.94622846
73Aqueductal stenosis (HP:0002410)1.92961458
74Sparse lateral eyebrow (HP:0005338)1.92878977
75Obsessive-compulsive behavior (HP:0000722)1.92397568
76Absent radius (HP:0003974)1.92147753
77Overlapping toe (HP:0001845)1.90845941
78Pseudobulbar signs (HP:0002200)1.90406095
79Abnormality of the labia majora (HP:0012881)1.90070002
80Milia (HP:0001056)1.89985015
81Abnormality of the calcaneus (HP:0008364)1.89716278
82Abnormality of the carotid arteries (HP:0005344)1.89449255
83Abnormality of the columella (HP:0009929)1.88739280
84Hematochezia (HP:0002573)1.88609727
85Mitral valve prolapse (HP:0001634)1.88453688
86Increased connective tissue (HP:0009025)1.87489917
87Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87426473
88Abnormality of cochlea (HP:0000375)1.86164887
89Dislocated radial head (HP:0003083)1.85216039
90Relative macrocephaly (HP:0004482)1.85182377
91Prominent nose (HP:0000448)1.85152537
92Abnormality of the distal phalanx of the thumb (HP:0009617)1.83019885
93Trismus (HP:0000211)1.82532812
94Aneurysm (HP:0002617)1.80978515
95Partial duplication of thumb phalanx (HP:0009944)1.80728084
96Abnormality of chromosome stability (HP:0003220)1.80572572
97Hyperacusis (HP:0010780)1.80017808
98Abnormality of the radial head (HP:0003995)1.78416281
99Absent forearm bone (HP:0003953)1.77853497
100Aplasia involving forearm bones (HP:0009822)1.77853497
101Choanal stenosis (HP:0000452)1.76725898
102Hepatoblastoma (HP:0002884)1.76020269
103Reticulocytopenia (HP:0001896)1.76016850
104Low anterior hairline (HP:0000294)1.76011992
105Truncal obesity (HP:0001956)1.75822049
106Ulnar bowing (HP:0003031)1.75437519
107Atrophic scars (HP:0001075)1.75310776
108Shoulder girdle muscle weakness (HP:0003547)1.74817852
109Arnold-Chiari malformation (HP:0002308)1.74768360
110Hypoplasia of the maxilla (HP:0000327)1.74130918
111Neoplasm of the oral cavity (HP:0100649)1.74060636
112Supernumerary bones of the axial skeleton (HP:0009144)1.73952759
113Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73511676
114Absent epiphyses (HP:0010577)1.73511676
115Abnormality of the epiphyses of the hand (HP:0005924)1.73461555
116Increased density of long bones (HP:0006392)1.73422415
117Aplasia/Hypoplasia of the uvula (HP:0010293)1.72906132
118Rectal prolapse (HP:0002035)1.72536153
119Skull defect (HP:0001362)1.71293222
120Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.70368533
121Uterine leiomyosarcoma (HP:0002891)1.70241660
122Leiomyosarcoma (HP:0100243)1.70241660
123Increased nuchal translucency (HP:0010880)1.70117984
124Broad hallux (HP:0010055)1.69848406
125Short phalanx of the thumb (HP:0009660)1.69392676
126Partial agenesis of the corpus callosum (HP:0001338)1.69323085
127Abnormality of oral frenula (HP:0000190)1.68832958
128Lip pit (HP:0100267)1.68465825
129Flat cornea (HP:0007720)1.68105395
130Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.67869746
131Skin tags (HP:0010609)1.67819635
132Advanced eruption of teeth (HP:0006288)1.67735875
133Deviation of the thumb (HP:0009603)1.67286212
134Chin dimple (HP:0010751)1.66817054
135Proximal placement of thumb (HP:0009623)1.66293627
136Ureteral obstruction (HP:0006000)1.66087101
137Small intestinal stenosis (HP:0012848)1.65675931
138Duodenal stenosis (HP:0100867)1.65675931
139Smooth philtrum (HP:0000319)1.65486699
140Ankyloglossia (HP:0010296)1.64548810
141Deep philtrum (HP:0002002)1.64488153
142Submucous cleft hard palate (HP:0000176)1.63712919
143Overgrowth (HP:0001548)1.62373354
144Gastrointestinal carcinoma (HP:0002672)1.62251001
145Malignant gastrointestinal tract tumors (HP:0006749)1.62251001
146Sparse scalp hair (HP:0002209)1.62237274
147Bladder neoplasm (HP:0009725)1.61743953
148Bladder carcinoma (HP:0002862)1.61743953
149Biconcave vertebral bodies (HP:0004586)1.61709276
150Choanal atresia (HP:0000453)1.60975079
151Thick eyebrow (HP:0000574)1.59906347
152Broad phalanges of the hand (HP:0009768)1.59068851
15311 pairs of ribs (HP:0000878)1.58997752
154Transitional cell carcinoma of the bladder (HP:0006740)1.58795422
155Centrally nucleated skeletal muscle fibers (HP:0003687)1.58726130
156Broad toe (HP:0001837)1.58161683
157Sudden death (HP:0001699)1.57055394
158Atresia of the external auditory canal (HP:0000413)1.57028234
159Limited hip movement (HP:0008800)1.56874490
160Dilatation of the ascending aorta (HP:0005111)1.56583531
161Abnormality of the lacrimal duct (HP:0011481)1.56411217
162Right ventricular cardiomyopathy (HP:0011663)1.55370273
163Pointed chin (HP:0000307)1.55230167
164Asymmetry of the thorax (HP:0001555)1.55107816
165Embryonal neoplasm (HP:0002898)1.54499610
166Pulmonary artery stenosis (HP:0004415)1.54451643
167Dysmetric saccades (HP:0000641)1.54071693
168Persistence of primary teeth (HP:0006335)1.53670577
169Spondylolisthesis (HP:0003302)1.53617570
170Ureteral stenosis (HP:0000071)1.53411368
171Abnormality of the right ventricle (HP:0001707)1.53341324
172Cafe-au-lait spot (HP:0000957)1.53149761
173Long palpebral fissure (HP:0000637)1.52260742
174Exostoses (HP:0100777)1.51634269
175Midface retrusion (HP:0011800)1.50325234
176Pelvic girdle muscle weakness (HP:0003749)1.49827906
177Patellar dislocation (HP:0002999)1.49768332
178Abnormality of the umbilical cord (HP:0010881)1.49122983
179Glossoptosis (HP:0000162)1.49121424
180Abnormality of the gastric mucosa (HP:0004295)1.48672310
181Rhabdomyosarcoma (HP:0002859)1.48394316
182Deep palmar crease (HP:0006191)1.47666963
183Septate vagina (HP:0001153)1.46729061

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.42543668
2DMPK3.40366875
3SMG13.31157457
4TTK3.24317592
5LATS13.20063262
6BUB12.96352891
7CAMK1G2.88494368
8SRPK12.81192442
9TSSK62.73537794
10CAMK1D2.60103778
11TTN2.58068349
12PBK2.33854210
13EPHA32.33242317
14NEK12.29538379
15SIK11.80992340
16EIF2AK11.78078867
17RIPK41.75383526
18RIPK11.74052262
19FGFR21.73581557
20MTOR1.67523759
21SIK21.65247510
22MAP3K101.64925708
23VRK21.63515838
24BRD41.63049779
25CDK71.59753400
26ICK1.52490118
27TRIB31.50481925
28TAF11.48718382
29STK31.48511575
30CHEK21.47032483
31PLK31.42446299
32STK101.38990374
33PDGFRB1.38931439
34CDK81.38836685
35WEE11.36557101
36MKNK11.34415658
37BRSK11.32105044
38ATR1.31055194
39PLK11.28067244
40FGFR31.27135440
41PDGFRA1.25496135
42CHEK11.24370465
43CDK61.24037678
44MAP3K81.22502109
45RPS6KB21.22072157
46PTK61.21253006
47PNCK1.21014091
48AURKB1.20912676
49PKN21.19821838
50NUAK11.19687967
51EPHB21.18559458
52PTK21.17809871
53NME21.15567055
54EPHB11.12168324
55NTRK31.11907830
56FGFR11.09505039
57BRSK21.08069986
58STK41.06741353
59PLK41.03390215
60TAOK11.02592536
61MKNK21.00886909
62KSR11.00076799
63CDC70.98273041
64RET0.97686295
65BMX0.97489817
66EPHA20.97317345
67AURKA0.96613160
68BRAF0.94022459
69MST1R0.92831759
70JAK10.92211697
71TLK10.92118902
72LRRK20.91872315
73MAP3K40.89600596
74PRPF4B0.88970977
75MARK20.87160990
76ERBB20.87044822
77CDK90.86885415
78LATS20.83528021
79MAP3K90.82713248
80SGK30.82357805
81CLK10.82273663
82EIF2AK30.82093532
83CDK20.81841088
84CDK10.78712191
85MAP3K20.78500695
86MELK0.78405862
87ERBB40.77140193
88EEF2K0.76953838
89ROCK10.75533663
90PAK20.75078747
91ERN10.73730264
92PTK2B0.72861610
93SGK10.72574548
94VRK10.71945820
95PASK0.71839797
96MAPK100.70975769
97RPS6KA40.70814612
98NME10.70482349
99RAF10.69916740
100IRAK20.68916811
101HCK0.66428309
102PLK20.66327763
103FER0.65708507
104FGFR40.64993859
105MAP3K130.64528659
106SIK30.64186526
107CAMK40.63816182
108INSRR0.63418429
109NTRK20.62916403
110MAP3K70.62643650
111DDR20.62263753
112NTRK10.62153168
113NEK20.61868867
114KSR20.61576122
115ZAK0.61466354
116AKT20.61160416
117MARK30.60815784
118PRKD30.58498307
119PIK3CA0.58233965
120HIPK20.57873644
121EIF2AK20.57221555
122ARAF0.56763498
123STK110.55665770
124CDK40.54895110
125LMTK20.54826380
126ATM0.54697298
127IRAK30.54275454
128WNK10.53878506
129ALK0.53709253
130CSNK1E0.52620882
131EGFR0.52615557
132PRKDC0.51393038
133PRKD10.51110062
134CDC42BPA0.50761618
135PAK60.49641395
136MAPK140.49547476
137PAK40.49446273
138MAP4K10.48644453
139ITK0.47914802
140SCYL20.47679164
141ROCK20.46831842
142MAPK80.46461684
143FYN0.46327692
144PRKCQ0.45277326
145CHUK0.45200517
146MET0.44661729
147FRK0.44516682
148ILK0.43453026
149CDK11A0.42986546
150CDK150.42925642
151CSNK2A20.40564455
152CDK30.40545471
153CDK180.39959807
154NEK90.38766977
155PDK20.36905513
156NEK60.34441718

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.25703251
2* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.01203169
3Mismatch repair_Homo sapiens_hsa034302.96175950
4Cell cycle_Homo sapiens_hsa041102.73580324
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.60309024
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59759630
7Spliceosome_Homo sapiens_hsa030402.39935283
8Non-homologous end-joining_Homo sapiens_hsa034502.38526339
9Biosynthesis of amino acids_Homo sapiens_hsa012302.36000040
10RNA transport_Homo sapiens_hsa030132.28073659
11Base excision repair_Homo sapiens_hsa034102.21077619
12Nucleotide excision repair_Homo sapiens_hsa034202.20759680
13One carbon pool by folate_Homo sapiens_hsa006702.09258377
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.04050595
15Dorso-ventral axis formation_Homo sapiens_hsa043201.90589993
16Pyruvate metabolism_Homo sapiens_hsa006201.81604153
17mRNA surveillance pathway_Homo sapiens_hsa030151.76598989
18Carbon metabolism_Homo sapiens_hsa012001.74520907
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.70971703
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.60057099
21MicroRNAs in cancer_Homo sapiens_hsa052061.56983601
22Systemic lupus erythematosus_Homo sapiens_hsa053221.54389108
23Adherens junction_Homo sapiens_hsa045201.52269812
24RNA polymerase_Homo sapiens_hsa030201.51725247
25Dilated cardiomyopathy_Homo sapiens_hsa054141.51109130
26Vitamin B6 metabolism_Homo sapiens_hsa007501.49103753
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46738515
28Thyroid cancer_Homo sapiens_hsa052161.43893612
29Steroid biosynthesis_Homo sapiens_hsa001001.39296442
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.38972922
31Thyroid hormone signaling pathway_Homo sapiens_hsa049191.38966755
32Proteoglycans in cancer_Homo sapiens_hsa052051.38548783
33Type II diabetes mellitus_Homo sapiens_hsa049301.37983607
34Pyrimidine metabolism_Homo sapiens_hsa002401.35419729
35Pentose phosphate pathway_Homo sapiens_hsa000301.33572253
36Glioma_Homo sapiens_hsa052141.31757852
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31106312
38ECM-receptor interaction_Homo sapiens_hsa045121.30829590
39Ribosome_Homo sapiens_hsa030101.30759501
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30629240
41Chronic myeloid leukemia_Homo sapiens_hsa052201.29808147
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29574777
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28472612
44Long-term potentiation_Homo sapiens_hsa047201.27801535
45Lysine degradation_Homo sapiens_hsa003101.27725617
46Fanconi anemia pathway_Homo sapiens_hsa034601.27011230
47Focal adhesion_Homo sapiens_hsa045101.26072492
48Homologous recombination_Homo sapiens_hsa034401.25427491
49Basal cell carcinoma_Homo sapiens_hsa052171.23094331
50Small cell lung cancer_Homo sapiens_hsa052221.21708768
51mTOR signaling pathway_Homo sapiens_hsa041501.20832083
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20341648
53Viral myocarditis_Homo sapiens_hsa054161.17780650
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.16112116
55Alcoholism_Homo sapiens_hsa050341.16093195
56Estrogen signaling pathway_Homo sapiens_hsa049151.15652437
57Axon guidance_Homo sapiens_hsa043601.14318653
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13503458
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11300157
60Basal transcription factors_Homo sapiens_hsa030221.11265029
61VEGF signaling pathway_Homo sapiens_hsa043701.10804246
62Renal cell carcinoma_Homo sapiens_hsa052111.09386395
63Osteoclast differentiation_Homo sapiens_hsa043801.08521209
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07998727
65Melanogenesis_Homo sapiens_hsa049161.06938962
66Renin secretion_Homo sapiens_hsa049241.06589116
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06108275
68Wnt signaling pathway_Homo sapiens_hsa043101.04670731
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04158253
70Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04121830
71Pancreatic cancer_Homo sapiens_hsa052121.04095257
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03653389
73Salivary secretion_Homo sapiens_hsa049701.03650075
74cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03646818
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03263828
76Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02449293
77Selenocompound metabolism_Homo sapiens_hsa004501.02083999
78T cell receptor signaling pathway_Homo sapiens_hsa046601.01919583
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01057312
80Sulfur relay system_Homo sapiens_hsa041221.00423825
81Notch signaling pathway_Homo sapiens_hsa043301.00098529
82Colorectal cancer_Homo sapiens_hsa052100.99361921
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98633372
84Viral carcinogenesis_Homo sapiens_hsa052030.97919261
85Rap1 signaling pathway_Homo sapiens_hsa040150.97025865
86TGF-beta signaling pathway_Homo sapiens_hsa043500.96938218
87Hedgehog signaling pathway_Homo sapiens_hsa043400.95392399
88RNA degradation_Homo sapiens_hsa030180.94476387
89Folate biosynthesis_Homo sapiens_hsa007900.94242969
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93710501
91Amoebiasis_Homo sapiens_hsa051460.93399294
92ErbB signaling pathway_Homo sapiens_hsa040120.92808391
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.92612849
94Gastric acid secretion_Homo sapiens_hsa049710.92238185
95Prostate cancer_Homo sapiens_hsa052150.92233493
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92076876
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91719660
98Platelet activation_Homo sapiens_hsa046110.91372632
99Oxytocin signaling pathway_Homo sapiens_hsa049210.91236580
100Non-small cell lung cancer_Homo sapiens_hsa052230.91029805
101cAMP signaling pathway_Homo sapiens_hsa040240.90953069
102Endometrial cancer_Homo sapiens_hsa052130.90793814
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89464446
104Oocyte meiosis_Homo sapiens_hsa041140.89455914
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89233392
106Hippo signaling pathway_Homo sapiens_hsa043900.88750581
107Toxoplasmosis_Homo sapiens_hsa051450.87461202
108B cell receptor signaling pathway_Homo sapiens_hsa046620.87173017
109HTLV-I infection_Homo sapiens_hsa051660.87116661
110GnRH signaling pathway_Homo sapiens_hsa049120.86696140
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85563919
112Hepatitis B_Homo sapiens_hsa051610.85339645
113MAPK signaling pathway_Homo sapiens_hsa040100.85143716
114Melanoma_Homo sapiens_hsa052180.83872247
115Circadian entrainment_Homo sapiens_hsa047130.83652785
116Pathways in cancer_Homo sapiens_hsa052000.83645715
117Amphetamine addiction_Homo sapiens_hsa050310.81730674
118TNF signaling pathway_Homo sapiens_hsa046680.81716607
119Insulin secretion_Homo sapiens_hsa049110.81625553
120Insulin resistance_Homo sapiens_hsa049310.81483358
121p53 signaling pathway_Homo sapiens_hsa041150.80235673
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.78090522
123N-Glycan biosynthesis_Homo sapiens_hsa005100.77814676
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.77634292
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77529326
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77113477
127Choline metabolism in cancer_Homo sapiens_hsa052310.75993533
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75984687
129Arginine biosynthesis_Homo sapiens_hsa002200.75808730
130Gap junction_Homo sapiens_hsa045400.75748791
131Purine metabolism_Homo sapiens_hsa002300.75225264
132Arginine and proline metabolism_Homo sapiens_hsa003300.75162622
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74658360
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74218690
135Proteasome_Homo sapiens_hsa030500.73193431
136Leishmaniasis_Homo sapiens_hsa051400.71239360
137Cholinergic synapse_Homo sapiens_hsa047250.70681053
138Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70103171
139Long-term depression_Homo sapiens_hsa047300.69937030
140Acute myeloid leukemia_Homo sapiens_hsa052210.69127742
141Dopaminergic synapse_Homo sapiens_hsa047280.68814503
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68682626
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.67723543
144Fructose and mannose metabolism_Homo sapiens_hsa000510.66908620
145Glucagon signaling pathway_Homo sapiens_hsa049220.66694690
146NF-kappa B signaling pathway_Homo sapiens_hsa040640.66688602
147FoxO signaling pathway_Homo sapiens_hsa040680.66220927
148African trypanosomiasis_Homo sapiens_hsa051430.65744920
149Galactose metabolism_Homo sapiens_hsa000520.65658906
150Bladder cancer_Homo sapiens_hsa052190.65594064
151Inositol phosphate metabolism_Homo sapiens_hsa005620.65212898
152Tight junction_Homo sapiens_hsa045300.61646561
153Fatty acid elongation_Homo sapiens_hsa000620.60679132
154Cyanoamino acid metabolism_Homo sapiens_hsa004600.60379758
155Fatty acid metabolism_Homo sapiens_hsa012120.59066219
156Fatty acid biosynthesis_Homo sapiens_hsa000610.51824716
157AMPK signaling pathway_Homo sapiens_hsa041520.49275991
158Insulin signaling pathway_Homo sapiens_hsa049100.46942145
159Propanoate metabolism_Homo sapiens_hsa006400.42542547
160Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39653114
161Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34156169
162Epstein-Barr virus infection_Homo sapiens_hsa051690.33401365
163Prion diseases_Homo sapiens_hsa050200.29497731
164Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25925477

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