LBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.13721652
2epoxygenase P450 pathway (GO:0019373)8.10459704
3drug catabolic process (GO:0042737)8.00216454
4omega-hydroxylase P450 pathway (GO:0097267)7.96365846
5negative regulation of protein activation cascade (GO:2000258)7.16820685
6negative regulation of complement activation (GO:0045916)7.03974352
7regulation of protein activation cascade (GO:2000257)6.54119773
8regulation of complement activation (GO:0030449)6.46516175
9drug metabolic process (GO:0017144)5.75393135
10complement activation, alternative pathway (GO:0006957)5.55172984
11oxidative demethylation (GO:0070989)5.15160378
12positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.12317348
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.10248822
14L-phenylalanine catabolic process (GO:0006559)5.10248822
15negative regulation of humoral immune response (GO:0002921)5.09488908
16L-phenylalanine metabolic process (GO:0006558)4.86422599
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.86422599
18negative regulation of fibrinolysis (GO:0051918)4.80740510
19protein carboxylation (GO:0018214)4.74248701
20peptidyl-glutamic acid carboxylation (GO:0017187)4.74248701
21phenylpropanoid metabolic process (GO:0009698)4.71494973
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.70709538
23regulation of apoptotic cell clearance (GO:2000425)4.59631322
24sulfur amino acid catabolic process (GO:0000098)4.58231919
25glycine metabolic process (GO:0006544)4.54943461
26* acute inflammatory response (GO:0002526)4.53322527
27regulation of fibrinolysis (GO:0051917)4.52071503
28alpha-linolenic acid metabolic process (GO:0036109)4.51834296
29aromatic amino acid family catabolic process (GO:0009074)4.51372121
30ethanol metabolic process (GO:0006067)4.36642614
31cellular biogenic amine catabolic process (GO:0042402)4.26771858
32amine catabolic process (GO:0009310)4.26771858
33S-adenosylmethionine metabolic process (GO:0046500)4.25484769
34disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.23811622
35killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.23811622
36complement activation, classical pathway (GO:0006958)4.19813094
37cysteine metabolic process (GO:0006534)4.17270867
38complement activation (GO:0006956)4.17168037
39high-density lipoprotein particle remodeling (GO:0034375)4.15644987
40glyoxylate metabolic process (GO:0046487)4.15074937
41reverse cholesterol transport (GO:0043691)4.13510109
42regulation of acute inflammatory response (GO:0002673)4.12023261
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.10593994
44fibrinolysis (GO:0042730)4.08689940
45indole-containing compound catabolic process (GO:0042436)4.06845944
46indolalkylamine catabolic process (GO:0046218)4.06845944
47tryptophan catabolic process (GO:0006569)4.06845944
48bile acid biosynthetic process (GO:0006699)4.06613107
49* opsonization (GO:0008228)3.98348392
50kynurenine metabolic process (GO:0070189)3.98060973
51flavonoid metabolic process (GO:0009812)3.97684144
52regulation of humoral immune response (GO:0002920)3.96888027
53protein activation cascade (GO:0072376)3.96803646
54urea cycle (GO:0000050)3.91413875
55urea metabolic process (GO:0019627)3.91413875
56regulation of triglyceride catabolic process (GO:0010896)3.89908676
57carnitine metabolic process (GO:0009437)3.88356717
58tryptophan metabolic process (GO:0006568)3.81252948
59protein-lipid complex remodeling (GO:0034368)3.76307585
60macromolecular complex remodeling (GO:0034367)3.76307585
61plasma lipoprotein particle remodeling (GO:0034369)3.76307585
62blood coagulation, intrinsic pathway (GO:0007597)3.75286581
63phospholipid efflux (GO:0033700)3.75218897
64arginine metabolic process (GO:0006525)3.72248303
65alkaloid metabolic process (GO:0009820)3.71755134
66triglyceride homeostasis (GO:0070328)3.69109583
67acylglycerol homeostasis (GO:0055090)3.69109583
68plasma lipoprotein particle clearance (GO:0034381)3.68843855
69positive regulation of extracellular matrix organization (GO:1903055)3.63618548
70glutamate metabolic process (GO:0006536)3.63310953
71heme transport (GO:0015886)3.63145664
72serine family amino acid metabolic process (GO:0009069)3.58620473
73nitrogen cycle metabolic process (GO:0071941)3.56371265
74amino-acid betaine metabolic process (GO:0006577)3.56246222
75bile acid and bile salt transport (GO:0015721)3.54436548
76bile acid metabolic process (GO:0008206)3.53256667
77positive regulation of triglyceride lipase activity (GO:0061365)3.53039465
78positive regulation of lipoprotein lipase activity (GO:0051006)3.53039465
79intestinal cholesterol absorption (GO:0030299)3.48959561
80serine family amino acid catabolic process (GO:0009071)3.47091538
81positive regulation of blood coagulation (GO:0030194)3.45790515
82positive regulation of hemostasis (GO:1900048)3.45790515
83regulation of cholesterol esterification (GO:0010872)3.44932805
84cellular glucuronidation (GO:0052695)3.43857104
85homocysteine metabolic process (GO:0050667)3.40811557
86serine family amino acid biosynthetic process (GO:0009070)3.40273899
87* acute-phase response (GO:0006953)3.40230924
88ethanol oxidation (GO:0006069)3.39114211
89ovulation from ovarian follicle (GO:0001542)3.37301806
90positive regulation of fatty acid biosynthetic process (GO:0045723)3.37230889
91xenobiotic metabolic process (GO:0006805)3.37080676
92phospholipid homeostasis (GO:0055091)3.35471131
93negative regulation of lipase activity (GO:0060192)3.34295759
94cholesterol efflux (GO:0033344)3.32318271
95positive regulation of coagulation (GO:0050820)3.31977773
96basement membrane organization (GO:0071711)3.27988050
97negative regulation of blood coagulation (GO:0030195)3.25692952
98negative regulation of hemostasis (GO:1900047)3.25692952
99hormone catabolic process (GO:0042447)3.22409964
100regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.20648977
101regulation of plasminogen activation (GO:0010755)3.18008386
102response to hydroperoxide (GO:0033194)3.17168620
103low-density lipoprotein particle remodeling (GO:0034374)3.14870387
104cellular modified amino acid catabolic process (GO:0042219)3.12676273
105plasma lipoprotein particle assembly (GO:0034377)3.11976737
106tyrosine metabolic process (GO:0006570)3.11605425
107aromatic amino acid family metabolic process (GO:0009072)3.11002038
108lipoprotein metabolic process (GO:0042157)3.08915622
109hydrogen peroxide catabolic process (GO:0042744)3.07010692
110glucuronate metabolic process (GO:0019585)3.04024294
111uronic acid metabolic process (GO:0006063)3.04024294
112negative regulation of wound healing (GO:0061045)3.02461680
113plasma lipoprotein particle organization (GO:0071827)3.01796108
114alpha-amino acid catabolic process (GO:1901606)3.01763189
115imidazole-containing compound metabolic process (GO:0052803)3.01581215
116cytolysis (GO:0019835)3.01062944
117benzene-containing compound metabolic process (GO:0042537)2.98646232
118negative regulation of coagulation (GO:0050819)2.98214889
119regulation of triglyceride metabolic process (GO:0090207)2.97198612
120lysine metabolic process (GO:0006553)2.93820464
121lysine catabolic process (GO:0006554)2.93820464
122regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.92350395
123negative regulation of cholesterol transport (GO:0032375)2.91030963
124negative regulation of sterol transport (GO:0032372)2.91030963
125cholesterol homeostasis (GO:0042632)2.90390975
126positive regulation of lipid catabolic process (GO:0050996)2.90080022
127positive regulation of triglyceride metabolic process (GO:0090208)2.90006351
128protein-lipid complex assembly (GO:0065005)2.89712131
129protein-lipid complex subunit organization (GO:0071825)2.89525087

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.54505155
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.10575060
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.22796553
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.04461621
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.87181559
6* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.57673988
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.59757050
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.50769915
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.06841095
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.93105080
11CLOCK_20551151_ChIP-Seq_293T_Human2.89649414
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66469989
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.63656141
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.44094645
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.40175624
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.26613306
17ESR1_15608294_ChIP-ChIP_MCF-7_Human2.19700909
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.09482974
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.06685772
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.90676972
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81272537
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79503093
23* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.72308959
24CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.70781598
25GATA1_22025678_ChIP-Seq_K562_Human1.70699346
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68079628
27* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65398814
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.57198486
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55696080
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48614431
31BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42764642
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38210125
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.36296654
34SOX2_20726797_ChIP-Seq_SW620_Human1.32895730
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32799035
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.31770552
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29055873
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.28952500
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26711534
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.26062644
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25872431
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25551179
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23383925
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19586146
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15847016
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13993368
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13993368
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13837603
49CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.12468273
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.11542484
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11466878
52ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09153738
53* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08940720
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06764506
55CJUN_26792858_Chip-Seq_BT549_Human1.06530871
56PHF8_20622853_ChIP-Seq_HELA_Human1.06034403
57PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04896372
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.04795276
59GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04781748
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02959645
61HNFA_21074721_ChIP-Seq_CACO-2_Human1.02930855
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02378597
63LXR_22292898_ChIP-Seq_THP-1_Human1.01869986
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01836981
65GATA4_25053715_ChIP-Seq_YYC3_Human0.99682672
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99475967
67RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94832461
68NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94728470
69ELK3_25401928_ChIP-Seq_HUVEC_Human0.94490888
70SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93767041
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93567224
72* HNF4A_19822575_ChIP-Seq_HepG2_Human0.92805372
73GATA6_21074721_ChIP-Seq_CACO-2_Human0.91280569
74RACK7_27058665_Chip-Seq_MCF-7_Human0.91003455
75NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90616655
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90588857
77CBP_21632823_ChIP-Seq_H3396_Human0.87662109
78BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86494652
79PIAS1_25552417_ChIP-Seq_VCAP_Human0.86425203
80IRF8_27001747_Chip-Seq_BMDM_Mouse0.85660738
81TBX20_22328084_ChIP-Seq_HEART_Mouse0.83662439
82TBX20_22080862_ChIP-Seq_HEART_Mouse0.83662439
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82299770
84SCL_19346495_ChIP-Seq_HPC-7_Human0.82135011
85AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81551503
86GATA3_24758297_ChIP-Seq_MCF-7_Human0.80845197
87CDX2_20551321_ChIP-Seq_CACO-2_Human0.79929312
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79778610
89NFYA_21822215_ChIP-Seq_K562_Human0.79760331
90GATA1_19941826_ChIP-Seq_K562_Human0.79224453
91ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77411202
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.77032025
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.77032025
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.76914567
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.76622590
96P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75831211
97KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75443446
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.75327512
99BCAT_22108803_ChIP-Seq_LS180_Human0.74357962
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73548840
101ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.73515177
102NFE2_27457419_Chip-Seq_LIVER_Mouse0.73341993
103HIF1A_21447827_ChIP-Seq_MCF-7_Human0.73328651
104ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73239928
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.72944795
106HTT_18923047_ChIP-ChIP_STHdh_Human0.72906800
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.72328907
108FOXM1_23109430_ChIP-Seq_U2OS_Human0.72125765
109TP53_18474530_ChIP-ChIP_U2OS_Human0.72081945
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71933102
111EZH2_27294783_Chip-Seq_NPCs_Mouse0.71492698
112PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.69917222
113RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69216541
114EP300_21415370_ChIP-Seq_HL-1_Mouse0.68893181
115AR_20517297_ChIP-Seq_VCAP_Human0.68193694
116GATA2_19941826_ChIP-Seq_K562_Human0.67923035
117IRF8_21731497_ChIP-ChIP_J774_Mouse0.66541086
118STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.65999821
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.65867614
120PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.65576036
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65571132
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.65228161
123ER_23166858_ChIP-Seq_MCF-7_Human0.65159929
124FOXM1_26456572_ChIP-Seq_MCF-7_Human0.64987474
125ETV1_20927104_ChIP-Seq_GIST48_Human0.64461691
126FOXA1_25552417_ChIP-Seq_VCAP_Human0.64039005
127* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.63391767
128EGR1_19374776_ChIP-ChIP_THP-1_Human0.63330445
129NANOG_19829295_ChIP-Seq_ESCs_Human0.62378937
130SOX2_19829295_ChIP-Seq_ESCs_Human0.62378937
131NFYB_21822215_ChIP-Seq_K562_Human0.61759505
132* OCT4_18555785_Chip-Seq_ESCs_Mouse0.60365812
133CBX2_22325352_ChIP-Seq_293T-Rex_Human0.60042819
134CEBPB_22108803_ChIP-Seq_LS180_Human0.59387458
135RBPJ_21746931_ChIP-Seq_IB4_Human0.59156367
136GATA6_25053715_ChIP-Seq_YYC3_Human0.59111883
137CDX2_22108803_ChIP-Seq_LS180_Human0.58961749
138AR_21909140_ChIP-Seq_LNCAP_Human0.58525136
139SOX2_21211035_ChIP-Seq_LN229_Human0.57712916
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.57258193
141RUNX1_27457419_Chip-Seq_LIVER_Mouse0.56072250
142SUZ12_27294783_Chip-Seq_NPCs_Mouse0.55685670
143* PU1_27457419_Chip-Seq_LIVER_Mouse0.55517566
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.54859325
145TAF2_19829295_ChIP-Seq_ESCs_Human0.54826712
146* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.53374187
147SPI1_20517297_ChIP-Seq_HL60_Human0.53370961

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.22617109
2MP0005360_urolithiasis4.69952981
3MP0002254_reproductive_system_inflammat4.52238669
4MP0008438_abnormal_cutaneous_collagen4.43005155
5MP0005085_abnormal_gallbladder_physiolo4.18107948
6MP0005365_abnormal_bile_salt3.97873882
7MP0008875_abnormal_xenobiotic_pharmacok3.75993589
8MP0003950_abnormal_plasma_membrane3.28833178
9MP0003191_abnormal_cellular_cholesterol3.14978504
10MP0010329_abnormal_lipoprotein_level2.94885222
11MP0003252_abnormal_bile_duct2.85134790
12MP0009697_abnormal_copulation2.20810542
13MP0009840_abnormal_foam_cell2.19318248
14MP0003806_abnormal_nucleotide_metabolis2.18860463
15MP0005275_abnormal_skin_tensile2.13420261
16MP0005083_abnormal_biliary_tract2.10062340
17MP0006054_spinal_hemorrhage2.07990278
18MP0000604_amyloidosis2.02548936
19MP0004019_abnormal_vitamin_homeostasis2.00418891
20MP0010368_abnormal_lymphatic_system1.92514683
21MP0001666_abnormal_nutrient_absorption1.89204666
22MP0005332_abnormal_amino_acid1.81517586
23MP0001958_emphysema1.80904770
24MP0001881_abnormal_mammary_gland1.78623508
25MP0003279_aneurysm1.76943718
26MP0003705_abnormal_hypodermis_morpholog1.73490568
27MP0004883_abnormal_blood_vessel1.70646618
28MP0005164_abnormal_response_to1.65596865
29MP0002118_abnormal_lipid_homeostasis1.64320546
30* MP0000609_abnormal_liver_physiology1.58784017
31MP0005503_abnormal_tendon_morphology1.43249080
32MP0004272_abnormal_basement_membrane1.37106213
33MP0005058_abnormal_lysosome_morphology1.35076938
34MP0005319_abnormal_enzyme/_coenzyme1.33647456
35MP0009764_decreased_sensitivity_to1.32889025
36MP0003724_increased_susceptibility_to1.28290539
37MP0005584_abnormal_enzyme/coenzyme_acti1.25823034
38MP0009643_abnormal_urine_homeostasis1.23770128
39MP0003566_abnormal_cell_adhesion1.22793720
40MP0003011_delayed_dark_adaptation1.22673286
41MP0002060_abnormal_skin_morphology1.20934828
42MP0001879_abnormal_lymphatic_vessel1.19708105
43MP0005636_abnormal_mineral_homeostasis1.18656618
44MP0005023_abnormal_wound_healing1.17150139
45MP0001542_abnormal_bone_strength1.15528397
46MP0005670_abnormal_white_adipose1.14121918
47MP0009053_abnormal_anal_canal1.14069808
48MP0000249_abnormal_blood_vessel1.13032408
49MP0002138_abnormal_hepatobiliary_system1.12051502
50MP0003195_calcinosis1.08373977
51MP0003436_decreased_susceptibility_to1.04153690
52MP0003186_abnormal_redox_activity1.03013845
53MP0001533_abnormal_skeleton_physiology1.02313408
54MP0002282_abnormal_trachea_morphology1.00465441
55MP0005464_abnormal_platelet_physiology0.99872114
56MP0003656_abnormal_erythrocyte_physiolo0.99624820
57MP0000681_abnormal_thyroid_gland0.99030775
58MP0000767_abnormal_smooth_muscle0.98053314
59MP0009785_altered_susceptibility_to0.97741680
60MP0000343_altered_response_to0.95465695
61MP0000598_abnormal_liver_morphology0.95077015
62MP0009763_increased_sensitivity_to0.93532120
63MP0010234_abnormal_vibrissa_follicle0.92301090
64MP0002132_abnormal_respiratory_system0.89932976
65* MP0008469_abnormal_protein_level0.87867385
66MP0003868_abnormal_feces_composition0.86612658
67MP0001764_abnormal_homeostasis0.85470394
68MP0002998_abnormal_bone_remodeling0.85305324
69MP0001661_extended_life_span0.83628692
70MP0005334_abnormal_fat_pad0.83072328
71MP0005666_abnormal_adipose_tissue0.81864202
72MP0009333_abnormal_splenocyte_physiolog0.81490757
73MP0000858_altered_metastatic_potential0.81467568
74MP0000639_abnormal_adrenal_gland0.80359867
75MP0005376_homeostasis/metabolism_phenot0.80080764
76MP0005187_abnormal_penis_morphology0.79975583
77MP0005167_abnormal_blood-brain_barrier0.77137238
78MP0009384_cardiac_valve_regurgitation0.77081448
79MP0005647_abnormal_sex_gland0.75520236
80MP0003300_gastrointestinal_ulcer0.75461880
81MP0000685_abnormal_immune_system0.75435504
82MP0005451_abnormal_body_composition0.74319212
83* MP0009642_abnormal_blood_homeostasis0.73106624
84MP0001756_abnormal_urination0.71646888
85* MP0002419_abnormal_innate_immunity0.71370777
86MP0003075_altered_response_to0.71349977
87MP0003690_abnormal_glial_cell0.71137318
88MP0002837_dystrophic_cardiac_calcinosis0.70871899
89MP0003329_amyloid_beta_deposits0.69579033
90MP0002136_abnormal_kidney_physiology0.69220341
91MP0005395_other_phenotype0.68354741
92MP0006082_CNS_inflammation0.68325582
93MP0009115_abnormal_fat_cell0.67646169
94MP0005408_hypopigmentation0.66711435
95MP0001765_abnormal_ion_homeostasis0.66229952
96MP0000627_abnormal_mammary_gland0.65732520
97MP0002168_other_aberrant_phenotype0.65394407
98MP0006036_abnormal_mitochondrial_physio0.64743332
99MP0004130_abnormal_muscle_cell0.63905611
100MP0001915_intracranial_hemorrhage0.62953352
101MP0003448_altered_tumor_morphology0.62861298
102MP0003567_abnormal_fetal_cardiomyocyte0.62724592
103MP0005375_adipose_tissue_phenotype0.61309560
104MP0002166_altered_tumor_susceptibility0.60638324
105MP0002135_abnormal_kidney_morphology0.59846293
106MP0005165_increased_susceptibility_to0.59358686
107MP0002876_abnormal_thyroid_physiology0.59063127
108MP0008874_decreased_physiological_sensi0.58495474
109MP0005508_abnormal_skeleton_morphology0.58339658
110MP0002796_impaired_skin_barrier0.57987417
111MP0008004_abnormal_stomach_pH0.57836249
112MP0002971_abnormal_brown_adipose0.57646399
113MP0004233_abnormal_muscle_weight0.57366212
114MP0004782_abnormal_surfactant_physiolog0.57322624
115MP0003638_abnormal_response/metabolism_0.57189699
116MP0004264_abnormal_extraembryonic_tissu0.57083960
117* MP0005025_abnormal_response_to0.56147512
118MP0002078_abnormal_glucose_homeostasis0.52720949
119MP0005535_abnormal_body_temperature0.51870721
120MP0010386_abnormal_urinary_bladder0.51422489
121MP0000920_abnormal_myelination0.50690211
122MP0005266_abnormal_metabolism0.47909530
123MP0003879_abnormal_hair_cell0.45214629
124MP0009765_abnormal_xenobiotic_induced0.43972097
125MP0002295_abnormal_pulmonary_circulatio0.43003755
126MP0002089_abnormal_postnatal_growth/wei0.41662175
127* MP0001845_abnormal_inflammatory_respons0.38699543
128MP0002249_abnormal_larynx_morphology0.36971447
129MP0003959_abnormal_lean_body0.36713144
130MP0000467_abnormal_esophagus_morphology0.35707449
131MP0001835_abnormal_antigen_presentation0.32932646
132MP0008872_abnormal_physiological_respon0.32202610
133MP0005397_hematopoietic_system_phenotyp0.31739645
134MP0001545_abnormal_hematopoietic_system0.31739645
135MP0000003_abnormal_adipose_tissue0.29942780
136MP0003878_abnormal_ear_physiology0.27816924
137MP0005377_hearing/vestibular/ear_phenot0.27816924
138* MP0005166_decreased_susceptibility_to0.27721521
139MP0003699_abnormal_female_reproductive0.27089063
140MP0001851_eye_inflammation0.26148831

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.27402196
2Complement deficiency (HP:0004431)5.32001606
3Systemic lupus erythematosus (HP:0002725)5.12004881
4Intrahepatic cholestasis (HP:0001406)5.02029973
5Prolonged partial thromboplastin time (HP:0003645)4.67807258
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.62234625
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.57366269
8Abnormality of pyrimidine metabolism (HP:0004353)4.38291122
9Xanthomatosis (HP:0000991)4.33655773
10Abnormality of the common coagulation pathway (HP:0010990)4.23545745
11Spontaneous abortion (HP:0005268)4.06201281
12Spondylolisthesis (HP:0003302)4.03180859
13Hyperlipoproteinemia (HP:0010980)3.93092381
14Abnormality of complement system (HP:0005339)3.90503854
15Joint hemorrhage (HP:0005261)3.89520618
16Hypobetalipoproteinemia (HP:0003563)3.74881471
17Aortic dissection (HP:0002647)3.73166811
18Purpura (HP:0000979)3.69867971
19Premature rupture of membranes (HP:0001788)3.48850600
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.45490597
21Hypoalphalipoproteinemia (HP:0003233)3.38532202
22Hypolipoproteinemia (HP:0010981)3.29756763
23Gingival bleeding (HP:0000225)3.27207587
24Aortic aneurysm (HP:0004942)3.23678692
25Myocardial infarction (HP:0001658)3.13446546
26Abnormal gallbladder physiology (HP:0012438)3.12486286
27Cholecystitis (HP:0001082)3.12486286
28Abnormality of the intrinsic pathway (HP:0010989)3.10403411
29Osteolytic defects of the phalanges of the hand (HP:0009771)3.08747168
30Osteolytic defects of the hand bones (HP:0009699)3.08747168
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.08137098
32Conjugated hyperbilirubinemia (HP:0002908)3.05610664
33Glomerulonephritis (HP:0000099)3.02562663
34Cerebral aneurysm (HP:0004944)2.94198024
35Abnormality of proline metabolism (HP:0010907)2.90563128
36Hydroxyprolinuria (HP:0003080)2.90563128
37Ulnar bowing (HP:0003031)2.89148496
38Follicular hyperkeratosis (HP:0007502)2.89011093
39Arterial tortuosity (HP:0005116)2.86005300
40Epidermoid cyst (HP:0200040)2.82703421
41Alopecia of scalp (HP:0002293)2.82525495
42Hyperammonemia (HP:0001987)2.82476229
43Fat malabsorption (HP:0002630)2.75798020
44Abnormality of purine metabolism (HP:0004352)2.70290623
45Nephritis (HP:0000123)2.68685812
46Malnutrition (HP:0004395)2.65208727
47Vascular tortuosity (HP:0004948)2.64921849
48Abnormal cartilage morphology (HP:0002763)2.60737637
49Mucopolysacchariduria (HP:0008155)2.57281641
50Urinary glycosaminoglycan excretion (HP:0003541)2.57281641
51Menorrhagia (HP:0000132)2.56865621
52Ketosis (HP:0001946)2.56091137
53Abnormal delivery (HP:0001787)2.55656977
54Amyloidosis (HP:0011034)2.54192461
55Abnormality of sulfur amino acid metabolism (HP:0004339)2.51567327
56Hyperbilirubinemia (HP:0002904)2.50057820
57Absent frontal sinuses (HP:0002688)2.47572379
58Reduced antithrombin III activity (HP:0001976)2.46398205
59Hypoglycemic coma (HP:0001325)2.46331178
60Skin nodule (HP:0200036)2.45670061
61Right ventricular cardiomyopathy (HP:0011663)2.44927371
62Hypercholesterolemia (HP:0003124)2.42996943
63Delayed closure of the anterior fontanelle (HP:0001476)2.40388804
64Abnormality of nucleobase metabolism (HP:0010932)2.40046795
65Abnormality of polysaccharide metabolism (HP:0011012)2.39165596
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.39165596
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.39165596
68Broad metatarsal (HP:0001783)2.33907712
69Radial bowing (HP:0002986)2.33416569
70Spastic diplegia (HP:0001264)2.33081797
71Cholelithiasis (HP:0001081)2.33057340
72Pulmonary embolism (HP:0002204)2.30276660
73Osteomalacia (HP:0002749)2.29464692
74Cardiovascular calcification (HP:0011915)2.27637759
75Vascular calcification (HP:0004934)2.26858938
76Dysostosis multiplex (HP:0000943)2.24907963
77Esophageal varix (HP:0002040)2.24446211
78Protrusio acetabuli (HP:0003179)2.24284602
79Joint swelling (HP:0001386)2.23759485
80Hyperglycinemia (HP:0002154)2.23618521
81Peritonitis (HP:0002586)2.23310151
82Persistence of primary teeth (HP:0006335)2.23294445
83Hyperglycinuria (HP:0003108)2.22717498
84Abnormality of methionine metabolism (HP:0010901)2.22549468
85Abnormality of fatty-acid metabolism (HP:0004359)2.20996980
86Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18635256
87Generalized aminoaciduria (HP:0002909)2.18329460
88Cervical subluxation (HP:0003308)2.16640874
89Bowed forearm bones (HP:0003956)2.15979730
90Bowing of the arm (HP:0006488)2.15979730
91Delayed CNS myelination (HP:0002188)2.14522227
92Abnormal gallbladder morphology (HP:0012437)2.13895636
93Hepatocellular carcinoma (HP:0001402)2.13213112
94Petechiae (HP:0000967)2.12337112
95Abnormality of glycine metabolism (HP:0010895)2.11911756
96Abnormality of serine family amino acid metabolism (HP:0010894)2.11911756
97Ankle contracture (HP:0006466)2.10516004
98Blue sclerae (HP:0000592)2.10002153
99Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.09670124
100Vacuolated lymphocytes (HP:0001922)2.07668601
101Abnormality of iron homeostasis (HP:0011031)2.07608547
102Rickets (HP:0002748)2.07139666
103Recurrent gram-negative bacterial infections (HP:0005420)2.06069346
104Arthropathy (HP:0003040)2.06001878
105Asymmetric septal hypertrophy (HP:0001670)2.04677732
106Neonatal hypoglycemia (HP:0001998)2.01687808
107Elevated alkaline phosphatase (HP:0003155)2.01599539
108Gangrene (HP:0100758)2.01392321
109Abnormality of serum amino acid levels (HP:0003112)2.00661537
110Hemorrhage of the eye (HP:0011885)2.00488636
111Thrombophlebitis (HP:0004418)2.00388463
112Increased mean platelet volume (HP:0011877)2.00375318
113Steatorrhea (HP:0002570)2.00181095
114Mitral stenosis (HP:0001718)1.99976245
115Pancreatitis (HP:0001733)1.99842796
116Abnormality of transition element cation homeostasis (HP:0011030)1.99840131
117Polycythemia (HP:0001901)1.98460237
118Gout (HP:0001997)1.97117290
119Mitral valve prolapse (HP:0001634)1.96604216
120Bifid scrotum (HP:0000048)1.95085440
121Increased serum ferritin (HP:0003281)1.94283015
122Abnormal enzyme/coenzyme activity (HP:0012379)1.84864972
123Abnormality of alkaline phosphatase activity (HP:0004379)1.83949666
124Optic neuritis (HP:0100653)1.77822428
125Retrobulbar optic neuritis (HP:0100654)1.77822428
126Bile duct proliferation (HP:0001408)1.77192595
127Abnormal biliary tract physiology (HP:0012439)1.77192595
128Fair hair (HP:0002286)1.76886373
129Metabolic acidosis (HP:0001942)1.70792351
130Epistaxis (HP:0000421)1.70225384
131Orchitis (HP:0100796)1.64740938
132Diaphragmatic weakness (HP:0009113)1.63128915
133Poikilocytosis (HP:0004447)1.62803535
134Hyperphosphaturia (HP:0003109)1.58673772
135Irritability (HP:0000737)1.58602123
136Abnormality of the gallbladder (HP:0005264)1.56301746
137Anorexia (HP:0002039)1.53071253
138Chin dimple (HP:0010751)1.49936273
139Increased serum pyruvate (HP:0003542)1.49667078
140Abnormality of dental color (HP:0011073)1.49519801
141Abnormality of urine glucose concentration (HP:0011016)1.45224436
142Glycosuria (HP:0003076)1.45224436
143Hand muscle atrophy (HP:0009130)1.44257263
144Periodontitis (HP:0000704)1.41565165

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.98290367
2TGFBR24.63803507
3MAP3K23.70358410
4SIK13.70121512
5BRSK23.33934320
6MYLK3.10462079
7BCKDK3.08266468
8FGFR42.90294893
9BMPR22.81402439
10WEE12.58593524
11TAOK32.44249974
12TRIB32.39913032
13MST1R2.36946151
14EPHB12.24822379
15TTN2.04750643
16PIK3CG2.03265506
17TIE12.00443286
18NME11.98685097
19EPHA31.89369636
20FLT31.84414876
21KDR1.79464579
22PKN21.74017646
23GRK51.70703696
24NEK91.67793236
25NEK11.66702622
26MAP2K31.63758469
27PTK61.63071731
28RIPK11.61703591
29LATS11.53159758
30TYK21.51921173
31PDGFRA1.45692533
32TRPM71.37166227
33MAP3K121.34479353
34IRAK31.34334839
35EPHB21.34292262
36ICK1.32745059
37EIF2AK21.31824526
38IRAK21.30055158
39LATS21.27523746
40KIT1.26576543
41PRKACG1.25952627
42TNK21.21899890
43MAPKAPK31.20748299
44DDR21.17519603
45MET1.12193739
46JAK11.11697896
47FER1.10593210
48MAP3K31.09668801
49PBK1.08714631
50BRSK11.06487103
51FGFR21.05869204
52EIF2AK31.04413801
53ZAP701.03397379
54EPHA21.02144274
55PAK21.01852672
56BRAF1.00862566
57PAK40.99915366
58MAPK120.97414126
59NLK0.97218676
60TBK10.95474759
61CAMK1D0.94386681
62ERBB20.93048059
63MAPK150.92521706
64STK160.91249251
65INSRR0.89714093
66MAP3K100.88940905
67PTK20.86769574
68FGFR30.86754128
69LRRK20.86189858
70MAP3K70.85436721
71TESK20.85123059
72JAK30.83751406
73EIF2AK10.80860459
74IRAK10.80059159
75ABL20.78848658
76MAP3K140.77877948
77MAPK110.77747057
78BUB10.77485466
79JAK20.76951169
80PRKAA20.74803386
81MAPK40.74392880
82GSK3A0.73848783
83FRK0.70276728
84CSK0.69095171
85ERBB40.68774579
86NTRK10.68103110
87PRKCG0.67800675
88CSNK2A10.64095766
89MAP2K60.63858638
90TSSK60.63516221
91TGFBR10.62500075
92BMX0.61808866
93CSNK1A10.59958614
94STK30.59745430
95MAP2K20.59402029
96IKBKE0.58954404
97NTRK30.57448150
98PDK20.57279123
99BCR0.56267603
100CSNK2A20.54629683
101CDK60.53689594
102PDPK10.53657743
103MAP3K80.53540933
104PRKG10.52458951
105IKBKB0.51913006
106MAP3K60.51723023
107IGF1R0.50423653
108CAMK2G0.50420337
109CAMK1G0.50210499
110PTK2B0.49459191
111TEC0.48645248
112TTK0.48438071
113PDGFRB0.48127485
114PIK3CA0.47742528
115RPS6KA30.46086224
116STK100.44841166
117DAPK20.44758222
118BLK0.44477418
119PRKACB0.44266103
120MAP2K10.42604177
121DMPK0.40972600
122RET0.39276588
123PRKCZ0.39006386
124RPS6KB20.38747202
125MAP3K10.38745198
126BTK0.37784233
127MAP2K40.37621452
128TESK10.37509932
129LMTK20.37448108
130EEF2K0.37364938
131HCK0.37276427
132ITK0.36076365
133PRKACA0.36062441
134ARAF0.35832050
135ABL10.35387035
136MARK30.35243207
137SRC0.34819682
138PRKCB0.34644793
139RPS6KA20.33911173
140MAPK70.33503768
141RPS6KC10.32119586
142RPS6KL10.32119586
143RPS6KA60.31698943
144EGFR0.30202943
145STK38L0.30134771
146CSNK1E0.28703229
147PRKAA10.28623869
148PRKCI0.27667813
149PRKCA0.24601421
150FGFR10.22587181
151OBSCN0.21296181
152ADRBK10.20490820
153RPS6KA50.19000007

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.84725396
2Complement and coagulation cascades_Homo sapiens_hsa046103.70019553
3Nitrogen metabolism_Homo sapiens_hsa009103.60556910
4Caffeine metabolism_Homo sapiens_hsa002323.34409172
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.80858416
6Staphylococcus aureus infection_Homo sapiens_hsa051502.70130974
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67484989
8Arginine biosynthesis_Homo sapiens_hsa002202.50236058
9Tryptophan metabolism_Homo sapiens_hsa003802.35127216
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32934483
11Fatty acid degradation_Homo sapiens_hsa000712.29350847
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21441347
13Histidine metabolism_Homo sapiens_hsa003402.18267861
14PPAR signaling pathway_Homo sapiens_hsa033202.16028922
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96186172
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.91837895
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90550150
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.89126199
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.87895151
20Chemical carcinogenesis_Homo sapiens_hsa052041.85244966
21Peroxisome_Homo sapiens_hsa041461.82000165
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.80638162
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80567082
24Fatty acid metabolism_Homo sapiens_hsa012121.64165778
25Retinol metabolism_Homo sapiens_hsa008301.54234816
26Propanoate metabolism_Homo sapiens_hsa006401.50256764
27beta-Alanine metabolism_Homo sapiens_hsa004101.47662855
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.42382173
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.42225873
30Starch and sucrose metabolism_Homo sapiens_hsa005001.38365292
31Butanoate metabolism_Homo sapiens_hsa006501.33674815
32Glutathione metabolism_Homo sapiens_hsa004801.32399049
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31200257
34Bile secretion_Homo sapiens_hsa049761.29229459
35Phenylalanine metabolism_Homo sapiens_hsa003601.24452084
36ABC transporters_Homo sapiens_hsa020101.21627830
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19560196
38Fatty acid elongation_Homo sapiens_hsa000621.11935724
39Tyrosine metabolism_Homo sapiens_hsa003501.11341246
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09569217
41Sulfur metabolism_Homo sapiens_hsa009201.08340244
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06103152
43Fat digestion and absorption_Homo sapiens_hsa049751.03622765
44Selenocompound metabolism_Homo sapiens_hsa004501.02033142
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01809437
46Pentose phosphate pathway_Homo sapiens_hsa000300.97281455
47Arginine and proline metabolism_Homo sapiens_hsa003300.95466952
48Pyruvate metabolism_Homo sapiens_hsa006200.94341033
49Sulfur relay system_Homo sapiens_hsa041220.93027179
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88988955
51Vitamin digestion and absorption_Homo sapiens_hsa049770.87298972
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85181818
53Folate biosynthesis_Homo sapiens_hsa007900.83708755
54Galactose metabolism_Homo sapiens_hsa000520.83707216
55Biosynthesis of amino acids_Homo sapiens_hsa012300.82528635
56One carbon pool by folate_Homo sapiens_hsa006700.81917216
57Carbon metabolism_Homo sapiens_hsa012000.79960047
58Lysosome_Homo sapiens_hsa041420.78757246
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.76577223
60Fatty acid biosynthesis_Homo sapiens_hsa000610.76058533
61Other glycan degradation_Homo sapiens_hsa005110.74109146
62ECM-receptor interaction_Homo sapiens_hsa045120.73811407
63Lysine degradation_Homo sapiens_hsa003100.70745452
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68702496
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66281137
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63462757
67Glycerolipid metabolism_Homo sapiens_hsa005610.62443160
68Pertussis_Homo sapiens_hsa051330.57671786
69Arachidonic acid metabolism_Homo sapiens_hsa005900.57575027
70Amoebiasis_Homo sapiens_hsa051460.55401495
71Steroid biosynthesis_Homo sapiens_hsa001000.51751555
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48222266
73Systemic lupus erythematosus_Homo sapiens_hsa053220.47804886
74Prion diseases_Homo sapiens_hsa050200.44287015
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.44207995
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43271558
77Vitamin B6 metabolism_Homo sapiens_hsa007500.40315615
78Insulin resistance_Homo sapiens_hsa049310.38195054
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.37551851
80Malaria_Homo sapiens_hsa051440.32978075
81Metabolic pathways_Homo sapiens_hsa011000.31656315
82Thyroid hormone synthesis_Homo sapiens_hsa049180.29060067
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28491037
84Sphingolipid metabolism_Homo sapiens_hsa006000.28097319
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27456492
86Focal adhesion_Homo sapiens_hsa045100.25878844
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24715186
88TGF-beta signaling pathway_Homo sapiens_hsa043500.24328443
89Osteoclast differentiation_Homo sapiens_hsa043800.21451712
90Phagosome_Homo sapiens_hsa041450.20886553
91Hematopoietic cell lineage_Homo sapiens_hsa046400.20221374
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20088852
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19273633
94Leishmaniasis_Homo sapiens_hsa051400.18266879
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17910541
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14371781
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13750895
98Renin-angiotensin system_Homo sapiens_hsa046140.13740220
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.13042180
100Fructose and mannose metabolism_Homo sapiens_hsa000510.12673698
101Proteoglycans in cancer_Homo sapiens_hsa052050.11395459
102Ovarian steroidogenesis_Homo sapiens_hsa049130.10099747
103N-Glycan biosynthesis_Homo sapiens_hsa005100.08757091
104Toxoplasmosis_Homo sapiens_hsa051450.08536846
105Linoleic acid metabolism_Homo sapiens_hsa005910.07934111
106Rheumatoid arthritis_Homo sapiens_hsa053230.07413626
107Glucagon signaling pathway_Homo sapiens_hsa049220.05431855
108Influenza A_Homo sapiens_hsa051640.01841768
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321-0.1867764
110Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1862829
111Herpes simplex infection_Homo sapiens_hsa05168-0.1727091
112Antigen processing and presentation_Homo sapiens_hsa04612-0.1643840
113Insulin signaling pathway_Homo sapiens_hsa04910-0.1628617
114Jak-STAT signaling pathway_Homo sapiens_hsa04630-0.1608865
115Circadian rhythm_Homo sapiens_hsa04710-0.1595397
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1520035
117Hepatitis C_Homo sapiens_hsa05160-0.1193852
118Mineral absorption_Homo sapiens_hsa04978-0.0721845
119Serotonergic synapse_Homo sapiens_hsa04726-0.0720084
120AMPK signaling pathway_Homo sapiens_hsa04152-0.0638565
121Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0407756
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0270143
123African trypanosomiasis_Homo sapiens_hsa05143-0.0062361

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