LATS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.38911164
2nuclear pore organization (GO:0006999)5.66853195
3pore complex assembly (GO:0046931)4.93541765
4monoubiquitinated protein deubiquitination (GO:0035520)4.63107313
5neural tube formation (GO:0001841)4.47065224
6mitotic sister chromatid cohesion (GO:0007064)4.37566775
7interkinetic nuclear migration (GO:0022027)4.26755139
8peptidyl-lysine trimethylation (GO:0018023)4.19653638
9phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.16493195
10regulation of RNA export from nucleus (GO:0046831)3.99163208
11histone H3-K9 methylation (GO:0051567)3.97169772
12regulation of centriole replication (GO:0046599)3.94192583
13negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.92183963
14negative regulation of translation, ncRNA-mediated (GO:0040033)3.92183963
15regulation of translation, ncRNA-mediated (GO:0045974)3.92183963
16cytoplasmic mRNA processing body assembly (GO:0033962)3.91693120
17histone H3-K4 trimethylation (GO:0080182)3.84518511
18microtubule anchoring (GO:0034453)3.79460571
19insulin-like growth factor receptor signaling pathway (GO:0048009)3.76808270
20definitive hemopoiesis (GO:0060216)3.76395626
21histone H3-K4 methylation (GO:0051568)3.72261732
22microtubule nucleation (GO:0007020)3.71595601
23histone lysine methylation (GO:0034968)3.66142516
24regulation of meiosis I (GO:0060631)3.62709567
25COPI coating of Golgi vesicle (GO:0048205)3.45954702
26Golgi transport vesicle coating (GO:0048200)3.45954702
27histone H3-K9 modification (GO:0061647)3.43875008
28histone H3-K36 demethylation (GO:0070544)3.41821827
29protein K48-linked deubiquitination (GO:0071108)3.40286911
30histone H3-K9 demethylation (GO:0033169)3.37609262
31Golgi to endosome transport (GO:0006895)3.36660052
32N-terminal protein amino acid acetylation (GO:0006474)3.27081713
33stress granule assembly (GO:0034063)3.23886297
34centriole replication (GO:0007099)3.21944092
35peptidyl-lysine methylation (GO:0018022)3.21346119
36histone lysine demethylation (GO:0070076)3.14622394
37embryonic retina morphogenesis in camera-type eye (GO:0060059)3.14332585
38histone H4-K16 acetylation (GO:0043984)3.12053193
39negative regulation of fatty acid transport (GO:2000192)3.10395552
40regulation of centrosome duplication (GO:0010824)3.10026175
41histone demethylation (GO:0016577)3.09108842
42regulation of DNA endoreduplication (GO:0032875)3.08226602
43regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.01984290
44positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.01984290
45growth hormone receptor signaling pathway (GO:0060396)2.99456698
46behavioral response to ethanol (GO:0048149)2.98138208
47histone methylation (GO:0016571)2.97842944
48cell adhesion mediated by integrin (GO:0033627)2.97664552
49collagen fibril organization (GO:0030199)2.97647794
50cellular response to ethanol (GO:0071361)2.97292494
51negative regulation of neurotransmitter secretion (GO:0046929)2.95912731
52protein prenylation (GO:0018342)2.93410268
53prenylation (GO:0097354)2.93410268
54regulation of nucleobase-containing compound transport (GO:0032239)2.90673180
55protein K11-linked deubiquitination (GO:0035871)2.88953079
56nucleus localization (GO:0051647)2.88255875
57pre-miRNA processing (GO:0031054)2.87510191
58regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.85695312
59COPII vesicle coating (GO:0048208)2.84229879
60protein demethylation (GO:0006482)2.83748832
61protein dealkylation (GO:0008214)2.83748832
62sister chromatid cohesion (GO:0007062)2.81659644
63somite rostral/caudal axis specification (GO:0032525)2.75520824
64regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.72231778
65positive regulation of histone deacetylation (GO:0031065)2.71147969
66phospholipid translocation (GO:0045332)2.70972390
67lipid translocation (GO:0034204)2.70972390
68positive regulation of granulocyte differentiation (GO:0030854)2.70815384
69regulation of histone H3-K27 methylation (GO:0061085)2.70719842
70protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.70712647
71regulation of histone H3-K4 methylation (GO:0051569)2.69576472
72neuron projection extension involved in neuron projection guidance (GO:1902284)2.66952900
73axon extension involved in axon guidance (GO:0048846)2.66952900
74protein localization to Golgi apparatus (GO:0034067)2.66326547
75* hippo signaling (GO:0035329)2.66136229
76protein localization to endosome (GO:0036010)2.63529523
77snRNA transcription (GO:0009301)2.62054074
78negative regulation of mRNA processing (GO:0050686)2.62053426
79positive regulation of glycogen biosynthetic process (GO:0045725)2.61501232
80positive regulation of mRNA catabolic process (GO:0061014)2.60706472
81activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.59756656
82chondrocyte proliferation (GO:0035988)2.59567152
83positive regulation of fatty acid beta-oxidation (GO:0032000)2.59443053
84regulation of protein polyubiquitination (GO:1902914)2.59080995
85positive regulation by host of viral transcription (GO:0043923)2.58866427
86positive regulation of mRNA processing (GO:0050685)2.58467945
87pyrimidine dimer repair (GO:0006290)2.58184857
88negative regulation of histone methylation (GO:0031061)2.58124989
89positive regulation of p38MAPK cascade (GO:1900745)2.57449646
90RNA localization (GO:0006403)2.57436200
91acrosome assembly (GO:0001675)2.57365701
92nucleus organization (GO:0006997)2.55659478
93gene silencing by RNA (GO:0031047)2.55549456
94vesicle coating (GO:0006901)2.54915532
95cellular response to growth hormone stimulus (GO:0071378)2.53965797
96embryonic hemopoiesis (GO:0035162)2.53882745
97protein localization to cilium (GO:0061512)2.53024852
98NLS-bearing protein import into nucleus (GO:0006607)2.52601724
99dorsal/ventral axis specification (GO:0009950)2.52302290
100branching involved in prostate gland morphogenesis (GO:0060442)2.52013640
101regulation of NFAT protein import into nucleus (GO:0051532)2.51991187
102histone mRNA catabolic process (GO:0071044)2.51485909
103regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51126138
104phosphatidylethanolamine metabolic process (GO:0046337)2.50878434
105regulation of histone methylation (GO:0031060)2.49246452
106chondrocyte development (GO:0002063)2.48646963
107maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.47317321
108regulation of centrosome cycle (GO:0046605)2.47126152
109protein deubiquitination (GO:0016579)2.46657468
110positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.46579269
111camera-type eye morphogenesis (GO:0048593)2.46451692
112DNA topological change (GO:0006265)2.46152003
113protein alkylation (GO:0008213)2.46140525
114protein methylation (GO:0006479)2.46140525
115peptidyl-threonine dephosphorylation (GO:0035970)2.45751900
116regulation of pigment cell differentiation (GO:0050932)2.45490335
117negative regulation of neurotransmitter transport (GO:0051589)2.45415160
118positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.44755505
119phosphatidylethanolamine biosynthetic process (GO:0006646)2.44299694
120positive regulation of nuclease activity (GO:0032075)2.43498789
121positive regulation of protein import into nucleus, translocation (GO:0033160)2.41784950
122positive regulation of male gonad development (GO:2000020)2.41600887
123male sex determination (GO:0030238)2.41124356
124early endosome to late endosome transport (GO:0045022)2.41008748
125exocrine pancreas development (GO:0031017)2.39361343
126apoptotic cell clearance (GO:0043277)2.39314219
127negative regulation of mRNA metabolic process (GO:1903312)2.39009037
128peptidyl-lysine dimethylation (GO:0018027)2.38910638
129retrograde transport, vesicle recycling within Golgi (GO:0000301)2.38701119
130semaphorin-plexin signaling pathway (GO:0071526)2.38168975
131protein targeting to Golgi (GO:0000042)2.37320241
132glucocorticoid receptor signaling pathway (GO:0042921)2.36969778
133establishment of protein localization to Golgi (GO:0072600)2.35429362
134regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.35236020
135mesodermal cell differentiation (GO:0048333)2.34461694
136positive regulation of hormone biosynthetic process (GO:0046886)2.34411844
137type B pancreatic cell development (GO:0003323)2.33292225
138nerve growth factor signaling pathway (GO:0038180)2.29884468
139cellular response to vitamin D (GO:0071305)2.29749572
140prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.28324304
141endoplasmic reticulum unfolded protein response (GO:0030968)2.27507963
142mesenchymal-epithelial cell signaling (GO:0060638)2.27263958
143regulation of cholesterol homeostasis (GO:2000188)2.26846550
144germ cell migration (GO:0008354)2.24426174
145regulation of membrane protein ectodomain proteolysis (GO:0051043)2.22872653
146hemidesmosome assembly (GO:0031581)2.22426479
147midgut development (GO:0007494)2.22131428
148positive regulation of glycogen metabolic process (GO:0070875)2.22061276
149craniofacial suture morphogenesis (GO:0097094)2.20448990
150ER-nucleus signaling pathway (GO:0006984)2.18934879
151cellular response to unfolded protein (GO:0034620)2.18189539
152protein localization to cell surface (GO:0034394)2.17760285
153skin morphogenesis (GO:0043589)2.17487059
154endodermal cell differentiation (GO:0035987)2.16989769
155epithelial cell differentiation involved in prostate gland development (GO:0060742)2.16655912
156regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.16465075
157gland morphogenesis (GO:0022612)2.16404760
158retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.16320781
159regulation of nuclease activity (GO:0032069)2.15787848
160regulation of fatty acid beta-oxidation (GO:0031998)2.15424058
161endoplasmic reticulum organization (GO:0007029)2.14588880
162corticosteroid receptor signaling pathway (GO:0031958)2.13997661
163positive regulation of glycolytic process (GO:0045821)2.13676910
164cytoskeletal anchoring at plasma membrane (GO:0007016)2.13367608
165radial glial cell differentiation (GO:0060019)2.13272190
166cell migration involved in sprouting angiogenesis (GO:0002042)2.12800893
167gastrulation with mouth forming second (GO:0001702)2.11104093
168positive regulation of catenin import into nucleus (GO:0035413)2.10839388
169protein retention in ER lumen (GO:0006621)2.09002822
170cellular response to vitamin (GO:0071295)2.08627793
171planar cell polarity pathway involved in neural tube closure (GO:0090179)2.06978181
172sequestering of extracellular ligand from receptor (GO:0035581)2.06820605
173substrate-dependent cell migration (GO:0006929)2.06425881
174coronary vasculature morphogenesis (GO:0060977)2.04327638
175embryonic viscerocranium morphogenesis (GO:0048703)2.03263252
176embryonic camera-type eye morphogenesis (GO:0048596)2.02660626
177hormone catabolic process (GO:0042447)2.00897362
178regulation of glucose import in response to insulin stimulus (GO:2001273)1.99291671
179endocardial cushion development (GO:0003197)1.99253217
180negative regulation of lipid transport (GO:0032369)1.99148763
181positive regulation of mesenchymal cell proliferation (GO:0002053)1.98268821
182eye morphogenesis (GO:0048592)1.98225852
183platelet-derived growth factor receptor signaling pathway (GO:0048008)1.98186593
184renal system development (GO:0072001)1.97348765
185cartilage development involved in endochondral bone morphogenesis (GO:0060351)1.96742533
186polarized epithelial cell differentiation (GO:0030859)1.96564437
187regulation of polysaccharide biosynthetic process (GO:0032885)1.96359627
188retina vasculature morphogenesis in camera-type eye (GO:0061299)1.95328608
189antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G1.94874824
190macroautophagy (GO:0016236)1.91321830
191positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)1.90434504
192regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)1.90434504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.92772848
2POU3F2_20337985_ChIP-ChIP_501MEL_Human2.87538947
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.87390048
4IGF1R_20145208_ChIP-Seq_DFB_Human2.68017236
5GBX2_23144817_ChIP-Seq_PC3_Human2.45847001
6FUS_26573619_Chip-Seq_HEK293_Human2.41148370
7TAF15_26573619_Chip-Seq_HEK293_Human2.40648905
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40236378
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.25469598
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23024756
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22190445
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.21505676
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.21235649
14ZNF217_24962896_ChIP-Seq_MCF-7_Human2.21189185
15E2F7_22180533_ChIP-Seq_HELA_Human2.17559833
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11522968
17EWS_26573619_Chip-Seq_HEK293_Human2.09858627
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.07831535
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06881407
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.03664949
21CLOCK_20551151_ChIP-Seq_293T_Human2.00082434
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.97083528
23ZNF274_21170338_ChIP-Seq_K562_Hela1.80914179
24* STAT3_23295773_ChIP-Seq_U87_Human1.79282488
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.77663209
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76718585
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74499776
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.74464562
29SMAD4_21799915_ChIP-Seq_A2780_Human1.72695592
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.72427738
31P300_19829295_ChIP-Seq_ESCs_Human1.69885599
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.69848413
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.69008061
34VDR_22108803_ChIP-Seq_LS180_Human1.65870306
35TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.64769096
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.64258674
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.63774449
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.60890127
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59638915
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59570949
41TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.58777257
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.57759383
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54498785
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.53437749
45TP53_16413492_ChIP-PET_HCT116_Human1.50864334
46CJUN_26792858_Chip-Seq_BT549_Human1.50837244
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50114677
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49361611
49ER_23166858_ChIP-Seq_MCF-7_Human1.48995123
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48778751
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.48657984
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.47940003
53BRD4_25478319_ChIP-Seq_HGPS_Human1.47507265
54* TCF4_23295773_ChIP-Seq_U87_Human1.47286601
55AHR_22903824_ChIP-Seq_MCF-7_Human1.47117961
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46060878
57CBP_20019798_ChIP-Seq_JUKART_Human1.46060878
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45366889
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.44960633
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43992360
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43753850
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.43521395
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42267087
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41835253
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41835253
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41135065
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41135065
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.41060502
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.39201359
70* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38828029
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37798264
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37615659
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.37093015
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36605955
75GATA1_22025678_ChIP-Seq_K562_Human1.36433745
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.35868783
77RXR_22158963_ChIP-Seq_LIVER_Mouse1.34197340
78EP300_21415370_ChIP-Seq_HL-1_Mouse1.33646078
79CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33635578
80AR_21572438_ChIP-Seq_LNCaP_Human1.31928343
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31484893
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31131218
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30690165
84FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.30646804
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.29386811
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28900421
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.28602257
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28382754
89RXR_22108803_ChIP-Seq_LS180_Human1.27166775
90* FLI1_21867929_ChIP-Seq_TH2_Mouse1.26437749
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26375016
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26058465
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25924411
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25153012
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.24126760
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23909214
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.23028512
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22605020
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.22589111
100ESR2_21235772_ChIP-Seq_MCF-7_Human1.22240896
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21900044
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.21755516
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20191636
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19839783
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19785684
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19785684
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18090462
108WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17811677
109* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17722439
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17557262
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.17173200
112SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17047284
113TP53_18474530_ChIP-ChIP_U2OS_Human1.16451224
114P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16353569
115PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15687464
116* GATA2_21666600_ChIP-Seq_HMVEC_Human1.15476174
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13692149
118Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13289451
119RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12838564
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12732549
121AR_25329375_ChIP-Seq_VCAP_Human1.11716196
122* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11238113
123OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11233130
124P53_22387025_ChIP-Seq_ESCs_Mouse1.10641550
125PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10004078
126ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09945188
127RUNX2_22187159_ChIP-Seq_PCA_Human1.09689437
128CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09231040
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09027094
130ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09009154
131CDX2_22108803_ChIP-Seq_LS180_Human1.08980363
132RUNX_20019798_ChIP-Seq_JUKART_Human1.08630810
133ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08320022
134SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08012334
135TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07803251
136NFE2_27457419_Chip-Seq_LIVER_Mouse1.07295846
137KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07226196
138VDR_24787735_ChIP-Seq_THP-1_Human1.07112786
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07109107
140FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05916003
141NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05262641
142HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05170144
143* CRX_20693478_ChIP-Seq_RETINA_Mouse1.05055895
144TP63_23658742_ChIP-Seq_EP156T_Human1.04746959
145FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04481745
146SOX2_21211035_ChIP-Seq_LN229_Gbm1.04238704
147SOX2_20726797_ChIP-Seq_SW620_Human1.03508741
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03492890
149SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03491640
150CDX2_20551321_ChIP-Seq_CACO-2_Human1.03442826
151KDM2B_26808549_Chip-Seq_K562_Human1.03064008
152RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03026609
153KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02732561
154IRF1_19129219_ChIP-ChIP_H3396_Human1.01920410
155STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01653691
156PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00174396
157KDM2B_26808549_Chip-Seq_JURKAT_Human0.99855042
158OCT4_18555785_Chip-Seq_ESCs_Mouse0.99331616
159PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98801407
160FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98055084
161KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97713782
162TCF7_22412390_ChIP-Seq_EML_Mouse0.96822682
163* GATA6_25053715_ChIP-Seq_YYC3_Human0.96131844
164BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94667235
165BCAT_22108803_ChIP-Seq_LS180_Human0.94599899
166STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94557384
167HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94235555
168YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94075777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.42583095
2MP0009697_abnormal_copulation4.42400326
3MP0003705_abnormal_hypodermis_morpholog4.26441516
4MP0008438_abnormal_cutaneous_collagen3.48101918
5MP0003300_gastrointestinal_ulcer3.28809371
6MP0003890_abnormal_embryonic-extraembry3.19626333
7MP0009780_abnormal_chondrocyte_physiolo3.03554806
8MP0005275_abnormal_skin_tensile2.53265378
9MP0000569_abnormal_digit_pigmentation2.50362684
10MP0005503_abnormal_tendon_morphology2.48659805
11MP0004043_abnormal_pH_regulation2.41357510
12MP0005076_abnormal_cell_differentiation2.37601550
13MP0010352_gastrointestinal_tract_polyps2.35535379
14MP0010234_abnormal_vibrissa_follicle2.23959492
15MP0001299_abnormal_eye_distance/2.16434222
16MP0005248_abnormal_Harderian_gland2.16146676
17MP0000015_abnormal_ear_pigmentation2.15732266
18MP0003045_fibrosis2.12563912
19MP0002877_abnormal_melanocyte_morpholog2.10293314
20MP0009384_cardiac_valve_regurgitation2.05303433
21MP0005187_abnormal_penis_morphology2.04468411
22MP0008058_abnormal_DNA_repair2.04201263
23MP0002896_abnormal_bone_mineralization1.99172933
24MP0003252_abnormal_bile_duct1.94549018
25MP0002102_abnormal_ear_morphology1.89642781
26MP0006054_spinal_hemorrhage1.88173740
27MP0004272_abnormal_basement_membrane1.85310427
28MP0004134_abnormal_chest_morphology1.66135477
29MP0005257_abnormal_intraocular_pressure1.65438811
30MP0003763_abnormal_thymus_physiology1.61232531
31MP0008877_abnormal_DNA_methylation1.60460274
32MP0000733_abnormal_muscle_development1.58654713
33MP0003123_paternal_imprinting1.57296285
34MP0003091_abnormal_cell_migration1.56595554
35MP0010678_abnormal_skin_adnexa1.51778730
36MP0004808_abnormal_hematopoietic_stem1.51155605
37MP0009053_abnormal_anal_canal1.50791941
38MP0000537_abnormal_urethra_morphology1.46630495
39MP0002396_abnormal_hematopoietic_system1.44267578
40MP0002168_other_aberrant_phenotype1.44204385
41MP0005409_darkened_coat_color1.44036096
42MP0002166_altered_tumor_susceptibility1.43421891
43MP0003121_genomic_imprinting1.42794472
44MP0005360_urolithiasis1.42269009
45MP0003656_abnormal_erythrocyte_physiolo1.41789907
46MP0003868_abnormal_feces_composition1.40952010
47MP0003566_abnormal_cell_adhesion1.37405953
48MP0004185_abnormal_adipocyte_glucose1.36595835
49MP0000428_abnormal_craniofacial_morphol1.35818896
50MP0002139_abnormal_hepatobiliary_system1.35691374
51MP0005365_abnormal_bile_salt1.34491089
52MP0000778_abnormal_nervous_system1.33893320
53MP0003183_abnormal_peptide_metabolism1.33892961
54MP0004264_abnormal_extraembryonic_tissu1.32757388
55MP0005220_abnormal_exocrine_pancreas1.32272561
56MP0002060_abnormal_skin_morphology1.27844031
57MP0001177_atelectasis1.27249584
58MP0000516_abnormal_urinary_system1.25072009
59MP0005367_renal/urinary_system_phenotyp1.25072009
60MP0005623_abnormal_meninges_morphology1.23274936
61MP0002088_abnormal_embryonic_growth/wei1.22709341
62MP0003279_aneurysm1.22299934
63MP0008961_abnormal_basal_metabolism1.21685331
64MP0003303_peritoneal_inflammation1.21577681
65MP0003984_embryonic_growth_retardation1.21378561
66MP0000003_abnormal_adipose_tissue1.20476887
67MP0000383_abnormal_hair_follicle1.18972905
68MP0001958_emphysema1.18285856
69MP0003935_abnormal_craniofacial_develop1.17201709
70MP0003942_abnormal_urinary_system1.17011460
71MP0010094_abnormal_chromosome_stability1.16135754
72MP0000427_abnormal_hair_cycle1.14704647
73MP0001879_abnormal_lymphatic_vessel1.13252632
74MP0009250_abnormal_appendicular_skeleto1.12834513
75MP0002115_abnormal_skeleton_extremities1.12261967
76MP0004885_abnormal_endolymph1.11931260
77MP0000579_abnormal_nail_morphology1.10652310
78MP0005508_abnormal_skeleton_morphology1.09952535
79MP0002009_preneoplasia1.09875482
80MP0002108_abnormal_muscle_morphology1.09581941
81MP0010307_abnormal_tumor_latency1.08797441
82MP0005380_embryogenesis_phenotype1.08331963
83MP0001672_abnormal_embryogenesis/_devel1.08331963
84MP0003698_abnormal_male_reproductive1.08248086
85MP0000163_abnormal_cartilage_morphology1.07500361
86MP0003937_abnormal_limbs/digits/tail_de1.07465587
87MP0001188_hyperpigmentation1.06887456
88MP0003077_abnormal_cell_cycle1.06372439
89MP0004130_abnormal_muscle_cell1.05243768
90MP0002092_abnormal_eye_morphology1.04629930
91MP0003950_abnormal_plasma_membrane1.04619834
92MP0003786_premature_aging1.04305284
93MP0000703_abnormal_thymus_morphology1.04035229
94* MP0000631_abnormal_neuroendocrine_gland1.02904971
95MP0003111_abnormal_nucleus_morphology1.02854208
96MP0000647_abnormal_sebaceous_gland1.02627599
97MP0001666_abnormal_nutrient_absorption1.01682923
98MP0003755_abnormal_palate_morphology1.01110473
99MP0002697_abnormal_eye_size1.00678477
100MP0003385_abnormal_body_wall1.00303288
101MP0010368_abnormal_lymphatic_system1.00167733
102MP0005375_adipose_tissue_phenotype0.99870050
103MP0000566_synostosis0.99195831
104MP0002928_abnormal_bile_duct0.98660043
105MP0005023_abnormal_wound_healing0.98097896
106MP0005379_endocrine/exocrine_gland_phen0.97327684
107MP0002086_abnormal_extraembryonic_tissu0.96744849
108MP0001944_abnormal_pancreas_morphology0.96166713
109MP0009115_abnormal_fat_cell0.95544402
110MP0002234_abnormal_pharynx_morphology0.95380061
111MP0001286_abnormal_eye_development0.95209445
112MP0001929_abnormal_gametogenesis0.95048240
113MP0005551_abnormal_eye_electrophysiolog0.93749213
114MP0002084_abnormal_developmental_patter0.93522220
115MP0002006_tumorigenesis0.93235519
116MP0003115_abnormal_respiratory_system0.93075432
117MP0001849_ear_inflammation0.92130790
118MP0001697_abnormal_embryo_size0.92069918
119MP0005666_abnormal_adipose_tissue0.90420532
120MP0000432_abnormal_head_morphology0.90162811
121MP0008995_early_reproductive_senescence0.89048208
122MP0000377_abnormal_hair_follicle0.88589317
123MP0001270_distended_abdomen0.88126553
124MP0002998_abnormal_bone_remodeling0.87987992
125MP0002113_abnormal_skeleton_development0.86784385
126MP0000767_abnormal_smooth_muscle0.85833721
127MP0003567_abnormal_fetal_cardiomyocyte0.85682150
128MP0003195_calcinosis0.85316939
129MP0002098_abnormal_vibrissa_morphology0.84907026
130MP0002109_abnormal_limb_morphology0.84890964
131MP0000462_abnormal_digestive_system0.83927112
132MP0002090_abnormal_vision0.83719179
133MP0003283_abnormal_digestive_organ0.83329071
134MP0002909_abnormal_adrenal_gland0.83287724
135MP0000350_abnormal_cell_proliferation0.82913835
136MP0005174_abnormal_tail_pigmentation0.81703893
137MP0002282_abnormal_trachea_morphology0.80540642
138MP0010030_abnormal_orbit_morphology0.79614273
139MP0005085_abnormal_gallbladder_physiolo0.79038784
140MP0000534_abnormal_ureter_morphology0.78382924
141MP0003943_abnormal_hepatobiliary_system0.78341999
142MP0004197_abnormal_fetal_growth/weight/0.78101671
143MP0001324_abnormal_eye_pigmentation0.77392566
144MP0001346_abnormal_lacrimal_gland0.76876767
145MP0001915_intracranial_hemorrhage0.76773981
146MP0009703_decreased_birth_body0.76677776
147MP0002925_abnormal_cardiovascular_devel0.76615465
148MP0003861_abnormal_nervous_system0.76247995
149MP0002075_abnormal_coat/hair_pigmentati0.75328184
150MP0000371_diluted_coat_color0.73663690
151MP0001730_embryonic_growth_arrest0.72095938
152MP0002114_abnormal_axial_skeleton0.70484504
153MP0005253_abnormal_eye_physiology0.69909728
154MP0002085_abnormal_embryonic_tissue0.69618150
155MP0005310_abnormal_salivary_gland0.68898857
156* MP0002081_perinatal_lethality0.67076139
157MP0005266_abnormal_metabolism0.66453384
158MP0004484_altered_response_of0.66445705
159MP0001784_abnormal_fluid_regulation0.66357537
160MP0004957_abnormal_blastocyst_morpholog0.65337716
161MP0004233_abnormal_muscle_weight0.64409721
162MP0005386_behavior/neurological_phenoty0.64226522
163MP0004924_abnormal_behavior0.64226522
164MP0000465_gastrointestinal_hemorrhage0.63993771
165MP0001145_abnormal_male_reproductive0.62922780
166MP0002095_abnormal_skin_pigmentation0.62792150
167MP0002938_white_spotting0.62185597
168MP0003221_abnormal_cardiomyocyte_apopto0.61055326
169MP0002177_abnormal_outer_ear0.60978791
170MP0005391_vision/eye_phenotype0.58666859
171MP0008007_abnormal_cellular_replicative0.57416767

Predicted human phenotypes

RankGene SetZ-score
1Macroorchidism (HP:0000053)3.84778756
2Papillary thyroid carcinoma (HP:0002895)3.48238050
3Acute myeloid leukemia (HP:0004808)3.42418113
4Shallow orbits (HP:0000586)3.42304920
5Subacute progressive viral hepatitis (HP:0006572)3.15946256
6Protrusio acetabuli (HP:0003179)3.02012828
7Short 4th metacarpal (HP:0010044)2.99938229
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.99938229
9Aortic aneurysm (HP:0004942)2.93999723
10Cerebral aneurysm (HP:0004944)2.79020574
11Hyperventilation (HP:0002883)2.67323533
12Truncal obesity (HP:0001956)2.67201684
13Curly hair (HP:0002212)2.66887009
14Premature rupture of membranes (HP:0001788)2.66879292
15Hypoplastic ischia (HP:0003175)2.59352746
16Abnormality of the nasal septum (HP:0000419)2.59346584
17Broad metatarsal (HP:0001783)2.57839401
18Neoplasm of the adrenal cortex (HP:0100641)2.57705958
19Exostoses (HP:0100777)2.51823463
20Mitral valve prolapse (HP:0001634)2.51464867
21Chromsome breakage (HP:0040012)2.50745147
22Atrophic scars (HP:0001075)2.49386736
23Protruding tongue (HP:0010808)2.48977704
24Overgrowth (HP:0001548)2.46090112
25Sandal gap (HP:0001852)2.44844620
26Fair hair (HP:0002286)2.43470069
27Deep philtrum (HP:0002002)2.43401717
28Genetic anticipation (HP:0003743)2.43381372
29Abnormality of the renal medulla (HP:0100957)2.42949069
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41612590
31Aortic dissection (HP:0002647)2.41219485
32Thyroid carcinoma (HP:0002890)2.40731887
33Abnormality of the renal cortex (HP:0011035)2.39961074
34Nephronophthisis (HP:0000090)2.38680193
35Short chin (HP:0000331)2.36797343
36Hypoplastic iliac wings (HP:0002866)2.33064302
37Hepatoblastoma (HP:0002884)2.32279338
38Widely spaced teeth (HP:0000687)2.30100445
39Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.29682397
40Abnormality of the 4th metacarpal (HP:0010012)2.28124717
41Abnormality of the ischium (HP:0003174)2.27535198
42Lymphangioma (HP:0100764)2.25873976
43Cystic hygroma (HP:0000476)2.20370487
44Enlarged penis (HP:0000040)2.20196919
45Aneurysm (HP:0002617)2.18813268
46Vitreoretinal degeneration (HP:0000655)2.17562373
47Nephroblastoma (Wilms tumor) (HP:0002667)2.17068563
48Cervical subluxation (HP:0003308)2.16903183
49Dilatation of the ascending aorta (HP:0005111)2.14457643
50Drooling (HP:0002307)2.12849906
51Epiphyseal dysplasia (HP:0002656)2.12239964
52Abnormality of the fingertips (HP:0001211)2.10912600
53Long eyelashes (HP:0000527)2.09221586
54Long clavicles (HP:0000890)2.08794063
55Arterial tortuosity (HP:0005116)2.07992560
56Narrow palate (HP:0000189)2.07689722
57Embryonal renal neoplasm (HP:0011794)2.06142251
58Disproportionate tall stature (HP:0001519)2.05557557
59Stomach cancer (HP:0012126)2.04964392
60Neonatal hypoglycemia (HP:0001998)2.04229582
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.04157353
62Osteolytic defects of the hand bones (HP:0009699)2.04157353
63Intestinal atresia (HP:0011100)2.02286168
64Severe combined immunodeficiency (HP:0004430)2.01979435
65Facial hemangioma (HP:0000329)2.00768040
66Aqueductal stenosis (HP:0002410)2.00442396
67Midline defect of the nose (HP:0004122)2.00201330
68Asymmetry of the thorax (HP:0001555)1.99754595
69Prominent nose (HP:0000448)1.98879205
70Absent frontal sinuses (HP:0002688)1.97883547
71Vascular tortuosity (HP:0004948)1.97277375
72Thick eyebrow (HP:0000574)1.96895120
73Abnormality of the left ventricular outflow tract (HP:0011103)1.96778637
74Subaortic stenosis (HP:0001682)1.96778637
75Excessive salivation (HP:0003781)1.96396637
76Cutis marmorata (HP:0000965)1.95679643
77Increased density of long bones (HP:0006392)1.95364162
78Gonadotropin excess (HP:0000837)1.95030112
79Biliary tract neoplasm (HP:0100574)1.93695462
80Buphthalmos (HP:0000557)1.93489691
81Diastasis recti (HP:0001540)1.92763810
82Wormian bones (HP:0002645)1.92532897
83Peritonitis (HP:0002586)1.90569695
84Hypoplastic labia majora (HP:0000059)1.88127392
85Spinal cord lesions (HP:0100561)1.87538014
86Syringomyelia (HP:0003396)1.87538014
87Thin bony cortex (HP:0002753)1.87528022
88Tibial bowing (HP:0002982)1.87036438
89Coronal craniosynostosis (HP:0004440)1.86952302
90Epidermoid cyst (HP:0200040)1.86463396
91Heterotopia (HP:0002282)1.86034892
92Absent speech (HP:0001344)1.85616051
93Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.85208596
94Broad ribs (HP:0000885)1.84455909
95Glioma (HP:0009733)1.83696685
96Deviation of the hallux (HP:0010051)1.83368573
97Rectal prolapse (HP:0002035)1.83364566
98Thyroiditis (HP:0100646)1.83240778
99Gaze-evoked nystagmus (HP:0000640)1.83120982
100Limited elbow extension (HP:0001377)1.82937016
101Myocardial infarction (HP:0001658)1.82721639
102Genu recurvatum (HP:0002816)1.82006654
103Transitional cell carcinoma of the bladder (HP:0006740)1.81707844
104Spondylolisthesis (HP:0003302)1.81614685
105Turricephaly (HP:0000262)1.81429870
106Ankle contracture (HP:0006466)1.81243207
107Infantile muscular hypotonia (HP:0008947)1.81084833
108Medulloblastoma (HP:0002885)1.80405806
109Depressed nasal tip (HP:0000437)1.80104840
110Tapered finger (HP:0001182)1.79510884
111Bladder diverticulum (HP:0000015)1.79310241
112Astrocytoma (HP:0009592)1.78980524
113Abnormality of the astrocytes (HP:0100707)1.78980524
114Chronic hepatic failure (HP:0100626)1.78933937
115Generalized hypopigmentation of hair (HP:0011358)1.78276710
116Ulnar bowing (HP:0003031)1.77577631
117Volvulus (HP:0002580)1.76888362
118Hallux valgus (HP:0001822)1.76648402
119Abnormality of chromosome stability (HP:0003220)1.75233285
120Wide intermamillary distance (HP:0006610)1.74611517
121Thickened calvaria (HP:0002684)1.74597982
122Bell-shaped thorax (HP:0001591)1.74527930
123Hip dysplasia (HP:0001385)1.73499930
124Cupped ribs (HP:0000887)1.73494052
125Neoplasm of the small intestine (HP:0100833)1.72531265
126Highly arched eyebrow (HP:0002553)1.72442133
127Chorioretinal atrophy (HP:0000533)1.71697674
128Abnormality of chromosome segregation (HP:0002916)1.71407522
129Hematochezia (HP:0002573)1.71185784
130Bladder carcinoma (HP:0002862)1.71170897
131Bladder neoplasm (HP:0009725)1.71170897
132Abnormality of the distal phalanx of the thumb (HP:0009617)1.70732312
133Vertebral arch anomaly (HP:0008438)1.70518048
134Gastroesophageal reflux (HP:0002020)1.70055850
135Hyperglycemia (HP:0003074)1.69620451
136Abnormality of the lumbar spine (HP:0100712)1.69136635
137Ectopic kidney (HP:0000086)1.68028287
138Postaxial foot polydactyly (HP:0001830)1.67331300
139Partial agenesis of the corpus callosum (HP:0001338)1.67091407
140Abnormal foot bone ossification (HP:0010675)1.66661426
141Acute lymphatic leukemia (HP:0006721)1.66392569
142Clubbing of toes (HP:0100760)1.65697995
143Hypoplastic nipples (HP:0002557)1.65480676
144Basal cell carcinoma (HP:0002671)1.65021705
145Abnormality of the labia majora (HP:0012881)1.64791168
146Deep venous thrombosis (HP:0002625)1.64183189
147Thoracolumbar scoliosis (HP:0002944)1.63671275
148Broad thumb (HP:0011304)1.63505615
149Germ cell neoplasia (HP:0100728)1.63350170
150Micronodular cirrhosis (HP:0001413)1.63171761
151Capillary hemangiomas (HP:0005306)1.61838342
152Ectopia lentis (HP:0001083)1.61820211
153Overlapping toe (HP:0001845)1.61731185
154Blue sclerae (HP:0000592)1.60839294
155Absent eyebrow (HP:0002223)1.60185033
156Large earlobe (HP:0009748)1.59954997
157Neonatal short-limb short stature (HP:0008921)1.59553969
158Coarse hair (HP:0002208)1.59109903
159High anterior hairline (HP:0009890)1.58867176
160Hamartoma (HP:0010566)1.58461572
161Renal cortical cysts (HP:0000803)1.58368212
162Abnormality of the parathyroid morphology (HP:0011766)1.58328937
163Submucous cleft hard palate (HP:0000176)1.58264846
164Mitral stenosis (HP:0001718)1.58126391
165Gastrointestinal carcinoma (HP:0002672)1.57750499
166Malignant gastrointestinal tract tumors (HP:0006749)1.57750499
167Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.57623993
168Flat acetabular roof (HP:0003180)1.57177115
169Uterine leiomyosarcoma (HP:0002891)1.57032148
170Leiomyosarcoma (HP:0100243)1.57032148
171Abnormality of the wing of the ilium (HP:0011867)1.57027369
172Soft skin (HP:0000977)1.57016825
173Short foot (HP:0001773)1.56148345
174Cupped ear (HP:0000378)1.55478643
175Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.55377240
176Mildly elevated creatine phosphokinase (HP:0008180)1.54206123
177Fragile skin (HP:0001030)1.54090618
178Hyperextensible skin (HP:0000974)1.53743668
179Back pain (HP:0003418)1.53560053
180Joint laxity (HP:0001388)1.53134628
181Wide anterior fontanel (HP:0000260)1.52470356
182Long toe (HP:0010511)1.51759519
183Mesomelia (HP:0003027)1.51113488

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.83334204
2FRK3.29895210
3SIK13.15417634
4PLK43.07269214
5TRIB32.88744696
6IRAK12.87663840
7EPHA32.83354714
8DDR22.34348766
9IRAK22.28388962
10PTK62.27481227
11PRPF4B2.19830912
12ERN12.19225419
13CAMK1D2.16152265
14PKN22.13684510
15PDGFRA2.08852478
16RIPK12.07163048
17CDK122.03111716
18CAMK1G2.03063241
19PNCK2.02147327
20FGFR21.96215061
21NLK1.92667522
22SCYL21.86271951
23FGFR31.85381607
24INSRR1.81433205
25MAP4K21.77812866
26TTN1.69889639
27PDGFRB1.51503087
28TAOK31.50814488
29* LATS11.49994245
30YES11.48897040
31CDC71.45594397
32ICK1.45191453
33BRSK21.44950455
34CDK31.44635402
35MAP3K21.44145975
36CDK61.42144252
37EPHB11.41083500
38MAP3K101.37486551
39ACVR1B1.35945957
40FGFR41.35446713
41MST1R1.33728425
42BCR1.32408647
43BRD41.31062728
44JAK11.30284940
45EIF2AK31.26418513
46TNIK1.24805898
47MTOR1.24033848
48DMPK1.20781823
49PTK21.20703852
50EPHB21.17731007
51BMX1.17492696
52MAP3K41.17247229
53HIPK21.15700221
54FGFR11.13357807
55NEK91.12558490
56STK38L1.10840286
57* STK31.10702030
58MET1.09938518
59SIK21.09027588
60DYRK1B1.08268982
61SGK31.08213805
62MKNK21.07584364
63ERBB31.06941775
64CSNK1A1L1.03460716
65TGFBR21.01758633
66EEF2K1.00902444
67ERBB21.00467494
68FER0.99524800
69RET0.98224444
70PAK20.97719012
71CHUK0.96851089
72TRIM280.96618781
73WNK10.96541780
74TEC0.92204667
75PRKCH0.91899284
76CASK0.90661940
77NTRK30.89946097
78MAP3K60.86090440
79WEE10.80803165
80TAOK10.78371802
81PLK20.78119943
82ATM0.77835162
83CAMK40.77613159
84PAK30.76731041
85SGK20.76591401
86LRRK20.74745809
87GSK3A0.74020278
88TRPM70.73510359
89PIK3CA0.73405479
90MAP3K140.69677413
91CHEK10.67720646
92TAF10.67472932
93INSR0.63739681
94MAP3K30.60239383
95CDK90.59141348
96MAP3K70.59086664
97MARK20.58725985
98JAK30.58575711
99PIM10.58043714
100CAMKK20.56336077
101PIK3CG0.55338243
102CAMKK10.55215605
103MAPK100.55120101
104EGFR0.54977819
105STK380.54747877
106CSNK1G20.54516317
107PRKAA20.54461955
108PRKD10.54390134
109MKNK10.53667902
110GSK3B0.52079246
111PRKAA10.51417513
112ATR0.51211607
113JAK20.50970078
114IGF1R0.50750020
115RPS6KA20.49446624
116KSR10.49232325
117CDK20.46270141
118RPS6KA40.45966010
119ZAK0.45277573
120MELK0.44719588
121SGK10.44696838
122ROCK10.44443193
123ITK0.43104789
124* CDK10.42084318
125CDC42BPA0.41824228
126BMPR20.41749877
127SGK4940.41688198
128SGK2230.41688198
129ALK0.41217608
130TYRO30.41169493
131MAPK140.41069114
132ERBB40.40892615
133CSNK1G10.40808037
134TYK20.40073050
135BTK0.39752318
136CHEK20.39654276
137CSK0.39592296
138ABL10.38463757
139STK110.38261430
140NTRK10.37954768
141MAPK80.37325915
142NEK20.37225441
143SRC0.37062729
144HCK0.36593902
145STK100.36346209
146MAPK130.35950481
147EPHA20.34978989
148MAPK10.34729985
149PRKD30.33544737
150CSNK1D0.32727357
151TXK0.32039080
152STK390.31993220
153SRPK10.31889044
154MAPK70.31861396
155PTK2B0.31154591
156STK40.30700912
157RPS6KB10.30393098

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.53263376
2ECM-receptor interaction_Homo sapiens_hsa045121.71209873
3Adherens junction_Homo sapiens_hsa045201.59460991
4Non-homologous end-joining_Homo sapiens_hsa034501.58795612
5Lysine degradation_Homo sapiens_hsa003101.54971375
6Maturity onset diabetes of the young_Homo sapiens_hsa049501.52118360
7Focal adhesion_Homo sapiens_hsa045101.49457674
8mRNA surveillance pathway_Homo sapiens_hsa030151.48769429
9Jak-STAT signaling pathway_Homo sapiens_hsa046301.48075714
10Long-term depression_Homo sapiens_hsa047301.47757922
11Fanconi anemia pathway_Homo sapiens_hsa034601.42354346
12Chronic myeloid leukemia_Homo sapiens_hsa052201.42197066
13Proteoglycans in cancer_Homo sapiens_hsa052051.41002768
14Endometrial cancer_Homo sapiens_hsa052131.34483462
15Dorso-ventral axis formation_Homo sapiens_hsa043201.34327816
16Cell cycle_Homo sapiens_hsa041101.33892324
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33461242
18Type II diabetes mellitus_Homo sapiens_hsa049301.31798832
19Protein digestion and absorption_Homo sapiens_hsa049741.30254479
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28388665
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23103994
22Insulin resistance_Homo sapiens_hsa049311.22097042
23Small cell lung cancer_Homo sapiens_hsa052221.20652392
24Basal transcription factors_Homo sapiens_hsa030221.17986531
25mTOR signaling pathway_Homo sapiens_hsa041501.17505151
26Sulfur metabolism_Homo sapiens_hsa009201.16693076
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14957452
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14069611
29Prostate cancer_Homo sapiens_hsa052151.13670232
30MicroRNAs in cancer_Homo sapiens_hsa052061.13616314
31Amoebiasis_Homo sapiens_hsa051461.12270906
32Basal cell carcinoma_Homo sapiens_hsa052171.10775775
33Ether lipid metabolism_Homo sapiens_hsa005651.10637142
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08866660
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08018282
36Glioma_Homo sapiens_hsa052141.05059934
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04317909
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01888000
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01183207
40Pancreatic cancer_Homo sapiens_hsa052121.01173826
41Measles_Homo sapiens_hsa051620.98875240
42RNA transport_Homo sapiens_hsa030130.98313041
43Prolactin signaling pathway_Homo sapiens_hsa049170.97773585
44Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96921637
45Renal cell carcinoma_Homo sapiens_hsa052110.96313489
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95968633
47Toxoplasmosis_Homo sapiens_hsa051450.94908311
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94701520
49Long-term potentiation_Homo sapiens_hsa047200.94270108
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.90171493
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89910719
52* Hippo signaling pathway_Homo sapiens_hsa043900.88158556
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87564104
54TGF-beta signaling pathway_Homo sapiens_hsa043500.87011288
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.86907296
56Nicotine addiction_Homo sapiens_hsa050330.86170285
57Taste transduction_Homo sapiens_hsa047420.84476753
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83875598
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.83286373
60AMPK signaling pathway_Homo sapiens_hsa041520.82212871
61FoxO signaling pathway_Homo sapiens_hsa040680.81516696
62Bile secretion_Homo sapiens_hsa049760.81367628
63Thyroid cancer_Homo sapiens_hsa052160.80703507
64Axon guidance_Homo sapiens_hsa043600.80506095
65RNA degradation_Homo sapiens_hsa030180.80281396
66Non-small cell lung cancer_Homo sapiens_hsa052230.79833595
67ErbB signaling pathway_Homo sapiens_hsa040120.79189247
68Estrogen signaling pathway_Homo sapiens_hsa049150.79165882
69PPAR signaling pathway_Homo sapiens_hsa033200.79013232
70Caffeine metabolism_Homo sapiens_hsa002320.78847805
71Complement and coagulation cascades_Homo sapiens_hsa046100.78048902
72Selenocompound metabolism_Homo sapiens_hsa004500.77925928
73Oocyte meiosis_Homo sapiens_hsa041140.77732354
74Hedgehog signaling pathway_Homo sapiens_hsa043400.77356131
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77277524
76p53 signaling pathway_Homo sapiens_hsa041150.76537964
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76131178
78Bladder cancer_Homo sapiens_hsa052190.75654162
79Ovarian steroidogenesis_Homo sapiens_hsa049130.75134573
80Fat digestion and absorption_Homo sapiens_hsa049750.74783164
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74376427
82Viral carcinogenesis_Homo sapiens_hsa052030.74367034
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74205560
84Colorectal cancer_Homo sapiens_hsa052100.73157221
85Insulin signaling pathway_Homo sapiens_hsa049100.72971621
86Regulation of autophagy_Homo sapiens_hsa041400.72287940
87ABC transporters_Homo sapiens_hsa020100.72088921
88Cholinergic synapse_Homo sapiens_hsa047250.71130646
89Renin secretion_Homo sapiens_hsa049240.71060653
90Arginine biosynthesis_Homo sapiens_hsa002200.70769132
91Wnt signaling pathway_Homo sapiens_hsa043100.70466034
92Platelet activation_Homo sapiens_hsa046110.70099975
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69041352
94Viral myocarditis_Homo sapiens_hsa054160.68224390
95Thyroid hormone synthesis_Homo sapiens_hsa049180.68122487
96Fatty acid biosynthesis_Homo sapiens_hsa000610.67398265
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.67202944
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66641086
99TNF signaling pathway_Homo sapiens_hsa046680.65698519
100Osteoclast differentiation_Homo sapiens_hsa043800.65627742
101Glutamatergic synapse_Homo sapiens_hsa047240.65281299
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.64581977
103MAPK signaling pathway_Homo sapiens_hsa040100.64074937
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63496597
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63186383
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63173400
107VEGF signaling pathway_Homo sapiens_hsa043700.62733409
108B cell receptor signaling pathway_Homo sapiens_hsa046620.62171985
109Notch signaling pathway_Homo sapiens_hsa043300.61913238
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61555250
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60923593
112Hepatitis C_Homo sapiens_hsa051600.60574943
113Pathways in cancer_Homo sapiens_hsa052000.59547159
114N-Glycan biosynthesis_Homo sapiens_hsa005100.59361030
115Herpes simplex infection_Homo sapiens_hsa051680.59210975
116Acute myeloid leukemia_Homo sapiens_hsa052210.59207628
117Serotonergic synapse_Homo sapiens_hsa047260.58835465
118Tight junction_Homo sapiens_hsa045300.58415284
119Rap1 signaling pathway_Homo sapiens_hsa040150.57504347
120Melanoma_Homo sapiens_hsa052180.55868848
121Pancreatic secretion_Homo sapiens_hsa049720.55232569
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54958078
123Hepatitis B_Homo sapiens_hsa051610.54268106
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.53986656
125Choline metabolism in cancer_Homo sapiens_hsa052310.53759597
126Melanogenesis_Homo sapiens_hsa049160.53380862
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.53342942
128Malaria_Homo sapiens_hsa051440.53154974
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.53131560
130Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52244160
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51877821
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51718036
133Dilated cardiomyopathy_Homo sapiens_hsa054140.51631001
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51306789
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51242363
136Circadian rhythm_Homo sapiens_hsa047100.51212051
137T cell receptor signaling pathway_Homo sapiens_hsa046600.50857931
138Inositol phosphate metabolism_Homo sapiens_hsa005620.50632371
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.50578300
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.50359702
141Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50353830
142Glucagon signaling pathway_Homo sapiens_hsa049220.50231720
143Insulin secretion_Homo sapiens_hsa049110.49293692
144cAMP signaling pathway_Homo sapiens_hsa040240.48945820
145Circadian entrainment_Homo sapiens_hsa047130.48189342
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48151450
147Ras signaling pathway_Homo sapiens_hsa040140.48111440
148Salivary secretion_Homo sapiens_hsa049700.48042023
149Calcium signaling pathway_Homo sapiens_hsa040200.47876923
150Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46841022
151Oxytocin signaling pathway_Homo sapiens_hsa049210.46820657
152Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46488973

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