ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	peptide cross-linking (GO:0018149)	9.70976787
2	hemidesmosome assembly (GO:0031581)	9.41704774
3	keratinocyte differentiation (GO:0030216)	9.24100803
4	water homeostasis (GO:0030104)	8.74421056
5	epidermal cell differentiation (GO:0009913)	7.00110224
6	skin morphogenesis (GO:0043589)	6.69565532
7	long-chain fatty acid biosynthetic process (GO:0042759)	6.57187454
8	intermediate filament organization (GO:0045109)	6.51197402
9	bundle of His cell to Purkinje myocyte communication (GO:0086069)	6.35661975
10	epidermis development (GO:0008544)	6.02638904
11	fatty acid elongation (GO:0030497)	5.87625470
12	glucosamine-containing compound catabolic process (GO:1901072)	5.45374310
13	linoleic acid metabolic process (GO:0043651)	5.09525710
14	keratinocyte proliferation (GO:0043616)	5.05782304
15	keratinocyte development (GO:0003334)	4.28997309
16	ectoderm development (GO:0007398)	4.18594716
17	intermediate filament cytoskeleton organization (GO:0045104)	4.16157582
18	intermediate filament-based process (GO:0045103)	4.03173176
19	fibrinolysis (GO:0042730)	3.90670218
20	skin development (GO:0043588)	3.88931469
21	lipoxygenase pathway (GO:0019372)	3.87971270
22	regulation of ruffle assembly (GO:1900027)	3.78167037
23	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	3.65652280
24	actin-myosin filament sliding (GO:0033275)	3.56354579
25	muscle filament sliding (GO:0030049)	3.56354579
26	virion attachment to host cell (GO:0019062)	3.53596679
27	adhesion of symbiont to host cell (GO:0044650)	3.53596679
28	regulation of skeletal muscle contraction (GO:0014819)	3.44510231
29	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.37164527
30	negative regulation of cell fate specification (GO:0009996)	3.36492132
31	atrioventricular valve morphogenesis (GO:0003181)	3.29978633
32	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	3.24981612
33	cell-substrate junction assembly (GO:0007044)	3.22665846
34	fatty-acyl-CoA metabolic process (GO:0035337)	3.14488068
35	fatty-acyl-CoA biosynthetic process (GO:0046949)	3.14297589
36	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.04306564
37	skeletal muscle adaptation (GO:0043501)	3.01596551
38	adhesion of symbiont to host (GO:0044406)	3.01043411
39	* keratinization (GO:0031424)	22.8883362
40	sphingosine metabolic process (GO:0006670)	2.99618041
41	actin-mediated cell contraction (GO:0070252)	2.99283791
42	negative regulation of keratinocyte proliferation (GO:0010839)	2.97841978
43	primary alcohol catabolic process (GO:0034310)	2.97385718
44	plasma membrane repair (GO:0001778)	2.93235290
45	regulation of cardioblast differentiation (GO:0051890)	2.91806208
46	cell wall macromolecule metabolic process (GO:0044036)	2.84956286
47	cell wall macromolecule catabolic process (GO:0016998)	2.84956286
48	epithelium development (GO:0060429)	2.84448460
49	very long-chain fatty acid metabolic process (GO:0000038)	2.81777266
50	positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)	2.80538307
51	sphingoid metabolic process (GO:0046519)	2.77672928
52	ventricular cardiac muscle cell action potential (GO:0086005)	2.73988764
53	negative regulation of muscle hypertrophy (GO:0014741)	2.73983659
54	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	2.68437736
55	detection of bacterium (GO:0016045)	2.67772853
56	negative regulation of cell fate commitment (GO:0010454)	2.65391297
57	diol metabolic process (GO:0034311)	2.64160742
58	surfactant homeostasis (GO:0043129)	2.60093190
59	epithelial cell-cell adhesion (GO:0090136)	2.57581109
60	regulation of keratinocyte differentiation (GO:0045616)	2.55987988
61	phospholipid scrambling (GO:0017121)	2.54672198
62	skeletal muscle contraction (GO:0003009)	2.51910417
63	establishment of tissue polarity (GO:0007164)	2.48424748
64	establishment of planar polarity (GO:0001736)	2.48424748
65	tooth mineralization (GO:0034505)	2.47303889
66	actin filament-based movement (GO:0030048)	2.47091098
67	eyelid development in camera-type eye (GO:0061029)	2.47087493
68	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.46946144
69	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.46098078
70	thioester biosynthetic process (GO:0035384)	2.44894795
71	acyl-CoA biosynthetic process (GO:0071616)	2.44894795
72	myotube differentiation (GO:0014902)	2.43513063
73	negative regulation of stress fiber assembly (GO:0051497)	2.41903509
74	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.40732579
75	regulation of hypersensitivity (GO:0002883)	2.40469027
76	phospholipid efflux (GO:0033700)	2.39905108
77	retina homeostasis (GO:0001895)	2.39514456
78	hair follicle morphogenesis (GO:0031069)	2.38426188
79	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.36913628
80	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.35089870
81	ephrin receptor signaling pathway (GO:0048013)	2.34666605
82	chemical homeostasis within a tissue (GO:0048875)	2.32040726
83	positive regulation of monocyte chemotaxis (GO:0090026)	2.31269430
84	sarcoplasmic reticulum calcium ion transport (GO:0070296)	2.30295739
85	regulation of heart rate by cardiac conduction (GO:0086091)	2.30132290
86	positive regulation of epidermis development (GO:0045684)	2.29897718
87	regulation of skeletal muscle cell differentiation (GO:2001014)	2.28075223
88	hair cycle process (GO:0022405)	2.27910476
89	molting cycle process (GO:0022404)	2.27910476
90	gland morphogenesis (GO:0022612)	2.25271414
91	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.24705006
92	hair follicle development (GO:0001942)	2.23982752
93	skeletal muscle fiber development (GO:0048741)	2.23759749
94	cell communication involved in cardiac conduction (GO:0086065)	2.21722653
95	establishment of skin barrier (GO:0061436)	18.4941700
96	regulation of water loss via skin (GO:0033561)	15.9593721
97	desmosome organization (GO:0002934)	13.3829578
98	hair cycle (GO:0042633)	10.9285108
99	molting cycle (GO:0042303)	10.9285108
100	multicellular organismal water homeostasis (GO:0050891)	10.4923036

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.85837789
2	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.46393920
3	ZNF263_19887448_ChIP-Seq_K562_Human	2.52200020
4	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.49648920
5	SOX9_24532713_ChIP-Seq_HFSC_Mouse	2.31854689
6	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.08203484
7	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.01765722
8	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.01411049
9	TP63_17297297_ChIP-ChIP_HaCaT_Human	13.9407594
10	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.96209861
11	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.74015390
12	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.73215110
13	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.71783882
14	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.71783882
15	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.69769774
16	CTCF_27219007_Chip-Seq_Bcells_Human	1.63819881
17	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.57922028
18	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.51316631
19	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.50254978
20	TP63_22573176_ChIP-Seq_HFKS_Human	1.47676175
21	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.47145163
22	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.46628424
23	TP63_23658742_ChIP-Seq_EP156T_Human	1.46205514
24	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.45031894
25	CTCF_20526341_ChIP-Seq_ESCs_Human	1.43471192
26	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.43261766
27	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.41758502
28	RXR_22108803_ChIP-Seq_LS180_Human	1.36949699
29	RACK7_27058665_Chip-Seq_MCF-7_Human	1.36321859
30	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.27210268
31	* SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.27122833
32	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.25173744
33	ERG_20517297_ChIP-Seq_VCAP_Human	1.24537974
34	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.23501421
35	KLF5_25053715_ChIP-Seq_YYC3_Human	1.21899175
36	ATF3_27146783_Chip-Seq_COLON_Human	1.20389520
37	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.19668898
38	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.19398017
39	AR_21572438_ChIP-Seq_LNCaP_Human	1.19083641
40	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.18624754
41	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.18511014
42	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.18204921
43	CJUN_26792858_Chip-Seq_BT549_Human	1.16227072
44	BCOR_27268052_Chip-Seq_Bcells_Human	1.16044281
45	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.14629952
46	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.13291540
47	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.11801622
48	LXR_22292898_ChIP-Seq_THP-1_Human	1.11186908
49	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.10982257
50	CEBPB_22108803_ChIP-Seq_LS180_Human	1.07488593
51	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.07454675
52	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.06450506
53	SOX2_20726797_ChIP-Seq_SW620_Human	1.06444379
54	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.06004381
55	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.05159630
56	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.04901216
57	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.03453909
58	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.02986285
59	E2F1_20622854_ChIP-Seq_HELA_Human	1.02133973
60	TP53_18474530_ChIP-ChIP_U2OS_Human	1.01947633
61	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.96623905
62	EGR1_19032775_ChIP-ChIP_M12_Human	0.96220983
63	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.93368631
64	AHR_22903824_ChIP-Seq_MCF-7_Human	0.92182131
65	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.91925037
66	BCAT_22108803_ChIP-Seq_LS180_Human	0.91316411
67	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.88822376
68	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.88440358
69	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.87723335
70	P68_20966046_ChIP-Seq_HELA_Human	0.87233708
71	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.87199417
72	VDR_22108803_ChIP-Seq_LS180_Human	0.86848918
73	BCL6_27268052_Chip-Seq_Bcells_Human	0.86449573
74	TAF2_19829295_ChIP-Seq_ESCs_Human	0.86271368
75	NANOG_20526341_ChIP-Seq_ESCs_Human	0.86049938
76	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.85840083
77	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.85840083
78	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.85729144
79	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.85532805
80	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.84549225
81	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.83379888
82	KDM2B_26808549_Chip-Seq_K562_Human	0.82805892
83	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.81408235
84	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.81148367
85	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.80829196
86	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.80339809
87	TP53_16413492_ChIP-PET_HCT116_Human	0.77066310
88	RBPJ_21746931_ChIP-Seq_IB4_Human	0.76779644
89	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.76764012
90	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.75729442
91	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.75329051
92	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.74867317
93	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.74553291
94	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.74228463
95	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.74057308
96	* GATA3_21867929_ChIP-Seq_TH1_Mouse	0.74034790
97	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.73760253
98	SA1_27219007_Chip-Seq_Bcells_Human	0.73727980
99	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.73611533
100	GATA4_25053715_ChIP-Seq_YYC3_Human	0.71669320

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002796_impaired_skin_barrier	8.95839591
2	MP0005275_abnormal_skin_tensile	7.91261653
3	MP0005501_abnormal_skin_physiology	5.43677934
4	MP0000579_abnormal_nail_morphology	4.85287777
5	MP0010234_abnormal_vibrissa_follicle	3.71116231
6	MP0003705_abnormal_hypodermis_morpholog	3.52516989
7	MP0002060_abnormal_skin_morphology	3.51475588
8	MP0001216_abnormal_epidermal_layer	3.44527079
9	MP0002254_reproductive_system_inflammat	3.38350115
10	MP0004947_skin_inflammation	3.26668329
11	MP0010771_integument_phenotype	3.25996975
12	MP0003941_abnormal_skin_development	3.17248505
13	MP0000647_abnormal_sebaceous_gland	3.09052496
14	MP0000383_abnormal_hair_follicle	2.99932182
15	MP0001188_hyperpigmentation	2.80923352
16	MP0002098_abnormal_vibrissa_morphology	2.68089438
17	MP0004381_abnormal_hair_follicle	2.60398268
18	MP0010678_abnormal_skin_adnexa	2.55939955
19	MP0000427_abnormal_hair_cycle	2.40995746
20	MP0000467_abnormal_esophagus_morphology	2.29643143
21	MP0005451_abnormal_body_composition	2.22527795
22	MP0003453_abnormal_keratinocyte_physiol	2.21630908
23	MP0000377_abnormal_hair_follicle	2.17047102
24	MP0001243_abnormal_dermal_layer	1.92791407
25	MP0009931_abnormal_skin_appearance	1.88591598
26	MP0000762_abnormal_tongue_morphology	1.84410969
27	MP0001191_abnormal_skin_condition	1.64780155
28	MP0004185_abnormal_adipocyte_glucose	1.63534295
29	MP0002234_abnormal_pharynx_morphology	1.51689651
30	MP0003566_abnormal_cell_adhesion	1.43532065
31	MP0000367_abnormal_coat/_hair	1.42481820
32	MP0003191_abnormal_cellular_cholesterol	1.26027739
33	MP0001346_abnormal_lacrimal_gland	1.21107751
34	MP0002095_abnormal_skin_pigmentation	1.15941971
35	MP0000566_synostosis	1.12547455
36	MP0001851_eye_inflammation	1.10585406
37	MP0005409_darkened_coat_color	0.83891853
38	MP0000751_myopathy	0.81293620
39	MP0008438_abnormal_cutaneous_collagen	0.78997638
40	MP0010030_abnormal_orbit_morphology	0.78674663
41	MP0001340_abnormal_eyelid_morphology	0.78035152
42	MP0001784_abnormal_fluid_regulation	0.74401240
43	MP0002177_abnormal_outer_ear	0.74202464
44	MP0002009_preneoplasia	0.73377488
45	MP0000749_muscle_degeneration	0.70595124
46	MP0001849_ear_inflammation	0.64881664
47	MP0009053_abnormal_anal_canal	0.64440470
48	MP0000750_abnormal_muscle_regeneration	0.63687805
49	MP0004782_abnormal_surfactant_physiolog	0.62294704
50	MP0000465_gastrointestinal_hemorrhage	0.59825502
51	MP0005023_abnormal_wound_healing	0.58211377
52	MP0000747_muscle_weakness	0.53857594
53	MP0005666_abnormal_adipose_tissue	0.52579677
54	MP0002877_abnormal_melanocyte_morpholog	0.51357973
55	MP0009379_abnormal_foot_pigmentation	0.48651801
56	MP0003755_abnormal_palate_morphology	0.47785173
57	MP0000759_abnormal_skeletal_muscle	0.46252987
58	MP0003011_delayed_dark_adaptation	0.45886995
59	MP0000627_abnormal_mammary_gland	0.45675313
60	MP0002106_abnormal_muscle_physiology	0.44908398
61	MP0003763_abnormal_thymus_physiology	0.44146475
62	MP0009672_abnormal_birth_weight	0.43538978
63	MP0002006_tumorigenesis	0.41773231
64	MP0002166_altered_tumor_susceptibility	0.41457419
65	MP0002111_abnormal_tail_morphology	0.41163239
66	MP0004087_abnormal_muscle_fiber	0.38474445
67	MP0003385_abnormal_body_wall	0.37843060
68	MP0003315_abnormal_perineum_morphology	0.37530988
69	MP0000537_abnormal_urethra_morphology	0.37067039
70	MP0004019_abnormal_vitamin_homeostasis	0.36785863
71	MP0008961_abnormal_basal_metabolism	0.35875677
72	MP0005620_abnormal_muscle_contractility	0.34919509
73	MP0005369_muscle_phenotype	0.33348286
74	MP0006054_spinal_hemorrhage	0.32511686
75	MP0000470_abnormal_stomach_morphology	0.31370087
76	MP0005375_adipose_tissue_phenotype	0.31259581
77	MP0004130_abnormal_muscle_cell	0.30850581
78	MP0010352_gastrointestinal_tract_polyps	0.29464264
79	MP0004036_abnormal_muscle_relaxation	0.26920602
80	MP0000733_abnormal_muscle_development	0.26425907
81	MP0009384_cardiac_valve_regurgitation	0.26368177
82	MP0002249_abnormal_larynx_morphology	0.26365236
83	MP0002090_abnormal_vision	0.25681203
84	MP0002971_abnormal_brown_adipose	0.25362488
85	MP0000538_abnormal_urinary_bladder	0.25174195
86	MP0002282_abnormal_trachea_morphology	0.24117722
87	MP0004145_abnormal_muscle_electrophysio	0.23537239
88	MP0003329_amyloid_beta_deposits	0.21410103
89	MP0002896_abnormal_bone_mineralization	0.20864427
90	MP0001666_abnormal_nutrient_absorption	0.20048082
91	MP0002108_abnormal_muscle_morphology	0.17682291
92	MP0003448_altered_tumor_morphology	0.17657927
93	MP0002837_dystrophic_cardiac_calcinosis	0.15940808
94	MP0000432_abnormal_head_morphology	0.15567706
95	MP0009333_abnormal_splenocyte_physiolog	0.15402682
96	MP0005076_abnormal_cell_differentiation	0.13822855
97	MP0005330_cardiomyopathy	0.13737145
98	MP0000613_abnormal_salivary_gland	0.13657689
99	MP0003950_abnormal_plasma_membrane	0.13332032
100	MP0001299_abnormal_eye_distance/	0.12231973

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased IgE level (HP:0003212)	9.57251500
2	Conjunctival hamartoma (HP:0100780)	8.38278630
3	Hypotrichosis (HP:0001006)	7.73826003
4	Palmoplantar hyperkeratosis (HP:0000972)	7.43164534
5	Plantar hyperkeratosis (HP:0007556)	7.30150512
6	Palmar hyperkeratosis (HP:0010765)	7.02364251
7	Onycholysis (HP:0001806)	6.40904242
8	Abnormality of nail color (HP:0100643)	6.34738772
9	Erythema (HP:0010783)	6.28161238
10	Erythroderma (HP:0001019)	6.18456498
11	Woolly hair (HP:0002224)	5.88201047
12	Hamartoma of the eye (HP:0010568)	5.40265861
13	Right ventricular cardiomyopathy (HP:0011663)	5.37610619
14	Pili torti (HP:0003777)	5.32447650
15	Thick nail (HP:0001805)	5.20272361
16	Congenital ichthyosiform erythroderma (HP:0007431)	5.09416853
17	Milia (HP:0001056)	5.06596468
18	Fragile nails (HP:0001808)	4.99213337
19	Gangrene (HP:0100758)	4.38566010
20	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	4.27904825
21	Abnormal blistering of the skin (HP:0008066)	4.27674257
22	Nail dystrophy (HP:0008404)	3.85806680
23	Abnormal hair laboratory examination (HP:0003328)	3.82888592
24	Hyporeflexia of lower limbs (HP:0002600)	3.71556052
25	Round ear (HP:0100830)	3.70582572
26	Type 1 muscle fiber predominance (HP:0003803)	3.62621466
27	Muscle fiber inclusion bodies (HP:0100299)	3.53025050
28	Alopecia of scalp (HP:0002293)	3.51450437
29	Palmoplantar keratoderma (HP:0000982)	3.49722261
30	Corneal erosion (HP:0200020)	3.48632140
31	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.44934418
32	Nemaline bodies (HP:0003798)	3.40170085
33	Distal arthrogryposis (HP:0005684)	3.32880306
34	Ectropion (HP:0000656)	3.28336506
35	Eczematoid dermatitis (HP:0000976)	3.19348507
36	Increased connective tissue (HP:0009025)	3.15347378
37	Oral leukoplakia (HP:0002745)	3.13061992
38	Hypohidrosis (HP:0000966)	3.09922373
39	Parakeratosis (HP:0001036)	3.07265888
40	Distal lower limb muscle weakness (HP:0009053)	3.04344747
41	Ventricular tachycardia (HP:0004756)	3.01281895
42	Atrophic scars (HP:0001075)	2.98723149
43	Hypergammaglobulinemia (HP:0010702)	2.87488229
44	Ridged nail (HP:0001807)	2.85119968
45	Exercise-induced myalgia (HP:0003738)	2.81437050
46	Myopathic facies (HP:0002058)	2.80977321
47	Curly hair (HP:0002212)	2.77902819
48	Pruritus (HP:0000989)	2.72367123
49	Ulnar deviation of the wrist (HP:0003049)	2.68388684
50	Follicular hyperkeratosis (HP:0007502)	2.64282698
51	Sparse eyelashes (HP:0000653)	2.60847876
52	Calcaneovalgus deformity (HP:0001848)	2.57996671
53	Advanced eruption of teeth (HP:0006288)	2.55877235
54	Lip pit (HP:0100267)	2.51736991
55	Areflexia of lower limbs (HP:0002522)	2.51139369
56	Hamartoma (HP:0010566)	2.50448973
57	Muscle fiber splitting (HP:0003555)	2.43091115
58	Natal tooth (HP:0000695)	2.33501057
59	Abnormality of the neuromuscular junction (HP:0003398)	2.30861533
60	Fatigable weakness (HP:0003473)	2.30861533
61	Deformed tarsal bones (HP:0008119)	2.26104000
62	Absent phalangeal crease (HP:0006109)	2.18631820
63	Distal lower limb amyotrophy (HP:0008944)	2.13036953
64	Lack of skin elasticity (HP:0100679)	2.09313541
65	Melanocytic nevus (HP:0000995)	2.03928670
66	Exercise-induced muscle cramps (HP:0003710)	2.02023396
67	Difficulty running (HP:0009046)	2.00972264
68	Malignant hyperthermia (HP:0002047)	2.00495440
69	Acanthosis nigricans (HP:0000956)	2.00331746
70	Fragile skin (HP:0001030)	1.99688051
71	Abnormality of skeletal muscle fiber size (HP:0012084)	1.97793929
72	Brittle hair (HP:0002299)	1.97516390
73	Hyperhidrosis (HP:0000975)	1.94845328
74	Papilloma (HP:0012740)	1.94345362
75	Verrucae (HP:0200043)	1.94345362
76	Increased variability in muscle fiber diameter (HP:0003557)	1.92343412
77	Sudden death (HP:0001699)	1.89114616
78	Neck muscle weakness (HP:0000467)	1.88066247
79	Achilles tendon contracture (HP:0001771)	1.85135240
80	Blepharitis (HP:0000498)	1.82540740
81	Neonatal onset (HP:0003623)	1.81070164
82	Abnormal finger flexion creases (HP:0006143)	1.78214451
83	Concave nail (HP:0001598)	1.78059036
84	Skin ulcer (HP:0200042)	1.77577992
85	Abnormality of the Achilles tendon (HP:0005109)	1.70565146
86	Ventricular fibrillation (HP:0001663)	1.69978290
87	Frequent falls (HP:0002359)	1.68944999
88	Paralysis (HP:0003470)	1.68570590
89	Abnormality of secondary sexual hair (HP:0009888)	1.62474565
90	Abnormality of the axillary hair (HP:0100134)	1.62474565
91	Sparse scalp hair (HP:0002209)	1.57752427
92	Abnormality of the salivary glands (HP:0010286)	1.56898167
93	Severe Myopia (HP:0011003)	1.55888928
94	Lower limb amyotrophy (HP:0007210)	1.54806667
95	Anonychia (HP:0001798)	1.53336645
96	Spinal rigidity (HP:0003306)	1.53229116
97	Dehydration (HP:0001944)	1.52813743
98	Aplasia cutis congenita (HP:0001057)	1.49724922
99	Autoimmune hemolytic anemia (HP:0001890)	1.47935718
100	Abnormality of the calcaneus (HP:0008364)	1.46713355

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPKAPK3	4.92001734
2	TTN	4.29346466
3	PIK3CG	3.91683260
4	FER	3.66473166
5	MST1R	3.60363901
6	OBSCN	3.47369190
7	MAP3K3	3.43279363
8	FGFR1	2.57399718
9	TAOK1	2.49509503
10	RIPK1	2.15813821
11	EEF2K	2.14809898
12	ERN1	2.10105359
13	MAP2K6	2.05729742
14	MAP3K11	2.04189034
15	BCR	1.99587353
16	RPS6KB2	1.93148075
17	MAP3K2	1.93057143
18	MAP2K3	1.87285803
19	EPHB2	1.78276544
20	LATS1	1.72384576
21	NME1	1.68497097
22	PHKG2	1.64756744
23	PHKG1	1.64756744
24	FGFR2	1.61630731
25	NTRK2	1.59399935
26	TRIB3	1.57786497
27	MAP3K7	1.46781563
28	MAPKAPK5	1.39399882
29	TIE1	1.27309195
30	MAP3K1	1.24053232
31	EPHA2	1.19192623
32	TRPM7	1.15338808
33	MAP3K9	1.08538122
34	MET	1.06564779
35	DYRK1B	1.04794107
36	MST4	1.00548754
37	CDK6	1.00059333
38	DMPK	0.98309971
39	LATS2	0.97656696
40	EPHB1	0.97510476
41	TAOK2	0.97223420
42	MAPKAPK2	0.94136831
43	PTK6	0.92824996
44	STK11	0.89841973
45	FGFR4	0.88456757
46	NEK1	0.86621790
47	BLK	0.84634300
48	SIK1	0.82507277
49	MAP2K4	0.81888573
50	EPHA3	0.77994112
51	LRRK2	0.70298359
52	STK24	0.67937863
53	MAPK12	0.67486095
54	FGFR3	0.58766267
55	MAP2K1	0.57336260
56	PRKD1	0.53293754
57	TYK2	0.53221974
58	TYRO3	0.52937190
59	BMX	0.51969407
60	KSR2	0.51786607
61	PRKCI	0.51109808
62	DDR2	0.48797142
63	ERBB3	0.46988861
64	DAPK2	0.43990125
65	PKN1	0.43367462
66	PTK2	0.42609100
67	PIM2	0.41686271
68	HCK	0.41423303
69	BRD4	0.40893445
70	MAPK11	0.38180972
71	FGR	0.36011570
72	GSK3A	0.35961675
73	ILK	0.33205696
74	PRKAA2	0.33082605
75	MAP3K6	0.30709208
76	ITK	0.29907914
77	MAPK4	0.27499939
78	RPS6KA1	0.26571663
79	FYN	0.25713085
80	RPS6KA4	0.25447545
81	TGFBR2	0.24721113
82	MAP3K14	0.24537915
83	PDK4	0.24467331
84	PDK3	0.24467331
85	MAP3K5	0.23861425
86	ROCK2	0.23822952
87	PRKD2	0.23641452
88	PRKACA	0.23182155
89	ROCK1	0.22817891
90	TGFBR1	0.20440670
91	PAK3	0.19925715
92	CDK4	0.18864807
93	RET	0.18616772
94	PDGFRA	0.18106762
95	RIPK4	0.17472563
96	ERBB2	0.17388348
97	MARK2	0.16842887
98	SRC	0.16566130
99	PKN2	0.16135243
100	SGK1	0.16061708

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid elongation_Homo sapiens_hsa00062	3.73768231
2	Linoleic acid metabolism_Homo sapiens_hsa00591	3.40350583
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.38243621
4	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.44000032
5	Phenylalanine metabolism_Homo sapiens_hsa00360	2.29585189
6	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.20902741
7	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.20861572
8	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	2.15378983
9	Fat digestion and absorption_Homo sapiens_hsa04975	2.11881980
10	Ether lipid metabolism_Homo sapiens_hsa00565	1.96193175
11	Histidine metabolism_Homo sapiens_hsa00340	1.80465845
12	Sphingolipid metabolism_Homo sapiens_hsa00600	1.72168271
13	Basal cell carcinoma_Homo sapiens_hsa05217	1.66998177
14	GnRH signaling pathway_Homo sapiens_hsa04912	1.65652794
15	VEGF signaling pathway_Homo sapiens_hsa04370	1.65008771
16	Renin secretion_Homo sapiens_hsa04924	1.44559183
17	Phototransduction_Homo sapiens_hsa04744	1.43130555
18	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.35892970
19	ECM-receptor interaction_Homo sapiens_hsa04512	1.33042411
20	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.30369735
21	Bladder cancer_Homo sapiens_hsa05219	1.23767303
22	Axon guidance_Homo sapiens_hsa04360	1.23518400
23	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.22404509
24	Tight junction_Homo sapiens_hsa04530	1.18307777
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.17776350
26	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.15446612
27	Salivary secretion_Homo sapiens_hsa04970	1.13149477
28	Tyrosine metabolism_Homo sapiens_hsa00350	1.12974008
29	Steroid biosynthesis_Homo sapiens_hsa00100	1.07694538
30	Long-term depression_Homo sapiens_hsa04730	1.06510441
31	Melanogenesis_Homo sapiens_hsa04916	1.06264453
32	Proteoglycans in cancer_Homo sapiens_hsa05205	1.05210891
33	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.03531329
34	Gastric acid secretion_Homo sapiens_hsa04971	1.01456931
35	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.99001292
36	Amoebiasis_Homo sapiens_hsa05146	0.98489335
37	beta-Alanine metabolism_Homo sapiens_hsa00410	0.97214171
38	Pancreatic secretion_Homo sapiens_hsa04972	0.96807974
39	Adherens junction_Homo sapiens_hsa04520	0.95601648
40	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.90980173
41	ABC transporters_Homo sapiens_hsa02010	0.88727603
42	Ras signaling pathway_Homo sapiens_hsa04014	0.87200883
43	PPAR signaling pathway_Homo sapiens_hsa03320	0.87049440
44	Calcium signaling pathway_Homo sapiens_hsa04020	0.86538885
45	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.86447941
46	Hippo signaling pathway_Homo sapiens_hsa04390	0.86370977
47	Platelet activation_Homo sapiens_hsa04611	0.86294930
48	Pertussis_Homo sapiens_hsa05133	0.85227920
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84321933
50	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.84118639
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82745650
52	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.81983233
53	Glioma_Homo sapiens_hsa05214	0.76744246
54	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.76228051
55	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.75494420
56	Protein digestion and absorption_Homo sapiens_hsa04974	0.75022617
57	Retinol metabolism_Homo sapiens_hsa00830	0.74055816
58	Long-term potentiation_Homo sapiens_hsa04720	0.70726260
59	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.69852120
60	Olfactory transduction_Homo sapiens_hsa04740	0.69608496
61	Toxoplasmosis_Homo sapiens_hsa05145	0.68855928
62	Insulin resistance_Homo sapiens_hsa04931	0.68775582
63	Serotonergic synapse_Homo sapiens_hsa04726	0.68257656
64	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.67991967
65	Acute myeloid leukemia_Homo sapiens_hsa05221	0.67109236
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65668217
67	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.63201721
68	Glucagon signaling pathway_Homo sapiens_hsa04922	0.62813632
69	Focal adhesion_Homo sapiens_hsa04510	0.61466752
70	Fatty acid degradation_Homo sapiens_hsa00071	0.60852047
71	Non-small cell lung cancer_Homo sapiens_hsa05223	0.59279906
72	Rap1 signaling pathway_Homo sapiens_hsa04015	0.58185053
73	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.57616613
74	MicroRNAs in cancer_Homo sapiens_hsa05206	0.57304266
75	Estrogen signaling pathway_Homo sapiens_hsa04915	0.55705228
76	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.55244138
77	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.55239424
78	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.52555106
79	Fatty acid metabolism_Homo sapiens_hsa01212	0.51603907
80	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.49160862
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49040981
82	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47699300
83	Insulin signaling pathway_Homo sapiens_hsa04910	0.45621893
84	Thyroid cancer_Homo sapiens_hsa05216	0.45204639
85	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.44460905
86	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.44420143
87	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.44054724
88	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.40457769
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40227295
90	Salmonella infection_Homo sapiens_hsa05132	0.37470342
91	ErbB signaling pathway_Homo sapiens_hsa04012	0.37299738
92	Notch signaling pathway_Homo sapiens_hsa04330	0.36618185
93	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.36400019
94	Small cell lung cancer_Homo sapiens_hsa05222	0.36196547
95	p53 signaling pathway_Homo sapiens_hsa04115	0.35797022
96	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.34972575
97	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.34726475
98	Circadian entrainment_Homo sapiens_hsa04713	0.33605198
99	Wnt signaling pathway_Homo sapiens_hsa04310	0.33442492
100	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.33390901

LCE1D

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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