LBH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)8.00643202
2sarcomere organization (GO:0045214)7.81657838
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.45192101
4negative regulation of potassium ion transmembrane transport (GO:1901380)7.09433895
5myofibril assembly (GO:0030239)6.64280974
6regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.99603185
7cardiac muscle contraction (GO:0060048)5.91242370
8negative regulation of cell killing (GO:0031342)5.79982840
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.79982840
10cardiac muscle cell development (GO:0055013)5.59446253
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.38693968
12regulation of actin filament-based movement (GO:1903115)5.35001383
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.32283211
14cardiac cell development (GO:0055006)5.28683721
15regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.24374700
16plasma membrane repair (GO:0001778)5.23848910
17adult heart development (GO:0007512)5.23257707
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.16127687
19actin-myosin filament sliding (GO:0033275)5.15143290
20muscle filament sliding (GO:0030049)5.15143290
21ventricular cardiac muscle cell action potential (GO:0086005)5.12964252
22actomyosin structure organization (GO:0031032)5.09958775
23regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.07264937
24positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.05422839
25heart trabecula formation (GO:0060347)4.99347505
26ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.95633116
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.89009961
28regulation of relaxation of muscle (GO:1901077)4.87662525
29regulation of sarcomere organization (GO:0060297)4.81829650
30cardiac muscle tissue morphogenesis (GO:0055008)4.81694181
31cardiac muscle hypertrophy (GO:0003300)4.80241421
32bundle of His cell to Purkinje myocyte communication (GO:0086069)4.80050802
33antigen processing and presentation of endogenous antigen (GO:0019883)4.79246476
34positive regulation of gamma-delta T cell activation (GO:0046645)4.76159408
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.70660968
36negative T cell selection (GO:0043383)4.59165753
37regulation of the force of heart contraction (GO:0002026)4.54284306
38striated muscle hypertrophy (GO:0014897)4.51548396
39tricarboxylic acid cycle (GO:0006099)4.46845226
40negative thymic T cell selection (GO:0045060)4.43502362
41cell communication involved in cardiac conduction (GO:0086065)4.40046385
42regulation of striated muscle contraction (GO:0006942)4.34893462
43actin-mediated cell contraction (GO:0070252)4.30741634
44cell communication by electrical coupling (GO:0010644)4.29912648
45response to interleukin-15 (GO:0070672)4.28175663
46muscle tissue morphogenesis (GO:0060415)4.27293585
47positive T cell selection (GO:0043368)4.26946035
48striated muscle contraction (GO:0006941)4.17861904
49cellular response to interleukin-15 (GO:0071350)4.17684157
50regulation of membrane repolarization (GO:0060306)4.14646113
51regulation of cardioblast differentiation (GO:0051890)4.14560059
52regulation of B cell receptor signaling pathway (GO:0050855)4.10257129
53regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.08099378
54negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.07784847
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.00051775
56regulation of cardiac muscle cell contraction (GO:0086004)3.99968200
57muscle hypertrophy (GO:0014896)3.97520015
58thymic T cell selection (GO:0045061)3.94471034
59relaxation of cardiac muscle (GO:0055119)3.91832928
60regulation of T cell tolerance induction (GO:0002664)3.86655371
61regulation of cardiac muscle contraction (GO:0055117)3.83709815
62leukocyte aggregation (GO:0070486)3.83236983
63negative regulation of potassium ion transport (GO:0043267)3.82816074
64activated T cell proliferation (GO:0050798)3.80066208
65cardiac muscle adaptation (GO:0014887)3.79359199
66cardiac muscle hypertrophy in response to stress (GO:0014898)3.79359199
67muscle hypertrophy in response to stress (GO:0003299)3.79359199
68T cell selection (GO:0045058)3.75096519
69carnitine shuttle (GO:0006853)3.74270877
70regulation of cell communication by electrical coupling (GO:0010649)3.72969698
71actin filament-based movement (GO:0030048)3.65033289
72regulation of skeletal muscle contraction (GO:0014819)3.62544451
73negative regulation of striated muscle cell apoptotic process (GO:0010664)3.61807896
74atrial septum morphogenesis (GO:0060413)3.58701816
75regulation of heart rate (GO:0002027)3.54682127
76regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.49427985
77membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.48644423
78regulation of gamma-delta T cell differentiation (GO:0045586)3.47401217
79potassium ion export (GO:0071435)3.46341952
80trabecula formation (GO:0060343)3.42466703
81heart process (GO:0003015)3.40693774
82heart contraction (GO:0060047)3.40693774
83cardiac muscle cell action potential involved in contraction (GO:0086002)3.40391069
84positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.38154085
85venous blood vessel morphogenesis (GO:0048845)3.37625568
86regulation of heart contraction (GO:0008016)3.37132636
87cardiac muscle cell action potential (GO:0086001)3.33853477
88ventricular cardiac muscle cell development (GO:0055015)3.33823230
89regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.26859392
90regulation of natural killer cell mediated immunity (GO:0002715)3.26859392
91cardiac chamber formation (GO:0003207)3.26451506
92regulation of gamma-delta T cell activation (GO:0046643)3.25769220
93positive regulation of tolerance induction (GO:0002645)3.25018453
94sarcoplasmic reticulum calcium ion transport (GO:0070296)3.23957421
95cardiac conduction (GO:0061337)3.23621307
96regulation of regulatory T cell differentiation (GO:0045589)3.22923436
97regulation of tolerance induction (GO:0002643)3.21793759
98tolerance induction (GO:0002507)3.20261698
99T cell migration (GO:0072678)3.18987435
100negative regulation of lymphocyte mediated immunity (GO:0002707)3.18882000
101blood vessel maturation (GO:0001955)3.16687924
102cell migration involved in heart development (GO:0060973)3.15820909
103regulation of ATP catabolic process (GO:1903289)3.14728103
104regulation of ATPase activity (GO:0043462)3.14728103
105B cell receptor signaling pathway (GO:0050853)3.13367582
106positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.12306332
107regulation of heart rate by cardiac conduction (GO:0086091)3.11890936
108fatty acid transmembrane transport (GO:1902001)3.11619612
109negative regulation of cell size (GO:0045792)3.10766998
110membrane repolarization during action potential (GO:0086011)3.09822636
111positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.07698615
112positive thymic T cell selection (GO:0045059)3.07307220
113regulation of acyl-CoA biosynthetic process (GO:0050812)3.05712594
114negative regulation of cardiac muscle tissue growth (GO:0055022)3.05246892
115negative regulation of heart growth (GO:0061117)3.05246892
116NIK/NF-kappaB signaling (GO:0038061)3.04596239
117negative regulation of T cell mediated immunity (GO:0002710)3.02520955
118oxygen transport (GO:0015671)3.01655218
119positive regulation of heart contraction (GO:0045823)3.00999250
120negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.00590222
121regulation of muscle contraction (GO:0006937)2.98165964
122positive regulation of cation channel activity (GO:2001259)2.97666074
123negative regulation of cytosolic calcium ion concentration (GO:0051481)2.96860851
124cardiac muscle cell proliferation (GO:0060038)2.96321407
125positive regulation of granulocyte differentiation (GO:0030854)2.95343857
126regulation of isotype switching to IgG isotypes (GO:0048302)2.94702220
127regulation of B cell differentiation (GO:0045577)2.94654096
128striated muscle cell development (GO:0055002)2.93571404
129vascular endothelial growth factor signaling pathway (GO:0038084)2.91909233
130positive regulation of natural killer cell differentiation (GO:0032825)2.90913407
131negative regulation of leukocyte mediated immunity (GO:0002704)2.89321607
132positive regulation of potassium ion transmembrane transport (GO:1901381)2.88317667
133regulation of T cell mediated cytotoxicity (GO:0001914)2.88099220
134negative regulation of protein localization to cell surface (GO:2000009)2.87599479
135outflow tract septum morphogenesis (GO:0003148)2.86102791
136regulation of tight junction assembly (GO:2000810)2.83812718
137epithelial cell-cell adhesion (GO:0090136)2.82270633
138negative regulation of T-helper cell differentiation (GO:0045623)2.81611086
139negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.81611086
140regulation of calcium ion transmembrane transporter activity (GO:1901019)2.81537698
141regulation of calcium ion transmembrane transport (GO:1903169)2.81537698
142regulation of extracellular matrix disassembly (GO:0010715)2.81214946
143T cell receptor signaling pathway (GO:0050852)2.80824617
144positive regulation of natural killer cell mediated immunity (GO:0002717)2.78166265
145growth hormone secretion (GO:0030252)2.77817572
146striated muscle adaptation (GO:0014888)2.77734713
147peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.76825123
148type B pancreatic cell proliferation (GO:0044342)2.75656568
149antigen receptor-mediated signaling pathway (GO:0050851)2.75556621
150negative regulation of phagocytosis (GO:0050765)2.75012334
151positive regulation of T cell mediated cytotoxicity (GO:0001916)2.74974142
152insulin-like growth factor receptor signaling pathway (GO:0048009)2.74495101
153detection of bacterium (GO:0016045)2.73158108
154regulation of cofactor metabolic process (GO:0051193)2.72986622
155pericardium development (GO:0060039)2.72632293
156lymph node development (GO:0048535)2.72277344
157regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.70546320
158regulation of alpha-beta T cell proliferation (GO:0046640)2.69101060
159positive regulation by symbiont of host defense response (GO:0052509)2.67209387
160modulation by symbiont of host defense response (GO:0052031)2.67209387
161modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.67209387
162modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.67209387
163positive regulation by organism of defense response of other organism involved in symbiotic interact2.67209387
164modulation by symbiont of host immune response (GO:0052553)2.67209387
165negative regulation of type 2 immune response (GO:0002829)2.66260383
166atrioventricular valve morphogenesis (GO:0003181)2.64532022
167regulation of interleukin-2 biosynthetic process (GO:0045076)2.64316705
168response to laminar fluid shear stress (GO:0034616)2.64268768
169detection of other organism (GO:0098543)2.63285659
170antigen processing and presentation via MHC class Ib (GO:0002475)2.61568574
171regulation of leukocyte mediated cytotoxicity (GO:0001910)2.59912186
172positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.59654721
173bone trabecula formation (GO:0060346)2.58863406
174extracellular matrix assembly (GO:0085029)2.57946298
175regulation of dendritic cell antigen processing and presentation (GO:0002604)2.57399144
176type I interferon signaling pathway (GO:0060337)2.56601903
177cellular response to type I interferon (GO:0071357)2.56601903
178sequestering of extracellular ligand from receptor (GO:0035581)2.55901226
179response to type I interferon (GO:0034340)2.54661805
180T cell homeostasis (GO:0043029)2.53903384
181cellular extravasation (GO:0045123)2.52195479
182protein heterotrimerization (GO:0070208)2.48560341
183interferon-gamma production (GO:0032609)2.48524062
184positive regulation of cell killing (GO:0031343)2.45394797
185regulation of cell killing (GO:0031341)2.42957759
186positive regulation of fibroblast migration (GO:0010763)2.42302994
187positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.40097918
188T cell costimulation (GO:0031295)2.39520987
189positive regulation of B cell differentiation (GO:0045579)2.38768672
190negative regulation of erythrocyte differentiation (GO:0045647)2.37966688
191negative regulation of alpha-beta T cell activation (GO:0046636)2.36782306
192fibril organization (GO:0097435)2.36463316
193lymphocyte costimulation (GO:0031294)2.36302395
194regulation of defense response to virus by virus (GO:0050690)2.32240193
195negative regulation of bone remodeling (GO:0046851)2.31681721
196regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.31649738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EP300_21415370_ChIP-Seq_HL-1_Mouse3.56078403
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.37080629
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.25348353
4* TBX20_22328084_ChIP-Seq_HEART_Mouse3.22894207
5* TBX20_22080862_ChIP-Seq_HEART_Mouse3.22894207
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.19438915
7SMAD_19615063_ChIP-ChIP_OVARY_Human3.11466737
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.97677364
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.65880407
10* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.62131662
11* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.51701412
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.48691131
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.48552200
14KDM2B_26808549_Chip-Seq_DND41_Human2.42440185
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.39692499
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.26601890
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.25067812
18MYC_22102868_ChIP-Seq_BL_Human2.25021469
19* MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.17679129
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.14148087
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13933601
22ELK3_25401928_ChIP-Seq_HUVEC_Human2.11451851
23CLOCK_20551151_ChIP-Seq_293T_Human2.06367972
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.96906378
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.94378908
26TCF7_22412390_ChIP-Seq_EML_Mouse1.92156264
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90289792
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89112677
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88657403
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.87422722
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.81607512
32ZNF263_19887448_ChIP-Seq_K562_Human1.79027589
33* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74384460
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.72211525
35RUNX_20019798_ChIP-Seq_JUKART_Human1.71275597
36VDR_21846776_ChIP-Seq_THP-1_Human1.68533184
37* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67781994
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66605445
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64046342
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63530383
41* IRF8_27001747_Chip-Seq_BMDM_Mouse1.63106978
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62758150
43LXR_22292898_ChIP-Seq_THP-1_Human1.62751000
44KDM2B_26808549_Chip-Seq_JURKAT_Human1.60344283
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58917796
46* MAF_26560356_Chip-Seq_TH1_Human1.58598538
47UTX_26944678_Chip-Seq_JUKART_Human1.58224018
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.57250847
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56409983
50* MYB_26560356_Chip-Seq_TH1_Human1.55651629
51SPI1_23127762_ChIP-Seq_K562_Human1.55316839
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55237086
53GATA4_21415370_ChIP-Seq_HL-1_Mouse1.54399865
54* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51503541
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49281242
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.48610508
57STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44187106
58MAF_26560356_Chip-Seq_TH2_Human1.42425566
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.41856883
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41123365
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40889872
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40595127
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.39558406
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38931624
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38901290
66* KDM2B_26808549_Chip-Seq_K562_Human1.38379851
67NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.36796909
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36357872
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35488263
70RACK7_27058665_Chip-Seq_MCF-7_Human1.34693549
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34154978
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34071611
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.33280062
74VDR_24787735_ChIP-Seq_THP-1_Human1.30983658
75EZH2_22144423_ChIP-Seq_EOC_Human1.30726637
76DROSHA_22980978_ChIP-Seq_HELA_Human1.30292701
77PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29919780
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29883052
79* GATA3_27048872_Chip-Seq_THYMUS_Human1.29331115
80FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.26827992
81* RUNX1_27514584_Chip-Seq_MCF-7_Human1.25011560
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21675956
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20942448
84EGR1_19374776_ChIP-ChIP_THP-1_Human1.20080850
85* GATA1_19941826_ChIP-Seq_K562_Human1.20002590
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17376786
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.17083378
88VDR_24763502_ChIP-Seq_THP-1_Human1.16192729
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14523572
90ATF3_27146783_Chip-Seq_COLON_Human1.13174341
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13061873
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12575107
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12209204
94NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11879013
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11245159
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.09239350
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08887689
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08748918
99HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08361653
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06456845
101SCL_19346495_ChIP-Seq_HPC-7_Human1.06033313
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04961440
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04399035
104GATA1_19941827_ChIP-Seq_MEL_Mouse1.02929477
105WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02888062
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02597247
107* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01771728
108* MYB_26560356_Chip-Seq_TH2_Human1.01364573
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01349708
110ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99637712
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99379411
112NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99270129
113* FOXO3_23340844_ChIP-Seq_DLD1_Human0.98423239
114RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98096949
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97911055
116* TP63_22573176_ChIP-Seq_HFKS_Human0.97876497
117CREB1_26743006_Chip-Seq_LNCaP_Human0.97817668
118CJUN_26792858_Chip-Seq_BT549_Human0.97370179
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97278544
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96632661
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96332233
122* GATA2_19941826_ChIP-Seq_K562_Human0.95714892
123UBF1/2_26484160_Chip-Seq_HMECs_Human0.95169262
124DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95112805
125SPI1_23547873_ChIP-Seq_NB4_Human0.94347653
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93786079
127* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92262044
128BRD4_25478319_ChIP-Seq_HGPS_Human0.91961812
129* NCOR1_26117541_ChIP-Seq_K562_Human0.91039473
130* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90998585
131* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90865706
132TP53_23651856_ChIP-Seq_MEFs_Mouse0.90009108
133SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89496084
134CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87907641
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87309583
136NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87173248
137TP63_17297297_ChIP-ChIP_HaCaT_Human0.85822924
138NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85747829
139EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85233972
140* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.83723332
141CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83710590
142NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80696997
143GATA1_22025678_ChIP-Seq_K562_Human0.79402435
144SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.77985974
145SA1_27219007_Chip-Seq_ERYTHROID_Human0.76205751
146* GATA3_26560356_Chip-Seq_TH2_Human0.76140878
147PU_27001747_Chip-Seq_BMDM_Mouse0.75529985
148JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75432168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle6.03571030
2MP0002837_dystrophic_cardiac_calcinosis5.77994091
3MP0000751_myopathy4.36368230
4MP0004215_abnormal_myocardial_fiber4.33977916
5MP0004036_abnormal_muscle_relaxation3.96798608
6MP0005330_cardiomyopathy3.69623955
7MP0003646_muscle_fatigue3.63914945
8MP0002972_abnormal_cardiac_muscle3.06039671
9MP0008775_abnormal_heart_ventricle2.91636343
10MP0004087_abnormal_muscle_fiber2.84392883
11MP0003137_abnormal_impulse_conducting2.78883247
12MP0000749_muscle_degeneration2.74725683
13MP0010630_abnormal_cardiac_muscle2.74311697
14MP0003436_decreased_susceptibility_to2.70001975
15MP0003828_pulmonary_edema2.68958048
16MP0003724_increased_susceptibility_to2.61898645
17MP0001544_abnormal_cardiovascular_syste2.61040647
18MP0005385_cardiovascular_system_phenoty2.61040647
19MP0005671_abnormal_response_to2.53065247
20MP0000750_abnormal_muscle_regeneration2.47825869
21MP0006138_congestive_heart_failure2.44173607
22MP0005620_abnormal_muscle_contractility2.35295937
23MP0004510_myositis2.27713618
24MP0003279_aneurysm2.22481329
25MP0001835_abnormal_antigen_presentation2.21123353
26MP0004484_altered_response_of2.17432923
27MP0004130_abnormal_muscle_cell2.15638886
28MP0001800_abnormal_humoral_immune2.12819548
29MP0001542_abnormal_bone_strength2.12647066
30MP0004085_abnormal_heartbeat2.10016979
31MP0002106_abnormal_muscle_physiology2.07379639
32MP0005000_abnormal_immune_tolerance1.91853589
33MP0008438_abnormal_cutaneous_collagen1.87755965
34MP0002420_abnormal_adaptive_immunity1.78142194
35MP0001819_abnormal_immune_cell1.73895092
36MP0010368_abnormal_lymphatic_system1.72586203
37MP0002723_abnormal_immune_serum1.71625871
38MP0005623_abnormal_meninges_morphology1.71010033
39MP0005025_abnormal_response_to1.68830152
40MP0003705_abnormal_hypodermis_morpholog1.68527353
41MP0003567_abnormal_fetal_cardiomyocyte1.66302593
42MP0005369_muscle_phenotype1.65472632
43MP0000759_abnormal_skeletal_muscle1.65371026
44MP0004233_abnormal_muscle_weight1.63901818
45MP0009333_abnormal_splenocyte_physiolog1.63764343
46MP0002269_muscular_atrophy1.63168837
47MP0002452_abnormal_antigen_presenting1.62628772
48MP0006082_CNS_inflammation1.62347819
49MP0003221_abnormal_cardiomyocyte_apopto1.62159060
50MP0002405_respiratory_system_inflammati1.62008489
51MP0002127_abnormal_cardiovascular_syste1.58640876
52MP0003566_abnormal_cell_adhesion1.56317640
53MP0002419_abnormal_innate_immunity1.53659848
54MP0001533_abnormal_skeleton_physiology1.53005882
55MP0009785_altered_susceptibility_to1.49364348
56MP0000747_muscle_weakness1.48399515
57MP0000703_abnormal_thymus_morphology1.46962462
58MP0002398_abnormal_bone_marrow1.44845552
59MP0003866_abnormal_defecation1.44710028
60MP0002295_abnormal_pulmonary_circulatio1.41749046
61MP0004145_abnormal_muscle_electrophysio1.39415237
62MP0000716_abnormal_immune_system1.36994439
63MP0004883_abnormal_blood_vessel1.34070532
64MP0001348_abnormal_lacrimal_gland1.31614041
65MP0000266_abnormal_heart_morphology1.31308789
66MP0003950_abnormal_plasma_membrane1.26925374
67MP0004272_abnormal_basement_membrane1.26672693
68MP0001879_abnormal_lymphatic_vessel1.25761077
69MP0010155_abnormal_intestine_physiology1.25091011
70MP0002234_abnormal_pharynx_morphology1.24939359
71MP0005390_skeleton_phenotype1.22630114
72MP0005666_abnormal_adipose_tissue1.20638562
73MP0003448_altered_tumor_morphology1.20445546
74MP0000767_abnormal_smooth_muscle1.20222583
75MP0009384_cardiac_valve_regurgitation1.18621643
76MP0000465_gastrointestinal_hemorrhage1.18171639
77MP0002722_abnormal_immune_system1.16173076
78MP0005165_increased_susceptibility_to1.15950038
79MP0000689_abnormal_spleen_morphology1.15697381
80MP0001958_emphysema1.14344396
81MP0000858_altered_metastatic_potential1.12368219
82MP0002128_abnormal_blood_circulation1.11938260
83MP0000733_abnormal_muscle_development1.11024800
84MP0003300_gastrointestinal_ulcer1.09401551
85MP0005164_abnormal_response_to1.08731903
86MP0002998_abnormal_bone_remodeling1.08210713
87MP0005257_abnormal_intraocular_pressure1.07847053
88MP0004947_skin_inflammation1.07074703
89MP0008961_abnormal_basal_metabolism1.07027818
90MP0005275_abnormal_skin_tensile1.06116116
91MP0002877_abnormal_melanocyte_morpholog1.05653619
92MP0005375_adipose_tissue_phenotype1.04144070
93MP0001873_stomach_inflammation1.02510443
94MP0002429_abnormal_blood_cell1.02194878
95MP0006054_spinal_hemorrhage1.01662131
96MP0004185_abnormal_adipocyte_glucose1.01431687
97MP0000013_abnormal_adipose_tissue1.00345739
98MP0008260_abnormal_autophagy0.99111404
99MP0000343_altered_response_to0.99073628
100MP0001851_eye_inflammation0.98388414
101MP0001845_abnormal_inflammatory_respons0.97671480
102MP0002909_abnormal_adrenal_gland0.92834344
103MP0000003_abnormal_adipose_tissue0.92092076
104MP0002148_abnormal_hypersensitivity_rea0.90456368
105MP0001243_abnormal_dermal_layer0.88976063
106MP0005670_abnormal_white_adipose0.88236761
107MP0003191_abnormal_cellular_cholesterol0.87076507
108MP0005508_abnormal_skeleton_morphology0.86721868
109MP0005464_abnormal_platelet_physiology0.86234787
110MP0005503_abnormal_tendon_morphology0.85395511
111MP0001986_abnormal_taste_sensitivity0.83561215
112MP0003303_peritoneal_inflammation0.83144855
113MP0002925_abnormal_cardiovascular_devel0.82907090
114MP0003045_fibrosis0.81644068
115MP0003091_abnormal_cell_migration0.81147840
116MP0005595_abnormal_vascular_smooth0.79627740
117MP0003795_abnormal_bone_structure0.77861837
118MP0003172_abnormal_lysosome_physiology0.74909856
119MP0006036_abnormal_mitochondrial_physio0.73044106
120MP0002132_abnormal_respiratory_system0.70195555
121MP0001784_abnormal_fluid_regulation0.69046113
122MP0001663_abnormal_digestive_system0.68568370
123MP0001175_abnormal_lung_morphology0.66746382
124MP0002254_reproductive_system_inflammat0.66408121
125MP0002108_abnormal_muscle_morphology0.65298191
126MP0002168_other_aberrant_phenotype0.64701537
127MP0005381_digestive/alimentary_phenotyp0.64100735
128MP0002332_abnormal_exercise_endurance0.63925300
129MP0000230_abnormal_systemic_arterial0.63548861
130MP0003763_abnormal_thymus_physiology0.62717793
131MP0001614_abnormal_blood_vessel0.62200407
132MP0002166_altered_tumor_susceptibility0.60938315
133MP0002933_joint_inflammation0.56129677
134MP0009780_abnormal_chondrocyte_physiolo0.55100587
135MP0004808_abnormal_hematopoietic_stem0.51577330
136MP0010352_gastrointestinal_tract_polyps0.50800423
137MP0005377_hearing/vestibular/ear_phenot0.49449720
138MP0003878_abnormal_ear_physiology0.49449720
139MP0003984_embryonic_growth_retardation0.49035080
140MP0002088_abnormal_embryonic_growth/wei0.48530503
141MP0000428_abnormal_craniofacial_morphol0.48040867
142MP0002896_abnormal_bone_mineralization0.46232262
143MP0003385_abnormal_body_wall0.44951410
144MP0005187_abnormal_penis_morphology0.43586534
145MP0002078_abnormal_glucose_homeostasis0.38550580
146MP0005023_abnormal_wound_healing0.38284501
147MP0000249_abnormal_blood_vessel0.37940885
148MP0002133_abnormal_respiratory_system0.37470545
149MP0005388_respiratory_system_phenotype0.37470545
150MP0003935_abnormal_craniofacial_develop0.37044575
151MP0009278_abnormal_bone_marrow0.36520116
152MP0000685_abnormal_immune_system0.35458365
153MP0005387_immune_system_phenotype0.35409469
154MP0001790_abnormal_immune_system0.35409469
155MP0003115_abnormal_respiratory_system0.34894348
156MP0003948_abnormal_gas_homeostasis0.34028892

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.05861902
2Ventricular tachycardia (HP:0004756)6.63977623
3Atrial fibrillation (HP:0005110)5.98402316
4Subaortic stenosis (HP:0001682)5.74509238
5Abnormality of the left ventricular outflow tract (HP:0011103)5.74509238
6Primary atrial arrhythmia (HP:0001692)5.63945271
7Supraventricular tachycardia (HP:0004755)5.43215408
8Supraventricular arrhythmia (HP:0005115)5.38015684
9Lipoatrophy (HP:0100578)5.17475198
10Syncope (HP:0001279)4.94919481
11Right ventricular cardiomyopathy (HP:0011663)4.91061907
12Muscle fiber splitting (HP:0003555)4.65690436
13Prolonged QT interval (HP:0001657)4.63792264
14Calf muscle hypertrophy (HP:0008981)4.60322461
15Abnormality of the calf musculature (HP:0001430)4.53640464
16Asymmetric septal hypertrophy (HP:0001670)4.42307442
17Bundle branch block (HP:0011710)4.32138467
18Ventricular fibrillation (HP:0001663)4.32052750
19Vascular tortuosity (HP:0004948)4.28493704
20Exercise-induced muscle cramps (HP:0003710)4.22726678
21Ventricular arrhythmia (HP:0004308)4.18653702
22Hyporeflexia of lower limbs (HP:0002600)4.18552040
23Dilated cardiomyopathy (HP:0001644)4.13038739
24Exercise-induced myalgia (HP:0003738)4.04210194
25Muscle hypertrophy of the lower extremities (HP:0008968)3.98618086
26Eczematoid dermatitis (HP:0000976)3.92861341
27Palpitations (HP:0001962)3.82949381
28Dilatation of the ascending aorta (HP:0005111)3.80560630
29Peritonitis (HP:0002586)3.80024115
30Arterial tortuosity (HP:0005116)3.74675134
31Atrioventricular block (HP:0001678)3.74048077
32T lymphocytopenia (HP:0005403)3.73225568
33Heart block (HP:0012722)3.54458908
34Myoglobinuria (HP:0002913)3.48941785
35EMG: myopathic abnormalities (HP:0003458)3.46435144
36Abnormality of T cell number (HP:0011839)3.43175517
37Abnormal atrioventricular conduction (HP:0005150)3.40373417
38Increased connective tissue (HP:0009025)3.34844234
39Elevated erythrocyte sedimentation rate (HP:0003565)3.32408861
40Abnormal EKG (HP:0003115)3.25579346
41Spondylolisthesis (HP:0003302)3.14611921
42Spontaneous hematomas (HP:0007420)3.11865919
43Gastrointestinal infarctions (HP:0005244)3.02082553
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.96099251
45Soft skin (HP:0000977)2.94546356
46Broad metatarsal (HP:0001783)2.92685329
47Myositis (HP:0100614)2.90245647
48Difficulty running (HP:0009046)2.80621371
49Sudden cardiac death (HP:0001645)2.73439647
50Emphysema (HP:0002097)2.73317982
51Mitral valve prolapse (HP:0001634)2.73310507
52Myotonia (HP:0002486)2.71467603
53Protrusio acetabuli (HP:0003179)2.65126629
54Cervical subluxation (HP:0003308)2.63040344
55Mildly elevated creatine phosphokinase (HP:0008180)2.56268355
56Difficulty climbing stairs (HP:0003551)2.56164519
57Left ventricular hypertrophy (HP:0001712)2.54229863
58Slender build (HP:0001533)2.54038840
59Abnormality of macrophages (HP:0004311)2.53367362
60Stomatitis (HP:0010280)2.53301493
61Wormian bones (HP:0002645)2.51265929
62Recurrent bronchitis (HP:0002837)2.49867302
63Pustule (HP:0200039)2.49124829
64Cerebral aneurysm (HP:0004944)2.48951714
65Increased variability in muscle fiber diameter (HP:0003557)2.48621696
66Genu recurvatum (HP:0002816)2.46653536
67Type 1 muscle fiber predominance (HP:0003803)2.45399365
68Recurrent abscess formation (HP:0002722)2.43494092
69Recurrent fungal infections (HP:0002841)2.39953378
70Cellulitis (HP:0100658)2.39218120
71Lymphangioma (HP:0100764)2.37193273
72Conjunctival hamartoma (HP:0100780)2.37170283
73Atrophic scars (HP:0001075)2.35612414
74Rhabdomyolysis (HP:0003201)2.35230749
75Orchitis (HP:0100796)2.32631373
76Leukocytosis (HP:0001974)2.30950300
77Ragged-red muscle fibers (HP:0003200)2.30457334
78Abnormality of T cells (HP:0002843)2.27579743
79Follicular hyperkeratosis (HP:0007502)2.25406383
80Palmoplantar keratoderma (HP:0000982)2.23959386
81Fragile skin (HP:0001030)2.23905528
82Limb-girdle muscle atrophy (HP:0003797)2.22508248
83Meningitis (HP:0001287)2.21553809
84Pulmonary infiltrates (HP:0002113)2.21220700
85Persistence of primary teeth (HP:0006335)2.21044509
86Ankle contracture (HP:0006466)2.20437075
87Premature rupture of membranes (HP:0001788)2.20404914
88Mitral regurgitation (HP:0001653)2.19587789
89Vasculitis (HP:0002633)2.18832679
90Scapular winging (HP:0003691)2.18816070
91Blue sclerae (HP:0000592)2.18350017
92Joint laxity (HP:0001388)2.17752355
93Lymphopenia (HP:0001888)2.16955457
94Chronic mucocutaneous candidiasis (HP:0002728)2.16870089
95Recurrent cutaneous fungal infections (HP:0011370)2.16870089
96Abnormality of skeletal muscle fiber size (HP:0012084)2.16175772
97Recurrent bacterial skin infections (HP:0005406)2.14505920
98Disproportionate tall stature (HP:0001519)2.13784476
99Aortic valve stenosis (HP:0001650)2.13580758
100Hypoventilation (HP:0002791)2.12502708
101Nonimmune hydrops fetalis (HP:0001790)2.11724019
102Agammaglobulinemia (HP:0004432)2.10478812
103Aortic regurgitation (HP:0001659)2.09921703
104Congestive heart failure (HP:0001635)2.09228976
105Interstitial pulmonary disease (HP:0006530)2.09214009
106Abnormality of the tricuspid valve (HP:0001702)2.09023238
107Increased IgE level (HP:0003212)2.08229948
108Aneurysm (HP:0002617)2.05205288
109Large for gestational age (HP:0001520)2.04505481
110Hypoglycemic coma (HP:0001325)2.04113512
111Centrally nucleated skeletal muscle fibers (HP:0003687)2.03990836
112Gingivitis (HP:0000230)2.02001682
113Broad ribs (HP:0000885)2.01876313
114Abnormality of the peritoneum (HP:0002585)2.01459253
115Hamartoma of the eye (HP:0010568)2.00963985
116Ketoacidosis (HP:0001993)1.99461156
117Retrobulbar optic neuritis (HP:0100654)1.99281195
118Optic neuritis (HP:0100653)1.99281195
119Abnormality of cells of the lymphoid lineage (HP:0012140)1.98974885
120Striae distensae (HP:0001065)1.97645602
121Joint stiffness (HP:0001387)1.97442552
122Vertebral compression fractures (HP:0002953)1.97426105
123Biconcave vertebral bodies (HP:0004586)1.96633722
124Ectopia lentis (HP:0001083)1.96369285
125Dysmetric saccades (HP:0000641)1.96215797
126Hypoplastic ischia (HP:0003175)1.94186497
127Pulmonary artery stenosis (HP:0004415)1.93739767
128Chest pain (HP:0100749)1.93453653
129Hypergammaglobulinemia (HP:0010702)1.93261398
130Gastrointestinal stroma tumor (HP:0100723)1.92576794
131Increased IgM level (HP:0003496)1.92028022
132Abnormality of the fingertips (HP:0001211)1.91410973
133Abnormality of dentin (HP:0010299)1.88981573
134Microcytic anemia (HP:0001935)1.88919237
135Recurrent viral infections (HP:0004429)1.88485583
136Aortic aneurysm (HP:0004942)1.85112162
137Panhypogammaglobulinemia (HP:0003139)1.85031407
138Abnormality of eosinophils (HP:0001879)1.84997416
139Encephalitis (HP:0002383)1.84896766
140Wide anterior fontanel (HP:0000260)1.84346472
141Wrist flexion contracture (HP:0001239)1.84164970
142Distal lower limb amyotrophy (HP:0008944)1.84034917
143Papilledema (HP:0001085)1.83307682
144Neonatal short-limb short stature (HP:0008921)1.82067904
145EMG: neuropathic changes (HP:0003445)1.80352027
146Abnormality of the endocardium (HP:0004306)1.79305535
147Eosinophilia (HP:0001880)1.79094549
148Abnormality of the foot musculature (HP:0001436)1.78940077
149Abnormality of the pulmonary veins (HP:0011718)1.77828411
150Aortic dissection (HP:0002647)1.77578533
151Hyperacusis (HP:0010780)1.77473016
152Bladder diverticulum (HP:0000015)1.76460450
153Neck muscle weakness (HP:0000467)1.75469296
154Shallow orbits (HP:0000586)1.67396367
155Neoplasm of the adrenal gland (HP:0100631)1.66811331
156Multiple enchondromatosis (HP:0005701)1.65572552
157Abnormality of the ischium (HP:0003174)1.65257821
158Hypoplastic left heart (HP:0004383)1.64890993
159Bicuspid aortic valve (HP:0001647)1.64360649
160Generalized muscle weakness (HP:0003324)1.64085843
161Thin bony cortex (HP:0002753)1.63612709
162Polycythemia (HP:0001901)1.63475733
163Facial diplegia (HP:0001349)1.63401705
164Rectal prolapse (HP:0002035)1.62949518
165Pheochromocytoma (HP:0002666)1.62154077
166Hypercortisolism (HP:0001578)1.61983242
167Cavernous hemangioma (HP:0001048)1.61546398
168Papilloma (HP:0012740)1.59892624
169Verrucae (HP:0200043)1.59892624
170Lower limb amyotrophy (HP:0007210)1.59830716
171Central scotoma (HP:0000603)1.58984318
172Gowers sign (HP:0003391)1.57513479
173Subacute progressive viral hepatitis (HP:0006572)1.57185772
174Mesangial abnormality (HP:0001966)1.57062214
175Patent foramen ovale (HP:0001655)1.56605425
176Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.54910605
177Hematochezia (HP:0002573)1.51895952
178Spinal rigidity (HP:0003306)1.51805886
179Double outlet right ventricle (HP:0001719)1.51171826
180Congenital malformation of the right heart (HP:0011723)1.51171826

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN24.88803606
2TRIB34.71283270
3TTN4.50733675
4DMPK3.26576859
5LMTK23.24839923
6MYLK3.08126237
7TXK2.67993680
8PRPF4B2.64590820
9PHKG22.45245633
10PHKG12.45245633
11STK242.41948807
12TYK22.26546681
13MAP3K102.05057597
14TIE11.93570777
15PIK3CA1.89759293
16PDK41.80968720
17PDK31.80968720
18FES1.80810503
19ILK1.75957238
20PDGFRA1.75439394
21MAP4K11.66821159
22OBSCN1.56323271
23PRKD11.55288102
24PIK3CG1.49853491
25BTK1.48946467
26BLK1.46107321
27CDC42BPA1.44891959
28MAP3K31.38688360
29PAK31.38248290
30EEF2K1.36610267
31LRRK21.35398479
32RIPK41.34230448
33TGFBR21.31512549
34MAP3K71.28364942
35PTK61.24817568
36KIT1.24451863
37RIPK11.23424970
38IKBKE1.22512693
39TESK11.21988651
40FLT31.21938042
41SYK1.21151719
42LCK1.20312635
43NEK11.14070234
44ERN11.12509422
45SIK31.08522442
46ROCK11.07087646
47WNK41.04524574
48EPHB11.04112844
49SIK21.03194659
50FGFR40.99993304
51PRKCH0.99896280
52MAPK70.94720092
53PRKD20.92656404
54DDR20.92400009
55IRAK40.92086975
56MAP3K110.90441191
57MUSK0.89789981
58KDR0.89296676
59MAPK120.88696256
60JAK10.88523789
61LYN0.87554748
62TEC0.87000025
63FGFR30.86500976
64MAP3K130.85918561
65RET0.85222253
66WNK10.83972227
67PDK20.82699873
68PDGFRB0.82300240
69SIK10.81281879
70EPHA30.81172547
71STK380.80846830
72DAPK30.80600211
73STK40.79962616
74BCKDK0.79260752
75ITK0.78605307
76TNK20.76365709
77ZAP700.75627539
78MAP3K60.74959376
79TRPM70.74832100
80CAMK2D0.74612639
81RPS6KA20.70966554
82TESK20.70733673
83ADRBK10.69137550
84FYN0.68584149
85TBK10.68245803
86CAMK40.67595645
87CLK10.66162224
88CAMKK20.64007901
89INSRR0.63811160
90EPHB20.61432225
91MAP3K50.60186639
92ROCK20.59733025
93PRKAA10.58715005
94HIPK20.56785744
95MARK30.55350071
96KSR20.55308065
97MAP3K140.54474304
98GRK70.53800674
99PASK0.53529044
100MTOR0.53422387
101PAK20.53266094
102LIMK10.52404469
103PRKAA20.51893021
104TAOK10.51472659
105MAPKAPK30.51360580
106STK100.50868667
107JAK30.48963434
108DYRK1B0.48763926
109PDK10.47654845
110TYRO30.47311349
111MAP2K30.47002345
112CAMK10.46031044
113MARK20.45863014
114GRK50.45162477
115MAPK40.44479459
116RPS6KC10.43702925
117RPS6KL10.43702925
118PRKG20.43367408
119MAPK110.43054413
120TAOK30.42959477
121PRKD30.42368967
122ICK0.41109446
123LATS10.41063092
124PDPK10.40663581
125PTK2B0.40092346
126ALK0.39876921
127RPS6KA60.39445812
128TGFBR10.39062625
129PRKCQ0.39057445
130JAK20.36532711
131NLK0.36020135
132CAMK1G0.35961719
133CSK0.35815082
134UHMK10.35685988
135PKN10.35470261
136MAP3K10.34923823
137HCK0.34786478
138CAMKK10.32874318
139GRK60.31833866
140NEK90.31342021

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.50792670
2Dilated cardiomyopathy_Homo sapiens_hsa054143.93552420
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.70189728
4Cardiac muscle contraction_Homo sapiens_hsa042603.22277325
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.84270301
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.68860983
7Viral myocarditis_Homo sapiens_hsa054162.52411721
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.03195643
9Graft-versus-host disease_Homo sapiens_hsa053322.00589970
10Autoimmune thyroid disease_Homo sapiens_hsa053201.96612778
11Allograft rejection_Homo sapiens_hsa053301.89051745
12Fatty acid degradation_Homo sapiens_hsa000711.77153917
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.76752584
14Malaria_Homo sapiens_hsa051441.64670674
15Hematopoietic cell lineage_Homo sapiens_hsa046401.64147987
16Focal adhesion_Homo sapiens_hsa045101.61814619
17Propanoate metabolism_Homo sapiens_hsa006401.59724672
18Measles_Homo sapiens_hsa051621.58922040
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48496856
20cGMP-PKG signaling pathway_Homo sapiens_hsa040221.42683834
21Insulin resistance_Homo sapiens_hsa049311.38786575
22Antigen processing and presentation_Homo sapiens_hsa046121.33767611
23Parkinsons disease_Homo sapiens_hsa050121.33167439
24ECM-receptor interaction_Homo sapiens_hsa045121.31891688
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.31479057
26Carbon metabolism_Homo sapiens_hsa012001.23268462
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.22355626
28Type I diabetes mellitus_Homo sapiens_hsa049401.22224768
29Fatty acid metabolism_Homo sapiens_hsa012121.17653901
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13745477
31Adherens junction_Homo sapiens_hsa045201.13698260
32Staphylococcus aureus infection_Homo sapiens_hsa051501.13406273
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09990063
34Pancreatic secretion_Homo sapiens_hsa049721.08737122
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.08697380
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08569756
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08277602
38Insulin signaling pathway_Homo sapiens_hsa049101.05295717
39Hepatitis B_Homo sapiens_hsa051611.02489847
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01344977
41Lysine degradation_Homo sapiens_hsa003101.01241527
42Alzheimers disease_Homo sapiens_hsa050101.01119224
43TNF signaling pathway_Homo sapiens_hsa046681.00987458
44Shigellosis_Homo sapiens_hsa051311.00536194
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.00292838
46Platelet activation_Homo sapiens_hsa046111.00092437
47Type II diabetes mellitus_Homo sapiens_hsa049300.99997380
48Primary immunodeficiency_Homo sapiens_hsa053400.99722459
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99645557
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99541519
51Glucagon signaling pathway_Homo sapiens_hsa049220.98530102
52B cell receptor signaling pathway_Homo sapiens_hsa046620.97995801
53Tuberculosis_Homo sapiens_hsa051520.97922144
54Endocytosis_Homo sapiens_hsa041440.97210321
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97150293
56Protein digestion and absorption_Homo sapiens_hsa049740.96115726
57Chronic myeloid leukemia_Homo sapiens_hsa052200.95799443
58Phagosome_Homo sapiens_hsa041450.95708287
59Proteoglycans in cancer_Homo sapiens_hsa052050.95603910
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.95517894
61HIF-1 signaling pathway_Homo sapiens_hsa040660.94935818
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92868504
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91652391
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91302934
65Amoebiasis_Homo sapiens_hsa051460.88417487
66Toxoplasmosis_Homo sapiens_hsa051450.88153392
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88138667
68Small cell lung cancer_Homo sapiens_hsa052220.87031279
69Influenza A_Homo sapiens_hsa051640.85149852
70VEGF signaling pathway_Homo sapiens_hsa043700.83286853
71Renal cell carcinoma_Homo sapiens_hsa052110.82505878
72Oxidative phosphorylation_Homo sapiens_hsa001900.79975487
73Apoptosis_Homo sapiens_hsa042100.79653063
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.79319848
75Hepatitis C_Homo sapiens_hsa051600.79082727
76AMPK signaling pathway_Homo sapiens_hsa041520.78535975
77Oxytocin signaling pathway_Homo sapiens_hsa049210.76984913
78mTOR signaling pathway_Homo sapiens_hsa041500.76797762
79Osteoclast differentiation_Homo sapiens_hsa043800.76619877
80Herpes simplex infection_Homo sapiens_hsa051680.76391650
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76366021
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76121724
83T cell receptor signaling pathway_Homo sapiens_hsa046600.75093414
84Endometrial cancer_Homo sapiens_hsa052130.74447129
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74358937
86Notch signaling pathway_Homo sapiens_hsa043300.74174404
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.73524496
88Ras signaling pathway_Homo sapiens_hsa040140.73416881
89Insulin secretion_Homo sapiens_hsa049110.73059842
90Choline metabolism in cancer_Homo sapiens_hsa052310.72632313
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72577789
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70585794
93Renin secretion_Homo sapiens_hsa049240.70135772
94Salmonella infection_Homo sapiens_hsa051320.69888312
95Acute myeloid leukemia_Homo sapiens_hsa052210.68975598
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.68748712
97Gastric acid secretion_Homo sapiens_hsa049710.68188717
98cAMP signaling pathway_Homo sapiens_hsa040240.67640886
99Pertussis_Homo sapiens_hsa051330.67269737
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65885806
101Tight junction_Homo sapiens_hsa045300.65522136
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.65521710
103Prostate cancer_Homo sapiens_hsa052150.63925586
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.63616570
105Pancreatic cancer_Homo sapiens_hsa052120.62427527
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62095757
107Calcium signaling pathway_Homo sapiens_hsa040200.61859935
108Dorso-ventral axis formation_Homo sapiens_hsa043200.61039713
109Other glycan degradation_Homo sapiens_hsa005110.60567034
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59347622
111Estrogen signaling pathway_Homo sapiens_hsa049150.59108202
112Pyruvate metabolism_Homo sapiens_hsa006200.58345585
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57998299
114Non-small cell lung cancer_Homo sapiens_hsa052230.57118817
115Inositol phosphate metabolism_Homo sapiens_hsa005620.53791320
116Huntingtons disease_Homo sapiens_hsa050160.53381930
117Glioma_Homo sapiens_hsa052140.53028773
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52837342
119Rheumatoid arthritis_Homo sapiens_hsa053230.52830696
120Rap1 signaling pathway_Homo sapiens_hsa040150.52771620
121Axon guidance_Homo sapiens_hsa043600.52335119
122Viral carcinogenesis_Homo sapiens_hsa052030.51983063
123African trypanosomiasis_Homo sapiens_hsa051430.51819789
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50558044
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.49917985
126Cholinergic synapse_Homo sapiens_hsa047250.49495935
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49476387
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48156235
129FoxO signaling pathway_Homo sapiens_hsa040680.47401365
130MicroRNAs in cancer_Homo sapiens_hsa052060.46685190
131Prolactin signaling pathway_Homo sapiens_hsa049170.46511010
132GnRH signaling pathway_Homo sapiens_hsa049120.46229170
133Gap junction_Homo sapiens_hsa045400.44174800
134Pathways in cancer_Homo sapiens_hsa052000.42703420
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42630660
136HTLV-I infection_Homo sapiens_hsa051660.41467017
137Colorectal cancer_Homo sapiens_hsa052100.41383375
138Leishmaniasis_Homo sapiens_hsa051400.41327703
139MAPK signaling pathway_Homo sapiens_hsa040100.41321055
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40489825
141Chemokine signaling pathway_Homo sapiens_hsa040620.39366787
142Circadian entrainment_Homo sapiens_hsa047130.37740089
143Starch and sucrose metabolism_Homo sapiens_hsa005000.37323160
144Melanogenesis_Homo sapiens_hsa049160.36717833
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.36422564

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