LCE2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.70741215
2long-chain fatty acid biosynthetic process (GO:0042759)9.41957345
3water homeostasis (GO:0030104)9.34012999
4peptide cross-linking (GO:0018149)9.14784849
5skin morphogenesis (GO:0043589)8.94914246
6epidermal cell differentiation (GO:0009913)8.74381854
7detection of bacterium (GO:0016045)7.87247833
8keratinocyte proliferation (GO:0043616)7.77699713
9lipoxygenase pathway (GO:0019372)7.70232606
10linoleic acid metabolic process (GO:0043651)7.43436037
11epidermis development (GO:0008544)7.43293428
12detection of other organism (GO:0098543)7.28021458
13bundle of His cell to Purkinje myocyte communication (GO:0086069)6.97572754
14regulation of natural killer cell differentiation (GO:0032823)6.33712637
15molting cycle (GO:0042303)6.08928714
16hair cycle (GO:0042633)6.08928714
17surfactant homeostasis (GO:0043129)5.76702185
18negative regulation of interferon-gamma production (GO:0032689)5.27229001
19phosphatidylinositol acyl-chain remodeling (GO:0036149)5.20958944
20gap junction assembly (GO:0016264)5.15413686
21phosphatidylserine acyl-chain remodeling (GO:0036150)5.12961215
22chemical homeostasis within a tissue (GO:0048875)4.84979515
23intermediate filament cytoskeleton organization (GO:0045104)4.43432294
24intermediate filament organization (GO:0045109)4.34571319
25detection of external biotic stimulus (GO:0098581)4.30639188
26intermediate filament-based process (GO:0045103)4.30096732
27establishment of planar polarity (GO:0001736)4.20745832
28establishment of tissue polarity (GO:0007164)4.20745832
29ectoderm development (GO:0007398)4.20490135
30phospholipid efflux (GO:0033700)4.13039147
31phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.12667993
32positive regulation of monocyte chemotaxis (GO:0090026)4.10177625
33polarized epithelial cell differentiation (GO:0030859)4.05192633
34ceramide biosynthetic process (GO:0046513)4.05059748
35positive regulation of cholesterol efflux (GO:0010875)3.97502351
36lateral sprouting from an epithelium (GO:0060601)3.92709329
37negative regulation of interleukin-17 production (GO:0032700)3.85840965
38keratinocyte development (GO:0003334)3.81121180
39positive regulation of T cell chemotaxis (GO:0010820)3.80075196
40regulation of T cell chemotaxis (GO:0010819)3.80075196
41phosphatidylcholine acyl-chain remodeling (GO:0036151)3.70502170
42phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.69563682
43detection of biotic stimulus (GO:0009595)3.68019634
44hemidesmosome assembly (GO:0031581)3.63341380
45sequestering of metal ion (GO:0051238)3.57146321
46epithelium development (GO:0060429)3.48895742
47positive regulation of cholesterol transport (GO:0032376)3.43599691
48positive regulation of sterol transport (GO:0032373)3.43599691
49phosphatidylserine metabolic process (GO:0006658)3.25850220
50regulation of natural killer cell activation (GO:0032814)3.16720813
51regulation of monocyte chemotaxis (GO:0090025)3.10461146
52epithelial cell differentiation involved in prostate gland development (GO:0060742)3.08669628
53negative regulation of keratinocyte proliferation (GO:0010839)3.07894039
54* keratinization (GO:0031424)29.3267939
55establishment of skin barrier (GO:0061436)20.7603989
56regulation of protein localization to cell surface (GO:2000008)2.96276069
57phospholipid catabolic process (GO:0009395)2.94418908
58regulation of keratinocyte differentiation (GO:0045616)2.82079930
59regulation of keratinocyte proliferation (GO:0010837)2.80142743
60eyelid development in camera-type eye (GO:0061029)2.67917057
61alditol phosphate metabolic process (GO:0052646)2.66417529
62sphingolipid biosynthetic process (GO:0030148)2.63380746
63ventricular cardiac muscle cell action potential (GO:0086005)2.61273149
64planar cell polarity pathway involved in neural tube closure (GO:0090179)2.60185313
65regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.57768353
66defense response to Gram-negative bacterium (GO:0050829)2.54669997
67fatty acid elongation (GO:0030497)2.53966891
68positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.52928710
69regulation of cholesterol efflux (GO:0010874)2.49728965
70positive regulation of epidermis development (GO:0045684)2.47282433
71defense response to fungus (GO:0050832)2.45286294
72one-carbon compound transport (GO:0019755)2.44258156
73regulation of axon regeneration (GO:0048679)2.37028092
74regulation of neuron projection regeneration (GO:0070570)2.37028092
75polyol transport (GO:0015791)2.34001710
76epithelial cell differentiation (GO:0030855)2.33152818
77negative regulation of lymphocyte differentiation (GO:0045620)2.31557114
78regulation of heart rate by cardiac conduction (GO:0086091)2.30974611
79antimicrobial humoral response (GO:0019730)2.29249824
80regulation of epidermis development (GO:0045682)2.28287016
81hair follicle morphogenesis (GO:0031069)2.26121883
82positive regulation of epidermal cell differentiation (GO:0045606)2.24882451
83regulation of lymphocyte chemotaxis (GO:1901623)2.20868954
84regulation of interleukin-17 production (GO:0032660)2.17585000
85signal transduction in absence of ligand (GO:0038034)2.16306281
86extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)2.16306281
87unsaturated fatty acid biosynthetic process (GO:0006636)2.14925955
88cell communication involved in cardiac conduction (GO:0086065)2.14898163
89regulation of epidermal cell differentiation (GO:0045604)2.12717868
90atrioventricular valve morphogenesis (GO:0003181)2.12281660
91skin development (GO:0043588)2.08878684
92intestinal epithelial cell development (GO:0060576)2.08676282
93positive regulation of granulocyte chemotaxis (GO:0071624)2.08504810
94smooth muscle tissue development (GO:0048745)2.06853874
95epithelial cell proliferation (GO:0050673)2.05284486
96membrane lipid biosynthetic process (GO:0046467)2.00791394
97regulation of water loss via skin (GO:0033561)17.8738397
98keratinocyte differentiation (GO:0030216)11.4430868
99multicellular organismal water homeostasis (GO:0050891)11.2208268
100phosphatidylglycerol metabolic process (GO:0046471)1.98186907

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.15183502
2P63_26484246_Chip-Seq_KERATINOCYTES_Human4.17436813
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.68145806
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.41166008
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.80945558
6SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.45622893
7SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.45622893
8TP63_23658742_ChIP-Seq_EP156T_Human2.27504788
9SOX9_24532713_ChIP-Seq_HFSC_Mouse2.22727745
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.17297857
11TP63_17297297_ChIP-ChIP_HaCaT_Human12.2516653
12GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.91739791
13ZNF217_24962896_ChIP-Seq_MCF-7_Human1.86044640
14RXR_22108803_ChIP-Seq_LS180_Human1.83713178
15* TP63_22573176_ChIP-Seq_HFKS_Human1.70650041
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.66114038
17GATA6_21074721_ChIP-Seq_CACO-2_Human1.64619374
18VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.62176051
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.61686287
20EGR1_19032775_ChIP-ChIP_M12_Human1.58297741
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55659383
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.52856229
23CJUN_26792858_Chip-Seq_BT549_Human1.47090413
24AR_21572438_ChIP-Seq_LNCaP_Human1.46017619
25ERG_20517297_ChIP-Seq_VCAP_Human1.32753746
26TP53_18474530_ChIP-ChIP_U2OS_Human1.30430074
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28935449
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28811276
29AHR_22903824_ChIP-Seq_MCF-7_Human1.24256607
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22608029
31* CTCF_27219007_Chip-Seq_Bcells_Human1.22405097
32SOX2_20726797_ChIP-Seq_SW620_Human1.21974792
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.20681250
34GATA3_24758297_ChIP-Seq_MCF-7_Human1.20011340
35* UBF1/2_26484160_Chip-Seq_HMECs_Human1.10483878
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.08549435
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08465200
38GATA1_22025678_ChIP-Seq_K562_Human1.06196770
39ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06134648
40ATF3_27146783_Chip-Seq_COLON_Human1.06024182
41JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00974388
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00205825
43* KLF5_25053715_ChIP-Seq_YYC3_Human0.97863938
44FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96846377
45RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96638979
46ARNT_22903824_ChIP-Seq_MCF-7_Human0.94980509
47E2F1_20622854_ChIP-Seq_HELA_Human0.94023061
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93636694
49GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92801391
50CTCF_20526341_ChIP-Seq_ESCs_Human0.91374886
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91185567
52NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91185567
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89874055
54FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88765835
55RUNX1_27514584_Chip-Seq_MCF-7_Human0.88753047
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87383409
57BCOR_27268052_Chip-Seq_Bcells_Human0.87228604
58DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87181759
59P53_21459846_ChIP-Seq_SAOS-2_Human0.86787502
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86722448
61P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86183706
62HNFA_21074721_ChIP-Seq_CACO-2_Human0.86159155
63PIAS1_25552417_ChIP-Seq_VCAP_Human0.85842464
64PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84854035
65ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84674165
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81468939
67FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80920008
68JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80674097
69GATA2_21666600_ChIP-Seq_HMVEC_Human0.80286103
70CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80209334
71SMAD4_21799915_ChIP-Seq_A2780_Human0.79999772
72SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79973411
73CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.79769198
74TP53_16413492_ChIP-PET_HCT116_Human0.79721982
75TAF2_19829295_ChIP-Seq_ESCs_Human0.78466625
76RACK7_27058665_Chip-Seq_MCF-7_Human0.78383180
77SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77559604
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77506722
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77493179
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.76367958
81CLOCK_20551151_ChIP-Seq_293T_Human0.75798603
82P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.74611071
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73928005
84MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.73368433
85RBPJ_21746931_ChIP-Seq_IB4_Human0.72535131
86PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.71864528
87SMAD3_21741376_ChIP-Seq_HESCs_Human0.71004696
88SMAD4_21741376_ChIP-Seq_ESCs_Human0.70095093
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.69603858
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.69432675
91TCF4_22108803_ChIP-Seq_LS180_Human0.68243886
92EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.68130842
93GATA4_25053715_ChIP-Seq_YYC3_Human0.67710992
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.67566577
95RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.67236159
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.67046953
97SMC4_20622854_ChIP-Seq_HELA_Human0.66925418
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66621453
99GATA2_19941826_ChIP-Seq_K562_Human0.64565279
100CDX2_22108803_ChIP-Seq_LS180_Human0.64311099

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile7.73980020
2MP0005501_abnormal_skin_physiology6.02356117
3MP0000579_abnormal_nail_morphology4.96777682
4MP0003941_abnormal_skin_development4.58088687
5MP0010234_abnormal_vibrissa_follicle3.38638297
6MP0003191_abnormal_cellular_cholesterol3.30227375
7MP0001216_abnormal_epidermal_layer3.14812845
8MP0010771_integument_phenotype2.88133749
9MP0004885_abnormal_endolymph2.78202202
10MP0003878_abnormal_ear_physiology2.73267678
11MP0005377_hearing/vestibular/ear_phenot2.73267678
12MP0004947_skin_inflammation2.72606168
13MP0003453_abnormal_keratinocyte_physiol2.68942276
14MP0002060_abnormal_skin_morphology2.60727550
15MP0004782_abnormal_surfactant_physiolog2.14025678
16MP0000377_abnormal_hair_follicle2.06193945
17MP0002796_impaired_skin_barrier11.0338694
18MP0010678_abnormal_skin_adnexa1.98964095
19MP0010352_gastrointestinal_tract_polyps1.88772494
20MP0003705_abnormal_hypodermis_morpholog1.83277763
21MP0000383_abnormal_hair_follicle1.81374800
22MP0001188_hyperpigmentation1.75531200
23MP0009931_abnormal_skin_appearance1.71996117
24MP0000467_abnormal_esophagus_morphology1.70572792
25MP0004381_abnormal_hair_follicle1.69936430
26MP0002098_abnormal_vibrissa_morphology1.68969568
27MP0001191_abnormal_skin_condition1.66566451
28MP0005409_darkened_coat_color1.58961821
29MP0000647_abnormal_sebaceous_gland1.47899719
30MP0004264_abnormal_extraembryonic_tissu1.46078674
31MP0003566_abnormal_cell_adhesion1.45819473
32MP0009379_abnormal_foot_pigmentation1.42494077
33MP0000566_synostosis1.19809819
34MP0003011_delayed_dark_adaptation1.17114322
35MP0000427_abnormal_hair_cycle1.11947979
36MP0000367_abnormal_coat/_hair1.11636526
37MP0000465_gastrointestinal_hemorrhage1.09967917
38MP0002095_abnormal_skin_pigmentation1.09203655
39MP0000762_abnormal_tongue_morphology1.08102231
40MP0001784_abnormal_fluid_regulation1.02507570
41MP0001243_abnormal_dermal_layer0.90623513
42MP0005023_abnormal_wound_healing0.87283211
43MP0009053_abnormal_anal_canal0.85655058
44MP0001851_eye_inflammation0.69081472
45MP0002138_abnormal_hepatobiliary_system0.65792247
46MP0008438_abnormal_cutaneous_collagen0.65486539
47MP0003950_abnormal_plasma_membrane0.58953635
48MP0000015_abnormal_ear_pigmentation0.56822360
49MP0005503_abnormal_tendon_morphology0.55455454
50MP0002177_abnormal_outer_ear0.53088942
51MP0005174_abnormal_tail_pigmentation0.50355212
52MP0002234_abnormal_pharynx_morphology0.49804370
53MP0008004_abnormal_stomach_pH0.49357025
54MP0001177_atelectasis0.46350169
55MP0000569_abnormal_digit_pigmentation0.45607712
56MP0009780_abnormal_chondrocyte_physiolo0.42126744
57MP0001340_abnormal_eyelid_morphology0.38897479
58MP0005388_respiratory_system_phenotype0.37515967
59MP0002133_abnormal_respiratory_system0.37515967
60MP0004197_abnormal_fetal_growth/weight/0.36685703
61MP0009672_abnormal_birth_weight0.36476520
62MP0004185_abnormal_adipocyte_glucose0.36217478
63MP0001485_abnormal_pinna_reflex0.34345254
64MP0003315_abnormal_perineum_morphology0.33528207
65MP0004272_abnormal_basement_membrane0.30877581
66MP0008789_abnormal_olfactory_epithelium0.29725956
67MP0003638_abnormal_response/metabolism_0.26198220
68MP0000627_abnormal_mammary_gland0.25752853
69MP0005499_abnormal_olfactory_system0.24452727
70MP0005394_taste/olfaction_phenotype0.24452727
71MP0001958_emphysema0.22997866
72MP0002697_abnormal_eye_size0.22912705
73MP0003763_abnormal_thymus_physiology0.22786702
74MP0010030_abnormal_orbit_morphology0.20739933
75MP0005257_abnormal_intraocular_pressure0.19806077
76MP0000428_abnormal_craniofacial_morphol0.19145807
77MP0002111_abnormal_tail_morphology0.19121894
78MP0002877_abnormal_melanocyte_morpholog0.18721313
79MP0000432_abnormal_head_morphology0.18519316
80MP0003755_abnormal_palate_morphology0.18230770
81MP0003279_aneurysm0.17451648
82MP0000858_altered_metastatic_potential0.17168303
83MP0001542_abnormal_bone_strength0.16904798
84MP0000685_abnormal_immune_system0.16735001
85MP0003828_pulmonary_edema0.15868907
86MP0003436_decreased_susceptibility_to0.15465647
87MP0002282_abnormal_trachea_morphology0.15156723
88MP0005193_abnormal_anterior_eye0.14302070
89MP0009333_abnormal_splenocyte_physiolog0.14034466
90MP0001299_abnormal_eye_distance/0.14003299
91MP0001186_pigmentation_phenotype0.12788423
92MP0009384_cardiac_valve_regurgitation0.12073764
93MP0005375_adipose_tissue_phenotype0.11681462
94MP0000003_abnormal_adipose_tissue0.10910013
95MP0002295_abnormal_pulmonary_circulatio0.10696064
96MP0003045_fibrosis0.08932651
97MP0005508_abnormal_skeleton_morphology0.08754497
98MP0008569_lethality_at_weaning0.07970031
99MP0006138_congestive_heart_failure0.07683837
100MP0002233_abnormal_nose_morphology0.06547560

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.20026159
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)8.66767452
3Congenital ichthyosiform erythroderma (HP:0007431)8.49897359
4Onycholysis (HP:0001806)7.84787539
5Palmoplantar hyperkeratosis (HP:0000972)7.53106241
6Erythroderma (HP:0001019)7.36522853
7Palmar hyperkeratosis (HP:0010765)7.16526441
8Alopecia of scalp (HP:0002293)6.96667434
9Abnormality of the axillary hair (HP:0100134)6.48216031
10Abnormality of secondary sexual hair (HP:0009888)6.48216031
11Corneal erosion (HP:0200020)6.46821356
12Hypotrichosis (HP:0001006)6.29265126
13Plantar hyperkeratosis (HP:0007556)5.99794956
14Parakeratosis (HP:0001036)5.80499193
15Erythema (HP:0010783)5.70588195
16Oral leukoplakia (HP:0002745)5.66247048
17Thick nail (HP:0001805)5.24121475
18Ectropion (HP:0000656)5.05257578
19Hypohidrosis (HP:0000966)4.84094441
20Gangrene (HP:0100758)4.69353995
21Palmoplantar keratoderma (HP:0000982)4.38977591
22Right ventricular cardiomyopathy (HP:0011663)4.22872568
23Absent eyelashes (HP:0000561)3.94393990
24Woolly hair (HP:0002224)3.66695727
25Sparse eyelashes (HP:0000653)3.65876400
26Absent hair (HP:0002298)3.65248136
27Nail dystrophy (HP:0008404)3.64903999
28Pruritus (HP:0000989)3.31546251
29Conjunctival hamartoma (HP:0100780)3.13109220
30Lack of skin elasticity (HP:0100679)3.00830609
31Lip pit (HP:0100267)3.00371164
32Furrowed tongue (HP:0000221)2.88706238
33Follicular hyperkeratosis (HP:0007502)2.81319093
34Abnormality of the salivary glands (HP:0010286)2.80855086
35Autoamputation (HP:0001218)2.77459613
36Sparse scalp hair (HP:0002209)2.74783021
37Amniotic constriction ring (HP:0009775)2.74196651
38Abnormality of placental membranes (HP:0011409)2.74196651
39Fragile nails (HP:0001808)2.73463524
40Pustule (HP:0200039)2.70375048
41Abnormal blistering of the skin (HP:0008066)2.69606489
42Blepharitis (HP:0000498)2.63150405
43Eczematoid dermatitis (HP:0000976)2.50834306
44Hypergammaglobulinemia (HP:0010702)2.37832898
45Hypoplastic labia majora (HP:0000059)2.27036983
46Selective tooth agenesis (HP:0001592)2.20752735
47Paralysis (HP:0003470)2.14981038
48Abnormal hair laboratory examination (HP:0003328)2.11560642
49Hamartoma of the eye (HP:0010568)2.11358159
50Dehydration (HP:0001944)2.09510640
51Recurrent corneal erosions (HP:0000495)2.08404251
52Slow-growing hair (HP:0002217)2.08218529
53Abnormality of hair growth rate (HP:0011363)2.08218529
54Abnormality of the labia majora (HP:0012881)2.06368138
55Multifactorial inheritance (HP:0001426)2.04816518
56Abnormality of nail color (HP:0100643)12.9016320
57Urticaria (HP:0001025)1.99920753
58Split foot (HP:0001839)1.97239627
59Brittle hair (HP:0002299)1.95189733
60Sepsis (HP:0100806)1.94018238
61Laryngomalacia (HP:0001601)1.90332895
62Natal tooth (HP:0000695)1.90118815
63Curly hair (HP:0002212)1.79678770
64Melanocytic nevus (HP:0000995)1.79444297
65Septate vagina (HP:0001153)1.77418819
66Depressed nasal tip (HP:0000437)1.76426210
67Hyperhidrosis (HP:0000975)1.75801714
68Dry skin (HP:0000958)1.73742155
69Duplicated collecting system (HP:0000081)1.72458734
70Anhidrosis (HP:0000970)1.67938661
71Milia (HP:0001056)1.66766356
72Keratoconjunctivitis sicca (HP:0001097)1.66758456
73Advanced eruption of teeth (HP:0006288)1.65889464
74Hypoplastic toenails (HP:0001800)1.65187927
75Pili torti (HP:0003777)1.64277407
76Xerostomia (HP:0000217)1.64068174
77Ridged nail (HP:0001807)1.62140883
78Malignant hyperthermia (HP:0002047)1.59196910
79Breast hypoplasia (HP:0003187)1.58936139
80Anonychia (HP:0001798)1.57641261
81Fine hair (HP:0002213)1.56166200
82Carious teeth (HP:0000670)1.55758795
83Generalized hyperpigmentation (HP:0007440)1.54796194
84Skin ulcer (HP:0200042)1.53293985
85Recurrent bacterial skin infections (HP:0005406)1.51060806
86Acanthosis nigricans (HP:0000956)1.50830818
87Nasolacrimal duct obstruction (HP:0000579)1.50657223
88Conical tooth (HP:0000698)1.50210777
89Oligodontia (HP:0000677)1.50014516
90Keratoconjunctivitis (HP:0001096)1.49730904
91Preauricular skin tag (HP:0000384)1.46333660
92Abnormality of the renal collecting system (HP:0004742)1.45156210
93Abnormality of permanent molar morphology (HP:0011071)1.44115097
94Abnormality of the dental root (HP:0006486)1.44115097
95Taurodontia (HP:0000679)1.44115097
96Everted lower lip vermilion (HP:0000232)1.40416773
97Abnormality of the fingernails (HP:0001231)1.40358974
98Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.40306709
99Abnormality of molar morphology (HP:0011070)1.39444509
100Abnormality of molar (HP:0011077)1.39444509

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR17.25912866
2FER3.31381173
3FGFR12.95736075
4STK242.81508356
5ERN12.79597924
6EPHA22.64007382
7MAP3K92.62510428
8MAP3K62.54845142
9MAP3K22.30637018
10RIPK12.30459907
11PIK3CG2.29989453
12MET2.09054729
13SGK4942.05762745
14SGK2232.05762745
15WNK12.01830109
16MAP3K31.91527243
17AKT31.90176169
18GRK61.83371975
19PDGFRA1.65935153
20LATS11.60418549
21MAPKAPK31.59033014
22PTK21.58020366
23EPHA31.48490727
24MAPK71.41652946
25TGFBR21.40216714
26FLT31.39065474
27EPHB11.38713062
28FGFR31.30929753
29EEF2K1.30508711
30CDK121.30094745
31IRAK11.26506485
32TRPM71.26036938
33DMPK1.18702227
34IKBKB1.17790249
35MYLK1.06184930
36SGK21.03759314
37MAP3K11.00925102
38NTRK11.00827074
39ADRBK10.99886282
40RPS6KB10.93893945
41STK380.88223510
42LATS20.88027602
43MAPK120.86108442
44SGK30.84607168
45MAP2K60.81566420
46STK30.78660403
47MAPKAPK20.78638429
48PDGFRB0.77233732
49NLK0.76794288
50MST1R0.74840891
51CDC42BPA0.73673978
52CAMK1G0.72215517
53PAK20.72095835
54PIM20.71114002
55TXK0.70291839
56MARK20.70253321
57MTOR0.67097862
58ZAP700.63430867
59TAOK10.63221246
60CAMK1D0.62045041
61MAP3K70.54098525
62MAPKAPK50.53829177
63GSK3A0.53342646
64BRD40.53027000
65JAK30.52581962
66FRK0.52078222
67GRK70.50813635
68PRKD20.50102012
69PRKCE0.48750976
70FGFR20.48428412
71BLK0.48383839
72IRAK20.47892381
73SGK10.47782928
74STK38L0.47705823
75DDR20.46616635
76MST40.45844350
77TAOK30.45350027
78MOS0.44861469
79ABL10.44083470
80ERBB40.43575944
81KIT0.43146523
82LRRK20.41135508
83SIK10.40416865
84PKN10.37464248
85PRKAA20.36809165
86IKBKE0.36690332
87MAP3K50.36073932
88ABL20.34576259
89MAPK40.32526000
90TYRO30.31980913
91FGFR40.31461024
92RPS6KA20.30808633
93RET0.30458603
94IRAK30.30418028
95CHUK0.29677382
96HIPK20.27486596
97ACVR1B0.26611954
98EPHB20.26358434
99KSR20.24988832
100CDK60.22075408

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.83950103
2Linoleic acid metabolism_Homo sapiens_hsa005914.67013356
3Arachidonic acid metabolism_Homo sapiens_hsa005903.44679291
4Ether lipid metabolism_Homo sapiens_hsa005653.35146050
5Sphingolipid metabolism_Homo sapiens_hsa006002.53656210
6GnRH signaling pathway_Homo sapiens_hsa049122.41171000
7Phototransduction_Homo sapiens_hsa047442.17822116
8Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.09296760
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99890711
10Ovarian steroidogenesis_Homo sapiens_hsa049131.97787887
11VEGF signaling pathway_Homo sapiens_hsa043701.97345425
12Long-term depression_Homo sapiens_hsa047301.81041334
13Vascular smooth muscle contraction_Homo sapiens_hsa042701.74041644
14Histidine metabolism_Homo sapiens_hsa003401.68006479
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.65526308
16Circadian rhythm_Homo sapiens_hsa047101.56391179
17Renin secretion_Homo sapiens_hsa049241.54486980
18Amoebiasis_Homo sapiens_hsa051461.52146122
19Serotonergic synapse_Homo sapiens_hsa047261.49987703
20Staphylococcus aureus infection_Homo sapiens_hsa051501.39277128
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.38763470
22Choline metabolism in cancer_Homo sapiens_hsa052311.37025727
23ABC transporters_Homo sapiens_hsa020101.32974586
24Glioma_Homo sapiens_hsa052141.29872711
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.29790538
26Ras signaling pathway_Homo sapiens_hsa040141.25742387
27Dorso-ventral axis formation_Homo sapiens_hsa043201.19891907
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17168228
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07787875
30Platelet activation_Homo sapiens_hsa046111.07409079
31Pertussis_Homo sapiens_hsa051331.04645946
32Oxytocin signaling pathway_Homo sapiens_hsa049211.04034495
33Acute myeloid leukemia_Homo sapiens_hsa052211.01183801
34Sphingolipid signaling pathway_Homo sapiens_hsa040710.97679561
35Melanogenesis_Homo sapiens_hsa049160.97529212
36Phospholipase D signaling pathway_Homo sapiens_hsa040720.95007747
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93961378
38ECM-receptor interaction_Homo sapiens_hsa045120.93349315
39Adherens junction_Homo sapiens_hsa045200.92169658
40Estrogen signaling pathway_Homo sapiens_hsa049150.91782234
41Long-term potentiation_Homo sapiens_hsa047200.89803381
42MicroRNAs in cancer_Homo sapiens_hsa052060.87648484
43Thyroid cancer_Homo sapiens_hsa052160.85603416
44Neurotrophin signaling pathway_Homo sapiens_hsa047220.85258267
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85118405
46Gastric acid secretion_Homo sapiens_hsa049710.81382025
47Bladder cancer_Homo sapiens_hsa052190.79208845
48Fatty acid elongation_Homo sapiens_hsa000620.75633232
49Proteoglycans in cancer_Homo sapiens_hsa052050.71086792
50Tuberculosis_Homo sapiens_hsa051520.69936078
51p53 signaling pathway_Homo sapiens_hsa041150.69231612
52Glutamatergic synapse_Homo sapiens_hsa047240.69141068
53Rap1 signaling pathway_Homo sapiens_hsa040150.64108871
54MAPK signaling pathway_Homo sapiens_hsa040100.56993532
55Hedgehog signaling pathway_Homo sapiens_hsa043400.56856731
56Renal cell carcinoma_Homo sapiens_hsa052110.56514089
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56389041
58Salivary secretion_Homo sapiens_hsa049700.56324980
59Arginine biosynthesis_Homo sapiens_hsa002200.54671803
60cAMP signaling pathway_Homo sapiens_hsa040240.50962220
61Focal adhesion_Homo sapiens_hsa045100.50599191
62Phenylalanine metabolism_Homo sapiens_hsa003600.50452496
63Pancreatic secretion_Homo sapiens_hsa049720.50355472
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50125086
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48822070
66Amphetamine addiction_Homo sapiens_hsa050310.48243456
67Insulin signaling pathway_Homo sapiens_hsa049100.48053501
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45343725
69Fat digestion and absorption_Homo sapiens_hsa049750.45196274
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44618801
71Endocytosis_Homo sapiens_hsa041440.44592988
72Circadian entrainment_Homo sapiens_hsa047130.44568192
73Tight junction_Homo sapiens_hsa045300.44127961
74ErbB signaling pathway_Homo sapiens_hsa040120.44120833
75Malaria_Homo sapiens_hsa051440.42413676
76Glucagon signaling pathway_Homo sapiens_hsa049220.42153208
77Protein digestion and absorption_Homo sapiens_hsa049740.41879586
78Axon guidance_Homo sapiens_hsa043600.41192992
79Pathways in cancer_Homo sapiens_hsa052000.39183226
80Inositol phosphate metabolism_Homo sapiens_hsa005620.39008664
81TGF-beta signaling pathway_Homo sapiens_hsa043500.38942423
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38276629
83Hippo signaling pathway_Homo sapiens_hsa043900.38073042
84Basal cell carcinoma_Homo sapiens_hsa052170.36581333
85Olfactory transduction_Homo sapiens_hsa047400.36041294
86TNF signaling pathway_Homo sapiens_hsa046680.35931833
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35911135
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.34755512
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34707949
90Phagosome_Homo sapiens_hsa041450.34246018
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33943294
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33523846
93Calcium signaling pathway_Homo sapiens_hsa040200.31840838
94Notch signaling pathway_Homo sapiens_hsa043300.31590441
95Gap junction_Homo sapiens_hsa045400.31103053
96Dopaminergic synapse_Homo sapiens_hsa047280.30869260
97PPAR signaling pathway_Homo sapiens_hsa033200.30640266
98Hepatitis C_Homo sapiens_hsa051600.30580381
99Salmonella infection_Homo sapiens_hsa051320.30355085
100Toxoplasmosis_Homo sapiens_hsa051450.30321952

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