LCA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is thought to be involved in centrosomal or ciliary functions. Mutations in this gene cause Leber congenital amaurosis type V. Alternatively spliced transcript variants are described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)6.43692190
2rhodopsin mediated signaling pathway (GO:0016056)6.23652003
3retinal cone cell development (GO:0046549)5.51179885
4photoreceptor cell development (GO:0042461)4.93246089
5eye photoreceptor cell development (GO:0042462)4.81520000
6* photoreceptor cell maintenance (GO:0045494)4.79125501
7axoneme assembly (GO:0035082)4.67884435
8retinal rod cell development (GO:0046548)4.65793147
9atrial cardiac muscle cell action potential (GO:0086014)4.63219817
10cilium movement (GO:0003341)4.59774808
11cilium or flagellum-dependent cell motility (GO:0001539)4.30096239
12eye photoreceptor cell differentiation (GO:0001754)4.19403598
13photoreceptor cell differentiation (GO:0046530)4.19403598
14nonmotile primary cilium assembly (GO:0035058)4.08945054
15centriole replication (GO:0007099)3.77977535
16detection of light stimulus involved in sensory perception (GO:0050962)3.75706857
17detection of light stimulus involved in visual perception (GO:0050908)3.75706857
18epithelial cilium movement (GO:0003351)3.74111077
19* intraciliary transport (GO:0042073)3.68800841
20protein localization to synapse (GO:0035418)3.63561962
21axonemal dynein complex assembly (GO:0070286)3.62306332
22GMP metabolic process (GO:0046037)3.61909183
23axonal fasciculation (GO:0007413)3.61158980
24left/right pattern formation (GO:0060972)3.53985768
25phototransduction (GO:0007602)3.52346407
26ventricular system development (GO:0021591)3.49745447
27phototransduction, visible light (GO:0007603)3.41691855
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.40652145
29visual perception (GO:0007601)3.40566117
30cerebral cortex radially oriented cell migration (GO:0021799)3.39909091
31DNA topological change (GO:0006265)3.39249391
32detection of visible light (GO:0009584)3.38364388
33detection of light stimulus (GO:0009583)3.37516984
34sensory perception of light stimulus (GO:0050953)3.37141033
35retina development in camera-type eye (GO:0060041)3.29647655
36centriole assembly (GO:0098534)3.26856646
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.24372723
38signal peptide processing (GO:0006465)3.22491175
39microtubule severing (GO:0051013)3.22108634
40positive regulation of guanylate cyclase activity (GO:0031284)3.19501594
41neuron recognition (GO:0008038)3.08941126
42microtubule depolymerization (GO:0007019)3.08314209
43microtubule bundle formation (GO:0001578)3.04618741
44cilium organization (GO:0044782)3.04590740
45response to pheromone (GO:0019236)3.00360537
46cilium assembly (GO:0042384)2.96955549
47neuron cell-cell adhesion (GO:0007158)2.96539000
48negative regulation of activin receptor signaling pathway (GO:0032926)2.90061842
49retinal ganglion cell axon guidance (GO:0031290)2.89937687
50negative regulation of axon extension involved in axon guidance (GO:0048843)2.86027620
51protein-chromophore linkage (GO:0018298)2.85842357
52motile cilium assembly (GO:0044458)2.85460896
53appendage development (GO:0048736)2.83105374
54limb development (GO:0060173)2.83105374
55cellular response to light stimulus (GO:0071482)2.79871726
56apical protein localization (GO:0045176)2.77962568
57presynaptic membrane assembly (GO:0097105)2.75797463
58central nervous system projection neuron axonogenesis (GO:0021952)2.75332632
59negative regulation of protein localization to cell surface (GO:2000009)2.74164435
60determination of left/right symmetry (GO:0007368)2.74155374
61ganglion development (GO:0061548)2.73998107
62presynaptic membrane organization (GO:0097090)2.73285104
63positive regulation of growth hormone secretion (GO:0060124)2.70746720
64regulation of guanylate cyclase activity (GO:0031282)2.68777833
65cilium morphogenesis (GO:0060271)2.68042418
66olfactory bulb development (GO:0021772)2.67574705
67determination of bilateral symmetry (GO:0009855)2.67053291
68retina layer formation (GO:0010842)2.66721960
69microtubule polymerization or depolymerization (GO:0031109)2.66602154
70positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.66436873
71positive regulation of CREB transcription factor activity (GO:0032793)2.63492113
72specification of symmetry (GO:0009799)2.63223527
73negative regulation of axon guidance (GO:1902668)2.62162570
74axon extension involved in axon guidance (GO:0048846)2.61228569
75neuron projection extension involved in neuron projection guidance (GO:1902284)2.61228569
76limb bud formation (GO:0060174)2.61024612
77regulation of microtubule-based movement (GO:0060632)2.60602970
78cell projection assembly (GO:0030031)2.60554877
79protein localization to cilium (GO:0061512)2.55836819
80regulation of development, heterochronic (GO:0040034)2.53380657
81transmission of nerve impulse (GO:0019226)2.51793165
82establishment of nucleus localization (GO:0040023)2.51466519
83lipid particle organization (GO:0034389)2.50996410
84neuronal action potential propagation (GO:0019227)2.50374627
85regulation of short-term neuronal synaptic plasticity (GO:0048172)2.50272559
86kidney morphogenesis (GO:0060993)2.48695545
87cellular component assembly involved in morphogenesis (GO:0010927)2.48673722
88regulation of growth hormone secretion (GO:0060123)2.48658059
89positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.47914388
90layer formation in cerebral cortex (GO:0021819)2.46419355
91stress granule assembly (GO:0034063)2.45478045
92detection of external stimulus (GO:0009581)2.43941941
93protein polyglutamylation (GO:0018095)2.43614582
94detection of abiotic stimulus (GO:0009582)2.43236327
95histone H2A acetylation (GO:0043968)2.38492212
96regulation of timing of cell differentiation (GO:0048505)2.36031703
97smoothened signaling pathway (GO:0007224)2.35671107
98central nervous system neuron axonogenesis (GO:0021955)2.34797097
99dendritic spine morphogenesis (GO:0060997)2.34493423
100cell differentiation involved in metanephros development (GO:0072202)2.33808473
101asymmetric protein localization (GO:0008105)2.33622679
102neurotransmitter-gated ion channel clustering (GO:0072578)2.33434916
103cell-cell junction maintenance (GO:0045217)2.33389356
104cranial nerve structural organization (GO:0021604)2.33373959
105startle response (GO:0001964)2.31388728
106prenylation (GO:0097354)2.30885360
107protein prenylation (GO:0018342)2.30885360
108nucleus localization (GO:0051647)2.30742145
109negative regulation of transcription regulatory region DNA binding (GO:2000678)2.29569624
110motor neuron axon guidance (GO:0008045)2.29395707
111cell differentiation involved in kidney development (GO:0061005)2.27472762
112negative regulation of hormone biosynthetic process (GO:0032353)2.26751333
113negative regulation of hormone metabolic process (GO:0032351)2.26751333
114pyrimidine nucleobase catabolic process (GO:0006208)2.26447012
115vocalization behavior (GO:0071625)2.26445641
116acrosome assembly (GO:0001675)2.25424872
117positive regulation of gastrulation (GO:2000543)2.24987141
118platelet dense granule organization (GO:0060155)2.24969245
119mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.24819460
120positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.24819460
121regulation of cilium movement (GO:0003352)2.24795727
122establishment of tissue polarity (GO:0007164)2.24504426
123establishment of planar polarity (GO:0001736)2.24504426
124regulation of meiosis I (GO:0060631)2.24434042
125* microtubule-based movement (GO:0007018)2.23562187
126neural tube formation (GO:0001841)2.23325440
127cerebellum development (GO:0021549)2.23194387
128left/right axis specification (GO:0070986)2.22886710
129lateral sprouting from an epithelium (GO:0060601)2.22760556
130nerve growth factor signaling pathway (GO:0038180)2.22478524
131regulation of transforming growth factor beta2 production (GO:0032909)2.21931107
132anatomical structure arrangement (GO:0048532)2.21235538
133regulation of cGMP metabolic process (GO:0030823)2.21114407
134positive regulation of action potential (GO:0045760)2.20926219
135neural crest cell development (GO:0014032)2.19915827
136regulation of respiratory system process (GO:0044065)2.19729618
137negative regulation of keratinocyte proliferation (GO:0010839)2.19444158
138vascular smooth muscle contraction (GO:0014829)2.18769485
139G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.18368907
140regulation of axon guidance (GO:1902667)2.17886318
141synapsis (GO:0007129)2.16358505
142protein localization to microtubule cytoskeleton (GO:0072698)2.16320088
143mechanosensory behavior (GO:0007638)2.15448884
144calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.15351196
145regulation of chemokine-mediated signaling pathway (GO:0070099)2.12426290
146embryonic retina morphogenesis in camera-type eye (GO:0060059)2.11871553
147cornea development in camera-type eye (GO:0061303)2.11868584
148synapse assembly (GO:0007416)2.11579378
149* microtubule-based transport (GO:0010970)2.11334518
150organelle assembly (GO:0070925)2.10906147
151homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.10573394
152regulation of non-canonical Wnt signaling pathway (GO:2000050)2.10269518
153cranial nerve development (GO:0021545)2.09595957
154glycosphingolipid biosynthetic process (GO:0006688)2.09564310
155neuron fate determination (GO:0048664)2.08874793
156short-term memory (GO:0007614)2.08812772
157positive regulation of dendritic spine morphogenesis (GO:0061003)2.07286842
158* microtubule-based process (GO:0007017)2.06765226
159regulation of microtubule depolymerization (GO:0031114)2.06246578

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.89008340
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.39689377
3GBX2_23144817_ChIP-Seq_PC3_Human3.34803433
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.08819383
5ZNF274_21170338_ChIP-Seq_K562_Hela2.42416362
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.10727586
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.07573294
8CBX2_27304074_Chip-Seq_ESCs_Mouse2.07479951
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01010970
10JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99838527
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98128768
12SMAD_19615063_ChIP-ChIP_OVARY_Human1.96054337
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90583310
14ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85373576
15EED_16625203_ChIP-ChIP_MESCs_Mouse1.81533588
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77670225
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77670225
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77570308
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76611289
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74932312
21P300_19829295_ChIP-Seq_ESCs_Human1.73682578
22VDR_22108803_ChIP-Seq_LS180_Human1.73526305
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72683819
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69534123
25* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68515491
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68243372
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.67980575
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66820333
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66690765
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65132240
31SMAD4_21799915_ChIP-Seq_A2780_Human1.65119238
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63554945
33RNF2_27304074_Chip-Seq_NSC_Mouse1.63305544
34DROSHA_22980978_ChIP-Seq_HELA_Human1.61897913
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60050136
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59884909
37FUS_26573619_Chip-Seq_HEK293_Human1.59552728
38AR_21572438_ChIP-Seq_LNCaP_Human1.59410751
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58713398
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.57726647
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53772329
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51865084
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51865084
44REST_21632747_ChIP-Seq_MESCs_Mouse1.49244549
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46194702
46* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45783990
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.45731825
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45133202
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.44327599
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43958881
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.43762020
52ER_23166858_ChIP-Seq_MCF-7_Human1.43301940
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.42284115
54TP53_18474530_ChIP-ChIP_U2OS_Human1.42117374
55* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40152900
56TAF15_26573619_Chip-Seq_HEK293_Human1.39869651
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38166057
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37088240
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36559035
60TP53_16413492_ChIP-PET_HCT116_Human1.36032070
61* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35450623
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34533077
63* STAT3_23295773_ChIP-Seq_U87_Human1.34009117
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32826847
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31840878
66TCF4_23295773_ChIP-Seq_U87_Human1.31226837
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.31157917
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.29698195
69AHR_22903824_ChIP-Seq_MCF-7_Human1.27299818
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26440368
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.26399238
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26119089
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25732162
74SOX9_26525672_Chip-Seq_HEART_Mouse1.25034211
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24864050
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24275921
77STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23965824
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23845723
79RUNX2_22187159_ChIP-Seq_PCA_Human1.23501358
80EWS_26573619_Chip-Seq_HEK293_Human1.22749497
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.20673640
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20505999
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20505999
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20347952
85CBP_20019798_ChIP-Seq_JUKART_Human1.20347952
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20097198
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19820916
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19363519
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19197751
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18256783
91IGF1R_20145208_ChIP-Seq_DFB_Human1.17449427
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.17316279
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16729245
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16670989
95RING1B_27294783_Chip-Seq_ESCs_Mouse1.16367534
96SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.15929997
97* TCF4_22108803_ChIP-Seq_LS180_Human1.14314372
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13956325
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13400522
100AR_19668381_ChIP-Seq_PC3_Human1.12507080
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12377704
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.11978150
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11364005
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.11082789
105SMAD4_21741376_ChIP-Seq_EPCs_Human1.10808610
106TAL1_26923725_Chip-Seq_HPCs_Mouse1.10782859
107WDR5_24793694_ChIP-Seq_LNCAP_Human1.09810500
108AR_25329375_ChIP-Seq_VCAP_Human1.09505433
109JUN_21703547_ChIP-Seq_K562_Human1.09480250
110EZH2_27294783_Chip-Seq_NPCs_Mouse1.08994233
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08374424
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07676837
113EP300_21415370_ChIP-Seq_HL-1_Mouse1.06706313
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06464630
115P53_22387025_ChIP-Seq_ESCs_Mouse1.06441132
116CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06105828
117GF1B_26923725_Chip-Seq_HPCs_Mouse1.05844349
118P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05395285
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05342918
120YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04905957
121SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04586471
122TBL1_22424771_ChIP-Seq_293T_Human1.03880724
123SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03624145
124WT1_19549856_ChIP-ChIP_CCG9911_Human1.03537982
125TP63_19390658_ChIP-ChIP_HaCaT_Human1.03227051
126PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02847304
127BCAT_22108803_ChIP-Seq_LS180_Human1.01845443
128TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00341060
129CDX2_22108803_ChIP-Seq_LS180_Human1.00229621
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00114561
131TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99766072
132P300_18555785_Chip-Seq_ESCs_Mouse0.99726452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog4.54067152
2MP0005253_abnormal_eye_physiology3.36541566
3MP0006072_abnormal_retinal_apoptosis3.27991610
4MP0006292_abnormal_olfactory_placode3.17445653
5MP0003011_delayed_dark_adaptation2.77917126
6MP0004270_analgesia2.20252954
7MP0005195_abnormal_posterior_eye2.10430758
8MP0003950_abnormal_plasma_membrane2.08198534
9MP0003880_abnormal_central_pattern2.06571419
10MP0000778_abnormal_nervous_system2.02399105
11MP0009780_abnormal_chondrocyte_physiolo2.00551768
12MP0004859_abnormal_synaptic_plasticity1.99714383
13MP0001984_abnormal_olfaction1.99399997
14MP0005423_abnormal_somatic_nervous1.93823827
15MP0008057_abnormal_DNA_replication1.93475157
16MP0005391_vision/eye_phenotype1.92357463
17MP0005645_abnormal_hypothalamus_physiol1.89032078
18MP0005394_taste/olfaction_phenotype1.85014811
19MP0005499_abnormal_olfactory_system1.85014811
20MP0005248_abnormal_Harderian_gland1.83901024
21MP0003136_yellow_coat_color1.83208020
22MP0008789_abnormal_olfactory_epithelium1.82037115
23MP0008877_abnormal_DNA_methylation1.79992477
24MP0003890_abnormal_embryonic-extraembry1.76134551
25MP0001324_abnormal_eye_pigmentation1.76083094
26MP0002638_abnormal_pupillary_reflex1.71085580
27MP0002653_abnormal_ependyma_morphology1.70415268
28MP0010030_abnormal_orbit_morphology1.66369843
29MP0002734_abnormal_mechanical_nocicepti1.65867696
30MP0002938_white_spotting1.62916477
31MP0003122_maternal_imprinting1.61958444
32MP0005623_abnormal_meninges_morphology1.61270633
33MP0002752_abnormal_somatic_nervous1.61242951
34MP0002184_abnormal_innervation1.60145153
35MP0003635_abnormal_synaptic_transmissio1.58855317
36MP0002882_abnormal_neuron_morphology1.58645517
37MP0003121_genomic_imprinting1.58366677
38MP0004233_abnormal_muscle_weight1.57787099
39MP0003787_abnormal_imprinting1.54139053
40MP0000631_abnormal_neuroendocrine_gland1.50115750
41MP0001486_abnormal_startle_reflex1.49774567
42MP0003283_abnormal_digestive_organ1.46521237
43MP0002102_abnormal_ear_morphology1.46291575
44MP0005187_abnormal_penis_morphology1.42629527
45MP0002063_abnormal_learning/memory/cond1.36015911
46MP0002160_abnormal_reproductive_system1.35428316
47MP0002557_abnormal_social/conspecific_i1.35394965
48MP0002234_abnormal_pharynx_morphology1.34530967
49MP0001968_abnormal_touch/_nociception1.34133935
50MP0001879_abnormal_lymphatic_vessel1.33115670
51MP0002229_neurodegeneration1.29057786
52MP0003937_abnormal_limbs/digits/tail_de1.29029415
53MP0003861_abnormal_nervous_system1.28009925
54MP0003123_paternal_imprinting1.26621544
55MP0003119_abnormal_digestive_system1.25629287
56MP0002572_abnormal_emotion/affect_behav1.25612765
57MP0001485_abnormal_pinna_reflex1.24417830
58MP0002736_abnormal_nociception_after1.24052270
59MP0002822_catalepsy1.23485418
60MP0005367_renal/urinary_system_phenotyp1.21771630
61MP0000516_abnormal_urinary_system1.21771630
62MP0000049_abnormal_middle_ear1.21168470
63MP0002064_seizures1.20055971
64MP0001346_abnormal_lacrimal_gland1.20027853
65MP0002272_abnormal_nervous_system1.18798447
66MP0002067_abnormal_sensory_capabilities1.18459382
67MP0001188_hyperpigmentation1.17943556
68MP0006276_abnormal_autonomic_nervous1.17942754
69MP0001502_abnormal_circadian_rhythm1.17259237
70MP0004133_heterotaxia1.16778433
71MP0010368_abnormal_lymphatic_system1.16476770
72MP0002751_abnormal_autonomic_nervous1.13906812
73MP0002282_abnormal_trachea_morphology1.11765294
74MP0002152_abnormal_brain_morphology1.09551891
75MP0003942_abnormal_urinary_system1.09391908
76MP0000383_abnormal_hair_follicle1.08734706
77MP0009046_muscle_twitch1.08134622
78MP0001293_anophthalmia1.08060087
79MP0002090_abnormal_vision1.07608156
80MP0002735_abnormal_chemical_nociception1.06260282
81MP0003878_abnormal_ear_physiology1.06176068
82MP0005377_hearing/vestibular/ear_phenot1.06176068
83MP0009745_abnormal_behavioral_response1.05422685
84MP0004885_abnormal_endolymph1.04720104
85MP0001177_atelectasis1.04235765
86MP0003137_abnormal_impulse_conducting1.03150518
87MP0000566_synostosis1.02782700
88MP0005379_endocrine/exocrine_gland_phen0.99044407
89MP0001929_abnormal_gametogenesis0.98696649
90MP0009250_abnormal_appendicular_skeleto0.98549771
91MP0001286_abnormal_eye_development0.97599115
92MP0002127_abnormal_cardiovascular_syste0.96690918
93MP0000955_abnormal_spinal_cord0.96511761
94MP0004858_abnormal_nervous_system0.95610302
95MP0003634_abnormal_glial_cell0.95481297
96MP0003938_abnormal_ear_development0.93681305
97MP0009053_abnormal_anal_canal0.93245359
98MP0004811_abnormal_neuron_physiology0.92855199
99MP0002233_abnormal_nose_morphology0.92401816
100MP0008569_lethality_at_weaning0.91542484
101MP0002249_abnormal_larynx_morphology0.91507322
102MP0003385_abnormal_body_wall0.91302990
103MP0001529_abnormal_vocalization0.90500787
104MP0008875_abnormal_xenobiotic_pharmacok0.88621612
105MP0004147_increased_porphyrin_level0.88406205
106MP0002909_abnormal_adrenal_gland0.88342119
107MP0002876_abnormal_thyroid_physiology0.88251807
108MP0003935_abnormal_craniofacial_develop0.87577170
109MP0002116_abnormal_craniofacial_bone0.87093555
110MP0000427_abnormal_hair_cycle0.86333178
111MP0003755_abnormal_palate_morphology0.86234184
112MP0003941_abnormal_skin_development0.86227580
113MP0000428_abnormal_craniofacial_morphol0.85511354
114MP0002210_abnormal_sex_determination0.85407524
115MP0004134_abnormal_chest_morphology0.84986126
116MP0000537_abnormal_urethra_morphology0.83844780
117MP0002697_abnormal_eye_size0.82841588
118MP0004215_abnormal_myocardial_fiber0.82827599
119MP0001299_abnormal_eye_distance/0.82532409
120MP0004043_abnormal_pH_regulation0.82440301
121MP0003718_maternal_effect0.81194834
122MP0000026_abnormal_inner_ear0.80439160
123MP0001963_abnormal_hearing_physiology0.80063845
124MP0010386_abnormal_urinary_bladder0.78199092
125MP0005646_abnormal_pituitary_gland0.78011082
126MP0003698_abnormal_male_reproductive0.77081050
127MP0000534_abnormal_ureter_morphology0.76985107
128MP0005389_reproductive_system_phenotype0.73827410
129MP0005410_abnormal_fertilization0.73126348
130MP0004085_abnormal_heartbeat0.70236094
131MP0003115_abnormal_respiratory_system0.69301674
132MP0004924_abnormal_behavior0.69203751

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.33435343
2Bony spicule pigmentary retinopathy (HP:0007737)5.43593671
3Chorioretinal atrophy (HP:0000533)4.63232769
4Abnormal rod and cone electroretinograms (HP:0008323)4.47514645
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.44812573
6Abnormal ciliary motility (HP:0012262)4.44322225
7Abnormal respiratory motile cilium physiology (HP:0012261)4.33976849
8Dyschromatopsia (HP:0007641)4.30198169
9Absent rod-and cone-mediated responses on ERG (HP:0007688)4.11312697
10Central scotoma (HP:0000603)4.07867877
11Pendular nystagmus (HP:0012043)4.04948330
12Gait imbalance (HP:0002141)3.81244473
13Scotoma (HP:0000575)3.76876609
14Congenital primary aphakia (HP:0007707)3.62398633
15Abnormality of macular pigmentation (HP:0008002)3.54529532
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.53052284
17Absent/shortened dynein arms (HP:0200106)3.53052284
18Degeneration of anterior horn cells (HP:0002398)3.44838355
19Abnormality of the anterior horn cell (HP:0006802)3.44838355
20Abnormality of the lower motor neuron (HP:0002366)3.43605292
21Medial flaring of the eyebrow (HP:0010747)3.42630650
22Nephrogenic diabetes insipidus (HP:0009806)3.41084842
23Abnormal respiratory epithelium morphology (HP:0012253)3.31539058
24Abnormal respiratory motile cilium morphology (HP:0005938)3.31539058
25Severe visual impairment (HP:0001141)3.23446210
26Attenuation of retinal blood vessels (HP:0007843)3.22207578
27Vitreoretinal degeneration (HP:0000655)3.17364591
28Rhinitis (HP:0012384)3.15866001
29Pigmentary retinal degeneration (HP:0001146)3.14036956
30Decreased central vision (HP:0007663)3.04335737
31Genital tract atresia (HP:0001827)3.00648371
32Nephronophthisis (HP:0000090)2.97598382
33Vaginal atresia (HP:0000148)2.95728744
34Amyotrophic lateral sclerosis (HP:0007354)2.95465797
35True hermaphroditism (HP:0010459)2.89794578
36Type II diabetes mellitus (HP:0005978)2.86210852
37Poor coordination (HP:0002370)2.85880975
38Pancreatic fibrosis (HP:0100732)2.84740845
39* Abolished electroretinogram (ERG) (HP:0000550)2.80788705
40Choroideremia (HP:0001139)2.73709277
41Molar tooth sign on MRI (HP:0002419)2.65731363
42Abnormality of midbrain morphology (HP:0002418)2.65731363
43Photophobia (HP:0000613)2.63454147
44Retinitis pigmentosa (HP:0000510)2.59598763
45Keratoconus (HP:0000563)2.56055879
46Increased corneal curvature (HP:0100692)2.56055879
47Aplasia/Hypoplasia of the lens (HP:0008063)2.55461695
48Occipital encephalocele (HP:0002085)2.40825367
49Chronic hepatic failure (HP:0100626)2.36416616
50Cone-rod dystrophy (HP:0000548)2.34454678
51Abnormality of the renal medulla (HP:0100957)2.34337284
52Male pseudohermaphroditism (HP:0000037)2.31206290
53Constricted visual fields (HP:0001133)2.28090160
54Abnormality of the labia minora (HP:0012880)2.24235092
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.20676522
56Pancreatic cysts (HP:0001737)2.20628222
57Infertility (HP:0000789)2.18940851
58Gaze-evoked nystagmus (HP:0000640)2.17901348
59Oculomotor apraxia (HP:0000657)2.15963212
60Postaxial foot polydactyly (HP:0001830)2.15319110
61Postaxial hand polydactyly (HP:0001162)2.14131424
62Bell-shaped thorax (HP:0001591)2.12003664
63Septo-optic dysplasia (HP:0100842)2.04294692
64Bifid tongue (HP:0010297)2.03784366
65Anencephaly (HP:0002323)1.94436473
66Tubulointerstitial abnormality (HP:0001969)1.93886680
67Atrophy/Degeneration involving motor neurons (HP:0007373)1.93230268
68Nasal polyposis (HP:0100582)1.92149260
69Conjunctival telangiectasia (HP:0000524)1.91927975
70Preaxial hand polydactyly (HP:0001177)1.91429925
71Intestinal atresia (HP:0011100)1.87709856
72Cystic liver disease (HP:0006706)1.86054418
73Tubulointerstitial nephritis (HP:0001970)1.85387756
74Broad foot (HP:0001769)1.84816732
75Furrowed tongue (HP:0000221)1.83265303
76Hepatoblastoma (HP:0002884)1.81221579
77Atonic seizures (HP:0010819)1.80840252
78Chronic bronchitis (HP:0004469)1.80271658
79Optic nerve hypoplasia (HP:0000609)1.79730657
80Sclerocornea (HP:0000647)1.77116711
81Astigmatism (HP:0000483)1.75358189
82Posterior subcapsular cataract (HP:0007787)1.75351018
83Aplasia/Hypoplasia of the sternum (HP:0006714)1.74623725
84Cerebellar dysplasia (HP:0007033)1.72749749
85Hyperventilation (HP:0002883)1.72579506
86Tubular atrophy (HP:0000092)1.71736035
87Drooling (HP:0002307)1.71385794
88Hyperglycinemia (HP:0002154)1.71252933
89Median cleft lip (HP:0000161)1.71088988
90Genetic anticipation (HP:0003743)1.70542101
91Macular degeneration (HP:0000608)1.70306867
92Micropenis (HP:0000054)1.69474870
93Supernumerary spleens (HP:0009799)1.69361158
94Specific learning disability (HP:0001328)1.68078945
95Renal dysplasia (HP:0000110)1.65778825
96Embryonal renal neoplasm (HP:0011794)1.65052817
97Short foot (HP:0001773)1.64498520
98Absent speech (HP:0001344)1.64303788
99Abnormality of the ischium (HP:0003174)1.64169266
100Abnormality of the renal cortex (HP:0011035)1.62692742
101Anophthalmia (HP:0000528)1.61323439
102Abnormality of abdominal situs (HP:0011620)1.61293798
103Abdominal situs inversus (HP:0003363)1.61293798
104Abnormal hair whorl (HP:0010721)1.61085374
105Upper motor neuron abnormality (HP:0002127)1.60616381
106Congenital hepatic fibrosis (HP:0002612)1.59483446
107Nephroblastoma (Wilms tumor) (HP:0002667)1.59469138
108Progressive cerebellar ataxia (HP:0002073)1.59284236
109Male infertility (HP:0003251)1.58509421
110Multicystic kidney dysplasia (HP:0000003)1.58419687
111Lissencephaly (HP:0001339)1.57976598
112Epileptic encephalopathy (HP:0200134)1.57851136
113Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.57298810
114Bronchiectasis (HP:0002110)1.56959207
115Facial hemangioma (HP:0000329)1.56433197
116Narrow forehead (HP:0000341)1.55104277
117Hypoplastic ischia (HP:0003175)1.55059767
118Renal duplication (HP:0000075)1.53911146
119Labial hypoplasia (HP:0000066)1.53719626
120Abnormality of dentin (HP:0010299)1.52900333
121Protruding tongue (HP:0010808)1.51519493
122Volvulus (HP:0002580)1.51370801
123Tubulointerstitial fibrosis (HP:0005576)1.50458110
124Dental crowding (HP:0000678)1.48589296
125Gastrointestinal atresia (HP:0002589)1.48254042
126Chorioretinal coloboma (HP:0000567)1.48218393
127Absent eyebrow (HP:0002223)1.48174780
128Prominent nasal bridge (HP:0000426)1.47406476
129Hypoplastic labia majora (HP:0000059)1.47183774
130Renal hypoplasia (HP:0000089)1.47000495
131Aganglionic megacolon (HP:0002251)1.46989575
132Scrotal hypoplasia (HP:0000046)1.46712739
133Cutaneous finger syndactyly (HP:0010554)1.45434402
134Decreased testicular size (HP:0008734)1.44759994
135Facial cleft (HP:0002006)1.44546093
136Chronic sinusitis (HP:0011109)1.44434195
137Excessive salivation (HP:0003781)1.44126720
138Febrile seizures (HP:0002373)1.42898008
139Aplasia/Hypoplasia of the tibia (HP:0005772)1.42504711
140Congenital sensorineural hearing impairment (HP:0008527)1.41968239
141Wide nasal bridge (HP:0000431)1.41959887
142Papillary thyroid carcinoma (HP:0002895)1.40168075
143Abnormality of the vasculature of the conjunctiva (HP:0008054)1.39839614
144Exotropia (HP:0000577)1.39564143
145Hemiparesis (HP:0001269)1.39460062

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK12.96702794
2EPHA42.80289472
3GRK12.79377204
4UHMK12.59205664
5MAPK132.47928014
6AKT32.25698456
7MST42.24008397
8NUAK12.22998522
9CASK2.20865506
10BCR2.10895095
11PRPF4B2.06700689
12NTRK32.01255792
13TRIM281.97717232
14MAPK151.96369788
15EPHB21.91591277
16STK38L1.85380311
17SGK21.83178539
18NTRK21.82386646
19MAP3K41.81217067
20SGK4941.78633828
21SGK2231.78633828
22BRD41.78415030
23SIK31.74024665
24MAP4K21.69349091
25PBK1.64836797
26PRKD31.63613124
27BRSK21.59369091
28IRAK21.59267205
29MAP2K71.58347768
30WNK31.52369494
31CSNK1A1L1.50248571
32BMPR1B1.48550824
33PNCK1.48209036
34WEE11.45069787
35KSR11.39160478
36NEK61.36273804
37FRK1.35878641
38CAMKK11.35000252
39ERBB31.30638362
40BUB11.28962920
41PLK21.28694889
42FGFR21.25393173
43DYRK21.25388554
44WNK11.22100484
45DYRK31.19014744
46DYRK1A1.18916833
47MKNK21.12875123
48LATS11.10713079
49STK31.09319257
50PTK2B1.08901667
51STK391.08480499
52PLK31.07728007
53WNK41.04019401
54YES11.03489650
55PAK31.01969200
56SGK31.00683507
57SIK20.98666869
58PASK0.96070541
59PAK60.95165847
60MINK10.93834838
61CSNK1D0.93373662
62CSNK1G10.93368200
63IRAK10.91755249
64MET0.91617199
65CAMK1G0.88638100
66PHKG10.87395060
67PHKG20.87395060
68PINK10.84295370
69CDK60.78635320
70PRKCE0.78137052
71PRKCG0.75988226
72CDK50.75472914
73TNIK0.74525707
74OXSR10.72460604
75MKNK10.72040902
76CDK120.71876436
77ROCK10.71732292
78CDC42BPA0.71641182
79DMPK0.71638124
80PRKD20.71603480
81CDC70.71079435
82PLK10.70802505
83NME10.70537156
84NEK10.69350783
85FER0.69154235
86CSNK1G20.68652096
87STK240.67847137
88HIPK20.66568153
89NTRK10.66203904
90CAMK2A0.65901840
91CAMK2B0.65377831
92MAPK100.64847283
93NEK90.64194990
94ADRBK10.63959687
95VRK10.62743623
96DAPK20.61938833
97DYRK1B0.61808335
98PKN10.61709845
99CSNK1G30.61641403
100TAOK20.61267909
101BRAF0.61244398
102FGFR10.61241226
103ZAK0.59506576
104PRKCH0.57399032
105PLK40.56813416
106CHEK10.55212203
107STK160.55153922
108GSK3B0.54871167
109ACVR1B0.54379267
110CDK10.54203960
111FGR0.53806031
112PRKCZ0.53449784
113SGK10.52773576
114TGFBR10.50908878
115TTK0.50650406
116BMPR20.49325095
117MAP3K120.48699906
118PRKDC0.47943311
119ATM0.47406140
120MAP2K40.47276049
121CAMK2D0.47155011
122EPHA30.46713652
123CDK30.46182185
124ICK0.45738709
125DDR20.45277193
126PRKG10.45009380
127RPS6KA30.44606126
128MAP3K20.44483368
129PRKCB0.43973829
130INSRR0.43770106
131EIF2AK30.43298440
132ADRBK20.43296030
133CSNK1E0.42703275
134EPHA20.42397871
135ERBB20.38995935
136PRKCI0.38628333
137CCNB10.33740190
138ILK0.33483486
139PRKACA0.32170659
140BRSK10.32009529

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047448.39455996
2Protein export_Homo sapiens_hsa030603.80631029
3Olfactory transduction_Homo sapiens_hsa047402.35917035
4Glutamatergic synapse_Homo sapiens_hsa047242.05685400
5Nicotine addiction_Homo sapiens_hsa050332.00950092
6Fanconi anemia pathway_Homo sapiens_hsa034601.85909261
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.83068616
8Axon guidance_Homo sapiens_hsa043601.82757141
9GABAergic synapse_Homo sapiens_hsa047271.80272208
10Morphine addiction_Homo sapiens_hsa050321.79298622
11Circadian entrainment_Homo sapiens_hsa047131.78834373
12Serotonergic synapse_Homo sapiens_hsa047261.68202977
13Dopaminergic synapse_Homo sapiens_hsa047281.68161680
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64440855
15Taste transduction_Homo sapiens_hsa047421.58704656
16Propanoate metabolism_Homo sapiens_hsa006401.57054566
17Hedgehog signaling pathway_Homo sapiens_hsa043401.56035877
18Huntingtons disease_Homo sapiens_hsa050161.50563483
19Insulin secretion_Homo sapiens_hsa049111.49396736
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.46194199
21Synaptic vesicle cycle_Homo sapiens_hsa047211.42460427
22Cholinergic synapse_Homo sapiens_hsa047251.42362952
23Homologous recombination_Homo sapiens_hsa034401.38738677
24Basal cell carcinoma_Homo sapiens_hsa052171.37901685
25Long-term potentiation_Homo sapiens_hsa047201.37817302
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37441839
27Amphetamine addiction_Homo sapiens_hsa050311.35491965
28Wnt signaling pathway_Homo sapiens_hsa043101.34014295
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32793819
30beta-Alanine metabolism_Homo sapiens_hsa004101.31672089
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30522847
32TGF-beta signaling pathway_Homo sapiens_hsa043501.28826213
33Butanoate metabolism_Homo sapiens_hsa006501.28477714
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23062156
35Chemical carcinogenesis_Homo sapiens_hsa052041.18463215
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15701834
37Cocaine addiction_Homo sapiens_hsa050301.15144334
38Hippo signaling pathway_Homo sapiens_hsa043901.14008484
39Vitamin B6 metabolism_Homo sapiens_hsa007501.13060574
40Oxytocin signaling pathway_Homo sapiens_hsa049211.09672276
41Nitrogen metabolism_Homo sapiens_hsa009101.06926842
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03890866
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03738078
44Histidine metabolism_Homo sapiens_hsa003401.03060775
45mRNA surveillance pathway_Homo sapiens_hsa030151.02237310
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02024539
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01075353
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00678155
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99583916
50Melanogenesis_Homo sapiens_hsa049160.98803462
51Calcium signaling pathway_Homo sapiens_hsa040200.97688905
52ErbB signaling pathway_Homo sapiens_hsa040120.96581138
53Circadian rhythm_Homo sapiens_hsa047100.96164799
54Oocyte meiosis_Homo sapiens_hsa041140.95354586
55Tight junction_Homo sapiens_hsa045300.95034347
56Renin secretion_Homo sapiens_hsa049240.94625706
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94583469
58Peroxisome_Homo sapiens_hsa041460.93232285
59cAMP signaling pathway_Homo sapiens_hsa040240.92118717
60Tyrosine metabolism_Homo sapiens_hsa003500.90609790
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90078657
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90014755
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89868281
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89769444
65Oxidative phosphorylation_Homo sapiens_hsa001900.89731625
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89182831
67Long-term depression_Homo sapiens_hsa047300.86029727
68Retinol metabolism_Homo sapiens_hsa008300.83370608
69Alcoholism_Homo sapiens_hsa050340.82657421
70Gastric acid secretion_Homo sapiens_hsa049710.82651925
71GnRH signaling pathway_Homo sapiens_hsa049120.81428356
72Selenocompound metabolism_Homo sapiens_hsa004500.80757580
73Salivary secretion_Homo sapiens_hsa049700.80719057
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79275413
75Colorectal cancer_Homo sapiens_hsa052100.79006996
76Dorso-ventral axis formation_Homo sapiens_hsa043200.77334865
77Dilated cardiomyopathy_Homo sapiens_hsa054140.76845738
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.76054188
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74905282
80ABC transporters_Homo sapiens_hsa020100.73634084
81Parkinsons disease_Homo sapiens_hsa050120.73198073
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72887550
83Mismatch repair_Homo sapiens_hsa034300.70422900
84Cell cycle_Homo sapiens_hsa041100.70354416
85Glutathione metabolism_Homo sapiens_hsa004800.70079921
86Gap junction_Homo sapiens_hsa045400.69230213
87RNA degradation_Homo sapiens_hsa030180.68901982
88Phenylalanine metabolism_Homo sapiens_hsa003600.67932389
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.67783059
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66726630
91Estrogen signaling pathway_Homo sapiens_hsa049150.66577693
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65490212
93MAPK signaling pathway_Homo sapiens_hsa040100.65372844
94Ras signaling pathway_Homo sapiens_hsa040140.65054307
95Collecting duct acid secretion_Homo sapiens_hsa049660.63974721
96Rap1 signaling pathway_Homo sapiens_hsa040150.61462968
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61238815
98Endometrial cancer_Homo sapiens_hsa052130.61165441
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.59162254
100Regulation of autophagy_Homo sapiens_hsa041400.57542075
101Type II diabetes mellitus_Homo sapiens_hsa049300.57494381
102Inositol phosphate metabolism_Homo sapiens_hsa005620.56991895
103Renal cell carcinoma_Homo sapiens_hsa052110.56821891
104Type I diabetes mellitus_Homo sapiens_hsa049400.56170406
105Basal transcription factors_Homo sapiens_hsa030220.56021677
106Linoleic acid metabolism_Homo sapiens_hsa005910.55975714
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55010258
108Nucleotide excision repair_Homo sapiens_hsa034200.55006534
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54209426
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.54105344
111N-Glycan biosynthesis_Homo sapiens_hsa005100.53281062
112Fatty acid elongation_Homo sapiens_hsa000620.52969740
113Alzheimers disease_Homo sapiens_hsa050100.52952845
114Sphingolipid metabolism_Homo sapiens_hsa006000.51771423
115Glioma_Homo sapiens_hsa052140.51260759
116Fatty acid degradation_Homo sapiens_hsa000710.51077882
117Adherens junction_Homo sapiens_hsa045200.50499765
118Non-homologous end-joining_Homo sapiens_hsa034500.50402190
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50397273
120Ether lipid metabolism_Homo sapiens_hsa005650.49478301
121p53 signaling pathway_Homo sapiens_hsa041150.48769573
122Choline metabolism in cancer_Homo sapiens_hsa052310.48489064
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47404113
124Ovarian steroidogenesis_Homo sapiens_hsa049130.46379675
125Pathways in cancer_Homo sapiens_hsa052000.46157430
126Steroid biosynthesis_Homo sapiens_hsa001000.45906240
127Thyroid hormone synthesis_Homo sapiens_hsa049180.45595445
128Purine metabolism_Homo sapiens_hsa002300.44335152
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44282967
130Cardiac muscle contraction_Homo sapiens_hsa042600.44136292
131HTLV-I infection_Homo sapiens_hsa051660.44030404
132MicroRNAs in cancer_Homo sapiens_hsa052060.43580202
133Vibrio cholerae infection_Homo sapiens_hsa051100.43202316
134Glucagon signaling pathway_Homo sapiens_hsa049220.43193253
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43010614
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41885106
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39725976
138ECM-receptor interaction_Homo sapiens_hsa045120.39506436
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37891894
140Spliceosome_Homo sapiens_hsa030400.37359093
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37301229
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37226518
143Melanoma_Homo sapiens_hsa052180.36884544

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