LCE1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1molting cycle (GO:0042303)9.48166952
2hair cycle (GO:0042633)9.48166952
3hemidesmosome assembly (GO:0031581)8.83415361
4multicellular organismal water homeostasis (GO:0050891)8.73340450
5keratinocyte differentiation (GO:0030216)8.60700073
6peptide cross-linking (GO:0018149)8.60298599
7water homeostasis (GO:0030104)7.28520497
8positive regulation of cellular amide metabolic process (GO:0034250)7.11305813
9epidermal cell differentiation (GO:0009913)6.68594478
10long-chain fatty acid biosynthetic process (GO:0042759)6.34892139
11bundle of His cell to Purkinje myocyte communication (GO:0086069)6.23731512
12intermediate filament organization (GO:0045109)6.12946404
13skin morphogenesis (GO:0043589)6.05159609
14regulation of type B pancreatic cell apoptotic process (GO:2000674)5.95440810
15epidermis development (GO:0008544)5.70744264
16keratinocyte proliferation (GO:0043616)5.69561883
17glucosamine-containing compound catabolic process (GO:1901072)5.68673873
18regulation of transforming growth factor beta1 production (GO:0032908)5.54536211
19G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.22364925
20positive regulation of glomerulus development (GO:0090193)4.97348700
21fatty acid elongation (GO:0030497)4.71567212
22surfactant homeostasis (GO:0043129)4.62892146
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.61771152
24ectoderm development (GO:0007398)4.51424382
25defense response to Gram-negative bacterium (GO:0050829)4.46595925
26defense response to fungus (GO:0050832)4.46255888
27regulation of cell proliferation involved in kidney development (GO:1901722)4.38760034
28regulation of hypersensitivity (GO:0002883)4.36571471
29positive regulation of humoral immune response (GO:0002922)4.34476906
30regulation of ruffle assembly (GO:1900027)4.33483936
31linoleic acid metabolic process (GO:0043651)4.22191968
32chemical homeostasis within a tissue (GO:0048875)4.17074628
33positive regulation of cholesterol efflux (GO:0010875)4.15124190
34negative regulation of interferon-gamma production (GO:0032689)4.08005237
35positive regulation of p38MAPK cascade (GO:1900745)4.07080535
36intermediate filament cytoskeleton organization (GO:0045104)3.98067191
37negative regulation of catenin import into nucleus (GO:0035414)3.95130902
38regulation of natural killer cell differentiation (GO:0032823)3.91542431
39phosphatidylcholine acyl-chain remodeling (GO:0036151)3.90883756
40intermediate filament-based process (GO:0045103)3.84168776
41antimicrobial humoral response (GO:0019730)3.72539624
42phospholipid efflux (GO:0033700)3.70351084
43ceramide biosynthetic process (GO:0046513)3.66688193
44negative regulation of interleukin-17 production (GO:0032700)3.66279182
45positive regulation of sterol transport (GO:0032373)3.66116383
46positive regulation of cholesterol transport (GO:0032376)3.66116383
47positive regulation of T-helper 1 type immune response (GO:0002827)3.56990110
48regulation of cellular amide metabolic process (GO:0034248)3.55838963
49regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.54422579
50positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.54422579
51skin development (GO:0043588)3.46889807
52establishment of tissue polarity (GO:0007164)3.46316375
53establishment of planar polarity (GO:0001736)3.46316375
54regulation of interleukin-8 secretion (GO:2000482)3.45489610
55positive regulation of epidermal cell differentiation (GO:0045606)3.44942131
56lipoxygenase pathway (GO:0019372)3.44344144
57lateral sprouting from an epithelium (GO:0060601)3.43623801
58keratinocyte development (GO:0003334)3.41808409
59regulation of receptor recycling (GO:0001919)3.40646098
60polarized epithelial cell differentiation (GO:0030859)3.36232387
61negative regulation of cell fate specification (GO:0009996)3.35950681
62fibrinolysis (GO:0042730)3.35400146
63positive regulation of keratinocyte differentiation (GO:0045618)3.32469131
64cellular response to calcium ion (GO:0071277)3.29173464
65phosphatidylinositol acyl-chain remodeling (GO:0036149)3.28920260
66phosphatidylserine acyl-chain remodeling (GO:0036150)3.22098707
67negative regulation of muscle hypertrophy (GO:0014741)3.22036096
68positive regulation of interleukin-8 secretion (GO:2000484)3.20570677
69regulation of glomerulus development (GO:0090192)3.19345226
70thymic T cell selection (GO:0045061)3.19084135
71epithelial cell differentiation involved in prostate gland development (GO:0060742)3.15458240
72hair follicle morphogenesis (GO:0031069)3.15195057
73positive thymic T cell selection (GO:0045059)3.15131998
74long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.07405290
75positive regulation of transforming growth factor beta production (GO:0071636)3.05989692
76G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.04878011
77gap junction assembly (GO:0016264)3.02580563
78regulation of p38MAPK cascade (GO:1900744)3.01031789
79* keratinization (GO:0031424)21.2273860
80negative regulation of stress fiber assembly (GO:0051497)2.98116472
81atrioventricular valve morphogenesis (GO:0003181)2.97049986
82regulation of axon regeneration (GO:0048679)2.96617007
83regulation of neuron projection regeneration (GO:0070570)2.96617007
84cell-substrate junction assembly (GO:0007044)2.96250815
85cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.95459729
86response to fungus (GO:0009620)2.95384037
87sphingosine metabolic process (GO:0006670)2.93019542
88positive regulation of meiotic cell cycle (GO:0051446)2.92384953
89primary alcohol catabolic process (GO:0034310)2.92074402
90tooth mineralization (GO:0034505)2.91161980
91regulation of epidermis development (GO:0045682)2.90591418
92detection of bacterium (GO:0016045)2.89231726
93mitotic nuclear envelope reassembly (GO:0007084)2.88229750
94nuclear envelope reassembly (GO:0031468)2.88229750
95negative regulation of cAMP-mediated signaling (GO:0043951)2.87121035
96phospholipid scrambling (GO:0017121)2.86627984
97sphingoid metabolic process (GO:0046519)2.78814489
98adhesion of symbiont to host cell (GO:0044650)2.78023341
99virion attachment to host cell (GO:0019062)2.78023341
100negative regulation of keratinocyte proliferation (GO:0010839)2.77859972
101negative regulation of cardiac muscle hypertrophy (GO:0010614)2.75502111
102regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.75386241
103positive regulation of hair cycle (GO:0042635)2.74646392
104positive regulation of hair follicle development (GO:0051798)2.74646392
105actin-myosin filament sliding (GO:0033275)2.73890056
106muscle filament sliding (GO:0030049)2.73890056
107regulation of keratinocyte differentiation (GO:0045616)2.73691975
108regulation of epidermal cell differentiation (GO:0045604)2.73644956
109regulation of cardioblast differentiation (GO:0051890)2.72285497
110purinergic nucleotide receptor signaling pathway (GO:0035590)2.69474378
111retinol metabolic process (GO:0042572)2.67825795
112phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.67602272
113epithelium development (GO:0060429)2.63653191
114regulation of T-helper 1 type immune response (GO:0002825)2.62799907
115regulation of cholesterol efflux (GO:0010874)2.62367639
116hair cell differentiation (GO:0035315)2.61944626
117positive regulation of epidermis development (GO:0045684)2.60787953
118positive T cell selection (GO:0043368)2.60764518
119fatty-acyl-CoA metabolic process (GO:0035337)2.60754909
120phospholipid catabolic process (GO:0009395)2.59294570
121ventricular cardiac muscle cell action potential (GO:0086005)2.59251395
122diol metabolic process (GO:0034311)2.58946264
123positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.57495961
124long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.56816549
125phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.56324023
126negative regulation of cell fate commitment (GO:0010454)2.54711496
127negative regulation of T cell mediated immunity (GO:0002710)2.53915859
128detection of external biotic stimulus (GO:0098581)2.53456389
129sphingolipid biosynthetic process (GO:0030148)2.53090018
130adhesion of symbiont to host (GO:0044406)2.50602344
131regulation of keratinocyte proliferation (GO:0010837)2.50258176
132antibacterial humoral response (GO:0019731)2.49726637
133alditol phosphate metabolic process (GO:0052646)2.49394292
134T cell selection (GO:0045058)2.47342583
135regulation of skeletal muscle contraction (GO:0014819)2.47087161
136regulation of protein localization to cell surface (GO:2000008)2.46674652
137activation of MAPKKK activity (GO:0000185)2.45357340
138fatty-acyl-CoA biosynthetic process (GO:0046949)2.44224321
139negative regulation of lipase activity (GO:0060192)2.44177714
140cytoskeletal anchoring at plasma membrane (GO:0007016)2.44026268
141dendritic cell migration (GO:0036336)2.44025875
142regulation of cholesterol homeostasis (GO:2000188)2.43533677
143regulation of T cell receptor signaling pathway (GO:0050856)2.42429542
144positive regulation of response to biotic stimulus (GO:0002833)2.41189274
145cellular response to arsenic-containing substance (GO:0071243)2.39763224
146detection of other organism (GO:0098543)2.38753982
147epithelial cell-cell adhesion (GO:0090136)2.38437211
148epithelial cell proliferation (GO:0050673)2.37216395
149phosphatidylserine metabolic process (GO:0006658)2.37065419
150ethanol metabolic process (GO:0006067)2.36865389
151regulation of hair cycle (GO:0042634)2.35893066
152positive regulation of microtubule polymerization (GO:0031116)2.33903590
153dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.32927760
154nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.32843405
155actin-mediated cell contraction (GO:0070252)2.32833234
156negative regulation of acute inflammatory response (GO:0002674)2.32565656
157regulation of hair follicle development (GO:0051797)2.31642313
158amino sugar catabolic process (GO:0046348)2.28285918
159intestinal epithelial cell development (GO:0060576)2.27452861
160epithelial cell differentiation (GO:0030855)2.27006128
161establishment of skin barrier (GO:0061436)15.3986101
162desmosome organization (GO:0002934)13.8114321
163regulation of water loss via skin (GO:0033561)13.3869347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.60694782
2* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.26167851
3ESR1_21235772_ChIP-Seq_MCF-7_Human2.36554014
4ESR2_21235772_ChIP-Seq_MCF-7_Human2.29771928
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.26230302
6ZNF263_19887448_ChIP-Seq_K562_Human2.25617797
7SOX9_24532713_ChIP-Seq_HFSC_Mouse2.23964156
8TP63_17297297_ChIP-ChIP_HaCaT_Human14.1324463
9ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.93130507
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.86739076
11SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.82435452
12SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.82435452
13FOXO3_23340844_ChIP-Seq_DLD1_Human1.82260460
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78688399
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.75466993
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54352164
17VDR_22108803_ChIP-Seq_LS180_Human1.53236856
18HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53189167
19RXR_22108803_ChIP-Seq_LS180_Human1.52586981
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.49188398
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48400373
22ATF3_27146783_Chip-Seq_COLON_Human1.48241556
23* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.42532606
24* TP63_23658742_ChIP-Seq_EP156T_Human1.42367444
25GATA6_21074721_ChIP-Seq_CACO-2_Human1.41778189
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41687022
27* CTCF_27219007_Chip-Seq_Bcells_Human1.40240902
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40040014
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39532825
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37781994
31RUNX1_27514584_Chip-Seq_MCF-7_Human1.36289834
32* TP63_22573176_ChIP-Seq_HFKS_Human1.35419990
33RACK7_27058665_Chip-Seq_MCF-7_Human1.34474849
34KLF5_25053715_ChIP-Seq_YYC3_Human1.32729962
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29700545
36SOX2_20726797_ChIP-Seq_SW620_Human1.26265532
37* ERG_20517297_ChIP-Seq_VCAP_Human1.24406835
38AR_21572438_ChIP-Seq_LNCaP_Human1.23869263
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22637460
40BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.21112553
41GATA3_24758297_ChIP-Seq_MCF-7_Human1.20680222
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19531327
43ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17850342
44CEBPB_22108803_ChIP-Seq_LS180_Human1.15414710
45LXR_22292898_ChIP-Seq_THP-1_Human1.14684750
46UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14052916
47FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13993249
48* CTCF_20526341_ChIP-Seq_ESCs_Human1.13840950
49CJUN_26792858_Chip-Seq_BT549_Human1.13733157
50BCOR_27268052_Chip-Seq_Bcells_Human1.13635528
51AHR_22903824_ChIP-Seq_MCF-7_Human1.12579002
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11494169
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09346958
54TP53_16413492_ChIP-PET_HCT116_Human1.08218597
55BCAT_22108803_ChIP-Seq_LS180_Human1.07205400
56TP53_20018659_ChIP-ChIP_R1E_Mouse1.06525769
57EGR1_19032775_ChIP-ChIP_M12_Human1.04920073
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03750473
59P53_21459846_ChIP-Seq_SAOS-2_Human1.03250530
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02487688
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02409628
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02041314
63CLOCK_20551151_ChIP-Seq_293T_Human1.01611343
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99529201
65GATA3_21867929_ChIP-Seq_TH1_Mouse0.99360681
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98875492
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98675817
68AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98590315
69JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98101171
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97926042
71UBF1/2_26484160_Chip-Seq_HMECs_Human0.97101673
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95944949
73ERG_21242973_ChIP-ChIP_JURKAT_Human0.95238881
74NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94948832
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94948832
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94574071
77JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92036306
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91519455
79ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91135851
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89092158
81SA1_27219007_Chip-Seq_ERYTHROID_Human0.88967921
82TP53_18474530_ChIP-ChIP_U2OS_Human0.88374972
83EZH2_27294783_Chip-Seq_ESCs_Mouse0.88094043
84PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84580801
85JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84137288
86* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.83997514
87TAF2_19829295_ChIP-Seq_ESCs_Human0.83556864
88EZH2_27304074_Chip-Seq_ESCs_Mouse0.82933932
89CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.82219216
90TCF4_18268006_ChIP-ChIP_LS174T_Human0.81582785
91PPARA_22158963_ChIP-Seq_LIVER_Mouse0.81297029
92TCF4_22108803_ChIP-Seq_LS180_Human0.81250491
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80766248
94YY1_22570637_ChIP-Seq_MALME-3M_Human0.80392476
95GATA4_25053715_ChIP-Seq_YYC3_Human0.80146502
96GATA6_25053715_ChIP-Seq_YYC3_Human0.79703042
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.79300173
98OCT1_27270436_Chip-Seq_PROSTATE_Human0.78749966
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78653253
100MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.78196841
101P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78167874
102SMAD4_21741376_ChIP-Seq_ESCs_Human0.77095032
103ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76790259
104JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.76270472
105FOXM1_26456572_ChIP-Seq_MCF-7_Human0.76161900
106RNF2_27304074_Chip-Seq_ESCs_Mouse0.76143224
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.75915223
108CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75164401
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.75155116
110KDM2B_26808549_Chip-Seq_K562_Human0.74816726
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.74630696
112SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.73846380
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73786197
114E2F1_20622854_ChIP-Seq_HELA_Human0.73487278
115FOXH1_21741376_ChIP-Seq_ESCs_Human0.73296576
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.72800262
117RBPJ_21746931_ChIP-Seq_IB4_Human0.72165089
118SMC4_20622854_ChIP-Seq_HELA_Human0.71489557
119ELF1_20517297_ChIP-Seq_JURKAT_Human0.71354238
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.71054630
121SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.69822040
122HNFA_21074721_ChIP-Seq_CACO-2_Human0.69784928
123STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.69774447
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.68947365
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68485665
126FOXA1_25552417_ChIP-Seq_VCAP_Human0.65859869
127GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.65786909
128FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.61761139
129SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.61490256
130TBL1_22424771_ChIP-Seq_293T_Human0.58519759
131EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.58150063

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.61542424
2MP0005275_abnormal_skin_tensile7.80195232
3MP0005501_abnormal_skin_physiology5.15823005
4MP0000579_abnormal_nail_morphology4.09750401
5MP0010234_abnormal_vibrissa_follicle4.00011557
6MP0009379_abnormal_foot_pigmentation3.94807171
7MP0002060_abnormal_skin_morphology3.74520716
8MP0002254_reproductive_system_inflammat3.47948207
9MP0001216_abnormal_epidermal_layer3.45622611
10MP0004381_abnormal_hair_follicle3.39262413
11MP0010771_integument_phenotype3.26855114
12MP0004947_skin_inflammation3.26544679
13MP0003941_abnormal_skin_development3.24457903
14MP0002098_abnormal_vibrissa_morphology3.17156807
15MP0000647_abnormal_sebaceous_gland3.14684519
16MP0003705_abnormal_hypodermis_morpholog3.11502638
17MP0000383_abnormal_hair_follicle2.63527555
18MP0003453_abnormal_keratinocyte_physiol2.43272288
19MP0010678_abnormal_skin_adnexa2.36878534
20MP0005451_abnormal_body_composition2.23941073
21MP0000467_abnormal_esophagus_morphology2.20112910
22MP0000377_abnormal_hair_follicle2.17992010
23MP0000427_abnormal_hair_cycle1.97269315
24MP0002009_preneoplasia1.91897284
25MP0009931_abnormal_skin_appearance1.89201877
26MP0001188_hyperpigmentation1.86414634
27MP0001243_abnormal_dermal_layer1.82845921
28MP0000762_abnormal_tongue_morphology1.77313422
29MP0001851_eye_inflammation1.71840685
30MP0001191_abnormal_skin_condition1.64637352
31MP0001346_abnormal_lacrimal_gland1.61882808
32MP0000367_abnormal_coat/_hair1.58053708
33MP0000015_abnormal_ear_pigmentation1.40445957
34MP0004185_abnormal_adipocyte_glucose1.39092477
35MP0005174_abnormal_tail_pigmentation1.34250446
36MP0003566_abnormal_cell_adhesion1.30343535
37MP0002234_abnormal_pharynx_morphology1.20309683
38MP0004885_abnormal_endolymph1.19094902
39MP0003878_abnormal_ear_physiology1.17757757
40MP0005377_hearing/vestibular/ear_phenot1.17757757
41MP0002163_abnormal_gland_morphology1.13164453
42MP0002877_abnormal_melanocyte_morpholog1.11877785
43MP0002006_tumorigenesis1.11677431
44MP0003011_delayed_dark_adaptation1.04641172
45MP0000750_abnormal_muscle_regeneration1.00724389
46MP0000566_synostosis0.99886738
47MP0003763_abnormal_thymus_physiology0.96813024
48MP0002166_altered_tumor_susceptibility0.94951150
49MP0003136_yellow_coat_color0.94565955
50MP0001340_abnormal_eyelid_morphology0.91630702
51MP0003191_abnormal_cellular_cholesterol0.81709364
52MP0005075_abnormal_melanosome_morpholog0.74949690
53MP0003315_abnormal_perineum_morphology0.72238321
54MP0002095_abnormal_skin_pigmentation0.67808540
55MP0009053_abnormal_anal_canal0.64416743
56MP0001784_abnormal_fluid_regulation0.64088362
57MP0005023_abnormal_wound_healing0.63961610
58MP0002177_abnormal_outer_ear0.63616812
59MP0005409_darkened_coat_color0.59784011
60MP0000627_abnormal_mammary_gland0.58342648
61MP0003300_gastrointestinal_ulcer0.54821478
62MP0001849_ear_inflammation0.53538866
63MP0008438_abnormal_cutaneous_collagen0.51991498
64MP0000465_gastrointestinal_hemorrhage0.51449702
65MP0005379_endocrine/exocrine_gland_phen0.51089986
66MP0003755_abnormal_palate_morphology0.50622113
67MP0000372_irregular_coat_pigmentation0.47494791
68MP0005076_abnormal_cell_differentiation0.45354779
69MP0001984_abnormal_olfaction0.44290270
70MP0000751_myopathy0.44286169
71MP0001177_atelectasis0.44063628
72MP0008004_abnormal_stomach_pH0.43764246
73MP0003448_altered_tumor_morphology0.43540491
74MP0010030_abnormal_orbit_morphology0.43288717
75MP0005666_abnormal_adipose_tissue0.39766422
76MP0004264_abnormal_extraembryonic_tissu0.38764007
77MP0000759_abnormal_skeletal_muscle0.35611876
78MP0002111_abnormal_tail_morphology0.35391888
79MP0001348_abnormal_lacrimal_gland0.34971575
80MP0004782_abnormal_surfactant_physiolog0.34426582
81MP0000749_muscle_degeneration0.33924143
82MP0005503_abnormal_tendon_morphology0.33742188
83MP0002106_abnormal_muscle_physiology0.33407376
84MP0002971_abnormal_brown_adipose0.32715783
85MP0004087_abnormal_muscle_fiber0.31774387
86MP0000537_abnormal_urethra_morphology0.31759999
87MP0000470_abnormal_stomach_morphology0.31325036
88MP0005187_abnormal_penis_morphology0.31239412
89MP0009333_abnormal_splenocyte_physiolog0.31186027
90MP0003329_amyloid_beta_deposits0.30921630
91MP0000613_abnormal_salivary_gland0.30473091
92MP0004484_altered_response_of0.30445815
93MP0000747_muscle_weakness0.29891273
94MP0005620_abnormal_muscle_contractility0.29615893
95MP0002133_abnormal_respiratory_system0.29401851
96MP0005388_respiratory_system_phenotype0.29401851
97MP0004130_abnormal_muscle_cell0.28974021
98MP0001502_abnormal_circadian_rhythm0.28921393
99MP0010352_gastrointestinal_tract_polyps0.28808241
100MP0004272_abnormal_basement_membrane0.28515025
101MP0005171_absent_coat_pigmentation0.28375856
102MP0004019_abnormal_vitamin_homeostasis0.28248030
103MP0002148_abnormal_hypersensitivity_rea0.27430700
104MP0008961_abnormal_basal_metabolism0.26456479
105MP0003638_abnormal_response/metabolism_0.25722261
106MP0009672_abnormal_birth_weight0.24404986
107MP0001270_distended_abdomen0.23684113
108MP0000538_abnormal_urinary_bladder0.23658350
109MP0002697_abnormal_eye_size0.23408335
110MP0005508_abnormal_skeleton_morphology0.23190301
111MP0005369_muscle_phenotype0.22536675
112MP0009780_abnormal_chondrocyte_physiolo0.22322272
113MP0004197_abnormal_fetal_growth/weight/0.20847562
114MP0000432_abnormal_head_morphology0.20833967
115MP0002972_abnormal_cardiac_muscle0.20800595
116MP0003221_abnormal_cardiomyocyte_apopto0.20555500
117MP0001186_pigmentation_phenotype0.19632284
118MP0003950_abnormal_plasma_membrane0.19621833
119MP0004883_abnormal_blood_vessel0.19092012
120MP0009384_cardiac_valve_regurgitation0.19010463
121MP0002282_abnormal_trachea_morphology0.18973862
122MP0003828_pulmonary_edema0.18899766
123MP0008789_abnormal_olfactory_epithelium0.18056286
124MP0005375_adipose_tissue_phenotype0.17706664
125MP0001299_abnormal_eye_distance/0.16252597
126MP0005248_abnormal_Harderian_gland0.16216309
127MP0005647_abnormal_sex_gland0.15589993
128MP0000428_abnormal_craniofacial_morphol0.13500709
129MP0001756_abnormal_urination0.13136237
130MP0003656_abnormal_erythrocyte_physiolo0.13061715
131MP0002233_abnormal_nose_morphology0.12244184
132MP0005394_taste/olfaction_phenotype0.12142153
133MP0005499_abnormal_olfactory_system0.12142153
134MP0002138_abnormal_hepatobiliary_system0.10677902
135MP0000569_abnormal_digit_pigmentation0.10086109
136MP0005193_abnormal_anterior_eye0.09506301
137MP0002136_abnormal_kidney_physiology0.08718670
138MP0004043_abnormal_pH_regulation0.08060571

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)8.56527919
2Hypotrichosis (HP:0001006)8.38546474
3Conjunctival hamartoma (HP:0100780)7.71827444
4Palmoplantar hyperkeratosis (HP:0000972)7.28329011
5Plantar hyperkeratosis (HP:0007556)7.14304249
6Palmar hyperkeratosis (HP:0010765)6.86027360
7Erythema (HP:0010783)6.13073811
8Erythroderma (HP:0001019)6.05393497
9Woolly hair (HP:0002224)5.94277313
10Right ventricular cardiomyopathy (HP:0011663)5.91711411
11Onycholysis (HP:0001806)5.85072160
12Abnormality of nail color (HP:0100643)5.72041560
13Fragile nails (HP:0001808)5.09889581
14Congenital ichthyosiform erythroderma (HP:0007431)5.07167912
15Thick nail (HP:0001805)4.95468216
16Hamartoma of the eye (HP:0010568)4.79715295
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.58185167
18Pili torti (HP:0003777)4.55295604
19Gangrene (HP:0100758)4.43092953
20Abnormal blistering of the skin (HP:0008066)4.36123697
21Autoimmune hemolytic anemia (HP:0001890)4.35831631
22Milia (HP:0001056)4.33980799
23Nail dystrophy (HP:0008404)3.78525031
24Parakeratosis (HP:0001036)3.63239036
25Corneal erosion (HP:0200020)3.47894300
26Areflexia of lower limbs (HP:0002522)3.42006335
27Hyporeflexia of lower limbs (HP:0002600)3.41140660
28Palmoplantar keratoderma (HP:0000982)3.40762912
29Ventricular tachycardia (HP:0004756)3.26393720
30Round ear (HP:0100830)3.12122163
31Absent eyelashes (HP:0000561)3.08123286
32Sparse eyelashes (HP:0000653)3.05815099
33Hypohidrosis (HP:0000966)3.05496461
34Curly hair (HP:0002212)2.98836853
35Alopecia of scalp (HP:0002293)2.97962379
36Ectropion (HP:0000656)2.97505483
37Ridged nail (HP:0001807)2.92813917
38Distal lower limb muscle weakness (HP:0009053)2.89449510
39Abnormal hair laboratory examination (HP:0003328)2.89418480
40Lip pit (HP:0100267)2.87500440
41Distal arthrogryposis (HP:0005684)2.86088979
42Hypergammaglobulinemia (HP:0010702)2.83239316
43Stomatitis (HP:0010280)2.82474586
44Pruritus (HP:0000989)2.76654330
45Achilles tendon contracture (HP:0001771)2.71088575
46Type 1 muscle fiber predominance (HP:0003803)2.67923614
47Muscle fiber inclusion bodies (HP:0100299)2.66924026
48Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.64803813
49Increased connective tissue (HP:0009025)2.63749682
50Nemaline bodies (HP:0003798)2.62098805
51Oligodontia (HP:0000677)2.55529031
52Absent hair (HP:0002298)2.55003724
53Atrophic scars (HP:0001075)2.52362646
54Abnormality of the Achilles tendon (HP:0005109)2.51694375
55Oral leukoplakia (HP:0002745)2.50546708
56Concave nail (HP:0001598)2.48121765
57Advanced eruption of teeth (HP:0006288)2.45621391
58Pustule (HP:0200039)2.44628472
59Hypoplastic labia majora (HP:0000059)2.28628024
60Acanthosis nigricans (HP:0000956)2.28343050
61Ulnar deviation of the wrist (HP:0003049)2.23110091
62Natal tooth (HP:0000695)2.23003348
63Furrowed tongue (HP:0000221)2.22319882
64Muscle fiber splitting (HP:0003555)2.20596529
65Laryngomalacia (HP:0001601)2.19078926
66Brittle hair (HP:0002299)2.18388947
67Dehydration (HP:0001944)2.17826996
68Abnormality of the axillary hair (HP:0100134)2.17331949
69Abnormality of secondary sexual hair (HP:0009888)2.17331949
70Fatigable weakness (HP:0003473)2.16471190
71Abnormality of the neuromuscular junction (HP:0003398)2.16471190
72Hamartoma (HP:0010566)2.15794514
73Abnormal pupillary function (HP:0007686)2.13559767
74Calcaneovalgus deformity (HP:0001848)2.12862387
75Exercise-induced myalgia (HP:0003738)2.12665757
76Myopathic facies (HP:0002058)2.08146407
77Abnormality of the labia majora (HP:0012881)2.07661956
78Abnormality of hair growth rate (HP:0011363)2.07516508
79Slow-growing hair (HP:0002217)2.07516508
80Selective tooth agenesis (HP:0001592)2.06731132
81Melanocytic nevus (HP:0000995)1.98846228
82Hyperhidrosis (HP:0000975)1.98158633
83Blepharitis (HP:0000498)1.95547649
84Split foot (HP:0001839)1.94666230
85Eczematoid dermatitis (HP:0000976)1.94636657
86Neck muscle weakness (HP:0000467)1.93839843
87Follicular hyperkeratosis (HP:0007502)1.92852617
88Sudden death (HP:0001699)1.91333785
89Dry skin (HP:0000958)1.89745423
90Lack of skin elasticity (HP:0100679)1.89453185
91Conical tooth (HP:0000698)1.87597383
92Depressed nasal tip (HP:0000437)1.87365487
93Deformed tarsal bones (HP:0008119)1.85510337
94Duplicated collecting system (HP:0000081)1.84928463
95Sparse scalp hair (HP:0002209)1.83704671
96Dry hair (HP:0011359)1.81337576
97Aplasia cutis congenita (HP:0001057)1.79835694
98Corneal dystrophy (HP:0001131)1.78635901
99Absent phalangeal crease (HP:0006109)1.78270909
100Verrucae (HP:0200043)1.77179690
101Papilloma (HP:0012740)1.77179690
102Skin ulcer (HP:0200042)1.75264820
103Abnormality of the salivary glands (HP:0010286)1.73383653
104Septate vagina (HP:0001153)1.72638453
105Nasolacrimal duct obstruction (HP:0000579)1.71964745
106Ventricular fibrillation (HP:0001663)1.70677032
107Abnormality of permanent molar morphology (HP:0011071)1.69534221
108Abnormality of the dental root (HP:0006486)1.69534221
109Taurodontia (HP:0000679)1.69534221
110Malignant hyperthermia (HP:0002047)1.67101679
111Xerostomia (HP:0000217)1.66878681
112Urticaria (HP:0001025)1.65304511
113Fragile skin (HP:0001030)1.65026050
114Alveolar cell carcinoma (HP:0006519)1.63379690
115Sepsis (HP:0100806)1.61606827
116Abnormality of the distal phalanges of the toes (HP:0010182)1.59718441
117Abnormality of molar (HP:0011077)1.58402152
118Abnormality of molar morphology (HP:0011070)1.58402152
119Exercise-induced muscle cramps (HP:0003710)1.56807811
120Abnormality of the renal collecting system (HP:0004742)1.56665839
121Abnormality of the gastric mucosa (HP:0004295)1.56591127
122Amelogenesis imperfecta (HP:0000705)1.56388552
123Villous atrophy (HP:0011473)1.54088373
124Abnormality of small intestinal villus morphology (HP:0011472)1.54088373
125Aplasia involving bones of the extremities (HP:0009825)1.52488576
126Aplasia involving bones of the upper limbs (HP:0009823)1.52488576
127Aplasia of the phalanges of the hand (HP:0009802)1.52488576
128Fine hair (HP:0002213)1.51389765
129Carious teeth (HP:0000670)1.50012724
130Abnormality of the dental pulp (HP:0006479)1.49643191
131Autoamputation (HP:0001218)1.48900334
132Keratoconjunctivitis sicca (HP:0001097)1.48438727
133Difficulty running (HP:0009046)1.47737727
134Popliteal pterygium (HP:0009756)1.46787472
135Paralysis (HP:0003470)1.46715284
136Anonychia (HP:0001798)1.45162587
137Neoplasm of the tracheobronchial system (HP:0100552)1.42621144
138Hypodontia (HP:0000668)1.41676090
139Abnormality of the fingernails (HP:0001231)1.41268074
140Anhidrosis (HP:0000970)1.38365701
141Abnormality of placental membranes (HP:0011409)1.35680522
142Amniotic constriction ring (HP:0009775)1.35680522
143Abnormality of the lacrimal duct (HP:0011481)1.35120927
144Breast hypoplasia (HP:0003187)1.34961703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK35.23080264
2TGFBR14.55494063
3RIPK14.12783215
4MAP3K33.94574961
5FER3.89933286
6BCR3.38570550
7BRD43.15974233
8MST1R3.03047045
9TTN2.91059372
10MST42.79084209
11MAP3K62.67456604
12TAOK12.47310564
13PIK3CG2.42716062
14EEF2K2.19438164
15RPS6KB22.11971055
16MAP3K112.10725135
17DYRK1B2.08061590
18MAP3K22.03506600
19MAP2K32.01410116
20ERN11.90451548
21OBSCN1.90079611
22SGK4941.90020014
23SGK2231.90020014
24DAPK21.79051381
25EPHA21.62054457
26IRAK11.58647137
27FGFR11.58096368
28EPHB21.53963713
29WNK11.50010128
30ABL21.48003297
31CDK61.47266517
32AKT31.41164390
33TRPM71.38865964
34IRAK21.36781380
35MAPKAPK51.33630073
36TGFBR21.32326097
37MAP2K61.28807732
38STK38L1.28408610
39CDK41.22137647
40MAP3K11.21892668
41LRRK21.20576180
42STK31.19720647
43SGK21.19122454
44IKBKB1.12863886
45IRAK41.07093315
46TAOK21.04482603
47PRPF4B1.02355608
48ADRBK11.01679900
49NME11.01397296
50MAP3K71.00281720
51NTRK20.99432391
52DYRK30.97419816
53MAP3K120.96475171
54SGK30.91651288
55LATS10.90867646
56FGFR20.87889408
57MOS0.85305807
58PHKG20.85009898
59PHKG10.85009898
60GRK70.84291802
61MAPK150.83604326
62PKN10.80582904
63GSK3A0.79727923
64MAPKAPK20.79117178
65PDGFRB0.78189842
66MAP3K90.75481178
67MARK20.75378745
68MET0.71848091
69MTOR0.71688233
70STK100.70378260
71PTK60.66939434
72TBK10.66735392
73CAMK2G0.66377184
74ERBB30.65931800
75DMPK0.65704663
76CDK120.65164752
77BMX0.64855087
78BLK0.64352319
79ITK0.61737464
80TRIB30.61317377
81PRKCI0.61048291
82RIPK40.60633495
83HCK0.59305600
84DDR20.59226370
85MAP2K40.58447955
86CDK90.58093027
87MAP3K140.56776612
88PAK30.53377808
89STK240.52213951
90CAMK2D0.49485640
91EPHA30.48764231
92FGFR40.48528692
93RPS6KB10.48528329
94FGFR30.46857214
95DYRK20.45842545
96NLK0.45763642
97FYN0.45570948
98EPHB10.45493760
99PRKCE0.45421414
100MAPK120.44631214
101PIM20.44081677
102MAPK40.44039725
103TIE10.43561538
104TNK20.43249888
105SGK10.42319551
106GRK60.41058922
107MAP4K10.38970681
108CHUK0.36711239
109ABL10.35367651
110NEK60.35036240
111PRKD10.34780400
112AURKA0.34036238
113LATS20.33428304
114PAK20.32889115
115ILK0.31758488
116MAP2K10.29961092
117PDK20.28184996
118ICK0.27221426
119TAF10.26564518
120MAPK70.25460777
121CDK30.25403477
122PRKD20.25229698
123TYRO30.25082972
124PRKCH0.23860215
125TYK20.23230916
126HIPK20.23002222
127PDGFRA0.22935213
128PRKACA0.22852307
129MAP2K20.22631517
130TAOK30.22606097
131NEK10.21631398
132KIT0.21543346
133ROCK20.21515068
134PRKAA20.21472163
135SRC0.20926423
136CSNK1A10.20891595
137IKBKE0.20486514
138FRK0.20466631
139AURKB0.20277571
140IGF1R0.19443965
141PTK20.19407863
142MAPK90.18840554
143ERBB40.18779556
144PRKCB0.17837294
145MAP3K50.17264843
146GRK50.16074375
147MAPK80.15921429
148STK380.14757630

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.05146800
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.01849186
3Linoleic acid metabolism_Homo sapiens_hsa005912.99035585
4Fatty acid elongation_Homo sapiens_hsa000622.57245115
5Sulfur metabolism_Homo sapiens_hsa009202.52505561
6Bladder cancer_Homo sapiens_hsa052192.45794241
7Phenylalanine metabolism_Homo sapiens_hsa003602.18819697
8Staphylococcus aureus infection_Homo sapiens_hsa051502.14502995
9Circadian rhythm_Homo sapiens_hsa047102.07064713
10Arachidonic acid metabolism_Homo sapiens_hsa005902.04998447
11Ovarian steroidogenesis_Homo sapiens_hsa049131.91271731
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.86863684
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.86847242
14Histidine metabolism_Homo sapiens_hsa003401.84384976
15Ether lipid metabolism_Homo sapiens_hsa005651.82401553
16Fat digestion and absorption_Homo sapiens_hsa049751.62663877
17Renin secretion_Homo sapiens_hsa049241.62102338
18Sphingolipid metabolism_Homo sapiens_hsa006001.60720791
19Steroid biosynthesis_Homo sapiens_hsa001001.53384387
20Non-small cell lung cancer_Homo sapiens_hsa052231.46756042
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46070594
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46022821
23Dorso-ventral axis formation_Homo sapiens_hsa043201.36258526
24GnRH signaling pathway_Homo sapiens_hsa049121.33600392
25VEGF signaling pathway_Homo sapiens_hsa043701.32369916
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.31097269
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21963418
28Retinol metabolism_Homo sapiens_hsa008301.19020661
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17834748
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17185005
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13511533
32Choline metabolism in cancer_Homo sapiens_hsa052311.11968454
33Tight junction_Homo sapiens_hsa045301.07957418
34Tyrosine metabolism_Homo sapiens_hsa003501.04783621
35Adherens junction_Homo sapiens_hsa045200.99216833
36Proteoglycans in cancer_Homo sapiens_hsa052050.98342881
37Oxytocin signaling pathway_Homo sapiens_hsa049210.98150267
38Platelet activation_Homo sapiens_hsa046110.98110140
39Olfactory transduction_Homo sapiens_hsa047400.95392376
40Long-term depression_Homo sapiens_hsa047300.94373413
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93285802
42ECM-receptor interaction_Homo sapiens_hsa045120.92380691
43Axon guidance_Homo sapiens_hsa043600.92319605
44Primary immunodeficiency_Homo sapiens_hsa053400.91036517
45Basal cell carcinoma_Homo sapiens_hsa052170.90560589
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90060749
47Chemical carcinogenesis_Homo sapiens_hsa052040.89438946
48T cell receptor signaling pathway_Homo sapiens_hsa046600.88799198
49Gastric acid secretion_Homo sapiens_hsa049710.86975007
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.85816472
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84859306
52Amoebiasis_Homo sapiens_hsa051460.83344188
53Pancreatic secretion_Homo sapiens_hsa049720.82354501
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82119726
55Inositol phosphate metabolism_Homo sapiens_hsa005620.80952999
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79619210
57Melanogenesis_Homo sapiens_hsa049160.78921456
58Dilated cardiomyopathy_Homo sapiens_hsa054140.78595208
59Ras signaling pathway_Homo sapiens_hsa040140.76794550
60PPAR signaling pathway_Homo sapiens_hsa033200.75860268
61Hippo signaling pathway_Homo sapiens_hsa043900.75689877
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74638700
63beta-Alanine metabolism_Homo sapiens_hsa004100.73501576
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73339729
65Endocytosis_Homo sapiens_hsa041440.72584292
66Calcium signaling pathway_Homo sapiens_hsa040200.72201591
67Ribosome_Homo sapiens_hsa030100.69928210
68Salivary secretion_Homo sapiens_hsa049700.69496045
69Vitamin digestion and absorption_Homo sapiens_hsa049770.68565717
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68269623
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68247005
72Fatty acid biosynthesis_Homo sapiens_hsa000610.67959278
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.67786937
74Glioma_Homo sapiens_hsa052140.67338796
75MAPK signaling pathway_Homo sapiens_hsa040100.65957156
76Collecting duct acid secretion_Homo sapiens_hsa049660.64344785
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63752469
78Serotonergic synapse_Homo sapiens_hsa047260.63560270
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62828715
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.62464921
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.62292508
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.62234529
83Glutamatergic synapse_Homo sapiens_hsa047240.61665525
84Insulin resistance_Homo sapiens_hsa049310.60043533
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.60009640
86ErbB signaling pathway_Homo sapiens_hsa040120.59568090
87Long-term potentiation_Homo sapiens_hsa047200.58384157
88ABC transporters_Homo sapiens_hsa020100.58220959
89Hematopoietic cell lineage_Homo sapiens_hsa046400.57859933
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.56170528
91Hepatitis C_Homo sapiens_hsa051600.54640539
92Phototransduction_Homo sapiens_hsa047440.53979660
93Fatty acid degradation_Homo sapiens_hsa000710.53548491
94MicroRNAs in cancer_Homo sapiens_hsa052060.52850780
95Toxoplasmosis_Homo sapiens_hsa051450.52808767
96Small cell lung cancer_Homo sapiens_hsa052220.51858162
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51501928
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51307871
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50815086
100Acute myeloid leukemia_Homo sapiens_hsa052210.50791412
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49897959
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49675144
103Pertussis_Homo sapiens_hsa051330.49254489
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48494772
105FoxO signaling pathway_Homo sapiens_hsa040680.47064230
106Tuberculosis_Homo sapiens_hsa051520.45686024
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45077175
108Renal cell carcinoma_Homo sapiens_hsa052110.44405655
109Protein digestion and absorption_Homo sapiens_hsa049740.43585804
110Fatty acid metabolism_Homo sapiens_hsa012120.43563691
111Graft-versus-host disease_Homo sapiens_hsa053320.43265472
112Osteoclast differentiation_Homo sapiens_hsa043800.43097629
113Thyroid cancer_Homo sapiens_hsa052160.42144557
114Hedgehog signaling pathway_Homo sapiens_hsa043400.41760012
115Amphetamine addiction_Homo sapiens_hsa050310.39741124
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37134960
117African trypanosomiasis_Homo sapiens_hsa051430.37078269
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37015016
119Nitrogen metabolism_Homo sapiens_hsa009100.36677380
120Notch signaling pathway_Homo sapiens_hsa043300.36279548
121Rap1 signaling pathway_Homo sapiens_hsa040150.35808403
122Salmonella infection_Homo sapiens_hsa051320.35510449
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35186685
124Circadian entrainment_Homo sapiens_hsa047130.34754085
125p53 signaling pathway_Homo sapiens_hsa041150.34709564
126Renin-angiotensin system_Homo sapiens_hsa046140.34064429
127Estrogen signaling pathway_Homo sapiens_hsa049150.33663364
128Caffeine metabolism_Homo sapiens_hsa002320.33480289
129Mineral absorption_Homo sapiens_hsa049780.32738429
130Glycerolipid metabolism_Homo sapiens_hsa005610.31514905
131Insulin signaling pathway_Homo sapiens_hsa049100.28821958
132TGF-beta signaling pathway_Homo sapiens_hsa043500.28646075
133Influenza A_Homo sapiens_hsa051640.27009326
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.24750191
135cAMP signaling pathway_Homo sapiens_hsa040240.23837378
136Pathways in cancer_Homo sapiens_hsa052000.22400352
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21490130

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