LBX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-mediated cell contraction (GO:0070252)9.71111127
2sarcoplasmic reticulum calcium ion transport (GO:0070296)9.26779027
3skeletal muscle adaptation (GO:0043501)9.15212980
4skeletal muscle fiber development (GO:0048741)8.95323047
5myotube cell development (GO:0014904)7.56828951
6actin filament-based movement (GO:0030048)7.33747731
7plasma membrane repair (GO:0001778)7.14213241
8striated muscle atrophy (GO:0014891)6.56256030
9response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.26930154
10sarcomere organization (GO:0045214)6.14642102
11skeletal muscle tissue regeneration (GO:0043403)6.10896341
12striated muscle contraction (GO:0006941)6.09745018
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.97482968
14response to inactivity (GO:0014854)5.65212706
15muscle atrophy (GO:0014889)5.59459209
16response to muscle activity (GO:0014850)5.56914874
17purine nucleotide salvage (GO:0032261)5.43089203
18glycogen catabolic process (GO:0005980)5.42713274
19myofibril assembly (GO:0030239)5.41786671
20muscle fiber development (GO:0048747)5.28612712
21creatine metabolic process (GO:0006600)5.24004172
22striated muscle adaptation (GO:0014888)5.15009394
23muscle contraction (GO:0006936)5.12374201
24glucan catabolic process (GO:0009251)5.05207582
25carnitine shuttle (GO:0006853)4.96123968
26regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.94793924
27muscle organ morphogenesis (GO:0048644)4.93550132
28IMP metabolic process (GO:0046040)4.89288977
29cellular polysaccharide catabolic process (GO:0044247)4.65837156
30negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.63722018
31muscle cell fate commitment (GO:0042693)4.60333747
32muscle system process (GO:0003012)4.56584292
33regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.51303917
34positive regulation of myotube differentiation (GO:0010831)4.48238537
35regulation of cell communication by electrical coupling (GO:0010649)4.48071923
36myotube differentiation (GO:0014902)4.43231269
37polysaccharide catabolic process (GO:0000272)4.41451619
38pyrimidine ribonucleoside catabolic process (GO:0046133)4.32212552
39actomyosin structure organization (GO:0031032)4.31367524
40glucan biosynthetic process (GO:0009250)4.26657033
41glycogen biosynthetic process (GO:0005978)4.26657033
42neuronal action potential propagation (GO:0019227)4.22194509
43striated muscle cell development (GO:0055002)4.14690031
44muscle adaptation (GO:0043500)4.09640575
45regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.09547610
46positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.04374174
47muscle cell cellular homeostasis (GO:0046716)4.02888815
48cytidine metabolic process (GO:0046087)4.02340790
49cytidine catabolic process (GO:0006216)4.02340790
50cytidine deamination (GO:0009972)4.02340790
51fatty acid transmembrane transport (GO:1902001)4.00741487
52cardiac muscle hypertrophy (GO:0003300)4.00312572
53regulation of actin filament-based movement (GO:1903115)3.95991622
54neuromuscular synaptic transmission (GO:0007274)3.94441521
55myoblast fusion (GO:0007520)3.91575555
56regulation of skeletal muscle cell differentiation (GO:2001014)3.83317226
57striated muscle hypertrophy (GO:0014897)3.81114250
58DNA damage induced protein phosphorylation (GO:0006975)3.76287615
59skeletal muscle tissue development (GO:0007519)3.76124268
60fructose metabolic process (GO:0006000)3.75670896
61* muscle organ development (GO:0007517)3.72623750
62gluconeogenesis (GO:0006094)3.71802620
63* muscle structure development (GO:0061061)3.70029214
64glycogen metabolic process (GO:0005977)3.68868928
65muscle tissue morphogenesis (GO:0060415)3.66858417
66adult heart development (GO:0007512)3.66846580
67NADH metabolic process (GO:0006734)3.66573565
68negative regulation of skeletal muscle tissue development (GO:0048642)3.65141799
69regulation of acyl-CoA biosynthetic process (GO:0050812)3.65106910
70regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.65011633
71glucan metabolic process (GO:0044042)3.60587635
72cellular glucan metabolic process (GO:0006073)3.60587635
73response to activity (GO:0014823)3.58181380
74muscle cell development (GO:0055001)3.57815716
75IMP biosynthetic process (GO:0006188)3.57478326
76negative regulation of potassium ion transmembrane transport (GO:1901380)3.57095884
77carnitine transmembrane transport (GO:1902603)3.54203287
78regulation of striated muscle contraction (GO:0006942)3.45706013
79syncytium formation by plasma membrane fusion (GO:0000768)3.45261739
80positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.44531095
81syncytium formation (GO:0006949)3.41814817
82positive regulation of myoblast differentiation (GO:0045663)3.41144718
83negative regulation of muscle hypertrophy (GO:0014741)3.40305402
84cranial nerve morphogenesis (GO:0021602)3.39014012
85cytoplasmic microtubule organization (GO:0031122)3.38503785
86negative regulation of cAMP-mediated signaling (GO:0043951)3.33114582
87hexose biosynthetic process (GO:0019319)3.32487901
88muscle hypertrophy (GO:0014896)3.31943379
89regulation of calcium ion transmembrane transport (GO:1903169)3.31452531
90cardiac muscle cell development (GO:0055013)3.31440760
91cardiac muscle tissue morphogenesis (GO:0055008)3.30841801
92negative regulation of nitric-oxide synthase activity (GO:0051001)3.29714559
93AMP metabolic process (GO:0046033)3.29653234
94neuromuscular junction development (GO:0007528)3.28647904
95respiratory system process (GO:0003016)3.28612542
962-oxoglutarate metabolic process (GO:0006103)3.28280966
97regulation of cofactor metabolic process (GO:0051193)3.22623067
98regulation of coenzyme metabolic process (GO:0051196)3.22623067
99striated muscle tissue development (GO:0014706)3.21682555
100amino-acid betaine transport (GO:0015838)3.21062809
101carnitine transport (GO:0015879)3.21062809
102negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.19975067
103negative regulation of calcium ion transmembrane transport (GO:1903170)3.19975067
104membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16452909
105cardiac muscle adaptation (GO:0014887)3.16362257
106cardiac muscle hypertrophy in response to stress (GO:0014898)3.16362257
107muscle hypertrophy in response to stress (GO:0003299)3.16362257
108regulation of sarcomere organization (GO:0060297)3.16012405
109regulation of membrane repolarization (GO:0060306)3.15515761
110cardiac muscle contraction (GO:0060048)3.13861933
111negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.11095653
112regulation of myotube differentiation (GO:0010830)3.09725451
113ubiquinone biosynthetic process (GO:0006744)3.09559522
114cardiac cell development (GO:0055006)3.08999400
115cardiac myofibril assembly (GO:0055003)3.06374015
116skeletal muscle cell differentiation (GO:0035914)3.04361806
117positive regulation of cation channel activity (GO:2001259)3.02753212
118regulation of myoblast differentiation (GO:0045661)3.02723328
119oxidative phosphorylation (GO:0006119)3.02128075
120negative regulation of cell size (GO:0045792)2.95280875
121regulation of relaxation of muscle (GO:1901077)2.93986802
122cellular carbohydrate catabolic process (GO:0044275)2.93908606
123cellular response to dexamethasone stimulus (GO:0071549)2.83228957
124heart contraction (GO:0060047)2.80268686
125heart process (GO:0003015)2.80268686
126intracellular lipid transport (GO:0032365)2.80199019
127regulation of sulfur metabolic process (GO:0042762)2.78909782
128regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.74641870
129regulation of calcium ion transmembrane transporter activity (GO:1901019)2.71432026
130actin-myosin filament sliding (GO:0033275)11.5981417
131muscle filament sliding (GO:0030049)11.5981417
132skeletal muscle contraction (GO:0003009)10.9165404
133regulation of skeletal muscle contraction (GO:0014819)10.8200704

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.36954827
2ESR1_20079471_ChIP-ChIP_T-47D_Human4.21552047
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.18038296
4* CBX2_27304074_Chip-Seq_ESCs_Mouse3.05542026
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.05255108
6* EZH2_27304074_Chip-Seq_ESCs_Mouse2.83382580
7* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64214733
8* EZH2_27294783_Chip-Seq_ESCs_Mouse2.62658552
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55849042
10BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.55346077
11* TP53_20018659_ChIP-ChIP_R1E_Mouse2.39725017
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.38894689
13* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.37781866
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33887141
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33887141
16* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31951579
17* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.29893821
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27568281
19TBX20_22328084_ChIP-Seq_HEART_Mouse2.17104007
20TBX20_22080862_ChIP-Seq_HEART_Mouse2.17104007
21ZNF263_19887448_ChIP-Seq_K562_Human2.15093217
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.14800817
23MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.13976164
24CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12283873
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05974564
26* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00536767
27* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.87532270
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86330633
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.86219880
30* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83489716
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.81276655
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78237862
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77393632
34* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76733032
35CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.76628371
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73930494
37* RNF2_27304074_Chip-Seq_ESCs_Mouse1.70815527
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69963807
39CTCF_21964334_ChIP-Seq_BJAB-B_Human1.69205615
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.67901208
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66528245
42* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64808560
43* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62508150
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62307861
45KDM2B_26808549_Chip-Seq_DND41_Human1.60932820
46ATF3_27146783_Chip-Seq_COLON_Human1.60605099
47* RNF2_27304074_Chip-Seq_NSC_Mouse1.54494664
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.54163401
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.49242138
50TDRD3_21172665_ChIP-Seq_MCF-7_Human1.49035792
51CREB1_26743006_Chip-Seq_LNCaP_Human1.47692116
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46129976
53AR_21572438_ChIP-Seq_LNCaP_Human1.45795815
54CTCF_27219007_Chip-Seq_Bcells_Human1.45654951
55* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.44692845
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.43207263
57ZNF274_21170338_ChIP-Seq_K562_Hela1.40404595
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38775189
59IGF1R_20145208_ChIP-Seq_DFB_Human1.38145922
60* RING1B_27294783_Chip-Seq_NPCs_Mouse1.37701338
61* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36537043
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36198120
63* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.35261126
64CTCF_21964334_Chip-Seq_Bcells_Human1.34903691
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33591392
66GATA4_21415370_ChIP-Seq_HL-1_Mouse1.32432148
67* KDM2B_26808549_Chip-Seq_K562_Human1.29977577
68* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29468839
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.28655780
70* TCF7_22412390_ChIP-Seq_EML_Mouse1.27244807
71* RING1B_27294783_Chip-Seq_ESCs_Mouse1.26827706
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26589780
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26527394
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23945266
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.23114911
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22135779
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21893129
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21150860
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20888581
80* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20449564
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20122284
82* SA1_27219007_Chip-Seq_Bcells_Human1.18636094
83EZH2_22144423_ChIP-Seq_EOC_Human1.18174982
84LXR_22292898_ChIP-Seq_THP-1_Human1.17808978
85DROSHA_22980978_ChIP-Seq_HELA_Human1.16404563
86* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15614607
87* TET1_21451524_ChIP-Seq_MESCs_Mouse1.14884488
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14187556
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.13961403
90AR_21909140_ChIP-Seq_LNCAP_Human1.12936744
91OCT4_20526341_ChIP-Seq_ESCs_Human1.11676053
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10821828
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.10676255
94GATA6_21074721_ChIP-Seq_CACO-2_Human1.09310934
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09294288
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09195652
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09094032
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08472770
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07949160
100OCT1_27270436_Chip-Seq_PROSTATE_Human1.07805178
101STAT1_20625510_ChIP-Seq_HELA_Human1.07727099
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06710879
103EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06140329
104* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05744288
105YY1_22570637_ChIP-Seq_MALME-3M_Human1.05411582
106ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04908969
107NANOG_21062744_ChIP-ChIP_HESCs_Human1.04741123
108* REST_18959480_ChIP-ChIP_MESCs_Mouse1.04485097
109SA1_27219007_Chip-Seq_ERYTHROID_Human1.04197868
110P68_20966046_ChIP-Seq_HELA_Human1.03313700
111SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03016554
112RACK7_27058665_Chip-Seq_MCF-7_Human1.00424227
113ISL1_27105846_Chip-Seq_CPCs_Mouse1.00399071
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00142304
115GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00028841
116KLF4_19829295_ChIP-Seq_ESCs_Human0.99485301
117FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99308777
118FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99269755
119SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97897887
120RAC3_21632823_ChIP-Seq_H3396_Human0.97780019
121* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97081505
122CJUN_26792858_Chip-Seq_BT549_Human0.95995415
123SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95909312
124SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93975175
125FOXH1_21741376_ChIP-Seq_EPCs_Human0.93743161
126RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92932400
127SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92718058
128YY1_21170310_ChIP-Seq_MESCs_Mouse0.92439142
129SPI1_20517297_ChIP-Seq_HL60_Human0.91897559
130RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91834828
131GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.91507650
132NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91489417
133AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91471370
134ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91441739
135* NANOG_20526341_ChIP-Seq_ESCs_Human0.90993392
136ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90139589
137NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89084355
138* FOXH1_21741376_ChIP-Seq_ESCs_Human0.87853536
139NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87154551
140SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86882504
141WDR5_24793694_ChIP-Seq_LNCAP_Human0.86635636
142DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86087570
143UBF1/2_26484160_Chip-Seq_HMECs_Human0.84315364
144* OCT4_19829295_ChIP-Seq_ESCs_Human0.83689067
145CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83421641
146GATA3_21867929_ChIP-Seq_CD8_Mouse0.83313870
147* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.83290175
148* MYC_27129775_Chip-Seq_CORNEA_Mouse0.82994827
149E2F1_20622854_ChIP-Seq_HELA_Human0.82162544
150DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82028367
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81843368
152CBP_20019798_ChIP-Seq_JUKART_Human0.81843368
153* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80602435
154* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79781839
155TBL1_22424771_ChIP-Seq_293T_Human0.78851774
156LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.78650392
157BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77056987
158CTCF_26484167_Chip-Seq_Bcells_Mouse0.76992436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio7.85611533
2MP0003646_muscle_fatigue6.96785275
3MP0000749_muscle_degeneration5.90128228
4MP0000751_myopathy5.33710547
5MP0002822_catalepsy4.79737393
6MP0000747_muscle_weakness4.28718646
7MP0002106_abnormal_muscle_physiology4.26572239
8MP0000750_abnormal_muscle_regeneration3.77768059
9* MP0000759_abnormal_skeletal_muscle3.69481792
10MP0005369_muscle_phenotype3.51517277
11MP0004036_abnormal_muscle_relaxation3.47522297
12MP0002269_muscular_atrophy3.44275579
13MP0004087_abnormal_muscle_fiber3.32421065
14MP0005620_abnormal_muscle_contractility2.82043753
15* MP0000733_abnormal_muscle_development2.78826632
16MP0004233_abnormal_muscle_weight2.75903042
17MP0002837_dystrophic_cardiac_calcinosis2.71368826
18MP0004130_abnormal_muscle_cell2.54568539
19MP0004185_abnormal_adipocyte_glucose2.19324429
20MP0002332_abnormal_exercise_endurance2.11590958
21MP0004270_analgesia2.01260534
22MP0002108_abnormal_muscle_morphology1.96026489
23MP0005451_abnormal_body_composition1.65037330
24MP0005330_cardiomyopathy1.47266830
25MP0002971_abnormal_brown_adipose1.44475794
26MP0006036_abnormal_mitochondrial_physio1.39496146
27MP0003221_abnormal_cardiomyocyte_apopto1.34437354
28MP0005666_abnormal_adipose_tissue1.33148124
29MP0009250_abnormal_appendicular_skeleto1.27369266
30MP0004084_abnormal_cardiac_muscle1.24606336
31MP0003950_abnormal_plasma_membrane1.21997393
32MP0001299_abnormal_eye_distance/1.18136581
33MP0004215_abnormal_myocardial_fiber1.13022564
34MP0010630_abnormal_cardiac_muscle1.05387636
35MP0004484_altered_response_of1.02786813
36MP0002972_abnormal_cardiac_muscle0.98036520
37MP0003705_abnormal_hypodermis_morpholog0.97721406
38MP0005375_adipose_tissue_phenotype0.94863159
39MP0005266_abnormal_metabolism0.91375350
40MP0001849_ear_inflammation0.89083621
41MP0002735_abnormal_chemical_nociception0.85728698
42MP0010030_abnormal_orbit_morphology0.83255833
43MP0005670_abnormal_white_adipose0.82932936
44MP0002249_abnormal_larynx_morphology0.82137317
45MP0002653_abnormal_ependyma_morphology0.81372031
46MP0002114_abnormal_axial_skeleton0.78335932
47MP0005257_abnormal_intraocular_pressure0.74018848
48MP0003755_abnormal_palate_morphology0.73488344
49MP0001346_abnormal_lacrimal_gland0.72257003
50MP0000049_abnormal_middle_ear0.71720490
51MP0001661_extended_life_span0.70552132
52MP0002234_abnormal_pharynx_morphology0.68420048
53MP0000003_abnormal_adipose_tissue0.67778802
54MP0005423_abnormal_somatic_nervous0.67630870
55MP0003137_abnormal_impulse_conducting0.67389309
56MP0004134_abnormal_chest_morphology0.66454869
57MP0003879_abnormal_hair_cell0.65906262
58MP0003385_abnormal_body_wall0.65509298
59* MP0000955_abnormal_spinal_cord0.65432322
60MP0000013_abnormal_adipose_tissue0.65202908
61MP0003656_abnormal_erythrocyte_physiolo0.64842580
62MP0005623_abnormal_meninges_morphology0.64636967
63MP0006035_abnormal_mitochondrial_morpho0.64153396
64MP0000762_abnormal_tongue_morphology0.64123041
65MP0004924_abnormal_behavior0.64043243
66MP0005386_behavior/neurological_phenoty0.64043243
67MP0000534_abnormal_ureter_morphology0.63323702
68MP0001544_abnormal_cardiovascular_syste0.63160324
69MP0005385_cardiovascular_system_phenoty0.63160324
70MP0002932_abnormal_joint_morphology0.62766202
71MP0009672_abnormal_birth_weight0.62293504
72MP0002184_abnormal_innervation0.61923292
73MP0003718_maternal_effect0.61693043
74MP0000678_abnormal_parathyroid_gland0.61203632
75MP0001529_abnormal_vocalization0.58172881
76MP0002733_abnormal_thermal_nociception0.55771109
77MP0002877_abnormal_melanocyte_morpholog0.54429124
78* MP0000266_abnormal_heart_morphology0.53731091
79MP0008961_abnormal_basal_metabolism0.52415757
80MP0004085_abnormal_heartbeat0.51835960
81MP0003937_abnormal_limbs/digits/tail_de0.51668113
82MP0005167_abnormal_blood-brain_barrier0.50662212
83MP0008775_abnormal_heart_ventricle0.50236937
84MP0000579_abnormal_nail_morphology0.49847200
85MP0000372_irregular_coat_pigmentation0.49347825
86MP0005187_abnormal_penis_morphology0.49210649
87MP0002734_abnormal_mechanical_nocicepti0.48734766
88MP0002127_abnormal_cardiovascular_syste0.48648797
89MP0001943_abnormal_respiration0.48120950
90MP0002067_abnormal_sensory_capabilities0.47892231
91MP0005076_abnormal_cell_differentiation0.47531220
92MP0001440_abnormal_grooming_behavior0.47515473
93MP0003635_abnormal_synaptic_transmissio0.46202519
94MP0005452_abnormal_adipose_tissue0.45438102
95MP0009780_abnormal_chondrocyte_physiolo0.45080423
96MP0003283_abnormal_digestive_organ0.42562655
97MP0004858_abnormal_nervous_system0.41207796
98MP0004147_increased_porphyrin_level0.40376136
99MP0003828_pulmonary_edema0.39683683
100MP0006276_abnormal_autonomic_nervous0.39238944
101* MP0002081_perinatal_lethality0.38643406
102MP0002078_abnormal_glucose_homeostasis0.38052939
103MP0003567_abnormal_fetal_cardiomyocyte0.36630592
104MP0006138_congestive_heart_failure0.36380107
105MP0003806_abnormal_nucleotide_metabolis0.35996709
106* MP0002752_abnormal_somatic_nervous0.35955072
107MP0004859_abnormal_synaptic_plasticity0.35879368
108MP0008569_lethality_at_weaning0.35532185
109MP0002084_abnormal_developmental_patter0.35008859
110MP0002116_abnormal_craniofacial_bone0.34903016
111MP0002272_abnormal_nervous_system0.34706509
112MP0003948_abnormal_gas_homeostasis0.34550655
113MP0003699_abnormal_female_reproductive0.34113249
114MP0004197_abnormal_fetal_growth/weight/0.32759575
115MP0000428_abnormal_craniofacial_morphol0.32542450
116MP0002163_abnormal_gland_morphology0.32141625
117MP0004510_myositis0.32003012
118MP0002089_abnormal_postnatal_growth/wei0.31875516
119MP0003111_abnormal_nucleus_morphology0.31510941
120MP0004142_abnormal_muscle_tone0.31442832
121MP0003077_abnormal_cell_cycle0.31432994
122MP0009115_abnormal_fat_cell0.31366632
123MP0005334_abnormal_fat_pad0.30733761
124* MP0002085_abnormal_embryonic_tissue0.30635729
125MP0001697_abnormal_embryo_size0.30011527
126* MP0002109_abnormal_limb_morphology0.28711840
127MP0004043_abnormal_pH_regulation0.28340324
128MP0002177_abnormal_outer_ear0.27473536
129* MP0001730_embryonic_growth_arrest0.26907716
130MP0008770_decreased_survivor_rate0.26854184
131MP0000350_abnormal_cell_proliferation0.25524914
132MP0000432_abnormal_head_morphology0.24600051
133* MP0002066_abnormal_motor_capabilities/c0.23784374

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.83691602
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.51055604
3Nemaline bodies (HP:0003798)8.73234255
4Exercise-induced myalgia (HP:0003738)7.90929350
5Distal arthrogryposis (HP:0005684)7.24490719
6Exercise-induced muscle cramps (HP:0003710)7.13286385
7Type 1 muscle fiber predominance (HP:0003803)6.95060807
8Muscle hypertrophy of the lower extremities (HP:0008968)6.61246623
9Myopathic facies (HP:0002058)6.53018140
10Round ear (HP:0100830)6.28508962
11Ulnar deviation of the wrist (HP:0003049)6.18615458
12Calf muscle hypertrophy (HP:0008981)5.87968951
13Calcaneovalgus deformity (HP:0001848)5.75504652
14Difficulty running (HP:0009046)5.68150929
15Muscle fiber splitting (HP:0003555)5.48791947
16Deformed tarsal bones (HP:0008119)5.25570545
17Absent phalangeal crease (HP:0006109)5.09202314
18Hyporeflexia of lower limbs (HP:0002600)4.37344587
19Muscle stiffness (HP:0003552)4.35118672
20EMG: myopathic abnormalities (HP:0003458)4.32793519
21Myoglobinuria (HP:0002913)4.29062509
22Malignant hyperthermia (HP:0002047)4.26410772
23Abnormal finger flexion creases (HP:0006143)4.25753778
24Increased connective tissue (HP:0009025)4.11519165
25Abnormality of the calf musculature (HP:0001430)4.07595936
26Myotonia (HP:0002486)3.98898612
27Difficulty climbing stairs (HP:0003551)3.93037853
28Rhabdomyolysis (HP:0003201)3.74125352
29Pelvic girdle muscle weakness (HP:0003749)3.65114772
30Shoulder girdle muscle weakness (HP:0003547)3.64125036
31Abnormality of skeletal muscle fiber size (HP:0012084)3.49200136
32Abnormality of the musculature of the pelvis (HP:0001469)3.46872998
33Abnormality of the hip-girdle musculature (HP:0001445)3.46872998
34Abnormality of the calcaneus (HP:0008364)3.42278910
35Neck muscle weakness (HP:0000467)3.39938077
36Fatigable weakness (HP:0003473)3.36062884
37Abnormality of the neuromuscular junction (HP:0003398)3.36062884
38Abnormality of the left ventricular outflow tract (HP:0011103)3.29559937
39Subaortic stenosis (HP:0001682)3.29559937
40Fetal akinesia sequence (HP:0001989)3.25917387
41Increased variability in muscle fiber diameter (HP:0003557)3.09523099
42Areflexia of lower limbs (HP:0002522)3.08929462
43Rimmed vacuoles (HP:0003805)3.08208625
44Frequent falls (HP:0002359)2.83186292
45Gowers sign (HP:0003391)2.57522780
46Weak cry (HP:0001612)2.56105713
47Bundle branch block (HP:0011710)2.56006474
48EMG: neuropathic changes (HP:0003445)2.55997274
49Hyperkalemia (HP:0002153)2.55157582
50Nonprogressive disorder (HP:0003680)2.45819916
51Type 2 muscle fiber atrophy (HP:0003554)2.40716560
52Bulbar palsy (HP:0001283)2.39605772
53Mildly elevated creatine phosphokinase (HP:0008180)2.38850554
54Hypoplastic ischia (HP:0003175)2.38057445
55Proximal amyotrophy (HP:0007126)2.35321042
56Asymmetric septal hypertrophy (HP:0001670)2.33846347
57Limb-girdle muscle weakness (HP:0003325)2.33145427
58Slender build (HP:0001533)2.31502006
59Metatarsus adductus (HP:0001840)2.29110275
60Muscular dystrophy (HP:0003560)2.28480448
61Abnormality of the shoulder girdle musculature (HP:0001435)2.25210462
62Muscle fiber atrophy (HP:0100295)2.23470777
63Sudden death (HP:0001699)2.19213741
64Generalized muscle weakness (HP:0003324)2.19049807
65Ulnar deviation of finger (HP:0009465)2.18838814
66Distal lower limb amyotrophy (HP:0008944)2.18808099
67Dilated cardiomyopathy (HP:0001644)2.18358205
68Hip contracture (HP:0003273)2.17335946
69Distal lower limb muscle weakness (HP:0009053)2.16064407
70Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.07646436
71Acute lymphatic leukemia (HP:0006721)2.07545046
72Scapular winging (HP:0003691)2.06657827
73Paralysis (HP:0003470)2.04287525
74Ventricular tachycardia (HP:0004756)2.02534883
75Abnormality of the ischium (HP:0003174)2.02384822
76Abnormality of the foot musculature (HP:0001436)1.96717091
77Increased density of long bones (HP:0006392)1.95840084
78Facial diplegia (HP:0001349)1.93931522
79Achilles tendon contracture (HP:0001771)1.92734481
80Centrally nucleated skeletal muscle fibers (HP:0003687)1.89431077
81Limb-girdle muscle atrophy (HP:0003797)1.86300571
82Spinal rigidity (HP:0003306)1.86191957
83Exercise intolerance (HP:0003546)1.85041629
84Progressive muscle weakness (HP:0003323)1.84190474
85Waddling gait (HP:0002515)1.83697694
86Lipoatrophy (HP:0100578)1.82618565
87Foot dorsiflexor weakness (HP:0009027)1.82266675
88Short palpebral fissure (HP:0012745)1.81215074
89Tarsal synostosis (HP:0008368)1.78568102
90Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.74629306
91Heart block (HP:0012722)1.72428539
92Abnormality of the Achilles tendon (HP:0005109)1.71429658
93Popliteal pterygium (HP:0009756)1.68054748
94Easy fatigability (HP:0003388)1.66334586
95Fibular aplasia (HP:0002990)1.66025477
96Respiratory insufficiency due to muscle weakness (HP:0002747)1.62991189
97Synostosis involving bones of the lower limbs (HP:0009138)1.62073406
98Synostosis involving bones of the feet (HP:0009140)1.62073406
99Long clavicles (HP:0000890)1.61954597
100Webbed neck (HP:0000465)1.60217473
101Abnormal atrioventricular conduction (HP:0005150)1.59199785
102Lower limb amyotrophy (HP:0007210)1.57945063
103Congenital hip dislocation (HP:0001374)1.56747888
104Breech presentation (HP:0001623)1.56483812
105Abnormality of placental membranes (HP:0011409)1.56149943
106Amniotic constriction ring (HP:0009775)1.56149943
107Steppage gait (HP:0003376)1.55707394
108Wrist flexion contracture (HP:0001239)1.54979639
109Increased intramyocellular lipid droplets (HP:0012240)1.54235799
110Adducted thumb (HP:0001181)1.53835510
111Ragged-red muscle fibers (HP:0003200)1.50135525
112Rocker bottom foot (HP:0001838)1.49782760
113Limited hip movement (HP:0008800)1.49011304
114Ventricular arrhythmia (HP:0004308)1.46198251
115Increased muscle lipid content (HP:0009058)1.44253508
116Hypoplastic heart (HP:0001961)1.40349033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.27225509
2TTN5.18367190
3PHKG24.64555786
4PHKG14.64555786
5NME13.43656110
6LATS13.25335961
7MUSK2.97577223
8PIK3CG2.93569057
9LATS22.76181681
10MOS2.69621606
11TRIB32.39229435
12PINK12.28810130
13NEK12.24158438
14MAP2K32.10169789
15MARK12.09704245
16DMPK1.93088678
17STK38L1.90805389
18MAP3K61.76374205
19MAP2K41.68224330
20MAP3K71.62016504
21TAOK11.61053965
22KSR21.37025790
23CDK81.32931204
24PDK31.23643778
25PDK41.23643778
26MAPK121.21535264
27MAP2K71.08126103
28PRKAA11.04405643
29PIK3CA1.02657475
30DYRK1B1.01711723
31SIK21.01056736
32PAK60.98302350
33ERBB40.96669834
34STK30.95003932
35VRK20.88333770
36CCNB10.86684608
37PRKAA20.84620670
38ICK0.82947194
39STK380.82572583
40MAP2K60.81940210
41MAP3K90.78466242
42STK240.73407870
43EEF2K0.72356344
44MAPKAPK30.70512403
45AKT20.69564642
46MAPK110.68820349
47PDK20.68638535
48MAP3K130.68543149
49BCKDK0.66489381
50RAF10.66138228
51KSR10.64297086
52ILK0.64150700
53PRKD30.63210074
54NEK90.61276883
55MAP3K40.61151177
56CAMK40.60578293
57TAOK30.60409013
58SMG10.59946522
59MAP3K50.59863150
60EPHA40.58203262
61LIMK10.56592755
62PKN10.55234685
63CDC70.54019318
64DYRK20.53918910
65PKN20.53542334
66PLK40.51986600
67MAP2K10.48592198
68TAF10.47685539
69ABL20.45595328
70MAPK40.45459169
71TTK0.45287944
72TYRO30.44518504
73MARK30.44342761
74CAMK10.44275456
75CAMK2G0.44052612
76GRK10.42871570
77TAOK20.41319794
78NEK20.39575122
79CDK90.39223294
80CAMK2A0.37626507
81CHEK20.35720527
82MELK0.35236652
83MAP3K110.34660984
84MAPK70.34490550
85TRPM70.32876270
86ERBB30.32605483
87PRKACA0.31680273
88CAMK2B0.31656288
89MAP3K30.31368250
90EPHB10.31219899
91DYRK30.31106715
92BRAF0.30407384
93MAPK100.30081547
94BMPR20.29885323
95MAPK130.29648655
96CAMK2D0.28491575
97SGK30.28068808
98ADRBK20.27599038
99CDK120.27300472
100RET0.26896337
101RPS6KA30.25905711
102SGK10.24978168
103MTOR0.24596277
104MAP3K80.24491527
105ZAK0.23344401
106MAP3K100.22886218
107HIPK20.22448814
108RPS6KB10.21695128
109ROCK10.20660564
110CSNK1G30.19611900
111RIPK10.19611398
112PRKACB0.19156514
113STK160.19039923
114IRAK30.18973763
115PRKD20.18456072
116MAP3K10.17491358
117SGK20.17002976
118NTRK20.16850986
119CDK50.16365626
120STK110.16363751
121MAPKAPK50.16351771
122CDK150.16134540
123ARAF0.15932631
124RPS6KA10.15781689
125SGK4940.15007918
126SGK2230.15007918
127CDK11A0.14026901
128CSNK1A1L0.13953593
129CASK0.12916291
130PDPK10.12351508
131MARK20.12256607
132CSNK1D0.11836684
133DAPK20.11800576
134CSNK1G20.11733092
135GSK3B0.11627976
136CDK60.11617779
137CSNK1G10.11350726
138CDK180.11245227
139PRKG10.10661069
140CDK140.09669474
141CDK40.09370821
142PRKD10.09310910

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.05508551
2Circadian rhythm_Homo sapiens_hsa047103.76823293
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.56892982
4Dilated cardiomyopathy_Homo sapiens_hsa054143.22537883
5Cardiac muscle contraction_Homo sapiens_hsa042602.83657329
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.81248191
7Insulin signaling pathway_Homo sapiens_hsa049102.45375297
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.34246684
9Oxytocin signaling pathway_Homo sapiens_hsa049212.30333272
10Glucagon signaling pathway_Homo sapiens_hsa049222.19999688
11Starch and sucrose metabolism_Homo sapiens_hsa005002.02397907
12Insulin resistance_Homo sapiens_hsa049311.89266615
13AMPK signaling pathway_Homo sapiens_hsa041521.86906667
14mTOR signaling pathway_Homo sapiens_hsa041501.82233201
15Oxidative phosphorylation_Homo sapiens_hsa001901.81930508
16Tight junction_Homo sapiens_hsa045301.73106320
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70904537
18Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.69207168
19Longevity regulating pathway - mammal_Homo sapiens_hsa042111.57585943
20GnRH signaling pathway_Homo sapiens_hsa049121.57463085
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54449702
22FoxO signaling pathway_Homo sapiens_hsa040681.51677204
23Adipocytokine signaling pathway_Homo sapiens_hsa049201.49655843
24Viral myocarditis_Homo sapiens_hsa054161.43856661
25Sulfur relay system_Homo sapiens_hsa041221.41624322
26Carbon metabolism_Homo sapiens_hsa012001.40822408
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39636776
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.38231132
29Biosynthesis of amino acids_Homo sapiens_hsa012301.32148943
30Renal cell carcinoma_Homo sapiens_hsa052111.26606676
31VEGF signaling pathway_Homo sapiens_hsa043701.25644513
32Calcium signaling pathway_Homo sapiens_hsa040201.24758152
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24287261
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23218327
35Huntingtons disease_Homo sapiens_hsa050161.21056542
36Pentose phosphate pathway_Homo sapiens_hsa000301.18403777
37RNA degradation_Homo sapiens_hsa030181.17858365
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14861941
39MAPK signaling pathway_Homo sapiens_hsa040101.14701289
40Galactose metabolism_Homo sapiens_hsa000521.14001244
41Focal adhesion_Homo sapiens_hsa045101.13677152
42Arginine and proline metabolism_Homo sapiens_hsa003301.11028450
43Oocyte meiosis_Homo sapiens_hsa041141.10440422
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08730368
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.08307175
46Propanoate metabolism_Homo sapiens_hsa006401.06994205
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03367381
48Cell cycle_Homo sapiens_hsa041101.00356333
49Prolactin signaling pathway_Homo sapiens_hsa049170.98583427
50Fructose and mannose metabolism_Homo sapiens_hsa000510.95194493
51Ovarian steroidogenesis_Homo sapiens_hsa049130.95091518
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94822386
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94747145
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94420205
55HIF-1 signaling pathway_Homo sapiens_hsa040660.94079011
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.93814298
57Adherens junction_Homo sapiens_hsa045200.92320148
58Pancreatic cancer_Homo sapiens_hsa052120.92310549
59Dorso-ventral axis formation_Homo sapiens_hsa043200.91830274
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88572085
61Chronic myeloid leukemia_Homo sapiens_hsa052200.86754648
62Phenylalanine metabolism_Homo sapiens_hsa003600.85686707
63Vitamin B6 metabolism_Homo sapiens_hsa007500.83111520
64TGF-beta signaling pathway_Homo sapiens_hsa043500.82906672
65Butanoate metabolism_Homo sapiens_hsa006500.81677911
66Nitrogen metabolism_Homo sapiens_hsa009100.78378586
67Fatty acid degradation_Homo sapiens_hsa000710.78343793
68Long-term depression_Homo sapiens_hsa047300.77648046
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76864561
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76767456
71MicroRNAs in cancer_Homo sapiens_hsa052060.75236237
72Hippo signaling pathway_Homo sapiens_hsa043900.73986383
73Circadian entrainment_Homo sapiens_hsa047130.70205768
74Bladder cancer_Homo sapiens_hsa052190.66415433
75Renin secretion_Homo sapiens_hsa049240.66295352
76Proteoglycans in cancer_Homo sapiens_hsa052050.66118970
77Non-small cell lung cancer_Homo sapiens_hsa052230.65876474
78Gastric acid secretion_Homo sapiens_hsa049710.65844914
79Glioma_Homo sapiens_hsa052140.64591603
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63677401
81Fatty acid metabolism_Homo sapiens_hsa012120.62706964
82Basal transcription factors_Homo sapiens_hsa030220.62495008
83Choline metabolism in cancer_Homo sapiens_hsa052310.61084870
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58497399
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56134607
86ErbB signaling pathway_Homo sapiens_hsa040120.56058050
87Lysine degradation_Homo sapiens_hsa003100.54334554
88Dopaminergic synapse_Homo sapiens_hsa047280.52894525
89Colorectal cancer_Homo sapiens_hsa052100.52332482
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51470521
91Platelet activation_Homo sapiens_hsa046110.51440994
92Alzheimers disease_Homo sapiens_hsa050100.50784079
93Endometrial cancer_Homo sapiens_hsa052130.50386801
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48828965
95Thyroid cancer_Homo sapiens_hsa052160.47510719
96Pyruvate metabolism_Homo sapiens_hsa006200.47295442
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47274536
98Regulation of autophagy_Homo sapiens_hsa041400.45595449
99Notch signaling pathway_Homo sapiens_hsa043300.44889904
100Basal cell carcinoma_Homo sapiens_hsa052170.44853221
101RNA transport_Homo sapiens_hsa030130.44768998
102Insulin secretion_Homo sapiens_hsa049110.44109097
103Wnt signaling pathway_Homo sapiens_hsa043100.43693332
104Parkinsons disease_Homo sapiens_hsa050120.43434817
105Type II diabetes mellitus_Homo sapiens_hsa049300.42523967
106p53 signaling pathway_Homo sapiens_hsa041150.41970869
107Hedgehog signaling pathway_Homo sapiens_hsa043400.40757964
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.40754364
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39279745
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39083159
111Linoleic acid metabolism_Homo sapiens_hsa005910.39059574
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38992483
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38896575
114Amphetamine addiction_Homo sapiens_hsa050310.38275044
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.37856928
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.37030390
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36799223
118Arginine biosynthesis_Homo sapiens_hsa002200.36795044
119Amoebiasis_Homo sapiens_hsa051460.35028258
120Peroxisome_Homo sapiens_hsa041460.34922091
121cAMP signaling pathway_Homo sapiens_hsa040240.33900323
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33897576
123Melanoma_Homo sapiens_hsa052180.32468434
124GABAergic synapse_Homo sapiens_hsa047270.31921312
125Salivary secretion_Homo sapiens_hsa049700.31688277
126Cholinergic synapse_Homo sapiens_hsa047250.30752973
127HTLV-I infection_Homo sapiens_hsa051660.28733923
128Melanogenesis_Homo sapiens_hsa049160.27135704
129Long-term potentiation_Homo sapiens_hsa047200.26985069
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26981027
131mRNA surveillance pathway_Homo sapiens_hsa030150.26811316
132Metabolic pathways_Homo sapiens_hsa011000.26674788
133Olfactory transduction_Homo sapiens_hsa047400.26589638
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26526958
135Purine metabolism_Homo sapiens_hsa002300.26515004
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.26361682
137Phototransduction_Homo sapiens_hsa047440.23141174
138Axon guidance_Homo sapiens_hsa043600.22565768
139Fatty acid elongation_Homo sapiens_hsa000620.21202402

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