LCAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.45117276
2L-phenylalanine catabolic process (GO:0006559)7.45117276
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.10528229
4L-phenylalanine metabolic process (GO:0006558)7.10528229
5aromatic amino acid family catabolic process (GO:0009074)6.62753329
6exogenous drug catabolic process (GO:0042738)6.38731374
7epoxygenase P450 pathway (GO:0019373)6.23706032
8* triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.15881964
9omega-hydroxylase P450 pathway (GO:0097267)6.08057378
10indole-containing compound catabolic process (GO:0042436)5.92161840
11indolalkylamine catabolic process (GO:0046218)5.92161840
12tryptophan catabolic process (GO:0006569)5.92161840
13kynurenine metabolic process (GO:0070189)5.82564176
14bile acid biosynthetic process (GO:0006699)5.77278065
15alpha-linolenic acid metabolic process (GO:0036109)5.71733864
16glyoxylate metabolic process (GO:0046487)5.67604290
17negative regulation of fibrinolysis (GO:0051918)5.60352147
18tryptophan metabolic process (GO:0006568)5.57003889
19regulation of plasminogen activation (GO:0010755)5.55486496
20urea cycle (GO:0000050)5.51021287
21urea metabolic process (GO:0019627)5.51021287
22* high-density lipoprotein particle remodeling (GO:0034375)5.44156588
23regulation of fibrinolysis (GO:0051917)5.40207425
24sulfur amino acid catabolic process (GO:0000098)5.39911292
25cysteine metabolic process (GO:0006534)5.37835541
26protein carboxylation (GO:0018214)5.30225082
27peptidyl-glutamic acid carboxylation (GO:0017187)5.30225082
28regulation of protein activation cascade (GO:2000257)5.20160744
29regulation of cholesterol esterification (GO:0010872)5.14535971
30complement activation, alternative pathway (GO:0006957)5.12051125
31serine family amino acid catabolic process (GO:0009071)5.08725465
32nitrogen cycle metabolic process (GO:0071941)5.05897126
33bile acid metabolic process (GO:0008206)4.94607621
34regulation of triglyceride catabolic process (GO:0010896)4.86202493
35* reverse cholesterol transport (GO:0043691)4.84401480
36regulation of complement activation (GO:0030449)4.83240563
37aromatic amino acid family metabolic process (GO:0009072)4.79128038
38* plasma lipoprotein particle remodeling (GO:0034369)4.76495733
39* protein-lipid complex remodeling (GO:0034368)4.76495733
40* macromolecular complex remodeling (GO:0034367)4.76495733
41homocysteine metabolic process (GO:0050667)4.74425458
42phospholipid efflux (GO:0033700)4.71873536
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.71863589
44tyrosine metabolic process (GO:0006570)4.69356756
45amino-acid betaine metabolic process (GO:0006577)4.65914728
46negative regulation of sterol transport (GO:0032372)4.63879719
47negative regulation of cholesterol transport (GO:0032375)4.63879719
48intestinal cholesterol absorption (GO:0030299)4.62547679
49alpha-amino acid catabolic process (GO:1901606)4.61122158
50acylglycerol homeostasis (GO:0055090)4.55810698
51triglyceride homeostasis (GO:0070328)4.55810698
52lysine catabolic process (GO:0006554)4.47692160
53lysine metabolic process (GO:0006553)4.47692160
54cellular ketone body metabolic process (GO:0046950)4.46950828
55ethanol metabolic process (GO:0006067)4.43652541
56regulation of apoptotic cell clearance (GO:2000425)4.43614602
57plasma lipoprotein particle clearance (GO:0034381)4.42118201
58low-density lipoprotein particle remodeling (GO:0034374)4.36890699
59coenzyme catabolic process (GO:0009109)4.35475030
60glutamate metabolic process (GO:0006536)4.34461054
61cholesterol efflux (GO:0033344)4.32288753
62glycine metabolic process (GO:0006544)4.29853246
63cellular amino acid catabolic process (GO:0009063)4.26630957
64cellular modified amino acid catabolic process (GO:0042219)4.25385930
65bile acid and bile salt transport (GO:0015721)4.19950321
66plasma lipoprotein particle assembly (GO:0034377)4.19674310
67imidazole-containing compound metabolic process (GO:0052803)4.18001569
68indolalkylamine metabolic process (GO:0006586)4.17251030
69dicarboxylic acid biosynthetic process (GO:0043650)4.17238487
70amine catabolic process (GO:0009310)4.16207538
71cellular biogenic amine catabolic process (GO:0042402)4.16207538
72drug metabolic process (GO:0017144)4.13865803
73negative regulation of hemostasis (GO:1900047)4.13608918
74negative regulation of blood coagulation (GO:0030195)4.13608918
75serine family amino acid metabolic process (GO:0009069)4.12703195
76cellular glucuronidation (GO:0052695)4.12622226
77acute-phase response (GO:0006953)4.07883125
78serine family amino acid biosynthetic process (GO:0009070)4.04127620
79ethanol oxidation (GO:0006069)4.01285281
80fibrinolysis (GO:0042730)3.97034794
81regulation of humoral immune response (GO:0002920)3.96813049
82benzene-containing compound metabolic process (GO:0042537)3.96241407
83arginine metabolic process (GO:0006525)3.96230529
84ketone body metabolic process (GO:1902224)3.86418074
85very-low-density lipoprotein particle assembly (GO:0034379)3.84737861
86drug catabolic process (GO:0042737)3.83370074
87blood coagulation, intrinsic pathway (GO:0007597)3.81796692
88aldehyde catabolic process (GO:0046185)3.79371577
89positive regulation of triglyceride lipase activity (GO:0061365)3.77905564
90positive regulation of lipoprotein lipase activity (GO:0051006)3.77905564
91oxidative demethylation (GO:0070989)3.77142634
92negative regulation of lipase activity (GO:0060192)3.76789835
93phospholipid homeostasis (GO:0055091)3.76295729
94positive regulation of lipid catabolic process (GO:0050996)3.75692871
95opsonization (GO:0008228)3.75540558
96negative regulation of coagulation (GO:0050819)3.75294858
97protein-lipid complex assembly (GO:0065005)3.74416230
98regulation of bile acid biosynthetic process (GO:0070857)3.74040236
99cofactor catabolic process (GO:0051187)3.73044562
100regulation of cholesterol homeostasis (GO:2000188)3.72374655
101organic acid catabolic process (GO:0016054)3.70654180
102carboxylic acid catabolic process (GO:0046395)3.70654180
103short-chain fatty acid metabolic process (GO:0046459)3.69169063
104protein activation cascade (GO:0072376)3.68219296
105complement activation, classical pathway (GO:0006958)3.67582164
106* plasma lipoprotein particle organization (GO:0071827)3.64536513
107complement activation (GO:0006956)3.63626001
108glucuronate metabolic process (GO:0019585)3.63567189
109uronic acid metabolic process (GO:0006063)3.63567189
110positive regulation of fatty acid biosynthetic process (GO:0045723)3.63381946
111negative regulation of wound healing (GO:0061045)3.62817712
112* cholesterol homeostasis (GO:0042632)3.62267505
113* sterol homeostasis (GO:0055092)3.55781254
114acetyl-CoA metabolic process (GO:0006084)3.55502462
115* protein-lipid complex subunit organization (GO:0071825)3.52860074
116flavonoid metabolic process (GO:0009812)3.52214274
117positive regulation of hemostasis (GO:1900048)3.50790768
118positive regulation of blood coagulation (GO:0030194)3.50790768
119positive regulation of fatty acid beta-oxidation (GO:0032000)3.49774423
120negative regulation of protein activation cascade (GO:2000258)3.49351602
121negative regulation of complement activation (GO:0045916)3.41001655
122disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.36105711
123killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.36105711
124regulation of cholesterol biosynthetic process (GO:0045540)3.33581641
125proline metabolic process (GO:0006560)3.30215892
126negative regulation of digestive system process (GO:0060457)3.24280674
127peptidyl-glutamic acid modification (GO:0018200)3.20857310
128positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.19984032
129* lipoprotein metabolic process (GO:0042157)3.12940520
130regulation of cholesterol metabolic process (GO:0090181)3.11854926
131positive regulation of triglyceride metabolic process (GO:0090208)3.11351345
132positive regulation of extracellular matrix organization (GO:1903055)3.11183178
133alkaloid metabolic process (GO:0009820)3.11006486
134S-adenosylmethionine metabolic process (GO:0046500)3.10956345
135cytolysis (GO:0019835)3.08960139
136acute inflammatory response (GO:0002526)3.05896682
137phenylpropanoid metabolic process (GO:0009698)3.05762637
138positive regulation of coagulation (GO:0050820)3.05087468
139negative regulation of lipid transport (GO:0032369)3.02099626
140sodium-independent organic anion transport (GO:0043252)3.01176309
141regulation of triglyceride metabolic process (GO:0090207)2.99659069
142renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.98065539

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.25090401
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.06539706
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.75680996
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.42591824
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.35294597
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.91134290
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.78019816
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.96419037
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.84790756
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12053117
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05191949
12* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8450973
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.95825295
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89074571
15* P68_20966046_ChIP-Seq_HELA_Human1.88597584
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84738447
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79380689
18DROSHA_22980978_ChIP-Seq_HELA_Human1.73990108
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71031993
20SMC4_20622854_ChIP-Seq_HELA_Human1.68608161
21* CTCF_27219007_Chip-Seq_Bcells_Human1.68589675
22FOXA2_19822575_ChIP-Seq_HepG2_Human1.64729037
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.62053980
24HTT_18923047_ChIP-ChIP_STHdh_Human1.61601452
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60039593
26VDR_21846776_ChIP-Seq_THP-1_Human1.58948328
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57559036
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.55803991
29CLOCK_20551151_ChIP-Seq_293T_Human1.53303764
30* E2F1_20622854_ChIP-Seq_HELA_Human1.51873625
31RACK7_27058665_Chip-Seq_MCF-7_Human1.48796717
32* BCOR_27268052_Chip-Seq_Bcells_Human1.48562674
33* BCL6_27268052_Chip-Seq_Bcells_Human1.46031547
34* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43149245
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39899871
36SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.39731959
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.39628873
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39210502
39HNF4A_19822575_ChIP-Seq_HepG2_Human1.38390111
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.37820874
41SA1_27219007_Chip-Seq_ERYTHROID_Human1.31328597
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.27459741
43GATA1_22025678_ChIP-Seq_K562_Human1.25878298
44KDM2B_26808549_Chip-Seq_K562_Human1.24028403
45SMC3_22415368_ChIP-Seq_MEFs_Mouse1.23051987
46* PHF8_20622854_ChIP-Seq_HELA_Human1.20269928
47* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19886775
48TP53_22127205_ChIP-Seq_IMR90_Human1.18969121
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18156676
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17405901
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14424025
52RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13737654
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12921308
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12861940
55CTCF_20526341_ChIP-Seq_ESCs_Human1.12429498
56MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09482125
57KDM2B_26808549_Chip-Seq_DND41_Human1.08716729
58SA1_27219007_Chip-Seq_Bcells_Human1.08285501
59CREB1_26743006_Chip-Seq_LNCaP_Human1.07703857
60TP63_22573176_ChIP-Seq_HFKS_Human1.07252245
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03315017
62TCF7_22412390_ChIP-Seq_EML_Mouse1.03186388
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02950480
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.01741704
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00629069
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97535628
67YY1_22570637_ChIP-Seq_MALME-3M_Human0.97156677
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95962610
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94968076
70JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94131191
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93793517
72RAC3_21632823_ChIP-Seq_H3396_Human0.93651610
73ERA_21632823_ChIP-Seq_H3396_Human0.93199554
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92855936
75KLF4_19829295_ChIP-Seq_ESCs_Human0.91800465
76OCT4_19829295_ChIP-Seq_ESCs_Human0.91253853
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90336746
78IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89188981
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89164634
80TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.88691361
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88068984
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87982482
83NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86864185
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.86808427
85SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86579653
86RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86074613
87TP53_23651856_ChIP-Seq_MEFs_Mouse0.85525031
88SMC1_22415368_ChIP-Seq_MEFs_Mouse0.85485464
89MTF2_20144788_ChIP-Seq_MESCs_Mouse0.85141771
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84981171
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84944530
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84412821
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84316292
94RUNX1_27514584_Chip-Seq_MCF-7_Human0.83761626
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.80895916
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.79869389
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76987116
98GATA4_25053715_ChIP-Seq_YYC3_Human0.75330699
99SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74963806
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73956248
101NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70219762
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70219762
103RARA_24833708_ChIP-Seq_LIVER_Mouse0.69535155
104RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66131029
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65985612
106KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65836122
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65165692
108SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64430718
109ZNF263_19887448_ChIP-Seq_K562_Human0.64243018
110IRF8_22096565_ChIP-ChIP_GC-B_Human0.63727076
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63585361
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.63568864
113NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.62467201
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.61441367
115BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61103466
116LXR_22292898_ChIP-Seq_THP-1_Human0.58691848
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.56909004
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.56632251
119RARB_24833708_ChIP-Seq_LIVER_Mouse0.55634253
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54490552
121AR_20517297_ChIP-Seq_VCAP_Human0.53860365
122* CEBPB_22108803_ChIP-Seq_LS180_Human0.52244807
123FOXA1_25552417_ChIP-Seq_VCAP_Human0.51140360
124CBP_21632823_ChIP-Seq_H3396_Human0.50640783
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49838592
126* MYC_19915707_ChIP-ChIP_AK7_Human0.49572719
127GATA1_19941826_ChIP-Seq_K562_Human0.48842410
128EGR1_19032775_ChIP-ChIP_M12_Human0.47267828
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.46233572
130GATA1_19941827_ChIP-Seq_MEL_Mouse0.45804361
131TAF2_19829295_ChIP-Seq_ESCs_Human0.45721363
132ESET_19884257_ChIP-Seq_ESCs_Mouse0.45626362
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45574770
134MYC_27129775_Chip-Seq_CORNEA_Mouse0.44952111
135* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44432389
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43964274
137* P53_21459846_ChIP-Seq_SAOS-2_Human0.42991391
138FOXO3_23340844_ChIP-Seq_DLD1_Human0.42904631
139GATA2_19941826_ChIP-Seq_K562_Human0.42588611
140* BCAT_22108803_ChIP-Seq_LS180_Human0.42554822
141FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.42508938
142PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42040523
143STAT3_1855785_ChIP-Seq_MESCs_Mouse0.41317997
144STAT1_17558387_ChIP-Seq_HELA_Human0.41035901
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40565753
146ESR1_21235772_ChIP-Seq_MCF-7_Human0.40333746
147CDX2_20551321_ChIP-Seq_CACO-2_Human0.40333689
148PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39711242
149E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.39280158
150ESR1_20079471_ChIP-ChIP_T-47D_Human0.38677779
151SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38501267
152TAF15_26573619_Chip-Seq_HEK293_Human0.37910179
153STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37407315
154ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.37358245
155P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.35950458
156DNAJC2_21179169_ChIP-ChIP_NT2_Human0.35764777
157FOXH1_21741376_ChIP-Seq_EPCs_Human0.34999862
158SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34948113
159IRF1_19129219_ChIP-ChIP_H3396_Human0.34511710
160LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34077234
161EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.34007759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.25668430
2MP0005360_urolithiasis7.42455768
3MP0005085_abnormal_gallbladder_physiolo6.33411474
4MP0005365_abnormal_bile_salt6.18747369
5MP0008875_abnormal_xenobiotic_pharmacok5.13723815
6MP0003806_abnormal_nucleotide_metabolis4.14834512
7MP0003252_abnormal_bile_duct3.79473677
8MP0009840_abnormal_foam_cell3.62285682
9* MP0010329_abnormal_lipoprotein_level3.55426700
10MP0005083_abnormal_biliary_tract3.18880693
11MP0005332_abnormal_amino_acid2.86300397
12MP0003195_calcinosis2.72774040
13MP0001666_abnormal_nutrient_absorption2.64005982
14MP0003191_abnormal_cellular_cholesterol2.38798912
15MP0008438_abnormal_cutaneous_collagen2.29962577
16MP0001986_abnormal_taste_sensitivity2.16139659
17MP0000609_abnormal_liver_physiology2.14632096
18MP0004019_abnormal_vitamin_homeostasis2.13273240
19* MP0002118_abnormal_lipid_homeostasis2.12568856
20MP0003868_abnormal_feces_composition1.97477154
21MP0005503_abnormal_tendon_morphology1.81655099
22MP0002138_abnormal_hepatobiliary_system1.80388144
23MP0005319_abnormal_enzyme/_coenzyme1.78703327
24MP0002132_abnormal_respiratory_system1.65903294
25MP0001764_abnormal_homeostasis1.64270640
26MP0005409_darkened_coat_color1.63749103
27MP0002249_abnormal_larynx_morphology1.62711405
28MP0003011_delayed_dark_adaptation1.62456870
29MP0009697_abnormal_copulation1.61107198
30MP0001958_emphysema1.52462911
31* MP0005584_abnormal_enzyme/coenzyme_acti1.51166914
32MP0003136_yellow_coat_color1.45159215
33MP0005451_abnormal_body_composition1.39839666
34MP0002282_abnormal_trachea_morphology1.36593755
35MP0002254_reproductive_system_inflammat1.36002680
36MP0003172_abnormal_lysosome_physiology1.34416328
37MP0000678_abnormal_parathyroid_gland1.26093113
38MP0000566_synostosis1.26092828
39MP0000604_amyloidosis1.25920025
40MP0003186_abnormal_redox_activity1.25784639
41MP0002933_joint_inflammation1.25737615
42MP0005171_absent_coat_pigmentation1.25230897
43MP0005647_abnormal_sex_gland1.21030300
44MP0000013_abnormal_adipose_tissue1.15746551
45MP0003705_abnormal_hypodermis_morpholog1.15624359
46MP0004272_abnormal_basement_membrane1.15140773
47MP0000751_myopathy1.14449449
48MP0003279_aneurysm1.14424572
49* MP0009643_abnormal_urine_homeostasis1.13307038
50MP0009764_decreased_sensitivity_to1.11005489
51MP0002089_abnormal_postnatal_growth/wei1.10255992
52* MP0000598_abnormal_liver_morphology1.10232697
53MP0003878_abnormal_ear_physiology1.09976114
54MP0005377_hearing/vestibular/ear_phenot1.09976114
55MP0003879_abnormal_hair_cell1.09008583
56MP0005023_abnormal_wound_healing1.08986590
57MP0003690_abnormal_glial_cell1.06836930
58MP0009780_abnormal_chondrocyte_physiolo1.02657255
59MP0000003_abnormal_adipose_tissue1.00923259
60MP0009763_increased_sensitivity_to0.99951516
61MP0000767_abnormal_smooth_muscle0.94937623
62MP0010368_abnormal_lymphatic_system0.90393128
63MP0003329_amyloid_beta_deposits0.90166495
64MP0005636_abnormal_mineral_homeostasis0.88931234
65MP0005275_abnormal_skin_tensile0.87603681
66MP0005670_abnormal_white_adipose0.87000584
67* MP0009642_abnormal_blood_homeostasis0.85091073
68* MP0003656_abnormal_erythrocyte_physiolo0.82940995
69MP0004043_abnormal_pH_regulation0.82558705
70* MP0008469_abnormal_protein_level0.80973055
71MP0005376_homeostasis/metabolism_phenot0.80296982
72MP0001915_intracranial_hemorrhage0.79457759
73MP0004130_abnormal_muscle_cell0.78448948
74MP0006036_abnormal_mitochondrial_physio0.77455673
75MP0002876_abnormal_thyroid_physiology0.77353479
76MP0002971_abnormal_brown_adipose0.75393774
77MP0002108_abnormal_muscle_morphology0.75304944
78MP0005257_abnormal_intraocular_pressure0.75215010
79MP0005408_hypopigmentation0.75209326
80* MP0002078_abnormal_glucose_homeostasis0.75194519
81MP0001502_abnormal_circadian_rhythm0.75158536
82MP0009765_abnormal_xenobiotic_induced0.74065509
83MP0005084_abnormal_gallbladder_morpholo0.73898610
84MP0005220_abnormal_exocrine_pancreas0.72847731
85MP0001661_extended_life_span0.70479376
86MP0005535_abnormal_body_temperature0.69641804
87MP0005334_abnormal_fat_pad0.66764511
88MP0005330_cardiomyopathy0.64871084
89MP0009384_cardiac_valve_regurgitation0.62826179
90MP0005266_abnormal_metabolism0.62563372
91MP0009053_abnormal_anal_canal0.62009615
92MP0005423_abnormal_somatic_nervous0.61922901
93MP0005551_abnormal_eye_electrophysiolog0.59977900
94MP0000467_abnormal_esophagus_morphology0.57540031
95MP0005375_adipose_tissue_phenotype0.57320993
96MP0005448_abnormal_energy_balance0.56855110
97MP0003075_altered_response_to0.55357512
98MP0001270_distended_abdomen0.54506430
99MP0006035_abnormal_mitochondrial_morpho0.53211633
100MP0001756_abnormal_urination0.52929725
101MP0001849_ear_inflammation0.52755094
102MP0002060_abnormal_skin_morphology0.52746315
103MP0002128_abnormal_blood_circulation0.52674722
104MP0003638_abnormal_response/metabolism_0.52175982
105MP0006138_congestive_heart_failure0.52168235
106MP0005464_abnormal_platelet_physiology0.49551339
107MP0005395_other_phenotype0.49184059
108MP0003566_abnormal_cell_adhesion0.49058687
109MP0008874_decreased_physiological_sensi0.48901965
110MP0002822_catalepsy0.48145219
111* MP0000639_abnormal_adrenal_gland0.47700934
112MP0005508_abnormal_skeleton_morphology0.47220610
113MP0005174_abnormal_tail_pigmentation0.45930971
114MP0003718_maternal_effect0.45469303
115MP0005248_abnormal_Harderian_gland0.44629422
116MP0008872_abnormal_physiological_respon0.43285549
117MP0005166_decreased_susceptibility_to0.43125758
118MP0001853_heart_inflammation0.42547165
119MP0000579_abnormal_nail_morphology0.41221985
120MP0004883_abnormal_blood_vessel0.41080687
121* MP0003953_abnormal_hormone_level0.40957144
122MP0009672_abnormal_birth_weight0.38837232
123MP0008873_increased_physiological_sensi0.38296334
124MP0005666_abnormal_adipose_tissue0.38203197
125MP0002928_abnormal_bile_duct0.37922308
126* MP0002136_abnormal_kidney_physiology0.36053977
127MP0002090_abnormal_vision0.34338520
128MP0009115_abnormal_fat_cell0.33392511
129MP0004782_abnormal_surfactant_physiolog0.32917581
130MP0002837_dystrophic_cardiac_calcinosis0.32725038
131MP0000230_abnormal_systemic_arterial0.32487099
132MP0000249_abnormal_blood_vessel0.32122119
133MP0002168_other_aberrant_phenotype0.30725580
134MP0005164_abnormal_response_to0.30349078
135MP0005167_abnormal_blood-brain_barrier0.30030305
136MP0005595_abnormal_vascular_smooth0.29782728
137MP0002796_impaired_skin_barrier0.29279662
138MP0003436_decreased_susceptibility_to0.28648076
139MP0001881_abnormal_mammary_gland0.28536881
140MP0004381_abnormal_hair_follicle0.28404133
141MP0001243_abnormal_dermal_layer0.27529966
142MP0002970_abnormal_white_adipose0.27106783
143MP0005058_abnormal_lysosome_morphology0.25780768
144MP0003724_increased_susceptibility_to0.25316840
145MP0003633_abnormal_nervous_system0.23351529

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.49179366
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.41414840
3Intrahepatic cholestasis (HP:0001406)7.19973936
4Prolonged partial thromboplastin time (HP:0003645)6.63534596
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.56201863
6Xanthomatosis (HP:0000991)6.47314140
7Hypobetalipoproteinemia (HP:0003563)6.31513141
8Complement deficiency (HP:0004431)5.24011908
9* Hyperlipoproteinemia (HP:0010980)5.07167304
10Joint hemorrhage (HP:0005261)4.82208127
11Hyperammonemia (HP:0001987)4.70513279
12* Hypolipoproteinemia (HP:0010981)4.54279546
13Hyperglycinemia (HP:0002154)4.50608466
14Abnormality of the common coagulation pathway (HP:0010990)4.47798526
15Epidermoid cyst (HP:0200040)4.44956682
16Abnormality of methionine metabolism (HP:0010901)4.39078432
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.35675034
18Ketosis (HP:0001946)4.33615366
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.16682322
20* Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.14639674
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.11350689
22Hyperglycinuria (HP:0003108)4.07051332
23Abnormality of serine family amino acid metabolism (HP:0010894)4.06081976
24Abnormality of glycine metabolism (HP:0010895)4.06081976
25Fat malabsorption (HP:0002630)4.03545467
26Hypoglycemic coma (HP:0001325)3.92250066
27* Hypoalphalipoproteinemia (HP:0003233)3.78084162
28Abnormality of complement system (HP:0005339)3.77540073
29Abnormality of the intrinsic pathway (HP:0010989)3.77498413
30Abnormality of pyrimidine metabolism (HP:0004353)3.70011822
31Hypercholesterolemia (HP:0003124)3.65567555
32Conjugated hyperbilirubinemia (HP:0002908)3.56832258
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36888247
34Abnormality of fatty-acid metabolism (HP:0004359)3.33501106
35Hyperbilirubinemia (HP:0002904)3.30592712
36Nephritis (HP:0000123)3.25822093
37Delayed CNS myelination (HP:0002188)3.13507352
38Spontaneous abortion (HP:0005268)3.09481211
39Ketoacidosis (HP:0001993)3.09289717
40Steatorrhea (HP:0002570)3.08154492
41Abnormality of serum amino acid levels (HP:0003112)3.05845212
42Abnormality of nucleobase metabolism (HP:0010932)2.97766965
43Myocardial infarction (HP:0001658)2.97281709
44Hypochromic microcytic anemia (HP:0004840)2.93054809
45Hepatocellular carcinoma (HP:0001402)2.90768383
46Metabolic acidosis (HP:0001942)2.77500420
47Thin bony cortex (HP:0002753)2.74365771
48Skin nodule (HP:0200036)2.74069045
49Protrusio acetabuli (HP:0003179)2.72111529
50Vascular calcification (HP:0004934)2.66382092
51Systemic lupus erythematosus (HP:0002725)2.64524354
52Abnormality of purine metabolism (HP:0004352)2.61644537
53Ulnar bowing (HP:0003031)2.60223474
54Hypoglycemic seizures (HP:0002173)2.59136710
55Lethargy (HP:0001254)2.59050083
56Dicarboxylic aciduria (HP:0003215)2.58962058
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.58962058
58Mesangial abnormality (HP:0001966)2.58489392
59Purpura (HP:0000979)2.57528607
60Turricephaly (HP:0000262)2.54021730
61Amyloidosis (HP:0011034)2.52007304
62Coronal craniosynostosis (HP:0004440)2.47525647
63Gout (HP:0001997)2.47205123
64Acanthocytosis (HP:0001927)2.47130755
65Abnormal gallbladder morphology (HP:0012437)2.44445991
66Mitral stenosis (HP:0001718)2.41949482
67Cerebral aneurysm (HP:0004944)2.39253407
68Glomerulonephritis (HP:0000099)2.39030634
69Cholelithiasis (HP:0001081)2.37810888
70Spastic diplegia (HP:0001264)2.37710111
71Irritability (HP:0000737)2.35911421
72Cardiovascular calcification (HP:0011915)2.35108617
73Cerebral edema (HP:0002181)2.35010496
74Cholecystitis (HP:0001082)2.31036416
75Abnormal gallbladder physiology (HP:0012438)2.31036416
76Biconcave vertebral bodies (HP:0004586)2.30042487
77Vaginal fistula (HP:0004320)2.29658416
78Arthropathy (HP:0003040)2.29229016
79Joint stiffness (HP:0001387)2.27466188
80Neonatal onset (HP:0003623)2.27452306
81Cervical subluxation (HP:0003308)2.27206691
82Gingival bleeding (HP:0000225)2.24606298
83Sensorimotor neuropathy (HP:0007141)2.23718338
84Late onset (HP:0003584)2.23301374
85Enlarged kidneys (HP:0000105)2.22565342
86Esophageal varix (HP:0002040)2.22438891
87Recurrent gram-negative bacterial infections (HP:0005420)2.16774686
88Malnutrition (HP:0004395)2.13410641
89Brushfield spots (HP:0001088)2.13284677
90Pancreatitis (HP:0001733)2.12464868
91Menorrhagia (HP:0000132)2.10499687
92Thrombophlebitis (HP:0004418)2.09792023
93Vomiting (HP:0002013)2.07681138
94Hyperinsulinemic hypoglycemia (HP:0000825)2.05691971
95Mucopolysacchariduria (HP:0008155)2.05683442
96Urinary glycosaminoglycan excretion (HP:0003541)2.05683442
97Status epilepticus (HP:0002133)2.04285632
98Generalized aminoaciduria (HP:0002909)2.01443684
99Lymphangioma (HP:0100764)2.00992386
100Opisthotonus (HP:0002179)2.00385123
101Abnormality of the gallbladder (HP:0005264)2.00085129
102Abnormality of polysaccharide metabolism (HP:0011012)1.99067198
103Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99067198
104Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99067198
105Hemorrhage of the eye (HP:0011885)1.97558546
106Poikilocytosis (HP:0004447)1.96097117
107Abnormality of proline metabolism (HP:0010907)1.92565366
108Hydroxyprolinuria (HP:0003080)1.92565366
109Peritonitis (HP:0002586)1.91564135
110Hypophosphatemic rickets (HP:0004912)1.91009137
111Widely patent fontanelles and sutures (HP:0004492)1.89747935
112Rickets (HP:0002748)1.89605676
113Bronchomalacia (HP:0002780)1.87918397
114Epistaxis (HP:0000421)1.87742410
115Abnormal delivery (HP:0001787)1.83814479
116Renal cortical cysts (HP:0000803)1.82802053
117Atrioventricular block (HP:0001678)1.81810659
118Abnormality of iron homeostasis (HP:0011031)1.81744473
119Elevated hepatic transaminases (HP:0002910)1.81603698
120Abnormality of transition element cation homeostasis (HP:0011030)1.79395530
121Alkalosis (HP:0001948)1.79204348
122Confusion (HP:0001289)1.77090820
123Back pain (HP:0003418)1.75224093
124Pulmonary embolism (HP:0002204)1.74873890
125Abnormal cartilage morphology (HP:0002763)1.72979483
126Obstructive sleep apnea (HP:0002870)1.72927603
127Abnormality of vitamin metabolism (HP:0100508)1.72397439
128Acute hepatic failure (HP:0006554)1.71995741
129Shallow orbits (HP:0000586)1.70267718
130Premature rupture of membranes (HP:0001788)1.68747988
131Delayed epiphyseal ossification (HP:0002663)1.65727983
132Hypochromic anemia (HP:0001931)1.65431023
133Rib fusion (HP:0000902)1.65143385
134Aortic aneurysm (HP:0004942)1.64917347
135Testicular atrophy (HP:0000029)1.64637944
136Increased serum ferritin (HP:0003281)1.58773598
137Intestinal fistula (HP:0100819)1.58207252
138Abnormality of the Achilles tendon (HP:0005109)1.57504402
139Elevated alkaline phosphatase (HP:0003155)1.55181174
140Broad metatarsal (HP:0001783)1.54266683
141Hypophosphatemia (HP:0002148)1.53336909
142Rectovaginal fistula (HP:0000143)1.51897293
143Rectal fistula (HP:0100590)1.51897293
144Aneurysm (HP:0002617)1.51651377
145Neonatal hypoglycemia (HP:0001998)1.50817697
146Choanal stenosis (HP:0000452)1.49716844
147Abnormality of alkaline phosphatase activity (HP:0004379)1.49519422
148Vitreoretinal degeneration (HP:0000655)1.48471957
149J-shaped sella turcica (HP:0002680)1.47629017
150Abnormal enzyme/coenzyme activity (HP:0012379)1.46348527
151Abnormality of the vitreous humor (HP:0004327)1.46208005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.08809224
2SIK14.93551957
3ERN14.50932268
4FGFR44.39926291
5INSRR3.11658935
6ERBB42.77549050
7TAOK32.66935156
8TRIB32.51488431
9MAP2K42.38178092
10WNK42.28515589
11TNK22.06088662
12NTRK32.05505237
13PKN21.94585962
14SIK21.87852498
15MAPK111.82767144
16MST1R1.82743396
17MUSK1.69587109
18DDR21.60712433
19LATS11.58248221
20FGFR21.57774946
21WNK11.55936910
22PIK3CG1.54679376
23DAPK21.54154449
24FLT31.53858249
25TYK21.49965724
26PTK61.44460924
27PINK11.39060678
28CDC42BPA1.37250244
29PDGFRA1.37047997
30EPHA41.29843578
31ABL21.29127665
32MARK21.23603086
33MAP3K71.21218881
34MAPK121.21075991
35PRKAA21.18580312
36GRK61.15598684
37JAK21.15089497
38MYLK1.14388915
39NEK91.11239450
40NLK1.10413755
41IRAK31.09841091
42KDR1.07183933
43PRKD21.06252298
44FRK1.03412850
45ERBB21.00421548
46MAPK41.00076062
47BLK0.98916904
48TYRO30.95745904
49JAK10.95107331
50PRKCZ0.93037123
51EPHB10.90681724
52MAP2K30.90257032
53MAPK70.88529614
54SGK30.87122311
55MET0.84138170
56PRKACG0.83071549
57TBK10.82031061
58CAMK2G0.81863896
59STK380.79063139
60PDGFRB0.78881799
61EPHA30.77707780
62SGK20.77521565
63CDK120.76391212
64TAOK20.75586820
65MAP3K140.72546871
66ZAP700.72527483
67CDK60.72253582
68PRKCG0.70675804
69PRKAA10.70320289
70CAMK1D0.70276680
71STK38L0.69729111
72RIPK10.69392879
73RPS6KA60.68855545
74MAP3K110.66580605
75MAP2K60.66502518
76MAP3K100.66269624
77RPS6KC10.65699339
78RPS6KL10.65699339
79PRKD10.64933711
80MAPK150.64293906
81FGFR30.64108912
82MAP3K30.63611025
83PRKD30.63537483
84RPS6KA20.63448731
85TIE10.63350521
86NTRK20.62535265
87PDK20.61772641
88MELK0.61664651
89PTK2B0.59811112
90SGK2230.59762660
91SGK4940.59762660
92CSK0.58229490
93DYRK1B0.57809040
94PDPK10.57550251
95HIPK20.57321975
96GSK3A0.56423661
97PTK20.56381163
98AKT30.54071647
99PRKCQ0.54064142
100IGF1R0.53249900
101ADRBK10.52423577
102TLK10.52294810
103PRKG10.51057961
104MAP2K20.49420603
105SMG10.49294884
106ROCK10.48715617
107CSF1R0.48199312
108TTN0.48086180
109MAP3K130.45474715
110RET0.45430975
111TRPM70.44930574
112MAP2K10.43901271
113TGFBR20.42536527
114CDK30.41724316
115CAMK10.41432312
116EEF2K0.40742435
117SGK10.40067452
118MAPK30.39415427
119GRK10.39161953
120NME10.39018920
121MAPKAPK30.38757574
122PKN10.38382642
123MAP3K50.36248383
124PRKCA0.35990767
125PDK10.35820274
126CAMK40.35542619
127IKBKE0.35410082
128BMX0.35026746
129PIK3CA0.34608253
130CSNK1G10.34351290
131CDK40.32533891
132EGFR0.32445303
133CAMK1G0.32015679
134ICK0.31210147
135PHKG20.31192232
136PHKG10.31192232
137CSNK1G20.30030488
138MTOR0.29572748
139PAK30.28732492
140FGFR10.27886339
141MAP3K60.26652154
142MAP3K10.24504789
143PRKACB0.24363560
144PRKACA0.23724717
145RPS6KA30.23222458
146PBK0.22899303

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.40719942
2Nitrogen metabolism_Homo sapiens_hsa009103.91661716
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32947443
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.22965777
5Arginine biosynthesis_Homo sapiens_hsa002203.07951504
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.79843673
7Complement and coagulation cascades_Homo sapiens_hsa046102.75540767
8Tryptophan metabolism_Homo sapiens_hsa003802.60585704
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60308665
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55613661
11Fatty acid degradation_Homo sapiens_hsa000712.54748195
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36805011
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15421131
14Butanoate metabolism_Homo sapiens_hsa006502.12976783
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06507759
16Peroxisome_Homo sapiens_hsa041462.06456006
17Fatty acid metabolism_Homo sapiens_hsa012121.92917863
18Propanoate metabolism_Homo sapiens_hsa006401.92833376
19PPAR signaling pathway_Homo sapiens_hsa033201.92116901
20Chemical carcinogenesis_Homo sapiens_hsa052041.90800848
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.88234712
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86667210
23Histidine metabolism_Homo sapiens_hsa003401.82895233
24Caffeine metabolism_Homo sapiens_hsa002321.82474061
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.77990313
26Staphylococcus aureus infection_Homo sapiens_hsa051501.69743973
27beta-Alanine metabolism_Homo sapiens_hsa004101.66615059
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.66478312
29Retinol metabolism_Homo sapiens_hsa008301.65721010
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63747899
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56921901
32Bile secretion_Homo sapiens_hsa049761.55123496
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52068755
34Phenylalanine metabolism_Homo sapiens_hsa003601.49861089
35Selenocompound metabolism_Homo sapiens_hsa004501.48041742
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45935684
37Tyrosine metabolism_Homo sapiens_hsa003501.38934797
38Steroid biosynthesis_Homo sapiens_hsa001001.36467580
39Fatty acid elongation_Homo sapiens_hsa000621.35472693
40Sulfur metabolism_Homo sapiens_hsa009201.34755081
41Other glycan degradation_Homo sapiens_hsa005111.33954602
42Pyruvate metabolism_Homo sapiens_hsa006201.33933576
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.32923410
44Starch and sucrose metabolism_Homo sapiens_hsa005001.24406246
45Biosynthesis of amino acids_Homo sapiens_hsa012301.22770173
46Folate biosynthesis_Homo sapiens_hsa007901.17737611
47Fat digestion and absorption_Homo sapiens_hsa049751.17656570
48ABC transporters_Homo sapiens_hsa020101.17137996
49Carbon metabolism_Homo sapiens_hsa012001.11166414
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08644269
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02889669
52Arginine and proline metabolism_Homo sapiens_hsa003300.99747366
53Sulfur relay system_Homo sapiens_hsa041220.99528134
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.97763800
55Vitamin B6 metabolism_Homo sapiens_hsa007500.94239304
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.93780207
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93167420
58Vitamin digestion and absorption_Homo sapiens_hsa049770.89754361
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84917759
60Fatty acid biosynthesis_Homo sapiens_hsa000610.80206525
61Lysine degradation_Homo sapiens_hsa003100.79455070
62Glycerolipid metabolism_Homo sapiens_hsa005610.72979476
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69752805
64One carbon pool by folate_Homo sapiens_hsa006700.68353318
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67158547
66Glutathione metabolism_Homo sapiens_hsa004800.59427641
67ECM-receptor interaction_Homo sapiens_hsa045120.58827262
68Pentose phosphate pathway_Homo sapiens_hsa000300.58776852
69Pertussis_Homo sapiens_hsa051330.54034599
70Metabolic pathways_Homo sapiens_hsa011000.46067728
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44558134
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40944750
73Prion diseases_Homo sapiens_hsa050200.33103395
74Fructose and mannose metabolism_Homo sapiens_hsa000510.29945830
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28925310
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27351475
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.27300269
78Amoebiasis_Homo sapiens_hsa051460.26837224
79Galactose metabolism_Homo sapiens_hsa000520.26110571
80Insulin resistance_Homo sapiens_hsa049310.24407520
81Linoleic acid metabolism_Homo sapiens_hsa005910.21841641
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21002289
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.20862491
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.19720939
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19410819
86Sphingolipid metabolism_Homo sapiens_hsa006000.18657301
87Notch signaling pathway_Homo sapiens_hsa043300.14754397
88* Glycerophospholipid metabolism_Homo sapiens_hsa005640.13871337
89Glucagon signaling pathway_Homo sapiens_hsa049220.12690816
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.06428815
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06121537
92Focal adhesion_Homo sapiens_hsa045100.05284170
93Protein digestion and absorption_Homo sapiens_hsa049740.04884890
94Cocaine addiction_Homo sapiens_hsa050300.04022662
95Choline metabolism in cancer_Homo sapiens_hsa052310.02521550
96AMPK signaling pathway_Homo sapiens_hsa041520.01842547
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.01498831
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.01364664
99Mineral absorption_Homo sapiens_hsa04978-0.2313497
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2284511
101Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2253828
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2183304
103Circadian rhythm_Homo sapiens_hsa04710-0.2103569
104Ether lipid metabolism_Homo sapiens_hsa00565-0.2098165
105Renin-angiotensin system_Homo sapiens_hsa04614-0.1903099
106Hepatitis C_Homo sapiens_hsa05160-0.1871197
107Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1826240
108Regulation of autophagy_Homo sapiens_hsa04140-0.1603129
109Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1579312
110Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1576984
111Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1576890
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1279842
113Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1127521
114Insulin signaling pathway_Homo sapiens_hsa04910-0.0996806
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0970302
116African trypanosomiasis_Homo sapiens_hsa05143-0.0765935
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0688118
118Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0605475
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0167319

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