LATS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular basement membrane development (GO:0032836)4.79706762
2glomerular visceral epithelial cell development (GO:0072015)4.72648538
3vascular endothelial growth factor signaling pathway (GO:0038084)4.51565915
4glomerular epithelial cell development (GO:0072310)4.29161651
5cell adhesion mediated by integrin (GO:0033627)4.04598722
6lymph vessel development (GO:0001945)3.99732725
7retina vasculature morphogenesis in camera-type eye (GO:0061299)3.82521667
8protein heterotrimerization (GO:0070208)3.74893360
9basement membrane organization (GO:0071711)3.69442579
10collagen fibril organization (GO:0030199)3.65554543
11blood vessel maturation (GO:0001955)3.61545956
12chondrocyte proliferation (GO:0035988)3.60997134
13neuron projection extension involved in neuron projection guidance (GO:1902284)3.50692159
14axon extension involved in axon guidance (GO:0048846)3.50692159
15cell migration involved in sprouting angiogenesis (GO:0002042)3.48401624
16cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.47743813
17endodermal cell differentiation (GO:0035987)3.43886926
18wound healing, spreading of epidermal cells (GO:0035313)3.38838912
19negative regulation of fatty acid transport (GO:2000192)3.36742480
20lymphangiogenesis (GO:0001946)3.33331240
21regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.30814754
22renal filtration (GO:0097205)3.29065865
23plasma membrane repair (GO:0001778)3.25514466
24cell-substrate adherens junction assembly (GO:0007045)3.20566097
25focal adhesion assembly (GO:0048041)3.20566097
26pinocytosis (GO:0006907)3.20147767
27glomerular filtration (GO:0003094)3.17287904
28sequestering of extracellular ligand from receptor (GO:0035581)3.16703561
29kidney mesenchyme development (GO:0072074)3.15517495
30response to laminar fluid shear stress (GO:0034616)3.13557514
31protein localization to endosome (GO:0036010)3.12085209
32atrioventricular valve morphogenesis (GO:0003181)3.10444845
33substrate-dependent cell migration (GO:0006929)3.08911578
34stress fiber assembly (GO:0043149)3.08412378
35response to fluid shear stress (GO:0034405)3.05959068
36apoptotic cell clearance (GO:0043277)3.05926496
37substrate adhesion-dependent cell spreading (GO:0034446)3.00675312
38vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.96189741
39mesodermal cell differentiation (GO:0048333)2.94734157
40blood vessel endothelial cell migration (GO:0043534)2.93426002
41endocardial cushion development (GO:0003197)2.92277178
42positive regulation of endothelial cell apoptotic process (GO:2000353)2.90581860
43negative regulation of chondrocyte differentiation (GO:0032331)2.87619906
44germ cell migration (GO:0008354)2.85774394
45regulation of transforming growth factor beta2 production (GO:0032909)2.84902737
46hyaluronan catabolic process (GO:0030214)2.84344772
47endothelial cell morphogenesis (GO:0001886)2.84029779
48chondrocyte development (GO:0002063)2.83160237
49skin morphogenesis (GO:0043589)2.81741589
50positive regulation of osteoblast proliferation (GO:0033690)2.81679988
51membrane raft organization (GO:0031579)2.78057285
52regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.76898077
53collagen metabolic process (GO:0032963)2.76759322
54endothelium development (GO:0003158)2.76125446
55patterning of blood vessels (GO:0001569)2.75613012
56positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.74804704
57epithelial cell-cell adhesion (GO:0090136)2.74800405
58metanephric mesenchyme development (GO:0072075)2.74077053
59endothelial cell chemotaxis (GO:0035767)2.73865456
60embryonic process involved in female pregnancy (GO:0060136)2.73003745
61positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.72728745
62paraxial mesoderm development (GO:0048339)2.71688239
63regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71633387
64wound healing, spreading of cells (GO:0044319)2.71301267
65regulation of p38MAPK cascade (GO:1900744)2.70349682
66multicellular organismal macromolecule metabolic process (GO:0044259)2.67990601
67planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67952933
68positive regulation of p38MAPK cascade (GO:1900745)2.67864050
69collagen catabolic process (GO:0030574)2.67820589
70regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.66858534
71regulation of tight junction assembly (GO:2000810)2.66579242
72* hippo signaling (GO:0035329)2.66506814
73mRNA transcription (GO:0009299)2.64172166
74positive regulation of epithelial to mesenchymal transition (GO:0010718)2.63964566
75positive regulation of extracellular matrix organization (GO:1903055)2.63522995
76extracellular fibril organization (GO:0043206)2.62572481
77pericardium development (GO:0060039)2.62553176
78branching involved in salivary gland morphogenesis (GO:0060445)2.62198212
79endothelial tube morphogenesis (GO:0061154)2.61550944
80morphogenesis of an endothelium (GO:0003159)2.61550944
81positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.60377408
82barbed-end actin filament capping (GO:0051016)2.60357709
83cell migration involved in heart development (GO:0060973)2.58025196
84regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.57992429
85adherens junction assembly (GO:0034333)2.57438960
86protein localization to cell surface (GO:0034394)2.56701855
87hypotonic response (GO:0006971)2.56597775
88positive regulation of blood vessel endothelial cell migration (GO:0043536)2.56154243
89protein targeting to plasma membrane (GO:0072661)2.55569051
90fibril organization (GO:0097435)2.54685106
91dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.53538036
92multicellular organismal catabolic process (GO:0044243)2.52275708
93multicellular organismal metabolic process (GO:0044236)2.50227145
94negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.49916087
95dermatan sulfate biosynthetic process (GO:0030208)2.49637128
96insulin-like growth factor receptor signaling pathway (GO:0048009)2.49456988
97coronary vasculature morphogenesis (GO:0060977)2.48390944
98glomerulus development (GO:0032835)2.47291466
99regulation of SMAD protein import into nucleus (GO:0060390)2.47061763
100hemidesmosome assembly (GO:0031581)2.46888744
101platelet-derived growth factor receptor signaling pathway (GO:0048008)2.46674633
102pathway-restricted SMAD protein phosphorylation (GO:0060389)2.44600579
103extracellular matrix disassembly (GO:0022617)2.43988352
104cell-substrate junction assembly (GO:0007044)2.43712590
105cell-matrix adhesion (GO:0007160)2.43404445
106regulation of early endosome to late endosome transport (GO:2000641)2.42267318
107positive regulation of receptor recycling (GO:0001921)2.41459488
108cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.40873637
109regulation of transforming growth factor beta1 production (GO:0032908)2.40508100
110bone trabecula formation (GO:0060346)2.40425293
111negative regulation of catenin import into nucleus (GO:0035414)2.40339287
112regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.40097117
113negative regulation of anoikis (GO:2000811)2.40021570
114negative regulation of homotypic cell-cell adhesion (GO:0034111)2.39798783
115venous blood vessel morphogenesis (GO:0048845)2.39241976
116mRNA transcription from RNA polymerase II promoter (GO:0042789)2.37588262
117regulation of integrin-mediated signaling pathway (GO:2001044)2.37448866
118cell-substrate adhesion (GO:0031589)2.37156607
119cytoskeletal anchoring at plasma membrane (GO:0007016)2.37059203
120chondroitin sulfate biosynthetic process (GO:0030206)2.36695087
121fibroblast migration (GO:0010761)2.35883387
122cell proliferation involved in metanephros development (GO:0072203)2.34768553
123surfactant homeostasis (GO:0043129)2.34038227
124sprouting angiogenesis (GO:0002040)2.34027617
125mesenchymal-epithelial cell signaling (GO:0060638)2.33808090
126positive regulation of cartilage development (GO:0061036)2.32765826
127growth hormone receptor signaling pathway (GO:0060396)2.32696425
128heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.32161173
129positive regulation of endothelial cell migration (GO:0010595)2.31964953
130regulation of membrane protein ectodomain proteolysis (GO:0051043)2.31689650
131craniofacial suture morphogenesis (GO:0097094)2.30987406
132lung lobe morphogenesis (GO:0060463)2.30807790
133positive regulation of adherens junction organization (GO:1903393)2.30204642
134negative regulation of smooth muscle cell migration (GO:0014912)2.30070688
135dermatan sulfate metabolic process (GO:0030205)2.29913301
136positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.29760722
137cardiac myofibril assembly (GO:0055003)2.27015479
138endothelial cell proliferation (GO:0001935)2.26850060
139extracellular matrix assembly (GO:0085029)2.26357059
140positive regulation of histone deacetylation (GO:0031065)2.23909290
141artery development (GO:0060840)2.23847260
142endothelial cell migration (GO:0043542)2.23702885
143blood vessel remodeling (GO:0001974)2.23579411

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.31352798
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.36554281
3* FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.29884206
4* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.28738190
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.73504136
6CLOCK_20551151_ChIP-Seq_293T_Human2.57532548
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.47226269
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.25335479
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.19565745
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.14834291
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12522239
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.12266456
13CJUN_26792858_Chip-Seq_BT549_Human2.09872968
14RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.07715928
15GATA2_21666600_ChIP-Seq_HMVEC_Human2.04029220
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.98289388
17EGR1_19374776_ChIP-ChIP_THP-1_Human1.94157573
18CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.89988396
19PPAR_26484153_Chip-Seq_NCI-H1993_Human1.89762107
20* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.85940054
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.83759116
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.79928049
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.79928049
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.79928049
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.79149119
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78207428
27* ESR2_21235772_ChIP-Seq_MCF-7_Human1.73903130
28RUNX_20019798_ChIP-Seq_JUKART_Human1.69927610
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.67727116
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67630989
31ZNF263_19887448_ChIP-Seq_K562_Human1.66139109
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65298633
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57931699
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57062073
35* BRD4_25478319_ChIP-Seq_HGPS_Human1.56568731
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54119232
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.54006428
38TBX20_22328084_ChIP-Seq_HEART_Mouse1.52655916
39TBX20_22080862_ChIP-Seq_HEART_Mouse1.52655916
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49214130
41SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.47086402
42SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.47086402
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45807956
44* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41246074
45KDM2B_26808549_Chip-Seq_DND41_Human1.41043677
46JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38436872
47* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35547065
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35437521
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35200595
50NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35200595
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35021156
52JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34407460
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32838938
54* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29059558
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28760870
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27884927
57* TP53_22127205_ChIP-Seq_IMR90_Human1.27644469
58VDR_24787735_ChIP-Seq_THP-1_Human1.27447433
59ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.26567479
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25786555
61* ATF3_27146783_Chip-Seq_COLON_Human1.25347495
62* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25246557
63* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24907679
64* UBF1/2_26484160_Chip-Seq_HMECs_Human1.24072250
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23780581
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22795110
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.22728277
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21888871
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21551342
70AHR_22903824_ChIP-Seq_MCF-7_Human1.19179625
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16620306
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15565295
73EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15484478
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15323785
75KDM2B_26808549_Chip-Seq_K562_Human1.14408264
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14046007
77NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13990338
78SMC1_22415368_ChIP-Seq_MEFs_Mouse1.13773007
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13410038
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.13374112
81VDR_24763502_ChIP-Seq_THP-1_Human1.12404436
82* TP53_16413492_ChIP-PET_HCT116_Human1.11317853
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.11185906
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11122112
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10582991
86* TCF7_22412390_ChIP-Seq_EML_Mouse1.10302451
87* IRF8_27001747_Chip-Seq_BMDM_Mouse1.09778355
88TP53_18474530_ChIP-ChIP_U2OS_Human1.09176321
89FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08415082
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08127868
91FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08112019
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07484090
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06913382
94NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05990203
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05701434
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05068258
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04450065
98TCF4_18268006_ChIP-ChIP_LS174T_Human1.03229853
99GATA1_19941826_ChIP-Seq_K562_Human1.02059864
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01658649
101* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01619365
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00924578
103ARNT_22903824_ChIP-Seq_MCF-7_Human0.99608097
104PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99181436
105* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99007180
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98936544
107GATA2_19941826_ChIP-Seq_K562_Human0.98503671
108* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98131115
109CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97787112
110* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96442196
111ISL1_27105846_Chip-Seq_CPCs_Mouse0.94528235
112PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.94500391
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94412404
114SA1_22415368_ChIP-Seq_MEFs_Mouse0.94381981
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94232273
116* SOX2_20726797_ChIP-Seq_SW620_Human0.93777738
117STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93641778
118SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93640990
119LXR_22158963_ChIP-Seq_LIVER_Mouse0.92718256
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91948955
121RACK7_27058665_Chip-Seq_MCF-7_Human0.91936291
122RXR_22108803_ChIP-Seq_LS180_Human0.91645815
123TP63_23658742_ChIP-Seq_EP156T_Human0.91487663
124MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.90714551
125FOXA2_19822575_ChIP-Seq_HepG2_Human0.90262345

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.58447872
2MP0005275_abnormal_skin_tensile3.55441755
3MP0003279_aneurysm3.50265686
4MP0003705_abnormal_hypodermis_morpholog3.43388255
5MP0004272_abnormal_basement_membrane3.36884603
6MP0005503_abnormal_tendon_morphology3.13464645
7MP0010368_abnormal_lymphatic_system2.98450226
8MP0001958_emphysema2.97519049
9MP0005623_abnormal_meninges_morphology2.94201595
10MP0001879_abnormal_lymphatic_vessel2.61007223
11MP0009384_cardiac_valve_regurgitation2.43211260
12MP0003566_abnormal_cell_adhesion2.29338677
13MP0003091_abnormal_cell_migration2.11072722
14MP0004084_abnormal_cardiac_muscle2.07109611
15MP0006054_spinal_hemorrhage2.04384010
16MP0003300_gastrointestinal_ulcer1.97122324
17MP0000767_abnormal_smooth_muscle1.95460272
18MP0002295_abnormal_pulmonary_circulatio1.85328000
19MP0010030_abnormal_orbit_morphology1.71866649
20MP0003828_pulmonary_edema1.67393413
21MP0005023_abnormal_wound_healing1.64265144
22MP0002877_abnormal_melanocyte_morpholog1.63998259
23MP0003045_fibrosis1.60228945
24* MP0000733_abnormal_muscle_development1.48777320
25MP0000013_abnormal_adipose_tissue1.44624897
26MP0010352_gastrointestinal_tract_polyps1.41719167
27MP0002166_altered_tumor_susceptibility1.37230867
28MP0005508_abnormal_skeleton_morphology1.36146753
29MP0006138_congestive_heart_failure1.35737457
30MP0005409_darkened_coat_color1.34738551
31* MP0002128_abnormal_blood_circulation1.30414701
32MP0009278_abnormal_bone_marrow1.27951837
33MP0002254_reproductive_system_inflammat1.26309619
34MP0003950_abnormal_plasma_membrane1.25863465
35MP0005257_abnormal_intraocular_pressure1.24720204
36MP0002108_abnormal_muscle_morphology1.23125775
37MP0000343_altered_response_to1.23028090
38MP0002060_abnormal_skin_morphology1.21845844
39* MP0010630_abnormal_cardiac_muscle1.19662785
40MP0001849_ear_inflammation1.19031681
41MP0003385_abnormal_body_wall1.19022883
42MP0008004_abnormal_stomach_pH1.18376941
43MP0003303_peritoneal_inflammation1.18089692
44MP0004087_abnormal_muscle_fiber1.17317707
45MP0005076_abnormal_cell_differentiation1.16559761
46MP0001614_abnormal_blood_vessel1.16061872
47MP0002933_joint_inflammation1.15455906
48MP0009840_abnormal_foam_cell1.13951275
49MP0002168_other_aberrant_phenotype1.13764479
50MP0002009_preneoplasia1.13674484
51MP0002998_abnormal_bone_remodeling1.13325562
52MP0003724_increased_susceptibility_to1.12245147
53MP0000751_myopathy1.10760250
54MP0000003_abnormal_adipose_tissue1.10710913
55MP0008775_abnormal_heart_ventricle1.10115364
56MP0002925_abnormal_cardiovascular_devel1.10035310
57MP0005167_abnormal_blood-brain_barrier1.09769104
58MP0001243_abnormal_dermal_layer1.09634389
59MP0004036_abnormal_muscle_relaxation1.09273525
60MP0000249_abnormal_blood_vessel1.08232923
61MP0004510_myositis1.07937282
62MP0001542_abnormal_bone_strength1.07642820
63MP0009053_abnormal_anal_canal1.07568047
64MP0004883_abnormal_blood_vessel1.06315739
65MP0003453_abnormal_keratinocyte_physiol1.04635150
66MP0001533_abnormal_skeleton_physiology1.03436133
67MP0001915_intracranial_hemorrhage1.02767150
68MP0005330_cardiomyopathy1.01781918
69MP0005595_abnormal_vascular_smooth1.01491187
70MP0001544_abnormal_cardiovascular_syste1.00925753
71MP0005385_cardiovascular_system_phenoty1.00925753
72MP0003115_abnormal_respiratory_system0.99475026
73MP0000762_abnormal_tongue_morphology0.99141179
74MP0002972_abnormal_cardiac_muscle0.98614901
75MP0003448_altered_tumor_morphology0.97885499
76MP0005390_skeleton_phenotype0.97614965
77MP0009250_abnormal_appendicular_skeleto0.96843695
78MP0005388_respiratory_system_phenotype0.95398009
79MP0002133_abnormal_respiratory_system0.95398009
80MP0003191_abnormal_cellular_cholesterol0.95342385
81MP0004233_abnormal_muscle_weight0.95233562
82MP0002006_tumorigenesis0.94599449
83MP0000750_abnormal_muscle_regeneration0.93612017
84MP0004808_abnormal_hematopoietic_stem0.93309273
85MP0005670_abnormal_white_adipose0.93113233
86MP0000858_altered_metastatic_potential0.92915953
87MP0002896_abnormal_bone_mineralization0.92675280
88MP0002332_abnormal_exercise_endurance0.92362446
89MP0005367_renal/urinary_system_phenotyp0.91752519
90MP0000516_abnormal_urinary_system0.91752519
91MP0005164_abnormal_response_to0.91448587
92MP0004484_altered_response_of0.91399572
93MP0005375_adipose_tissue_phenotype0.90459143
94MP0000749_muscle_degeneration0.90354352
95MP0005058_abnormal_lysosome_morphology0.90186314
96MP0005165_increased_susceptibility_to0.88656016
97MP0005197_abnormal_uvea_morphology0.88545809
98MP0000534_abnormal_ureter_morphology0.88473945
99MP0000428_abnormal_craniofacial_morphol0.88147438
100MP0002282_abnormal_trachea_morphology0.85412868
101MP0001299_abnormal_eye_distance/0.85159931
102MP0002796_impaired_skin_barrier0.84038650
103MP0002115_abnormal_skeleton_extremities0.81244804
104MP0003941_abnormal_skin_development0.80362600
105MP0004185_abnormal_adipocyte_glucose0.80317571
106MP0005620_abnormal_muscle_contractility0.80028353
107* MP0000266_abnormal_heart_morphology0.79926720
108MP0003436_decreased_susceptibility_to0.78986837
109MP0003942_abnormal_urinary_system0.78193301
110MP0005451_abnormal_body_composition0.77768207
111MP0001175_abnormal_lung_morphology0.76755684
112MP0005621_abnormal_cell_physiology0.75711849
113MP0001348_abnormal_lacrimal_gland0.75540928
114MP0005666_abnormal_adipose_tissue0.72659564
115MP0002113_abnormal_skeleton_development0.71843388
116* MP0001784_abnormal_fluid_regulation0.71717710
117MP0004130_abnormal_muscle_cell0.70431348
118MP0000747_muscle_weakness0.70185044
119MP0000759_abnormal_skeletal_muscle0.69107288
120MP0005193_abnormal_anterior_eye0.68370010
121MP0004947_skin_inflammation0.68205792
122MP0003795_abnormal_bone_structure0.66414622
123MP0000432_abnormal_head_morphology0.66168676
124MP0002269_muscular_atrophy0.64099925

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.35066994
2Premature rupture of membranes (HP:0001788)6.11042324
3Aortic aneurysm (HP:0004942)5.04074619
4Aortic dissection (HP:0002647)4.75753633
5Shallow orbits (HP:0000586)4.63262034
6Cerebral aneurysm (HP:0004944)4.54470167
7Broad metatarsal (HP:0001783)4.50373427
8Dilatation of the ascending aorta (HP:0005111)3.82398650
9Peritonitis (HP:0002586)3.70204177
10Vascular tortuosity (HP:0004948)3.55492187
11Ankle contracture (HP:0006466)3.52165451
12Mitral valve prolapse (HP:0001634)3.31916174
13Hematochezia (HP:0002573)3.22009320
14Atrophic scars (HP:0001075)3.11982297
15Cervical subluxation (HP:0003308)3.04704841
16Arterial tortuosity (HP:0005116)3.04499831
17Soft skin (HP:0000977)3.03160024
18Bladder diverticulum (HP:0000015)3.00812900
19Osteolytic defects of the hand bones (HP:0009699)2.95630250
20Osteolytic defects of the phalanges of the hand (HP:0009771)2.95630250
21Aneurysm (HP:0002617)2.93044898
22Increased connective tissue (HP:0009025)2.90728244
23Fragile skin (HP:0001030)2.65292520
24Short nail (HP:0001799)2.59100810
25Spinal rigidity (HP:0003306)2.58351933
26Hyporeflexia of lower limbs (HP:0002600)2.57719593
27Blue sclerae (HP:0000592)2.57663457
28Wormian bones (HP:0002645)2.52308364
29Muscle fiber splitting (HP:0003555)2.50924382
30Genu recurvatum (HP:0002816)2.49742069
31Distal lower limb muscle weakness (HP:0009053)2.45594821
32Mitral regurgitation (HP:0001653)2.42736495
33Camptodactyly of toe (HP:0001836)2.41588623
34Wrist flexion contracture (HP:0001239)2.40733563
35Vertebral compression fractures (HP:0002953)2.39130504
36Thin bony cortex (HP:0002753)2.37838487
37Mesangial abnormality (HP:0001966)2.37308212
38Overgrowth (HP:0001548)2.35227218
39Spondylolisthesis (HP:0003302)2.26527385
40Mildly elevated creatine phosphokinase (HP:0008180)2.24619637
41Short 4th metacarpal (HP:0010044)2.23031261
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.23031261
43Slender build (HP:0001533)2.22038692
44Type 1 muscle fiber predominance (HP:0003803)2.21324941
45Increased density of long bones (HP:0006392)2.20185646
46Spinal cord lesions (HP:0100561)2.19747195
47Syringomyelia (HP:0003396)2.19747195
48Asymmetric septal hypertrophy (HP:0001670)2.19298497
49Distal lower limb amyotrophy (HP:0008944)2.17799896
50Pulmonary artery stenosis (HP:0004415)2.17547642
51Biconcave vertebral bodies (HP:0004586)2.17105158
52Increased variability in muscle fiber diameter (HP:0003557)2.14692560
53Abnormality of the peritoneum (HP:0002585)2.13347365
54Abnormality of the acetabulum (HP:0003170)2.12701151
55Disproportionate tall stature (HP:0001519)2.11784598
56Difficulty climbing stairs (HP:0003551)2.11588001
57Aortic regurgitation (HP:0001659)2.11145092
58Hyperextensible skin (HP:0000974)2.11127730
59Elbow flexion contracture (HP:0002987)2.10583208
60Ectopia lentis (HP:0001083)2.10470584
61Joint laxity (HP:0001388)2.08715218
62Bowel diverticulosis (HP:0005222)2.06814233
63Lymphangioma (HP:0100764)2.06779947
64Venous abnormality (HP:0002624)2.06296993
65Wide anterior fontanel (HP:0000260)2.05731180
66Venous insufficiency (HP:0005293)2.04464375
67Aortic valve stenosis (HP:0001650)2.04250496
68Ulnar bowing (HP:0003031)2.03550414
69Difficulty running (HP:0009046)2.01660493
70Polycythemia (HP:0001901)2.01635686
71Striae distensae (HP:0001065)2.01326314
72Persistence of primary teeth (HP:0006335)2.00510219
73Hypoplasia of the iris (HP:0007676)1.99378960
74Distal upper limb amyotrophy (HP:0007149)1.98274950
75Upper limb amyotrophy (HP:0009129)1.98274950
76Scapular winging (HP:0003691)1.97536081
77Abnormality of skeletal muscle fiber size (HP:0012084)1.95746138
78Nonimmune hydrops fetalis (HP:0001790)1.94995642
79Joint contractures involving the joints of the feet (HP:0100492)1.94849578
80Flexion contracture of toe (HP:0005830)1.94849578
81Absent frontal sinuses (HP:0002688)1.94711073
82Myocardial infarction (HP:0001658)1.93136150
83Follicular hyperkeratosis (HP:0007502)1.90814722
84Abnormality of dentin (HP:0010299)1.90747467
85Abnormality of the 4th metacarpal (HP:0010012)1.88552936
86Broad face (HP:0000283)1.88449472
87Joint stiffness (HP:0001387)1.88442773
88Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.88190510
89Nemaline bodies (HP:0003798)1.86508559
90Natal tooth (HP:0000695)1.85767703
91Generalized amyotrophy (HP:0003700)1.84559989
92Mitral stenosis (HP:0001718)1.84068171
93Deviation of the hallux (HP:0010051)1.83875602
94Ulnar deviation of the wrist (HP:0003049)1.83308476
95Abnormality of the nasal mucosa (HP:0000433)1.83192088
96Bicuspid aortic valve (HP:0001647)1.81885980
97Spontaneous hematomas (HP:0007420)1.80375330
98Short hallux (HP:0010109)1.79895689
99Tetraparesis (HP:0002273)1.79301865
100Delayed cranial suture closure (HP:0000270)1.79219285
101Hallux valgus (HP:0001822)1.78696126
102Neonatal short-limb short stature (HP:0008921)1.78540223
103Broad ribs (HP:0000885)1.78430841
104Narrow palate (HP:0000189)1.76961596
105Dislocated radial head (HP:0003083)1.76021960
106Buphthalmos (HP:0000557)1.75554328
107Right ventricular cardiomyopathy (HP:0011663)1.75071702
108Ovoid vertebral bodies (HP:0003300)1.73954028
109Thoracolumbar scoliosis (HP:0002944)1.73349654
110Muscle fiber inclusion bodies (HP:0100299)1.73018835
111Chondrocalcinosis (HP:0000934)1.72913003
112Abnormality of the radial head (HP:0003995)1.72362030
113Focal segmental glomerulosclerosis (HP:0000097)1.72122225
114Bowing of the arm (HP:0006488)1.71394106
115Bowed forearm bones (HP:0003956)1.71394106
116Achilles tendon contracture (HP:0001771)1.71116614
117Abnormal delivery (HP:0001787)1.70245676
118Coronal craniosynostosis (HP:0004440)1.69694445
119Knee flexion contracture (HP:0006380)1.69066948
120Radial bowing (HP:0002986)1.67841814
121Nephritis (HP:0000123)1.67751700
122Round ear (HP:0100830)1.67653285
123Thin ribs (HP:0000883)1.67313936
124Asymmetry of the thorax (HP:0001555)1.65592767
125Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.64281672
126Inguinal hernia (HP:0000023)1.62780858
127Coxa vara (HP:0002812)1.62471493
128Cardiovascular calcification (HP:0011915)1.60918226
129Abnormality of carpal bone ossification (HP:0006257)1.60721396
130Long eyelashes (HP:0000527)1.60603746
131Esophageal varix (HP:0002040)1.60124070
132Protruding ear (HP:0000411)1.59154179
133Abnormal ossification of hand bones (HP:0005921)1.57824496
134Abnormality of the phalanges of the hallux (HP:0010057)1.57028686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.63883520
2TRIB33.25565314
3TGFBR23.05202146
4TIE12.72461401
5RIPK12.64748201
6PDGFRA2.33415970
7EPHB22.23715318
8KDR2.18010822
9DMPK2.10544137
10EPHB12.09121972
11ERN11.93682607
12EPHA31.87441456
13EPHA21.86481931
14DDR21.82210413
15PRPF4B1.81868260
16LATS11.80079601
17IRAK31.75428475
18PTK2B1.73445861
19PTK61.63953433
20SIK11.63359960
21NEK91.58174161
22JAK11.56595824
23MYLK1.55735951
24PDK21.53360436
25FLT31.49976693
26STK101.49879299
27PAK21.48533949
28PRKD31.46688292
29TRPM71.45877307
30PKN21.44227753
31LRRK21.41186133
32CAMK1D1.36461709
33PTK21.35414075
34CAMK1G1.31239598
35PAK41.26910297
36PDGFRB1.25621421
37MAP3K101.25580462
38ERBB41.24567903
39TAOK21.23403708
40FGFR21.22715895
41PIK3CG1.22136035
42MUSK1.17127489
43AKT31.15168430
44FGFR31.14769711
45CDC42BPA1.14701803
46JAK31.14170524
47BRD41.13799321
48MAP3K71.12100336
49FGFR41.11120830
50TYK21.11015180
51STK31.07555058
52MAP3K61.07464011
53CSK1.07416557
54PAK31.06733919
55TESK11.02976998
56RPS6KA41.01103845
57ABL21.00525396
58SMG11.00154453
59MELK1.00139501
60GRK71.00020269
61MAP4K10.97262345
62PRKCH0.96619425
63PDK30.95914035
64PDK40.95914035
65BMX0.93365377
66LATS20.92571603
67MTOR0.92113008
68STK38L0.91348944
69MAP2K30.89800689
70CDK60.89688304
71FER0.89077598
72TGFBR10.88488583
73ROCK10.87510207
74NUAK10.85947845
75WNK10.81521094
76FRK0.81476580
77PRKD10.80815779
78KIT0.79917549
79RPS6KA20.77145611
80PIK3CA0.76949941
81MAP3K30.75442215
82MARK30.71748749
83MAPK120.71740952
84FGFR10.70739812
85PIM20.69944937
86WNK40.68899930
87INSR0.67888994
88STK240.66358959
89TBK10.65992501
90MAPK70.65582946
91EEF2K0.65321042
92MAP3K130.64570298
93NLK0.63674713
94CDK120.62370545
95ZAP700.61529023
96STK380.61489635
97MOS0.60357059
98ITK0.59912283
99TYRO30.59544797
100GSK3A0.57341841
101MST1R0.56639119
102NTRK10.56342652
103CDK90.55898239
104DAPK30.55843338
105PRKAA20.55728660
106RPS6KC10.55214038
107RPS6KL10.55214038
108MAP3K10.55164277
109HCK0.55094170
110LMTK20.54915701
111ICK0.54907074
112PRKD20.54500225
113MAP3K50.53702145
114MAP3K140.51777949
115PNCK0.51766427
116IGF1R0.50243328
117CHUK0.48434589
118ROCK20.48029953
119DYRK1B0.47773834
120MAP2K10.47091688
121SRC0.46902866
122RET0.45606978
123EGFR0.45248654
124MAP3K120.45010252
125SGK30.44252404
126MET0.43047834
127ILK0.42554433
128IRAK10.40893521
129IRAK20.40677532
130PRKG20.40526457
131IKBKB0.39280423
132MARK20.39190469
133PDPK10.38363937
134TAOK10.38132319

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.92725900
2Focal adhesion_Homo sapiens_hsa045102.64063961
3Adherens junction_Homo sapiens_hsa045202.05687981
4AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.02850687
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.95493418
6Proteoglycans in cancer_Homo sapiens_hsa052051.91226156
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.90542571
8Dilated cardiomyopathy_Homo sapiens_hsa054141.88342747
9Leukocyte transendothelial migration_Homo sapiens_hsa046701.81824057
10Small cell lung cancer_Homo sapiens_hsa052221.81441729
11Amoebiasis_Homo sapiens_hsa051461.77952644
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.74574446
13Viral myocarditis_Homo sapiens_hsa054161.73379988
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.71144043
15Other glycan degradation_Homo sapiens_hsa005111.65875736
16Osteoclast differentiation_Homo sapiens_hsa043801.44512360
17Toxoplasmosis_Homo sapiens_hsa051451.43802959
18Platelet activation_Homo sapiens_hsa046111.42085649
19Malaria_Homo sapiens_hsa051441.41971565
20Chronic myeloid leukemia_Homo sapiens_hsa052201.41520949
21Regulation of actin cytoskeleton_Homo sapiens_hsa048101.38997043
22TGF-beta signaling pathway_Homo sapiens_hsa043501.37569371
23Protein digestion and absorption_Homo sapiens_hsa049741.35070878
24MicroRNAs in cancer_Homo sapiens_hsa052061.25398501
25Pancreatic cancer_Homo sapiens_hsa052121.24054926
26Dorso-ventral axis formation_Homo sapiens_hsa043201.23400877
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22200120
28Renal cell carcinoma_Homo sapiens_hsa052111.21354277
29PI3K-Akt signaling pathway_Homo sapiens_hsa041511.17573913
30Rap1 signaling pathway_Homo sapiens_hsa040151.15804404
31Shigellosis_Homo sapiens_hsa051311.14349160
32B cell receptor signaling pathway_Homo sapiens_hsa046621.13475251
33Leishmaniasis_Homo sapiens_hsa051401.12799319
34Thyroid cancer_Homo sapiens_hsa052161.08718709
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07719942
36* Hippo signaling pathway_Homo sapiens_hsa043901.06908481
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01896293
38Pathways in cancer_Homo sapiens_hsa052001.01396595
39Prostate cancer_Homo sapiens_hsa052151.00498286
40Prion diseases_Homo sapiens_hsa050201.00127428
41Endocytosis_Homo sapiens_hsa041440.99938003
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99842244
43TNF signaling pathway_Homo sapiens_hsa046680.99188191
44p53 signaling pathway_Homo sapiens_hsa041150.98539705
45HIF-1 signaling pathway_Homo sapiens_hsa040660.96785244
46Salmonella infection_Homo sapiens_hsa051320.96595663
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94929681
48Insulin resistance_Homo sapiens_hsa049310.94707659
49Bladder cancer_Homo sapiens_hsa052190.94639309
50Glioma_Homo sapiens_hsa052140.93877518
51VEGF signaling pathway_Homo sapiens_hsa043700.93621692
52Notch signaling pathway_Homo sapiens_hsa043300.91178907
53Axon guidance_Homo sapiens_hsa043600.91097872
54Tight junction_Homo sapiens_hsa045300.89747500
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89560086
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.87139715
57Legionellosis_Homo sapiens_hsa051340.86788172
58Basal cell carcinoma_Homo sapiens_hsa052170.85491845
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.84692020
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83111338
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.82473748
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.81986410
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.81822950
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78956216
65Hepatitis C_Homo sapiens_hsa051600.78852455
66Influenza A_Homo sapiens_hsa051640.78823025
67Acute myeloid leukemia_Homo sapiens_hsa052210.78296385
68Apoptosis_Homo sapiens_hsa042100.78018036
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76586864
70HTLV-I infection_Homo sapiens_hsa051660.76145728
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.76133523
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76013111
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74817724
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73491274
75Antigen processing and presentation_Homo sapiens_hsa046120.73101521
76Hepatitis B_Homo sapiens_hsa051610.71756299
77Prolactin signaling pathway_Homo sapiens_hsa049170.71718057
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.70799529
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70168782
80African trypanosomiasis_Homo sapiens_hsa051430.68667498
81Melanoma_Homo sapiens_hsa052180.68066127
82Measles_Homo sapiens_hsa051620.67440918
83Ras signaling pathway_Homo sapiens_hsa040140.67082302
84Nitrogen metabolism_Homo sapiens_hsa009100.66692904
85FoxO signaling pathway_Homo sapiens_hsa040680.66561209
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65668915
87Insulin signaling pathway_Homo sapiens_hsa049100.65631104
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65422196
89Lysine degradation_Homo sapiens_hsa003100.65061730
90Endometrial cancer_Homo sapiens_hsa052130.65060769
91Staphylococcus aureus infection_Homo sapiens_hsa051500.65001658
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64620317
93Tuberculosis_Homo sapiens_hsa051520.63876312
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63728592
95ErbB signaling pathway_Homo sapiens_hsa040120.63624277
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63271723
97Pertussis_Homo sapiens_hsa051330.63247965
98Chemokine signaling pathway_Homo sapiens_hsa040620.63203750
99MAPK signaling pathway_Homo sapiens_hsa040100.62467208
100Complement and coagulation cascades_Homo sapiens_hsa046100.62441209
101T cell receptor signaling pathway_Homo sapiens_hsa046600.62070504
102Lysosome_Homo sapiens_hsa041420.61608133
103Hedgehog signaling pathway_Homo sapiens_hsa043400.61516457
104Hematopoietic cell lineage_Homo sapiens_hsa046400.60859555
105Estrogen signaling pathway_Homo sapiens_hsa049150.59845553
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59729802
107Sphingolipid metabolism_Homo sapiens_hsa006000.59657054
108PPAR signaling pathway_Homo sapiens_hsa033200.59531501
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.58900710
110Gap junction_Homo sapiens_hsa045400.58459465
111Melanogenesis_Homo sapiens_hsa049160.57787359
112mTOR signaling pathway_Homo sapiens_hsa041500.56849163
113Non-small cell lung cancer_Homo sapiens_hsa052230.56729723
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.56621438
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56469564
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55978813
117Colorectal cancer_Homo sapiens_hsa052100.55821326
118Viral carcinogenesis_Homo sapiens_hsa052030.54093574
119GnRH signaling pathway_Homo sapiens_hsa049120.53436416
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52997728
121Wnt signaling pathway_Homo sapiens_hsa043100.52795636
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52633801

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