

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nucleobase biosynthetic process (GO:0046112) | 4.93933202 |
| 2 | purine nucleobase biosynthetic process (GO:0009113) | 4.76841164 |
| 3 | ribosome biogenesis (GO:0042254) | 4.71541715 |
| 4 | IMP biosynthetic process (GO:0006188) | 4.70966234 |
| 5 | ribosome assembly (GO:0042255) | 4.63129619 |
| 6 | formation of translation preinitiation complex (GO:0001731) | 4.45312115 |
| 7 | nuclear pore organization (GO:0006999) | 4.41864313 |
| 8 | mitotic metaphase plate congression (GO:0007080) | 4.40500569 |
| 9 | nuclear pore complex assembly (GO:0051292) | 4.11511758 |
| 10 | mitotic sister chromatid segregation (GO:0000070) | 4.08638642 |
| 11 | protein localization to kinetochore (GO:0034501) | 4.08186355 |
| 12 | telomere maintenance via recombination (GO:0000722) | 4.04084714 |
| 13 | mitotic nuclear envelope disassembly (GO:0007077) | 3.97747557 |
| 14 | DNA unwinding involved in DNA replication (GO:0006268) | 3.92314900 |
| 15 | IMP metabolic process (GO:0046040) | 3.91932820 |
| 16 | mitotic recombination (GO:0006312) | 3.89119171 |
| 17 | DNA replication initiation (GO:0006270) | 3.81154040 |
| 18 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.80473043 |
| 19 | establishment of viral latency (GO:0019043) | 3.78107927 |
| 20 | nuclear envelope disassembly (GO:0051081) | 3.72948351 |
| 21 | membrane disassembly (GO:0030397) | 3.72948351 |
| 22 | regulation of gene silencing by miRNA (GO:0060964) | 3.72851084 |
| 23 | regulation of gene silencing by RNA (GO:0060966) | 3.72851084 |
| 24 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.72851084 |
| 25 | sister chromatid segregation (GO:0000819) | 3.68187739 |
| 26 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.66028743 |
| 27 | DNA topological change (GO:0006265) | 3.64170363 |
| 28 | metaphase plate congression (GO:0051310) | 3.60171245 |
| 29 | histone arginine methylation (GO:0034969) | 3.59852023 |
| 30 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.55617475 |
| 31 | maturation of SSU-rRNA (GO:0030490) | 3.55445645 |
| 32 | non-recombinational repair (GO:0000726) | 3.53098989 |
| 33 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.53098989 |
| 34 | negative regulation of mRNA processing (GO:0050686) | 3.52690805 |
| 35 | pre-miRNA processing (GO:0031054) | 3.52454429 |
| 36 | DNA replication checkpoint (GO:0000076) | 3.51663894 |
| 37 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.50736413 |
| 38 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.50306900 |
| 39 | DNA geometric change (GO:0032392) | 3.48192184 |
| 40 | DNA duplex unwinding (GO:0032508) | 3.48190075 |
| 41 | regulation of translational fidelity (GO:0006450) | 3.47765260 |
| 42 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.47407985 |
| 43 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.47407985 |
| 44 | proteasome assembly (GO:0043248) | 3.47115610 |
| 45 | DNA ligation (GO:0006266) | 3.45220967 |
| 46 | protein complex localization (GO:0031503) | 3.40838922 |
| 47 | regulation of translational termination (GO:0006449) | 3.38998366 |
| 48 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.35671057 |
| 49 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.34287315 |
| 50 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.33679231 |
| 51 | L-serine metabolic process (GO:0006563) | 3.33258653 |
| 52 | mitotic chromosome condensation (GO:0007076) | 3.29057704 |
| 53 | cullin deneddylation (GO:0010388) | 3.29024617 |
| 54 | DNA strand elongation (GO:0022616) | 3.28537151 |
| 55 | regulation of helicase activity (GO:0051095) | 3.27304738 |
| 56 | peptidyl-arginine methylation (GO:0018216) | 3.26856764 |
| 57 | peptidyl-arginine N-methylation (GO:0035246) | 3.26856764 |
| 58 | negative regulation of mRNA metabolic process (GO:1903312) | 3.26837522 |
| 59 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.26817920 |
| 60 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.26759172 |
| 61 | regulation of spindle organization (GO:0090224) | 3.26019859 |
| 62 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.25846545 |
| 63 | chromatin remodeling at centromere (GO:0031055) | 3.25731406 |
| 64 | CENP-A containing nucleosome assembly (GO:0034080) | 3.24474603 |
| 65 | folic acid metabolic process (GO:0046655) | 3.21267825 |
| 66 | spliceosomal snRNP assembly (GO:0000387) | 3.19919916 |
| 67 | tRNA aminoacylation for protein translation (GO:0006418) | 3.19466753 |
| 68 | base-excision repair (GO:0006284) | 3.18012656 |
| 69 | mitotic sister chromatid cohesion (GO:0007064) | 3.17860030 |
| 70 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.16361602 |
| 71 | amino acid activation (GO:0043038) | 3.15739832 |
| 72 | tRNA aminoacylation (GO:0043039) | 3.15739832 |
| 73 | establishment of chromosome localization (GO:0051303) | 3.14368295 |
| 74 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.13772830 |
| 75 | negative regulation of ligase activity (GO:0051352) | 3.13772830 |
| 76 | heterochromatin organization (GO:0070828) | 3.13679735 |
| 77 | * rRNA processing (GO:0006364) | 3.12323462 |
| 78 | negative regulation of RNA splicing (GO:0033119) | 3.11995589 |
| 79 | RNA splicing, via transesterification reactions (GO:0000375) | 3.11453501 |
| 80 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.10805297 |
| 81 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 3.09944057 |
| 82 | mRNA splicing, via spliceosome (GO:0000398) | 3.09944057 |
| 83 | regulation of mitochondrial translation (GO:0070129) | 3.08505018 |
| 84 | ribosomal large subunit biogenesis (GO:0042273) | 3.08039428 |
| 85 | negative regulation of chromosome segregation (GO:0051985) | 3.07623210 |
| 86 | pore complex assembly (GO:0046931) | 3.06638338 |
| 87 | regulation of centrosome cycle (GO:0046605) | 3.06382609 |
| 88 | histone H2A acetylation (GO:0043968) | 3.04461705 |
| 89 | pseudouridine synthesis (GO:0001522) | 3.04043056 |
| 90 | * rRNA metabolic process (GO:0016072) | 3.03535347 |
| 91 | protein localization to chromosome, centromeric region (GO:0071459) | 3.02532859 |
| 92 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.02285999 |
| 93 | DNA replication-independent nucleosome organization (GO:0034724) | 3.02285999 |
| 94 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.01967807 |
| 95 | histone H4-K12 acetylation (GO:0043983) | 3.01347129 |
| 96 | viral mRNA export from host cell nucleus (GO:0046784) | 3.00673418 |
| 97 | rRNA modification (GO:0000154) | 3.00441797 |
| 98 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.99690469 |
| 99 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.99690469 |
| 100 | negative regulation of sister chromatid segregation (GO:0033046) | 2.99690469 |
| 101 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.99690469 |
| 102 | positive regulation of chromosome segregation (GO:0051984) | 2.98904910 |
| 103 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.98630374 |
| 104 | mRNA transport (GO:0051028) | 2.97650885 |
| 105 | spindle checkpoint (GO:0031577) | 2.97304582 |
| 106 | maturation of 5.8S rRNA (GO:0000460) | 2.96911047 |
| 107 | DNA synthesis involved in DNA repair (GO:0000731) | 2.96781192 |
| 108 | mitotic spindle assembly checkpoint (GO:0007094) | 2.96431203 |
| 109 | spliceosomal complex assembly (GO:0000245) | 2.96409732 |
| 110 | ATP-dependent chromatin remodeling (GO:0043044) | 2.95365658 |
| 111 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.95295872 |
| 112 | spindle assembly checkpoint (GO:0071173) | 2.95220080 |
| 113 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.95008294 |
| 114 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.95008294 |
| 115 | chromosome segregation (GO:0007059) | 2.94870053 |
| 116 | protein deneddylation (GO:0000338) | 2.94511046 |
| 117 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.92220368 |
| 118 | negative regulation of histone methylation (GO:0031061) | 2.91762908 |
| 119 | mitotic spindle checkpoint (GO:0071174) | 2.90638151 |
| 120 | histone H2A monoubiquitination (GO:0035518) | 2.90568701 |
| 121 | regulation of mitotic spindle organization (GO:0060236) | 2.90497317 |
| 122 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.89335838 |
| 123 | RNA export from nucleus (GO:0006405) | 2.89196097 |
| 124 | paraxial mesoderm development (GO:0048339) | 2.88782064 |
| 125 | chaperone-mediated protein complex assembly (GO:0051131) | 2.87922070 |
| 126 | mRNA export from nucleus (GO:0006406) | 2.87206193 |
| 127 | telomere maintenance via telomere lengthening (GO:0010833) | 2.85734457 |
| 128 | trophectodermal cell differentiation (GO:0001829) | 2.84370771 |
| 129 | establishment of integrated proviral latency (GO:0075713) | 2.82473073 |
| 130 | kinetochore organization (GO:0051383) | 2.82413739 |
| 131 | nuclear envelope organization (GO:0006998) | 2.80908807 |
| 132 | regulation of chromosome segregation (GO:0051983) | 2.77930074 |
| 133 | termination of RNA polymerase I transcription (GO:0006363) | 2.77515337 |
| 134 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.77357858 |
| 135 | DNA conformation change (GO:0071103) | 2.77341028 |
| 136 | termination of RNA polymerase II transcription (GO:0006369) | 2.76466332 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.56912346 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.59003329 |
| 3 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.59949676 |
| 4 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.48369421 |
| 5 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.41887122 |
| 6 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.25314799 |
| 7 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 3.01588562 |
| 8 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.92810917 |
| 9 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.90195644 |
| 10 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.85786373 |
| 11 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.85474985 |
| 12 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.83204371 |
| 13 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.73227272 |
| 14 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.64268305 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.58120808 |
| 16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.56198561 |
| 17 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.54154972 |
| 18 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.36629523 |
| 19 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.32073649 |
| 20 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 2.29506048 |
| 21 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 2.28837155 |
| 22 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.24793043 |
| 23 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.22344703 |
| 24 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.15870693 |
| 25 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.14968853 |
| 26 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 2.09666419 |
| 27 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.08802991 |
| 28 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 2.07974462 |
| 29 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 2.07898355 |
| 30 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.04619848 |
| 31 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.90618398 |
| 32 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.90083017 |
| 33 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.87776293 |
| 34 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.86532005 |
| 35 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.85715791 |
| 36 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.84485983 |
| 37 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.82013712 |
| 38 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.81404787 |
| 39 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.80719600 |
| 40 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.77625593 |
| 41 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.72581901 |
| 42 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.72137898 |
| 43 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.72019712 |
| 44 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.65804252 |
| 45 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.65791954 |
| 46 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.65505138 |
| 47 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.65252970 |
| 48 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.65215299 |
| 49 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.61599746 |
| 50 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.61171890 |
| 51 | MYC_22102868_ChIP-Seq_BL_Human | 1.59726713 |
| 52 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.57589352 |
| 53 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.56491838 |
| 54 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.53984295 |
| 55 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.53775918 |
| 56 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.52833454 |
| 57 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.49320218 |
| 58 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.49320218 |
| 59 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.49320218 |
| 60 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.42980791 |
| 61 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.42969378 |
| 62 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.42393752 |
| 63 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.39739363 |
| 64 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.37350855 |
| 65 | * PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.33793225 |
| 66 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.33046503 |
| 67 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.32222619 |
| 68 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.31437682 |
| 69 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.31240904 |
| 70 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.30125611 |
| 71 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.28767123 |
| 72 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.27986848 |
| 73 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 1.27415902 |
| 74 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 1.26575275 |
| 75 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.26133178 |
| 76 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.23682497 |
| 77 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.22745332 |
| 78 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.22432137 |
| 79 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.20506775 |
| 80 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.20279831 |
| 81 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.20257950 |
| 82 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.20031603 |
| 83 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.19945924 |
| 84 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.18428455 |
| 85 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.16316928 |
| 86 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.16157748 |
| 87 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 1.16129810 |
| 88 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.11345772 |
| 89 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.10820071 |
| 90 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.10311297 |
| 91 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.09536299 |
| 92 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.09078247 |
| 93 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.08968932 |
| 94 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 1.08621195 |
| 95 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.07992972 |
| 96 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.05660488 |
| 97 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.05572020 |
| 98 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.04676556 |
| 99 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.04596829 |
| 100 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.03551136 |
| 101 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.03392337 |
| 102 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.03131303 |
| 103 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 1.01644428 |
| 104 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.01049842 |
| 105 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.00466139 |
| 106 | POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 0.99276232 |
| 107 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.96757491 |
| 108 | SOX2_18692474_ChIP-Seq_MESCs_Mouse | 0.94104728 |
| 109 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.93272359 |
| 110 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.93029391 |
| 111 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92661198 |
| 112 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.91401674 |
| 113 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 0.90733756 |
| 114 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.90539265 |
| 115 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.89430979 |
| 116 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.88580045 |
| 117 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.88562434 |
| 118 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.86717282 |
| 119 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.86074118 |
| 120 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.85299085 |
| 121 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.84703168 |
| 122 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.83259744 |
| 123 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.83254895 |
| 124 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.83243462 |
| 125 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.82708292 |
| 126 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.81757540 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.97590129 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.41088534 |
| 3 | MP0003111_abnormal_nucleus_morphology | 4.08578974 |
| 4 | MP0010094_abnormal_chromosome_stability | 4.08026128 |
| 5 | MP0003077_abnormal_cell_cycle | 3.60223343 |
| 6 | MP0003123_paternal_imprinting | 3.27857276 |
| 7 | MP0008057_abnormal_DNA_replication | 2.99835548 |
| 8 | MP0008058_abnormal_DNA_repair | 2.91384023 |
| 9 | MP0001730_embryonic_growth_arrest | 2.59913696 |
| 10 | MP0008877_abnormal_DNA_methylation | 2.54194764 |
| 11 | MP0003121_genomic_imprinting | 2.47002582 |
| 12 | MP0008007_abnormal_cellular_replicative | 2.42191181 |
| 13 | MP0005380_embryogenesis_phenotype | 2.23251787 |
| 14 | MP0001672_abnormal_embryogenesis/_devel | 2.23251787 |
| 15 | MP0010352_gastrointestinal_tract_polyps | 2.21372092 |
| 16 | MP0000350_abnormal_cell_proliferation | 2.20872051 |
| 17 | MP0008932_abnormal_embryonic_tissue | 2.16543689 |
| 18 | MP0003984_embryonic_growth_retardation | 2.09745385 |
| 19 | MP0004264_abnormal_extraembryonic_tissu | 2.09659691 |
| 20 | MP0004133_heterotaxia | 2.07545238 |
| 21 | MP0003787_abnormal_imprinting | 2.06794636 |
| 22 | MP0002088_abnormal_embryonic_growth/wei | 2.04048648 |
| 23 | MP0003890_abnormal_embryonic-extraembry | 1.92770468 |
| 24 | MP0003786_premature_aging | 1.92330350 |
| 25 | MP0001697_abnormal_embryo_size | 1.89781377 |
| 26 | MP0002084_abnormal_developmental_patter | 1.85797957 |
| 27 | MP0003119_abnormal_digestive_system | 1.83545617 |
| 28 | MP0010030_abnormal_orbit_morphology | 1.79674056 |
| 29 | MP0003806_abnormal_nucleotide_metabolis | 1.77537729 |
| 30 | MP0002086_abnormal_extraembryonic_tissu | 1.77458463 |
| 31 | MP0002085_abnormal_embryonic_tissue | 1.73097844 |
| 32 | MP0002080_prenatal_lethality | 1.72804061 |
| 33 | MP0004197_abnormal_fetal_growth/weight/ | 1.69115992 |
| 34 | MP0003122_maternal_imprinting | 1.64939692 |
| 35 | MP0002877_abnormal_melanocyte_morpholog | 1.62435249 |
| 36 | MP0002653_abnormal_ependyma_morphology | 1.61423271 |
| 37 | MP0003941_abnormal_skin_development | 1.57032598 |
| 38 | MP0003718_maternal_effect | 1.50161642 |
| 39 | MP0004233_abnormal_muscle_weight | 1.48503283 |
| 40 | MP0006292_abnormal_olfactory_placode | 1.45355149 |
| 41 | MP0004084_abnormal_cardiac_muscle | 1.44734188 |
| 42 | MP0003567_abnormal_fetal_cardiomyocyte | 1.43785519 |
| 43 | MP0008260_abnormal_autophagy | 1.31613739 |
| 44 | MP0002269_muscular_atrophy | 1.28166221 |
| 45 | MP0002396_abnormal_hematopoietic_system | 1.27846796 |
| 46 | MP0000750_abnormal_muscle_regeneration | 1.25045883 |
| 47 | MP0006072_abnormal_retinal_apoptosis | 1.24386823 |
| 48 | MP0005451_abnormal_body_composition | 1.21951543 |
| 49 | MP0004185_abnormal_adipocyte_glucose | 1.14160012 |
| 50 | MP0002127_abnormal_cardiovascular_syste | 1.11744866 |
| 51 | MP0000313_abnormal_cell_death | 1.10483422 |
| 52 | MP0001346_abnormal_lacrimal_gland | 1.09859151 |
| 53 | MP0001661_extended_life_span | 1.08829078 |
| 54 | MP0003315_abnormal_perineum_morphology | 1.08621701 |
| 55 | MP0001293_anophthalmia | 1.07023175 |
| 56 | MP0010307_abnormal_tumor_latency | 1.06921836 |
| 57 | MP0005501_abnormal_skin_physiology | 1.06724993 |
| 58 | MP0009672_abnormal_birth_weight | 1.06549845 |
| 59 | MP0004808_abnormal_hematopoietic_stem | 1.05892625 |
| 60 | MP0005266_abnormal_metabolism | 1.05047436 |
| 61 | MP0002160_abnormal_reproductive_system | 1.04536000 |
| 62 | MP0003566_abnormal_cell_adhesion | 1.04439607 |
| 63 | MP0003221_abnormal_cardiomyocyte_apopto | 1.03805180 |
| 64 | MP0000537_abnormal_urethra_morphology | 1.01657839 |
| 65 | MP0005076_abnormal_cell_differentiation | 1.01444461 |
| 66 | MP0003705_abnormal_hypodermis_morpholog | 1.00932784 |
| 67 | MP0001929_abnormal_gametogenesis | 0.99025903 |
| 68 | MP0006035_abnormal_mitochondrial_morpho | 0.94967440 |
| 69 | MP0003186_abnormal_redox_activity | 0.94654567 |
| 70 | MP0000678_abnormal_parathyroid_gland | 0.94174188 |
| 71 | MP0005187_abnormal_penis_morphology | 0.93359846 |
| 72 | MP0002163_abnormal_gland_morphology | 0.92213451 |
| 73 | MP0005394_taste/olfaction_phenotype | 0.90259081 |
| 74 | MP0005499_abnormal_olfactory_system | 0.90259081 |
| 75 | MP0002019_abnormal_tumor_incidence | 0.89813230 |
| 76 | MP0005384_cellular_phenotype | 0.86763217 |
| 77 | MP0000358_abnormal_cell_content/ | 0.86578070 |
| 78 | MP0001727_abnormal_embryo_implantation | 0.85224270 |
| 79 | MP0009053_abnormal_anal_canal | 0.83110440 |
| 80 | MP0001853_heart_inflammation | 0.82942173 |
| 81 | MP0002210_abnormal_sex_determination | 0.82774037 |
| 82 | MP0002697_abnormal_eye_size | 0.82626408 |
| 83 | MP0009697_abnormal_copulation | 0.82200828 |
| 84 | MP0009703_decreased_birth_body | 0.82185913 |
| 85 | MP0001849_ear_inflammation | 0.82025451 |
| 86 | MP0006036_abnormal_mitochondrial_physio | 0.81570280 |
| 87 | MP0000579_abnormal_nail_morphology | 0.80102540 |
| 88 | MP0001145_abnormal_male_reproductive | 0.78858309 |
| 89 | MP0008789_abnormal_olfactory_epithelium | 0.76546029 |
| 90 | MP0009278_abnormal_bone_marrow | 0.75810929 |
| 91 | MP0002796_impaired_skin_barrier | 0.75810379 |
| 92 | MP0000490_abnormal_crypts_of | 0.75772475 |
| 93 | MP0003937_abnormal_limbs/digits/tail_de | 0.74790646 |
| 94 | MP0005621_abnormal_cell_physiology | 0.72676321 |
| 95 | MP0005670_abnormal_white_adipose | 0.72646428 |
| 96 | MP0000751_myopathy | 0.72389862 |
| 97 | MP0002111_abnormal_tail_morphology | 0.72358245 |
| 98 | MP0000566_synostosis | 0.71558797 |
| 99 | MP0000703_abnormal_thymus_morphology | 0.71071730 |
| 100 | MP0005389_reproductive_system_phenotype | 0.70798701 |
| 101 | MP0003385_abnormal_body_wall | 0.70305595 |
| 102 | MP0004147_increased_porphyrin_level | 0.69842583 |
| 103 | MP0000653_abnormal_sex_gland | 0.69820872 |
| 104 | MP0008995_early_reproductive_senescence | 0.69627374 |
| 105 | MP0003936_abnormal_reproductive_system | 0.69407337 |
| 106 | MP0002161_abnormal_fertility/fecundity | 0.68477126 |
| 107 | MP0005623_abnormal_meninges_morphology | 0.67481369 |
| 108 | MP0003698_abnormal_male_reproductive | 0.66079528 |
| 109 | MP0003861_abnormal_nervous_system | 0.65105034 |
| 110 | MP0005023_abnormal_wound_healing | 0.64920374 |
| 111 | MP0008775_abnormal_heart_ventricle | 0.64704575 |
| 112 | MP0002249_abnormal_larynx_morphology | 0.64075921 |
| 113 | MP0000266_abnormal_heart_morphology | 0.62945696 |
| 114 | MP0005330_cardiomyopathy | 0.62939961 |
| 115 | MP0003115_abnormal_respiratory_system | 0.62652181 |
| 116 | MP0003755_abnormal_palate_morphology | 0.62060331 |
| 117 | MP0004087_abnormal_muscle_fiber | 0.61811242 |
| 118 | MP0002970_abnormal_white_adipose | 0.61785528 |
| 119 | MP0001286_abnormal_eye_development | 0.61085541 |
| 120 | MP0003950_abnormal_plasma_membrane | 0.60950722 |
| 121 | MP0001119_abnormal_female_reproductive | 0.60701267 |
| 122 | MP0002332_abnormal_exercise_endurance | 0.60093319 |
| 123 | MP0008770_decreased_survivor_rate | 0.59832251 |
| 124 | MP0000428_abnormal_craniofacial_morphol | 0.59102305 |
| 125 | MP0003699_abnormal_female_reproductive | 0.58752193 |
| 126 | MP0003935_abnormal_craniofacial_develop | 0.58123785 |
| 127 | MP0001915_intracranial_hemorrhage | 0.57905069 |
| 128 | MP0010630_abnormal_cardiac_muscle | 0.57762689 |
| 129 | MP0005551_abnormal_eye_electrophysiolog | 0.56923372 |
| 130 | MP0010234_abnormal_vibrissa_follicle | 0.55754034 |
| 131 | MP0001188_hyperpigmentation | 0.54806417 |
| 132 | MP0001881_abnormal_mammary_gland | 0.52344505 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of the labia minora (HP:0012880) | 4.75361720 |
| 2 | Ependymoma (HP:0002888) | 4.39543931 |
| 3 | Microvesicular hepatic steatosis (HP:0001414) | 4.05990036 |
| 4 | Birth length less than 3rd percentile (HP:0003561) | 3.92272066 |
| 5 | Selective tooth agenesis (HP:0001592) | 3.45834675 |
| 6 | Progressive muscle weakness (HP:0003323) | 3.41536360 |
| 7 | Oral leukoplakia (HP:0002745) | 3.38961830 |
| 8 | Abnormal gallbladder physiology (HP:0012438) | 3.32380314 |
| 9 | Cholecystitis (HP:0001082) | 3.32380314 |
| 10 | Medulloblastoma (HP:0002885) | 3.30553562 |
| 11 | Breast hypoplasia (HP:0003187) | 3.25941332 |
| 12 | Astrocytoma (HP:0009592) | 3.12669922 |
| 13 | Abnormality of the astrocytes (HP:0100707) | 3.12669922 |
| 14 | Patellar aplasia (HP:0006443) | 2.94092613 |
| 15 | Multiple enchondromatosis (HP:0005701) | 2.82916014 |
| 16 | Abnormality of the anterior horn cell (HP:0006802) | 2.82092411 |
| 17 | Degeneration of anterior horn cells (HP:0002398) | 2.82092411 |
| 18 | Cerebral hypomyelination (HP:0006808) | 2.79996170 |
| 19 | Reticulocytopenia (HP:0001896) | 2.77793919 |
| 20 | Carpal bone hypoplasia (HP:0001498) | 2.76074533 |
| 21 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.74048972 |
| 22 | Glioma (HP:0009733) | 2.72376716 |
| 23 | Muscle fibrillation (HP:0010546) | 2.71822853 |
| 24 | Abnormality of the lower motor neuron (HP:0002366) | 2.69317179 |
| 25 | Chromsome breakage (HP:0040012) | 2.67363922 |
| 26 | Colon cancer (HP:0003003) | 2.65814387 |
| 27 | Rhabdomyosarcoma (HP:0002859) | 2.59155954 |
| 28 | Absent radius (HP:0003974) | 2.58100726 |
| 29 | Tongue fasciculations (HP:0001308) | 2.53496539 |
| 30 | Abnormal number of incisors (HP:0011064) | 2.52278310 |
| 31 | Spastic diplegia (HP:0001264) | 2.51026085 |
| 32 | Volvulus (HP:0002580) | 2.49151118 |
| 33 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.48136387 |
| 34 | Rough bone trabeculation (HP:0100670) | 2.45328675 |
| 35 | Shawl scrotum (HP:0000049) | 2.44981372 |
| 36 | Absent forearm bone (HP:0003953) | 2.43725919 |
| 37 | Aplasia involving forearm bones (HP:0009822) | 2.43725919 |
| 38 | Supernumerary spleens (HP:0009799) | 2.42212176 |
| 39 | Facial hemangioma (HP:0000329) | 2.39922336 |
| 40 | Progressive external ophthalmoplegia (HP:0000590) | 2.36323081 |
| 41 | Impulsivity (HP:0100710) | 2.34074940 |
| 42 | Secondary amenorrhea (HP:0000869) | 2.32888439 |
| 43 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.31851305 |
| 44 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.29360825 |
| 45 | Deviation of the thumb (HP:0009603) | 2.27080226 |
| 46 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.26941943 |
| 47 | Delayed puberty (HP:0000823) | 2.26868060 |
| 48 | Biliary tract neoplasm (HP:0100574) | 2.25989994 |
| 49 | Cortical dysplasia (HP:0002539) | 2.22442960 |
| 50 | Abnormality of cochlea (HP:0000375) | 2.21693779 |
| 51 | Insomnia (HP:0100785) | 2.20916123 |
| 52 | Proximal placement of thumb (HP:0009623) | 2.20042950 |
| 53 | Neoplasm of striated muscle (HP:0009728) | 2.19816275 |
| 54 | Abnormality of the preputium (HP:0100587) | 2.19584158 |
| 55 | Broad distal phalanx of finger (HP:0009836) | 2.18642153 |
| 56 | Shoulder girdle muscle weakness (HP:0003547) | 2.18043884 |
| 57 | Neoplasm of the pancreas (HP:0002894) | 2.17252394 |
| 58 | Neoplasm of the oral cavity (HP:0100649) | 2.16473340 |
| 59 | Type I transferrin isoform profile (HP:0003642) | 2.15744717 |
| 60 | Meckel diverticulum (HP:0002245) | 2.15434414 |
| 61 | Increased serum pyruvate (HP:0003542) | 2.14895775 |
| 62 | Abnormality of glycolysis (HP:0004366) | 2.14895775 |
| 63 | Hyperacusis (HP:0010780) | 2.13357733 |
| 64 | Abdominal situs inversus (HP:0003363) | 2.12354792 |
| 65 | Abnormality of abdominal situs (HP:0011620) | 2.12354792 |
| 66 | Abnormality of the ileum (HP:0001549) | 2.11757688 |
| 67 | Overriding aorta (HP:0002623) | 2.11747942 |
| 68 | Pendular nystagmus (HP:0012043) | 2.11026275 |
| 69 | Missing ribs (HP:0000921) | 2.09385660 |
| 70 | Abnormality of chromosome stability (HP:0003220) | 2.08103007 |
| 71 | High anterior hairline (HP:0009890) | 2.07986815 |
| 72 | Horseshoe kidney (HP:0000085) | 2.06364662 |
| 73 | Increased serum lactate (HP:0002151) | 2.04724714 |
| 74 | Premature ovarian failure (HP:0008209) | 2.04284879 |
| 75 | Pelvic girdle muscle weakness (HP:0003749) | 2.03401484 |
| 76 | Myelodysplasia (HP:0002863) | 2.02349896 |
| 77 | Congenital stationary night blindness (HP:0007642) | 2.01800100 |
| 78 | Testicular atrophy (HP:0000029) | 2.01361536 |
| 79 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.00909739 |
| 80 | Aplastic anemia (HP:0001915) | 2.00588510 |
| 81 | Squamous cell carcinoma (HP:0002860) | 2.00307428 |
| 82 | Premature graying of hair (HP:0002216) | 1.98640562 |
| 83 | Rib fusion (HP:0000902) | 1.97506729 |
| 84 | Postnatal microcephaly (HP:0005484) | 1.96815852 |
| 85 | Hepatocellular necrosis (HP:0001404) | 1.96758782 |
| 86 | Agnosia (HP:0010524) | 1.96705844 |
| 87 | Embryonal renal neoplasm (HP:0011794) | 1.95866739 |
| 88 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.94340265 |
| 89 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.94340265 |
| 90 | Increased nuchal translucency (HP:0010880) | 1.94282934 |
| 91 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.94211658 |
| 92 | Preauricular skin tag (HP:0000384) | 1.93956239 |
| 93 | Anal stenosis (HP:0002025) | 1.91839814 |
| 94 | Trismus (HP:0000211) | 1.91266596 |
| 95 | Abnormal lung lobation (HP:0002101) | 1.90908479 |
| 96 | Reduced antithrombin III activity (HP:0001976) | 1.89855054 |
| 97 | Abnormality of the labia (HP:0000058) | 1.89521588 |
| 98 | Abnormality of methionine metabolism (HP:0010901) | 1.89345779 |
| 99 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.88158462 |
| 100 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.88158462 |
| 101 | Abnormal protein glycosylation (HP:0012346) | 1.88158462 |
| 102 | Abnormal glycosylation (HP:0012345) | 1.88158462 |
| 103 | Facial cleft (HP:0002006) | 1.87241659 |
| 104 | Breast aplasia (HP:0100783) | 1.86686160 |
| 105 | Choanal atresia (HP:0000453) | 1.86625256 |
| 106 | Cellular immunodeficiency (HP:0005374) | 1.86150077 |
| 107 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.86135307 |
| 108 | Abnormality of reticulocytes (HP:0004312) | 1.85068845 |
| 109 | Urethral obstruction (HP:0000796) | 1.84916645 |
| 110 | Basal cell carcinoma (HP:0002671) | 1.83808942 |
| 111 | Sloping forehead (HP:0000340) | 1.82135356 |
| 112 | Abnormal biliary tract morphology (HP:0012440) | 1.81084134 |
| 113 | 11 pairs of ribs (HP:0000878) | 1.80720835 |
| 114 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.80544426 |
| 115 | Abnormality of the umbilical cord (HP:0010881) | 1.80018616 |
| 116 | Increased CSF lactate (HP:0002490) | 1.79344055 |
| 117 | Small intestinal stenosis (HP:0012848) | 1.79198780 |
| 118 | Duodenal stenosis (HP:0100867) | 1.79198780 |
| 119 | Neoplasm of the colon (HP:0100273) | 1.78364122 |
| 120 | Abnormal number of erythroid precursors (HP:0012131) | 1.77139006 |
| 121 | Entropion (HP:0000621) | 1.77105317 |
| 122 | Atresia of the external auditory canal (HP:0000413) | 1.76559722 |
| 123 | Abnormality of the carotid arteries (HP:0005344) | 1.76559300 |
| 124 | Lip pit (HP:0100267) | 1.76376919 |
| 125 | Ectopic kidney (HP:0000086) | 1.75980454 |
| 126 | Spinal muscular atrophy (HP:0007269) | 1.75851063 |
| 127 | Absent thumb (HP:0009777) | 1.75068837 |
| 128 | Pancytopenia (HP:0001876) | 1.74982138 |
| 129 | Resting tremor (HP:0002322) | 1.74950664 |
| 130 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.74610019 |
| 131 | Overlapping toe (HP:0001845) | 1.73699362 |
| 132 | Glossoptosis (HP:0000162) | 1.73266442 |
| 133 | Ragged-red muscle fibers (HP:0003200) | 1.72420128 |
| 134 | Cafe-au-lait spot (HP:0000957) | 1.72351148 |
| 135 | Right ventricular cardiomyopathy (HP:0011663) | 1.72348676 |
| 136 | Skin tags (HP:0010609) | 1.70489790 |
| 137 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.69979399 |
| 138 | Hepatic necrosis (HP:0002605) | 1.69140576 |
| 139 | Sparse eyelashes (HP:0000653) | 1.68131530 |
| 140 | Posterior subcapsular cataract (HP:0007787) | 1.67604239 |
| 141 | CNS hypomyelination (HP:0003429) | 1.67420128 |
| 142 | Gout (HP:0001997) | 1.67282188 |
| 143 | Exercise intolerance (HP:0003546) | 1.67082390 |
| 144 | Neuroblastoma (HP:0003006) | 1.66489847 |
| 145 | Primitive neuroectodermal tumor (HP:0030065) | 1.66489847 |
| 146 | Neuroblastic tumors (HP:0004376) | 1.66489847 |
| 147 | Peripheral primitive neuroectodermal neoplasm (HP:0030067) | 1.66489847 |
| 148 | Angiofibromas (HP:0010615) | 1.65188688 |
| 149 | Adenoma sebaceum (HP:0009720) | 1.65188688 |
| 150 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.65102356 |
| 151 | Abnormal trabecular bone morphology (HP:0100671) | 1.64552345 |
| 152 | Long foot (HP:0001833) | 1.63940886 |
| 153 | Short humerus (HP:0005792) | 1.63754977 |
| 154 | Megaloblastic anemia (HP:0001889) | 1.62869907 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.35264979 |
| 2 | NEK1 | 3.98307546 |
| 3 | TSSK6 | 3.89195925 |
| 4 | CDC7 | 3.71813031 |
| 5 | VRK2 | 3.29222645 |
| 6 | EPHA2 | 3.11305237 |
| 7 | NME2 | 3.11015210 |
| 8 | WEE1 | 3.00057356 |
| 9 | CDK12 | 2.93211392 |
| 10 | PBK | 2.80710400 |
| 11 | SMG1 | 2.67580657 |
| 12 | TTK | 2.60151255 |
| 13 | RPS6KB2 | 2.58337754 |
| 14 | PLK4 | 2.47073226 |
| 15 | SRPK1 | 2.45972720 |
| 16 | LATS2 | 2.31212125 |
| 17 | EIF2AK1 | 2.30591568 |
| 18 | PLK3 | 2.18442758 |
| 19 | PLK1 | 1.93035791 |
| 20 | LATS1 | 1.91486292 |
| 21 | STK38L | 1.88640662 |
| 22 | AKT3 | 1.82091574 |
| 23 | ALK | 1.71539728 |
| 24 | CDK7 | 1.63770505 |
| 25 | BRD4 | 1.62022335 |
| 26 | PDK3 | 1.59642892 |
| 27 | PDK4 | 1.59642892 |
| 28 | BRSK2 | 1.55967339 |
| 29 | MKNK1 | 1.54276621 |
| 30 | SCYL2 | 1.52136527 |
| 31 | NEK2 | 1.51112379 |
| 32 | ATR | 1.49478320 |
| 33 | AURKB | 1.47389198 |
| 34 | CHEK1 | 1.46369956 |
| 35 | PASK | 1.44721893 |
| 36 | ICK | 1.41730532 |
| 37 | PRKCI | 1.38489029 |
| 38 | CHEK2 | 1.35225069 |
| 39 | MST4 | 1.34858437 |
| 40 | NME1 | 1.31781777 |
| 41 | MKNK2 | 1.24941400 |
| 42 | IRAK3 | 1.23527209 |
| 43 | AURKA | 1.21543338 |
| 44 | CDK4 | 1.18697990 |
| 45 | PNCK | 1.15983394 |
| 46 | TAF1 | 1.15651574 |
| 47 | STK10 | 1.12460298 |
| 48 | EIF2AK3 | 1.11980058 |
| 49 | CDK2 | 1.05934494 |
| 50 | MAP3K10 | 1.04737789 |
| 51 | ATM | 1.02655973 |
| 52 | BRAF | 1.01874478 |
| 53 | CSNK1E | 1.01396958 |
| 54 | BRSK1 | 0.99696599 |
| 55 | PAK4 | 0.89286057 |
| 56 | CDK6 | 0.89144679 |
| 57 | TRIB3 | 0.88322538 |
| 58 | STK4 | 0.84835548 |
| 59 | CDK8 | 0.84419806 |
| 60 | TAOK2 | 0.84040515 |
| 61 | CDK1 | 0.82485842 |
| 62 | MAP3K8 | 0.82389210 |
| 63 | CSNK2A2 | 0.82125643 |
| 64 | ACVR1B | 0.81365975 |
| 65 | MAP3K4 | 0.78628208 |
| 66 | FGFR1 | 0.77265016 |
| 67 | CLK1 | 0.76603953 |
| 68 | PDK2 | 0.75635634 |
| 69 | MST1R | 0.73233807 |
| 70 | MTOR | 0.73096652 |
| 71 | AKT2 | 0.70145086 |
| 72 | BCKDK | 0.67257131 |
| 73 | STK3 | 0.65839066 |
| 74 | DAPK1 | 0.64772760 |
| 75 | EEF2K | 0.64139595 |
| 76 | EIF2AK2 | 0.63868381 |
| 77 | ZAK | 0.61648546 |
| 78 | TGFBR1 | 0.60904304 |
| 79 | CDC42BPA | 0.57059285 |
| 80 | BMX | 0.56511222 |
| 81 | CSNK2A1 | 0.56247445 |
| 82 | ERBB4 | 0.56186965 |
| 83 | MARK3 | 0.55981588 |
| 84 | CDK9 | 0.55238154 |
| 85 | MAPKAPK3 | 0.54729963 |
| 86 | PRKDC | 0.52939695 |
| 87 | ARAF | 0.51729391 |
| 88 | CSNK1G3 | 0.51438963 |
| 89 | PKN2 | 0.48911474 |
| 90 | STK38 | 0.48177120 |
| 91 | CDK11A | 0.47999640 |
| 92 | KDR | 0.47560794 |
| 93 | TESK1 | 0.47416368 |
| 94 | MAPK14 | 0.46832538 |
| 95 | STK16 | 0.45461535 |
| 96 | GSK3B | 0.44069231 |
| 97 | LMTK2 | 0.43970296 |
| 98 | RAF1 | 0.43370069 |
| 99 | CDK18 | 0.42411461 |
| 100 | CDK15 | 0.42172655 |
| 101 | PLK2 | 0.40439340 |
| 102 | PAK1 | 0.39863347 |
| 103 | MELK | 0.39676093 |
| 104 | CSNK1A1L | 0.39539268 |
| 105 | CAMK1D | 0.38795592 |
| 106 | NUAK1 | 0.38780511 |
| 107 | SIK3 | 0.37745587 |
| 108 | CSNK1G1 | 0.37047535 |
| 109 | CDK14 | 0.36663127 |
| 110 | MAPK10 | 0.36467077 |
| 111 | MAPKAPK5 | 0.36399305 |
| 112 | MAPK11 | 0.36132798 |
| 113 | RPS6KB1 | 0.34061746 |
| 114 | TRIM28 | 0.33496711 |
| 115 | CSNK1D | 0.32688284 |
| 116 | TESK2 | 0.32155075 |
| 117 | VRK1 | 0.30814310 |
| 118 | DYRK3 | 0.30793685 |
| 119 | PIM1 | 0.29125932 |
| 120 | RPS6KA4 | 0.27780565 |
| 121 | OBSCN | 0.27730107 |
| 122 | PINK1 | 0.26341071 |
| 123 | CCNB1 | 0.26211130 |
| 124 | PRKACB | 0.26144204 |
| 125 | CAMK1G | 0.25230421 |
| 126 | TAOK1 | 0.25046701 |
| 127 | MAPK1 | 0.23584607 |
| 128 | MAPK8 | 0.23187404 |
| 129 | LIMK1 | 0.22407477 |
| 130 | PRPF4B | 0.21754249 |
| 131 | FER | 0.21706305 |
| 132 | PTK2 | 0.20612923 |
| 133 | STK24 | 0.20431083 |
| 134 | GRK6 | 0.19683850 |
| 135 | MAPK9 | 0.19567825 |
| 136 | MAP3K11 | 0.19257782 |
| 137 | MAP2K3 | 0.19025826 |
| 138 | AKT1 | 0.18998565 |
| 139 | RPS6KA3 | 0.18650888 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 4.58589906 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.23141139 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 3.78504750 |
| 4 | RNA transport_Homo sapiens_hsa03013 | 3.65012384 |
| 5 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 3.60648385 |
| 6 | Spliceosome_Homo sapiens_hsa03040 | 3.55631662 |
| 7 | Proteasome_Homo sapiens_hsa03050 | 3.15013970 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 3.04470298 |
| 9 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.87759670 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.72203807 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.42281217 |
| 12 | Cell cycle_Homo sapiens_hsa04110 | 2.40885798 |
| 13 | Base excision repair_Homo sapiens_hsa03410 | 2.31886766 |
| 14 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.28497955 |
| 15 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.16183849 |
| 16 | RNA degradation_Homo sapiens_hsa03018 | 2.08781785 |
| 17 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.05397445 |
| 18 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.87568615 |
| 19 | Ribosome_Homo sapiens_hsa03010 | 1.86656511 |
| 20 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.86615976 |
| 21 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.84325301 |
| 22 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.78553760 |
| 23 | Basal transcription factors_Homo sapiens_hsa03022 | 1.75852301 |
| 24 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.68053046 |
| 25 | Carbon metabolism_Homo sapiens_hsa01200 | 1.34251309 |
| 26 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.30011150 |
| 27 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.28428666 |
| 28 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.25836383 |
| 29 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.12872064 |
| 30 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.12490352 |
| 31 | Purine metabolism_Homo sapiens_hsa00230 | 1.12028450 |
| 32 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.11426485 |
| 33 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.09775819 |
| 34 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.05993025 |
| 35 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.05791145 |
| 36 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.04356208 |
| 37 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.00073768 |
| 38 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.99108529 |
| 39 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.89229261 |
| 40 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.86192505 |
| 41 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.84727685 |
| 42 | Phototransduction_Homo sapiens_hsa04744 | 0.83097919 |
| 43 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.80746047 |
| 44 | Thyroid cancer_Homo sapiens_hsa05216 | 0.80500899 |
| 45 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.79891140 |
| 46 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.77724049 |
| 47 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.71910613 |
| 48 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.68400321 |
| 49 | Protein export_Homo sapiens_hsa03060 | 0.67065273 |
| 50 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.64217089 |
| 51 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.62597470 |
| 52 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.62017157 |
| 53 | Lysine degradation_Homo sapiens_hsa00310 | 0.60437200 |
| 54 | Galactose metabolism_Homo sapiens_hsa00052 | 0.58693665 |
| 55 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.57197762 |
| 56 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.55265115 |
| 57 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.52528354 |
| 58 | Huntingtons disease_Homo sapiens_hsa05016 | 0.52150571 |
| 59 | Adherens junction_Homo sapiens_hsa04520 | 0.51616194 |
| 60 | Circadian rhythm_Homo sapiens_hsa04710 | 0.51442206 |
| 61 | Tight junction_Homo sapiens_hsa04530 | 0.48727739 |
| 62 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.48223683 |
| 63 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.47397223 |
| 64 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.46602573 |
| 65 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.44962997 |
| 66 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.43993071 |
| 67 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.43341300 |
| 68 | HTLV-I infection_Homo sapiens_hsa05166 | 0.41983275 |
| 69 | Sulfur relay system_Homo sapiens_hsa04122 | 0.41513363 |
| 70 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.41089584 |
| 71 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.40048939 |
| 72 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.39084011 |
| 73 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.38160096 |
| 74 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.37103109 |
| 75 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.36336721 |
| 76 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.36247260 |
| 77 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.35811633 |
| 78 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.35678712 |
| 79 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.32979264 |
| 80 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.32957107 |
| 81 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.31265786 |
| 82 | Colorectal cancer_Homo sapiens_hsa05210 | 0.30031430 |
| 83 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.29877710 |
| 84 | Alzheimers disease_Homo sapiens_hsa05010 | 0.29809933 |
| 85 | Nicotine addiction_Homo sapiens_hsa05033 | 0.29143985 |
| 86 | Bladder cancer_Homo sapiens_hsa05219 | 0.28647648 |
| 87 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.28601908 |
| 88 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.26434910 |
| 89 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.26249208 |
| 90 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.25451017 |
| 91 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.23734709 |
| 92 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.22434842 |
| 93 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.21745158 |
| 94 | Metabolic pathways_Homo sapiens_hsa01100 | 0.21731880 |
| 95 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.20512983 |
| 96 | Apoptosis_Homo sapiens_hsa04210 | 0.20425756 |
| 97 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.19943535 |
| 98 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.19510600 |
| 99 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.18793025 |
| 100 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.18579305 |
| 101 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.18104274 |
| 102 | Parkinsons disease_Homo sapiens_hsa05012 | 0.17761510 |
| 103 | Alcoholism_Homo sapiens_hsa05034 | 0.17387385 |
| 104 | Shigellosis_Homo sapiens_hsa05131 | 0.17387040 |
| 105 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.17086079 |
| 106 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.16639390 |
| 107 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.16333325 |
| 108 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.16141993 |
| 109 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.15206541 |
| 110 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.14934747 |
| 111 | Prostate cancer_Homo sapiens_hsa05215 | 0.13391386 |
| 112 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.12518076 |
| 113 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.11994629 |
| 114 | Endometrial cancer_Homo sapiens_hsa05213 | 0.11021530 |
| 115 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.10112891 |
| 116 | Pathways in cancer_Homo sapiens_hsa05200 | 0.09157848 |
| 117 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.08653725 |
| 118 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.07048210 |
| 119 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.06655331 |
| 120 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.05561189 |
| 121 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.04041542 |
| 122 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.03815528 |
| 123 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.03287337 |
| 124 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.03169147 |
| 125 | Melanoma_Homo sapiens_hsa05218 | 0.02432218 |
| 126 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.02202369 |

