LCE1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: LCE1A belongs to the late cornified envelope (LCE) gene cluster within the epidermal differentiation complex (EDC) on chromosome 1. The LCE cluster contains multiple conserved genes that encode stratum corneum proteins, and these genes are expressed relatively late during fetal assembly of the skin cornified envelope (Jackson et al., 2005 [PubMed 15854049]). For further information on the LCE gene cluster, see GENE FAMILY below. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water homeostasis (GO:0030104)9.33365037
2hair cycle (GO:0042633)8.83670476
3molting cycle (GO:0042303)8.83670476
4keratinocyte proliferation (GO:0043616)8.79581410
5epidermal cell differentiation (GO:0009913)8.56410535
6peptide cross-linking (GO:0018149)8.04655942
7long-chain fatty acid biosynthetic process (GO:0042759)7.55245805
8epidermis development (GO:0008544)7.33879734
9skin morphogenesis (GO:0043589)6.43016790
10lipoxygenase pathway (GO:0019372)6.37802252
11bundle of His cell to Purkinje myocyte communication (GO:0086069)6.31627731
12linoleic acid metabolic process (GO:0043651)6.27060689
13detection of bacterium (GO:0016045)5.92026094
14phosphatidylserine acyl-chain remodeling (GO:0036150)5.87802622
15phosphatidylinositol acyl-chain remodeling (GO:0036149)5.85759114
16intermediate filament organization (GO:0045109)5.83807867
17positive regulation of cellular amide metabolic process (GO:0034250)5.76782156
18detection of other organism (GO:0098543)5.38832744
19intermediate filament cytoskeleton organization (GO:0045104)4.92845862
20phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.83290384
21intermediate filament-based process (GO:0045103)4.77263965
22phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.76407721
23surfactant homeostasis (GO:0043129)4.72033635
24regulation of transforming growth factor beta1 production (GO:0032908)4.54902407
25regulation of natural killer cell differentiation (GO:0032823)4.51307236
26hemidesmosome assembly (GO:0031581)4.44648027
27keratinocyte development (GO:0003334)4.40971732
28negative regulation of interferon-gamma production (GO:0032689)4.29927762
29phosphatidylcholine acyl-chain remodeling (GO:0036151)4.28225852
30positive regulation of interleukin-8 secretion (GO:2000484)4.26873763
31ectoderm development (GO:0007398)4.17798580
32chemical homeostasis within a tissue (GO:0048875)4.15026839
33positive regulation of glomerulus development (GO:0090193)4.06932253
34ceramide biosynthetic process (GO:0046513)3.92109693
35defense response to Gram-negative bacterium (GO:0050829)3.86655084
36fatty acid elongation (GO:0030497)3.85862344
37defense response to fungus (GO:0050832)3.85038365
38positive regulation of cholesterol efflux (GO:0010875)3.79703067
39phospholipid efflux (GO:0033700)3.68489190
40regulation of cell proliferation involved in kidney development (GO:1901722)3.65802011
41phosphatidylserine metabolic process (GO:0006658)3.58667687
42positive regulation of epidermal cell differentiation (GO:0045606)3.53404469
43negative regulation of interleukin-17 production (GO:0032700)3.53326592
44positive regulation of epidermis development (GO:0045684)3.50264294
45positive regulation of humoral immune response (GO:0002922)3.47494147
46establishment of planar polarity (GO:0001736)3.46124164
47establishment of tissue polarity (GO:0007164)3.46124164
48epithelium development (GO:0060429)3.43957525
49positive regulation of p38MAPK cascade (GO:1900745)3.34340072
50positive regulation of cholesterol transport (GO:0032376)3.31885242
51positive regulation of sterol transport (GO:0032373)3.31885242
52regulation of keratinocyte differentiation (GO:0045616)3.30085405
53antimicrobial humoral response (GO:0019730)3.24065294
54negative regulation of keratinocyte proliferation (GO:0010839)3.20255908
55* keratinization (GO:0031424)28.2337261
56establishment of skin barrier (GO:0061436)20.6564112
57detection of external biotic stimulus (GO:0098581)2.99905122
58polarized epithelial cell differentiation (GO:0030859)2.99552582
59lateral sprouting from an epithelium (GO:0060601)2.99241786
60positive regulation of keratinocyte differentiation (GO:0045618)2.96936141
61epithelial cell differentiation involved in prostate gland development (GO:0060742)2.90263072
62positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.88240455
63regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.88240455
64regulation of cellular amide metabolic process (GO:0034248)2.87229649
65regulation of epidermis development (GO:0045682)2.85058802
66alditol phosphate metabolic process (GO:0052646)2.85056160
67phospholipid catabolic process (GO:0009395)2.81423640
68regulation of interleukin-8 secretion (GO:2000482)2.78407026
69regulation of epidermal cell differentiation (GO:0045604)2.74670952
70regulation of p38MAPK cascade (GO:1900744)2.73563345
71positive regulation of T-helper 1 type immune response (GO:0002827)2.72571975
72gap junction assembly (GO:0016264)2.69216074
73regulation of cholesterol homeostasis (GO:2000188)2.64692950
74regulation of axon regeneration (GO:0048679)2.60351927
75regulation of neuron projection regeneration (GO:0070570)2.60351927
76sphingolipid biosynthetic process (GO:0030148)2.60181909
77regulation of keratinocyte proliferation (GO:0010837)2.57552937
78regulation of glomerulus development (GO:0090192)2.57074912
79response to fungus (GO:0009620)2.53947235
80regulation of protein localization to cell surface (GO:2000008)2.53801149
81detection of biotic stimulus (GO:0009595)2.53309788
82phosphatidylglycerol metabolic process (GO:0046471)2.49710017
83positive regulation of transforming growth factor beta production (GO:0071636)2.49587165
84hair follicle morphogenesis (GO:0031069)2.44769275
85skin development (GO:0043588)2.43047583
86regulation of cholesterol efflux (GO:0010874)2.42625403
87ventricular cardiac muscle cell action potential (GO:0086005)2.40659284
88planar cell polarity pathway involved in neural tube closure (GO:0090179)2.38898122
89atrioventricular valve morphogenesis (GO:0003181)2.34152433
90eyelid development in camera-type eye (GO:0061029)2.32200884
91one-carbon compound transport (GO:0019755)2.32121229
92regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.31579120
93epithelial cell differentiation (GO:0030855)2.31526738
94epithelial cell-cell adhesion (GO:0090136)2.30980093
95polyol transport (GO:0015791)2.28459977
96regulation of hair cycle (GO:0042634)2.28419300
97regulation of water loss via skin (GO:0033561)17.7015530
98desmosome organization (GO:0002934)12.1863397
99multicellular organismal water homeostasis (GO:0050891)11.1996662
100keratinocyte differentiation (GO:0030216)10.5987432

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.32952143
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.57221075
3P63_26484246_Chip-Seq_KERATINOCYTES_Human4.55759071
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.82470043
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.79378722
6HIF1A_21447827_ChIP-Seq_MCF-7_Human2.74990034
7SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.61561140
8SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.61561140
9SOX9_24532713_ChIP-Seq_HFSC_Mouse2.56086337
10TP63_23658742_ChIP-Seq_EP156T_Human2.17399463
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.15749676
12RXR_22108803_ChIP-Seq_LS180_Human2.14902318
13FOXO3_23340844_ChIP-Seq_DLD1_Human2.06123147
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.02882699
15TP63_17297297_ChIP-ChIP_HaCaT_Human13.1088253
16* TP63_22573176_ChIP-Seq_HFKS_Human1.88904648
17* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.73883793
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67099454
19EGR1_19032775_ChIP-ChIP_M12_Human1.57891534
20GATA6_21074721_ChIP-Seq_CACO-2_Human1.56694214
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49545519
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49091382
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45926549
24* CTCF_27219007_Chip-Seq_Bcells_Human1.42470236
25ATF3_27146783_Chip-Seq_COLON_Human1.38574542
26KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34170799
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32066902
28UBF1/2_26484160_Chip-Seq_HMECs_Human1.30880728
29KLF5_25053715_ChIP-Seq_YYC3_Human1.27107150
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24074205
31GATA3_24758297_ChIP-Seq_MCF-7_Human1.23679046
32TCF4_18268006_ChIP-ChIP_LS174T_Human1.21420374
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.19648878
34RACK7_27058665_Chip-Seq_MCF-7_Human1.18725528
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.16467539
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14604562
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12497946
38FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10575373
39VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10229523
40JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08751602
41FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07600992
42ERG_20517297_ChIP-Seq_VCAP_Human1.07411729
43SOX2_20726797_ChIP-Seq_SW620_Human1.06211906
44UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04524175
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01495562
46SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99261221
47BCOR_27268052_Chip-Seq_Bcells_Human0.97867004
48P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.97300025
49TP53_18474530_ChIP-ChIP_U2OS_Human0.96716745
50BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95889167
51* CTCF_20526341_ChIP-Seq_ESCs_Human0.95747939
52P53_21459846_ChIP-Seq_SAOS-2_Human0.93928127
53CJUN_26792858_Chip-Seq_BT549_Human0.92949177
54SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92217136
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92084390
56JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91879479
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91538331
58AR_21572438_ChIP-Seq_LNCaP_Human0.91212220
59ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90432790
60DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89975982
61ZNF263_19887448_ChIP-Seq_K562_Human0.89568382
62SMC4_20622854_ChIP-Seq_HELA_Human0.89480047
63* E2F1_20622854_ChIP-Seq_HELA_Human0.89298427
64* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87336740
65ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87185686
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86883647
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85005359
68GATA4_25053715_ChIP-Seq_YYC3_Human0.82739748
69PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82671843
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82384186
71HNFA_21074721_ChIP-Seq_CACO-2_Human0.81339122
72PPARA_22158963_ChIP-Seq_LIVER_Mouse0.80779064
73GATA6_25053715_ChIP-Seq_YYC3_Human0.80527274
74AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80070207
75LXR_22292898_ChIP-Seq_THP-1_Human0.78495913
76CLOCK_20551151_ChIP-Seq_293T_Human0.77767936
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77287456
78* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.74639901
79RBPJ_21746931_ChIP-Seq_IB4_Human0.73773317
80ELK3_25401928_ChIP-Seq_HUVEC_Human0.72872029
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72797307
82CEBPB_22108803_ChIP-Seq_LS180_Human0.72724866
83AHR_22903824_ChIP-Seq_MCF-7_Human0.72555669
84SA1_27219007_Chip-Seq_ERYTHROID_Human0.70371553
85TP53_16413492_ChIP-PET_HCT116_Human0.69996282
86MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.69116225
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68511107
88GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.66739419
89* SMAD4_21741376_ChIP-Seq_ESCs_Human0.64499365
90NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64417446
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64417446
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.64152137
93* YY1_22570637_ChIP-Seq_MALME-3M_Human0.64037414
94FOXA1_25552417_ChIP-Seq_VCAP_Human0.63565327
95KDM2B_26808549_Chip-Seq_K562_Human0.63286594
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.62610520
97TAF2_19829295_ChIP-Seq_ESCs_Human0.62253479
98JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.61720504
99* P68_20966046_ChIP-Seq_HELA_Human0.60939131
100P300_27058665_Chip-Seq_ZR-75-30cells_Human0.58449773

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile7.11078201
2MP0010234_abnormal_vibrissa_follicle5.83332499
3MP0005501_abnormal_skin_physiology5.65483532
4MP0000579_abnormal_nail_morphology4.87946693
5MP0003941_abnormal_skin_development4.16229833
6MP0009379_abnormal_foot_pigmentation3.40822429
7MP0001216_abnormal_epidermal_layer3.27166515
8MP0003453_abnormal_keratinocyte_physiol3.12893625
9MP0004947_skin_inflammation2.94509157
10MP0010771_integument_phenotype2.92172900
11MP0010678_abnormal_skin_adnexa2.88519079
12MP0004381_abnormal_hair_follicle2.80404859
13MP0003191_abnormal_cellular_cholesterol2.69729236
14MP0000383_abnormal_hair_follicle2.60114075
15MP0002060_abnormal_skin_morphology2.56809138
16MP0002098_abnormal_vibrissa_morphology2.30199505
17MP0000377_abnormal_hair_follicle2.23413159
18MP0000566_synostosis2.11606993
19MP0004782_abnormal_surfactant_physiolog2.03289785
20MP0002796_impaired_skin_barrier10.2034305
21MP0001188_hyperpigmentation1.90771794
22MP0003705_abnormal_hypodermis_morpholog1.85828485
23MP0000467_abnormal_esophagus_morphology1.84310406
24MP0005409_darkened_coat_color1.79671239
25MP0009931_abnormal_skin_appearance1.77973310
26MP0003011_delayed_dark_adaptation1.70895819
27MP0000647_abnormal_sebaceous_gland1.56645762
28MP0001191_abnormal_skin_condition1.42691737
29MP0000367_abnormal_coat/_hair1.35303550
30MP0002095_abnormal_skin_pigmentation1.34341877
31MP0003566_abnormal_cell_adhesion1.25497854
32MP0004885_abnormal_endolymph1.24154567
33MP0000427_abnormal_hair_cycle1.22551919
34MP0003878_abnormal_ear_physiology1.18705011
35MP0005377_hearing/vestibular/ear_phenot1.18705011
36MP0000762_abnormal_tongue_morphology1.18238565
37MP0000015_abnormal_ear_pigmentation1.16194848
38MP0005174_abnormal_tail_pigmentation1.05301937
39MP0000465_gastrointestinal_hemorrhage1.04900793
40MP0001784_abnormal_fluid_regulation0.89959999
41MP0001243_abnormal_dermal_layer0.89575067
42MP0010352_gastrointestinal_tract_polyps0.88319741
43MP0003950_abnormal_plasma_membrane0.86094177
44MP0004264_abnormal_extraembryonic_tissu0.85354352
45MP0009053_abnormal_anal_canal0.84240910
46MP0005023_abnormal_wound_healing0.82803155
47MP0001851_eye_inflammation0.77996526
48MP0002177_abnormal_outer_ear0.71047075
49MP0002234_abnormal_pharynx_morphology0.62106890
50MP0004185_abnormal_adipocyte_glucose0.56163643
51MP0001984_abnormal_olfaction0.50101476
52MP0005075_abnormal_melanosome_morpholog0.48654732
53MP0001340_abnormal_eyelid_morphology0.47369292
54MP0009333_abnormal_splenocyte_physiolog0.44187444
55MP0001177_atelectasis0.42828315
56MP0009780_abnormal_chondrocyte_physiolo0.40429807
57MP0003763_abnormal_thymus_physiology0.38882656
58MP0005076_abnormal_cell_differentiation0.38695329
59MP0003315_abnormal_perineum_morphology0.37712427
60MP0002009_preneoplasia0.37641733
61MP0010030_abnormal_orbit_morphology0.36142145
62MP0008004_abnormal_stomach_pH0.35613610
63MP0008789_abnormal_olfactory_epithelium0.35088074
64MP0005388_respiratory_system_phenotype0.32768300
65MP0002133_abnormal_respiratory_system0.32768300
66MP0005499_abnormal_olfactory_system0.30768584
67MP0005394_taste/olfaction_phenotype0.30768584
68MP0003638_abnormal_response/metabolism_0.29289878
69MP0000627_abnormal_mammary_gland0.28589407
70MP0002111_abnormal_tail_morphology0.28229984
71MP0004272_abnormal_basement_membrane0.24759761
72MP0003755_abnormal_palate_morphology0.23167085
73MP0009672_abnormal_birth_weight0.22845494
74MP0005257_abnormal_intraocular_pressure0.20663978
75MP0000685_abnormal_immune_system0.20365360
76MP0005375_adipose_tissue_phenotype0.20316166
77MP0002697_abnormal_eye_size0.19600350
78MP0004197_abnormal_fetal_growth/weight/0.19541379
79MP0005666_abnormal_adipose_tissue0.18995797
80MP0001502_abnormal_circadian_rhythm0.18217074
81MP0003828_pulmonary_edema0.18001842
82MP0002233_abnormal_nose_morphology0.16780797
83MP0001186_pigmentation_phenotype0.15383067
84MP0002282_abnormal_trachea_morphology0.13996623
85MP0003221_abnormal_cardiomyocyte_apopto0.13339067
86MP0001756_abnormal_urination0.11946505
87MP0002138_abnormal_hepatobiliary_system0.10886169
88MP0000432_abnormal_head_morphology0.10486460
89MP0005193_abnormal_anterior_eye0.08677353
90MP0001299_abnormal_eye_distance/0.08611124
91MP0008260_abnormal_autophagy0.08529104
92MP0002006_tumorigenesis0.08113331
93MP0003300_gastrointestinal_ulcer0.07275226
94MP0008569_lethality_at_weaning0.06540450
95MP0005647_abnormal_sex_gland0.04865225
96MP0002136_abnormal_kidney_physiology0.04540254
97MP0005248_abnormal_Harderian_gland0.04326835
98MP0004510_myositis0.04152948
99MP0005508_abnormal_skeleton_morphology0.04083114
100MP0003448_altered_tumor_morphology0.03911986

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.65930862
2Congenital ichthyosiform erythroderma (HP:0007431)8.98048422
3Congenital nonbullous ichthyosiform erythroderma (HP:0007479)8.76678363
4Palmoplantar hyperkeratosis (HP:0000972)8.36686172
5Palmar hyperkeratosis (HP:0010765)7.94880403
6Erythroderma (HP:0001019)7.82766016
7Parakeratosis (HP:0001036)7.04475697
8Plantar hyperkeratosis (HP:0007556)6.91721417
9Erythema (HP:0010783)6.91153051
10Hypotrichosis (HP:0001006)6.52166165
11Thick nail (HP:0001805)6.29185697
12Onycholysis (HP:0001806)5.71378751
13Alopecia of scalp (HP:0002293)5.62125780
14Corneal erosion (HP:0200020)5.55762568
15Oral leukoplakia (HP:0002745)5.49582574
16Abnormality of secondary sexual hair (HP:0009888)4.99035710
17Abnormality of the axillary hair (HP:0100134)4.99035710
18Palmoplantar keratoderma (HP:0000982)4.76173021
19Gangrene (HP:0100758)4.51571536
20Ectropion (HP:0000656)4.50076988
21Hypohidrosis (HP:0000966)4.32931302
22Right ventricular cardiomyopathy (HP:0011663)4.21860130
23Fragile nails (HP:0001808)4.14285076
24Conjunctival hamartoma (HP:0100780)4.07666043
25Woolly hair (HP:0002224)4.06054207
26Abnormal blistering of the skin (HP:0008066)3.67039768
27Eczematoid dermatitis (HP:0000976)3.63974739
28Nail dystrophy (HP:0008404)3.58718508
29Lip pit (HP:0100267)3.57731220
30Pruritus (HP:0000989)3.37958426
31Follicular hyperkeratosis (HP:0007502)3.36842213
32Abnormality of the salivary glands (HP:0010286)3.31872691
33Sparse eyelashes (HP:0000653)3.14388732
34Sparse scalp hair (HP:0002209)3.12668035
35Absent eyelashes (HP:0000561)2.92930172
36Hamartoma of the eye (HP:0010568)2.72655207
37Lack of skin elasticity (HP:0100679)2.70080263
38Pili torti (HP:0003777)2.63105701
39Natal tooth (HP:0000695)2.57911318
40Abnormal hair laboratory examination (HP:0003328)2.55459592
41Hyperhidrosis (HP:0000975)2.54501615
42Pustule (HP:0200039)2.49791108
43Hypergammaglobulinemia (HP:0010702)2.45620413
44Laryngomalacia (HP:0001601)2.44320988
45Absent hair (HP:0002298)2.39860219
46Dehydration (HP:0001944)2.32046311
47Milia (HP:0001056)2.28846497
48Furrowed tongue (HP:0000221)2.28174838
49Advanced eruption of teeth (HP:0006288)2.21793893
50Blepharitis (HP:0000498)2.20432490
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15496270
52Hypoplastic labia majora (HP:0000059)2.14840090
53Acanthosis nigricans (HP:0000956)2.01360416
54Abnormality of nail color (HP:0100643)11.9279693
55Axonal loss (HP:0003447)1.99150241
56Anonychia (HP:0001798)1.98906538
57Dry skin (HP:0000958)1.97163963
58Abnormality of the labia majora (HP:0012881)1.95940502
59Ridged nail (HP:0001807)1.89556094
60Sepsis (HP:0100806)1.84762658
61Corneal dystrophy (HP:0001131)1.83081134
62Split foot (HP:0001839)1.82549968
63Segmental peripheral demyelination/remyelination (HP:0003481)1.81714985
64Conical tooth (HP:0000698)1.81267324
65Melanocytic nevus (HP:0000995)1.81113513
66Skin ulcer (HP:0200042)1.79648346
67Curly hair (HP:0002212)1.78216337
68Brittle hair (HP:0002299)1.76435867
69Duplicated collecting system (HP:0000081)1.65919641
70Autoamputation (HP:0001218)1.65250514
71Xerostomia (HP:0000217)1.61141075
72Selective tooth agenesis (HP:0001592)1.60498516
73Abnormality of hair growth rate (HP:0011363)1.57567494
74Slow-growing hair (HP:0002217)1.57567494
75Nasolacrimal duct obstruction (HP:0000579)1.57311947
76Carious teeth (HP:0000670)1.56858759
77Hamartoma (HP:0010566)1.56449747
78Verrucae (HP:0200043)1.56028411
79Papilloma (HP:0012740)1.56028411
80Ventricular tachycardia (HP:0004756)1.53001530
81Septate vagina (HP:0001153)1.51390906
82Urticaria (HP:0001025)1.50693709
83Paralysis (HP:0003470)1.50686962
84Multifactorial inheritance (HP:0001426)1.50247617
85Amniotic constriction ring (HP:0009775)1.49637498
86Abnormality of placental membranes (HP:0011409)1.49637498
87Abnormality of the dental root (HP:0006486)1.48736197
88Taurodontia (HP:0000679)1.48736197
89Abnormality of permanent molar morphology (HP:0011071)1.48736197
90Popliteal pterygium (HP:0009756)1.44230233
91Recurrent corneal erosions (HP:0000495)1.44187743
92Abnormality of the fingernails (HP:0001231)1.44097772
93Depressed nasal tip (HP:0000437)1.42987243
94Neonatal death (HP:0003811)1.42137414
95Oligodontia (HP:0000677)1.42002183
96Abnormality of the renal collecting system (HP:0004742)1.40627265
97Abnormality of molar (HP:0011077)1.38816481
98Abnormality of molar morphology (HP:0011070)1.38816481
99Malignant hyperthermia (HP:0002047)1.37906049
100Anhidrosis (HP:0000970)1.33805591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.54466249
2TGFBR14.11661450
3STK243.83218491
4MAP3K63.61090752
5FGFR13.36912745
6EEF2K3.11156889
7SGK4942.82059774
8SGK2232.82059774
9FER2.71668106
10MAPKAPK32.68379189
11MAP3K92.18345901
12FGFR31.89075026
13MST1R1.83289892
14RIPK11.77374332
15MAP3K31.72108846
16MAP3K21.69083862
17LATS11.60338796
18IRAK11.48660766
19EPHA31.33654796
20WNK11.31694500
21MAP3K11.30917526
22TRPM71.27475408
23PRPF4B1.25078542
24PIM21.24115897
25ERN11.23316244
26ABL21.22211672
27TGFBR21.19338860
28MARK21.18552553
29EPHB11.15424994
30MET1.14982350
31STK38L1.14721416
32AKT31.10023689
33PIK3CG1.07748701
34SGK21.06259066
35IRAK21.06152441
36LATS21.04413253
37IKBKB1.03871784
38MAP2K61.02313238
39ADRBK11.02156269
40MAPKAPK51.01648341
41GSK3A0.93035787
42MAP3K70.91028922
43MOS0.90207487
44STK30.89832358
45PTK20.89596270
46SGK30.87318587
47MAPK70.87304922
48IRAK40.84283123
49TAOK10.83241364
50MAPK150.81872740
51IKBKE0.81652384
52MAPK120.79902919
53MTOR0.78408470
54CDK120.77386273
55GRK70.75398571
56PKN10.73697370
57GRK60.69714405
58RPS6KB20.68007587
59PDGFRB0.67597239
60DYRK30.65612244
61PRKD20.65119824
62MAP3K120.62108634
63SGK10.61230169
64NLK0.57773726
65PRKAA20.54855634
66BMX0.54321057
67RPS6KB10.54293893
68STK100.49079276
69MAPKAPK20.48963332
70CDK60.45067688
71MAP2K40.44491418
72PBK0.41435688
73STK380.38907170
74FGFR20.38685365
75EPHB20.38292621
76MAPK40.38261351
77MAP3K50.35305290
78TAOK30.35008056
79HCK0.33966850
80SIK10.33486629
81CHUK0.31851071
82DYRK1B0.31446965
83MINK10.29402471
84PAK20.28880794
85ABL10.27486702
86MST40.27298601
87EPHA40.27290461
88MAP2K10.26604305
89GRK50.25340703
90PDGFRA0.24320122
91ICK0.24213938
92NEK60.22577225
93FGFR40.22539616
94RET0.21143981
95KSR20.20877908
96PRKCE0.19006998
97IRAK30.18936499
98MAPK90.18728183
99TBK10.16831472
100MAPK80.16499834

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005927.13649504
2Linoleic acid metabolism_Homo sapiens_hsa005915.59592020
3Ether lipid metabolism_Homo sapiens_hsa005653.87369525
4Arachidonic acid metabolism_Homo sapiens_hsa005903.35211804
5Sphingolipid metabolism_Homo sapiens_hsa006002.86572965
6GnRH signaling pathway_Homo sapiens_hsa049122.27060804
7Circadian rhythm_Homo sapiens_hsa047102.11044465
8Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.06720212
9Ovarian steroidogenesis_Homo sapiens_hsa049131.95064113
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83322509
11VEGF signaling pathway_Homo sapiens_hsa043701.81556415
12Long-term depression_Homo sapiens_hsa047301.74406095
13Phototransduction_Homo sapiens_hsa047441.67498531
14Vascular smooth muscle contraction_Homo sapiens_hsa042701.67261332
15Glycerophospholipid metabolism_Homo sapiens_hsa005641.57215892
16Fatty acid elongation_Homo sapiens_hsa000621.49590968
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48975722
18Dorso-ventral axis formation_Homo sapiens_hsa043201.43058235
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36655094
20Histidine metabolism_Homo sapiens_hsa003401.34289621
21Ras signaling pathway_Homo sapiens_hsa040141.22371018
22Staphylococcus aureus infection_Homo sapiens_hsa051501.20607786
23Serotonergic synapse_Homo sapiens_hsa047261.17047747
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16108340
25Choline metabolism in cancer_Homo sapiens_hsa052311.14876043
26Fat digestion and absorption_Homo sapiens_hsa049751.13213354
27Renin secretion_Homo sapiens_hsa049241.07337892
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04609417
29Amoebiasis_Homo sapiens_hsa051461.01698747
30p53 signaling pathway_Homo sapiens_hsa041151.01172789
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99940719
32Sphingolipid signaling pathway_Homo sapiens_hsa040710.95270885
33ABC transporters_Homo sapiens_hsa020100.89269599
34Acute myeloid leukemia_Homo sapiens_hsa052210.85639069
35Platelet activation_Homo sapiens_hsa046110.78867667
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78790693
37Oxytocin signaling pathway_Homo sapiens_hsa049210.77908948
38Tight junction_Homo sapiens_hsa045300.77254613
39Phenylalanine metabolism_Homo sapiens_hsa003600.74360672
40Retinol metabolism_Homo sapiens_hsa008300.73153597
41Inositol phosphate metabolism_Homo sapiens_hsa005620.72262294
42Phospholipase D signaling pathway_Homo sapiens_hsa040720.71504333
43Glioma_Homo sapiens_hsa052140.70878737
44MicroRNAs in cancer_Homo sapiens_hsa052060.68539752
45Endocytosis_Homo sapiens_hsa041440.66499342
46Glutamatergic synapse_Homo sapiens_hsa047240.65747517
47Estrogen signaling pathway_Homo sapiens_hsa049150.65524791
48Adherens junction_Homo sapiens_hsa045200.65484628
49MAPK signaling pathway_Homo sapiens_hsa040100.65180527
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65103262
51ECM-receptor interaction_Homo sapiens_hsa045120.64622340
52Long-term potentiation_Homo sapiens_hsa047200.63148523
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.63012020
54Melanogenesis_Homo sapiens_hsa049160.62866081
55Pertussis_Homo sapiens_hsa051330.62613203
56Renal cell carcinoma_Homo sapiens_hsa052110.62324358
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60134394
58Pancreatic secretion_Homo sapiens_hsa049720.59733488
59Notch signaling pathway_Homo sapiens_hsa043300.58842683
60Bladder cancer_Homo sapiens_hsa052190.57189995
61ErbB signaling pathway_Homo sapiens_hsa040120.54290925
62Gastric acid secretion_Homo sapiens_hsa049710.53158588
63Salivary secretion_Homo sapiens_hsa049700.50913547
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50701655
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.50616270
66Hepatitis C_Homo sapiens_hsa051600.48222107
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47974769
68Toxoplasmosis_Homo sapiens_hsa051450.46697183
69Rap1 signaling pathway_Homo sapiens_hsa040150.44355585
70Tuberculosis_Homo sapiens_hsa051520.41637137
71Circadian entrainment_Homo sapiens_hsa047130.40660720
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39828432
73Insulin signaling pathway_Homo sapiens_hsa049100.38751951
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37817219
75HIF-1 signaling pathway_Homo sapiens_hsa040660.35831183
76Thyroid cancer_Homo sapiens_hsa052160.35710491
77Amphetamine addiction_Homo sapiens_hsa050310.34517065
78Calcium signaling pathway_Homo sapiens_hsa040200.33976409
79Glucagon signaling pathway_Homo sapiens_hsa049220.33788085
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33278996
81Axon guidance_Homo sapiens_hsa043600.32473368
82FoxO signaling pathway_Homo sapiens_hsa040680.31716187
83Collecting duct acid secretion_Homo sapiens_hsa049660.31563366
84Hippo signaling pathway_Homo sapiens_hsa043900.31133737
85PPAR signaling pathway_Homo sapiens_hsa033200.30977696
86Proteoglycans in cancer_Homo sapiens_hsa052050.30507005
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30431846
88Pathways in cancer_Homo sapiens_hsa052000.28281070
89Salmonella infection_Homo sapiens_hsa051320.26186375
90Influenza A_Homo sapiens_hsa051640.24791458
91TGF-beta signaling pathway_Homo sapiens_hsa043500.22303779
92Nitrogen metabolism_Homo sapiens_hsa009100.22276959
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21827229
94Mineral absorption_Homo sapiens_hsa049780.21824304
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.21734279
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21733497
97Dopaminergic synapse_Homo sapiens_hsa047280.20369452
98Shigellosis_Homo sapiens_hsa051310.19404726
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.18942087
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.18411115

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