LAYN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1type B pancreatic cell proliferation (GO:0044342)6.10348351
2kidney mesenchyme development (GO:0072074)5.37812510
3collagen fibril organization (GO:0030199)5.21020061
4chondrocyte proliferation (GO:0035988)5.19706364
5protein heterotrimerization (GO:0070208)4.92135784
6cell adhesion mediated by integrin (GO:0033627)4.83016755
7wound healing, spreading of epidermal cells (GO:0035313)4.70254472
8metanephric mesenchyme development (GO:0072075)4.70048535
9sequestering of extracellular ligand from receptor (GO:0035581)4.62883351
10cellular response to interferon-alpha (GO:0035457)4.58651945
11endocardial cushion development (GO:0003197)4.42092685
12endodermal cell differentiation (GO:0035987)4.31464987
13dermatan sulfate biosynthetic process (GO:0030208)4.21852718
14basement membrane organization (GO:0071711)4.12126776
15response to interferon-alpha (GO:0035455)4.10802814
16positive regulation of endothelial cell apoptotic process (GO:2000353)4.01431529
17vascular endothelial growth factor signaling pathway (GO:0038084)3.98698366
18axon extension involved in axon guidance (GO:0048846)3.87788775
19neuron projection extension involved in neuron projection guidance (GO:1902284)3.87788775
20apoptotic cell clearance (GO:0043277)3.87376698
21dermatan sulfate metabolic process (GO:0030205)3.85482094
22skin morphogenesis (GO:0043589)3.84626837
23negative regulation of smooth muscle cell migration (GO:0014912)3.83741269
24heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.81356861
25regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.75117606
26mesenchymal-epithelial cell signaling (GO:0060638)3.71923003
27wound healing, spreading of cells (GO:0044319)3.70950786
28cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.70563445
29positive regulation of natural killer cell differentiation (GO:0032825)3.70022125
30retina vasculature morphogenesis in camera-type eye (GO:0061299)3.69768358
31membrane raft organization (GO:0031579)3.69262357
32COPI coating of Golgi vesicle (GO:0048205)3.66322863
33Golgi transport vesicle coating (GO:0048200)3.66322863
34substrate-dependent cell migration (GO:0006929)3.62869699
35protein retention in ER lumen (GO:0006621)3.61858851
36collagen metabolic process (GO:0032963)3.58288129
37positive regulation of fibroblast migration (GO:0010763)3.56129352
38endothelial cell morphogenesis (GO:0001886)3.55798252
39fibril organization (GO:0097435)3.44717655
40negative regulation of osteoblast proliferation (GO:0033689)3.43968523
41collagen catabolic process (GO:0030574)3.43216090
42tooth mineralization (GO:0034505)3.38583926
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.35632707
44hypotonic response (GO:0006971)3.35586391
45detection of molecule of bacterial origin (GO:0032490)3.29924215
46multicellular organismal macromolecule metabolic process (GO:0044259)3.29710445
47actin filament depolymerization (GO:0030042)3.28540605
48endothelial cell proliferation (GO:0001935)3.26202422
49cell migration involved in sprouting angiogenesis (GO:0002042)3.26143805
50regulation of T-helper 1 cell differentiation (GO:0045625)3.24572526
51regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.21982352
52regulation of metalloenzyme activity (GO:0048552)3.20204410
53protein localization to endosome (GO:0036010)3.18584901
54muscle cell migration (GO:0014812)3.17927288
55peptidyl-proline hydroxylation (GO:0019511)3.17746772
56negative regulation of nitric-oxide synthase activity (GO:0051001)3.16528339
57negative regulation of chondrocyte differentiation (GO:0032331)3.15893633
58smooth muscle tissue development (GO:0048745)3.15176513
59negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.15114489
60hyaluronan catabolic process (GO:0030214)3.14650987
61extracellular fibril organization (GO:0043206)3.13767264
62negative regulation of axon extension involved in axon guidance (GO:0048843)3.13480744
63pericardium development (GO:0060039)3.12136045
64regulation of macrophage cytokine production (GO:0010935)3.11853024
65regulation of tight junction assembly (GO:2000810)3.10107296
66positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.10039998
67multicellular organismal catabolic process (GO:0044243)3.08795253
68substrate adhesion-dependent cell spreading (GO:0034446)3.07015336
69multicellular organismal metabolic process (GO:0044236)3.06691472
70regulation of plasminogen activation (GO:0010755)3.02980361
71cellular response to vitamin (GO:0071295)3.02686578
72protein targeting to plasma membrane (GO:0072661)3.01370971
73extracellular matrix disassembly (GO:0022617)3.01167261
74planar cell polarity pathway involved in neural tube closure (GO:0090179)3.00837542
75mesodermal cell differentiation (GO:0048333)2.99826969
76positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.99401715
77sprouting angiogenesis (GO:0002040)2.98698727
78barbed-end actin filament capping (GO:0051016)2.97030701
79cell-substrate junction assembly (GO:0007044)2.96730443
80low-density lipoprotein particle clearance (GO:0034383)2.96533039
81regulation of extracellular matrix disassembly (GO:0010715)2.96399781
82phagocytosis, recognition (GO:0006910)2.95643630
83regulation of osteoblast proliferation (GO:0033688)2.94486051
84heparan sulfate proteoglycan metabolic process (GO:0030201)2.91512214
85cell migration involved in heart development (GO:0060973)2.90367962
86adhesion of symbiont to host (GO:0044406)2.90176039
87protein maturation by protein folding (GO:0022417)2.90015608
88hemidesmosome assembly (GO:0031581)2.89572913
89negative regulation of BMP signaling pathway (GO:0030514)2.88960227
90response to fluid shear stress (GO:0034405)2.88365400
91response to gravity (GO:0009629)2.87763366
92peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.87350601
93positive regulation of epithelial to mesenchymal transition (GO:0010718)2.86954401
94middle ear morphogenesis (GO:0042474)2.86633616
95bone trabecula formation (GO:0060346)2.84738879
96positive regulation of osteoblast proliferation (GO:0033690)2.84318995
97embryonic cranial skeleton morphogenesis (GO:0048701)2.83576683
98regulation of integrin-mediated signaling pathway (GO:2001044)2.81814968
99platelet aggregation (GO:0070527)2.81114580
100regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.80329536
101protein localization to cell surface (GO:0034394)2.79174859
102response to laminar fluid shear stress (GO:0034616)2.78342402
103regulation of smooth muscle cell migration (GO:0014910)2.78126845
104positive regulation of cartilage development (GO:0061036)2.77835849
105negative regulation of stem cell proliferation (GO:2000647)2.77039064
106protein hydroxylation (GO:0018126)2.76727196
107plasma membrane repair (GO:0001778)2.76362922
108cochlea morphogenesis (GO:0090103)2.75907381
109regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.74961736
110positive regulation of interferon-alpha production (GO:0032727)2.73498686
111regulation of collagen metabolic process (GO:0010712)2.73472325
112negative regulation of embryonic development (GO:0045992)2.73335588
113outer ear morphogenesis (GO:0042473)2.73082088
114positive regulation of blood vessel endothelial cell migration (GO:0043536)2.73075870
115regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.72275866
116positive regulation of collagen biosynthetic process (GO:0032967)2.71262724
117regulation of mononuclear cell migration (GO:0071675)2.70945453
118embryonic skeletal joint morphogenesis (GO:0060272)2.70801037
119trabecula formation (GO:0060343)2.70555902
120lymphangiogenesis (GO:0001946)2.70429050
121cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.69983863
122extracellular matrix assembly (GO:0085029)2.66977861
123cellular response to vitamin D (GO:0071305)2.66608607
124regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.64943726
125negative regulation of biomineral tissue development (GO:0070168)2.61326787
126positive regulation of chemokine secretion (GO:0090197)2.60684656
127adhesion of symbiont to host cell (GO:0044650)2.60272258
128virion attachment to host cell (GO:0019062)2.60272258
129regulation of monocyte chemotaxis (GO:0090025)2.59715076
130stress fiber assembly (GO:0043149)2.59350942
131modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.58805052
132positive regulation by organism of defense response of other organism involved in symbiotic interact2.58805052
133modulation by symbiont of host immune response (GO:0052553)2.58805052
134positive regulation by symbiont of host defense response (GO:0052509)2.58805052
135modulation by symbiont of host defense response (GO:0052031)2.58805052
136modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.58805052
137regulation of interferon-beta biosynthetic process (GO:0045357)2.56973841
138platelet degranulation (GO:0002576)2.55517504
139endothelium development (GO:0003158)2.55451941
140keratan sulfate catabolic process (GO:0042340)2.53616365
141lymph vessel development (GO:0001945)2.52907329
142regulation of interferon-alpha production (GO:0032647)2.52795946
143positive regulation of chemokine biosynthetic process (GO:0045080)2.52428156
144negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.52248520
145positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.50866260
146extracellular matrix organization (GO:0030198)2.50681507
147blood vessel maturation (GO:0001955)2.50679316
148extracellular negative regulation of signal transduction (GO:1900116)2.49523819
149extracellular regulation of signal transduction (GO:1900115)2.49523819
150extracellular structure organization (GO:0043062)2.49384312
151maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.47745464

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.60485136
2RARG_19884340_ChIP-ChIP_MEFs_Mouse5.17744519
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.39776660
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.38255636
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.37600564
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.24491940
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.23914764
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.23793454
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.22418557
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.01600859
11CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse3.00640084
12RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.00151164
13CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.95369432
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.89178001
15CLOCK_20551151_ChIP-Seq_293T_Human2.80109339
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.69247913
17CJUN_26792858_Chip-Seq_BT549_Human2.65420962
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.65380076
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.55652611
20GATA2_21666600_ChIP-Seq_HMVEC_Human2.30613726
21* NRF2_20460467_ChIP-Seq_MEFs_Mouse2.30213752
22* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.30213752
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.26500528
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.23892695
25* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.22295193
26BRD4_25478319_ChIP-Seq_HGPS_Human2.17421594
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.17132147
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.13727623
29HIF1A_21447827_ChIP-Seq_MCF-7_Human2.06249648
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03404329
31EED_16625203_ChIP-ChIP_MESCs_Mouse2.03154073
32* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.00077838
33CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.96566619
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.92595022
35SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.92372622
36SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.92372622
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.89359340
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88165659
39JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.84713889
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79551054
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74277080
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72932362
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70960065
44SOX2_20726797_ChIP-Seq_SW620_Human1.69126159
45JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68689834
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62181940
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57087529
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55454690
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52040897
50HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.50904140
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49555772
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.48865273
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48417572
54SMC1_22415368_ChIP-Seq_MEFs_Mouse1.44792117
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.44308483
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39409685
57TP53_18474530_ChIP-ChIP_U2OS_Human1.36443991
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33091639
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32556539
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30949292
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29549317
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28824576
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26535205
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25238734
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23562115
66UBF1/2_26484160_Chip-Seq_HMECs_Human1.22604883
67NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.20846107
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19032730
69EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17665338
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17665338
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17487314
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17167597
73ATF3_27146783_Chip-Seq_COLON_Human1.16403667
74TP53_16413492_ChIP-PET_HCT116_Human1.16171668
75MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.14814571
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13343232
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12316516
78TFEB_21752829_ChIP-Seq_HELA_Human1.08678770
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08574800
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07450171
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07398086
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06842321
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.06776163
84VDR_24787735_ChIP-Seq_THP-1_Human1.06774602
85MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06481262
86RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06469957
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04865354
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04732502
89SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04416031
90PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.03768025
91EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.02691595
92SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02533835
93VDR_24763502_ChIP-Seq_THP-1_Human1.00896894
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00576690
95PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human1.00537983
96FOXO3_23340844_ChIP-Seq_DLD1_Human1.00181367
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.00150171
98TP53_22127205_ChIP-Seq_IMR90_Human0.99860032
99P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99576129
100CSB_26484114_Chip-Seq_FIBROBLAST_Human0.99413228
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98045061
102ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97514397
103SA1_22415368_ChIP-Seq_MEFs_Mouse0.96654840
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96424785
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95516941
106RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95061640
107TP53_23651856_ChIP-Seq_MEFs_Mouse0.94091433
108SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93423978
109NFI_21473784_ChIP-Seq_ESCs_Mouse0.93221904
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92824833
111STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92757180
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92502706
113KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91355883
114EOMES_21245162_ChIP-Seq_HESCs_Human0.90973235
115ESR2_21235772_ChIP-Seq_MCF-7_Human0.90761159
116* TET1_21490601_ChIP-Seq_MESCs_Mouse0.89756028
117NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89372863
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.88395182
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.88395182
120* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87268584
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86967443
122SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86787221
123STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86766396
124TP53_20018659_ChIP-ChIP_R1E_Mouse0.86753995
125SPI1_23547873_ChIP-Seq_NB4_Human0.86531278
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85371252
127KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85302074
128* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83929841
129RACK7_27058665_Chip-Seq_MCF-7_Human0.83777102
130SPI1_23127762_ChIP-Seq_K562_Human0.83386861
131JARID2_20075857_ChIP-Seq_MESCs_Mouse0.83385071
132PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82066291
133FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81491840
134STAT6_21828071_ChIP-Seq_BEAS2B_Human0.81407347
135TP63_23658742_ChIP-Seq_EP156T_Human0.80848067
136GATA4_21415370_ChIP-Seq_HL-1_Mouse0.76766630

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.83396514
2MP0003705_abnormal_hypodermis_morpholog5.03821173
3MP0003279_aneurysm4.36441513
4MP0005503_abnormal_tendon_morphology4.32852957
5MP0005275_abnormal_skin_tensile4.26629354
6MP0001958_emphysema3.38956254
7MP0006054_spinal_hemorrhage2.76571733
8MP0004272_abnormal_basement_membrane2.61818290
9MP0010368_abnormal_lymphatic_system2.54466112
10MP0009384_cardiac_valve_regurgitation2.53807847
11MP0005623_abnormal_meninges_morphology2.21881008
12MP0003724_increased_susceptibility_to2.19291974
13MP0005023_abnormal_wound_healing2.14091953
14MP0003091_abnormal_cell_migration2.11425655
15MP0003566_abnormal_cell_adhesion2.10728482
16MP0001879_abnormal_lymphatic_vessel2.07082346
17MP0001542_abnormal_bone_strength1.95024628
18MP0003950_abnormal_plasma_membrane1.85460516
19MP0005508_abnormal_skeleton_morphology1.73406161
20MP0000751_myopathy1.71335580
21MP0010352_gastrointestinal_tract_polyps1.65567937
22MP0002295_abnormal_pulmonary_circulatio1.64467408
23MP0000767_abnormal_smooth_muscle1.63969682
24MP0002060_abnormal_skin_morphology1.63392364
25MP0001533_abnormal_skeleton_physiology1.60088617
26MP0000534_abnormal_ureter_morphology1.59193975
27MP0003941_abnormal_skin_development1.57189252
28MP0003828_pulmonary_edema1.56910404
29MP0001348_abnormal_lacrimal_gland1.53349579
30MP0010386_abnormal_urinary_bladder1.51937629
31MP0005390_skeleton_phenotype1.46724607
32MP0000343_altered_response_to1.46080696
33MP0009780_abnormal_chondrocyte_physiolo1.44558686
34MP0002877_abnormal_melanocyte_morpholog1.41160033
35MP0005164_abnormal_response_to1.39367257
36MP0004883_abnormal_blood_vessel1.36153805
37MP0003942_abnormal_urinary_system1.35700204
38MP0009278_abnormal_bone_marrow1.34735717
39MP0005257_abnormal_intraocular_pressure1.30660839
40MP0002933_joint_inflammation1.26633084
41MP0000749_muscle_degeneration1.24735017
42MP0005058_abnormal_lysosome_morphology1.24424239
43MP0002998_abnormal_bone_remodeling1.23460712
44MP0003300_gastrointestinal_ulcer1.23169961
45MP0000733_abnormal_muscle_development1.20853919
46MP0003448_altered_tumor_morphology1.19812867
47MP0009053_abnormal_anal_canal1.18153832
48MP0001243_abnormal_dermal_layer1.15854839
49MP0005171_absent_coat_pigmentation1.11795702
50MP0002896_abnormal_bone_mineralization1.11432249
51MP0002108_abnormal_muscle_morphology1.08687397
52MP0000249_abnormal_blood_vessel1.08310125
53MP0004808_abnormal_hematopoietic_stem1.07612939
54MP0003303_peritoneal_inflammation1.05857409
55MP0003436_decreased_susceptibility_to1.05049240
56MP0000858_altered_metastatic_potential1.04840495
57MP0005595_abnormal_vascular_smooth1.04776091
58MP0009785_altered_susceptibility_to1.04719543
59MP0000013_abnormal_adipose_tissue1.02533708
60MP0002148_abnormal_hypersensitivity_rea1.02451564
61MP0001915_intracranial_hemorrhage1.01653083
62MP0000759_abnormal_skeletal_muscle1.01280555
63MP0002419_abnormal_innate_immunity0.99447943
64MP0003045_fibrosis0.97398126
65MP0000428_abnormal_craniofacial_morphol0.96246114
66MP0002168_other_aberrant_phenotype0.95554919
67MP0010030_abnormal_orbit_morphology0.95337803
68MP0004858_abnormal_nervous_system0.95195155
69MP0005397_hematopoietic_system_phenotyp0.94748177
70MP0001545_abnormal_hematopoietic_system0.94748177
71MP0009250_abnormal_appendicular_skeleto0.92870098
72MP0003283_abnormal_digestive_organ0.91964830
73MP0002128_abnormal_blood_circulation0.91855733
74MP0001614_abnormal_blood_vessel0.89709033
75MP0006082_CNS_inflammation0.89442633
76MP0000762_abnormal_tongue_morphology0.89212495
77MP0001849_ear_inflammation0.88090647
78MP0000003_abnormal_adipose_tissue0.87782358
79MP0003795_abnormal_bone_structure0.87507789
80MP0002115_abnormal_skeleton_extremities0.86878947
81MP0005165_increased_susceptibility_to0.85906896
82MP0003385_abnormal_body_wall0.85567672
83MP0002113_abnormal_skeleton_development0.84659483
84MP0005197_abnormal_uvea_morphology0.83847430
85MP0000538_abnormal_urinary_bladder0.82819754
86MP0005388_respiratory_system_phenotype0.81550144
87MP0002133_abnormal_respiratory_system0.81550144
88MP0002254_reproductive_system_inflammat0.81389056
89MP0005167_abnormal_blood-brain_barrier0.80736378
90MP0000049_abnormal_middle_ear0.80703388
91MP0000163_abnormal_cartilage_morphology0.80305475
92MP0004134_abnormal_chest_morphology0.79885952
93MP0002177_abnormal_outer_ear0.78691766
94MP0003075_altered_response_to0.78550933
95MP0000750_abnormal_muscle_regeneration0.75047767
96MP0005464_abnormal_platelet_physiology0.74103287
97MP0001299_abnormal_eye_distance/0.72670095
98MP0000432_abnormal_head_morphology0.72295639
99MP0001853_heart_inflammation0.71540036
100MP0000569_abnormal_digit_pigmentation0.71154637
101MP0001175_abnormal_lung_morphology0.70388956
102MP0002282_abnormal_trachea_morphology0.69710387
103MP0005000_abnormal_immune_tolerance0.69257073
104MP0003191_abnormal_cellular_cholesterol0.67958079
105MP0009764_decreased_sensitivity_to0.66767434
106MP0002332_abnormal_exercise_endurance0.65139366
107MP0002396_abnormal_hematopoietic_system0.64107486
108MP0008007_abnormal_cellular_replicative0.63662671
109MP0002006_tumorigenesis0.62771777
110MP0004233_abnormal_muscle_weight0.61214119
111MP0002925_abnormal_cardiovascular_devel0.61145605
112MP0002405_respiratory_system_inflammati0.60669398
113MP0003755_abnormal_palate_morphology0.60337404
114MP0002166_altered_tumor_susceptibility0.60100377
115MP0004947_skin_inflammation0.59035029
116MP0002932_abnormal_joint_morphology0.59034544
117MP0005193_abnormal_anterior_eye0.58793161
118MP0010307_abnormal_tumor_latency0.58098335
119MP0001270_distended_abdomen0.57873059
120MP0008004_abnormal_stomach_pH0.57831628
121MP0009840_abnormal_foam_cell0.57738655
122MP0005620_abnormal_muscle_contractility0.56354598
123MP0002114_abnormal_axial_skeleton0.56072993
124MP0000685_abnormal_immune_system0.55613294
125MP0002109_abnormal_limb_morphology0.55069351
126MP0000462_abnormal_digestive_system0.54984111
127MP0002452_abnormal_antigen_presenting0.54958547
128MP0000681_abnormal_thyroid_gland0.54762717
129MP0009379_abnormal_foot_pigmentation0.54207507
130MP0003937_abnormal_limbs/digits/tail_de0.54098931
131MP0005025_abnormal_response_to0.54055350
132MP0004084_abnormal_cardiac_muscle0.53396659
133MP0002269_muscular_atrophy0.52901299
134MP0008775_abnormal_heart_ventricle0.52599552
135MP0003115_abnormal_respiratory_system0.51330451
136MP0002116_abnormal_craniofacial_bone0.50547940
137MP0005369_muscle_phenotype0.46340415
138MP0003935_abnormal_craniofacial_develop0.42181052
139MP0004036_abnormal_muscle_relaxation0.41051925

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.91400423
2Premature rupture of membranes (HP:0001788)7.84740876
3Vertebral compression fractures (HP:0002953)5.17096021
4Aortic dissection (HP:0002647)4.72000575
5Aortic aneurysm (HP:0004942)4.60761862
6Peritonitis (HP:0002586)4.56522064
7Soft skin (HP:0000977)4.53049590
8Ankle contracture (HP:0006466)4.45875831
9Shallow orbits (HP:0000586)4.37624280
10Cerebral aneurysm (HP:0004944)4.18361782
11Dilatation of the ascending aorta (HP:0005111)4.03557068
12Spinal rigidity (HP:0003306)3.92509960
13Abnormality of dentin (HP:0010299)3.89182568
14Biconcave vertebral bodies (HP:0004586)3.86683958
15Vascular tortuosity (HP:0004948)3.67765559
16Fragile skin (HP:0001030)3.60905765
17Wormian bones (HP:0002645)3.58905202
18Atrophic scars (HP:0001075)3.58811655
19Bladder diverticulum (HP:0000015)3.52127397
20Cervical subluxation (HP:0003308)3.50240685
21Broad metatarsal (HP:0001783)3.43178341
22Arterial tortuosity (HP:0005116)3.30099928
23Follicular hyperkeratosis (HP:0007502)3.27928444
24Wrist flexion contracture (HP:0001239)3.22425755
25Blue sclerae (HP:0000592)3.13373767
26Genu recurvatum (HP:0002816)3.10790510
27Osteolytic defects of the phalanges of the hand (HP:0009771)3.07573246
28Osteolytic defects of the hand bones (HP:0009699)3.07573246
29Type 1 muscle fiber predominance (HP:0003803)2.98082819
30Spondylolisthesis (HP:0003302)2.95845273
31Increased connective tissue (HP:0009025)2.95637272
32Overgrowth (HP:0001548)2.92302379
33Mitral valve prolapse (HP:0001634)2.73909710
34Neonatal short-limb short stature (HP:0008921)2.72744828
35Spinal cord lesions (HP:0100561)2.71753459
36Syringomyelia (HP:0003396)2.71753459
37Short nail (HP:0001799)2.68559147
38Abnormality of the acetabulum (HP:0003170)2.65056876
39Abnormal delivery (HP:0001787)2.63111083
40Slender build (HP:0001533)2.62559849
41Nonimmune hydrops fetalis (HP:0001790)2.62520167
42Ulnar bowing (HP:0003031)2.59435061
43Joint stiffness (HP:0001387)2.58790914
44Hypoventilation (HP:0002791)2.51836391
45Coxa vara (HP:0002812)2.46926084
46Hyperextensible skin (HP:0000974)2.44038763
47Elbow flexion contracture (HP:0002987)2.40442562
48Aneurysm (HP:0002617)2.39484746
49Beaking of vertebral bodies (HP:0004568)2.37838360
50Bowel diverticulosis (HP:0005222)2.34253902
51Long toe (HP:0010511)2.32688614
52Entropion (HP:0000621)2.31727948
53Increased density of long bones (HP:0006392)2.30385777
54Absent frontal sinuses (HP:0002688)2.27031117
55Camptodactyly of toe (HP:0001836)2.24218659
56Redundant skin (HP:0001582)2.21121816
57Abnormality of the peritoneum (HP:0002585)2.19237750
58Hematochezia (HP:0002573)2.17825848
59Mild short stature (HP:0003502)2.13844337
60Joint laxity (HP:0001388)2.08187878
61Increased cerebral lipofuscin (HP:0011813)2.07843506
62Elevated erythrocyte sedimentation rate (HP:0003565)2.07431770
63Ovoid vertebral bodies (HP:0003300)2.06954713
64Cardiovascular calcification (HP:0011915)2.06103485
65Ectopia lentis (HP:0001083)2.05162719
66Protruding ear (HP:0000411)2.05124007
67Natal tooth (HP:0000695)2.04080373
68Venous abnormality (HP:0002624)2.03898532
69Mitral regurgitation (HP:0001653)2.03658637
70Abnormality of skull ossification (HP:0002703)2.01581266
71Bowed forearm bones (HP:0003956)2.00516230
72Bowing of the arm (HP:0006488)2.00516230
73Mitral stenosis (HP:0001718)2.00213849
74Delayed gross motor development (HP:0002194)1.99373231
75Mildly elevated creatine phosphokinase (HP:0008180)1.98712632
76Dysostosis multiplex (HP:0000943)1.98063009
77Bradycardia (HP:0001662)1.97400488
78Round ear (HP:0100830)1.96596246
79Increased neuronal autofluorescent lipopigment (HP:0002074)1.95629538
80Osteopenia (HP:0000938)1.95346283
81Increased variability in muscle fiber diameter (HP:0003557)1.94627888
82Disproportionate tall stature (HP:0001519)1.94537711
83Abnormality of skeletal muscle fiber size (HP:0012084)1.94472775
84Glucose intolerance (HP:0000833)1.94389573
85Striae distensae (HP:0001065)1.93726215
86Reduced subcutaneous adipose tissue (HP:0003758)1.92285942
87Joint contractures involving the joints of the feet (HP:0100492)1.91943906
88Flexion contracture of toe (HP:0005830)1.91943906
89Distal lower limb amyotrophy (HP:0008944)1.91807388
90Limb-girdle muscle weakness (HP:0003325)1.90779687
91Myositis (HP:0100614)1.90496792
92Venous insufficiency (HP:0005293)1.90277250
93Generalized amyotrophy (HP:0003700)1.89028424
94Delayed cranial suture closure (HP:0000270)1.86957183
95Inguinal hernia (HP:0000023)1.86389013
96Flared iliac wings (HP:0002869)1.86331463
97Distal upper limb amyotrophy (HP:0007149)1.84876550
98Upper limb amyotrophy (HP:0009129)1.84876550
99Delayed closure of the anterior fontanelle (HP:0001476)1.82943618
100Thin bony cortex (HP:0002753)1.79920794
101Deviation of the hallux (HP:0010051)1.79112642
102Achilles tendon contracture (HP:0001771)1.77987870
103Decreased skull ossification (HP:0004331)1.77678485
104Abnormality of the pericardium (HP:0001697)1.75721766
105Ulnar deviation of the wrist (HP:0003049)1.74936667
106Radial bowing (HP:0002986)1.74596277
107Breech presentation (HP:0001623)1.73170070
108Premature skin wrinkling (HP:0100678)1.72664267
109Thoracolumbar scoliosis (HP:0002944)1.72231839
110Broad ribs (HP:0000885)1.71908938
111Bruising susceptibility (HP:0000978)1.71754768
112Aortic valve stenosis (HP:0001650)1.70148675
113Wide anterior fontanel (HP:0000260)1.69868888
114Myocardial infarction (HP:0001658)1.69841221
115Hallux valgus (HP:0001822)1.68388756
116Hand muscle atrophy (HP:0009130)1.67619916
117Orchitis (HP:0100796)1.67394419
118Acrocyanosis (HP:0001063)1.66629356
119Coronal craniosynostosis (HP:0004440)1.66578966
120Mesomelia (HP:0003027)1.65660708
121Persistence of primary teeth (HP:0006335)1.65502454
122Aortic regurgitation (HP:0001659)1.64507488
123Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.64471983
124Infantile muscular hypotonia (HP:0008947)1.64424602

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR23.28239190
2TIE13.24748534
3TRPM72.87994190
4TTN2.84162469
5PIM22.75370908
6ERN12.73986381
7TRIB32.56211765
8LATS22.55981163
9NME22.45497091
10NEK92.36984576
11TGFBR22.29573156
12TESK12.24058565
13PDGFRA2.08951059
14RPS6KA42.00847321
15PKN21.97407424
16MOS1.89381863
17AKT31.87022202
18BLK1.86713825
19LIMK11.85779449
20PTK2B1.85750456
21STK381.83540184
22PRKD21.79386517
23TGFBR11.78084698
24BMX1.77468035
25PAK21.76682414
26KDR1.74147327
27GRK71.71721526
28ERBB31.63574219
29KIT1.59234533
30PAK41.57014411
31TBK11.55007571
32MET1.54646750
33LRRK21.53787983
34PAK61.42960445
35FER1.37965269
36PBK1.35521462
37EPHA21.35391064
38CDC42BPA1.33278671
39SIK11.33258656
40EPHB21.28943412
41IRAK31.28346342
42EIF2AK11.25534158
43ERBB41.22029607
44MAP3K121.19834876
45FLT31.17556835
46CAMKK21.16630478
47PAK31.15926000
48MYLK1.15580711
49MAP2K31.15017417
50TESK21.11163663
51PIK3CA1.08185874
52TYK21.07842089
53PTK21.06529586
54PTK61.05009368
55PIK3CG1.04372160
56STK101.01425396
57ABL21.01213427
58STK30.99745382
59TEC0.99187267
60MAPKAPK50.98132633
61JAK30.95666293
62GRK50.95551256
63PLK20.95247169
64NUAK10.92108106
65EPHA30.89669714
66MAPKAPK30.89607044
67EPHB10.86039378
68LATS10.85687488
69PDK20.85441493
70ILK0.84632412
71TXK0.84008698
72JAK10.79388471
73MAP2K10.78036523
74EEF2K0.77973942
75RIPK10.74183148
76DMPK0.74081369
77SCYL20.73525156
78CAMK1D0.71420428
79RPS6KA20.71175127
80CAMK2G0.70392401
81ROCK10.68119653
82MAP3K130.67836283
83MAP3K140.67153235
84BUB10.66608350
85CDK60.66115495
86GSK3A0.65579066
87ADRBK20.63548609
88PRKG20.62781250
89PDGFRB0.62093708
90IKBKB0.61474581
91CAMKK10.60756129
92PAK10.59823530
93MTOR0.59298898
94MELK0.59037322
95INSR0.58728092
96GRK10.57684039
97MAP3K60.56604337
98NTRK10.55258268
99DAPK30.54333849
100MARK30.52552299
101MATK0.51560146
102PRKCE0.49982148
103STK38L0.49130197
104HCK0.47973970
105ABL10.47680972
106MAPK70.46983062
107WNK10.46761187
108PRKD30.46457419
109SRC0.42230631
110ROCK20.40711603
111ZAP700.40389946
112CSF1R0.39699107
113PRKD10.38580848
114EIF2AK20.38371999
115MAPK110.38012468
116IGF1R0.36421000
117VRK20.35448000
118MAPKAPK20.35394787
119FRK0.34642558
120EGFR0.32692033
121MAP3K30.32666101
122CAMK2D0.32468956
123EIF2AK30.32123557
124TAOK20.31878720
125ARAF0.31800526
126ZAK0.31599571
127MAP2K60.31069165
128CDK80.30660500
129ADRBK10.30048072
130FGFR10.29047895
131CDK90.27717918
132SMG10.26772107
133ICK0.26017831
134MST1R0.25470886
135NEK20.20138364
136AURKA0.19140920
137PRKCH0.18636697

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051443.06953284
2ECM-receptor interaction_Homo sapiens_hsa045122.87584659
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.74058952
4Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.55108843
5Focal adhesion_Homo sapiens_hsa045102.46863065
6AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.20611333
7Leishmaniasis_Homo sapiens_hsa051402.15385240
8Amoebiasis_Homo sapiens_hsa051462.00869539
9Proteoglycans in cancer_Homo sapiens_hsa052051.98700674
10Shigellosis_Homo sapiens_hsa051311.92817729
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.89574108
12Pertussis_Homo sapiens_hsa051331.86347070
13Rheumatoid arthritis_Homo sapiens_hsa053231.84745578
14Phagosome_Homo sapiens_hsa041451.80021332
15Adherens junction_Homo sapiens_hsa045201.77356085
16Salmonella infection_Homo sapiens_hsa051321.75548774
17TNF signaling pathway_Homo sapiens_hsa046681.73544176
18Legionellosis_Homo sapiens_hsa051341.69319419
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67397154
20Viral myocarditis_Homo sapiens_hsa054161.66931234
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.59893682
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.59610144
23Osteoclast differentiation_Homo sapiens_hsa043801.53000671
24Hedgehog signaling pathway_Homo sapiens_hsa043401.49193252
25Lysosome_Homo sapiens_hsa041421.49002009
26Small cell lung cancer_Homo sapiens_hsa052221.46575075
27Toxoplasmosis_Homo sapiens_hsa051451.46015825
28Platelet activation_Homo sapiens_hsa046111.44093086
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.43732268
30Dilated cardiomyopathy_Homo sapiens_hsa054141.39470260
31HIF-1 signaling pathway_Homo sapiens_hsa040661.38623653
32Tuberculosis_Homo sapiens_hsa051521.37871151
33TGF-beta signaling pathway_Homo sapiens_hsa043501.36503861
34Chronic myeloid leukemia_Homo sapiens_hsa052201.35955366
35Apoptosis_Homo sapiens_hsa042101.30542522
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28597519
37Basal cell carcinoma_Homo sapiens_hsa052171.27872131
38PI3K-Akt signaling pathway_Homo sapiens_hsa041511.26219837
39Sulfur metabolism_Homo sapiens_hsa009201.23782442
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.22347587
41MicroRNAs in cancer_Homo sapiens_hsa052061.21492167
42Other glycan degradation_Homo sapiens_hsa005111.20739422
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18935335
44Melanoma_Homo sapiens_hsa052181.17802375
45Bladder cancer_Homo sapiens_hsa052191.16971854
46Caffeine metabolism_Homo sapiens_hsa002321.15748513
47Staphylococcus aureus infection_Homo sapiens_hsa051501.10046374
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09650876
49Hepatitis B_Homo sapiens_hsa051611.08718335
50p53 signaling pathway_Homo sapiens_hsa041151.02546440
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02156376
52Pancreatic cancer_Homo sapiens_hsa052121.01337165
53Measles_Homo sapiens_hsa051620.99721510
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.99294518
55Hematopoietic cell lineage_Homo sapiens_hsa046400.96027165
56Rap1 signaling pathway_Homo sapiens_hsa040150.95654119
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93061207
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92790428
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92039621
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89969463
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89930204
62Protein digestion and absorption_Homo sapiens_hsa049740.89352745
63Proteasome_Homo sapiens_hsa030500.87456644
64Influenza A_Homo sapiens_hsa051640.87283472
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.85408704
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84953022
67Antigen processing and presentation_Homo sapiens_hsa046120.83746042
68HTLV-I infection_Homo sapiens_hsa051660.83429782
69Tight junction_Homo sapiens_hsa045300.83300679
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82904053
71Galactose metabolism_Homo sapiens_hsa000520.81997490
72Glioma_Homo sapiens_hsa052140.80608826
73Melanogenesis_Homo sapiens_hsa049160.79701687
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75196998
75Allograft rejection_Homo sapiens_hsa053300.73738202
76Axon guidance_Homo sapiens_hsa043600.72816984
77Sphingolipid metabolism_Homo sapiens_hsa006000.72725076
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72409731
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72012915
80Prostate cancer_Homo sapiens_hsa052150.71835735
81Nucleotide excision repair_Homo sapiens_hsa034200.71477506
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71427647
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.70049713
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.67944168
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67762841
86Endocytosis_Homo sapiens_hsa041440.67079204
87African trypanosomiasis_Homo sapiens_hsa051430.66905759
88Wnt signaling pathway_Homo sapiens_hsa043100.66827932
89Pathways in cancer_Homo sapiens_hsa052000.66690107
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.66298791
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65296572
92Graft-versus-host disease_Homo sapiens_hsa053320.64916326
93Gap junction_Homo sapiens_hsa045400.64795385
94Viral carcinogenesis_Homo sapiens_hsa052030.62035998
95VEGF signaling pathway_Homo sapiens_hsa043700.60084399
96Chemokine signaling pathway_Homo sapiens_hsa040620.58434395
97Ovarian steroidogenesis_Homo sapiens_hsa049130.57661418
98Prion diseases_Homo sapiens_hsa050200.57602139
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57552092
100Complement and coagulation cascades_Homo sapiens_hsa046100.56110083
101Hepatitis C_Homo sapiens_hsa051600.55940499
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54637296
103B cell receptor signaling pathway_Homo sapiens_hsa046620.54146536
104Glutathione metabolism_Homo sapiens_hsa004800.53887483
105Acute myeloid leukemia_Homo sapiens_hsa052210.52387596
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.52095352
107Sulfur relay system_Homo sapiens_hsa041220.51974615
108Hippo signaling pathway_Homo sapiens_hsa043900.50736520
109Ras signaling pathway_Homo sapiens_hsa040140.50026711
110Folate biosynthesis_Homo sapiens_hsa007900.49829950
111N-Glycan biosynthesis_Homo sapiens_hsa005100.49800531
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49645816
113Thyroid cancer_Homo sapiens_hsa052160.49481577
114MAPK signaling pathway_Homo sapiens_hsa040100.49350849
115Vibrio cholerae infection_Homo sapiens_hsa051100.48123289
116Colorectal cancer_Homo sapiens_hsa052100.47469914
117Renal cell carcinoma_Homo sapiens_hsa052110.47146851
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47133740
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.46770918
120Renin-angiotensin system_Homo sapiens_hsa046140.45603897
121Selenocompound metabolism_Homo sapiens_hsa004500.43857295
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42869699
123Herpes simplex infection_Homo sapiens_hsa051680.42419394
124Pyrimidine metabolism_Homo sapiens_hsa002400.42155625
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41415786
126Salivary secretion_Homo sapiens_hsa049700.40506525
127Calcium signaling pathway_Homo sapiens_hsa040200.39946070
128Pentose phosphate pathway_Homo sapiens_hsa000300.37965132
129Cocaine addiction_Homo sapiens_hsa050300.35364502
130Thyroid hormone synthesis_Homo sapiens_hsa049180.28109550
131One carbon pool by folate_Homo sapiens_hsa006700.26316243
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25065875
133GnRH signaling pathway_Homo sapiens_hsa049120.24090075
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24058062
135cAMP signaling pathway_Homo sapiens_hsa040240.21433879

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